World wide approved drugs
Database contains information on about 3,936 medications, including the name of the drug, synonyms, the structural formula of the drug substance, pharmacotherapeutic fields and mechanisms of action.
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| Structure | Brand Name | Target | Pharmacotheraputic application | Pharmacological class | Approved link | PDB link | PASSOnline prediction |
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| Structure | Brand Name | Target | Pharmacotheraputic application | Pharmacological class | Approved link | PDB link | PASSOnline prediction |
| acalabrutinib | Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Tec (Organism: Homo sapiens, class: Kinase, accessions: P42680, gene: TEC, swissprot: TEC_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) | Acalabrutinib is a small-molecule inhibitor of BTK. Acalabrutinib and its active metabolite, ACP-5862, form a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B cell antigen receptor (BCR) and cytokine receptor pathways. In B cells, BTK signaling results in activation of pathways necessary for B-cell proliferation, trafficking, chemotaxis, an adhesion. In nonclinical studies, acalabrutinib inhibited BTK mediated activation of downstream signaling proteins CD86 and CD69 and inhibited malignant B-cell proliferation and survival. | 2017-10-31 FDA |  |
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| latanoprostene bunod | Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) agonist (Source: https://www.ncbi.nlm.nih.gov/pubmed/21396362) | Latanoprostene bunod is thought to lower intraocular pressure by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. Intraocular pressure is a major modifiable risk factor for glaucoma progression. Reduction of intraocular pressure reduces risk of glaucomatous visual field loss. | 2017-11-02 FDA | |
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| letermovir | DNA terminase complex (Organism: Human cytomegalovirus (strain Merlin), class: Enzyme, accessions: F5HC79|F5HCU8|F5HGI9, gene: TRM1|TRM2|TRM3, swissprot: TRM1_HCMVM|TRM2_HCMVM|TRM3_HCMVM) | Letermovir inhibits the CMV DNA terminase complex (pUL51, pUL56, and pUL89) which is required for viral DNA processing and packaging. Biochemical characterization and electron microscopy demonstrated that letermovir affects the production of proper unit length genomes and interferes with virion maturation. Genotypic characterization of virus resistant to letermovir confirmed that letermovir targets the terminase complex. | 2017-11-08 FDA | |
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| vaborbactam | Vaborbactam is a non-suicidal beta-lactamase inhibitor that protects meropenem from degradation by certain serine beta-lactamases such as Klebsiella pneumoniae carbapenemase (KPC). Vaborbactam does not have any antibacterial activity. Vaborbactam does not decrease the activity of meropenem against meropenem-susceptible organisms. | 2017-08-29 FDA | 4XUX 4XUZ |
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| levornidazole | Levornidazole is a nitroimidazole derivative, which is mediated through the reduction in anaerobic environment into amino or the formation of free radicals from the nitro, interacting with celluar components, results in the death of microorganisms. It is indicated for the treatment of a variety of infectious diseases caused by sensitive anaerobic bacteria. | 2009-08-13 China Food and Drug Administration (CFDA) | |
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| morinidazole | Morinidazole is a nitroimidazole antibiotic indicated for the treatment of sensitive anaerobic bacterial infections including appendicitis and pelvic inflammatory disease caused by anaerobic bacteria. | 2014-02-24 China Food and Drug Administration (CFDA) | |
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| forodesine | Purine nucleoside phosphorylase (Organism: Homo sapiens, class: Enzyme, accessions: P00491, gene: PNP, swissprot: PNPH_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17897085) | Forodesine is a transition state analogue that binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction. | 2017-03-30 PMDA | |
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| midostaurin | Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) | Midostaurin is a small molecule that inhibits multiple receptor tyrosine kinases. In vitro biochemical or cellular assays have shown that midostaurin or its major human active metabolites CGP62221 and CGP52421 inhibit the activity of wild type FLT3, FLT3 mutant kinases (ITD and TKD), KIT (wild type and D816V mutant), PDGFR-alfa/beta, VEGFR2, as well as members of the serine/threonine kinase PKC (protein kinase C) family. Midostaurin demonstrated the ability to inhibit FLT3 receptor signaling and cell proliferation, and it induced apoptosis in leukemic cells expressing ITD and TKD mutant FLT3 receptors or overexpressing wild type FLT3 and PDGF receptors. Midostaurin also demonstrated the ability to inhibit KIT signaling, cell proliferation and histamine release and induce apoptosis in mast cells. | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Kinase Inhibitor (Code: N0000175605) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Protein Kinase Inhibitors (Code: D047428) | 2017-04-28 FDA | 4NCT |
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| macimorelin | Growth hormone secretagogue receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: Q92847, gene: GHSR, swissprot: GHSR_HUMAN) | Macimorelin stimulates GH release by activating growth hormone secretagogue receptors present in the pituitary and hypothalamus. | 2017-12-20 FDA | |
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| baricitinib | Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) inhibitor (Source: Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) inhibitor (Source: | Baricitinib is a selective and reversible inhibitor of Janus kinase (JAK)1 and JAK2. Janus kinases (JAKs) are enzymes that transduce intracellular signals from cell surface receptors for a number of cytokines and growth factors involved in haematopoiesis, inflammation and immune function. Within the intracellular signalling pathway, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), which activate gene expression within the cell. Baricitinib modulates these signalling pathways by partially inhibiting JAK1 and JAK2 enzymatic activity, thereby reducing the phosphorylation and activation of STATs. | 2017-02-13 EMA | 4W9X |
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| rucaparib | Poly [ADP-ribose] polymerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P09874, gene: PARP1, swissprot: PARP1_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209115s000lbl.pdf) Poly [ADP-ribose] polymerase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UGN5, gene: PARP2, swissprot: PARP2_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209115s000lbl.pdf) Poly [ADP-ribose] polymerase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6F1, gene: PARP3, swissprot: PARP3_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209115s000lbl.pdf Poly [ADP-ribose] polymerase 4 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKK3, gene: PARP4, swissprot: PARP4_HUMAN) inhibitor (Source: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00990) Tankyrase-1 (Organism: Homo sapiens, class: Enzyme, accessions: O95271, gene: TNKS, swissprot: TNKS1_HUMAN) inhibitor (Source: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00990) Tankyrase-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9H2K2, gene: TNKS2, swissprot: TNKS2_HUMAN) inhibitor (Source: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00990) Poly [ADP-ribose] polymerase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q53GL7, gene: PARP10, swissprot: PAR10_HUMAN) inhibitor (Source: Poly [ADP-ribose] polymerase 12 (Organism: Homo sapiens, class: Enzyme, accessions: Q9H0J9, gene: PARP12, swissprot: PAR12_HUMAN) inhibitor (Source: Poly [ADP-ribose] polymerase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q460N5, gene: PARP14, swissprot: PAR14_HUMAN) inhibitor (Source: Poly [ADP-ribose] polymerase 15 (Organism: Homo sapiens, class: Enzyme, accessions: Q460N3, gene: PARP15, swissprot: PAR15_HUMAN) inhibitor (Source: | Rucaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP-1, PARP-2, and PARP-3, which play a role in DNA repair. In vitro studies have shown that rucaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death. Increased rucaparib-induced cytotoxicity was observed in tumor cell lines with deficiencies in BRCA1/2 and other DNA repair genes. Rucaparib has been shown to decrease tumor growth in mouse xenograft models of human cancer with or without deficiencies in BRCA. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Poly(ADP-Ribose) Polymerase Inhibitor (Code: N0000191623) Poly(ADP-ribose) Polymerase Inhibitors (Code: D000067856) | 2016-12-19 FDA | 4BJC 4RV6 |
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| icotinib | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) | Icotinib is a new epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that developed and used in China for the treatment of patients with non-small cell lung cancer (NSCLC). | 2011 China Food and Drug Administration (CFDA) | |
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| olmutinib | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) | Olmutinib is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) for the treatment of non-small cell lung cancer (NSCLC). Third-generation EGFR TKIs with covalent binding to the receptors demonstrate irreversible enzymatic inhibition of activating EGFR mutations and T790M mutation (a common reason for acquired EGFR TKI resistance), while sparing wild-type EGFR. | 2016-05 Korean Food and Drug Administration (KFDA) | |
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| crisaborole | Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Organism: Homo sapiens, class: Enzyme, accessions: P54750, gene: PDE1A, swissprot: PDE1A_HUMAN) High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Organism: Homo sapiens, class: Enzyme, accessions: Q13946, gene: PDE7A, swissprot: PDE7A_HUMAN) | Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor. PDE-4 inhibition results in increased intracellular cyclic adenosine monophosphate (cAMP) levels. The specific mechanism(s) by which crisaborole exerts its therapeutic action for the treatment of atopic dermatitis is not well defined. | antipsoriatic (Code: CHEBI:50748) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Phosphodiesterase 4 Inhibitor (Code: N0000182961) Phosphodiesterase 4 Inhibitors (Code: N0000182960) | 2016-12-14 FDA | |
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| radotinib | Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/25676420) | A second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. | 2012-01-05 Korean Food and Drug Administration (KFDA) | |
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| lifitegrast | Integrin alpha-L/beta-2 (Organism: Homo sapiens, class: Adhesion, accessions: P05107|P20701, gene: ITGAL|ITGB2, swissprot: ITAL_HUMAN|ITB2_HUMAN) antagonist (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208073s000lbl.pdf) Intercellular adhesion molecule 1 (Organism: Homo sapiens, class: Unclassified, accessions: P05362, gene: ICAM1, swissprot: ICAM1_HUMAN) None (Source: CHEMBL) | a lymphocyte function-associated antigen-1 ( LFA-1) antagonist, blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1), LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T-cell activation and migration to target tissues | anti-inflammatory drug (Code: CHEBI:35472) Lymphocyte Function-Associated Antigen-1 Antagonist (Code: N0000192701) Lymphocyte Function-Associated Antigen-1 Antagonists (Code: N0000192700) Ophthalmic Solutions (Code: D009883) Pharmaceutical Solutions (Code: D019999) | 2016-07-11 FDA | |
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| pemafibrate | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) agonist (Source: https://www.ncbi.nlm.nih.gov/pubmed/17553678) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) agonist (Source: https://www.ncbi.nlm.nih.gov/pubmed/17553678) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) agonist (Source: https://www.ncbi.nlm.nih.gov/pubmed/17553678) | Pemafibrate is a selective PPAR-alpha modulator (SPPARM-alpha) that has antihyperlipidaemic activity. | 2017-07-03 PMDA | |
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| zabofloxacin | Zabofloxacin is a fluoroquinolone antibiotic with enhanced in-vitro activity against Streptococcus pneumoniae, including strains resistant to other antibiotics. The spectrum of activity of Zabofloxacin includes those bacterial strains that are responsible for most community-acquired respiratory infections. | 2015-03-20 Korean Food and Drug Administration (KFDA) | |
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| imrecoxib | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/15210067) | Imrecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor indicated for treatment of osteoarthritis. | 2011-05-20 China Food and Drug Administration (CFDA) | |
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| enasidenib | Isocitrate dehydrogenase [NADP], mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P48735, gene: IDH2, swissprot: IDHP_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf) | Enasidenib is a small molecule inhibitor of the isocitrate dehydrogenase 2 (IDH2) enzyme. Enasidenib targets the mutant IDH2 variants R140Q, R172S, and R172K at approximately 40-fold lower concentrations than the wild-type enzyme in vitro. Inhibition of the mutant IDH2 enzyme by enasidenib led to decreased 2-hydroxyglutarate (2-HG) levels and induced myeloid differentiation in vitro and in vivo in mouse xenograft models of IDH2 mutated AML. In blood samples from patients with AML with mutated IDH2, enasidenib decreased 2-HG levels, reduced blast counts and increased percentages of mature myeloid cells. | 2017-08-01 FDA | 5I96 |
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| fluciclovine (18F) | a radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with diagnostic imaging use | Radioactive Diagnostic Agent (Code: N0000177914) Positron Emitting Activity (Code: N0000175869) | 2016-05-27 FDA | |
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| hydrocortisone phosphate | None | 1960-08-06 FDA | |
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| meglumine | 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1974-04-30 FDA | |
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| cefathiamidine | first generation of cephalosporin antibacterial used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis | 2012-12-11 China Food and Drug Administration (CFDA) | |
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| eldecalcitol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) agonist (Source: KEGG) Vitamin D3 receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P13053, gene: Vdr, swissprot: VDR_RAT) agonist (Source: IUPHAR) | an analog of vitamin D for the treatment of osteoporosis | Bone Density Conservation Agents (Code: D050071) | 2011-01-21 PMDA | 3WGP |
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| pentapiperium metilsulfate | None | |
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| pimavanserin | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) inverse agonist (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/207318lbl.pdf) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) inverse agonist (Source: https://www.ncbi.nlm.nih.gov/pubmed/16469866) | an atypical antipsychotic, mechanism of action of pimavanserin in the treatment of hallucinations and delusions associated with Parkinson's disease psychosis is unknown. However, the effect of pimavanserin could be mediated through a combination of inverse agonist and antagonist activity at serotonin 5-HT2A receptors and to a lesser extent at serotonin 5-HT2C receptors | antipsychotic agent (Code: CHEBI:35476) serotonergic antagonist (Code: CHEBI:48279) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Atypical Antipsychotic (Code: N0000175430) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin 5-HT2 Receptor Agonists (Code: D058826) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Tranquilizing Agents (Code: D014149) | 2016-04-29 FDA | |
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| opicapone | Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/24847974) Catechol O-methyltransferase (Organism: Mus musculus, class: Enzyme, accessions: O88587, gene: Comt, swissprot: COMT_MOUSE) inhibitor (Source: IUPHAR) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) inhibitor (Source: IUPHAR) | a peripheral, selective and reversible catechol-O-methyltransferase (COMT) inhibitor endowed with a high binding affinity (sub-picomolar) that translates into a slow complex dissociation rate constant and a long duration of action (>24 hours) in vivo | Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Catechol O-Methyltransferase Inhibitors (Code: D065098) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) | 2016-06-24 EMA | |
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| neratinib | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208051s000lbl.pdf) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208051s000lbl.pdf) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208051s000lbl.pdf) | Neratinib is a kinase inhibitor that irreversibly binds to Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and HER4. In vitro, neratinib reduces EGFR and HER2 autophosphorylation, downstream MAPK and AKT signaling pathways, and showed antitumor activity in EGFR and/or HER2 expressing carcinoma cell lines. Neratinib human metabolites M3, M6, M7 and M11 inhibited the activity of EGFR, HER2 and HER4 in vitro. In vivo, oral administration of neratinib inhibited tumor growth in mouse xenograft models with tumor cell lines expressing HER2 and EGFR. | antineoplastic agent (Code: CHEBI:35610) | 2017-07-17 FDA | |
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| venetoclax | Apoptosis regulator Bcl-2 (Organism: Homo sapiens, class: Cytosolic other, accessions: P10415, gene: BCL2, swissprot: BCL2_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208573s000lbl.pdf) Bcl-2-like protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q07817, gene: BCL2L1, swissprot: B2CL1_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/23291630) Apoptosis regulator Bcl-W (Organism: Homo sapiens, class: Cytosolic other, accessions: Q92843, gene: BCL2L2, swissprot: B2CL2_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/23291630) | Venetoclax is a selective and orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. Overexpression of BCL-2 has been demonstrated in CLL cells where it mediates tumor cell survival and has been associated with resistance to chemotherapeutics. Venetoclax helps restore the process of apoptosis by binding directly to the BCL-2 protein, displacing pro-apoptotic proteins like BIM, triggering mitochondrial outer membrane permeabilization and the activation of caspases. In nonclinical studies, venetoclax has demonstrated cytotoxic activity in tumor cells that overexpress BCL-2. | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) BCL-2 Inhibitor (Code: N0000192515) Increased Cellular Death (Code: N0000009176) P-Glycoprotein Inhibitors (Code: N0000185503) | 2016-04-11 FDA | |
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| brivaracetam | Synaptic vesicle glycoprotein 2A (Organism: Homo sapiens, class: Transporter, accessions: Q7L0J3, gene: SV2A, swissprot: SV2A_HUMAN) modulator (Source: https://www.ncbi.nlm.nih.gov/pubmed/18500360) | Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect. | anticonvulsant (Code: CHEBI:35623) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Epoxide Hydrolase Inhibitors (Code: N0000192345) | 2016-01-14 EMA | |
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| bictegravir | Bictegravir inhibits the strand transfer activity of HIV-1 integrase (integrase strand transfer inhibitor; INSTI), an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of linear HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the virus. | 2018-02-07 FDA | |
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| tezacaftor | Cystic fibrosis transmembrane conductance regulator (Organism: Homo sapiens, class: Ion channel, accessions: P13569, gene: CFTR, swissprot: CFTR_HUMAN) pharmacological chaperone (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210491lbl.pdf) | Tezacaftor facilitates the cellular processing and trafficking of normal and select mutant forms of CFTR (including F508del-CFTR) to increase the amount of mature CFTR protein delivered to the cell surface. | 2018-02-12 FDA | |
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| etelcalcetide | Extracellular calcium-sensing receptor (Organism: Homo sapiens, class: GPCR, accessions: P41180, gene: CASR, swissprot: CASR_HUMAN) agonist (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003995/WC500217100.pdf) | Etelcalcetide is a synthetic peptide calcimimetic agent which reduces parathyroid hormone (PTH) secretion through binding and activation of the calcium-sensing receptor. The reduction in PTH is associated with a concomitant decrease in serum calcium and phosphate levels. | Calcium-sensing Receptor Agonist (Code: N0000175902) Increased Calcium-sensing Receptor Sensitivity (Code: N0000020081) | 2016-11-11 EMA | |
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| mepiprazole | psychotropic agent; tranquilizer in schizophrenia; possible chronobiotic agent for therapy in circadian rhythm desynchronization; RN given refers to parent cpd; RN for EMD 16923 with MF unknown: 52499-69-1 | |
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| lorpiprazole | None | |
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| elobixibat | Ileal sodium/bile acid cotransporter (Organism: Homo sapiens, class: Transporter, accessions: Q12908, gene: SLC10A2, swissprot: NTCP2_HUMAN) inhibitor (Source: https://www.sciencedirect.com/science/article/pii/S0016508510610177?via%3Dihub) | Elobixibat is an IBAT inhibitor approved in Japan for the treatment of chronic constipation. IBAT is the bile acid/sodium symporter responsible for the reuptake of bile acids in the ileum which is the initial step in the enterohepatic circulation. By inhibiting the uptake of bile acids, elobixibat increases the bile acid concentration in the gut, and this accelerates intestinal passage and softens the stool. | 2018-01-19 PMDA | |
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| apalutamide | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210951s000lbl.pdf) | Apalutamide is an Androgen Receptor (AR) inhibitor that binds directly to the ligand-binding domain of the AR. Apalutamide inhibits AR nuclear translocation, inhibits DNA binding, and impedes AR-mediated transcription. A major metabolite, N-desmethyl apalutamide, is a less potent inhibitor of AR, and exhibited one-third the activity of apalutamide in an in vitro transcriptional reporter assay. Apalutamide administration caused decreased tumor cell proliferation and increased apoptosis leading to decreased tumor volume in mouse xenograft models of prostate cancer. | 2018-02-14 FDA | |
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| velpatasvir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 2a (isolate JFH-1), class: Polyprotein, accessions: Q99IB8, gene: None, swissprot: POLG_HCVJF) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 4a (isolate ED43), class: Polyprotein, accessions: O39929, gene: None, swissprot: POLG_HCVED) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 3a (isolate k3a) (HCV), class: Polyprotein, accessions: Q81495, gene: None, swissprot: POLG_HCVK3) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV), class: Polyprotein, accessions: Q9DHD6, gene: None, swissprot: POLG_HCVJP) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 5a (isolate SA13) (HCV), class: Polyprotein, accessions: O91936, gene: None, swissprot: POLG_HCVSA) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 6a (isolate 6a33) (HCV), class: Polyprotein, accessions: Q5I2N3, gene: None, swissprot: POLG_HCV6A) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) | pan-genotypic NS5A inhibitor for the treatment of chronic genotype 1-6 hepatitis C virus (HCV) infection | antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Organic Anion Transporting Polypeptide 2B1 Inhibitors (Code: N0000190109) | 2016-06-28 FDA | |
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| monoxerutin | None | |
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| oxiglutatione | A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized. | 2008-07-24 FDA | 1YKC 2GRT 2WDU 3FR3 3GX0 3M8U 4C0R 4F0B 4F0C 4IS0 4MRS 4MZW 4NAX 4TR0 4ZB6 4ZB8 4ZB9 4ZBA 5O00 5THY |
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| elbasvir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 4a (isolate ED43), class: Polyprotein, accessions: O39929, gene: None, swissprot: POLG_HCVED) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) | inhibits NS5A protein of hepatitis C virus | antiviral drug (Code: CHEBI:36044) hepatoprotective agent (Code: CHEBI:62868) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) | 2016-01-28 FDA | |
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| etimicin | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 2014-09-15 China Food and Drug Administration (CFDA) | |
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| obeticholic acid | Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) agonist (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/207999s000lbl.pdf) G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) None (Source: CHEMBL) | obeticholic acid is an agonist for FXR, a nuclear receptor expressed in the liver and intestine | hepatoprotective agent (Code: CHEBI:62868) Farnesoid X Receptor Agonist (Code: N0000192561) Farnesoid X Receptor Agonists (Code: N0000192560) | 2016-05-27 FDA | 1OSV 1OT7 |
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| grazoprevir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 4a (isolate ED43), class: Polyprotein, accessions: O39929, gene: None, swissprot: POLG_HCVED) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) | has antiviral activity | antiviral drug (Code: CHEBI:36044) hepatoprotective agent (Code: CHEBI:62868) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 2016-01-28 FDA | 3SUD 3SUE 3SUF 3SUG |
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| climbazole | Climbazole is a conazole fungicide. It is also use in shampoo and cleaner as an anti-dandruff agents and anti-bacteria agent. | |
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| trenbolone hexahydrobenzylcarbonate | Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) None (Source: CHEMBL) | None | |
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| ixazomib | Proteasome subunit beta type-5 (Organism: Homo sapiens, class: Enzyme, accessions: P28074, gene: PSMB5, swissprot: PSB5_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/208462lbl.pdf) Proteasome subunit beta type-2 (Organism: Homo sapiens, class: Enzyme, accessions: P49721, gene: PSMB2, swissprot: PSB2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20160034) Proteasome subunit beta type-1 (Organism: Homo sapiens, class: Enzyme, accessions: P20618, gene: PSMB1, swissprot: PSB1_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/20160034) | an oral proteasome inhibitor with antineoplastic activity; MLN2238 is the biologically active form of MLN9708 | orphan drug (Code: CHEBI:71031) proteasome inhibitor (Code: CHEBI:52726) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Proteasome Inhibitors (Code: N0000175075) Protease Inhibitors (Code: D011480) | 2015-11-20 FDA | 5LF7 |
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| alfadolone acetate | a neuroactive steroid and general anesthetic | |
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| cobimetinib | Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) inhibitor (Source: https://www.ncbi.nlm.nih.gov/pubmed/22084396) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) negative allosteric modulator (Source: IUPHAR) | Cobimetinib is a reversible inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase 1 (MEK1) and MEK2. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. BRAF V600E and K mutations result in constitutive activation of the BRAF pathway which includes MEK1 and MEK2. In mice implanted with tumor cell lines expressing BRAF V600E, cobimetinib inhibited tumor cell growth. | antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) | 2015-11-10 FDA 2015-11-10 EMA | 4AN2 4LMN |
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| saroglitazar | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/26171220) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/26171220) | a PPARalpha and PPARgamma agonist | hypoglycemic agent (Code: CHEBI:35526) | 2013-02-25 CDSCO (INDIA) | |
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| pitolisant | Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) inverse agonist (Source: https://www.ncbi.nlm.nih.gov/pubmed/21615387) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) None (Source: CHEMBL) Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) None (Source: CHEMBL) | Pitolisant is a potent, orally active histamine H3-receptor antagonist/inverse agonist which, via its blockade of histamine auto-receptors enhances the activity of brain histaminergic neurons, a major arousal system with widespread projections to the whole brain. Pitolisant also modulates various neurotransmitter systems, increasing acetylcholine, noradrenaline and dopamine release in the brain. | 2016-03-31 EMA | |
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| flibanserin | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/12177684) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/12177684) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/12177684) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20840530) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20840530) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20840530) | a serotonin receptor modulator with high affinity for the following serotonin (5-hydroxytryptamine or 5-T) receptors: agonist activity at 5-HT1A and antagonist activity at 5-HT2A. Flibanserin also has moderate antagonist activities at the 5-HT2B, 5-HT2C, and dopamine D4 receptors, used in the treatment of premenopausal women with hypoactive sexual desire disorder | serotonergic agonist (Code: CHEBI:35941) serotonergic antagonist (Code: CHEBI:48279) antidepressant (Code: CHEBI:35469) P-Glycoprotein Inhibitors (Code: N0000185503) | 2015-08-18 FDA | |
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| trelagliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26115728) | Trelagliptin is an orally active dipeptidyl peptidase (DPP)-4 inhibitor developed by Takeda and approved in Japan for the treatment of type 2 diabetes mellitus. | 2015-03-26 PMDA | 5KBY |
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| gluconolactone | Glucosylceramidase (Organism: Homo sapiens, class: Enzyme, accessions: P04062, gene: GBA, swissprot: GLCM_HUMAN) None (Source: CHEMBL) | None | Calculi Dissolution Agent (Code: N0000175835) Irrigation (Code: N0000175534) | 1990-10-02 FDA | 1E6X 2E40 2VWG 2W39 3AZZ 3EQO 3VIF 4YNU 4ZLG 4ZOB 5XXM |
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| angiotensin II | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) agonist (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209360s000lbl.pdf) Type-2 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P50052, gene: AGTR2, swissprot: AGTR2_HUMAN) agonist (Source: IUPHAR) | Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure. Angiotensin II raises blood pressure by vasoconstriction and increased aldosterone release. Direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells, which stimulates Ca2+/calmodulin-dependent phosphorylation of myosin and causes smooth muscle contraction. | Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662) | 2017-12-21 FDA | |
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| faropenem medoxil | Faropenem medoxomil is a prodrug of Faropenem sodium, the first oral penem-type antibiotic launched in 1997 in Japan. It is orally active and well absorbed through the gastro-intestinal tract, and rapidly converted to Faropenem. It is effective against various pathogenic bacteria, including the problematic antibiotic-resistant bacteria, PRSP (penicillin-resistant Streptococcus pneumoniae ) | |
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| UREA C 14 | Urea 14C is a urea molecule radiolabelled with a radioactive carbon-14. It is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed as PyTest) for the detection of Helicobacter pylori infections. | 1997-05-09 FDA | |
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| copanlisib | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209936s000lbl.pdf) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209936s000lbl.pdf) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Organism: Homo sapiens, class: Kinase, accessions: P42338, gene: PIK3CB, swissprot: PK3CB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24170767) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Organism: Homo sapiens, class: Kinase, accessions: P48736, gene: PIK3CG, swissprot: PK3CG_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24170767) | Copanlisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3K-alpha and PI3K-delta isoforms expressed in malignant B cells. Copanlisib has been shown to induce tumor cell death by apoptosis and inhibition of proliferation of primary malignant B cell lines. Copanlisib inhibits several key cell-signaling pathways, including B-cell receptor (BCR) signaling, CXCR12 mediated chemotaxis of malignant B cells, and NFkB signaling in lymphoma cell lines. | 2017-09-14 FDA | 5G2N |
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| sacubitril | Neprilysin (Organism: Homo sapiens, class: Enzyme, accessions: P08473, gene: MME, swissprot: NEP_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207620Orig1s000lbl.pdf) | inhibits neprilysin (neutral endopeptidase; NEP) via LBQ657, the active metabolite of the prodrug sacubitril and leads to increased levels of peptides that are degraded by neprilysin such as natriuretic peptides | 2015-07-07 FDA | |
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| rolapitant | Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) antagonist (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206500s000lbl.pdf) | An orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life. | antiemetic (Code: CHEBI:50919) Neurokinin 1 Antagonists (Code: N0000010262) Substance P/Neurokinin-1 Receptor Antagonist (Code: N0000175786) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) P-Glycoprotein Inhibitors (Code: N0000185503) | 2015-09-01 FDA | |
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| uridine triacetate | Uridine triacetate is an acetylated form of uridine. Following oral administration, uridine triacetate is deacetylated by nonspecific esterases present throughout the body, yielding uridine in the systemic circulation of patients with hereditary orotic aciduria who cannot synthesize adequate quantities of uridine due to a genetic defect in uridine nucleotide synthesis. | prodrug (Code: CHEBI:50266) neuroprotective agent (Code: CHEBI:63726) orphan drug (Code: CHEBI:71031) Pyrimidine Analog (Code: N0000191809) Pyrimidines (Code: N0000007587) Analogs/Derivatives (Code: N0000175452) | 2015-09-04 FDA | |
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| olanexidine | Olanexidine is a monobiguanide compound with bactericidal activity. | 2015-07-03 PMDA | |
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| tivozanib | Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004131/WC500239033.pdf) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004131/WC500239033.pdf) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004131/WC500239033.pdf) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) | Tivozanib is an oral, once-daily, vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI). It is a potent, selective and long half-life inhibitor of all three VEGF receptors and is designed to optimize VEGF blockade while minimizing off-target toxicities, potentially resulting in improved efficacy and minimal dose modifications. Tivozanib is indicated as first line treatment of adult patients with advanced renal cell carcinoma (RCC) and for adult patients who are VEGFR and mTOR pathway inhibitor-naive following disease progression after one prior treatment with cytokine therapy for advanced RCC. | 2017-08-24 EMA | |
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| menadiol sodium diphosphate | None | 1941 FDA | |
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| brexpiprazole | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205422s000lbl.pdf) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205422s000lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205422s000lbl.pdf) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) | an atypical antipsychotic the efficacy of brexpiprazole may be mediated through a combination of partial agonist activity at serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Atypical Antipsychotic (Code: N0000175430) Serotonin Agents (Code: D018490) | 2015-07-10 FDA | |
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| eluxadoline | Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206940s000lbl.pdf) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206940s000lbl.pdf) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22671931) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206940s000lbl.pdf) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) None (Source: CHEMBL) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) None (Source: CHEMBL) | Eluxadoline is a mu-opioid receptor agonist; eluxadoline is also a delta opioid receptor antagonist and a kappa opioid receptor agonist. The binding affinities (Ki) of eluxadoline for the human mu and delta opioid receptors are 1.8 nM and 430 nM, respectively. The binding affinity (Ki) of eluxadoline for the human kappa opioid receptor has not been determined; however, the Ki for guinea pig cerebellum kappa opioid receptor is 55 nM. In animals, eluxadoline interacts with opioid receptors in the gut. | mu-opioid receptor agonist (Code: CHEBI:55322) delta-opioid receptor antagonist (Code: CHEBI:59283) kappa-opioid receptor agonist (Code: CHEBI:59282) gastrointestinal drug (Code: CHEBI:55324) Gastrointestinal Agents (Code: D005765) Opioid mu-Receptor Agonists (Code: N0000191866) | 2015-05-27 FDA | |
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| deoxycholic acid | Cell membrane (Organism: None, class: Cell membrane, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206333Orig1s000lbl.pdf) Steroid Delta-isomerase (Organism: Pseudomonas putida, class: Unclassified, accessions: P07445, gene: ksi, swissprot: SDIS_PSEPU) None (Source: CHEMBL) fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) antagonist (Source: IUPHAR) G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) agonist (Source: IUPHAR) | A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent. | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) Cytolytic Agent (Code: N0000191548) Decreased Cell Membrane Integrity (Code: N0000008476) | 2015-04-29 FDA | 1E3V 1FM4 1OS6 2BJF 2OPX 2W1B 3DTU 3O01 3R9V 3RV5 3SEL 3SJ0 3SJ1 3SJ4 3ZQE 4A81 4A83 4A84 4AC9 4ACA 4ACB 4HAJ 4HB6 4HB8 4HBF 4HC3 4HDL 4QN9 4ZP0 |
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| triamcinolone hexacetonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/016466s046lbl.pdf) | synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems | Anti-Inflammatory Agents (Code: D000893) | 1969-07-29 FDA | |
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| ombitasvir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206619s003lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206619s003lbl.pdf) | inhibits HCV NS5A protein | antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) UGT1A1 Inhibitors (Code: N0000191272) | 2014-11-20 EMA | |
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| isavuconazonium | Aspergillus fumigatus (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207500Orig1s000lbl.pdf) Candida albicans (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207500Orig1s000lbl.pdf) | Isavuconazonium sulfate is the prodrug of isavuconazole, an azole antifungal drug. Isavuconazole inhibits the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14-alpha-demethylase. This enzyme is responsible for the conversion of lanosterol to ergosterol. An accumulation of methylated sterol precursors and a depletion of ergosterol within the fungal cell membrane weakens the membrane structure and function. Mammalian cell demethylation is less sensitive to isavuconazole inhibition. | prodrug (Code: CHEBI:50266) orphan drug (Code: CHEBI:71031) Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) P-Glycoprotein Inhibitors (Code: N0000185503) | 2015-03-06 FDA | |
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| isoflupredone acetate | None | |
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| drofenine | None | |
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| arformoterol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/12090787) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021912s013lbl.pdf) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) None (Source: CHEMBL) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) None (Source: CHEMBL) | the (R,R)-enantiomer of formoterol, is a selective long-acting beta2-adrenergic receptor agonist (beta2-agonist) that has two-fold greater potency than racemic formoterol | bronchodilator agent (Code: CHEBI:35523) anti-asthmatic drug (Code: CHEBI:49167) beta-adrenergic agonist (Code: CHEBI:35522) Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) | 2006-10-06 FDA | |
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| tenofovir alafenamide | a phosphonoamidate prodrug of tenofovir (2'deoxyadenosine monophosphate analog). Plasma exposure to tenofovir alafenamide allows for permeation into cells and then tenofovir alafenamide is intracellularly converted to tenofovir through hydrolysis by cathepsin A. Tenofovir is subsequently phosphorylated by cellular kinases to the active metabolite tenofovir diphosphate. Tenofovir diphosphate inhibits HIV replication through incorporation into viral DNA by the HIV reverse transcriptase, which results in DNA chain-termination | antiviral drug (Code: CHEBI:36044) prodrug (Code: CHEBI:50266) | 2015-05-11 FDA | |
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| avibactam | Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: P05364, gene: ampC, swissprot: AMPC_ENTCL) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23913691) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q9EXV5, gene: blaUOE-1, swissprot: Q9EXV5_ECOLX) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23913691) Beta-lactamase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: P24735, gene: ampC, swissprot: AMPC_PSEAE) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23913691) | a non-beta-lactam beta-lactamase inhibitor that inactivates some beta-lactamases and protects ceftazidime from degradation by certain beta-lactamases | antibacterial drug (Code: CHEBI:36047) beta Lactamase Inhibitor (Code: N0000175930) beta Lactamase Inhibitors (Code: N0000000202) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) beta-Lactamase Inhibitors (Code: D065093) Enzyme Inhibitors (Code: D004791) | 2015-02-25 FDA | |
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| daclatasvir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20410884) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20410884) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: CHEMBL) | an HCV NS5A inhibitor | antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) | 2014-09-15 EMA | |
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| palbociclib | Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207103s000lbl.pdf) Cyclin-dependent kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q00534, gene: CDK6, swissprot: CDK6_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207103s000lbl.pdf) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/15542782) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/15542782) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: CHEMBL) CDK2/Cyclin A (Organism: Homo sapiens, class: Kinase, accessions: P20248|P24941, gene: CCNA2|CDK2, swissprot: CCNA2_HUMAN|CDK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P50750, gene: CDK9, swissprot: CDK9_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 4/cyclin D1 (Organism: Homo sapiens, class: Kinase, accessions: P11802|P24385, gene: CCND1|CDK4, swissprot: CCND1_HUMAN|CDK4_HUMAN) None (Source: CHEMBL) CDK6/cyclin D1 (Organism: Homo sapiens, class: Kinase, accessions: P24385|Q00534, gene: CCND1|CDK6, swissprot: CCND1_HUMAN|CDK6_HUMAN) None (Source: CHEMBL) | Palbociclib is an inhibitor of cyclin-dependent kinases (CDK) 4 and 6. Cyclin D1 and CDK4/6 are downstream of signaling pathways which lead to cellular proliferation. In vitro, palbociclib reduced cellular proliferation of estrogen receptor (ER)-positive breast cancer cell lines by blocking progression of the cell from G1 into S phase of the cell cycle. Treatment of breast cancer cell lines with the combination of palbociclib and antiestrogens leads to decreased retinoblastoma (Rb) protein phosphorylation resulting in reduced E2F expression and signaling, and increased growth arrest compared to treatment with each drug alone. In vitro treatment of ER-positive breast cancer cell lines with the combination of palbociclib and antiestrogens led to increased cell senescence compared to each drug alone, which was sustained for up to 6 days following palbociclib removal and was greater if antiestrogen treatment was continued. In vivo studies using a patient-derived ER-positive breast cancer xenograft model demonstrated that the combination of palbociclib and letrozole increased the inhibition of Rb phosphorylation, downstream signaling, and tumor growth compared to each drug alone. | antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) Cytochrome P450 3A Inhibitors (Code: N0000190114) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) | 2015-02-03 FDA | 2EUF 5L2I |
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| lenvatinib | Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17943726) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17943726) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) | a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet derived growth factor receptor alpha (PDGFR?), KIT, and RET. | orphan drug (Code: CHEBI:71031) antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) | 2015-02-13 FDA | 3WZD 5ZV2 |
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| decamethoxine | a bisquaternary ammonium salt | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | None Ministry of Health of the Russian Federation | |
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| finafloxacin | Pseudomonas aeruginosa (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/21709094) Staphylococcus aureus subsp. aureus (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/21709094) | Finafloxacin belongs to the fluoroquinolone class of antibacterials which involves the inhibition of bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination. | antibacterial drug (Code: CHEBI:36047) Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) | 2014-12-17 FDA | |
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| safinamide | Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17915852) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: CHEMBL) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) None (Source: CHEMBL) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: CHEMBL) | Safinamide acts through both dopaminergic and non-dopaminergic mechanisms of action. Safinamide is a highly selective and reversible MAO-B inhibitor causing an increase in extracellular levels of dopamine in the striatum. Safinamide is associated with state-dependent inhibition of voltage-gated sodium (Na+) channels, and modulation of stimulated release of glutamate. To what extent the nondopaminergic effects contribute to the overall effect has not been established. | Monoamine Oxidase Type B Inhibitor (Code: N0000175762) Monoamine Oxidase-B Inhibitors (Code: N0000175761) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) | 2014-03-30 EMA | |
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| ceftolozane | Ceftolozane belongs to the cephalosporin class of antibacterial drugs. The bactericidal action of ceftolozane results from inhibition of cell wall biosynthesis, and is mediated through binding to penicillin-binding proteins (PBPs). Ceftolozane is an inhibitor of PBPs of P. aeruginosa (e.g., PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3). | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) | 2014-12-19 FDA | |
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| acotiamide | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21651906) | A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. | 2013-03-25 PMDA | |
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| felypressin | Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/18655903) | A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity. | vasoconstrictor agent (Code: CHEBI:50514) vasopressin receptor agonist (Code: CHEBI:59727) Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662) | 1969-12-31 New Zealand Medicines and Medical Devices Safety Authority | |
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| netupitant | Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/16332435) | a selective antagonist of human substance P/neurokinin 1 (NK1) receptors, inhibits substance P mediated emesis responses | antiemetic (Code: CHEBI:50919) Neurokinin 1 Antagonists (Code: N0000010262) Substance P/Neurokinin-1 Receptor Antagonist (Code: N0000175786) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) | 2014-10-10 FDA | |
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| ledipasvir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24320933) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24320933) | an inhibitor of the HCV NS5A protein, which is required for viral replication | antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) P-Glycoprotein Inhibitors (Code: N0000185503) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 2014-10-10 FDA | |
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| diquafosol | P2Y purinoceptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P41231, gene: P2RY2, swissprot: P2RY2_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/18232657) P2Y purinoceptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P51582, gene: P2RY4, swissprot: P2RY4_HUMAN) agonist (Source: IUPHAR) | purinoceptor P2Y(2) receptor agonist | 2010-02-26 PMDA | |
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| belinostat | Histone deacetylase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P56524, gene: HDAC4, swissprot: HDAC4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/12939461) Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q96DB2, gene: HDAC11, swissprot: HDA11_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKV0, gene: HDAC9, swissprot: HDAC9_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 5 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UQL6, gene: HDAC5, swissprot: HDAC5_HUMAN) inhibitor (Source: CHEMBL) Histone deacetylase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q8WUI4, gene: HDAC7, swissprot: HDAC7_HUMAN) inhibitor (Source: CHEMBL) | a hydroxamate-type inhibitor of histone deacetylase | antineoplastic agent (Code: CHEBI:35610) Histone Deacetylase Inhibitor (Code: N0000175588) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Histone Deacetylase Inhibitors (Code: D056572) | 2014-07-03 FDA | 5EEN |
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| imidafenacin | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/10428387) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10428387) | Imidafenacin antagonizes subtypes M3 and M1 in vitro. In the urinary bladder, imidafenacin inhibits acetylcholine release by antagonizing subtype M1 and contraction of smooth muscles by antagonizing subtype M3. | 2007-04-18 PMDA | |
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| nintedanib | Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) None (Source: CHEMBL) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: CHEMBL) Protein kinase C theta type (Organism: Homo sapiens, class: Kinase, accessions: Q04759, gene: PRKCQ, swissprot: KPCT_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) None (Source: CHEMBL) Muscle, skeletal receptor tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: O15146, gene: MUSK, swissprot: MUSK_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) inhibitor (Source: CHEMBL) None (Source: CHEMBL) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase type IV (Organism: Homo sapiens, class: Kinase, accessions: Q16566, gene: CAMK4, swissprot: KCC4_HUMAN) None (Source: CHEMBL) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) inhibitor (Source: CHEMBL) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: CHEMBL) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: CHEMBL) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) None (Source: CHEMBL) Myosin-IIIb (Organism: Homo sapiens, class: Kinase, accessions: Q8WXR4, gene: MYO3B, swissprot: MYO3B_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PAK 3 (Organism: Homo sapiens, class: Kinase, accessions: O75914, gene: PAK3, swissprot: PAK3_HUMAN) None (Source: CHEMBL) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) None (Source: CHEMBL) MAP/microtubule affinity-regulating kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27448, gene: MARK3, swissprot: MARK3_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q6ZN16, gene: MAP3K15, swissprot: M3K15_HUMAN) None (Source: CHEMBL) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: CHEMBL) Casein kinase I isoform delta (Organism: Homo sapiens, class: Kinase, accessions: P48730, gene: CSNK1D, swissprot: KC1D_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) None (Source: CHEMBL) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) None (Source: CHEMBL) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) None (Source: CHEMBL) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) None (Source: CHEMBL) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: CHEMBL) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ICK (Organism: Homo sapiens, class: Kinase, accessions: Q9UPZ9, gene: ICK, swissprot: ICK_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase/endoribonuclease IRE1 (Organism: Homo sapiens, class: Kinase, accessions: O75460, gene: ERN1, swissprot: ERN1_HUMAN) None (Source: CHEMBL) MAP/microtubule affinity-regulating kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96L34, gene: MARK4, swissprot: MARK4_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase OSR1 (Organism: Homo sapiens, class: Kinase, accessions: O95747, gene: OXSR1, swissprot: OXSR1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase Sgk3 (Organism: Homo sapiens, class: Kinase, accessions: Q96BR1, gene: SGK3, swissprot: SGK3_HUMAN) None (Source: CHEMBL) STE20/SPS1-related proline-alanine-rich protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UEW8, gene: STK39, swissprot: STK39_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) None (Source: CHEMBL) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) None (Source: CHEMBL) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) None (Source: CHEMBL) Myosin light chain kinase family member 4 (Organism: Homo sapiens, class: Kinase, accessions: Q86YV6, gene: MYLK4, swissprot: MYLK4_HUMAN) None (Source: CHEMBL) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) None (Source: CHEMBL) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) None (Source: CHEMBL) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: CHEMBL) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase MARK2 (Organism: Homo sapiens, class: Kinase, accessions: Q7KZI7, gene: MARK2, swissprot: MARK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) None (Source: CHEMBL) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) None (Source: CHEMBL) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: CHEMBL) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) None (Source: CHEMBL) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: CHEMBL) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) inhibitor (Source: CHEMBL) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) inhibitor (Source: CHEMBL) Ribosomal protein S6 kinase alpha-3 (Organism: Homo sapiens, class: Kinase, accessions: P51812, gene: RPS6KA3, swissprot: KS6A3_HUMAN) None (Source: CHEMBL) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) None (Source: CHEMBL) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: Q02779, gene: MAP3K10, swissprot: M3K10_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: CHEMBL) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: CHEMBL) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) None (Source: CHEMBL) Insulin receptor-related protein (Organism: Homo sapiens, class: Kinase, accessions: P14616, gene: INSRR, swissprot: INSRR_HUMAN) None (Source: CHEMBL) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: CHEMBL) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PAK 7 (Organism: Homo sapiens, class: Kinase, accessions: Q9P286, gene: PAK5, swissprot: PAK5_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) None (Source: CHEMBL) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) None (Source: CHEMBL) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) None (Source: CHEMBL) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: CHEMBL) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: CHEMBL) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) None (Source: CHEMBL) Death-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UIK4, gene: DAPK2, swissprot: DAPK2_HUMAN) None (Source: CHEMBL) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase type 1G (Organism: Homo sapiens, class: Kinase, accessions: Q96NX5, gene: CAMK1G, swissprot: KCC1G_HUMAN) None (Source: CHEMBL) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) None (Source: CHEMBL) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) None (Source: CHEMBL) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) None (Source: CHEMBL) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: CHEMBL) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) None (Source: CHEMBL) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) None (Source: CHEMBL) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase STK11 (Organism: Homo sapiens, class: Kinase, accessions: Q15831, gene: STK11, swissprot: STK11_HUMAN) None (Source: CHEMBL) Rhodopsin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q15835, gene: GRK1, swissprot: RK_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: CHEMBL) Activin receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: Q04771, gene: ACVR1, swissprot: ACVR1_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) None (Source: CHEMBL) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: CHEMBL) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase MARK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9P0L2, gene: MARK1, swissprot: MARK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) None (Source: CHEMBL) Bone morphogenetic protein receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: Q13873, gene: BMPR2, swissprot: BMPR2_HUMAN) None (Source: CHEMBL) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase LATS2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRM7, gene: LATS2, swissprot: LATS2_HUMAN) None (Source: CHEMBL) Inhibitor of nuclear factor kappa-B kinase subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: O15111, gene: CHUK, swissprot: IKKA_HUMAN) None (Source: CHEMBL) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: CHEMBL) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) None (Source: CHEMBL) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Organism: Homo sapiens, class: Kinase, accessions: Q9Y463, gene: DYRK1B, swissprot: DYR1B_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PRP4 homolog (Organism: Homo sapiens, class: Kinase, accessions: Q13523, gene: PRPF4B, swissprot: PRP4B_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PknB (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WI81, gene: pknB, swissprot: PKNB_MYCTU) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: CHEMBL) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) None (Source: CHEMBL) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 24 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6E0, gene: STK24, swissprot: STK24_HUMAN) None (Source: CHEMBL) 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: P54646, gene: PRKAA2, swissprot: AAPK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: CHEMBL) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: CHEMBL) Uncharacterized serine/threonine-protein kinase SBK3 (Organism: Homo sapiens, class: Kinase, accessions: P0C264, gene: SBK3, swissprot: SBK3_HUMAN) None (Source: CHEMBL) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 17 (Organism: Homo sapiens, class: Kinase, accessions: Q00537, gene: CDK17, swissprot: CDK17_HUMAN) None (Source: CHEMBL) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase receptor R3 (Organism: Homo sapiens, class: Kinase, accessions: P37023, gene: ACVRL1, swissprot: ACVL1_HUMAN) None (Source: CHEMBL) Activin receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: P36896, gene: ACVR1B, swissprot: ACV1B_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: CHEMBL) TGF-beta receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: P36897, gene: TGFBR1, swissprot: TGFR1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PAK 4 (Organism: Homo sapiens, class: Kinase, accessions: O96013, gene: PAK4, swissprot: PAK4_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: O94921, gene: CDK14, swissprot: CDK14_HUMAN) None (Source: CHEMBL) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: CHEMBL) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 18 (Organism: Homo sapiens, class: Kinase, accessions: Q07002, gene: CDK18, swissprot: CDK18_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase LATS1 (Organism: Homo sapiens, class: Kinase, accessions: O95835, gene: LATS1, swissprot: LATS1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PAK 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13177, gene: PAK2, swissprot: PAK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: CHEMBL) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) None (Source: CHEMBL) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: CHEMBL) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Organism: Homo sapiens, class: Kinase, accessions: P78356, gene: PIP4K2B, swissprot: PI42B_HUMAN) None (Source: CHEMBL) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase D2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZL6, gene: PRKD2, swissprot: KPCD2_HUMAN) None (Source: CHEMBL) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: CHEMBL) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: CHEMBL) SRSF protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P78362, gene: SRPK2, swissprot: SRPK2_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) None (Source: CHEMBL) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: CHEMBL) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: CHEMBL) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) None (Source: CHEMBL) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: CHEMBL) Vascular endothelial growth factor receptor 2 (Organism: Mus musculus, class: Kinase, accessions: P35918, gene: Kdr, swissprot: VGFR2_MOUSE) None (Source: CHEMBL) Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) None (Source: CHEMBL) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) None (Source: CHEMBL) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) None (Source: CHEMBL) Glycogen synthase kinase-3 alpha (Organism: Homo sapiens, class: Kinase, accessions: P49840, gene: GSK3A, swissprot: GSK3A_HUMAN) None (Source: CHEMBL) cGMP-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13976, gene: PRKG1, swissprot: KGP1_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q13164, gene: MAPK7, swissprot: MK07_HUMAN) None (Source: CHEMBL) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: CHEMBL) | Boehringer Ingelheim's triple kinase inhibitor blocking VEGFR, PDGFR and FGFR | antineoplastic agent (Code: CHEBI:35610) angiogenesis inhibitor (Code: CHEBI:48422) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) | 2014-10-15 FDA | 3C7Q 5MAF 5TE0 |
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| cetilistat | Pancreatic triacylglycerol lipase (Organism: Homo sapiens, class: Enzyme, accessions: P16233, gene: PNLIP, swissprot: LIPP_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/18500680) | lipase inhibitor in randomized, placebo-controlled study of weight reduction in obese patients (3/2007) | Anti-Obesity Agents (Code: D019440) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Lipid Regulating Agents (Code: D057847) | 2013-09-20 PMDA | |
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| efinaconazole | Trichophyton rubrum (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/11302816) Trichophyton mentagrophytes (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/11302816) Lanosterol 14-alpha demethylase (Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892), class: Enzyme, accessions: F2SHH3, gene: None, swissprot: F2SHH3_TRIRC) inhibitor (Source: CHEMBL) | Efinaconazole is an azole antifungal. Efinaconazole inhibits fungal lanosterol 14-alpha demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 2014-06-06 FDA | |
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| favipiravir | H1N1 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) H2N2 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) H3N2 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) H1N5 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) | A pyrazinecarboxamide derivative with activity against RNA viruses. Favipiravir is converted to the ribofuranosyltriphosphate derivative by host enzymes and selectively inhibits the influenza viral RNA-dependent RNA polymerase. | 2014-02-03 PMDA | |
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| topiroxostat | Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19783139) | xanthine oxidoreductase inhibitor | Enzyme Inhibitors (Code: D004791) | 2013-04-26 PMDA | 1V97 |
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| asunaprevir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22869577) | an NS3 protease inhibitor against hepatitis C virus | Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 2014-06-24 PMDA | 4NWL 4WF8 4WH6 5EQS |
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| ipragliflozin | Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22139434) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/22139434) | inhibits sodium-dependent glucose co-transporter 2 (SGLT2) | 2014-11-29 PMDA | |
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| luseogliflozin | Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20302302) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20302302) | an antidiabetic agent that inhibits sodium-dependent glucose cotransporter 2 (SGLT2) | 2014-03-24 PMDA | |
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| suvorexant | Orexin receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: O43613, gene: HCRTR1, swissprot: OX1R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20565075) Orexin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: O43614, gene: HCRTR2, swissprot: OX2R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20565075) Orexin receptor type 1 (Organism: Mus musculus, class: GPCR, accessions: P58307, gene: Hcrtr1, swissprot: OX1R_MOUSE) None (Source: CHEMBL) Orexin receptor type 2 (Organism: Mus musculus, class: GPCR, accessions: P58308, gene: Hcrtr2, swissprot: OX2R_MOUSE) None (Source: CHEMBL) | a highly selective antagonist for orexin receptors OX1R and OX2R, the orexin neuropeptide signaling system is a central promoter of wakefulness, blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive | central nervous system depressant (Code: CHEBI:35488) Orexin Receptor Antagonist (Code: N0000191000) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 3A Inhibitors (Code: N0000190114) Neurotransmitter Agents (Code: D018377) Orexin Receptor Antagonists (Code: D000068796) Sleep Aids, Pharmaceutical (Code: D000068776) | 2014-08-13 FDA | 4S0V 4ZJ8 |
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| istradefylline | Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/16004599) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) None (Source: CHEMBL) | selective antagonist at the A2A receptor, used in the treatment of Parkinson's disease | Adenosine A2 Receptor Antagonists (Code: D058917) Neurotransmitter Agents (Code: D018377) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P1 Receptor Antagonists (Code: D058915) | 2013-03-8 PMDA | |
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| simetride | a analgesic agent indicated for low back pain, symptomatic neuralgia, headache, menstrual pain, pharyngalgia/earache due to inflammation, toothache, postoperative pain, combined with caffeine | 1965 PMDA | |
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| tedizolid phosphate | Staphylococcus aureus subsp. aureus (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/21502615) | Tedizolid phosphate is a prodrug that is converted by phosphatases to tedizolid, the microbiologically active moiety, following oral and intravenous administration. The antibacterial activity of tedizolid is mediated by binding to the 50S subunit of the bacterial ribosome resulting in inhibition of protein synthesis. Tedizolid inhibits bacterial protein synthesis through a mechanism of action different from that of other non-oxazolidinone class antibacterial drugs; therefore, cross-resistance between tedizolid and other classes of antibacterial drugs is unlikely. | prodrug (Code: CHEBI:50266) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Oxazolidinone Antibacterial (Code: N0000175495) Oxazolidinones (Code: N0000007568) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) | 2014-06-20 FDA | |
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| dexrabeprazole | Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/2154989) | None | 2007-06-13 CDSCO (INDIA) | 3PGL |
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| tavaborole | Trichophyton mentagrophytes (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/17588934) Trichophyton rubrum (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/17588934) Leucine--tRNA ligase, cytoplasmic (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P26637, gene: CDC60, swissprot: SYLC_YEAST) None (Source: CHEMBL) Leucine-tRNA ligase (Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892), class: Enzyme, accessions: F2SF18, gene: None, swissprot: F2SF18_TRIRC) None (Source: CHEMBL) | The mechanism of action of tavaborole is inhibition of fungal protein synthesis. Tavaborole inhibits protein synthesis by inhibition of an aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS).Tavaborole has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections. | Oxaborole Antifungal (Code: N0000191279) Protein Synthesis Inhibitors (Code: N0000000150) Boron Compounds (Code: N0000008253) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 2014-07-07 FDA | |
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| idelalisib | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Organism: Homo sapiens, class: Kinase, accessions: P48736, gene: PIK3CG, swissprot: PK3CG_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Organism: Homo sapiens, class: Kinase, accessions: P42338, gene: PIK3CB, swissprot: PK3CB_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) DNA-dependent protein kinase catalytic subunit (Organism: Homo sapiens, class: Kinase, accessions: P78527, gene: PRKDC, swissprot: PRKDC_HUMAN) None (Source: CHEMBL) | Idelalisib is an inhibitor of PI3K-delta kinase, which is expressed in normal and malignant B-cells. Idelalisib induced apoptosis and inhibited proliferation in cell lines derived from malignant B-cells and in primary tumor cells. Idelalisib inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and the CXCR4 and CXCR5 signaling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) Cytochrome P450 3A Inhibitors (Code: N0000190114) | 2014-07-23 FDA | 4XE0 |
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| ataluren | A nonsense mutation in DNA results in a premature stop codon within an mRNA. This premature stop codon in the mRNA causes disease by terminating translation before a full-length protein is generated. Ataluren enables ribosomal readthrough of mRNA containing such a premature stop codon, resulting in production of a full-length protein. | 2014-07-31 EMA | |
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| mebanazine | Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/5889715) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/5889715) | Mebanazine (trade name Actomol) is a monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was previously used as an antidepressant in the 1960s, but has since been discontinued. | |
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| ceritinib | Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: CHEMBL) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: CHEMBL) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: CHEMBL) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) None (Source: CHEMBL) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) None (Source: CHEMBL) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: CHEMBL) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: CHEMBL) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: CHEMBL) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: CHEMBL) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: CHEMBL) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) None (Source: CHEMBL) Transcription factor ETV6 (Organism: Homo sapiens, class: Transcription factor, accessions: P41212, gene: ETV6, swissprot: ETV6_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: CHEMBL) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) None (Source: CHEMBL) | Ceritinib is a kinase inhibitor. Targets of ceritinib inhibition identified in either biochemical or cellular assays at clinically relevant concentrations include ALK, insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (InsR), and ROS1. Among these, ceritinib is most active against ALK. Ceritinib inhibited autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells in in vitro and in vivo assays. | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Kinase Inhibitor (Code: N0000175605) Tyrosine Kinase Inhibitors (Code: N0000020001) Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) Protein Kinase Inhibitors (Code: D047428) | 2014-04-29 FDA | 4MKC |
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| umifenovir | an antiviral agent | 1990 Ministry of Health of the Russian Federation | 5T6N 5T6S |
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| furazidin | Nitrofuran derivative anti-infective agent used for urinary tract infections. | antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | 2007 Ministry of Health of the Russian Federation | |
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| naloxegol | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204760s000lbl.pdf) | A peripherally acting opioid receptor antagonist specific for mu-opioid receptors. Used to decrease the constipating effects of opioids. | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2014-09-16 FDA | |
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| gemigliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) inhibitor (Source: http://professional.diabetes.org/Content/Posters/2008/p502-P.pdf) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) None (Source: http://professional.diabetes.org/Content/Posters/2008/p502-P.pdf) | Dipeptidyl Peptidase IV Inhibitors; orally active small molecule for the treatment of type II diabetes | 2012-06-27 Korean Food and Drug Administration (KFDA) | |
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| eliglustat | Ceramide glucosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q16739, gene: UGCG, swissprot: CEGT_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22058426) | Eliglustat tartrate is a small molecule inhibitor of glucosylceramide synthase that resembles the ceramide substrate for the enzyme. Gaucher disease is caused by a deficiency of the lysosomal enzyme acid beta-glucosidase. Acid beta-glucosidase catalyzes the conversion of the sphingolipid glucocerebroside into glucose and ceramide. The enzymatic deficiency causes an accumulation of glucosylceramide (GL-1) primarily in the lysosomal compartment of macrophages, giving rise to foam cells or "Gaucher cells". | Glucosylceramide Synthase Inhibitor (Code: N0000175783) Glucosylceramide Synthase Inhibitors (Code: N0000020019) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Enzyme Inhibitors (Code: D004791) | 2014-08-19 FDA | |
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| ethacizine | Ethacizine is an antiarrhythmic. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| octisalate | None | None FDA | |
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| omarigliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24660890) Dipeptidyl peptidase 4 (Organism: Mus musculus, class: Enzyme, accessions: P28843, gene: Dpp4, swissprot: DPP4_MOUSE) None (SOURCE: CHEMBL) | None | 2015-09-28 PMDA | |
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| apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Organism: Homo sapiens, class: Enzyme, accessions: Q08499, gene: PDE4D, swissprot: PDE4D_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19256507) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) inhibitor (Source: IUPHAR) cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Organism: Homo sapiens, class: Enzyme, accessions: Q08493, gene: PDE4C, swissprot: PDE4C_HUMAN) inhibitor (Source: IUPHAR) | Apremilast is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism(s) by which apremilast exerts its therapeutic action in psoriatic arthritis patients and psoriasis patients is not well defined. | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2014-03-21 FDA | |
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| empagliflozin | Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/glucose cotransporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q2M3M2, gene: SLC5A9, swissprot: SC5A9_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/glucose cotransporter 5 (Organism: Homo sapiens, class: Transporter, accessions: A0PJK1, gene: SLC5A10, swissprot: SC5AA_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/myo-inositol cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: Q8WWX8, gene: SLC5A11, swissprot: SC5AB_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) | Empagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion. | hypoglycemic agent (Code: CHEBI:35526) Sodium-Glucose Cotransporter 2 Inhibitor (Code: N0000187059) Sodium-Glucose Transporter 2 Inhibitors (Code: N0000187058) Hypoglycemic Agents (Code: D007004) | 2014-05-22 EMA | |
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| aripiprazole lauroxil | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) partial agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) partial agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) agonist (Source: IUPHAR) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) agonist (Source: IUPHAR) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) agonist (Source: IUPHAR) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) antagonist (Source: IUPHAR) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) agonist (Source: IUPHAR) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) agonist (Source: IUPHAR) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) agonist (Source: IUPHAR) | prodrug of aripiprazole, following intramuscular injection is converted by enzyme-mediated hydrolysis to N-hydroxymethyl aripiprazole which is then hydrolyzed to aripiprazole | H1-receptor antagonist (Code: CHEBI:37955) second generation antipsychotic (Code: CHEBI:65191) serotonergic agonist (Code: CHEBI:35941) prodrug (Code: CHEBI:50266) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 2015-10-05 FDA | |
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| amino(diphenylhydantoin) valeric acid | None | |
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| meprotixol | None | |
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| vintafolide | has significant antiproliferative activity and tolerability, thus lending support to an ongoing phase 1 trial for the treatment of advanced malignancies. In 2014 company stopped a late-stage study (PROCEED) of vintafolide in treating ovarian cancer on the recommendation of a data safety monitoring board, saying that the drug failed to improve progression-free survival. | 2012-02-09 EMA | |
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| etilefrine pivalate | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/4396765) | None | |
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| laquinimod | Laquinimod is an immunomodulator developed by Teva for oral treatment for multiple sclerosis. | 2013-07-05 Ministry of Health of the Russian Federation | |
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| iodohippurate sodium I125 | None | radiopharmaceutical (Code: CHEBI:35232) | |
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| luliconazole | Candida albicans (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10461840) Aspergillus fumigatus (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10461840) Trichophyton mentagrophytes (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10461840) Trichophyton rubrum (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10461840) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) inhibitor (Source: CHEMBL) | an antifungal that belongs to the azole class, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase, inhibition of this enzyme's activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) | 2013-11-14 FDA | |
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| iodohippurate sodium I131 | is a diagnostic aid in determining renal function, renal blood flow, ar urinary tract obstruction, and a renal imaging agent (Discontinued) | radiopharmaceutical (Code: CHEBI:35232) | 1968-05-24 FDA | |
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| laninamivir octanoate hydrate | Neuraminidase (Organism: Influenza A virus (A/RI/5+/1957(H2N2)), class: Enzyme, accessions: Q194T1, gene: None, swissprot: Q194T1_9INFA) None (Source: CHEMBL) | an antiviral agent | 2010-07-29 PMDA | 3TI4 3TIB |
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| peramivir | Neuraminidase (Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1), class: Enzyme, accessions: P03468, gene: NA, swissprot: NRAM_I34A1) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206426lbl.pdf) Neuraminidase (Organism: Influenza B virus (strain B/Lee/1940), class: Enzyme, accessions: P03474, gene: NA, swissprot: NRAM_INBLE) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206426lbl.pdf) Neuraminidase (Organism: Influenza A virus (strain A/Brevig Mission/1/1918 H1N1), class: Enzyme, accessions: Q9IGQ6, gene: NA, swissprot: NRAM_I18A0) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206426lbl.pdf) | Peramivir is an inhibitor of influenza virus neuraminidase, an enzyme that releases viral particles from the plasma membrane of infected cells. | EC 3.2.1.18 (exo-alpha-sialidase) inhibitor (Code: CHEBI:52425) antiviral drug (Code: CHEBI:36044) Neuraminidase Inhibitor (Code: N0000175524) Neuraminidase Inhibitors (Code: N0000175436) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) | 2014-12-19 FDA | 1L7F 1L7G 1L7H 2F10 2HTU 3K37 3K39 4MWV 4MX0 |
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| florbetaben F18 | Amyloid beta A4 protein (Organism: Homo sapiens, class: Unclassified, accessions: P05067, gene: APP, swissprot: A4_HUMAN) None (Source: CHEMBL) | Florbetaben F18 is a F18-labeled stilbene derivative, which binds to beta-amyloid plaques in the brain. The F 18 isotope produces a positron signal that is detected by a PET scanner. | Radioactive Diagnostic Agent (Code: N0000177914) Positron Emitting Activity (Code: N0000175869) | 2014-03-19 FDA | |
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| delamanid | an antitubercular agent | 2014-04-28 EMA | |
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| nordefrin | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) | A norepinephrine derivative used as a vasoconstrictor agent. | Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662) | |
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| tasimelteon | Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22640220) Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22640220) | an agonist at melatonin MT1 and MT2 receptors, these receptors are thought to be involved in the control of circadian rhythms | Melatonin Receptor Agonist (Code: N0000175743) Melatonin Receptor Agonists (Code: N0000000250) | 2014-01-31 FDA | |
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| rifamycin | Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) None (Source: CHEMBL) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) None (Source: CHEMBL) Solute carrier organic anion transporter family member 1A2 (Organism: Homo sapiens, class: Unclassified, accessions: P46721, gene: SLCO1A2, swissprot: SO1A2_HUMAN) inhibitor (Source: IUPHAR) Solute carrier organic anion transporter family member 1B1 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y6L6, gene: SLCO1B1, swissprot: SO1B1_HUMAN) inhibitor (Source: IUPHAR) | None | antitubercular agent (Code: CHEBI:33231) Antirheumatic Agents (Code: D018501) | 1988-10-03 Swissmedic (Switzerland) | |
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| olodaterol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20371707) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20371707) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20371707) | a long-acting beta2-adrenergic agonist (LABA), activation of beta2 receptors in the airways results in a stimulation of intracellular adenyl cyclase, an enzyme that mediates the synthesis of cyclic-3',5' adenosine monophosphate (cAMP), elevated levels of cAMP induce bronchodilation by relaxation of airway smooth muscle cells | beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic beta2-Agonists (Code: N0000009922) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 2014-07-31 FDA | |
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| umeclidinium | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/19317446) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19317446) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19317446) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: IUPHAR) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) None (Source: IUPHAR) | a long-acting antimuscarinic agent with similar affinity to the subtypes of muscarinic receptors M1 to M5, in the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation | muscarinic antagonist (Code: CHEBI:48876) Anticholinergic (Code: N0000175574) Cholinergic Antagonists (Code: N0000175370) | 2013-12-18 FDA | |
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| vortioxetine | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/22171087) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204447s004lbl.pdf) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 3A (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563, gene: Htr3a, swissprot: 5HT3A_RAT) None (Source: CHEMBL) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) None (Source: CHEMBL) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: CHEMBL) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) None (Source: CHEMBL) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) None (Source: CHEMBL) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) None (Source: CHEMBL) 5-hydroxytryptamine receptor 1D (Organism: Rattus norvegicus, class: GPCR, accessions: P28565, gene: Htr1d, swissprot: 5HT1D_RAT) antagonist (Source: IUPHAR) | an anti-anxiety agent, 5-HT1A receptor agonist, 5-HT3 receptor antagonist, and 5-HT7 receptor antagonist | antidepressant (Code: CHEBI:35469) anxiolytic drug (Code: CHEBI:35474) serotonergic agonist (Code: CHEBI:35941) serotonergic antagonist (Code: CHEBI:48279) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin 5-HT1 Receptor Antagonists (Code: D058829) Serotonin 5-HT3 Receptor Antagonists (Code: D058831) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Serotonin Receptor Agonists (Code: D017366) Serotonin Uptake Inhibitors (Code: D017367) Tranquilizing Agents (Code: D014149) | 2013-09-30 FDA | |
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| riociguat | cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Organism: Homo sapiens, class: Enzyme, accessions: Q9NP56, gene: PDE7B, swissprot: PDE7B_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19263460) Guanylate cyclase soluble subunit beta-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q02153, gene: GUCY1B3, swissprot: GCYB1_HUMAN) positive allosteric modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/19263460) | guanylate cyclase stimulator | antihypertensive agent (Code: CHEBI:35674) Guanylate Cyclase Stimulators (Code: N0000190484) Soluble Guanylate Cyclase Stimulator (Code: N0000190485) Enzyme Activators (Code: D020536) | 2013-10-08 FDA | |
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| sofosbuvir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20845908) NS5B protein (Organism: Hepatitis C virus, class: Enzyme, accessions: Q8JXU8, gene: NS5B, swissprot: Q8JXU8_9HEPC) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204671s000lbl.pdf) | Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator | prodrug (Code: CHEBI:50266) antiviral drug (Code: CHEBI:36044) Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor (Code: N0000191493) RNA Replicase Inhibitors (Code: N0000191258) Nucleoside Analog (Code: N0000175459) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 2013-12-06 FDA | |
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| simeprevir | Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205123s008lbl.pdf) Cathepsin S (Organism: Homo sapiens, class: Enzyme, accessions: P25774, gene: CTSS, swissprot: CATS_HUMAN) None (Source: CHEMBL) Hepatitis C virus serine protease, NS3/NS4A (Organism: Hepatitis C virus, class: Enzyme, accessions: A3EZI9|D2K2A8, gene: NS3|NS4A, swissprot: A3EZI9_9HEPC|D2K2A8_9HEPC) inhibitor (Source: CHEMBL) Nonstructural protein NS3-4A (Organism: Hepatitis C virus, class: Unclassified, accessions: A0A0K1CY61, gene: None, swissprot: A0A0K1CY61_9HEPC) None (Source: CHEMBL) | Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS. | Hepatitis C Virus NS3/4A Protease Inhibitor (Code: N0000182639) HCV NS3/4A Protease Inhibitors (Code: N0000182638) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 2013-11-22 FDA | 3KEE |
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| ipidacrine | Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/11256231) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/11256231) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) None (Source: CHEMBL) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: CHEMBL) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) None (Source: CHEMBL) | do not confuse with neuromedin | None Ministry of Health of the Russian Federation | |
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| macitentan | Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22862294) Endothelin B receptor (Organism: Homo sapiens, class: GPCR, accessions: P24530, gene: EDNRB, swissprot: EDNRB_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22862294) | an endothelin receptor antagonist that prevents the binding of ET-1 to both ETA and ETB receptors, macitentan displays high affinity and sustained occupancy of the ET receptors in human pulmonary arterial smooth muscle cells | endothelin receptor antagonist (Code: CHEBI:51451) antihypertensive agent (Code: CHEBI:35674) orphan drug (Code: CHEBI:71031) Endothelin A Receptor Antagonists (Code: D065130) Endothelin B Receptor Antagonists (Code: D065131) Endothelin Receptor Antagonists (Code: D065128) | 2013-10-18 FDA | |
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| ibrutinib | Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17154430) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/17154430) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: CHEMBL) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Tec (Organism: Homo sapiens, class: Kinase, accessions: P42680, gene: TEC, swissprot: TEC_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) | Ibrutinib is a small-molecule inhibitor of BTK. Ibrutinib forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. BTK's role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion. Nonclinical studies show that ibrutinib inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro. | antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) | 2013-11-13 FDA | 4IFG 4RZ7 5P9I 5YU9 5P9J |
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| dolutegravir | Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) None (source: CHEMBL) | Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle. | Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor (Code: N0000175887) Multidrug and Toxin Extrusion Transporter 1 Inhibitors (Code: N0000191423) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Integrase Inhibitors (Code: D019428) | 2013-08-12 FDA | 3S3M 3S3N 3S3O |
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| dimethyl fumarate | Kelch-like ECH-associated protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q14145, gene: KEAP1, swissprot: KEAP1_HUMAN) inhibitor (Source: CHEMBL) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) None (SOURCE: CHEMBL) | A fumarate derivative that is used as a DERMATOLOGIC AGENT in the treatment of PSORIASIS and SKIN DISEASES. It also may be used as an IMMUNOSUPPRESSIVE AGENT in the treatment of MULTIPLE SCLEROSIS. | immunomodulator (Code: CHEBI:50846) antipsoriatic (Code: CHEBI:50748) Dermatologic Agents (Code: D003879) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Radiation-Sensitizing Agents (Code: D011838) | 2013-03-27 FDA | |
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| canagliflozin | Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: CHEMBL) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: CHEMBL) | A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal glucose reabsorption. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES. | hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) Sodium-Glucose Cotransporter 2 Inhibitor (Code: N0000187059) Sodium-Glucose Transporter 2 Inhibitors (Code: N0000187058) P-Glycoprotein Inhibitors (Code: N0000185503) | 2013-03-29 FDA | |
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| glycerol phenylbutyrate | glutamine (Organism: None, class: Amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203284s001lbl.pdf) | for treating urea cycle disorders | 2013-02-01 FDA | |
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| pomalidomide | Protein cereblon (Organism: Homo sapiens, class: Cytosolic other, accessions: Q96SW2, gene: CRBN, swissprot: CRBN_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/25043012) | an immunomodulator with antineoplastic and angiogenesis inhibitor activity | angiogenesis inhibitor (Code: CHEBI:48422) antineoplastic agent (Code: CHEBI:35610) immunomodulator (Code: CHEBI:50846) Thalidomide Analog (Code: N0000184014) Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) Immunologic Factors (Code: D007155) | 2013-02-08 FDA | 4CI3 4TZU 4V2Z |
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| quifenadine | blocks histamine H1-receptors in the peripheral tissues, and activates enzyme diaminoxidase (histaminase), due to this decreasing the histamine concentration in tissues | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | 2006-02-17 Ministry of Health of the Russian Federation | |
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| ospemifene | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) modulator (Source: CHEMBL) | an estrogen agonist/antagonist with tissue selective effects, its biological actions are mediated through binding to estrogen receptors, this binding results in activation of estrogenic pathways in some tissues (agonism) and blockade of estrogenic pathways in others (antagonism) | estrogen receptor modulator (Code: CHEBI:50739) antineoplastic agent (Code: CHEBI:35610) anti-inflammatory agent (Code: CHEBI:67079) Estrogen Agonist/Antagonist (Code: N0000175826) Selective Estrogen Receptor Modulators (Code: N0000000168) | 2013-02-26 FDA | |
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| cetyl alcohol | has been used for eczema, skin irritations; RN given refers to parent cpd; structure | 1990-08-02 FDA | 2UUU 2UUV 4QUW 4RC5 4RC7 |
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| levobetaxolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) antagonist (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN)antagonist (Source: IUPHAR) | a cardioselective (beta-1-adrenergic) receptor blocking agent that does not have significant membrane-stabilizing (local anesthetic) activity and is devoid of intrinsic sympathomimetic action | 2000-02-23 FDA | |
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| regorafenib | Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: CHEMBL) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) inhibitor (Source: CHEMBL) Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) inhibitor (Source: CHEMBL) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) None (Source: CHEMBL) | a small molecule inhibitor of multiple membrane-bound and intracellular kinases involved in normal cellular functions and in pathologic processes such as oncogenesis, tumor angiogenesis, and maintenance of the tumor microenvironment | antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) | 2012-09-27 FDA | |
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| tedisamil | Potassium voltage-gated channel subfamily A member 7 (Organism: Mus musculus, class: Unclassified, accessions: Q17ST2, gene: Kcna7, swissprot: KCNA7_MOUSE) blocker (Source: IUPHAR) | a multiple potassium channel blocker which blocks the rapid (IKr), slow (IKs) and ultrarapid (IKur) components of the delayed rectifier potassium current, the transient outward potassium current (Ito) and the ATP (IKATP) sensitive and the acetylcholine-activated (IKACH) potassium currents | Anti-Arrhythmia Agents (Code: D000889) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Protective Agents (Code: D020011) | 2008-05-21 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| metabutethamine | None | |
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| metamizole | Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/25765567) | A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE | prodrug (Code: CHEBI:50266) non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) peripheral nervous system drug (Code: CHEBI:49110) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antipyretics (Code: D058633) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1949-05-10 Swissmedic (Switzerland) | |
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| methylatropine | Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor DM1 (Organism: Drosophila melanogaster, class: GPCR, accessions: P16395, gene: mAChR-A, swissprot: ACM1_DROME) None (Source: CHEMBL) | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| creatine | An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine. | None FDA | 1V7Z 3A6J 3B6R |
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| benzoin | Cocaine esterase (Organism: Homo sapiens, class: Enzyme, accessions: O00748, gene: CES2, swissprot: EST2_HUMAN) None (Source: CHEMBL) Liver carboxylesterase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23141, gene: CES1, swissprot: EST1_HUMAN) None (Source: CHEMBL) | A white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide and used in organic syntheses. This should not be confused with benzoin gum from STYRAX. | None FDA | |
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| octinoxate | a UV filter compound | 1992-12-07 FDA | |
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| avobenzone | Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) | causes allergic or photoallergic contact dermatitis; structure given in first source | Cosmetics (Code: D003358) Dermatologic Agents (Code: D003879) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) Sunscreening Agents (Code: D013473) | 1992-12-07 FDA | |
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| methyl salicylate | used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990 | flavouring agent (Code: CHEBI:35617) insect attractant (Code: CHEBI:24850) Antirheumatic Agents (Code: D018501) Fixatives (Code: D005404) | 2008-02-20 FDA | |
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| tafluprost | Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) agonist (Source: CHEMBL) | a prostaglandin analog is a selective FP prostanoid receptor agonist which is believed to reduce intraocular pressure by increasing uveoscleral outflow | Prostaglandin Analog (Code: N0000175454) Prostaglandin Receptor Agonists (Code: N0000000106) Increased Prostaglandin Activity (Code: N0000009526) Prostaglandins (Code: N0000007706) | 2012-02-10 FDA | |
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| Ioflupane I-123 | a radiopharmaceutical indicated for striatal dopamine transporter visualization using single photon emission computed tomography (SPECT) brain imaging to assist in the evaluation of adult patients with suspected Parkinsonian syndromes (PS) | radiopharmaceutical (Code: CHEBI:35232) Radioactive Diagnostic Agent (Code: N0000177914) Radiopharmaceutical Activity (Code: N0000000205) | 2011-01-14 FDA | |
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| telbivudine | Protein P (Organism: Hepatitis B virus, class: Polyprotein, accessions: Q9IF40, gene: P, swissprot: Q9IF40_HBV) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022011s013lbl.pdf) | has an activity against hepatitis B virus | antiviral drug (Code: CHEBI:36044) Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175656) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 2006-10-25 FDA | 3HP1 3QEO |
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| formaldehyde | A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anti-Infective Agents (Code: D000890) Disinfectants (Code: D004202) Fixatives (Code: D005404) | None FDA | |
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| mequinol | Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) inhibitor (Source: CHEMBL) | a substrate for the enzyme tyrosinase and acts as a competitive inhibitor of the formation of melanin precursors, depigmenting agent; RN given refers to parent cpd | Depigmenting Activity (Code: N0000175851) Melanin Synthesis Inhibitors (Code: N0000175850) Skin Lightening Agent (Code: N0000175855) Antineoplastic Agents (Code: D000970) Antioxidants (Code: D000975) Protective Agents (Code: D020011) | 1999-12-10 FDA | 4Z3G 4Z3H 5K1M |
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| vilazodone | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: IUPHAR) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: IUPHAR) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: IUPHAR) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) agonist (Source: IUPHAR) 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) agonist (Source: IUPHAR) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) agonist (Source: IUPHAR) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) None (Source: CHEMBL) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) None (Source: CHEMBL) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: CHEMBL) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 1D (Organism: Rattus norvegicus, class: GPCR, accessions: P28565, gene: Htr1d, swissprot: 5HT1D_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) None (Source: CHEMBL) 5-hydroxytryptamine receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: Q62758, gene: Htr4, swissprot: 5HT4R_RAT) None (Source: CHEMBL) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) None (Source: CHEMBL) | A benzofuran, indole, and piperazine derivative that functions as a SEROTONIN UPTAKE INHIBITOR and partial SEROTONIN 5-HT1 RECEPTOR AGONIST. It is used as an ANTIDEPRESSIVE AGENT. | antidepressant (Code: CHEBI:35469) serotonergic agonist (Code: CHEBI:35941) serotonin uptake inhibitor (Code: CHEBI:50949) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Serotonin Uptake Inhibitors (Code: D017367) | 2011-01-21 FDA | |
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| pirfenidone | pyridone, indicated for the treatment of idiopathic pulmonary fibrosis | non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) Pyridone (Code: N0000191420) Pyridones (Code: N0000007575) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antineoplastic Agents (Code: D000970) Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2008-09-16 PMDA | |
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| axitinib | Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: CHEMBL) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) None (Source: CHEMBL) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: CHEMBL) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: CHEMBL) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: CHEMBL) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: CHEMBL) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: CHEMBL) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: CHEMBL) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: CHEMBL) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) None (Source: CHEMBL) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) None (Source: CHEMBL) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: CHEMBL) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: CHEMBL) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: CHEMBL) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) None (Source: CHEMBL) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: CHEMBL) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: CHEMBL) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: CHEMBL) Myosin-IIIa (Organism: Homo sapiens, class: Kinase, accessions: Q8NEV4, gene: MYO3A, swissprot: MYO3A_HUMAN) None (Source: CHEMBL) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: CHEMBL) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: CHEMBL) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) None (Source: CHEMBL) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: CHEMBL) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: CHEMBL) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: CHEMBL) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: CHEMBL) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: CHEMBL) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) None (Source: CHEMBL) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) None (Source: CHEMBL) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: CHEMBL) Dual specificity testis-specific protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q15569, gene: TESK1, swissprot: TESK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase MRCK beta (Organism: Homo sapiens, class: Kinase, accessions: Q9Y5S2, gene: CDC42BPB, swissprot: MRCKB_HUMAN) None (Source: CHEMBL) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: CHEMBL) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) None (Source: CHEMBL) Activin receptor type-2B (Organism: Homo sapiens, class: Kinase, accessions: Q13705, gene: ACVR2B, swissprot: AVR2B_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: CHEMBL) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: CHEMBL) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) None (Source: CHEMBL) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: CHEMBL) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: CHEMBL) Hormonally up-regulated neu tumor-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: P57058, gene: HUNK, swissprot: HUNK_HUMAN) None (Source: CHEMBL) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PAK 4 (Organism: Homo sapiens, class: Kinase, accessions: O96013, gene: PAK4, swissprot: PAK4_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: CHEMBL) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: CHEMBL) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: CHEMBL) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) None (Source: CHEMBL) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: CHEMBL) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: CHEMBL) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: CHEMBL) | oral Angiogenesis Inhibitor that inhibits the tyrosine kinase activities of both VEGFR and PDGFRbeta | antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) | 2012-01-27 FDA | 4AG8 4AGC 4TWP 4WA9 |
|
|
| ingenol mebutate | Protein kinase C delta type (Organism: Homo sapiens, class: Kinase, accessions: Q05655, gene: PRKCD, swissprot: KPCD_HUMAN) activator (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C alpha type (Organism: Homo sapiens, class: Kinase, accessions: P17252, gene: PRKCA, swissprot: KPCA_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C beta type (Organism: Homo sapiens, class: Kinase, accessions: P05771, gene: PRKCB, swissprot: KPCB_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C gamma type (Organism: Homo sapiens, class: Kinase, accessions: P05129, gene: PRKCG, swissprot: KPCG_HUMAN) activator (Source: IUPHAR) | protein kinase C agonist and antineoplastic | antineoplastic agent (Code: CHEBI:35610) Cell Death Inducer (Code: N0000184015) Increased Cellular Death (Code: N0000009176) | 2012-01-23 FDA | |
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| icatibant | B1 bradykinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P46663, gene: BDKRB1, swissprot: BKRB1_HUMAN) antagonist (Source: IUPHAR) B2 bradykinin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25023, gene: Bdkrb2, swissprot: BKRB2_RAT) None (Source: CHEMBL) B2 bradykinin receptor (Organism: Cavia porcellus, class: GPCR, accessions: O70526, gene: BDKRB2, swissprot: BKRB2_CAVPO) None (Source: CHEMBL) B2 bradykinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30411, gene: BDKRB2, swissprot: BKRB2_HUMAN) antagonist (Source: CHEMBL) B2 bradykinin receptor (Organism: Mus musculus, class: Unclassified, accessions: P32299, gene: Bdkrb2, swissprot: BKRB2_MOUSE) antagonist (Source: IUPHAR) | a potent bradykinin (B2) receptor antagonist; WIN 65365 is an L-Tic(7) stereoisomer | beta-adrenergic antagonist (Code: CHEBI:35530) Bradykinin B2 Receptor Antagonist (Code: N0000182965) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Bradykinin B2 Receptor Antagonists (Code: D065094) Bradykinin Receptor Antagonists (Code: D065168) Complement Inactivating Agents (Code: D051056) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2008-07-11 EMA | |
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| crizotinib | SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) None (Source: CHEMBL) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: CHEMBL) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) None (Source: CHEMBL) Muscle, skeletal receptor tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: O15146, gene: MUSK, swissprot: MUSK_HUMAN) None (Source: CHEMBL) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: CHEMBL) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) None (Source: CHEMBL) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) agonist (source: CHEMBL) Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92630, gene: DYRK2, swissprot: DYRK2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: CHEMBL) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) inhibitor (Source: CHEMBL) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) None (Source: CHEMBL) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase NIM1 (Organism: Homo sapiens, class: Kinase, accessions: Q8IY84, gene: NIM1K, swissprot: NIM1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q6ZN16, gene: MAP3K15, swissprot: M3K15_HUMAN) None (Source: CHEMBL) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) None (Source: CHEMBL) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 11B (Organism: Homo sapiens, class: Kinase, accessions: P21127, gene: CDK11B, swissprot: CD11B_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase Nek7 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDX7, gene: NEK7, swissprot: NEK7_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: CHEMBL) AarF domain-containing protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96D53, gene: COQ8B, swissprot: COQ8B_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) None (Source: CHEMBL) Angiopoietin-1 receptor (Organism: Mus musculus, class: Kinase, accessions: Q02858, gene: Tek, swissprot: TIE2_MOUSE) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: CHEMBL) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ABL1 (Organism: Mus musculus, class: Kinase, accessions: P00520, gene: Abl1, swissprot: ABL1_MOUSE) None (Source: CHEMBL) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) None (Source: CHEMBL) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: CHEMBL) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: CHEMBL) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) None (Source: CHEMBL) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) None (Source: CHEMBL) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase DCLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8N568, gene: DCLK2, swissprot: DCLK2_HUMAN) None (Source: CHEMBL) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) None (Source: CHEMBL) Insulin receptor-related protein (Organism: Homo sapiens, class: Kinase, accessions: P14616, gene: INSRR, swissprot: INSRR_HUMAN) None (Source: CHEMBL) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: CHEMBL) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: CHEMBL) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) None (Source: CHEMBL) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: CHEMBL) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: CHEMBL) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: CHEMBL) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) None (Source: CHEMBL) Macrophage-stimulating protein receptor (Organism: Homo sapiens, class: Kinase, accessions: Q04912, gene: MST1R, swissprot: RON_HUMAN) None (Source: CHEMBL) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 7 (Organism: Homo sapiens, class: Kinase, accessions: Q15375, gene: EPHA7, swissprot: EPHA7_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: CHEMBL) Inhibitor of nuclear factor kappa-B kinase subunit beta (Organism: Homo sapiens, class: Kinase, accessions: O14920, gene: IKBKB, swissprot: IKKB_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase Nek9 (Organism: Homo sapiens, class: Kinase, accessions: Q8TD19, gene: NEK9, swissprot: NEK9_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: CHEMBL) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) None (Source: CHEMBL) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) None (Source: CHEMBL) LIM domain kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53667, gene: LIMK1, swissprot: LIMK1_HUMAN) None (Source: CHEMBL) NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Organism: Homo sapiens, class: Kinase, accessions: P06748|Q9UM73, gene: ALK|NPM1, swissprot: ALK_HUMAN|NPM_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) None (Source: CHEMBL) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) None (Source: CHEMBL) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) None (Source: CHEMBL) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: CHEMBL) Dual specificity testis-specific protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q15569, gene: TESK1, swissprot: TESK1_HUMAN) None (Source: CHEMBL) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) None (Source: CHEMBL) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: CHEMBL) Activin receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: Q04771, gene: ACVR1, swissprot: ACVR1_HUMAN) None (Source: CHEMBL) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) None (Source: CHEMBL) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: CHEMBL) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) None (Source: CHEMBL) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: CHEMBL) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: CHEMBL) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) None (Source: CHEMBL) Peripheral plasma membrane protein CASK (Organism: Homo sapiens, class: Kinase, accessions: O14936, gene: CASK, swissprot: CSKP_HUMAN) None (Source: CHEMBL) Dual serine/threonine and tyrosine protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q6XUX3, gene: DSTYK, swissprot: DUSTY_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: CHEMBL) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13233, gene: MAP3K1, swissprot: M3K1_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) None (Source: CHEMBL) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: CHEMBL) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: CHEMBL) Uncharacterized serine/threonine-protein kinase SBK3 (Organism: Homo sapiens, class: Kinase, accessions: P0C264, gene: SBK3, swissprot: SBK3_HUMAN) None (Source: CHEMBL) Macrophage-stimulating protein receptor (Organism: Mus musculus, class: Kinase, accessions: Q62190, gene: Mst1r, swissprot: RON_MOUSE) None (Source: CHEMBL) Activin receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: P36896, gene: ACVR1B, swissprot: ACV1B_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: CHEMBL) TGF-beta receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: P36897, gene: TGFBR1, swissprot: TGFR1_HUMAN) None (Source: CHEMBL) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: CHEMBL) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) None (Source: CHEMBL) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: CHEMBL) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: CHEMBL) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: CHEMBL) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: CHEMBL) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: CHEMBL) LIM domain kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P53671, gene: LIMK2, swissprot: LIMK2_HUMAN) None (Source: CHEMBL) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) inhibitor (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) None (Source: CHEMBL) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: CHEMBL) Cyclin-dependent kinase 11A (Organism: Homo sapiens, class: Kinase, accessions: Q9UQ88, gene: CDK11A, swissprot: CD11A_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: CHEMBL) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) None (Source: CHEMBL) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) None (Source: CHEMBL) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: CHEMBL) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: CHEMBL) Mitogen-activated protein kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q13164, gene: MAPK7, swissprot: MK07_HUMAN) None (Source: CHEMBL) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: CHEMBL) | Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), ROS1 (c-ros), and Recepteur d'Origine Nantais (RON). Translocations can affect the ALK gene resulting in the expression of oncogenic fusion proteins. The formation of ALK fusion proteins results in activation and dysregulation of the gene's expression and signaling which can contribute to increased cell proliferation and survival in tumors expressing these proteins. Crizotinib demonstrated concentration-dependent inhibition of ALK, ROS1, and c-Met phosphorylation in cell-based assays using tumor cell lines and demonstrated antitumor activity in mice bearing tumor xenografts that expressed echinoderm microtubule-associated protein-like 4 (EML4)- or nucleophosmin (NPM)-ALK fusion proteins or c-Met. | antineoplastic agent (Code: CHEBI:35610) biomarker (Code: CHEBI:59163) Kinase Inhibitor (Code: N0000175605) Cytochrome P450 3A Inhibitors (Code: N0000190114) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Cytochrome P450 2B6 Inhibitors (Code: N0000182139) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Cation Transporter 1 Inhibitors (Code: N0000191265) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) | 2011-08-26 FDA | 2WGJ 2XP2 2YFX 3ZBF 4ANQ 4ANS 4C9W 5AAA 5AAB 5AAC 4C9X |
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| deferiprone | iron (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021825s003lbl.pdf) | a chelating agent with an affinity for ferric ion (iron III) indicated for the treatment of patients with transfusional iron overload due to thalassemia syndromes | protective agent (Code: CHEBI:50267) Iron Chelating Activity (Code: N0000000144) Iron Chelator (Code: N0000175522) Chelating Agents (Code: D002614) Iron Chelating Agents (Code: D007502) Sequestering Agents (Code: D064449) | 2011-10-14 FDA | |
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| hydroxyprogesterone caproate | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) None (Source: Drug Matrix) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: Drug Matrix) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: Drug Matrix) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) None (Source: Drug Matrix) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) None (Source: Drug Matrix) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) None (Source: Drug Matrix) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) None (Source: CHEMBL) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) None (Source: CHEMBL) | None | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) | 1974-12-26 FDA | |
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| talbutal | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: CHEMBL) | None | 1960 FDA | |
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| ethanol | GABA A receptor alpha-4/beta-2/delta (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P47870|P48169, gene: GABRA4|GABRB2|GABRD, swissprot: GBRA4_HUMAN|GBRB2_HUMAN|GBRD_HUMAN) Glycine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P23416, gene: GLRA2, swissprot: GLRA2_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) | A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. | antiseptic drug (Code: CHEBI:48218) polar solvent (Code: CHEBI:48354) central nervous system depressant (Code: CHEBI:35488) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Solvents (Code: D012997) | 1946-01-17 FDA | |
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| guanidine | Voltage-gated potassium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43525|O43526|O95259|P16389|P17658|P22001|P22459|P22460|P48547|P51787|P56696|Q03721|Q09470|Q12809|Q14003|Q14721|Q16322|Q6PIU1|Q8NCM2|Q8TAE7|Q8TDN1|Q8TDN2|Q92953|Q96KK3|Q96L42|Q96PR1|Q96RP8|Q9BQ31|Q9H252|Q9H3M0|Q9NR82|Q9NS40|Q9NSA2|Q9NZV8|Q9UIX4|Q9UJ96|Q9UK17|Q9ULD8|Q9ULS6|Q9UQ05, gene: KCNA1|KCNA10|KCNA2|KCNA3|KCNA4|KCNA5|KCNA6|KCNA7|KCNB1|KCNB2|KCNC1|KCNC2|KCNC3|KCNC4|KCND1|KCND2|KCND3|KCNF1|KCNG1|KCNG2|KCNG3|KCNG4|KCNH1|KCNH2|KCNH3|KCNH4|KCNH5|KCNH6|KCNH7|KCNH8|KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5|KCNS1|KCNS2|KCNS3|KCNV1|KCNV2, swissprot: KCA10_HUMAN|KCNA1_HUMAN|KCNA2_HUMAN|KCNA3_HUMAN|KCNA4_HUMAN|KCNA5_HUMAN|KCNA6_HUMAN|KCNA7_HUMAN|KCNB1_HUMAN|KCNB2_HUMAN|KCNC1_HUMAN|KCNC2_HUMAN|KCNC3_HUMAN|KCNC4_HUMAN|KCND1_HUMAN|KCND2_HUMAN|KCND3_HUMAN|KCNF1_HUMAN|KCNG1_HUMAN|KCNG2_HUMAN|KCNG3_HUMAN|KCNG4_HUMAN|KCNH1_HUMAN|KCNH2_HUMAN|KCNH3_HUMAN|KCNH4_HUMAN|KCNH5_HUMAN|KCNH6_HUMAN|KCNH7_HUMAN|KCNH8_HUMAN|KCNQ1_HUMAN|KCNQ2_HUMAN|KCNQ3_HUMAN|KCNQ4_HUMAN|KCNQ5_HUMAN|KCNS1_HUMAN|KCNS2_HUMAN|KCNS3_HUMAN|KCNV1_HUMAN|KCNV2_HUMAN) blocker (Source: CHEMBL) | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. | Acetylcholine Releasing Agent (Code: N0000175772) Increased Acetylcholine Activity (Code: N0000009079) | 1939-10-02 FDA | |
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| corticorelin ovine | used in diagnosis of adrenocortical insufficiency & Cushing's syndrome; AA sequence given in first source; MF C205-H339-N59-O63-S; RN given refers to triflutate salt; RN for parent cpd not avail 3/94 | diagnostic agent (Code: CHEBI:33295) | 1996-05-23 FDA | |
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| vinyl ether | a clear, nearly colorless, volatile liquid which was used as an inhalation anesthetic | Anesthetics (Code: D000777) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | |
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| propiolactone | Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic. | Anti-Infective Agents (Code: D000890) Disinfectants (Code: D004202) | 1981 FDA | |
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| ethyl chloride | A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine. | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| glycine | Sodium- and chloride-dependent glycine transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P48067, gene: SLC6A9, swissprot: SC6A9_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) None (Source: CHEMBL) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) None (Source: CHEMBL) | A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. | nutraceutical (Code: CHEBI:50733) hepatoprotective agent (Code: CHEBI:62868) NMDA receptor agonist (Code: CHEBI:64571) Glycine Agents (Code: D018684) Neurotransmitter Agents (Code: D018377) | 1976-05-25 FDA | |
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| acetohydroxamic acid | Urease (Organism: Canavalia ensiformis, class: Enzyme, accessions: P07374, gene: None, swissprot: UREA_CANEN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Bacterial urease (Organism: Escherichia coli, class: Enzyme, accessions: Q03282|Q03283|Q03284, gene: ureA|ureB|ureC, swissprot: URE1_ECOLX|URE2_ECOLX|URE3_ECOLX) inhibitor (Source: CHEMBL) | urease inhibitor | Urease Inhibitor (Code: N0000175611) Urease Inhibitors (Code: N0000175087) Enzyme Inhibitors (Code: D004791) | 1983-05-31 FDA | 5N5J 5N5K 4H9M 4A7B 3KEC 3LIK 3LIL 3LJG 3LKA 3DPF 3BA0 2OZR 2OW9 2HU6 1Y93 1UTT 1UTZ 1OS2 1E9Y 4UBP 1AM6 1FWE |
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| hydroxycarbamide | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Ribonucleoside-diphosphate reductase subunit M2 (Organism: Homo sapiens, class: Enzyme, accessions: P31350, gene: RRM2, swissprot: RIR2_HUMAN) inhibitor (Source: CHEMBL) Ribonucleoside-diphosphate reductase large subunit (Organism: Homo sapiens, class: Enzyme, accessions: P23921, gene: RRM1, swissprot: RIR1_HUMAN) inhibitor (Source: CHEMBL) | An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. | antineoplastic agent (Code: CHEBI:35610) immunomodulator (Code: CHEBI:50846) Antimetabolite (Code: N0000180853) Urea (Code: N0000006999) Antineoplastic Agents (Code: D000970) Antisickling Agents (Code: D000986) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1967-12-07 FDA | 3UB9 2GEH |
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| propylene glycol | A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. | protic solvent (Code: CHEBI:48356) Pharmaceutic Aids (Code: D010592) Pharmaceutical Vehicles (Code: D014677) Solvents (Code: D012997) | None FDA | |
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| mercaptamine | cystine (Organism: None, class: Unnatural amino acid, accessions: None, gene: None, swissprot: None) | A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS. | Cystine Depleting Agent (Code: N0000187051) Cystine Disulfide Reduction (Code: N0000175549) Cystine Depleting Agents (Code: D065104) | 1994-08-15 FDA | |
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| dimethyl sulfoxide | A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. | polar aprotic solvent (Code: CHEBI:48358) non-narcotic analgesic (Code: CHEBI:35481) antidote (Code: CHEBI:50247) Antioxidants (Code: D000975) Cryoprotective Agents (Code: D003451) Free Radical Scavengers (Code: D016166) Protective Agents (Code: D020011) Solvents (Code: D012997) | 1978-04-04 FDA | |
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| fomepizole | Alcohol dehydrogenase (Organism: Equus caballus, class: Enzyme, accessions: P00327|P00328, gene: None, swissprot: ADH1E_HORSE|ADH1S_HORSE) None (Source: CHEMBL) Alcohol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P00325|P00326|P07327, gene: ADH1A|ADH1B|ADH1C, swissprot: ADH1A_HUMAN|ADH1B_HUMAN|ADH1G_HUMAN) inhibitor (Source: CHEMBL) | alcohol dehyrogenase inhibitor | antidote (Code: CHEBI:50247) protective agent (Code: CHEBI:50267) Antidotes (Code: D000931) Protective Agents (Code: D020011) | 1997-12-04 FDA | |
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| piperazine | Gamma-aminobutyric acid receptor subunit beta (Organism: Caenorhabditis elegans, class: Ion channel, accessions: O18276, gene: gab-1, swissprot: GBRB_CAEEL) | has anthelmintic action | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) | 1954-07-12 FDA | |
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| cyverine | None | |
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| deanol | Creatine transporter (Organism: Rattus norvegicus, class: Unclassified, accessions: P28570, gene: Slc6a8, swissprot: SC6A8_RAT) None (Source: CHEMBL) High affinity choline transporter 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BGY9, gene: Slc5a7, swissprot: SC5A7_MOUSE) None (Source: CHEMBL) | An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood. | curing agent (Code: CHEBI:75358) Anti-Dyskinesia Agents (Code: D018726) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | 1963 YEAR INTRODUCED | |
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| benzyl alcohol | A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring, benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate | solvent (Code: CHEBI:46787) fragrance (Code: CHEBI:48318) Pediculicide (Code: N0000181811) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2009-04-09 FDA | 2AMQ 2HOB 2Q6F 3D23 3IWM 4II8 5EB5 5EU8 5GWY 5GWZ |
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| lactic acid | A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) | 2006-10-25 FDA | 5WBF 5XR2 5I8T 4QO8 4N3G 4N3N 4M49 4JNK 2Y4J 2WNZ 3KB6 2ZZV 2ZZW 2ZZX 2P1E 2NLI 2IMP 2FN7 2FLT 1W3Q 1C0K 1QH9 1C0Q 1C0R |
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| glycerol | A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent. | solvent (Code: CHEBI:46787) detergent (Code: CHEBI:27780) Non-Standardized Chemical Allergen (Code: N0000185370) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Increased IgG Production (Code: N0000185001) Allergens (Code: N0000171131) Glycerol (Code: N0000006566) Cryoprotective Agents (Code: D003451) Protective Agents (Code: D020011) Solvents (Code: D012997) | 1982-05-06 FDA | 3H3N |
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| methylpentynol | a tertiary hexanol with hypnotic/sedative and anticonvulsant effects, was used for the treatment of insomnia | |
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| secretin porcine | stimulate pancreatic ductal cells to secrete pancreas fluid in large volumes that contain bicarbonate | 2002-04-04 FDA | |
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| loxoprofen | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: KEGG DRUG) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: KEGG DRUG) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) prodrug (Code: CHEBI:50266) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2005-12-22 PMDA | |
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| aminopicoline | None | 2EUT 3E67 |
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| glutaral | One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative. | cross-linking reagent (Code: CHEBI:50684) Anti-Infective Agents (Code: D000890) Cross-Linking Reagents (Code: D003432) Disinfectants (Code: D004202) Fixatives (Code: D005404) Indicators and Reagents (Code: D007202) | |
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| cycloserine | Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, NMDA 2C (Organism: Rattus norvegicus, class: Ion channel, accessions: Q00961, gene: Grin2c, swissprot: NMDE3_RAT) None (Source: CHEMBL) Alanine racemase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WQA8, gene: alr, swissprot: ALR_MYCTO) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) None (Source: CHEMBL) D-alanine--D-alanine ligase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WP31, gene: ddl, swissprot: DDL_MYCTU) inhibitor (Source: CHEMBL) Alanine racemase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WQA9, gene: alr, swissprot: ALR_MYCTU) inhibitor (Source: CHEMBL) Glutamate receptor ionotropic, NMDA 2D (Organism: Homo sapiens, class: Ion channel, accessions: O15399, gene: GRIN2D, swissprot: NMDE4_HUMAN) Glutamate receptor ionotropic, NMDA 3B (Organism: Homo sapiens, class: Ion channel, accessions: O60391, gene: GRIN3B, swissprot: NMD3B_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Glutamate receptor ionotropic, NMDA 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q05586, gene: GRIN1, swissprot: NMDZ1_HUMAN) Glutamate receptor ionotropic, NMDA 2A (Organism: Homo sapiens, class: Ion channel, accessions: Q12879, gene: GRIN2A, swissprot: NMDE1_HUMAN) Glutamate receptor ionotropic, NMDA 2B (Organism: Homo sapiens, class: Ion channel, accessions: Q13224, gene: GRIN2B, swissprot: NMDE2_HUMAN) Glutamate receptor ionotropic, NMDA 2C (Organism: Homo sapiens, class: Ion channel, accessions: Q14957, gene: GRIN2C, swissprot: NMDE3_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) | Antibiotic substance produced by Streptomyces garyphalus. | NMDA receptor agonist (Code: CHEBI:64571) antiinfective agent (Code: CHEBI:35441) antitubercular agent (Code: CHEBI:33231) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antibiotics, Antitubercular (Code: D000904) Antimetabolites (Code: D000963) Antitubercular Agents (Code: D000995) Noxae (Code: D009676) Renal Agents (Code: D012076) | 1964-06-29 FDA | 1PB9 1XQL |
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| aminobutyric acid | Gamma-aminobutyric acid receptor subunit rho-1 (Organism: Homo sapiens, class: Ion channel, accessions: P24046, gene: GABRR1, swissprot: GBRR1_HUMAN) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P30531, gene: SLC6A1, swissprot: SC6A1_HUMAN) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 3 (Organism: Homo sapiens, class: Transporter, accessions: P48066, gene: SLC6A11, swissprot: S6A11_HUMAN) None (Source: CHEMBL) Sodium- and chloride-dependent betaine transporter (Organism: Homo sapiens, class: Transporter, accessions: P48065, gene: SLC6A12, swissprot: S6A12_HUMAN) None (Source: CHEMBL) Gamma-aminobutyric acid receptor subunit gamma-1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P23574, gene: Gabrg1, swissprot: GBRG1_RAT) None (Source: CHEMBL) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P23576, gene: Gabra2, swissprot: GBRA2_RAT) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 1 (Organism: Rattus norvegicus, class: Transporter, accessions: P23978, gene: Slc6a1, swissprot: SC6A1_RAT) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31646, gene: Slc6a13, swissprot: S6A13_RAT) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 1 (Organism: Mus musculus, class: Transporter, accessions: P31648, gene: Slc6a1, swissprot: SC6A1_MOUSE) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 2 (Organism: Mus musculus, class: Unclassified, accessions: P31649, gene: Slc6a13, swissprot: S6A13_MOUSE) None (Source: CHEMBL) Sodium- and chloride-dependent GABA transporter 3 (Organism: Mus musculus, class: Unclassified, accessions: P31650, gene: Slc6a11, swissprot: S6A11_MOUSE) None (Source: CHEMBL) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P62813, gene: Gabra1, swissprot: GBRA1_RAT) None (Source: CHEMBL) | The most common inhibitory neurotransmitter in the central nervous system. | GABA Agents (Code: D018682) Neurotransmitter Agents (Code: D018377) | None FDA | |
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| choline | Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: CHEMBL) Creatine transporter (Organism: Rattus norvegicus, class: Unclassified, accessions: P28570, gene: Slc6a8, swissprot: SC6A8_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: CHEMBL) High affinity choline transporter 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BGY9, gene: Slc5a7, swissprot: SC5A7_MOUSE) None (Source: CHEMBL) | A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. | Antimetabolites (Code: D000963) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Lipotropic Agents (Code: D008082) Nootropic Agents (Code: D018697) | None FDA | |
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| nicotinyl alcohol | Alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1964 CDSCO (INDIA) | 1R16 |
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| resorcinol | Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Dicentrarchus labrax, class: Unclassified, accessions: Q2PCB5, gene: ca, swissprot: Q2PCB5_DICLA) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) | an antiseptic and disinfectant used for temporary relief of itching | None FDA | 1EVR 1QIZ 2OLY 2OLZ 2OM0 2OM1 2OMH 2OMI 2W44 3AQT 3ZU1 4AJX 4DM3 4E49 4QOO 4Z10 |
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| hydroquinone | Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Carbonic anhydrase (Organism: Dicentrarchus labrax, class: Unclassified, accessions: Q2PCB5, gene: ca, swissprot: Q2PCB5_DICLA) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) | skin depigmentation agent | skin lightening agent (Code: CHEBI:85046) Depigmenting Activity (Code: N0000175851) Melanin Synthesis Inhibitor (Code: N0000175854) Melanin Synthesis Inhibitors (Code: N0000175850) Antioxidants (Code: D000975) Mutagens (Code: D009153) Noxae (Code: D009676) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) | 2002-01-18 FDA | 3ZOD 3ZOF 4E3H 4QOP 5FSE 5I3A 5I3B |
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| histamine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) None (Source: CHEMBL) Histamine H2 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P47747, gene: HRH2, swissprot: HRH2_CAVPO) None (Source: CHEMBL) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) None (Source: CHEMBL) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) None (Source: CHEMBL) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) agonist (Source: CHEMBL) Histamine H4 receptor (Organism: Mus musculus, class: GPCR, accessions: Q91ZY2, gene: Hrh4, swissprot: HRH4_MOUSE) None (Source: CHEMBL) Histamine H3 receptor (Organism: Mus musculus, class: GPCR, accessions: P58406, gene: Hrh3, swissprot: HRH3_MOUSE) None (Source: CHEMBL) Histamine H4 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q91ZY1, gene: Hrh4, swissprot: HRH4_RAT) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: PDSP) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) None (Source: CHEMBL) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) None (Source: CHEMBL) Histamine H4 receptor (Organism: Cavia porcellus, class: Unclassified, accessions: Q91ZY3, gene: HRH4, swissprot: Q91ZY3_CAVPO) None (Source: CHEMBL) Histamine H3 receptor (Organism: Cavia porcellus, class: Unclassified, accessions: Q9JI35, gene: HRH3, swissprot: HRH3_CAVPO) None (Source: CHEMBL) Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) None (Source: CHEMBL) | An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Histamine Agents (Code: D018494) Histamine Agonists (Code: D017442) Neurotransmitter Agents (Code: D018377) | 1939-04-25 FDA | 1AVN 1IKE 1JQD 1KAR 1NP1 1QFT 1QFV 1U18 2QEB 2X45 3BU1 3G7X 3RXH 4XMF |
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| betazole | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) agonist (Source: CHEMBL) | A histamine H2 agonist used clinically to test gastric secretory function. | histamine agonist (Code: CHEBI:35678) diagnostic agent (Code: CHEBI:33295) gastrointestinal drug (Code: CHEBI:55324) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Agonists (Code: D017442) Neurotransmitter Agents (Code: D018377) | 1982-01-01 FDA | |
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| thiamazole | Thyroid peroxidase (Organism: Homo sapiens, class: Enzyme, accessions: P07202, gene: TPO, swissprot: PERT_HUMAN) inhibitor (Source: CHEMBL) Dopamine beta-hydroxylase (Organism: Bos taurus, class: Unclassified, accessions: P15101, gene: DBH, swissprot: DOPO_BOVIN) None (Source: CHEMBL) Lactoperoxidase (Organism: Bos taurus, class: Enzyme, accessions: P80025, gene: LPO, swissprot: PERL_BOVIN) None (Source: CHEMBL) Lactoperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P22079, gene: LPO, swissprot: PERL_HUMAN) None (Source: CHEMBL) | A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. | antithyroid drug (Code: CHEBI:50671) Thyroid Hormone Synthesis Inhibitor (Code: N0000175918) Thyroid Hormone Synthesis Inhibitors (Code: N0000175917) Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1950-06-21 FDA | 2GVC 4IG5 5FF1 5GSN |
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| tuaminoheptane | an adrenergic agent used as a nasal decongestant in the form of the base (for inhalation) or the sulfate salt (topical solution) | 1990-05-25 Swissmedic (Switzerland) | |
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| methylhexaneamine | sympathomimetic aliphatic amine with vasoconstrictor activity | |
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| cacodylic acid | An arsenical that has been used as a dermatologic agent and as an herbicide. | Herbicides (Code: D006540) Pesticides (Code: D010575) | |
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| fumaric acid | Egl nine homolog 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9GZT9, gene: EGLN1, swissprot: EGLN1_HUMAN) None (Source: CHEMBL) | see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters | food acidity regulator (Code: CHEBI:64049) | |
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| succinic acid | Egl nine homolog 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9GZT9, gene: EGLN1, swissprot: EGLN1_HUMAN) None (Source: CHEMBL) | A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) | anti-ulcer drug (Code: CHEBI:49201) nutraceutical (Code: CHEBI:50733) | |
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| betaine | homocysteine (Organism: None, class: Unnatural amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020576s010lbl.pdf) | A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341) | Methylating Activity (Code: N0000175804) Methylating Agent (Code: N0000175805) Antimetabolites (Code: D000963) Gastrointestinal Agents (Code: D005765) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Lipotropic Agents (Code: D008082) | 1996-10-25 FDA | 4H5W 3T2J 5HIJ |
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| aminohydroxybutyric acid | None | |
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| oxymethurea | None | |
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| noxytiolin | Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for burns. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | |
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| trometamol | An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424) | Buffers (Code: D002021) Excipients (Code: D005079) Pharmaceutic Aids (Code: D010592) Pharmaceutical Vehicles (Code: D014677) | 1965-12-16 FDA | 5WZM |
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| cysteine | Cystine/glutamate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q9UPY5, gene: SLC7A11, swissprot: XCT_HUMAN) None (Source: CHEMBL) | A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. | 1986-10-22 FDA | 4Z82 4XF1 |
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| nicotinamide | NAD-dependent deacetylase sirtuin 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q9NTG7, gene: SIRT3, swissprot: SIR3_HUMAN) None (Source: CHEMBL) Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) None (Source: CHEMBL) NAD-dependent protein deacetylase sirtuin-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q8IXJ6, gene: SIRT2, swissprot: SIR2_HUMAN) None (Source: CHEMBL) NAD-dependent protein deacylase sirtuin-5, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9NXA8, gene: SIRT5, swissprot: SIR5_HUMAN) None (Source: CHEMBL) NAD-dependent deacetylase HST2 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53686, gene: HST2, swissprot: HST2_YEAST) None (Source: CHEMBL) Putative silent information regulator 2 (Organism: Leishmania infantum, class: Unclassified, accessions: Q8I6E4, gene: SIR2RP1, swissprot: Q8I6E4_LEIIN) None (Source: CHEMBL) NAD-dependent protein deacetylase sirtuin-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q96EB6, gene: SIRT1, swissprot: SIR1_HUMAN) None (Source: CHEMBL) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) Hydroxycarboxylic acid receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P49019, gene: HCAR3, swissprot: HCAR3_HUMAN) Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Organism: Homo sapiens, class: Enzyme, accessions: Q15274, gene: QPRT, swissprot: NADC_HUMAN) Nicotinamide N-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P40261, gene: NNMT, swissprot: NNMT_HUMAN) | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | neuroprotective agent (Code: CHEBI:63726) anti-inflammatory agent (Code: CHEBI:67079) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vitamin B Complex (Code: D014803) | 1953-02-20 FDA | 5V4V 1DMA 1ISI 1ISM 1R15 1YC2 1YC5 2A15 2C8A 2E5D 2H4J 2HJH 2OD9 2OTV 2QHF 2QQG 2R6V 2R9J 2Z77 2ZB7 3DZG 3I9J 3NN0 3O94 3ROD 3ROP 3ROZ 3U9H 3UPW 3ZJQ 4A3U 4AE1 4HYF 4RMJ 4YP2 5CF9 5J6H 5M10 5N3H 5VW4 5VW5 5VW9 5WQP |
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| nicotinic acid | Hydroxycarboxylic acid receptor 2 (Organism: Mus musculus, class: GPCR, accessions: Q9EP66, gene: Hcar2, swissprot: HCAR2_MOUSE) Hydroxycarboxylic acid receptor 2 (Organism: Rattus norvegicus, class: GPCR, accessions: Q80Z39, gene: Hcar2, swissprot: HCAR2_RAT) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) Nicotinamide phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P43490, gene: NAMPT, swissprot: NAMPT_HUMAN) Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Organism: Homo sapiens, class: Enzyme, accessions: Q15274, gene: QPRT, swissprot: NADC_HUMAN) Nicotinamide N-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P40261, gene: NNMT, swissprot: NNMT_HUMAN) Hydroxycarboxylic acid receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P49019, gene: HCAR3, swissprot: HCAR3_HUMAN) | A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. | B vitamin (Code: CHEBI:75769) vasodilator agent (Code: CHEBI:35620) antidote (Code: CHEBI:50247) antilipemic drug (Code: CHEBI:35679) Nicotinic Acid (Code: N0000175594) Nicotinic Acids (Code: N0000007641) Antimetabolites (Code: D000963) Cardiovascular Agents (Code: D002317) Growth Substances (Code: D006133) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vasodilator Agents (Code: D014665) Vitamin B Complex (Code: D014803) | 1957-07-24 FDA | 1D0V 1FSL 1ICR 1ICU 1ICV 1JHA 1JHO 1JHQ 1JHR 1JHV 1JHY 1L4N 1L5K 1L5L 1L5M 1LH6 2F7F 2LH6 2WT9 2XRH 3CI8 3HRD 3I45 3O14 3R2J 3WAR 4BN9 4KQI |
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| mecysteine | None | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | |
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| pyrazinamide | Cyclopropane mycolic acid synthase 1 (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WPB6, gene: cmaA1, swissprot: CMAS1_MYCTO) Amidase; Nicotinamidase; Nicotinamidase/pyrazinamidase; Pyrazinamidase; Pyrazinamidase/nicotinamidase; Pyrazinamidase/nicotinamidase PncA (Organism: Mycobacterium tuberculosis, class: Enzyme, accessions: Q50575, gene: pncA, swissprot: Q50575_MYCTX) 3-oxoacyl-ACP synthase; Fatty acid synthase Fas; Probable fatty acid synthase Fas (Fatty acid synthetase) (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P95029, gene: fas, swissprot: P95029_MYCTU) inhibitor (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) | A pyrazine that is used therapeutically as an antitubercular agent. | antitubercular agent (Code: CHEBI:33231) prodrug (Code: CHEBI:50266) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) | 1971-06-03 FDA | 3R4X 3R55 5FPD |
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| guaiacol | Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) | An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747) | expectorant (Code: CHEBI:77035) | 3HT9 4A6Z 4A78 4G05 4QOQ |
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| dimercaprol | An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning. | Metal Chelating Activity (Code: N0000175472) Metal Chelator (Code: N0000175473) Chelating Agents (Code: D002614) Sequestering Agents (Code: D064449) | 1946-05-06 FDA | |
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| foscarnet | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) DNA polymerase catalytic subunit (Organism: Human cytomegalovirus (strain AD169), class: Enzyme, accessions: P08546, gene: UL54, swissprot: DPOL_HCMVA) Reverse transcriptase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9WKE8, gene: reverse transcriptas, swissprot: Q9WKE8_9HIV1) | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. | antiviral drug (Code: CHEBI:36044) DNA Polymerase Inhibitors (Code: N0000020060) Pyrophosphate Analog (Code: N0000175469) Pyrophosphate Analog DNA Polymerase Inhibitor (Code: N0000175470) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Chelating Activity (Code: N0000000087) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1991-09-27 FDA | 5HP1 2IT4 X ray |
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| fluroxene | None | |
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| phloroglucinol | Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) None (Source: CHEMBL) | A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent. | Indicators and Reagents (Code: D007202) | 4HDK 5MG5 |
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| orazamide | None | 1971 YEAR INTRODUCED | 3CL8 |
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| chloral hydrate | A hypnotic and sedative used in the treatment of INSOMNIA. | sedative (Code: CHEBI:35717) general anaesthetic (Code: CHEBI:38869) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1840-01-01 YEAR INTRODUCED | |
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| pyrithione | Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) None (Source: CHEMBL) | split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| thiouracil | Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis. | Antithyroid Agents (Code: D013956) Cardiovascular Agents (Code: D002317) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Vasodilator Agents (Code: D014665) | 4WS8 |
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| dichloroacetic acid | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q15120, gene: PDK3, swissprot: PDK3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q16654, gene: PDK4, swissprot: PDK4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q15118, gene: PDK1, swissprot: PDK1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q15119, gene: PDK2, swissprot: PDK2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) | A derivative of ACETIC ACID that contains two CHLORINE atoms attached to its methyl group. | |
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| flucytosine | Thymidylate synthase (Organism: Cryptococcus neoformans var. neoformans serotype D (strain B-3501A), class: Enzyme, accessions: P0CS13, gene: TMP1, swissprot: TYSY_CRYNB) inhibitor (Source: CHEMBL) Thymidylate synthase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P12461, gene: TMP1, swissprot: TYSY_CANAL) inhibitor (Source: DRUGBANK) ATP-dependent molecular chaperone HSP82 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Cytosolic other, accessions: P02829, gene: HSP82, swissprot: HSP82_YEAST) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | A fluorinated cytosine analog that is used as an antifungal agent. Inside the fungal cell, flucytosine is rapidly converted to fluorouracil by the enzyme cytosine deaminase. Fluorouracil exerts its antifungal activity through the subsequent conversion into several active metabolites, which inhibit protein synthesis by being falsely incorporated into fungal RNA or interfere with the biosynthesis of fungal DNA through the inhibition of the enzyme thymidylate synthetase | prodrug (Code: CHEBI:50266) Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antifungal (Code: N0000175467) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antimetabolites (Code: D000963) Noxae (Code: D009676) | 1971-11-26 FDA | 4R88 |
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| vigabatrin | Gamma-amino-N-butyrate transaminase (Organism: Rattus norvegicus, class: Unclassified, accessions: P50554, gene: Abat, swissprot: GABT_RAT) None (Source: CHEMBL) 4-aminobutyrate aminotransferase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P80404, gene: ABAT, swissprot: GABT_HUMAN) inhibitor (Source: CHEMBL) | The precise mechanism of vigabatrin's anti-seizure effect is unknown, but it is believed to be the result of its action as an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the metabolism of the inhibitory neurotransmitter GABA. This action results in increased levels of GABA in the central nervous system. | anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) GABA Agents (Code: D018682) Neurotransmitter Agents (Code: D018377) | 2009-08-21 FDA | |
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| metformin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) None (Source: CHEMBL) Mitochondrial complex I (NADH dehydrogenase) (Organism: Homo sapiens, class: Enzyme, accessions: O00217|O00483|O14561|O15239|O43181|O43674|O43676|O43677|O43678|O43920|O75251|O75306|O75380|O75438|O75489|O95139|O95167|O95168|O95169|O95178|O95182|O95298|O95299|O96000|P03886|P03891|P03897|P03901|P03905|P03915|P03923|P17568|P19404|P28331|P49821|P51970|P56181|P56556|Q16718|Q16795|Q86Y39|Q8N183|Q9BU61|Q9NRX3|Q9NX14|Q9P032|Q9P0J0|Q9UI09|Q9Y375|Q9Y6M9, gene: MT-ND1|MT-ND2|MT-ND3|MT-ND4|MT-ND4L|MT-ND5|MT-ND6|NDUFA1|NDUFA10|NDUFA11|NDUFA12|NDUFA13|NDUFA2|NDUFA3|NDUFA4|NDUFA4L2|NDUFA5|NDUFA6|NDUFA7|NDUFA8|NDUFA9|NDUFAB1|NDUFAF1|NDUFAF2|NDUFAF3|NDUFAF4|NDUFB1|NDUFB10|NDUFB11|NDUFB2|NDUFB3|NDUFB4|NDUFB5|NDUFB6|NDUFB7|NDUFB8|NDUFB9|NDUFC1|NDUFC2|NDUFS1|NDUFS2|NDUFS3|NDUFS4|NDUFS5|NDUFS6|NDUFS7|NDUFS8|NDUFV1|NDUFV2|NDUFV3, swissprot: ACPM_HUMAN|CIA30_HUMAN|MIMIT_HUMAN|NDUA1_HUMAN|NDUA2_HUMAN|NDUA3_HUMAN|NDUA4_HUMAN|NDUA5_HUMAN|NDUA6_HUMAN|NDUA7_HUMAN|NDUA8_HUMAN|NDUA9_HUMAN|NDUAA_HUMAN|NDUAB_HUMAN|NDUAC_HUMAN|NDUAD_HUMAN|NDUB1_HUMAN|NDUB2_HUMAN|NDUB3_HUMAN|NDUB4_HUMAN|NDUB5_HUMAN|NDUB6_HUMAN|NDUB7_HUMAN|NDUB8_HUMAN|NDUB9_HUMAN|NDUBA_HUMAN|NDUBB_HUMAN|NDUC1_HUMAN|NDUC2_HUMAN|NDUF3_HUMAN|NDUF4_HUMAN|NDUS1_HUMAN|NDUS2_HUMAN|NDUS3_HUMAN|NDUS4_HUMAN|NDUS5_HUMAN|NDUS6_HUMAN|NDUS7_HUMAN|NDUS8_HUMAN|NDUV1_HUMAN|NDUV2_HUMAN|NDUV3_HUMAN|NU1M_HUMAN|NU2M_HUMAN|NU3M_HUMAN|NU4LM_HUMAN|NU4M_HUMAN|NU5M_HUMAN|NU6M_HUMAN|NUA4L_HUMAN) inhibitor (Source: CHEMBL) 5'-AMP-activated protein kinase subunit beta-1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y478, gene: PRKAB1, swissprot: AAKB1_HUMAN) None (Source: WOMBAT_PK) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) | an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization | hypoglycemic agent (Code: CHEBI:35526) Biguanide (Code: N0000175565) Biguanides (Code: N0000007698) Hypoglycemic Agents (Code: D007004) | 1995-03-03 FDA | 5G5J |
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| octodrine | None | |
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| oxiniacic acid | None | |
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| fluorouracil | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) inhibitor (Source: CHEMBL) Thymidylate synthase (Organism: Mus musculus, class: Enzyme, accessions: P07607, gene: Tyms, swissprot: TYSY_MOUSE) None (Source: CHEMBL) Uracil phosphoribosyltransferase (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P0A8F0, gene: upp, swissprot: UPP_ECOLI) None (Source: CHEMBL) ATP-binding cassette sub-family C member 11 (Organism: Homo sapiens, class: Transporter, accessions: Q96J66, gene: ABCC11, swissprot: ABCCB_HUMAN) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) | a nucleoside metabolic inhibitor that interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA); these affect rapidly growing cells and may lead to cell death. | radiosensitizing agent (Code: CHEBI:132992) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) | 1962-04-25 FDA | 1H7X 1RXC 1UPF 3KVR 3KVV 3NAI 3NBQ 4E1V 4O0O 4TXN 4WRY 4WRZ 4WS0 4WS1 5IAO 5SXC |
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| aminolevulinic acid | A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS. | antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) dermatologic drug (Code: CHEBI:50177) prodrug (Code: CHEBI:50266) Porphyrin Precursor (Code: N0000175846) Porphyrinogens (Code: N0000171207) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) | 1999-12-03 FDA | |
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| leucine | An essential branched-chain amino acid important for hemoglobin formation. | None FDA | |
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| aminocaproic acid | Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) Tissue-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00750, gene: PLAT, swissprot: TPA_HUMAN) | An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. | antifibrinolytic drug (Code: CHEBI:48675) hematologic agent (Code: CHEBI:50248) Antifibrinolytic Agent (Code: N0000175634) Decreased Fibrinolysis (Code: N0000175632) Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Fibrin Modulating Agents (Code: D050299) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) | 1964-06-03 FDA | |
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| paraldehyde | A hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment. (From Martindale, The Extra Pharmacopoeia, 30th ed, p608-9) | sedative (Code: CHEBI:35717) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| ornithine | G-protein coupled receptor family C group 6 member A (Organism: Homo sapiens, class: GPCR, accessions: Q5T6X5, gene: GPRC6A, swissprot: GPC6A_HUMAN) | An amino acid produced in the urea cycle by the splitting off of urea from arginine. | |
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| prenderol | None | |
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| aspartic acid | Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) None (Source: CHEMBL) Aspartate--tRNA ligase, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P14868, gene: DARS, swissprot: SYDC_HUMAN) Aspartyl/asparaginyl beta-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: Q12797, gene: ASPH, swissprot: ASPH_HUMAN) Aspartate aminotransferase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00505, gene: GOT2, swissprot: AATM_HUMAN) Aminoacylase-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q03154, gene: ACY1, swissprot: ACY1_HUMAN) Argininosuccinate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P00966, gene: ASS1, swissprot: ASSY_HUMAN) Asparagine synthetase [glutamine-hydrolyzing] (Organism: Homo sapiens, class: Enzyme, accessions: P08243, gene: ASNS, swissprot: ASNS_HUMAN) Aspartoacylase (Organism: Homo sapiens, class: Enzyme, accessions: P45381, gene: ASPA, swissprot: ACY2_HUMAN) Aspartate aminotransferase, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P17174, gene: GOT1, swissprot: AATC_HUMAN) Calcium-binding mitochondrial carrier protein Aralar1 (Organism: Homo sapiens, class: Unclassified, accessions: O75746, gene: SLC25A12, swissprot: CMC1_HUMAN) Calcium-binding mitochondrial carrier protein Aralar2 (Organism: Homo sapiens, class: Unclassified, accessions: Q9UJS0, gene: SLC25A13, swissprot: CMC2_HUMAN) | One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. | None FDA | |
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| timonacic | None | hepatoprotective agent (Code: CHEBI:62868) antidote (Code: CHEBI:50247) | 1SAV 2WW7 5FF3 5UU2 5UU4 |
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| tranylcypromine | Cationic trypsin (Organism: Bos taurus, class: Enzyme, accessions: P00760, gene: None, swissprot: TRY1_BOVIN) None (Source: CHEMBL) Lysine-specific histone demethylase 1A (Organism: Homo sapiens, class: Enzyme, accessions: O60341, gene: KDM1A, swissprot: KDM1A_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: CHEMBL) Cytochrome P450 2A6 (Organism: Homo sapiens, class: Enzyme, accessions: P11509, gene: CYP2A6, swissprot: CP2A6_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN)) None (Source: PDSP) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN)) None (Source: PDSP) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: CHEMBL) Lysine-specific histone demethylase 1B (Organism: Homo sapiens, class: Enzyme, accessions: Q8NB78, gene: KDM1B, swissprot: KDM1B_HUMAN) None (Source: CHEMBL) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) | A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) | antidepressant (Code: CHEBI:35469) anxiolytic drug (Code: CHEBI:35474) Monoamine Oxidase Inhibitor (Code: N0000175744) Anti-Anxiety Agents (Code: D014151) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1961-02-21 FDA | 3MDR |
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| adenine | Phosphatidylinositol 4-kinase, PI4K (Organism: Homo sapiens, class: Kinase, accessions: P42356|Q8TCG2|Q9BTU6|Q9UBF8, gene: PI4K2A|PI4K2B|PI4KA|PI4KB, swissprot: P4K2A_HUMAN|P4K2B_HUMAN|PI4KA_HUMAN|PI4KB_HUMAN) None (Source: CHEMBL) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) None (Source: CHEMBL) | A purine base and a fundamental unit of ADENINE NUCLEOTIDES. | None FDA | |
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| acetanilide | a phenylacetamide; use ACETANILIDES for the plural group meaning of the singular term | analgesic (Code: CHEBI:35480) | |
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| levamfetamine | Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (source: CHEMBL) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (source: CHEMBL) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (source: CHEMBL) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) None (source: CHEMBL) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (source: CHEMBL) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) None (source: CHEMBL) | None | 2AOF 2AOH 2AOI 2AOJ |
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| dexamfetamine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) releasing agent (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) None (Source: CHEMBL) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: CHEMBL) Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) inhibitor (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) Cocaine- and amphetamine-regulated transcript protein (Organism: Homo sapiens, class: Transcription factor, accessions: Q16568, gene: CARTPT, swissprot: CART_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: PDSP) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) | The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic. | Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 1955-09-09 FDA | 4LAR 4XP9 |
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| amfetamine | Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22037049) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Mus musculus, class: Transporter, accessions: Q60857, gene: Slc6a4, swissprot: SC6A4_MOUSE) None (Source: CHEMBL) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 2B (Organism: Rattus norvegicus, class: GPCR, accessions: P30994, gene: Htr2b, swissprot: 5HT2B_RAT) None (Source: CHEMBL) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) None (Source: CHEMBL) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) None (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) releasing agent (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) releasing agent (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: PDSP) Cocaine- and amphetamine-regulated transcript protein (Organism: Homo sapiens, class: Transcription factor, accessions: Q16568, gene: CARTPT, swissprot: CART_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. | sympathomimetic agent (Code: CHEBI:35524) dopaminergic agent (Code: CHEBI:48560) adrenergic agent (Code: CHEBI:37962) dopamine uptake inhibitor (Code: CHEBI:51039) adrenergic uptake inhibitor (Code: CHEBI:35640) bronchodilator agent (Code: CHEBI:35523) Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1955-09-09 FDA | 2AOF 2AOH 2AOI 2AOJ 4LAR 4XP9 |
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| allopurinol | Xanthine dehydrogenase/oxidase (Organism: Bos taurus, class: Enzyme, accessions: P80457, gene: XDH, swissprot: XDH_BOVIN) None (Source: CHEMBL) Xanthine dehydrogenase/oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22985, gene: Xdh, swissprot: XDH_RAT) None (Source: CHEMBL) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) inhibitor (Source: CHEMBL) Hypoxanthine-guanine phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P00492, gene: HPRT1, swissprot: HPRT_HUMAN) | A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms. | gout suppressant (Code: CHEBI:35845) Xanthine Oxidase Inhibitor (Code: N0000175698) Xanthine Oxidase Inhibitors (Code: N0000000206) Antimetabolites (Code: D000963) Antioxidants (Code: D000975) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) Free Radical Scavengers (Code: D016166) Gout Suppressants (Code: D006074) Noxae (Code: D009676) | 1966-08-19 FDA | |
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| pentaerythritol | None | 4RMF |
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| phenylpropanol | None | |
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| phenelzine | Membrane primary amine oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q16853, gene: AOC3, swissprot: AOC3_HUMAN) None (source: CHEMBL) Lysine-specific histone demethylase 1A (Organism: Homo sapiens, class: Enzyme, accessions: O60341, gene: KDM1A, swissprot: KDM1A_HUMAN) None (source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (source: PDSP) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (source: CHEMBL) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (source: DRUG MATRIX) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) None (source: DRUG MATRIX) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) None (source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (source: CHEMBL) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) None (source: DRUG MATRIX) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) None (source: CHEMBL) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) None (source: CHEMBL) Cytochrome P450 2C8 (Organism: Homo sapiens, class: Enzyme, accessions: P10632, gene: CYP2C8, swissprot: CP2C8_HUMAN) inhibitor (source: IUPHAR) | One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC. | Monoamine Oxidase Inhibitor (Code: N0000175744) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | 1961-06-09 FDA | |
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| betahistine | Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) None (Source: CHEMBL) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) inverse agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20530654) | A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. | H1-receptor agonist (Code: CHEBI:71173) vasodilator agent (Code: CHEBI:35620) Cardiovascular Agents (Code: D002317) Histamine Agents (Code: D018494) Histamine Agonists (Code: D017442) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | |
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| isopromethazine | None | |
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| homonicotinic acid | Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) None (Source: IUPHAR) | None | |
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| bethanechol | Muscarinic acetylcholine receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8VH26, gene: GPM3, swissprot: Q8VH26_CAVPO) None (Source: CHEMBL) Muscarinic receptor 2 (Organism: Cavia porcellus, class: Unclassified, accessions: Q8VH27, gene: GPM2, swissprot: Q8VH27_CAVPO) None (Source: CHEMBL) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) agonist (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: IUPHAR) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) agonist (Source: IUPHAR) | A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM. | muscarinic agonist (Code: CHEBI:38325) Cholinergic Muscarinic Agonist (Code: N0000175840) Cholinergic Muscarinic Agonists (Code: N0000000104) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 1948-10-12 FDA | |
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| methyl nicotinate | erythema provoked is basis of a methylnicotinate test of anti-inflammatories | None FDA | |
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| salicylamide | It blocks cyclooxygenase, breaks the metabolism of arachidonic acid, reduces the amount of prostaglandins both in the inflammation focus and in healthy tissues, suppresses the exudative and proliferative phase of inflammation. Reduces the permeability of capillaries; stabilizes the lysosomal membranes; inhibits the production of macroergers (primarily ATP) in the processes of oxidative phosphorylation; inhibits synthesis or inactivates mediators of inflammation, incl. histamine, bradykinin, lymphokines, complement factor and other nonspecific endogenous "damaging factors". It blocks the interaction of bradykinin with tissue receptors, restores disturbed microcirculation and reduces pain sensitivity in the inflammatory focus | non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1964-04-30 Ministry of Health of the Russian Federation | 4K17 |
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| aminobenzoic acid | Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Dihydropteroate synthase (Organism: Bacillus anthracis, class: Enzyme, accessions: Q81VW8, gene: folP, swissprot: Q81VW8_BACAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) | An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS. | Vitamin B Complex Compounds (Code: N0000175715) Vitamin B Complex Member (Code: N0000175714) | 2006-07-28 Ministry of Health of the Russian Federation | 1IUS 1IUT 1IUU 1PBD 2DZA 3Q2A 3TYZ 5UUR |
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| isoniazid | Catalase-peroxidase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WIE4, gene: katG, swissprot: KATG_MYCTO) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGR1, gene: inhA, swissprot: INHA_MYCTU) inhibitor (Source: CHEMBL) Dihydrofolate reductase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WNX1, gene: folA, swissprot: DYR_MYCTU) None (Source: CHEMBL) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) | Antibacterial agent used primarily as a tuberculostatic, inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. It remains the treatment of choice for tuberculosis | drug allergen (Code: CHEBI:88188) antitubercular agent (Code: CHEBI:33231) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antitubercular Agents (Code: D000995) Fatty Acid Synthesis Inhibitors (Code: D054872) Hypolipidemic Agents (Code: D000960) | 1952-09-29 FDA | 3WXO 4PAE 5KSG 5KSN 5KT8 5SXQ 5SXS 5SXT 5SYI 5SYJ 6CDQ 6CFQ |
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| dimetofrine | proposed cardiovascular stimulant; minor descriptor (75-85); on-line & Index Medicus search ETHANOLAMINES (75-85); RN given refers to parent cpd without isomeric designation | |
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| pralidoxime | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) activator (Source: CHEMBL) | The principal ation of pralidoxime is to reactivate cholinesterase (mainly outside the central nervous system) which has been inactivated by phosphorylation due to an organophosphorus nerve agent or related compound | cholinergic drug (Code: CHEBI:38323) antidote to organophosphate poisoning (Code: CHEBI:90753) antidote to sarin poisoning (Code: CHEBI:136860) Cholinesterase Reactivator (Code: N0000175742) Antidotes (Code: D000931) Cholinergic Agents (Code: D018678) Cholinesterase Reactivators (Code: D002801) Enzyme Reactivators (Code: D004793) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1964-03-11 FDA | |
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| phenylethanolamine | None | |
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| tyramine | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) None (Source: CHEMBL) TyR1 (Organism: Chilo suppressalis, class: GPCR, accessions: H9TVJ1, gene: None, swissprot: H9TVJ1_9NEOP) None (Source: CHEMBL) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: CHEMBL) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21073468) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) agonist (Source: IUPHAR) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) agonist (Source: IUPHAR) | An indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems. | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Autonomic Agents (Code: D001337) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 3BRA 4N7C 5FF9 |
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| isaxonine | promotes nerve growth | |
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| fosfomycin | UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (Organism: Enterococcus faecalis (strain ATCC 700802 / V583), class: Enzyme, accessions: Q836E5, gene: murA1, swissprot: MURA1_ENTFA) UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (Organism: Enterococcus faecalis (strain ATCC 700802 / V583), class: Enzyme, accessions: Q831A8, gene: murA2, swissprot: MURA2_ENTFA) UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A749, gene: murA, swissprot: MURA_ECOLI) inhibitor (Source: CHEMBL) UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Unclassified, accessions: Q9HVW7, gene: murA, swissprot: MURA_PSEAE) None (Source: CHEMBL) | An antibiotic produced by Streptomyces fradiae. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1996-12-19 FDA | 1LQP 2BNN 3D41 3QUO 4IR0 4JD1 4JH3 4JH4 4JH5 4JH6 4JH8 5V3D |
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| salicylic acid | Salicylic acid-binding protein 2 (Organism: Nicotiana tabacum, class: Enzyme, accessions: Q6RYA0, gene: SABP2, swissprot: SABP2_TOBAC) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: CHEMBL) Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) | A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions. | antiinfective agent (Code: CHEBI:35441) keratolytic drug (Code: CHEBI:50176) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antifungal Agents (Code: D000935) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Dermatologic Agents (Code: D003879) Enzyme Inhibitors (Code: D004791) Keratolytic Agents (Code: D007641) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1898-01-01 YEAR INTRODUCED | 1FIQ 1FO4 1JGS 1M6E 1PTH 1WYG 1Y7I 2E1Q 2FN1 2I2Z 2I30 2Y7K 2Y7P 2Y7W 3AX7 3AX9 3B9M 3BPX 3DEU 3GF2 3HGX 3KP6 3N8Y 3NJZ 3NVC 3REM 3RET 3TWP 3UNA 3UNC 3UNI 3W1W 3ZMD 4EM0 4EM2 4EQ4 4EQL 4HVR 4L39 4Y03 5EVY 5F1A 5M78 5OF1 5SWR 5U6M 5U6N 5X80 |
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| phenoxyethanol | None | antiinfective agent (Code: CHEBI:35441) central nervous system depressant (Code: CHEBI:35488) Anesthetics (Code: D000777) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | None FDA | 2RBR |
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| pentetrazol | A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility. | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) GABA Agents (Code: D018682) GABA Antagonists (Code: D018756) Neurotransmitter Agents (Code: D018377) | 2015-11-11 EMA | |
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| methazolamide | Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) None (Source: CHEMBL) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Homo sapiens, class: Enzyme, accessions: O43570|P00915|P00918|P07451|P22748|P23280|P35218|P43166|Q16790|Q8N1Q1|Q9ULX7|Q9Y2D0, gene: CA1|CA12|CA13|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA9, swissprot: CAH12_HUMAN|CAH13_HUMAN|CAH14_HUMAN|CAH1_HUMAN|CAH2_HUMAN|CAH3_HUMAN|CAH4_HUMAN|CAH5A_HUMAN|CAH5B_HUMAN|CAH6_HUMAN|CAH7_HUMAN|CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) inhibitor (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) inhibitor (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) None (Source: CHEMBL) Carbonic anhydrase V (Organism: Homo sapiens, class: Enzyme, accessions: P35218|Q9Y2D0, gene: CA5A|CA5B, swissprot: CAH5A_HUMAN|CAH5B_HUMAN) None (Source: CHEMBL) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) inhibitor (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) inhibitor (Source: CHEMBL) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) None (Source: CHEMBL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) None (Source: CHEMBL) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) None (Source: CHEMBL) | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Carbonic Anhydrase Inhibitors (Code: D002257) Diuretics (Code: D004232) Enzyme Inhibitors (Code: D004791) Natriuretic Agents (Code: D045283) | 1959-01-26 FDA | 1BZM 3DAZ 3DCS 4K0Z 4YHA 5C8I 5KU6 |
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| irofulven | Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) | None | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) Radiation-Sensitizing Agents (Code: D011838) | |
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| methenamine | An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173) | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | 1967-07-05 FDA | |
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| furtrethonium | None | Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Neurotransmitter Agents (Code: D018377) | |
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| ethosuximide | Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) blocker (Source: CHEMBL) | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. | anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1960-11-02 FDA | |
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| isometheptene | None | None FDA | |
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| cyclopentamine | None | |
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| metyrapone | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (Source: DRUG MATRIX) Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012911Orig1s033lbl.pdf) Cytochrome P450 11B1 (Organism: Bos taurus, class: Unclassified, accessions: P15150, gene: CYP11B1, swissprot: C11B1_BOVIN) None (Source: CHEMBL) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN)) None (Source: CHEMBL) Cytochrome P450 11B1, mitochondrial (Organism: Rattus norvegicus, class: Unclassified, accessions: P15393, gene: Cyp11b1, swissprot: C11B1_RAT)) None (Source: CHEMBL) | An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. | diagnostic agent (Code: CHEBI:33295) Adrenal Steroid Synthesis Inhibitor (Code: N0000175928) Adrenal Steroid Synthesis Inhibitors (Code: N0000175921) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) | 1961-12-04 FDA | 1PHG 1W0G 4ZF8 |
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| kojic acid | D-amino-acid oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P14920, gene: DAO, swissprot: OXDA_HUMAN) None (Source: CHEMBL) D-amino-acid oxidase (Organism: Sus scrofa, class: Unclassified, accessions: P00371, gene: DAO, swissprot: OXDA_PIG) None (Source: CHEMBL) Tyrosinase (Organism: Mus musculus, class: Unclassified, accessions: P11344, gene: Tyr, swissprot: TYRO_MOUSE) None (Source: CHEMBL) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: CHEMBL) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) None (Source: CHEMBL) | None | skin lightening agent (Code: CHEBI:85046) Antioxidants (Code: D000975) Protective Agents (Code: D020011) | 1GQH 3NQ1 5I38 5M8M 5M8Q |
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| piracetam | A compound suggested to be both a nootropic and a neuroprotective agent. | Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Nootropic Agents (Code: D018697) Protective Agents (Code: D020011) | 1972-01-01 YEAR INTRODUCED | 3LSF 3LSL 3LSX |
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| methylthiouracil | A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism. | Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| mesna | A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE. The first step in the detoxification process is the binding of mesna to 4-hydroxyifosfamide forming a non-urotoxic 4-sulfoethylthioifosfamide. Mesna also binds to the double bonds of acrolein and to other urotoxic metabolites and inhibits their effects on the bladder | Protective Agents (Code: D020011) | 1988-12-30 FDA | |
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| trimethadione | Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) blocker (Source: CHEMBL) | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1946-01-25 FDA | |
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| valpromide | None | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1NU3 2CJP 3G0I 5AIG |
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| valnoctamide | None | |
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| betanaphthol | None | antinematodal drug (Code: CHEBI:35444) | 3U3K 4B32 |
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| trichloroacetic acid | A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts. | Caustics (Code: D002424) Noxae (Code: D009676) | None FDA | |
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| octanoic acid | None | 1H2B 1U8U 1V2G 2BUI 2EUM 2QHS 2WG9 3L91 3NQ9 3WL8 4RW3 4RW5 5EFI 5F2K 5KP2 5TID 5TIE 5TIF 5X52 |
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| valproic acid | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) None (source: CHEMBL) Alcohol dehydrogenase [NADP(+)] (Organism: Homo sapiens, class: Enzyme, accessions: P14550, gene: AKR1A1, swissprot: AK1A1_HUMAN) None (source: CHEMBL) Alcohol dehydrogenase [NADP(+)] (Organism: Sus scrofa, class: Enzyme, accessions: P50578, gene: AKR1A1, swissprot: AK1A1_PIG) None (source: CHEMBL) Alcohol dehydrogenase [NADP(+)] (Organism: Rattus norvegicus, class: Enzyme, accessions: P51635, gene: Akr1a1, swissprot: AK1A1_RAT) None (source: CHEMBL) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) None (source: CHEMBL) Succinate-semialdehyde dehydrogenase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P51649, gene: ALDH5A1, swissprot: SSDH_HUMAN) inhibitor (source: CHEMBL) UDP-glucuronosyltransferase 1-5 (Organism: Homo sapiens, class: Enzyme, accessions: P35504, gene: UGT1A5, swissprot: UD15_HUMAN) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) inhibitor (source: IUPHAR) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) None (source: CHEMBL) Aldose reductase-related protein 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q5RJP0, gene: Akr1b7, swissprot: ALD1_RAT) None (source: CHEMBL) | A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels. | GABA agent (Code: CHEBI:51374) anticonvulsant (Code: CHEBI:35623) psychotropic drug (Code: CHEBI:35471) neuroprotective agent (Code: CHEBI:63726) antimanic drug (Code: CHEBI:35477) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Mood Stabilizer (Code: N0000175751) Anticonvulsants (Code: D000927) Antimanic Agents (Code: D018692) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Enzyme Inhibitors (Code: D004791) GABA Agents (Code: D018682) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1978-02-28 FDA | 1DIT |
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| octamoxin | None | |
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| ethchlorvynol | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive modulator (source: CHEMBL) | A sedative and hypnotic that has been used in the short-term management of INSOMNIA. Its use has been superseded by other drugs. | sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1961-05-10 FDA | |
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| methyl aminolevulinate | None | antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) prodrug (Code: CHEBI:50266) dermatologic drug (Code: CHEBI:50177) Porphyrin Precursor (Code: N0000175846) Porphyrinogens (Code: N0000171207) | 2004-07-27 FDA | |
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| oxyquinoline | 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) None (Source: CHEMBL) Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) None (Source: CHEMBL) Methionine aminopeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P53582, gene: METAP1, swissprot: MAP11_HUMAN) None (Source: CHEMBL) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: CHEMBL) Bacterial leucyl aminopeptidase (Organism: Vibrio proteolyticus, class: Enzyme, accessions: Q01693, gene: None, swissprot: AMPX_VIBPR) None (Source: CHEMBL) | An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics. | antiseptic drug (Code: CHEBI:48218) antifungal agrochemical (Code: CHEBI:86328) | 1985-12-24 FDA | 3KCY 3VH9 4JFG |
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| emylcamate | |
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| heptaminol | An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism. | |
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| trioxsalen | Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) None (Source: DRUG MATRIX) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) (Source: DRUG MATRIX) | Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo. | dermatologic drug (Code: CHEBI:50177) photosensitizing agent (Code: CHEBI:47868) Psoralen (Code: N0000175879) Psoralens (Code: N0000007909) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) | 1964-07-24 FDA | |
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| gimeracil | Dihydropyrimidine dehydrogenase [NADP(+)] (Organism: Homo sapiens, class: Enzyme, accessions: Q12882, gene: DPYD, swissprot: DPYD_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21668582) | a biochemical and pharmacological modulator of 5-FU | 2011-03-14 EMA | |
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| adipic acid | Solute carrier family 22 member 6 (Organism: Mus musculus, class: Transporter, accessions: Q8VC69, gene: Slc22a6, swissprot: S22A6_MOUSE) None (Source: CHEMBL) | None | food acidity regulator (Code: CHEBI:64049) | 4DHW 4JT0 4UTZ 5D2J 5OKU |
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| isosorbide | 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma. | Diuretics (Code: D004232) Diuretics, Osmotic (Code: D004234) Natriuretic Agents (Code: D045283) | 1974-01-30 FDA | |
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| coumarin | Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) | effective in reducing edema following crush & thermal injury; structure in Merck Index, 9th ed, #2547; Coumarin itself occurs in the Tonka bean | fluorescent dye (Code: CHEBI:51121) | 1Z10 2H90 2PMJ 2PWB 3CRB 3L5M 3L66 3L68 4UTI 4UTL |
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| glutamine | A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. | Amino Acid (Code: N0000175780) Amino Acids (Code: N0000006806) | 2004-06-10 FDA | |
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| acetylpheneturide | None | |
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| lysine | Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) None (Source: CHEMBL) | An essential amino acid. It is often added to animal feed. | nutraceutical (Code: CHEBI:50733) anticonvulsant (Code: CHEBI:35623) | None FDA | |
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| oxapropanium | None | |
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| acetylcholine | Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: CHEMBL) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: CHEMBL) Nicotinic acetylcholine receptor alpha8 subunit (Organism: Periplaneta americana, class: Unclassified, accessions: H6TY12, gene: None, swissprot: H6TY12_PERAM) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) None (Source: CHEMBL) Acetylcholine-binding protein (Organism: Lymnaea stagnalis, class: Unclassified, accessions: P58154, gene: None, swissprot: ACHP_LYMST) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: IUPHAR) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: IUPHAR) | A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. | vasodilator agent (Code: CHEBI:35620) muscarinic agonist (Code: CHEBI:38325) Cholinergic Receptor Agonist (Code: N0000175884) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 1973-10-09 FDA | 2ACE 2HA4 2J0H 2RIN 2XZ5 3Q5S 3RQW 3WIP |
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| trientine | copper (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.ncbi.nlm.nih.gov/pubmed/6121964) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) | An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION. | Metal Chelating Activity (Code: N0000175472) Metal Chelator (Code: N0000175473) Chelating Agents (Code: D002614) Sequestering Agents (Code: D064449) | 1985-11-08 FDA | 1DJ6 |
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| ambazone | Bacteriostatic action on hemolytic streptococcus, Streptococcus pneumoniae and viridans streptococci. | 2010-05-17 Ministry of Health of the Russian Federation | |
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| glutamic acid | Metabotropic glutamate receptor 8 (Organism: Homo sapiens, class: GPCR, accessions: O00222, gene: GRM8, swissprot: GRM8_HUMAN) None (Source: IUPHAR) Metabotropic glutamate receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: Q14832, gene: GRM3, swissprot: GRM3_HUMAN) None (Source: IUPHAR) Glutamate dehydrogenase 2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P49448, gene: GLUD2, swissprot: DHE4_HUMAN) Glutamate dehydrogenase 1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00367, gene: GLUD1, swissprot: DHE3_HUMAN) Glutamate receptor ionotropic, kainate 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q16099, gene: GRIK4, swissprot: GRIK4_HUMAN) None (Source: PDSP) Glutamate receptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P42263, gene: GRIA3, swissprot: GRIA3_HUMAN) None (Source: PDSP) Metabotropic glutamate receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: Q14831, gene: GRM7, swissprot: GRM7_HUMAN) Excitatory amino acid transporter 3 (Organism: Homo sapiens, class: Transporter, accessions: P43005, gene: SLC1A1, swissprot: EAA3_HUMAN) None (Source: CHEMBL) Metabotropic glutamate receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q13255, gene: GRM1, swissprot: GRM1_HUMAN) None (Source: CHEMBL) Metabotropic glutamate receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q14416, gene: GRM2, swissprot: GRM2_HUMAN) None (Source: CHEMBL) Metabotropic glutamate receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P41594, gene: GRM5, swissprot: GRM5_HUMAN) None (Source: CHEMBL) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: CHEMBL) Metabotropic glutamate receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q14833, gene: GRM4, swissprot: GRM4_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 1 (Organism: Homo sapiens, class: Ion channel, accessions: P39086, gene: GRIK1, swissprot: GRIK1_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q16478, gene: GRIK5, swissprot: GRIK5_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q13003, gene: GRIK3, swissprot: GRIK3_HUMAN) None (Source: CHEMBL) Glutamate receptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: P48058, gene: GRIA4, swissprot: GRIA4_HUMAN) None (Source: CHEMBL) Glutamate receptor 2 (Organism: Homo sapiens, class: Ion channel, accessions: P42262, gene: GRIA2, swissprot: GRIA2_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q13002, gene: GRIK2, swissprot: GRIK2_HUMAN) None (Source: CHEMBL) Glutamate receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P42261, gene: GRIA1, swissprot: GRIA1_HUMAN) None (Source: CHEMBL) Metabotropic glutamate receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: O15303, gene: GRM6, swissprot: GRM6_HUMAN) None (Source: CHEMBL) Excitatory amino acid transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P43003, gene: SLC1A3, swissprot: EAA1_HUMAN) None (Source: CHEMBL) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) None (Source: CHEMBL) Excitatory amino acid transporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P43004, gene: SLC1A2, swissprot: EAA2_HUMAN) None (Source: CHEMBL) Glutamate receptor 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19490, gene: Gria1, swissprot: GRIA1_RAT) None (Source: CHEMBL) Glutamate receptor 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19491, gene: Gria2, swissprot: GRIA2_RAT) None (Source: CHEMBL) Glutamate receptor 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19492, gene: Gria3, swissprot: GRIA3_RAT) None (Source: CHEMBL) Glutamate receptor 4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19493, gene: Gria4, swissprot: GRIA4_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P22756, gene: Grik1, swissprot: GRIK1_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: P23385, gene: Grm1, swissprot: GRM1_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31421, gene: Grm2, swissprot: GRM2_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31422, gene: Grm3, swissprot: GRM3_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: P31423, gene: Grm4, swissprot: GRM4_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 5 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31424, gene: Grm5, swissprot: GRM5_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P35349, gene: Grm6, swissprot: GRM6_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P42260, gene: Grik2, swissprot: GRIK2_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P42264, gene: Grik3, swissprot: GRIK3_RAT) None (Source: CHEMBL) Metabotropic glutamate receptor 8 (Organism: Mus musculus, class: Unclassified, accessions: P47743, gene: Grm8, swissprot: GRM8_MOUSE) None (Source: CHEMBL) Metabotropic glutamate receptor 8 (Organism: Rattus norvegicus, class: Unclassified, accessions: P70579, gene: Grm8, swissprot: GRM8_RAT) None (Source: CHEMBL) Glutamate racemase (Organism: Lactobacillus fermentum, class: Unclassified, accessions: Q03469, gene: murI, swissprot: MURI_LACFE) None (Source: CHEMBL) | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. | 1985 FDA | |
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| meldonium | Gamma-butyrobetaine dioxygenase (Organism: Homo sapiens, class: Enzyme, accessions: O75936, gene: BBOX1, swissprot: BODG_HUMAN) None (Source: CHEMBL) | structural analog of gamma-butyrobetaine, also of carnitine; antianginal compound; MET-88 is dihydrate; structure given in first source | cardioprotective agent (Code: CHEBI:77307) neuroprotective agent (Code: CHEBI:63726) | 2006 Ministry of Health of the Russian Federation | |
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| carbachol | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) None (Source: CHEMBL) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8VH26, gene: GPM3, swissprot: Q8VH26_CAVPO) None (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Rattus norvegicus, class: GPCR, accessions: P08485, gene: Chrm4, swissprot: ACM4_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Mus musculus, class: GPCR, accessions: Q9ERZ4, gene: Chrm2, swissprot: ACM2_MOUSE) None (Source: CHEMBL) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Mus musculus, class: GPCR, accessions: P12657, gene: Chrm1, swissprot: ACM1_MOUSE) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS. | nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) muscarinic agonist (Code: CHEBI:38325) cardiotonic drug (Code: CHEBI:38147) miotic (Code: CHEBI:51068) non-narcotic analgesic (Code: CHEBI:35481) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Miotics (Code: D008916) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sensory System Agents (Code: D018689) | 1972-09-28 FDA | 1UV6 |
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| ketoxal | modifies guanine containing oligoribonucleotides by reacting selectively with guanine in polynucleotides; structure | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | |
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| viloxazine | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: CHEMBL) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) None (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: KEGG DRUG) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: CHEMBL) | A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE. | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | |
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| trolamine | None | 1958 FDA | 2HMP 3FRL 3H7C 3RQ0 3ZUK 5CIX |
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| methionine | S-ribosylhomocysteine lyase (Organism: Bacillus subtilis (strain 168), class: Unclassified, accessions: O34667, gene: luxS, swissprot: LUXS_BACSU) None (Source: CHEMBL) | A sulfur-containing essential L-amino acid that is important in many body functions. | 1975 FDA | |
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| penicillamine | copper (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/19853s012,014lbl.pdf) Succinyl-diaminopimelate desuccinylase (Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), class: Enzyme, accessions: P44514, gene: dapE, swissprot: DAPE_HAEIN) None (Source: CHEMBL) | 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease. | antirheumatic drug (Code: CHEBI:35842) Antirheumatic Agent (Code: N0000175713) Antidotes (Code: D000931) Antirheumatic Agents (Code: D018501) Chelating Agents (Code: D002614) Protective Agents (Code: D020011) Sequestering Agents (Code: D064449) | 1970-12-04 FDA | 3H5G |
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| phenpromethamine | None | |
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| tioxolone | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) | antiseborrheic agent | antiseborrheic (Code: CHEBI:59010) | |
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| phentermine | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) | A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity. | dopaminergic agent (Code: CHEBI:48560) adrenergic agent (Code: CHEBI:37962) sympathomimetic agent (Code: CHEBI:35524) appetite depressant (Code: CHEBI:50507) central nervous system drug (Code: CHEBI:35470) central nervous system stimulant (Code: CHEBI:35337) Appetite Suppression (Code: N0000175372) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic Amine Anorectic (Code: N0000175423) Adrenergic Agents (Code: D018663) Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1959-05-04 FDA | |
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| isocarboxazid | Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: CHEMBL) | An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311) | Monoamine Oxidase Inhibitor (Code: N0000175744) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | 1959-07-01 FDA | |
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| methamphetamine | Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) None (Source: CHEMBL) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (Source: CHEMBL) Synaptic vesicular amine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q01827, gene: Slc18a2, swissprot: VMAT2_RAT) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: CHEMBL) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: PDSP) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: PDSP) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: PDSP) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: PDSP) | A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed. | psychotropic drug (Code: CHEBI:35471) central nervous system stimulant (Code: CHEBI:35337) Amphetamine Anorectic (Code: N0000175425) Amphetamines (Code: N0000007883) Appetite Suppression (Code: N0000175372) Central Nervous System Stimulation (Code: N0000175729) Increased Sympathetic Activity (Code: N0000175651) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1943-12-31 FDA | 3GKZ 4GQP 4XP6 |
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| ditiocarb | Carbonic anhydrase 1; GH09688p (Organism: Drosophila melanogaster, class: Enzyme, accessions: Q9V396, gene: CAH1, swissprot: Q9V396_DROME) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2, isoform A; LD26647p (Organism: Drosophila melanogaster, class: Enzyme, accessions: Q9VTU8, gene: CAH2, swissprot: Q9VTU8_DROME) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) | A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM. | Adjuvants, Immunologic (Code: D000276) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Chelating Agents (Code: D002614) Immunologic Factors (Code: D007155) Sequestering Agents (Code: D064449) | |
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| tartaric acid | None | 1985-08-07 FDA | 5UC7 |
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| moroxydine | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | |
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| xylose | None | 1987-03-26 FDA | |
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| levofacetoperane | None | |
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| cresatin | None | |
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| paroxypropione | None | |
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| pheniprazine | Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17404836) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17404836) | Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. It was also used in the treatment of angina pectoris and schizophrenia. Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis. | |
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| ethylmethylthiambutene | None | |
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| paracetamol | Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Arachidonate 5-lipoxygenase-activating protein (Organism: Homo sapiens, class: Cytosolic other, accessions: P20292, gene: ALOX5AP, swissprot: AL5AP_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Myoglobin (Organism: Homo sapiens, class: Unclassified, accessions: P02144, gene: MB, swissprot: MYG_HUMAN) None (Source: CHEMBL) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/23940628) Transient receptor potential cation channel subfamily V member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NER1, gene: TRPV1, swissprot: TRPV1_HUMAN) opener (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: CHEMBL) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) | Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. | non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Antipyretics (Code: D058633) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1968-11-07 FDA | 1TYL 1TYM 2DPZ 2OCU 3PY4 4A9J 4A9K 4CUT 4GN6 4YJI 5PBE |
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| aminomethylbenzoic acid | an antifibrinolytic | Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Protease Inhibitors (Code: D011480) | 1983-08-04 Ministry of Health of the Russian Federation | |
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| phenicarbazide | None | |
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| cathine | major metabolite of diethylpropion in man under acidic urine conditions; RN given refers to cpd without isomeric designation | Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Central Nervous System Agents (Code: D002491) | |
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| phenylpropanolamine | Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) None (Source: CHEMBL) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) None (Source: CHEMBL) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) None (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: PDSP) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) None (Source: PDSP) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) None (Source: CHEMBL) | A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 2000-09-29 FDA | 3U8Q |
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| hydroxyamfetamine | Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22037049) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: CHEMBL) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) None (Source: CHEMBL) | Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine. | Adrenergic Agonists (Code: N0000000122) Adrenergic Receptor Agonist (Code: N0000175883) | 1969-07-16 FDA | 3BUF |
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| gepefrine | isomer of PARA-HYDROXYAMPHETAMINE which is also called alpha-methyl-tyramine | |
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| amantadine | Matrix protein 2 (Organism: Influenza A virus (A/udorn/1972(H3N2)), class: Unclassified, accessions: Q20MD5, gene: M2, swissprot: Q20MD5_9INFA) None (Source: CHEMBL) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (Source: CHEMBL) Matrix protein 2 (Organism: Influenza A virus (strain A/Udorn/307/1972 H3N2), class: Ion channel, accessions: P63231, gene: M, swissprot: M2_I72A2) inhibitor (Source: CHEMBL) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) None (Source: CHEMBL) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) blocker (Source: CHEMBL) | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. | antiviral drug (Code: CHEBI:36044) antiparkinson drug (Code: CHEBI:48407) dopaminergic agent (Code: CHEBI:48560) analgesic (Code: CHEBI:35480) non-narcotic analgesic (Code: CHEBI:35481) Influenza A M2 Protein Inhibitor (Code: N0000175543) M2 Protein Inhibitors (Code: N0000175542) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Dyskinesia Agents (Code: D018726) Anti-Infective Agents (Code: D000890) Antiparkinson Agents (Code: D000978) Antiviral Agents (Code: D000998) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1968-02-14 FDA | 3C9J 3UIV |
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| methylparaben | Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) | used as a preservative in cosmetics but potentiates UV-induced damage of skin; RN given refers to parent cpd | antimicrobial food preservative (Code: CHEBI:65256) neuroprotective agent (Code: CHEBI:63726) Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Pharmaceutic Aids (Code: D010592) Preservatives, Pharmaceutical (Code: D011310) | 2VK0 3MTH |
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| mandelic acid | Dermatologic | 1MCZ 1MDL 3TTE 3ZGJ 4P56 |
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| hydroxymethylnicotinamide | the amide derivative of nicotinic acid and formaldehyde. Has a choleretic (choleretic) effect, and also promotes the secretion of bile (cholekinetic effect). In addition, it has a bacteriostatic and bactericidal action, which is due to the fact that during the metabolism, the formaldehyde part of the drug molecule is cleaved. The other part of the molecule (nicotinamide) has the properties of vitamin PP, increases the secretory function of the liver parenchyma, enhancing the secretion of bile and facilitating its entry into the intestine. The drug is used in complex treatment violations of the liver, with cholecystitis, as well as infections of the urinary tract and gastroenteritis. It is effective in the treatment of infections caused by E. coli. | 1964-04-30 Ministry of Health of the Russian Federation | |
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| tisopurine | 4-thio analog of allopurinol; structure | Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) | |
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| debrisoquine | Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) | An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. | antihypertensive agent (Code: CHEBI:35674) adrenergic agent (Code: CHEBI:37962) sympatholytic agent (Code: CHEBI:66991) Adrenergic Agents (Code: D018663) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1965-01-01 YEAR INTRODUCED | |
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| mercaptopurine | Purine nucleoside phosphorylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WP01, gene: punA, swissprot: PUNA_MYCTU) None (Source: CHEMBL) Amidophosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q06203, gene: PPAT, swissprot: PUR1_HUMAN) inhibitor (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Thiopurine S-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P51580, gene: TPMT, swissprot: TPMT_HUMAN) Purine nucleoside phosphorylase (Organism: Homo sapiens, class: Enzyme, accessions: P00491, gene: PNP, swissprot: PNPH_HUMAN) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1953-09-11 FDA | |
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| homocamfin | None | |
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| camphor | Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: CHEMBL) Transient receptor potential cation channel subfamily A member 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BLA8, gene: Trpa1, swissprot: TRPA1_MOUSE) negative modulator (Source: IUPHAR) | A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | 1970-11-12 Ministry of Health of the Russian Federation | |
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| aminosalicylic acid | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Kinase, accessions: P9WNC6, gene: folK, swissprot: HPPK_MYCTO) Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) None (Source: CHEMBL) Cyclooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P23219|P35354, gene: PTGS1|PTGS2, swissprot: PGH1_HUMAN|PGH2_HUMAN) inhibitor (Source: CHEMBL) | An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid. | antitubercular agent (Code: CHEBI:33231) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) | 1982-01-01 FDA | 1PBC 1PBF 1SXK 5X7Z |
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| mesalazine | Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) inhibitor (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: CHEMBL) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) agonist (Source: IUPHAR) | An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed) | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Aminosalicylate (Code: N0000175781) Aminosalicylic Acids (Code: N0000005760) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1987-12-24 FDA | |
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| octopamine | TyR1 (Organism: Chilo suppressalis, class: GPCR, accessions: H9TVJ1, gene: None, swissprot: H9TVJ1_9NEOP) None (Source: CHEMBL) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) None (Source: CHEMBL) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: IUPHAR) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) agonist (Source: IUPHAR) | An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasoconstrictor Agents (Code: D014662) | 1RG1 1RG2 1RGT 1RGU 1RH0 2AN4 3HCA 3HCE 4QJQ |
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| enbucrilate | A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental. | |
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| norfenefrine | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Neurotransmitter Agents (Code: D018377) | |
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| dopamine | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) agonist (Source: WOMBAT-PK) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) None (Source: CHEMBL) D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: CHEMBL) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: CHEMBL) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) None (Source: CHEMBL) Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) None (Source: CHEMBL) Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: CHEMBL) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) None (Source: CHEMBL) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) None (Source: CHEMBL) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) None (Source: CHEMBL) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) None (Source: CHEMBL) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: CHEMBL) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) agonist (Source: WOMBAT-PK) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) Dopamine beta-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: P09172, gene: DBH, swissprot: DOPO_HUMAN) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) None (Source: CHEMBL) Lysine-specific demethylase 4E (Organism: Homo sapiens, class: Enzyme, accessions: B2RXH2, gene: KDM4E, swissprot: KDM4E_HUMAN) None (Source: CHEMBL) Adenosine A2b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276, gene: Adora2b, swissprot: AA2BR_RAT) None (Source: CHEMBL) M18 aspartyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8I2J3, gene: None, swissprot: Q8I2J3_PLAF7) None (Source: CHEMBL) | One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. | cardiotonic drug (Code: CHEBI:38147) beta-adrenergic agonist (Code: CHEBI:35522) dopaminergic agent (Code: CHEBI:48560) sympathomimetic agent (Code: CHEBI:35524) Catecholamine (Code: N0000175570) Catecholamines (Code: N0000007715) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Dopamine Agents (Code: D015259) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sympathomimetics (Code: D013566) | 1974-02-25 FDA | 2A3R 2QMZ 2VQ5 3NK2 4A7V 4DTZ 4DU2 4DUB 4XP1 5LOG 5PAH 5PHH |
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| gentisic acid | Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) | None | MALDI matrix material (Code: CHEBI:64345) | 3JUT 3NL1 3NW4 4E3D 4FAG |
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| acipimox | Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/17705685) | lipolysis inhibitor, only to be used as additional or alternative treatment to reduce high triglyceride levels | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 2014-03-13 EMA | |
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| guancidine | |
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| allomethadione | None | |
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| chlorphenesin carbamate | A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203) | muscle relaxant (Code: CHEBI:51371) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | 1965-06-14 FDA | |
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| histidine | An essential amino acid that is required for the production of HISTAMINE. | 1975 FDA | |
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| bemegride | A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose. | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) Respiratory System Agents (Code: D019141) | None Ministry of Health of the Russian Federation | |
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| valdetamide | Sedative | |
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| propylhexedrine | None | |
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| pempidine | A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs. | Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | |
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| bucolome | None | |
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| mechlorethamine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) None (Source: CHEMBL) | A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Chemical Warfare Agents (Code: D002619) Irritants (Code: D007509) Noxae (Code: D009676) Poisons (Code: D011042) | 1949-03-15 FDA | |
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| orotic acid | An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE. | 1968-04-30 Ministry of Health of the Russian Federation | |
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| nifuroxime | topical anti-infective agent used in protozoal & fungal infections; proposed as a radiosensitizing agent with solid tumors | |
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| diethadione | None | |
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| ectylurea | None | 1956 YEAR INTRODUCED | |
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| iprazochrome | used in prophylaxis of migraine | Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | |
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| levomenthol | Transient receptor potential cation channel subfamily M member 8 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z2W7, gene: TRPM8, swissprot: TRPM8_HUMAN) opener (Soyrce: http://www.ncbi.nlm.nih.gov/pubmed/15306801) Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) opener (source: IUPHAR) Transient receptor potential cation channel subfamily A member 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BLA8, gene: Trpa1, swissprot: TRPA1_MOUSE) negative modulator (Source: IUPHAR) | An alcohol produced from mint oils or prepared synthetically, has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. | antitussive (Code: CHEBI:51177) antispasmodic drug (Code: CHEBI:53784) antipruritic drug (Code: CHEBI:59683) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) | 2008 FDA | |
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| chloroxylenol | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: DRUG MATRIX) | a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood | molluscicide (Code: CHEBI:33904) antiseptic drug (Code: CHEBI:48218) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Disinfectants (Code: D004202) Schistosomicides (Code: D012556) | None FDA | |
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| oteracil | Uridine 5'-monophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P11172, gene: UMPS, swissprot: UMPS_HUMAN) | Antagonist of urate oxidase. | 2011-03-14 EMA | |
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| furamicid | None | |
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| paramethadione | Voltage-gated T-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43497|O95180|Q9P0X4, gene: CACNA1G|CACNA1H|CACNA1I, swissprot: CAC1G_HUMAN|CAC1H_HUMAN|CAC1I_HUMAN) blocker (Source: CHEMBL) | None | 1949-06-15 FDA | |
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| nitrefazole | None | |
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| ethadione | None | |
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| tranexamic acid | Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) inhibitor (Source: CHEMBL) | Antifibrinolytic hemostatic used in severe hemorrhage. | hematologic agent (Code: CHEBI:50248) antifibrinolytic drug (Code: CHEBI:48675) Antifibrinolytic Agent (Code: N0000175634) Decreased Fibrinolysis (Code: N0000175632) Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Fibrin Modulating Agents (Code: D050299) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) | 1986-12-30 FDA | 1CEB |
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| oxanamide | None | |
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| buformin | An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation. | Hypoglycemic Agents (Code: D007004) | None Ministry of Health of the Russian Federation | |
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| isovaleryl diethylamide | None | |
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| methylphenidate | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: PDSP) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: CHEMBL) | A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE. | Central Nervous System Stimulation (Code: N0000175729) adrenergic agent (Code: CHEBI:37962) adrenergic uptake inhibitor (Code: CHEBI:35640) dopamine uptake inhibitor (Code: CHEBI:51039) central nervous system stimulant (Code: CHEBI:35337) sympathomimetic agent (Code: CHEBI:35524) psychotropic drug (Code: CHEBI:35471) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 1955-12-05 FDA | |
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| oxiracetam | None | Central Nervous System Agents (Code: D002491) Nootropic Agents (Code: D018697) Psychotropic Drugs (Code: D011619) | |
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| tiliquinol | Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: CHEMBL) | None | |
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| citiolone | Hepatoprotectant | 1970 YEAR INTRODUCED | |
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| pregabalin | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Homo sapiens, class: Ion channel, accessions: P54289, gene: CACNA2D1, swissprot: CA2D1_HUMAN) modulator (Source: CHEMBL) Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit (Organism: Sus scrofa, class: Ion channel, accessions: O77773, gene: CACNA2D1, swissprot: O77773_PIG) None (Source: CHEMBL) Large neutral amino acids transporter small subunit 1 (Organism: Homo sapiens, class: Transporter, accessions: Q01650, gene: SLC7A5, swissprot: LAT1_HUMAN) Voltage-dependent calcium channel subunit alpha-2/delta-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY47, gene: CACNA2D2, swissprot: CA2D2_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/21651903) | Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues, pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) | anticonvulsant (Code: CHEBI:35623) Analgesics (Code: D000700) Anti-Anxiety Agents (Code: D014151) Anticonvulsants (Code: D000927) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) | 2004-07-06 EMA | |
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| pargyline | Aldehyde dehydrogenase, mitochondrial (Organism: Rattus norvegicus, class: Enzyme, accessions: P11884, gene: Aldh2, swissprot: ALDH2_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: CHEMBL) | A monoamine oxidase inhibitor with antihypertensive properties. | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) | 1982-01-01 FDA | |
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| methylchromone | None | |
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| hydralazine | Ryanodine receptor 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: B0LPN4, gene: Ryr2, swissprot: RYR2_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/23319593) Ryanodine receptor 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q92736, gene: RYR2, swissprot: RYR2_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/23319593) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) None (Source: CHEMBL) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: CHEMBL) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) DNA (cytosine-5)-methyltransferase 3B (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBC3, gene: DNMT3B, swissprot: DNM3B_HUMAN) DNA (cytosine-5)-methyltransferase 3A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6K1, gene: DNMT3A, swissprot: DNM3A_HUMAN) DNA (cytosine-5)-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P26358, gene: DNMT1, swissprot: DNMT1_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) | A direct-acting vasodilator that is used as an antihypertensive agent. | antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) Arteriolar Vasodilation (Code: N0000175379) Arteriolar Vasodilator (Code: N0000175564) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1953-01-15 FDA | 3LTW |
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| tolazoline | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. | alpha-adrenergic antagonist (Code: CHEBI:37890) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 1948-03-17 FDA | |
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| methacholine | Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Rattus norvegicus, class: GPCR, accessions: P08485, gene: Chrm4, swissprot: ACM4_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) agonist (Source: IUPHAR) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) agonist (Source: IUPHAR) | A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116) | muscarinic agonist (Code: CHEBI:38325) bronchoconstrictor agent (Code: CHEBI:50141) cholinergic agonist (Code: CHEBI:38324) vasodilator agent (Code: CHEBI:35620) Cholinergic Receptor Agonist (Code: N0000175884) Autonomic Agents (Code: D001337) Bronchoconstrictor Agents (Code: D016085) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Miotics (Code: D008916) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 1986-10-31 FDA | |
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| carpronium | None | |
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| clomethiazole | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors. | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neuroprotective Agents (Code: D018696) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1981-01-01 YEAR INTRODUCED | |
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| meglutol | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) None (Source: CHEMBL) | An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. | anticholesteremic drug (Code: CHEBI:35821) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 1DQ8 1DQA |
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| fenadiazole | None | |
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| aminorex | An amphetamine-like anorectic agent. It may cause pulmonary hypertension. | |
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| levocarnitine | Carnitine O-palmitoyltransferase 1, muscle isoform (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63704, gene: Cpt1b, swissprot: CPT1B_RAT) None (Source: CHEMBL) Carnitine palmitoyltransferase 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P18886, gene: Cpt2, swissprot: CPT2_RAT) None (Source: CHEMBL) Carnitine O-palmitoyltransferase 1, liver isoform (Organism: Homo sapiens, class: Enzyme, accessions: P50416, gene: CPT1A, swissprot: CPT1A_HUMAN) | A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism. | antilipemic drug (Code: CHEBI:35679) nutraceutical (Code: CHEBI:50733) nootropic agent (Code: CHEBI:66980) Carnitine (Code: N0000006688) Carnitine Analog (Code: N0000175903) | 1985-12-27 FDA | 3PPO |
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| oxydibutanol | None | |
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| nicotine | Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) agonist (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483, gene: Chrna4, swissprot: ACHA4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Mus musculus, class: Ion channel, accessions: O70174, gene: Chrna4, swissprot: ACHA4_MOUSE) None (Source: CHEMBL) Neuronal acetylcholine receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P09483|P12389|P12390|P12391|P12392|P20420|P25108|P25109|P43143|P43144|Q05941|Q9JLB5, gene: Chrna1|Chrna10|Chrna2|Chrna3|Chrna4|Chrna5|Chrna6|Chrna7|Chrna9|Chrnb1|Chrnb2|Chrnb3|Chrnb4, swissprot: ACH10_RAT|ACHA2_RAT|ACHA3_RAT|ACHA4_RAT|ACHA5_RAT|ACHA6_RAT|ACHA7_RAT|ACHA9_RAT|ACHA_RAT|ACHB2_RAT|ACHB3_RAT|ACHB4_RAT|ACHB_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-9 (Organism: Rattus norvegicus, class: Ion channel, accessions: P43144, gene: Chrna9, swissprot: ACHA9_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit beta-4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12392, gene: Chrnb4, swissprot: ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389, gene: Chrna2, swissprot: ACHA2_RAT) None (Source: CHEMBL) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12392, gene: Chrna2|Chrnb4, swissprot: ACHA2_RAT|ACHB4_RAT) None (Source: CHEMBL) Nicotinic acetylcholine receptor alpha 5 subunit (Organism: Musca domestica, class: Ion channel, accessions: A9XFY4, gene: nAChRalpha5, swissprot: A9XFY4_MUSDO) None (Source: CHEMBL) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Mus musculus, class: Ion channel, accessions: P49582, gene: Chrna7, swissprot: ACHA7_MOUSE) None (Source: CHEMBL) Acetylcholine receptor (Organism: Torpedo californica, class: Ion channel, accessions: P02710|P02712|P02714|P02718, gene: CHRNA1|CHRNB1|CHRNG|chrnd, swissprot: ACHA_TORCA|ACHB_TORCA|ACHD_TORCA|ACHG_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757, gene: Chrna3, swissprot: ACHA3_RAT) None (Source: CHEMBL) Acetylcholine receptor subunit beta-like 2 (Organism: Drosophila melanogaster, class: Ion channel, accessions: P25162, gene: nAChRbeta2, swissprot: ACH4_DROME) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: CHEMBL) Serotonin 3 (5-HT3) receptor (Organism: Homo sapiens, class: Ion channel, accessions: A5X5Y0|O95264|P46098|Q70Z44|Q8WXA8, gene: HTR3A|HTR3B|HTR3C|HTR3D|HTR3E, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN|5HT3C_HUMAN|5HT3D_HUMAN|5HT3E_HUMAN) None (Source: CHEMBL) Acetylcholine receptor subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P02708, gene: CHRNA1, swissprot: ACHA_HUMAN) None (Source: CHEMBL) Lycopene cyclase (Organism: Pantoea ananas, class: Enzyme, accessions: P21687, gene: crtY, swissprot: CRTY_PANAN) None (Source: CHEMBL) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) None (Source: CHEMBL) Soluble acetylcholine receptor (Organism: Aplysia californica, class: Unclassified, accessions: Q8WSF8, gene: None, swissprot: Q8WSF8_APLCA) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Gallus gallus, class: Ion channel, accessions: P09482, gene: CHRNA4, swissprot: ACHA4_CHICK) None (Source: CHEMBL) Acetylcholine-binding protein (Organism: Lymnaea stagnalis, class: Unclassified, accessions: P58154, gene: None, swissprot: ACHP_LYMST) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297, gene: CHRNA3|CHRNB2, swissprot: ACHA3_HUMAN|ACHB2_HUMAN) Cytochrome P450 2A6 (Organism: Homo sapiens, class: Enzyme, accessions: P11509, gene: CYP2A6, swissprot: CP2A6_HUMAN) Potassium voltage-gated channel subfamily D member 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UK17, gene: KCND3, swissprot: KCND3_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) activator (Source: IUPHAR) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|Q15822, gene: CHRNA2|CHRNB2, swissprot: ACHA2_HUMAN|ACHB2_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P32297, gene: CHRNA3, swissprot: ACHA3_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297|Q05901|Q15825, gene: CHRNA3|CHRNA6|CHRNB2|CHRNB3, swissprot: ACHA3_HUMAN|ACHA6_HUMAN|ACHB2_HUMAN|ACHB3_HUMAN) None (Source: CHEMBL) Potassium voltage-gated channel subfamily D member 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62897, gene: Kcnd3, swissprot: KCND3_RAT) blocker (Source: IUPHAR) | Items used to aid in ending a TOBACCO habit. | biomarker (Code: CHEBI:59163) immunomodulator (Code: CHEBI:50846) peripheral nervous system drug (Code: CHEBI:49110) psychotropic drug (Code: CHEBI:35471) anxiolytic drug (Code: CHEBI:35474) nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) phytogenic insecticide (Code: CHEBI:22917) Cholinergic Nicotinic Agonist (Code: N0000175706) Nicotine (Code: N0000006496) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Ganglionic Stimulants (Code: D005731) Neurotransmitter Agents (Code: D018377) Nicotinic Agonists (Code: D018722) Peripheral Nervous System Agents (Code: D018373) | 1991-11-07 FDA | 1P2Y 1P7R 1UW6 2YK1 4EJG 4EJJ 5KXI |
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| carsalam | None | |
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| tiopronin | Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) None (Source: CHEMBL) | Sulfhydryl acylated derivative of GLYCINE. | Cystine Disulfide Reduction (Code: N0000175549) N-substituted Glycines (Code: N0000011378) Reducing and Complexing Thiol (Code: N0000175898) | 1988-08-11 FDA | 5A5Z |
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| acetylcysteine | Superoxide dismutase [Mn], mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P04179, gene: SOD2, swissprot: SODM_HUMAN) Vascular endothelial growth factor A (Organism: Homo sapiens, class: Secreted, accessions: P15692, gene: VEGFA, swissprot: VEGFA_HUMAN) Cytochrome c (Organism: Homo sapiens, class: Unclassified, accessions: P99999, gene: CYCS, swissprot: CYC_HUMAN) | The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates. | antidote to paracetamol poisoning (Code: CHEBI:74529) antiinfective agent (Code: CHEBI:35441) antiviral drug (Code: CHEBI:36044) mucolytic (Code: CHEBI:77034) vulnerary (Code: CHEBI:73336) Antidote (Code: N0000175429) Antidote for Acetaminophen Overdose (Code: N0000175961) Decreased Respiratory Secretion Viscosity (Code: N0000008867) Increased Glutathione Concentration (Code: N0000175960) Reduction Activity (Code: N0000175547) Anti-Infective Agents (Code: D000890) Antioxidants (Code: D000975) Antiviral Agents (Code: D000998) Expectorants (Code: D005100) Free Radical Scavengers (Code: D016166) Respiratory System Agents (Code: D019141) | 1963-09-14 FDA | 5NN4 2J1G |
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| cloforex | carbamic ethyl ester of chlorphentermine; structure in Negwer, 5th ed, #2275 | |
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| pentorex | None | |
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| mephentermine | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: CHEMBL) | A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1951-12-29 FDA | |
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| etilamfetamine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) | None | |
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| phenylbutanoic acid | glutamine (Organism: None, class: Amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020572s016,020573s015lbl.pdf) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) None (Source: CHEMBL) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) None (Source: CHEMBL) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) None (Source: CHEMBL) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) None (Source: CHEMBL) | a pro-drug and is rapidly metabolized to phenylacetate. Phenylacetate is a metabolically-active compound that conjugates with glutamine via acetylation to form phenylacetylglutamine. | antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Antineoplastic Agents (Code: D000970) | 1996-04-30 FDA | 2AY7 3TZ2 3TZ5 5VNL 5VNM 5VNN 5YOQ |
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| fenipentol | stimulates plasma secretion & exocrine pancreatic secretion | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) | None Ministry of Health of the Russian Federation | |
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| methiosulfonium chloride | None | |
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| methoxyflurane | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive modulator (Source: CHEMBL) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) agonist (Source: CHEMBL) | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) | inhalation anaesthetic (Code: CHEBI:38870) non-narcotic analgesic (Code: CHEBI:35481) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | None FDA | |
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| atrolactamide | None | |
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| phenylalanine | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Mus musculus, class: Ion channel, accessions: O08532, gene: Cacna2d1, swissprot: CA2D1_MOUSE) None (Source: CHEMBL) Intestinal alkaline phosphatase (Organism: Bos taurus, class: Unclassified, accessions: P19111, gene: ALPI, swissprot: PPBI_BOVIN) None (Source: CHEMBL) L-type amino acid transporter 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63016, gene: Slc7a5, swissprot: LAT1_RAT) None (Source: CHEMBL) Probable G-protein coupled receptor 139 (Organism: Homo sapiens, class: Unclassified, accessions: Q6DWJ6, gene: GPR139, swissprot: GP139_HUMAN) agonist (Source: IUPHAR) | An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. | 1975 FDA | |
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| ethenzamide | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| sulfaperin | None | antibacterial drug (Code: CHEBI:36047) | |
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| benzocaine | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 7 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q01118, gene: SCN7A, swissprot: SCN7A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 8 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UQD0, gene: SCN8A, swissprot: SCN8A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 11 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UI33, gene: SCN11A, swissprot: SCNBA_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) | A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS. | antipruritic drug (Code: CHEBI:59683) topical anaesthetic (Code: CHEBI:48425) Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| pholedrine | None | Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 4LAS |
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| pseudoephedrine | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) releasing agent (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion. | sympathomimetic agent (Code: CHEBI:35524) anti-asthmatic drug (Code: CHEBI:49167) bronchodilator agent (Code: CHEBI:35523) vasoconstrictor agent (Code: CHEBI:50514) central nervous system drug (Code: CHEBI:35470) nasal decongestant (Code: CHEBI:77715) Adrenergic alpha-Agonists (Code: N0000000209) alpha-Adrenergic Agonist (Code: N0000175552) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Vasoconstrictor Agents (Code: D014662) | 1963-10-18 FDA | |
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| ephedrine | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: IUPHAR) | A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. | sympathomimetic agent (Code: CHEBI:35524) vasoconstrictor agent (Code: CHEBI:50514) nasal decongestant (Code: CHEBI:77715) Adrenergic Agents (Code: D018663) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) alpha-Adrenergic Agonist (Code: N0000175552) Adrenergic alpha-Agonists (Code: N0000000209) beta-Adrenergic Agonist (Code: N0000175555) Adrenergic beta-Agonists (Code: N0000000245) Norepinephrine Releasing Agent (Code: N0000192563) Increased Norepinephrine Activity (Code: N0000009456) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | None FDA | |
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| cycloguanil | Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium falciparum, class: Enzyme, accessions: P13922, gene: None, swissprot: DRTS_PLAFK) inhibitor (Source: CHEMBL) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) None (Source: CHEMBL) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) None (Source: CHEMBL) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) None (Source: CHEMBL) Dihydrofolate reductase (Organism: Gallus gallus, class: Enzyme, accessions: P00378, gene: DHFR, swissprot: DYR_CHICK) None (Source: CHEMBL) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) None (Source: CHEMBL) | was MH 1975-92 (see under TRIAZINES 1975-90); use CYCLOGUANIL EMBONATE was see CYCLOGUANIL PAMOATE 1975-92; TRIAZINES to search CYCLOGUANIL PAMOATE 1975-92; metabolite of chloroguanide; antimalarial | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) | 3IRM 3IRN 3UM6 3UM8 4KNE |
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| fenoxypropazine | None | |
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| edrophonium | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) None (Source: CHEMBL) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: CHEMBL) | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | diagnostic agent (Code: CHEBI:33295) antidote (Code: CHEBI:50247) Cholinesterase Inhibitor (Code: N0000175723) Antidotes (Code: D000931) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1951-05-03 FDA | 1AX9 2ACK |
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| ethionamide | Catalase-peroxidase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WIE4, gene: katG, swissprot: KATG_MYCTO) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGR1, gene: inhA, swissprot: INHA_MYCTU) inhibitor (Source: CHEMBL) | A second-line antitubercular agent that inhibits mycolic acid synthesis. | antitubercular agent (Code: CHEBI:33231) antilipemic drug (Code: CHEBI:35679) leprostatic drug (Code: CHEBI:35816) prodrug (Code: CHEBI:50266) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antitubercular Agents (Code: D000995) Fatty Acid Synthesis Inhibitors (Code: D054872) Hypolipidemic Agents (Code: D000960) | 1965-04-30 FDA | |
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| orthocaine | None | |
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| aminosalicylic acid hydrazide | None | |
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| thioguanine | Inosine-5'-monophosphate dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P12268, gene: IMPDH2, swissprot: IMDH2_HUMAN) inhibitor (Source: CHEMBL) Inosine-5'-monophosphate dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P20839, gene: IMPDH1, swissprot: IMDH1_HUMAN) inhibitor (Source: CHEMBL) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: DRUG MATRIX) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Hypoxanthine-guanine phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P00492, gene: HPRT1, swissprot: HPRT_HUMAN) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | 1966-01-18 FDA | 3JQA 3RKF 4M5M 4XOY 4XP3 5XU8 |
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| oxedrine | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: CHEMBL) Neuromedin-U receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9GZQ4, gene: NMUR2, swissprot: NMUR2_HUMAN) None (Source: CHEMBL) | Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. | alpha-adrenergic agonist (Code: CHEBI:35569) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | |
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| pyrithyldione | None | |
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| phenylephrine | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Source: CHEMBL) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) agonist (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) None (Source: CHEMBL) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) None (Source: CHEMBL) | An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. | cardiotonic drug (Code: CHEBI:38147) mydriatic agent (Code: CHEBI:50513) protective agent (Code: CHEBI:50267) vasoconstrictor agent (Code: CHEBI:50514) sympathomimetic agent (Code: CHEBI:35524) nasal decongestant (Code: CHEBI:77715) alpha-adrenergic agonist (Code: CHEBI:35569) alpha-1 Adrenergic Agonist (Code: N0000186105) Adrenergic alpha1-Agonists (Code: N0000009917) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Mydriatics (Code: D009184) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1952-01-21 FDA | |
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| dexmethylphenidate | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: CHEMBL) None (Source: CHEMBL) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) | A methylphenidate derivative, DOPAMINE UPTAKE INHIBITOR and CENTRAL NERVOUS SYSTEM STIMULANT that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. | Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) adrenergic agent (Code: CHEBI:37962) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 2001-11-13 FDA | |
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| metaraminol | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: CHEMBL) | A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION. | alpha-adrenergic agonist (Code: CHEBI:35569) vasoconstrictor agent (Code: CHEBI:50514) sympathomimetic agent (Code: CHEBI:35524) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1954-09-29 FDA | |
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| ethinamate | short duration hypnotic with fast onset & relatively low toxicity; may cause dependence; minor descriptor (76-85); on-line & Index Medicus search CARBAMATES (76-85) | sedative (Code: CHEBI:35717) | 1955-03-13 FDA | |
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| mecamylamine | Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) negative allosteric modulator (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Neuronal acetylcholine receptor subunit alpha-6 (Organism: Homo sapiens, class: Ion channel, accessions: Q15825, gene: CHRNA6, swissprot: ACHA6_HUMAN) blocker (Source: IUPHAR) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P32297, gene: CHRNA3, swissprot: ACHA3_HUMAN) blocker (Source: IUPHAR) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Homo sapiens, class: Ion channel, accessions: P43681, gene: CHRNA4, swissprot: ACHA4_HUMAN) blocker (Source: IUPHAR) Acetylcholine receptor subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P02708, gene: CHRNA1, swissprot: ACHA_HUMAN) blocker (Source: IUPHAR) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297, gene: CHRNA3|CHRNB2, swissprot: ACHA3_HUMAN|ACHB2_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297|Q05901|Q15825, gene: CHRNA3|CHRNA6|CHRNB2|CHRNB3, swissprot: ACHA3_HUMAN|ACHA6_HUMAN|ACHB2_HUMAN|ACHB3_HUMAN) None (Source: CHEMBL) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) None (Source: CHEMBL) | A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. | Autonomic Ganglionic Blocker (Code: N0000175641) Decreased Autonomic Ganglionic Activity (Code: N0000175644) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | 1956-03-01 FDA | |
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| desflurane | Glycine receptor (alpha-1/beta) (Organism: Homo sapiens, class: Ion channel, accessions: P23415|P48167, gene: GLRA1|GLRB, swissprot: GLRA1_HUMAN|GLRB_HUMAN) positive modulator (Source: CHEMBL) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: CHEMBL) Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: CHEMBL) | volatile anesthetic that differs from isoflurane by substitution of a fluorine atom for the chlorine found on the alpha-ethyl component of isoflurane; MF: CF2-O-CFH-CF3; produces anesthetic preconditioning to protect the myocardium against infarction | inhalation anaesthetic (Code: CHEBI:38870) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 1992-09-18 FDA | 3P4W |
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| sulfametrole | None | |
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| cicrotoic acid | None | |
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| zoxazolamine | A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. | Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Gout Suppressants (Code: D006074) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) | 4QP2 |
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| pyridoxine | Phosphoserine aminotransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y617, gene: PSAT1, swissprot: SERC_HUMAN) Cystathionine beta-synthase (Organism: Homo sapiens, class: Enzyme, accessions: P35520, gene: CBS, swissprot: CBS_HUMAN) Pyridoxal kinase (Organism: Homo sapiens, class: Kinase, accessions: O00764, gene: PDXK, swissprot: PDXK_HUMAN) Pyridoxal phosphate phosphatase (Organism: Homo sapiens, class: Enzyme, accessions: Q96GD0, gene: PDXP, swissprot: PLPP_HUMAN) Pyridoxine-5'-phosphate oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q9NVS9, gene: PNPO, swissprot: PNPO_HUMAN) Serine hydroxymethyltransferase, cytosolic (Organism: Homo sapiens, class: Enzyme, accessions: P34896, gene: SHMT1, swissprot: GLYC_HUMAN) | The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B6 Analog (Code: N0000192800) Vitamin B 6 (Code: N0000005657) Analogs/Derivatives (Code: N0000175452) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | 1947-07-28 FDA | 4C5L 4C5N 5EB3 |
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| norepinephrine | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Sorce: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) None (Source: CHEMBL) Adrenergic receptor alpha (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P19328|P22086|P22909|P23944|P43140, gene: Adra1a|Adra1b|Adra1d|Adra2a|Adra2b|Adra2c, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT|ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: CHEMBL) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) agonist (Sorce: CHEMBL) Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) None (Source: CHEMBL) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Sorce: CHEMBL) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P10608, gene: Adrb2, swissprot: ADRB2_RAT) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) None (Source: CHEMBL) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) None (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Sorce: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Sorce: CHEMBL) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) None (Source: PDSP) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Sorce: CHEMBL) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) None (Source: CHEMBL) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) None (Source: CHEMBL) | Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. | Catecholamine (Code: N0000175570) Catecholamines (Code: N0000007715) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1950-07-13 FDA | 3DYE 2QEO 3HCD 4PAH 4Y4J 5N3L |
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| dichlorobenzyl alcohol | None | antiseptic drug (Code: CHEBI:48218) | 1996-12-31 Health Canada | |
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| piperidione | None | |
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| chlorzoxazone | Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) opener (Source: http://www.ncbi.nlm.nih.gov/pubmed/12480161) Intermediate conductance calcium-activated potassium channel protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: O15554, gene: KCNN4, swissprot: KCNN4_HUMAN) opener (Source: IUPHAR) Nitric oxide synthase, brain (Organism: Rattus norvegicus, class: Enzyme, accessions: P29476, gene: Nos1, swissprot: NOS1_RAT) None (Source: DRUG MATRIX) Nitric oxide synthase, inducible (Organism: Homo sapiens, class: Enzyme, accessions: P35228, gene: NOS2, swissprot: NOS2_HUMAN) None (Source: CHEMBL) Nitric oxide synthase, brain (Organism: Homo sapiens, class: Enzyme, accessions: P29475, gene: NOS1, swissprot: NOS1_HUMAN) None (Source: CHEMBL) Nitric oxide synthase, endothelial (Organism: Homo sapiens, class: Enzyme, accessions: P29474, gene: NOS3, swissprot: NOS3_HUMAN) None (Source: CHEMBL) | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | muscle relaxant (Code: CHEBI:51371) sedative (Code: CHEBI:35717) Centrally-mediated Muscle Relaxation (Code: N0000175730) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | 1958-08-15 FDA | 1M8D 1M9J |
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| levetiracetam | Synaptic vesicle glycoprotein 2A (Organism: Homo sapiens, class: Transporter, accessions: Q7L0J3, gene: SV2A, swissprot: SV2A_HUMAN) modulator (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Synaptic vesicle glycoprotein 2A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q02563, gene: Sv2a, swissprot: SV2A_RAT) inhibitor (Source: IUPHAR) | nootropic drug; facilitates memory retrieval in rats | anticonvulsant (Code: CHEBI:35623) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) | 1999-11-30 FDA | |
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| propylthiouracil | Thyroid peroxidase (Organism: Homo sapiens, class: Enzyme, accessions: P07202, gene: TPO, swissprot: PERT_HUMAN) inhibitor (Source: CHEMBL) Type I iodothyronine deiodinase (Organism: Homo sapiens, class: Enzyme, accessions: P49895, gene: DIO1, swissprot: IOD1_HUMAN) inhibitor (Source: CHEMBL) Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) None (Source: CHEMBL) | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | antithyroid drug (Code: CHEBI:50671) hormone antagonist (Code: CHEBI:49020) antidote to paracetamol poisoning (Code: CHEBI:74529) Thyroid Hormone Synthesis Inhibitor (Code: N0000175918) Thyroid Hormone Synthesis Inhibitors (Code: N0000175917) Antimetabolites (Code: D000963) Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Noxae (Code: D009676) | 1947-07-28 FDA | 4QYQ 5HPW |
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| sobrerol | None | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | |
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| metronidazole | A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. Metronidazole, a nitroimidazole, exerts antibacterial effects in an anaerobic environment against most obligate anaerobes. Once metronidazole enters the organism by passive diffusion and activated in the cytoplasm of susceptible anaerobic bacteria, it is reduced; this process includes intracellular electron transport proteins such as ferredoxin, transfer of an electron to the nitro group of the metronidazole, and formation of a short-lived nitroso free radical. Because of this alteration of the metronidazole molecule, a concentration gradient is created and maintained which promotes the drug’s intracellular transport. The reduced form of metronidazole and free radicals can interact with DNA leading to inhibition of DNA synthesis and DNA degradation leading to death of the bacteria. | antitrichomonal drug (Code: CHEBI:50685) prodrug (Code: CHEBI:50266) antibacterial drug (Code: CHEBI:36047) antiparasitic agent (Code: CHEBI:35442) radiosensitizing agent (Code: CHEBI:132992) Nitroimidazole Antimicrobial (Code: N0000175435) Nitroimidazoles (Code: N0000007663) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Radiation-Sensitizing Agents (Code: D011838) | 1963-07-18 FDA | 1W3R |
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| gabapentin | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Homo sapiens, class: Ion channel, accessions: P54289, gene: CACNA2D1, swissprot: CA2D1_HUMAN) modulator (Source: CHEMBL) Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit (Organism: Sus scrofa, class: Ion channel, accessions: O77773, gene: CACNA2D1, swissprot: O77773_PIG) None (Source: CHEMBL) Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Mus musculus, class: Ion channel, accessions: O08532, gene: Cacna2d1, swissprot: CA2D1_MOUSE) None (Source: CHEMBL) Large neutral amino acids transporter small subunit 1 (Organism: Homo sapiens, class: Transporter, accessions: Q01650, gene: SLC7A5, swissprot: LAT1_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Gamma-aminobutyric acid type B receptor subunit 2 (Organism: Homo sapiens, class: GPCR, accessions: O75899, gene: GABBR2, swissprot: GABR2_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Voltage-dependent calcium channel subunit alpha-2/delta-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY47, gene: CACNA2D2, swissprot: CA2D2_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/21651903) | can be viewed as a cyclohexane-GABA; an oral medication for add-on therapy in the treatment of partial seizures in adult epilepsy; inhibits dopamine release from rabbit caudate nucleus | anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Analgesics (Code: D000700) Anti-Anxiety Agents (Code: D014151) Anti-Dyskinesia Agents (Code: D018726) Anticonvulsants (Code: D000927) Antimanic Agents (Code: D018692) Antiparkinson Agents (Code: D000978) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) | 1993-12-30 FDA | 2A1H 2COI 2COJ 2EJ3 |
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| rasagiline | Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: CHEMBL) | TVP-1022 is the (S)-isomer and a cardioprotective agent; monoamine oxidase type-B inhibitor that is not metabolized to amphetamine derivatives; can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods | neuroprotective agent (Code: CHEBI:63726) Monoamine Oxidase Inhibitor (Code: N0000175744) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | 2006-05-16 FDA | 5G6S |
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| iproheptine | None | |
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| menadione | Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: CHEMBL) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) None (Source: CHEMBL) Dual specificity phosphatase Cdc25C (Organism: Homo sapiens, class: Enzyme, accessions: P30307, gene: CDC25C, swissprot: MPIP3_HUMAN) None (Source: CHEMBL) M-phase inducer phosphatase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P30305, gene: CDC25B, swissprot: MPIP2_HUMAN) None (Source: CHEMBL) Dual specificity protein phosphatase 6 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q64346, gene: Dusp6, swissprot: DUS6_RAT) None (Source: CHEMBL) Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Organism: Homo sapiens, class: Enzyme, accessions: P15374, gene: UCHL3, swissprot: UCHL3_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) None (Source: CHEMBL) Dual specificity protein phosphatase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28563, gene: Dusp1, swissprot: DUS1_MOUSE) None (Source: CHEMBL) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) None (Source: CHEMBL) | None | nutraceutical (Code: CHEBI:50733) | None FDA | 1TUV 2QR2 4F8Y |
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| sulfanilamide | Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) None (Source: CHEMBL) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) None (Source: CHEMBL) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Bos taurus, class: Enzyme, accessions: P00921, gene: CA2, swissprot: CAH2_BOVIN) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) None (Source: CHEMBL) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) None (Source: CHEMBL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) None (Source: CHEMBL) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) None (Source: CHEMBL) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) inhibitor (Source: CHEMBL) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) None (Source: CHEMBL) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1965-06-05 FDA | 1AJ0 4COQ 4F92 4F93 |
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| sodium hexacyclonate | used in treatment of hyperlipoproteinemia | |
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| terpin | Terpin hydrate improves mucociliary function by working directly on the bronchial secretory cells in the lower respiratory tract to liquify and facilitate the elimination of bronchial secretions. | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | 2004-06-01 Ministry of Health of the Russian Federation | |
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| loprodiol | None | |
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| oxaceprol | None | Antirheumatic Agents (Code: D018501) Dermatologic Agents (Code: D003879) | 2011-03-15 CDSCO (INDIA) | |
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| acexamic acid | wound-healing agent component of plasmutan | |
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| acetylleucine | used for treating vestibular-related imbalance and vertigo | 2017 EMA | 5AFG |
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| menadiol sulfate | None | |
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| ascorbic acid | Solute carrier family 23 member 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9UHI7, gene: SLC23A1, swissprot: S23A1_HUMAN) Solute carrier family 23 member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UGH3, gene: SLC23A2, swissprot: S23A2_HUMAN) Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q02809, gene: PLOD1, swissprot: PLOD1_HUMAN) Prolyl 4-hydroxylase subunit alpha-1 (Organism: Homo sapiens, class: Enzyme, accessions: P13674, gene: P4HA1, swissprot: P4HA1_HUMAN) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) None (Source: CHEMBL) Pancreatic alpha-amylase (Organism: Rattus norvegicus, class: Unclassified, accessions: P00689, gene: Amy2, swissprot: AMYP_RAT) None (Source: CHEMBL) | A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. | vitamin C (Code: CHEBI:21241) flour treatment agent (Code: CHEBI:64577) food antioxidant (Code: CHEBI:77962) Antioxidants (Code: D000975) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Protective Agents (Code: D020011) Vitamins (Code: D014815) | 1947-07-28 FDA | 1E71 1E72 1E73 1F9G 1OAF 1XID 2X08 2YLD 2YLG 3EKA 3FXR 3TGY 3VLN 3VXI 3ZWI 4CIP 4GPC 4GPH 4JTP 4O79 4O7G 4RP8 4RP9 4TVT 4TWL 5D9W 5JCN 5JLI 5JRA 5JS5 5JSL 5JT4 5KKZ |
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| arginine hydrochloride | Nitric oxide synthase, inducible (Organism: Homo sapiens, class: Enzyme, accessions: P35228, gene: NOS2, swissprot: NOS2_HUMAN) None (Source: CHEMBL) | An essential amino acid that is physiologically active in the L-form. | 1973-02-28 FDA | |
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| carfimate | None | |
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| citrulline | None | None FDA | 4MD5 4MD0 4MD4 1H70 1J1Z 1J21 1K97 1KP3 1LXY 1OL1 1QR3 2C6Z 2JAI 2NZ2 2W65 3B3I 3B6S 3DTX 3FT2 3HCV 3OE0 3ZOP 3ZP4 3ZP7 4GVY 4JQO 4MCY 4MCZ 4MDI 5IV2 5IVZ 5JLZ 5MU0 5MUB 5MV4 5UHR 6ATI 6ATZ 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIZ 6EQV |
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| benzalamide | None | |
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| tidiacic | None | 5FF2 |
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| glucurolactone | None | |
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| hymecromone | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) None (Source: CHEMBL) Testosterone 17-beta-dehydrogenase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P37058, gene: HSD17B3, swissprot: DHB3_HUMAN) None (Source: CHEMBL) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) None (Source: CHEMBL) | A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID. | antineoplastic agent (Code: CHEBI:35610) Indicators and Reagents (Code: D007202) | 2008-07-31 Ministry of Health of the Russian Federation | 3ETS 4AX7 4V28 5IK5 5IK8 5JR3 |
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| pemoline | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: DRUG MATRIX) | A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children. | central nervous system stimulant (Code: CHEBI:35337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) | 1975-01-27 FDA | |
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| cotinine | Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) | The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties. | biomarker (Code: CHEBI:59163) antidepressant (Code: CHEBI:35469) Indicators and Reagents (Code: D007202) | |
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| meptazinol | Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) None (Source: CHEMBL) Cholinesterase (Organism: Mus musculus, class: Enzyme, accessions: Q03311, gene: Bche, swissprot: CHLE_MOUSE) None (Source: CHEMBL) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) partial agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/6141283) | A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain. | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotic Antagonists (Code: D009292) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1983-01-01 YEAR INTRODUCED | |
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| metamfepramone | None | |
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| phenmetrazine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) | A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE. | Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1982-01-01 FDA | |
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| betanidine | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) substrate (Source: CHEMBL) | A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. | antihypertensive agent (Code: CHEBI:35674) adrenergic antagonist (Code: CHEBI:37887) Adrenergic Agents (Code: D018663) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1982-01-01 FDA | |
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| rimantadine | Matrix protein 2 (Organism: Influenza A virus (strain A/Ann Arbor/6/1960 H2N2), class: Ion channel, accessions: P21430, gene: M, swissprot: M2_I60A0) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) None (Source: CHEMBL) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) None (Source: CHEMBL) Matrix protein 2 (Organism: Influenza A virus (strain A/Udorn/307/1972 H3N2), class: Ion channel, accessions: P63231, gene: M, swissprot: M2_I72A2) inhibitor (Source: CHEMBL) | An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. | Influenza A M2 Protein Inhibitor (Code: N0000175543) M2 Protein Inhibitors (Code: N0000175542) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1993-09-17 FDA | 2LJC 2RLF |
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| lidocaine | Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) blocker (Source: CHEMBL) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) blocker (Source: CHEMBL) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) blocker (Source: CHEMBL) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) None (Source: CHEMBL) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) blocker (Source: CHEMBL) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) blocker (Source: CHEMBL) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) blocker (Source: CHEMBL) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Rattus norvegicus, class: Unclassified, accessions: P15389, gene: Scn5a, swissprot: SCN5A_RAT) blocker (Source: IUPHAR) Sodium channel protein type X alpha subunit (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62968, gene: Scn10a, swissprot: SCNAA_RAT) None (Source: IUPHAR) | A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE. | Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Antiarrhythmic (Code: N0000175426) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Anti-Arrhythmia Agents (Code: D000889) drug allergen (Code: CHEBI:88188) local anaesthetic (Code: CHEBI:36333) anti-arrhythmia drug (Code: CHEBI:38070) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1948-11-19 FDA | 3JQZ 3TTR |
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| chlorobutanol | A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics. | Pharmaceutic Aids (Code: D010592) Preservatives, Pharmaceutical (Code: D011310) | 2006 Ministry of Health of the Russian Federation | |
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| phenacemide | Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) | anti-epileptic drug; structure | 1951-06-28 FDA | |
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| nikethamide | A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229) | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) | 1967-07-11 Ministry of Health of the Russian Federation | |
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| propofol | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: DRUG MATRIX) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: DRUG MATRIX) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) None (Source: CHEMBL) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: CHEMBL) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: CHEMBL) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) None (Source: CHEMBL) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: CHEMBL) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Fatty-acid amide hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O00519, gene: FAAH, swissprot: FAAH1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Organism: Mus musculus, class: Ion channel, accessions: O88704, gene: Hcn1, swissprot: HCN1_MOUSE) blocker (Source: IUPHAR) | An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. | intravenous anaesthetic (Code: CHEBI:38877) sedative (Code: CHEBI:35717) antiemetic (Code: CHEBI:50919) anticonvulsant (Code: CHEBI:35623) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1989-10-02 FDA | 1E7A 3F33 3P50 5MUO 5MUR 5MVM 5MVN 5MZR |
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| fluostigmine | Lysosomal protective protein (Organism: Homo sapiens, class: Enzyme, accessions: P10619, gene: CTSA, swissprot: PPGB_HUMAN) None (Source: CHEMBL) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: CHEMBL) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) None (Source: CHEMBL) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: CHEMBL) Liver carboxylesterase (Organism: Sus scrofa, class: Enzyme, accessions: Q29550, gene: None, swissprot: EST1_PIG) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) None (Source: PDSP) | A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM. | Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Protease Inhibitors (Code: D011480) | 1957-04-02 FDA | |
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| glucosamine | None | None FDA | 1E9L 1FI1 1QFF 1QFG 1QGI 1QKC 2VZS 2VZV 2XAD 3CO4 3FXI 3V0W 3VFJ 3VFK 3WQV 3WQW 4CU4 4MFL 4MFP 4MFQ 4OLT 4P7N 4PJZ 4PK0 4Q36 4QWP 4Y9T 4ZZ8 5DGR 5GQB 5GSM 5HWA 5KF8 5KGP 5NNW 5UW4 5W7B 5W7F |
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| salacetamide | a derivative of salicylic acid. It is analgesic, anti-inflammatory and antipyretic agent. | |
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| phenprobamate | Muscle relaxant & tranquiliser | 1964 CDSCO (INDIA) | |
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| phenacetin | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431) | non-narcotic analgesic (Code: CHEBI:35481) peripheral nervous system drug (Code: CHEBI:49110) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1887-01-01 YEAR INTRODUCED | 3EBS |
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| homarylamine | None | |
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| glucose | A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. | Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) | 1946-01-17 FDA | 5YSD |
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| iproniazid | Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/1101049) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/1101049) | An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity. | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | |
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| fudosteine | fudosteine is the (R)-isomer | 2013-08-29 China Food and Drug Administration (CFDA) | |
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| methylephedrine | None | 2013 China Food and Drug Administration (CFDA) | |
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| protionamide | Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) | 2005-07-09 Ministry of Health of the Russian Federation | |
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| mexiletine | Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) blocker (Source: CHEMBL) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) blocker (Source: CHEMBL) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) blocker (Source: CHEMBL) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: CHEMBL) Sodium channel protein type X alpha subunit (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62968, gene: Scn10a, swissprot: SCNAA_RAT) None (Source: CHEMBL) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) blocker (Source: CHEMBL) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) blocker (Source: CHEMBL) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) None (Source: CHEMBL) Sodium channel protein type 9 subunit alpha (Organism: Mus musculus, class: Unclassified, accessions: Q62205, gene: Scn9a, swissprot: SCN9A_MOUSE) None (Source: CHEMBL) | Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties. | anti-arrhythmia drug (Code: CHEBI:38070) Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1985-12-30 FDA | 2VIN |
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| methoxyphenamine | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Neurotransmitter Agents (Code: D018377) | 1969-12-31 New Zealand Medicines and Medical Devices Safety Authority | |
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| memantine | Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) negative allosteric modulator (Source: CHEMBL) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, NMDA 2C (Organism: Rattus norvegicus, class: Ion channel, accessions: Q00961, gene: Grin2c, swissprot: NMDE3_RAT) None (Source: CHEMBL) Glutamate NMDA receptor; GRIN1/GRIN2B (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q13224, gene: GRIN1|GRIN2B, swissprot: NMDE2_HUMAN|NMDZ1_HUMAN) negative allosteric modulator (Source: CHEMBL) Glutamate NMDA receptor; GRIN1/GRIN2A (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q12879, gene: GRIN1|GRIN2A, swissprot: NMDE1_HUMAN|NMDZ1_HUMAN) negative allosteric modulator (Source: CHEMBL) Glutamate receptor ionotropic, NMDA 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q05586, gene: GRIN1, swissprot: NMDZ1_HUMAN) negative allosteric modulator (Source: CHEMBL) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent. | dopaminergic agent (Code: CHEBI:48560) antiparkinson drug (Code: CHEBI:48407) neuroprotective agent (Code: CHEBI:63726) antidepressant (Code: CHEBI:35469) NMDA Receptor Antagonists (Code: N0000020015) N-methyl-D-aspartate Receptor Antagonist (Code: N0000175745) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Neurotransmitter Agents (Code: D018377) | 2003-10-16 FDA | 4TWD |
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| cloxiquine | Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) None (Source: CHEMBL) Methionine aminopeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P53582, gene: METAP1, swissprot: MAP11_HUMAN) None (Source: CHEMBL) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: CHEMBL) | has antitubercular activity | |
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| flurotyl | A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy. | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) | |
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| inositol | An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vitamin B Complex (Code: D014803) | None FDA | 1AOD 1G0I 1IEV 1PTG 1Y7V 2HUO 2OS9 2R71 2X1I 3BXD 3EA2 3NT4 3NTR 3V16 3V1H 4F2B 4I9T 4IRX 4MIO 4MIY 4RU1 4RV3 4RXM 4S3G 4WRE 4WUW 4XF6 4XF7 4YO7 5FYR |
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| galactose | An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood. | |
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| fructose | A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding. | Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) | None FDA | 5XHA 5F11 5GOO 3VSS |
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| acetylsalicylic acid | Gamma-glutamyltranspeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P19440, gene: GGT1, swissprot: GGT1_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: CHEMBL) Acidic phospholipase A2 3 (Organism: Naja sagittifera, class: Enzyme, accessions: P60045, gene: None, swissprot: PA2A3_NAJSG) | The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) | plant activator (Code: CHEBI:73182) drug allergen (Code: CHEBI:88188) platelet aggregation inhibitor (Code: CHEBI:50427) antipyretic (Code: CHEBI:35493) prostaglandin antagonist (Code: CHEBI:49023) anticoagulant (Code: CHEBI:50249) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Decreased Prostaglandin Production (Code: N0000008836) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antipyretics (Code: D058633) Antirheumatic Agents (Code: D018501) Cardiovascular Agents (Code: D002317) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Decreased Platelet Aggregation (Code: N0000008832) Peripheral Nervous System Agents (Code: D018373) Platelet Aggregation Inhibitors (Code: D010975) Sensory System Agents (Code: D018689) | 1950-04-12 FDA 1898-01-01 YEAR INTRODUCED | 1OXR 1TGM 2QQT 3GCL 3IAZ 4NSB |
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| clorindione | Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) None (CHEMBL) | None | |
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| theophylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) inhibitor (Source: CHEMBL) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) inhibitor (Source: CHEMBL) Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) antagonist (Source: CHEMBL) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Bos taurus, class: GPCR, accessions: P28190, gene: ADORA1, swissprot: AA1R_BOVIN) None (Source: CHEMBL) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) antagonist (Source: CHEMBL) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) None (Source: CHEMBL) Adenosine A2a receptor (Organism: Cavia porcellus, class: Unclassified, accessions: P46616, gene: ADORA2A, swissprot: AA2AR_CAVPO) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) None (Source: CHEMBL) Adenosine A2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276|P30543, gene: Adora2a|Adora2b, swissprot: AA2AR_RAT|AA2BR_RAT) None (Source: CHEMBL) Heart phosphodiesterase (Organism: Bos taurus, class: Enzyme, accessions: E1BN64|P14100|Q01061, gene: PDE1A|PDE1B|PDE3B, swissprot: E1BN64_BOVIN|PDE1A_BOVIN|PDE1B_BOVIN) None (Source: CHEMBL) Adenosine receptor A3 (Organism: Rattus norvegicus, class: GPCR, accessions: P28647, gene: Adora3, swissprot: AA3R_RAT) None (Source: CHEMBL) Uncharacterized protein (Organism: Bos taurus, class: Enzyme, accessions: E1BN64, gene: PDE3B, swissprot: E1BN64_BOVIN) None (Source: CHEMBL) Adenosine A2b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276, gene: Adora2b, swissprot: AA2BR_RAT) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) antagonist (Source: CHEMBL) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) antagonist (Source: CHEMBL) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Homo sapiens, class: Enzyme, accessions: P05186, gene: ALPL, swissprot: PPBT_HUMAN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Cavia porcellus, class: GPCR, accessions: P47745, gene: ADORA1, swissprot: AA1R_CAVPO) None (Source: CHEMBL) Adenosine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25099|P28647|P29276|P30543, gene: Adora1|Adora2a|Adora2b|Adora3, swissprot: AA1R_RAT|AA2AR_RAT|AA2BR_RAT|AA3R_RAT) None (Source: CHEMBL) Adenosine receptor A2b (Organism: Mus musculus, class: Unclassified, accessions: Q60614, gene: Adora2b, swissprot: AA2BR_MOUSE) None (Source: IUPHAR) | A plant genus of the family ASTERACEAE. The name "prickly burweed" is sometimes used but causes confusion with AMSINCKIA. | muscle relaxant (Code: CHEBI:51371) bronchodilator agent (Code: CHEBI:35523) vasodilator agent (Code: CHEBI:35620) immunomodulator (Code: CHEBI:50846) anti-inflammatory agent (Code: CHEBI:67079) anti-asthmatic drug (Code: CHEBI:49167) Methylxanthine (Code: N0000175790) Xanthines (Code: N0000008118) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P1 Receptor Antagonists (Code: D058915) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) | 1947-10-17 FDA | 2A3A 3ROX 4EOH 5MZJ 1O15 1EHT |
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| theobromine | 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9) | vasodilator agent (Code: CHEBI:35620) bronchodilator agent (Code: CHEBI:35523) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) | 2EFJ |
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| propylparaben | None | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Pharmaceutic Aids (Code: D010592) Preservatives, Pharmaceutical (Code: D011310) | 4TV1 |
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| mephenesin | A centrally acting muscle relaxant with a short duration of action. | Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | |
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| rilmenidine | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: CHEMBL) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: CHEMBL) Nischarin (Organism: Rattus norvegicus, class: Unclassified, accessions: Q4G017, gene: Nisch, swissprot: NISCH_RAT) None (Source: CHEMBL) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) None (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: CHEMBL) | Rilmenidine is a centrally-acting antihypertensive. It acts through stimulation of central imidazoline receptors and has ?2-adrenoceptor agonist activity. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 2004-12-20 Ministry of Health of the Russian Federation | |
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| tyrosine | A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. | 1975 FDA | 6BQZ 5M8P |
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| styramate | Styramate is a centrally acting skeletal muscle relaxant that was used in the symptomatic treatment of painful muscle spasm associated with musculoskeletal conditions. | |
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| adrenalone | None | Cardiovascular Agents (Code: D002317) Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Vasoconstrictor Agents (Code: D014662) | |
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| acamprosate | Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) antagonist (Source: CHEMBL) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive modulator (Source: CHEMBL) | The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. In vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. | neurotransmitter agent (Code: CHEBI:35942) Alcohol Deterrents (Code: D000427) Central Nervous System Agents (Code: D002491) | 2004-07-29 FDA | |
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| pyridostigmine | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) None (Source: CHEMBL) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: CHEMBL) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) None (Source: CHEMBL) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) None (Source: CHEMBL) | A cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. | Cholinesterase Inhibitor (Code: N0000175723) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) | 1955-04-06 FDA | |
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| oxilofrine | None | |
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| hexapropymate | None | |
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| etilefrine | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/4396765) | A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Adrenergic beta-1 Receptor Agonists (Code: D058665) Adrenergic beta-Agonists (Code: D000318) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1929-01-01 YEAR INTRODUCED | |
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| eflornithine | Ornithine decarboxylase (Organism: Trypanosoma brucei gambiense, class: Enzyme, accessions: Q9TZZ6, gene: None, swissprot: Q9TZZ6_TRYBG) inhibitor (source: http://www.ncbi.nlm.nih.gov/pubmed/3924048) Ornithine decarboxylase (Organism: Rattus norvegicus, class: Unclassified, accessions: P09057, gene: Odc1, swissprot: DCOR_RAT) None (source: CHEMBL) Ornithine decarboxylase (Organism: Homo sapiens, class: Enzyme, accessions: P11926, gene: ODC1, swissprot: DCOR_HUMAN) inhibitor (Source: CHEMBL) | An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway. | Antiprotozoal (Code: N0000175485) Decarboxylase Inhibitor (Code: N0000175845) Decarboxylase Inhibitors (Code: N0000175844) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Ornithine Decarboxylase Inhibitors (Code: D065108) Trypanocidal Agents (Code: D014344) | 1990-11-28 FDA | 2TOD 3GN0 |
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| sorbitol | A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications. | Cathartics (Code: D002400) Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Gastrointestinal Agents (Code: D005765) Indicators and Reagents (Code: D007202) Sweetening Agents (Code: D013549) | 1971-08-20 FDA | 1D8C 1FQA 1FQB 1XIH 2DXR 2VFT 2XIN 3BRF 3XIM 4DVO 4XIA 5A06 5JO9 5K4P 5M6G 5NHA 5XIM 6BJD |
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| mannitol | A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity. | Increased Diuresis (Code: N0000175359) Osmotic Activity (Code: N0000010288) Osmotic Diuretic (Code: N0000175810) Diuretics (Code: D004232) Diuretics, Osmotic (Code: D004234) Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Natriuretic Agents (Code: D045283) Sweetening Agents (Code: D013549) | 1964-06-08 FDA | 1M2W 1P6K 1RS6 1RS7 1ZZQ 1ZZU 2VFU 3N62 3N65 3N66 4D33 4D39 4KCN 4RYA 5VUN 5VUO |
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| glycol salicylate | component of Piadar; topical ointment of the above including 1% methanol in base | None FDA | |
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| sparteine | A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) | |
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| flopropione | Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) inhibitor (Source: http://eisai.jp/medical/products/di/EPI/CSP_C_EPI.pdf) | The mechanism of action is considered to be based on the inhibition of catechol-o-methyl-transferase (COMT), resulting in an adrenergic action, and anti-serotonin action | |
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| dacarbazine | Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) None (Source: DRUG MATRIX) DNA polymerase alpha subunit B (Organism: Homo sapiens, class: Unclassified, accessions: Q14181, gene: POLA2, swissprot: DPOA2_HUMAN) DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) other (Source: CHEMBL) | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564) | antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1975-05-27 FDA | |
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| succimer | lead (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (SourceL http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/019998s013lbl.pdf) | A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. | Lead Chelating Activity (Code: N0000175962) Lead Chelator (Code: N0000175963) Antidotes (Code: D000931) Chelating Agents (Code: D002614) Protective Agents (Code: D020011) Sequestering Agents (Code: D064449) | 1991-01-30 FDA | |
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| guanacline | None | |
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| chlorphentermine | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) substrate (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) | A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223) | Autonomic Agents (Code: D001337) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1982-01-01 FDA | |
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| epinephrine | Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) agonist (Source: CHEMBL) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Source: CHEMBL) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) agonist (Source: CHEMBL) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) agonist (Source: CHEMBL) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) None (Source: DRUG MATRIX) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: CHEMBL) Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) None (Source: CHEMBL) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) None (Source: CHEMBL) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P10608, gene: Adrb2, swissprot: ADRB2_RAT) None (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) None (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: PDSP) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: PDSP) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) None (Source: CHEMBL) M18 aspartyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8I2J3, gene: None, swissprot: Q8I2J3_PLAF7) None (Source: CHEMBL) | The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. | alpha-Adrenergic Agonist (Code: N0000175552) beta-Adrenergic Agonist (Code: N0000175555) Catecholamine (Code: N0000175570) Catecholamines (Code: N0000007715) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1948-11-19 FDA | 2HKK 4A7U 4LDO |
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| methyprylon | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: CHEMBL) | None | None FDA | |
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| epomediol | marked choleretic activity in Wistar rats; mechanism of action may be related to increases in both the bile salt dependent & independent fractions of bile | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) | |
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| clortermine | None | |
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| domiodol | None | |
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| phosphorylcholine | Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction. | 5WP4 |
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| azelaic acid | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P31213, gene: SRD5A2, swissprot: S5A2_HUMAN) | None | antineoplastic agent (Code: CHEBI:35610) dermatologic drug (Code: CHEBI:50177) Decreased Protein Synthesis (Code: N0000008841) Decreased Sebaceous Gland Activity (Code: N0000009982) Antineoplastic Agents (Code: D000970) Dermatologic Agents (Code: D003879) | 1995-09-13 FDA | 1TUF 5IZF 5IZJ 5J5X |
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| barbital | A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression. | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | |
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| mitoguazone | S-adenosylmethionine decarboxylase proenzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P17708, gene: Amd1, swissprot: DCAM_RAT) None (Source: CHEMBL) Amiloride-sensitive amine oxidase [copper-containing] (Organism: Rattus norvegicus, class: Enzyme, accessions: P36633, gene: Aoc1, swissprot: AOC1_RAT) None (Source: CHEMBL) | Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase. | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) | |
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| enflurane | Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: CHEMBL) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) positive modulator (Source: CHEMBL) | An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. | anaesthetic (Code: CHEBI:38867) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 1972-08-28 FDA | |
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| apronal | None | |
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| undecylenic acid | a fatty acid with a terminal double bond | None FDA | |
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| piroctone | 2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis; structure given in first source | antiseborrheic (Code: CHEBI:59010) | |
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| guanazodine | synonyms EGYT-739 & Sanegyt (Sanegit) refers to sulfate; RN given refers to parent cpd | |
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| isoflurane | Glycine receptor (alpha-1/beta) (Organism: Homo sapiens, class: Ion channel, accessions: P23415|P48167, gene: GLRA1|GLRB, swissprot: GLRA1_HUMAN|GLRB_HUMAN) positive modulator (Source: CHEMBL) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: CHEMBL) Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: CHEMBL) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: PDSP) | A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. | inhalation anaesthetic (Code: CHEBI:38870) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 1979-12-18 FDA | 1XZ3 3F78 4Z90 4Z91 |
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| ribavirin | Inosine-5'-monophosphate dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P20839, gene: IMPDH1, swissprot: IMDH1_HUMAN) inhibitor (Source: CHEMBL) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) None (Source: CHEMBL) NS5B protein (Organism: Hepatitis C virus, class: Enzyme, accessions: Q8JXU8, gene: NS5B, swissprot: Q8JXU8_9HEPC) inhibitor (Source: CHEMBL) Cytosolic purine 5'-nucleotidase (Organism: Homo sapiens, class: Enzyme, accessions: P49902, gene: NT5C2, swissprot: 5NTC_HUMAN) Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Organism: Homo sapiens, class: Enzyme, accessions: P22413, gene: ENPP1, swissprot: ENPP1_HUMAN) Adenosine kinase (Organism: Homo sapiens, class: Kinase, accessions: P55263, gene: ADK, swissprot: ADK_HUMAN) Inosine-5'-monophosphate dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P12268, gene: IMPDH2, swissprot: IMDH2_HUMAN) inhibitor (Source: IUPHAR) | A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses. | Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antiviral (Code: N0000175466) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Noxae (Code: D009676) | 1985-12-31 FDA | 3SFU 4PB1 5AXD |
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| secnidazole | 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Organism: Escherichia coli, class: Enzyme, accessions: C3TDZ2, gene: fabH, swissprot: C3TDZ2_ECOLX) None (Source: CHEMBL) | Secnidazole is a 5-nitroimidazole antimicrobial. 5-nitroimidazoles enter the bacterial cell as an inactive prodrug where the nitro group is reduced by bacterial enzymes to radical anions. It is believed that these radical anions interfere with bacterial DNA synthesis of susceptible isolates. | Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | 2017-09-15 FDA | |
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| amanozine | None | 5X4M |
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| procymate | None | |
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| amphenidone | None | |
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| selenomethionine | Diagnostic aid in pancreas function determination. | None FDA | 4FY0 4DLP 4QGN |
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| mafenide | Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) None (Source: CHEMBL) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) None (Source: CHEMBL) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) None (Source: CHEMBL) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: CHEMBL) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) None (Source: CHEMBL) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: CHEMBL) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) None (Source: CHEMBL) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: CHEMBL) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) None (Source: CHEMBL) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: CHEMBL) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) None (Source: CHEMBL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) None (Source: CHEMBL) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) None (Source: CHEMBL) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: CHEMBL) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) None (Source: CHEMBL) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) inhibitor (Source: CHEMBL) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) None (Source: CHEMBL) | A sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. | Methylated Sulfonamide Antibacterial (Code: N0000175511) Methylated Sulfonamides (Code: N0000175512) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | 1969-01-24 FDA | 5JNC |
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| carbimazole | Lactoperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P22079, gene: LPO, swissprot: PERL_HUMAN) None (Source: CHEMBL) Thyroid peroxidase (Organism: Homo sapiens, class: Enzyme, accessions: P07202, gene: TPO, swissprot: PERT_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/1278093) | An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity. | prodrug (Code: CHEBI:50266) antithyroid drug (Code: CHEBI:50671) Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1959-01-01 YEAR INTRODUCED | |
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| cyclobutyrol | None | bile therapy drug (Code: CHEBI:61026) | |
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| capuride | None | |
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| aminitrozole | None | 1971-05-27 Ministry of Health of the Russian Federation | |
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| amrinone | cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) inhibitor (Source: CHEMBL) Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) None (Source: CHEMBL) cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Organism: Homo sapiens, class: Enzyme, accessions: Q13370, gene: PDE3B, swissprot: PDE3B_HUMAN) inhibitor (Source: IUPHAR) | A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. | Calcium Channel Blockers (Code: D002121) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Phosphodiesterase 3 Inhibitors (Code: D058987) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | 1984-07-31 FDA | |
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| phendimetrazine | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: CHEMBL) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) | a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure | Appetite Suppression (Code: N0000175372) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic Amine Anorectic (Code: N0000175423) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) | 1976-07-28 FDA | |
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| pivagabine | None | |
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| selegiline | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: DRUG MATRIX) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Bos taurus, class: Enzyme, accessions: P21398, gene: MAOA, swissprot: AOFA_BOVIN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Bos taurus, class: Enzyme, accessions: P56560, gene: MAOB, swissprot: AOFB_BOVIN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: CHEMBL) Monoamine oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643|P21396, gene: Maoa|Maob, swissprot: AOFA_RAT|AOFB_RAT) None (Source: CHEMBL) | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl. | Monoamine Oxidase Inhibitor (Code: N0000175744) Monoamine Oxidase Type B Inhibitor (Code: N0000175762) Monoamine Oxidase-B Inhibitors (Code: N0000175761) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | 1989-06-05 FDA | |
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| clavulanic acid | Beta-lactamase TEM (Organism: Escherichia coli, class: Enzyme, accessions: P62593, gene: bla; blaT-3; blaT-4;, swissprot: BLAT_ECOLX) inhibitor (Source: CHEMBL) Beta-lactamase GES-13 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: D1MIX9, gene: blaGES-13, swissprot: D1MIX9_PSEAI) None (Source: CHEMBL) Beta-lactamase (Organism: Citrobacter gillenii, class: Enzyme, accessions: A4KCT8, gene: BlaGIL-1, swissprot: A4KCT8_9ENTR) None (Source: CHEMBL) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: P05364, gene: ampC, swissprot: AMPC_ENTCL) None (Source: CHEMBL) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q9EXV5, gene: blaUOE-1, swissprot: Q9EXV5_ECOLX) None (Source: CHEMBL) Carbapenem-hydrolizing beta-lactamase SFC-1 (Organism: Serratia fonticola, class: Enzyme, accessions: Q6JP75, gene: None, swissprot: Q6JP75_SERFO) None (Source: CHEMBL) Carbepenem-hydrolyzing beta-lactamase KPC (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q9F663, gene: bla, swissprot: BLKPC_KLEPN) None (Source: CHEMBL) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q6GWS8, gene: blaTEM-125, swissprot: Q6GWS8_ECOLX) None (Source: CHEMBL) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) None (Source: CHEMBL) Beta-lactamase (Organism: Salmonella enterica subsp. enterica serovar Westhampton, class: Enzyme, accessions: Q2XPY6, gene: blaCTX-M-53, swissprot: Q2XPY6_SALET) None (Source: CHEMBL) Beta-lactamase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: P24735, gene: ampC, swissprot: AMPC_PSEAE) None (Source: CHEMBL) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: A0ZX81, gene: blaSHV-72, swissprot: A0ZX81_KLEPN) None (Source: CHEMBL) Beta-lactamase SHV-5 (Organism: Klebsiella pneumoniae, class: Unclassified, accessions: P0A3M1, gene: bla, swissprot: BLA5_KLEPN) None (Source: CHEMBL) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) None (Source: CHEMBL) Beta-lactamase SHV-1 (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: P0AD64, gene: bla, swissprot: BLA1_KLEPN) None (Source: CHEMBL) Beta-lactamase (Organism: Bacillus clausii, class: Enzyme, accessions: A8RR46, gene: bcl1, swissprot: A8RR46_BACCS) None (Source: CHEMBL) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: A1E3K9, gene: blaSCO-1, swissprot: A1E3K9_ECOLX) None (Source: CHEMBL) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: Q59401, gene: None, swissprot: Q59401_ENTCL) None (Source: CHEMBL) Beta-lactamase SHV-1 (Organism: Escherichia coli, class: Enzyme, accessions: P0AD63, gene: bla, swissprot: BLA1_ECOLX) None (Source: CHEMBL) Beta-lactamase OXA-1 (Organism: Escherichia coli, class: Enzyme, accessions: P13661, gene: bla, swissprot: BLO1_ECOLX) None (Source: CHEMBL) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q4TVR4, gene: blaSHV-55, swissprot: Q4TVR4_KLEPN) None (Source: CHEMBL) Class D beta-lactamase (Organism: Brachyspira pilosicoli, class: Unclassified, accessions: Q50H31, gene: oxa-63, swissprot: Q50H31_BRAPL) None (Source: CHEMBL) Beta-lactamase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P00807, gene: blaZ, swissprot: BLAC_STAAU) None (Source: CHEMBL) | Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase. | antibacterial drug (Code: CHEBI:36047) anxiolytic drug (Code: CHEBI:35474) beta Lactamase Inhibitor (Code: N0000175930) beta Lactamase Inhibitors (Code: N0000000202) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) beta-Lactamase Inhibitors (Code: D065093) Enzyme Inhibitors (Code: D004791) | 1984-08-06 FDA | 2JAP 2XF3 2XFS 2XH9 |
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| aceglutamide | None | 2013 China Food and Drug Administration (CFDA) | 1XPY 2GGH |
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| fluoresone | None | |
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| phenazone | Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/25765567) | An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29) | opioid analgesic (Code: CHEBI:35482) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1964-01-01 YEAR INTRODUCED | |
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| promoxolane | None | |
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| droxidopa | Adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550|P08588|P08913|P13945|P18089|P18825|P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN|ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN|ADRB1_HUMAN|ADRB2_HUMAN|ADRB3_HUMAN) agonist (Source: CHEMBL) | A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) | prodrug (Code: CHEBI:50266) vasoconstrictor agent (Code: CHEBI:50514) antihypertensive agent (Code: CHEBI:35674) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Catecholamines (Code: N0000007715) Increased Blood Pressure (Code: N0000178478) | 2014-02-18 FDA | |
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| fenproporex | an anorectic drug used in the treatment of obesity | 1975 YEAR INTRODUCED | |
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| etryptamine | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: CHEMBL) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) None (Source: CHEMBL) | None | 1961 YEAR INTRODUCED | |
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| unithiol | A chelating agent used as an antidote to heavy metal poisoning. | Antidotes (Code: D000931) Chelating Agents (Code: D002614) Protective Agents (Code: D020011) Sequestering Agents (Code: D064449) | 1964-04-30 Ministry of Health of the Russian Federation | |
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| phensuximide | Voltage-gated T-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43497|O95180|Q9P0X4, gene: CACNA1G|CACNA1H|CACNA1I, swissprot: CAC1G_HUMAN|CAC1H_HUMAN|CAC1I_HUMAN) blocker (Source: CHEMBL) | an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex (Source: DRUGBANK) | 1953-09-08 FDA | |
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| azacitidine | DNA (cytosine-5)-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P26358, gene: DNMT1, swissprot: DNMT1_HUMAN) inhibitor (Source: CHEMBL) DNA (cytosine-5)-methyltransferase 3A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6K1, gene: DNMT3A, swissprot: DNM3A_HUMAN) inhibitor (Source: CHEMBL) | A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent. | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) | 2004-05-19 FDA | 4QD3 |
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| thiotepa | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) other (Source: CHEMBL) | A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed). The radiomimetic action of thiotepa is believed to occur through the release of ethyleneimine radicals which, like irradiation, disrupt the bonds of DNA. One of the principle bond disruptions is initiated by alkylation of guanine at the N-7 position, which severs the linkage between the purine base and the sugar and liberates alkylated guanines. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Myeloablative Agonists (Code: D019653) Noxae (Code: D009676) | 1959-03-09 FDA | |
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| chromocarb | treatment for certain forms of hemorrhagic anal inflammations | |
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| pentamethonium bromide | None | |
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| carglumic acid | Carbamoyl-phosphate synthase [ammonia], mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P31327, gene: CPS1, swissprot: CPSM_HUMAN) positive allosteric modulator (Source: CHEMBL) | carglumic acid could be helpful in lowering plasma ammonia levels over 400 micromol/L more rapidly; a synthetic structural analogue of N-acetylglutamate (NAG), which is an essential allosteric activator of carbamoyl phosphate synthetase 1 (CPS 1) in liver mitochondria | orphan drug (Code: CHEBI:71031) Carbamoyl Phosphate Synthetase 1 Activator (Code: N0000184144) Carbamoyl Phosphate Synthetase 1 Activators (Code: N0000184143) | 2010-03-18 FDA | |
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| dioxybenzone | None | None FDA | |
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| nitroxoline | Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) None (Source: CHEMBL) Cathepsin B (Organism: Homo sapiens, class: Enzyme, accessions: P07858, gene: CTSB, swissprot: CATB_HUMAN) None (Source: CHEMBL) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) None (Source: CHEMBL) | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antifungal Agents (Code: D000935) Renal Agents (Code: D012076) | 2006-06-09 Ministry of Health of the Russian Federation | 3AI8 5Y1Y |
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| procodazole | None | 3KAC |
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| dihydralazine | 1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354) | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | |
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| isosorbide mononitrate | Soluble guanylate cyclase (Organism: Homo sapiens, class: Enzyme, accessions: O75343|P33402|Q02108|Q02153, gene: GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3, swissprot: GCYA2_HUMAN|GCYA3_HUMAN|GCYB1_HUMAN|GCYB2_HUMAN) activator (Source: CHEMBL) Atrial natriuretic peptide receptor 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16066, gene: NPR1, swissprot: ANPRA_HUMAN) | The principal pharmacological action of isosorbide mononitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction and coronary dilatation remains undefined. | vasodilator agent (Code: CHEBI:35620) Nitrate Vasodilator (Code: N0000175415) Nitrates (Code: N0000007647) Vasodilation (Code: N0000009909) Cardiovascular Agents (Code: D002317) Nitric Oxide Donors (Code: D020030) Vasodilator Agents (Code: D014665) | 1991-12-30 FDA | |
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| idrocilamide | None | |
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| amiphenazole | used as a respiratory tonic, morphine antagonist, & antidote in barbiturate poisoning; RN given refers to parent cpd; sturcture | Respiratory System Agents (Code: D019141) | |
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| oxidronic acid | This radiopharmaceutical diagnostic agent, when reconstituted with ADDITIVE-FREE sodium pertechnetate Tc 99m forms a complex of unknown structure | None FDA | |
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| citric acid | 3-dehydroquinate dehydratase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: Q48255, gene: aroQ, swissprot: AROQ_HELPY) None (Source: CHEMBL) 3-dehydroquinate dehydratase (Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145), class: Enzyme, accessions: P15474, gene: aroQ, swissprot: AROQ_STRCO) None (Source: CHEMBL) pH (H+ ion activity) (Organism: None, class: Unclassified, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/019481s013lbl.pdf) Transient receptor potential cation channel subfamily V member 4 (Organism: Mus musculus, class: Unclassified, accessions: Q9EPK8, gene: Trpv4, swissprot: TRPV4_MOUSE) activator (Source: IUPHAR) | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. | food acidity regulator (Code: CHEBI:64049) Acidifying Activity (Code: N0000175833) Calculi Dissolution Agent (Code: N0000175835) Anti-coagulant (Code: N0000175980) Decreased Coagulation Factor Activity (Code: N0000008556) Calcium Chelating Activity (Code: N0000175089) Anticoagulants (Code: D000925) Calcium Chelating Agents (Code: D065096) Chelating Agents (Code: D002614) Hematologic Agents (Code: D006401) Sequestering Agents (Code: D064449) | 1982-06-22 FDA | 6APF |
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| clonitrate | None | |
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| ibufenac | Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) inhibitor (Source: CHEMBL) | used in the treatment of rheumatism; also possesses antipyretic properties; minor descriptor (75-84); on-line & Index Medicus search PHENYLACETATES (75-84); RN given refers to parent cpd | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) | |
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| tocainide | Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) blocker (Source: CHEMBL) | An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS. | anti-arrhythmia drug (Code: CHEBI:38070) local anaesthetic (Code: CHEBI:36333) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1984-11-09 FDA | |
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| bitoscanate | anthelmintic; minor descriptor (75-83); on-line & Index Medicus search THIOCYANATES (75-83); structure | 1970 CDSCO (INDIA) | |
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| glucuronamide | None | |
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| carbaryl | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) None (Source: CHEMBL) Acetylcholinesterase (Organism: Laodelphax striatella, class: Enzyme, accessions: K4JQ36, gene: ace2, swissprot: K4JQ36_9HEMI) None (Source: CHEMBL) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: CHEMBL) Acetylcholinesterase (Organism: Musca domestica, class: Enzyme, accessions: Q7YWJ9, gene: Ache, swissprot: Q7YWJ9_MUSDO) None (Source: CHEMBL) Ace-orthologous acetylcholinesterase; Acetylcholinesterase (Organism: Nephotettix cincticeps, class: Unclassified, accessions: Q9NJH6, gene: AO-AChE, swissprot: Q9NJH6_NEPCI) None (Source: CHEMBL) | A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries. | carbamate insecticide (Code: CHEBI:38461) acaricide (Code: CHEBI:22153) agrochemical (Code: CHEBI:33286) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Insecticides (Code: D007306) Neurotransmitter Agents (Code: D018377) Pesticides (Code: D010575) | |
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| betamipron | Solute carrier family 22 member 8 (Organism: Homo sapiens, class: Transporter, accessions: Q8TCC7, gene: SLC22A8, swissprot: S22A8_HUMAN) Solute carrier family 22 member 6 (Organism: Homo sapiens, class: Transporter, accessions: Q4U2R8, gene: SLC22A6, swissprot: S22A6_HUMAN) | None | 1993-01-01 YEAR INTRODUCED | 3FGD |
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| actarit | immunomodulator | 2008-07-22 CDSCO (INDIA) | |
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| butamben | None | local anaesthetic (Code: CHEBI:36333) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| fenozolone | None | Autonomic Agents (Code: D001337) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | |
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| tryptophan | Probable G-protein coupled receptor 139 (Organism: Homo sapiens, class: Unclassified, accessions: Q6DWJ6, gene: GPR139, swissprot: GP139_HUMAN) agonist (Source: IUPHAR) | An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals. | Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | 1975 FDA | 6CXU 6GG5 6G2P |
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| sabcomeline | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: CHEMBL) | selective for M1 receptors; RN refers to (R,S)-isomer | |
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| etafedrine | None | |
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| temozolomide | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021029s028lbl.pdf) | Temozolomide is not directly active but undergoes rapid nonenzymatic conversion at physiologic pH to the reactive compound 5-(3-methyltriazen1-yl)-imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is thought to be primarily due to alkylation of DNA. | antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1999-08-11 FDA | |
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| ibuprofen | Acid-sensing ion channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: P78348, gene: ASIC1, swissprot: ASIC1_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/28949138) Prostaglandin-H2 D-isomerase (Organism: Mus musculus, class: Enzyme, accessions: O09114, gene: Ptgds, swissprot: PTGDS_MOUSE) None (Source: CHEMBL) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Bos taurus, class: Enzyme, accessions: O62698, gene: PTGS2, swissprot: PGH2_BOVIN) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) None (Source: CHEMBL) Serum albumin (Organism: Bos taurus, class: Secreted, accessions: P02769, gene: ALB, swissprot: ALBU_BOVIN) None (Source: CHEMBL) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) None (Source: CHEMBL) Dehydrogenase/reductase SDR family member 9 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q8VD48, gene: Dhrs9, swissprot: DHRS9_RAT) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) None (Source: CHEMBL) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) None (Source: CHEMBL) Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) None (Source: CHEMBL) Solute carrier family 22 member 6 (Organism: Mus musculus, class: Transporter, accessions: Q8VC69, gene: Slc22a6, swissprot: S22A6_MOUSE) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: CHEMBL) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Sodium-coupled monocarboxylate transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q8N695, gene: SLC5A8, swissprot: SC5A8_HUMAN) inhibitor (Source: IUPHAR) Interleukin-8 (Organism: Homo sapiens, class: Cytokine, accessions: P10145, gene: CXCL8, swissprot: IL8_HUMAN) None (Source: CHEMBL) | A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1974-08-27 FDA | 1EQG 2BXG 2PWS 2WD9 3IB2 3P6G 3P6H 3R8G 3VM4 4JTR 4PH9 4RS0 5JQB |
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| aminohippuric acid | Solute carrier family 22 member 6 (Organism: Mus musculus, class: Transporter, accessions: Q8VC69, gene: Slc22a6, swissprot: S22A6_MOUSE) None (Source: CHEMBL) Solute carrier family 22 member 6 (Organism: Homo sapiens, class: Transporter, accessions: Q4U2R8, gene: SLC22A6, swissprot: S22A6_HUMAN) None (Source: CHEMBL) | The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. | Indicators and Reagents (Code: D007202) | 1944-12-30 FDA | |
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| enprofylline | Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) None (Source: CHEMBL) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) None (Source: CHEMBL) Adenosine A2a receptor (Organism: Cavia porcellus, class: Unclassified, accessions: P46616, gene: ADORA2A, swissprot: AA2AR_CAVPO) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) None (Source: CHEMBL) Adenosine receptor A3 (Organism: Rattus norvegicus, class: GPCR, accessions: P28647, gene: Adora3, swissprot: AA3R_RAT) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Cavia porcellus, class: GPCR, accessions: P47745, gene: ADORA1, swissprot: AA1R_CAVPO) None (Source: CHEMBL) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) | None | bronchodilator agent (Code: CHEBI:35523) anti-asthmatic drug (Code: CHEBI:49167) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) anti-arrhythmia drug (Code: CHEBI:38070) Adenosine A2 Receptor Antagonists (Code: D058917) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P1 Receptor Antagonists (Code: D058915) Respiratory System Agents (Code: D019141) | |
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| caffeine | Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) antagonist (Source: CHEMBL) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) antagonist (Source: CHEMBL) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) None (Source: CHEMBL) Guanine deaminase (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2T3, gene: GDA, swissprot: GUAD_HUMAN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Bos taurus, class: GPCR, accessions: P28190, gene: ADORA1, swissprot: AA1R_BOVIN) None (Source: CHEMBL) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) None (Source: CHEMBL) Adenosine A2a receptor (Organism: Cavia porcellus, class: Unclassified, accessions: P46616, gene: ADORA2A, swissprot: AA2AR_CAVPO) None (Source: CHEMBL) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) None (Source: CHEMBL) Adenosine A2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276|P30543, gene: Adora2a|Adora2b, swissprot: AA2AR_RAT|AA2BR_RAT) None (Source: CHEMBL) Glycogen phosphorylase, muscle form (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P00489, gene: PYGM, swissprot: PYGM_RABIT) None (Source: CHEMBL) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: CHEMBL) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) antagonist (Source: CHEMBL) Adenosine receptor A1 (Organism: Cavia porcellus, class: GPCR, accessions: P47745, gene: ADORA1, swissprot: AA1R_CAVPO) None (Source: CHEMBL) Adenosine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25099|P28647|P29276|P30543, gene: Adora1|Adora2a|Adora2b|Adora3, swissprot: AA1R_RAT|AA2AR_RAT|AA2BR_RAT|AA3R_RAT) None (Source: CHEMBL) Adenosine receptor A2b (Organism: Mus musculus, class: Unclassified, accessions: Q60614, gene: Adora2b, swissprot: AA2BR_MOUSE) antagonist (Source: IUPHAR) | A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. | psychotropic drug (Code: CHEBI:35471) diuretic (Code: CHEBI:35498) food additive (Code: CHEBI:64047) adjuvant (Code: CHEBI:60809) central nervous system stimulant (Code: CHEBI:35337) Central Nervous System Stimulation (Code: N0000175729) Methylxanthine (Code: N0000175790) Xanthines (Code: N0000008118) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Phosphodiesterase Inhibitors (Code: D010726) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P1 Receptor Antagonists (Code: D058915) | 1948-11-26 FDA | 1C8L 1GFZ 1L5Q 1L7X 2A3B 3DD1 3DDS 3DDW 3G6M 3RFM 4Y4D 5MZP |
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| phenamine | None | |
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| ethotoin | Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) blocker (Source: CHEMBL) | Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. | anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1957-04-22 FDA | |
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| aminoacridine | Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) None (Source: CHEMBL) | A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Coloring Agents (Code: D004396) Fluorescent Dyes (Code: D005456) Indicators and Reagents (Code: D007202) Luminescent Agents (Code: D049408) Mutagens (Code: D009153) Noxae (Code: D009676) | 1988-09-08 New Zealand Medicines and Medical Devices Safety Authority | 3TZB |
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| hexylresorcinol | Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: CHEMBL) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) None (Source: CHEMBL) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) None (Source: CHEMBL) | A substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | None FDA | |
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| salamidacetic acid | None | |
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| buramate | None | |
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| phenallymal | None | |
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| metirosine | Tyrosine 3-monooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P07101, gene: TH, swissprot: TY3H_HUMAN) inhibitor (Source: CHEMBL) | An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed) | antihypertensive agent (Code: CHEBI:35674) Catecholamine Synthesis Inhibitor (Code: N0000175569) Catecholamine Synthesis Inhibitors (Code: N0000175361) | 1979-10-03 FDA | |
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| amisometradine | None | |
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| aminometradine | None | 1954 YEAR INTRODUCED | |
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| pimeclone | None | |
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| flurbiprofen | Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) None (Source: CHEMBL) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) None (Source: CHEMBL) Fatty acid-binding protein, intestinal (Organism: Homo sapiens, class: Cytosolic other, accessions: P12104, gene: FABP2, swissprot: FABPI_HUMAN) None (Source: CHEMBL) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63921, gene: Ptgs1, swissprot: PGH1_RAT) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: CHEMBL) | An anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1986-12-31 FDA | 1CQE 1DVT 1EQH 1R9O 2AYL 3N8W 3N8Z 3PGH 3R94 3RR3 4FOR 4JTQ 5JVZ |
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| gluconic acid | zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted | 1BGG 1XLF 3O03 3OY8 3QKE 3T6C 3TWB 4K2S 4ZLG |
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| bismuth camphocarbonate | None | |
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| creatinolfosfate | 1968 YEAR INTRODUCED | |
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| levodopa | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: DRUG MATRIX) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: DRUG MATRIX) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/7878037) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/7878037) | The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. | antidyskinesia agent (Code: CHEBI:66956) dopaminergic agent (Code: CHEBI:48560) antiparkinson drug (Code: CHEBI:48407) prodrug (Code: CHEBI:50266) Aromatic Amino Acid Decarboxylation Inhibitor (Code: N0000175754) DOPA Decarboxylase Inhibitors (Code: N0000175755) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Neurotransmitter Agents (Code: D018377) Aromatic Amino Acid (Code: N0000193220) Amino Acids, Aromatic (Code: N0000011248) | 1970-06-04 FDA | 1IVV 1RNR 2VH3 2ZWE 2ZWF 2ZWG 3TEG 3TEH 4EIS 4P6S 5XDH 6PAH |
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| ethylnorepinephrine | None | |
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| pildralazine | None | |
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| beclamide | None | None Ministry of Health of the Russian Federation | |
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| nitrofurazone | Snake venom metalloproteinase Bap1 (Organism: Bothrops asper, class: Unclassified, accessions: P83512, gene: None, swissprot: VM1B1_BOTAS) None (Source: CHEMBL) Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) | A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS. | antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) | 1945-10-04 FDA | 1YKI 3R6W |
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| mimosine | Ribonucleoside-diphosphate reductase large subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P08543, gene: None, swissprot: RIR1_HHV11) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) Serine hydroxymethyltransferase, cytosolic (Organism: Homo sapiens, class: Enzyme, accessions: P34896, gene: SHMT1, swissprot: GLYC_HUMAN) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: CHEMBL) | 3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca. | 5M8N 5M8R |
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| guaifenesin | An expectorant that also has some muscle relaxing action. It is used in many cough preparations. | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | 2002-07-12 FDA | |
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| metharbital | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: CHEMBL) | None | None FDA | |
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| tacrine | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: DRUG MATRIX) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) None (Source: DRUG MATRIX) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) None (Source: DRUG MATRIX) Glutamate NMDA receptor; GRIN1/GRIN2A (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q12879, gene: GRIN1|GRIN2A, swissprot: NMDE1_HUMAN|NMDZ1_HUMAN) None (Source: CHEMBL) Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: CHEMBL) Acetylcholine receptor subunit epsilon (Organism: Homo sapiens, class: Ion channel, accessions: Q04844, gene: CHRNE, swissprot: ACHE_HUMAN) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Mus musculus, class: GPCR, accessions: Q9ERZ4, gene: Chrm2, swissprot: ACM2_MOUSE) None (Source: CHEMBL) Muscarinic acetylcholine receptor M2 (Organism: Sus scrofa, class: GPCR, accessions: P06199, gene: CHRM2, swissprot: ACM2_PIG) None (Source: CHEMBL) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) None (Source: CHEMBL) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: CHEMBL) Histamine N-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q01984, gene: Hnmt, swissprot: HNMT_RAT) None (Source: CHEMBL) Choline O-acetyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P32738, gene: Chat, swissprot: CLAT_RAT) None (Source: CHEMBL) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) None (Source: CHEMBL) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) None (Source: CHEMBL) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) None (Source: CHEMBL) Glutamate NMDA receptor; GRIN1/GRIN2B (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q13224, gene: GRIN1|GRIN2B, swissprot: NMDE2_HUMAN|NMDZ1_HUMAN) None (Source: CHEMBL) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Mus musculus, class: GPCR, accessions: P12657, gene: Chrm1, swissprot: ACM1_MOUSE) None (Source: CHEMBL) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) None (Source: CHEMBL) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24508831) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) None (Source: CHEMBL) | A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. | Cholinesterase Inhibitor (Code: N0000175723) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Nootropic Agents (Code: D018697) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 1993-09-09 FDA | 1ACJ 1MX1 2AOW 2AOX 4BDS |
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| guanethidine | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) substrate (Source: CHEMBL) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. | antihypertensive agent (Code: CHEBI:35674) adrenergic antagonist (Code: CHEBI:37887) sympatholytic agent (Code: CHEBI:66991) Adrenergic Agents (Code: D018663) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1960-07-05 FDA | |
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| oxophenarsine | obsolete toxic arsenical for treatment of syphilis; useful against some neoplasms; major descriptor (64-83); on-line search ARSENICALS (64-83); Index Medicus search OXOPHENARSINE (64-83); structure; RN given refers to parent cpd | |
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| diethylcarbamazine | Nematode GABA-A receptor (Organism: Loa loa, class: Ion channel, accessions: E1FVX6|E1G1C3, gene: None, swissprot: E1FVX6_LOALO|E1G1C3_LOALO) positive modulator (Source: CHEMBL) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa. | Antihelminthic (Code: N0000175481) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Enzyme Inhibitors (Code: D004791) Filaricides (Code: D005369) Lipoxygenase Inhibitors (Code: D016859) | 1950-11-13 FDA | |
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| cevimeline | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) agonist (source: CHEMBL) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | Cevimeline is a cholinergic agonist which binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can increase secretion of exocrine glands, such as salivary and sweat glands and increase tone of the smooth muscle in the gastrointestinal and urinary tracts. | muscarinic agonist (Code: CHEBI:38325) Cholinergic Muscarinic Agonists (Code: N0000000104) Cholinergic Receptor Agonist (Code: N0000175884) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 2000-01-11 FDA | |
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| octamylamine | None | |
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| sevoflurane | Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) positive modulator (Source: CHEMBL) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: CHEMBL) Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: CHEMBL) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: CHEMBL) | None | inhalation anaesthetic (Code: CHEBI:38870) platelet aggregation inhibitor (Code: CHEBI:50427) central nervous system depressant (Code: CHEBI:35488) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | 1995-06-07 FDA | |
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| pyrovalerone | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: CHEMBL) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: CHEMBL) | None | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) | |
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| monobenzone | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) None (Source: DRUG MATRIX) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) inhibitor (Source: CHEMBL) | The topical application of monobenzone in animals, increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation. | dermatologic drug (Code: CHEBI:50177) melanin synthesis inhibitor (Code: CHEBI:64933) Depigmenting Activity (Code: N0000175851) Depigmenting Agent (Code: N0000175853) Melanin Synthesis Inhibitors (Code: N0000175850) | 1952-11-10 FDA | |
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| tetryzoline | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Adrenergic receptor alpha (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P19328|P22086|P22909|P23944|P43140, gene: Adra1a|Adra1b|Adra1d|Adra2a|Adra2b|Adra2c, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT|ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) Adrenergic receptor alpha (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825|P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN|ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) agonist (Source: CHEMBL) | used as nasal decongestant; Visine is a form of eye drops | nasal decongestant (Code: CHEBI:77715) sympathomimetic agent (Code: CHEBI:35524) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Ophthalmic Solutions (Code: D009883) Peripheral Nervous System Agents (Code: D018373) Pharmaceutical Solutions (Code: D019999) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1979-11-30 FDA | |
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| medetomidine | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) | An agonist of RECEPTORS, ADRENERGIC ALPHA-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of DEXMEDETOMIDINE. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| dexmedetomidine | Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) agonist (Source: CHEMBL) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) agonist (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) None (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: PDSP) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) None (Source: PDSP) | A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound. | sedative (Code: CHEBI:35717) non-narcotic analgesic (Code: CHEBI:35481) analgesic (Code: CHEBI:35480) alpha-adrenergic agonist (Code: CHEBI:35569) Adrenergic alpha2-Agonists (Code: N0000009918) Central alpha-2 Adrenergic Agonist (Code: N0000175554) General Anesthesia (Code: N0000175975) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1999-12-17 FDA | |
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| thiabendazole | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Organism: Caenorhabditis elegans, class: Enzyme, accessions: Q09508, gene: sdha-1, swissprot: SDHA_CAEEL) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) None (Source: DRUG MATRIX) Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) None (Source: CHEMBL) Methionine aminopeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P53582, gene: METAP1, swissprot: MAP11_HUMAN) None (Source: CHEMBL) Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) None (Source: CHEMBL) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) None (Source: CHEMBL) Methionine aminopeptidase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AE18, gene: map, swissprot: MAP1_ECOLI) None (Source: CHEMBL) Tubulin (Organism: Echinococcus granulosus, class: Structural, accessions: C4PKY4|C4PKZ2|C4PKZ6, gene: None, swissprot: C4PKY4_ECHGR|C4PKZ2_ECHGR|C4PKZ6_ECHGR) inhibitor (Source: CHEMBL) Tubulin (Organism: Ascaris suum, class: Structural, accessions: F1L005|F1L4P8|F1L5G6|F1L7U3|F1L7Y0|F1L8A5|F1LCS0, gene: None, swissprot: F1L005_ASCSU|F1L4P8_ASCSU|F1L5G6_ASCSU|F1L7U3_ASCSU|F1L7Y0_ASCSU|F1L8A5_ASCSU|F1LCS0_ASCSU) inhibitor (Source: CHEMBL) | 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919) | antifungal agrochemical (Code: CHEBI:86328) antinematodal drug (Code: CHEBI:35444) Antihelminthic (Code: N0000175481) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | 1967-04-07 FDA | 1YVM 3SFE |
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| indanazoline | It stimulates the alpha 1-adrenergic receptors. It causes vasoconstriction, reduces swelling of the nasal mucosa and nasopharynx, nasal breathing easier by reducing the blood flow to the venous sinuses. | None Ministry of Health of the Russian Federation | |
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| spizofurone | None | |
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| carbromal | None | |
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| amezinium metilsulfate | None | Autonomic Agents (Code: D001337) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | None Ministry of Health of the Russian Federation | |
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| acetylcarnitine | An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS. | Central Nervous System Agents (Code: D002491) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Nootropic Agents (Code: D018697) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | 2007-12-11 Ministry of Health of the Russian Federation | |
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| chloramphenicol palmitate | None | 2014 China Food and Drug Administration (CFDA) | |
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| methsuximide | Voltage-gated T-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43497|O95180|Q9P0X4, gene: CACNA1G|CACNA1H|CACNA1I, swissprot: CAC1G_HUMAN|CAC1H_HUMAN|CAC1I_HUMAN) blocker (Source: CHEMBL) | anticonvulsant effective in petit mal & psychomotor epilepsy; has a number of unpleasant & toxic side effects; minor descriptor (75-86); on-line & INDEX MEDICUS search SUCCINIMIDES (75-86); RN given refers to parent cpd without isomeric designation | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1957-02-08 FDA | |
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| crotamiton | antiscabies, antipruritic drug; active ingredient in Eurax Cream & Lotion (Geigy); request from searcher 3/76; structure | scabicide (Code: CHEBI:73333) antipruritic drug (Code: CHEBI:59683) Pesticides (Code: D010575) | 1949-07-06 FDA | |
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| tretamine | Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers. | insect sterilant (Code: CHEBI:67105) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| levamisole | Acetylcholine receptor subunit alpha-type unc-63 (Organism: Caenorhabditis elegans, class: Ion channel, accessions: Q9N587, gene: unc-63, swissprot: ACH6_CAEEL) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) None (Source: DRUG MATRIX) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Homo sapiens, class: Enzyme, accessions: P05186, gene: ALPL, swissprot: PPBT_HUMAN) None (Source: CHEMBL) Nicotinic acetylcholine receptor alpha subunit (Organism: Ascaris suum, class: Ion channel, accessions: O96760, gene: None, swissprot: O96760_ASCSU) agonist (Source: CHEMBL) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Bos taurus, class: Unclassified, accessions: P09487, gene: ALPL, swissprot: PPBT_BOVIN) None (Source: CHEMBL) | An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6) | antinematodal drug (Code: CHEBI:35444) antirheumatic drug (Code: CHEBI:35842) immunomodulator (Code: CHEBI:50846) immunological adjuvant (Code: CHEBI:50847) Adjuvants, Immunologic (Code: D000276) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Antirheumatic Agents (Code: D018501) Immunologic Factors (Code: D007155) | 1990-06-18 FDA | |
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| ethambutol | Probable arabinosyltransferase A (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WNL8, gene: embA, swissprot: EMBA_MYCTO) Probable arabinosyltransferase B (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WNL6, gene: embB, swissprot: EMBB_MYCTO) Probable arabinosyltransferase C (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WNL5, gene: embC, swissprot: EMBC_MYCTU) Probable arabinosyltransferase A (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WNL9, gene: embA, swissprot: EMBA_MYCTU) inhibitor (Source: CHEMBL) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) | An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863) | antitubercular agent (Code: CHEBI:33231) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) | 1967-11-06 FDA | 5NR3 |
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| guanoxan | was MH 1976-92 (see under GUANIDINES 1976-90); use GUANIDINES to search GUANOXAN 1976-92; antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage | 2015 China Food and Drug Administration (CFDA) | |
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| etifelmine | None | 1963 YEAR INTRODUCED | |
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| telmesteine | None | |
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| dexpanthenol | The alcohol of pantothenic acid | cholinergic drug (Code: CHEBI:38323) | 1947-07-08 FDA | 3AVP |
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| trapidil | A coronary vasodilator agent. | Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Phosphodiesterase Inhibitors (Code: D010726) Platelet Aggregation Inhibitors (Code: D010975) Vasodilator Agents (Code: D014665) | |
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| phenformin | 5'-AMP-activated protein kinase subunit beta-1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y478, gene: PRKAB1, swissprot: AAKB1_HUMAN) | A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290) | antineoplastic agent (Code: CHEBI:35610) Hypoglycemic Agents (Code: D007004) | 5UIH |
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| pheneturide | product of ring hydrolysis of phenobarbital; structure; RN given refers to parent cpd without isomeric designation | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | |
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| diethylpropion | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: CHEMBL) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: CHEMBL) | A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290) | appetite depressant (Code: CHEBI:50507) Appetite Suppression (Code: N0000175372) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic Amine Anorectic (Code: N0000175423) Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Central Nervous System Agents (Code: D002491) | 1959-08-06 FDA | |
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| tosylchloramide sodium | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Disinfectants (Code: D004202) Indicators and Reagents (Code: D007202) Noxae (Code: D009676) Oxidants (Code: D016877) | |
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| etidronic acid | A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover. | antineoplastic agent (Code: CHEBI:35610) bone density conservation agent (Code: CHEBI:50646) Bisphosphonate (Code: N0000175579) Diphosphonates (Code: N0000007707) Bone Density Conservation Agents (Code: D050071) | 1977-09-01 FDA | 3SDV |
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| caroxazone | None | |
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| ciclopirox | trivalent metal (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21022s004lbl.pdf) | The mechanism of action of ciclopirox has been investigated using various in vitro and in vivo infection models. One in vitro study suggested that ciclopirox acts by chelation of polyvalent cations (Fe+3 or Al+3) resulting in the inhibition of the metal-dependent enzymes that are responsible for the degradation of peroxides within the fungal cell. The clinical significance of this observation is not known. | antiseborrheic (Code: CHEBI:59010) Decreased DNA Replication (Code: N0000008577) Decreased Protein Synthesis (Code: N0000008841) Decreased RNA Replication (Code: N0000008853) Protein Synthesis Inhibitors (Code: N0000000150) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1982-12-30 FDA | |
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| dexibuprofen | Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) None (Source: CHEMBL) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) None (Source: CHEMBL) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: CHEMBL) | None | non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | None EMA | 1EQG 2BXG 2PWS 2WD9 3IB2 3P6H 4JTR 4PH9 4RS0 5JQB |
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| pivhydrazine | None | |
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| pyrantel | Acetylcholinesterase (Organism: Meloidogyne incognita, class: Enzyme, accessions: O96529, gene: ACHE, swissprot: O96529_MELIC) | Broad spectrum anthelmintic for livestock. | antinematodal drug (Code: CHEBI:35444) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Depolarizing Agents (Code: D009467) Peripheral Nervous System Agents (Code: D018373) | 1974-01-01 YEAR INTRODUCED | |
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| miglitol | Maltase-glucoamylase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: O43451, gene: MGAM, swissprot: MGA_HUMAN) inhibitor (Source: CHEMBL) Glycogen debranching enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P35574, gene: AGL, swissprot: GDE_RABIT) None (Source: CHEMBL) Lactase-phlorizin hydrolase (Organism: Homo sapiens, class: Enzyme, accessions: P09848, gene: LCT, swissprot: LPH_HUMAN) None (Source: CHEMBL) Lysosomal alpha-glucosidase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q6P7A9, gene: Gaa, swissprot: LYAG_RAT) None (Source: CHEMBL) Sucrase-isomaltase, intestinal (Organism: Rattus norvegicus, class: Enzyme, accessions: P23739, gene: Si, swissprot: SUIS_RAT) None (Source: CHEMBL) Lysosomal alpha-glucosidase (Organism: Homo sapiens, class: Enzyme, accessions: P10253, gene: GAA, swissprot: LYAG_HUMAN) inhibitor (Source: CHEMBL) Glucosylceramidase (Organism: Homo sapiens, class: Enzyme, accessions: P04062, gene: GBA, swissprot: GLCM_HUMAN) None (Source: CHEMBL) Sucrase-isomaltase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: P14410, gene: SI, swissprot: SUIS_HUMAN) None (Source: CHEMBL) Pancreatic alpha-amylase (Organism: Homo sapiens, class: Enzyme, accessions: P04746, gene: AMY2A, swissprot: AMYP_HUMAN) Beta-galactosidase (Organism: Bos taurus, class: Unclassified, accessions: Q58D55, gene: GLB1, swissprot: BGAL_BOVIN) None (Source: CHEMBL) | Miglitol is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. | alpha Glucosidase Inhibitors (Code: N0000000166) alpha-Glucosidase Inhibitor (Code: N0000175559) Enzyme Inhibitors (Code: D004791) Glycoside Hydrolase Inhibitors (Code: D065089) Hypoglycemic Agents (Code: D007004) | 1996-12-18 FDA | 3L4W 5NN6 6CA1 6CA3 |
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| minoxidil | Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) opener (Source: http://www.ncbi.nlm.nih.gov/pubmed/18258787) ATP-sensitive inward rectifier potassium channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: P48048, gene: KCNJ1, swissprot: KCNJ1_HUMAN) | A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371) | vasodilator agent (Code: CHEBI:35620) antihypertensive agent (Code: CHEBI:35674) Arteriolar Vasodilation (Code: N0000175379) Arteriolar Vasodilator (Code: N0000175564) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1979-10-18 FDA | 3B6H 4K7A |
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| thurfyl nicotinate | None | |
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| toloxatone | Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: CHEMBL) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/1546145) Amine oxidase [flavin-containing] A (Organism: Bos taurus, class: Enzyme, accessions: P21398, gene: MAOA, swissprot: AOFA_BOVIN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Bos taurus, class: Enzyme, accessions: P56560, gene: MAOB, swissprot: AOFB_BOVIN) None (Source: CHEMBL) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) None (Source: CHEMBL) | oxazolidinone derivative; psychotropic drug; structure | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | |
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| guabenxan | combination of bemetizid diuretic & guabenxan antihypertensive agent | |
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| butacetin | None | |
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| meobentine | None | |
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| orciprenaline | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: CHEMBL) | A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM. | bronchodilator agent (Code: CHEBI:35523) beta-adrenergic agonist (Code: CHEBI:35522) anti-asthmatic drug (Code: CHEBI:49167) Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Tocolytic Agents (Code: D015149) | 1973-07-31 FDA | |
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| allobarbital | None | |
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| pilocarpine | Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24558448) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24558448) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24558448) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24558448) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24558448) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor DM1 (Organism: Drosophila melanogaster, class: GPCR, accessions: P16395, gene: mAChR-A, swissprot: ACM1_DROME) None (Source: CHEMBL) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: CHEMBL) Muscarinic acetylcholine receptor M1 (Organism: Mus musculus, class: GPCR, accessions: P12657, gene: Chrm1, swissprot: ACM1_MOUSE) None (Source: CHEMBL) | A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. | antiglaucoma drug (Code: CHEBI:39456) Cholinergic Muscarinic Agonists (Code: N0000000104) Cholinergic Receptor Agonist (Code: N0000175884) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Miotics (Code: D008916) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1974-07-29 FDA | 3T3Q 3T3R 3T3S 3T3Z |
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| chlormidazole | None | |
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| bendazol | has a hypotensive, vasodilator, antispasmodic action | 1964-04-30 Ministry of Health of the Russian Federation | |
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| oxyfenamate | None | 1961 YEAR INTRODUCED | |
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| isoprenaline | Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Beta-2 adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P04274, gene: ADRB2, swissprot: ADRB2_MESAU) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: CHEMBL) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) None (Source: CHEMBL) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) None (Source: CHEMBL) Beta-3 adrenergic receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P26255, gene: Adrb3, swissprot: ADRB3_RAT) agonist (Source: IUPHAR) | Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. | beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) cardiotonic drug (Code: CHEBI:38147) sympathomimetic agent (Code: CHEBI:35524) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) | 1956-03-09 FDA | 2Y03 4A7T |
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| proflavine | Topical antiseptic used mainly in wound dressings. | antiseptic drug (Code: CHEBI:48218) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | None FDA | 1BCU 1QVT 1QVU 1VTF 2V57 3FT6 3HTH 4ZPH |
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| fepradinol | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| bamethan | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| talipexole | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) None (Source: PDSP) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) None (Source: PDSP) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) None (Source: PDSP) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) None (Source: PDSP) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) None (Source: PDSP) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) None (Source: PDSP) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: PDSP) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) None (Source: CHEMBL) | dopamine receptor agonist; structure given in first source | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) | None PMDA | |
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| tolonidine | None | |
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| milrinone | Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) None (Source: CHEMBL) Cyclic nucleotide phosphodiesterase PDE3A (Organism: Sus scrofa, class: Enzyme, accessions: Q9XSW7, gene: None, swissprot: Q9XSW7_PIG) None (Source: CHEMBL) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) None (Source: CHEMBL) cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Organism: Homo sapiens, class: Enzyme, accessions: Q13370, gene: PDE3B, swissprot: PDE3B_HUMAN) None (Source: CHEMBL) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) inhibitor (Source: CHEMBL) Cyclic AMP-specific phosphodiesterase SSPDE4A1A (Organism: Sus scrofa, class: Enzyme, accessions: O77823, gene: PDE4A, swissprot: O77823_PIG) None (Source: CHEMBL) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Bos taurus, class: Enzyme, accessions: Q28156, gene: PDE5A, swissprot: PDE5A_BOVIN) None (Source: CHEMBL) Uncharacterized protein (Organism: Bos taurus, class: Enzyme, accessions: E1BN64, gene: PDE3B, swissprot: E1BN64_BOVIN) None (Source: CHEMBL) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Cavia porcellus, class: Enzyme, accessions: O89085, gene: PDE4A, swissprot: PDE4A_CAVPO) None (Source: CHEMBL) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) None (Source: CHEMBL) | A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone. | platelet aggregation inhibitor (Code: CHEBI:50427) vasodilator agent (Code: CHEBI:35620) cardiotonic drug (Code: CHEBI:38147) Phosphodiesterase 3 Inhibitor (Code: N0000175598) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Phosphodiesterase 3 Inhibitors (Code: D058987) Phosphodiesterase Inhibitors (Code: D010726) Platelet Aggregation Inhibitors (Code: D010975) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | 1987-12-31 FDA | 1TLM |
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| phanquinone | None | |
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| aprobarbital | None | |
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| naphazoline | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) agonist (Source: CHEMBL) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) agonist (Source: CHEMBL) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Adrenergic receptor alpha (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P19328|P22086|P22909|P23944|P43140, gene: Adra1a|Adra1b|Adra1d|Adra2a|Adra2b|Adra2c, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT|ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Nischarin (Organism: Rattus norvegicus, class: Unclassified, accessions: Q4G017, gene: Nisch, swissprot: NISCH_RAT) None (Source: CHEMBL) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) None (Source: CHEMBL) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: CHEMBL) | An adrenergic vasoconstrictor agent used as a decongestant. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Respiratory System Agents (Code: D019141) Vasoconstrictor Agents (Code: D014662) | 1971-06-07 FDA | |
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| xenbucin | None | |
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| altretamine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) other (Source: http://www.ncbi.nlm.nih.gov/pubmed/7763301) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) None (Source: DRUG MATRIX) | The precise mechanism by which altretamine capsules exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine capsules resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine capsules and its metabolites have been negative. Altretamine capsules has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement for cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1990-12-26 FDA | |
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| phosphocreatine | An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996) | Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Protective Agents (Code: D020011) | 2008-11-24 Ministry of Health of the Russian Federation | |
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| nicorandil | Atrial natriuretic peptide receptor 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16066, gene: NPR1, swissprot: ANPRA_HUMAN) ATP-sensitive inward rectifier potassium channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: P48048, gene: KCNJ1, swissprot: KCNJ1_HUMAN) ATP-sensitive inward rectifier potassium channel 11 (Organism: Homo sapiens, class: Ion channel, accessions: Q14654, gene: KCNJ11, swissprot: KCJ11_HUMAN) | A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase. | vasodilator agent (Code: CHEBI:35620) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vasodilator Agents (Code: D014665) Vitamin B Complex (Code: D014803) | 1984-01-01 YEAR INTRODUCED | |
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| methyldopa | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: DRUG MATRIX) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Source: CHEMBL) Aromatic-L-amino-acid decarboxylase (Organism: Homo sapiens, class: Enzyme, accessions: P20711, gene: DDC, swissprot: DDC_HUMAN) Lysine-specific demethylase 4E (Organism: Homo sapiens, class: Enzyme, accessions: B2RXH2, gene: KDM4E, swissprot: KDM4E_HUMAN) None (Source: CHEMBL) | An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. | sympatholytic agent (Code: CHEBI:66991) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic agonist (Code: CHEBI:35569) peripheral nervous system drug (Code: CHEBI:49110) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1962-12-20 FDA | |
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| melevodopa | None | Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) | 1993-07-09 FDA | |
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| zalcitabine | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) inhibitor (Source: CHEMBL) Deoxycytidine kinase (Organism: Homo sapiens, class: Kinase, accessions: P27707, gene: DCK, swissprot: DCK_HUMAN) | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. | antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1992-06-19 FDA | |
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| levisoprenaline | None | sympathomimetic agent (Code: CHEBI:35524) beta-adrenergic agonist (Code: CHEBI:35522) | 2Y03 4A7T |
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| methoxamine | Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) agonist (Source: CHEMBL) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Source: CHEMBL) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: CHEMBL) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: CHEMBL) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) None (Source: IUPHAR) | An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION. | antihypotensive agent (Code: CHEBI:137431) alpha-adrenergic agonist (Code: CHEBI:35569) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | None FDA | |
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| dioxethedrin | None | |
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| varenicline | Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) agonist (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: CHEMBL) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12392, gene: Chrna2|Chrnb4, swissprot: ACHA2_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: CHEMBL) Acetylcholine receptor (Organism: Torpedo californica, class: Ion channel, accessions: P02710|P02712|P02714|P02718, gene: CHRNA1|CHRNB1|CHRNG|chrnd, swissprot: ACHA_TORCA|ACHB_TORCA|ACHD_TORCA|ACHG_TORCA) None (Source: CHEMBL) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) None (Source: CHEMBL) | A benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION. | nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) serotonergic agonist (Code: CHEBI:35941) Partial Cholinergic Nicotinic Agonist (Code: N0000175705) Partial Cholinergic Nicotinic Agonists (Code: N0000175702) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Neurotransmitter Agents (Code: D018377) Nicotinic Agonists (Code: D018722) | 2006-05-10 FDA | 4AFG 4AFT 5AIN |
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| pramipexole | D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) None (Source: CHEMBL) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) agonist (Source: CHEMBL) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) None (Source: CHEMBL) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) None (Source: CHEMBL) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: CHEMBL) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) None (Source: PDSP) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) None (Source: PDSP) | A dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity. Pramipexole alleviates parkinsonian motor deficits by stimulation of dopamine receptors in the striatum. Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover. | antiparkinson drug (Code: CHEBI:48407) dopamine agonist (Code: CHEBI:51065) antidyskinesia agent (Code: CHEBI:66956) Nonergot Dopamine Agonist (Code: N0000175768) Anti-Dyskinesia Agents (Code: D018726) Antioxidants (Code: D000975) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1997-07-01 FDA | |
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| chlorthenoxazine | Poly [ADP-ribose] polymerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P09874, gene: PARP1, swissprot: PARP1_HUMAN) None (Source: CHEMBL) | None | |
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| kainic acid | Glutamate receptor ionotropic, kainate 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q16099, gene: GRIK4, swissprot: GRIK4_HUMAN) None (Source: PDSP) Glutamate receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P42261, gene: GRIA1, swissprot: GRIA1_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, AMPA (Organism: Rattus norvegicus, class: Ion channel, accessions: P19490|P19491|P19492|P19493, gene: Gria1|Gria2|Gria3|Gria4, swissprot: GRIA1_RAT|GRIA2_RAT|GRIA3_RAT|GRIA4_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P22756, gene: Grik1, swissprot: GRIK1_RAT) None (Source: CHEMBL) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: CHEMBL) Glutamate receptor 4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19493, gene: Gria4, swissprot: GRIA4_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate (Organism: Rattus norvegicus, class: Ion channel, accessions: P22756|P42260|P42264|Q01812|Q63273, gene: Grik1|Grik2|Grik3|Grik4|Grik5, swissprot: GRIK1_RAT|GRIK2_RAT|GRIK3_RAT|GRIK4_RAT|GRIK5_RAT) None (Source: CHEMBL) Glutamate receptor 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19492, gene: Gria3, swissprot: GRIA3_RAT) None (Source: CHEMBL) Glutamate receptor 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19490, gene: Gria1, swissprot: GRIA1_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P42264, gene: Grik3, swissprot: GRIK3_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q16478, gene: GRIK5, swissprot: GRIK5_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 4 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q01812, gene: Grik4, swissprot: GRIK4_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 5 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q63273, gene: Grik5, swissprot: GRIK5_RAT) None (Source: CHEMBL) Glutamate receptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: P48058, gene: GRIA4, swissprot: GRIA4_HUMAN) None (Source: CHEMBL) Glutamate receptor 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19491, gene: Gria2, swissprot: GRIA2_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P42260, gene: Grik2, swissprot: GRIK2_RAT) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q13002, gene: GRIK2, swissprot: GRIK2_HUMAN) None (Source: CHEMBL) Glutamate receptor 2 (Organism: Homo sapiens, class: Ion channel, accessions: P42262, gene: GRIA2, swissprot: GRIA2_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 1 (Organism: Homo sapiens, class: Ion channel, accessions: P39086, gene: GRIK1, swissprot: GRIK1_HUMAN) None (Source: CHEMBL) Glutamate receptor ionotropic, kainate 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q13003, gene: GRIK3, swissprot: GRIK3_HUMAN) None (Source: CHEMBL) Glutamate receptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P42263, gene: GRIA3, swissprot: GRIA3_HUMAN) None (Source: PDSP) | (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose. | antinematodal drug (Code: CHEBI:35444) excitatory amino acid agonist (Code: CHEBI:50103) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Agonists (Code: D018690) Neurotransmitter Agents (Code: D018377) | 1FTK 1FW0 1GR2 1LBB 1P1N 1TT1 1XHY 2ANJ 2XXT 2XXV 2XXY 3C31 3C32 3C33 3C34 3C35 3C36 3EN3 3KFM 3T9H 3U92 4BDM 4BDO 4BDR 4E0W 4E0X 4F22 4F31 4F39 4F3G 4U1O 4U1W 4U1X 4U1Z 4U2Q 4U5B 4U5D 4U5E 4U5F 5IKB 5MFQ 5MFV 5MFW |
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| mefenorex | None | Autonomic Agents (Code: D001337) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | |
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| zonisamide | Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Carbonic anhydrase V (Organism: Homo sapiens, class: Enzyme, accessions: P35218|Q9Y2D0, gene: CA5A|CA5B, swissprot: CAH5A_HUMAN|CAH5B_HUMAN) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 3 (Organism: Bos taurus, class: Enzyme, accessions: Q3SZX4, gene: CA3, swissprot: CAH3_BOVIN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Amine oxidase [flavin-containing] (Organism: Danio rerio, class: Unclassified, accessions: Q6NSN2, gene: mao, swissprot: AOF_DANRE) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents, blocks sodium channels and reduces voltage-dependent, transient inward currents (T-type Ca2+ currents), consequently stabilizing neuronal membranes and suppressing neuronal hypersynchronization | anticonvulsant (Code: CHEBI:35623) central nervous system drug (Code: CHEBI:35470) protective agent (Code: CHEBI:50267) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Antioxidants (Code: D000975) Central Nervous System Agents (Code: D002491) Sulfonamides (Code: N0000008048) Carbonic Anhydrase Inhibitors (Code: N0000000235) P-Glycoprotein Inhibitors (Code: N0000185503) Protective Agents (Code: D020011) | 2000-03-27 FDA | 3PO7 |
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| felbinac | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | an anti-inflammatory/analgesic agent which has been developed into a topical gel for local treatment and pain and inflammation associated with conditions of the musculo-skeletal system | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 1MHW |
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| benzyl benzoate | Hormone-sensitive lipase (Organism: Rattus norvegicus, class: Enzyme, accessions: P15304, gene: Lipe, swissprot: LIPS_RAT) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) | None | scabicide (Code: CHEBI:73333) acaricide (Code: CHEBI:22153) Insecticides (Code: D007306) Pesticides (Code: D010575) | 1976-09-02 FDA | 1DZM |
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| butobarbital | Butobarbital should be distinguished from Butabarbital (a synonym for Secbutabarbital) | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| secbutabarbital | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | Butabarbital (a synonym for Secbutabarbital) should be distinguished from Butobarbital | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1939-06-05 FDA | |
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| albutoin | None | |
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| inaperisone | None | |
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| troxacitabine | None | Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) | 2NO9 |
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| salicylanilide | None | 3AE2 |
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| benzyl nicotinate | None | vasodilator agent (Code: CHEBI:35620) | 4EH5 |
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| phenazopyridine | Snake venom metalloproteinase Bap1 (Organism: Bothrops asper, class: Unclassified, accessions: P83512, gene: None, swissprot: VM1B1_BOTAS) Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) | A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. | local anaesthetic (Code: CHEBI:36333) non-narcotic analgesic (Code: CHEBI:35481) | 2001-06-26 FDA | |
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| ketamine | Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) Glutamate receptor ionotropic AMPA (Organism: Homo sapiens, class: Ion channel, accessions: P42261|P42262|P42263|P48058, gene: GRIA1|GRIA2|GRIA3|GRIA4, swissprot: GRIA1_HUMAN|GRIA2_HUMAN|GRIA3_HUMAN|GRIA4_HUMAN) | A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors. | General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Analgesics (Code: D000700) Anesthetics (Code: D000777) Anesthetics, Dissociative (Code: D000778) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) intravenous anaesthetic (Code: CHEBI:38877) analgesic (Code: CHEBI:35480) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1970-02-19 FDA | 4F8H |
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| guanadrel | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) | None | antihypertensive agent (Code: CHEBI:35674) adrenergic antagonist (Code: CHEBI:37887) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | 1982-12-29 FDA | |
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| baclofen | Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) GABA-B receptor (Organism: Homo sapiens, class: GPCR, accessions: O75899|Q9UBS5, gene: GABBR1|GABBR2, swissprot: GABR1_HUMAN|GABR2_HUMAN) GABA B receptor (Organism: Rattus norvegicus, class: GPCR, accessions: O88871|Q9Z0U4, gene: Gabbr1|Gabbr2, swissprot: GABR1_RAT|GABR2_RAT) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) | A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission. | muscle relaxant (Code: CHEBI:51371) central nervous system depressant (Code: CHEBI:35488) GABA agonist (Code: CHEBI:51373) GABA A Agonists (Code: N0000000196) GABA B Agonists (Code: N0000000116) gamma-Aminobutyric Acid-ergic Agonist (Code: N0000175759) Central Nervous System Agents (Code: D002491) GABA Agents (Code: D018682) GABA Agonists (Code: D018755) GABA-B Receptor Agonists (Code: D058786) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1977-11-22 FDA | 4MS4 |
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| clorprenaline | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | None | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) | |
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| chloroxine | Botulinum neurotoxin type A (Organism: Clostridium botulinum, class: Enzyme, accessions: P10845, gene: botA, swissprot: BXA1_CLOBO) Arachidonate 12-lipoxygenase, 12S-type (Organism: Homo sapiens, class: Enzyme, accessions: P18054, gene: ALOX12, swissprot: LOX12_HUMAN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Arachidonate 15-lipoxygenase, type II (Organism: Homo sapiens, class: Enzyme, accessions: O15296, gene: ALOX15B, swissprot: LX15B_HUMAN) Arachidonate 15-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P16050, gene: ALOX15, swissprot: LOX15_HUMAN) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1976-10-19 FDA | |
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| cinametic acid | used in liver function tests; relaxes sphincter of Oddi; regulates hepato-biliary function; structure | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) | |
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| carmustine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed) | antineoplastic agent (Code: CHEBI:35610) Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1977-03-07 FDA | |
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| niridazole | An antischistosomal agent that has become obsolete. | Amebicides (Code: D000563) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Antiprotozoal Agents (Code: D000981) Schistosomicides (Code: D012556) | |
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| phenyl salicylate | None | None FDA | |
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| amifostine | reactive chemical species (Organism: None, class: Reactive chemical species, accessions: None, gene: None, swissprot: None) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Homo sapiens, class: Enzyme, accessions: P05186, gene: ALPL, swissprot: PPBT_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | prodrug (Code: CHEBI:50266) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) | 1995-12-08 FDA | |
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| salbutamol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol. | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Respiratory System Agents (Code: D019141) Tocolytic Agents (Code: D015149) | 1981-05-01 FDA | 2Y04 |
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| sulfacetamide | Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Dihydrofolate reductase (Organism: Bos taurus, class: Unclassified, accessions: P00376, gene: DHFR, swissprot: DYR_BOVIN) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. | antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) Sulfonamide Antibacterial (Code: N0000175503) Sulfonamides (Code: N0000008048) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | 1945-09-12 FDA | |
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| sulfaguanidine | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Trypsin (Organism: Homo sapiens, class: Enzyme, accessions: P07477|P07478|P35030, gene: PRSS1|PRSS2|PRSS3, swissprot: TRY1_HUMAN|TRY2_HUMAN|TRY3_HUMAN) | A sulfanilamide antimicrobial agent that is used to treat enteric infections. | Anti-Infective Agents (Code: D000890) | |
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| velnacrine | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) | None | Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) | |
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| fenyramidol | considered as a drug that possibly causes hepatotoxicity | |
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| clofibric acid | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Mus musculus, class: Transcription factor, accessions: P23204, gene: Ppara, swissprot: PPARA_MOUSE) Lipoprotein lipase (Organism: Homo sapiens, class: Enzyme, accessions: P06858, gene: LPL, swissprot: LIPL_HUMAN) | An antilipemic agent that is the biologically active metabolite of CLOFIBRATE. | anticholesteremic drug (Code: CHEBI:35821) antilipemic drug (Code: CHEBI:35679) antineoplastic agent (Code: CHEBI:35610) herbicide (Code: CHEBI:24527) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 1963-01-01 YEAR INTRODUCED | |
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| phenaglycodol | None | |
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| glutethimide | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A hypnotic and sedative. Its use has been largely superseded by other drugs. | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1976-10-28 FDA | |
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| naftazone | None | Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) | |
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| ciclobendazole | None | |
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| kinetin | Endochitinase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P29029, gene: CTS1, swissprot: CHIT_YEAST) | A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects. | Growth Substances (Code: D006133) Plant Growth Regulators (Code: D010937) | None FDA | 2UY5 3O5W 3T4S 4A85 4A86 4JHH 4JKX |
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| sulfacarbamide | antimicrobial agent; structure | |
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| 5-aminolevulinic acid hexyl ester | None | 2010-05-28 FDA | |
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| ibuproxam | Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| nadoxolol | None | |
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| tramazoline | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) | None | Autonomic Agents (Code: D001337) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | |
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| butoctamide | stimulates serotonin release from rat peritoneal mast cells | |
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| fencamfamin | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Central Nervous System Stimulants (Code: D000697) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| tiamenidine | Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) | None | |
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| cicletanine | None | Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| bergapten | Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63470, gene: Dyrk1a, swissprot: DYR1A_RAT) | a linear furanocoumarin with phototoxic effects similar to METHOXSALEN which is 8-methoxypsoralen | hepatoprotective agent (Code: CHEBI:62868) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) | |
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| methoxsalen | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation. | dermatologic drug (Code: CHEBI:50177) antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) cross-linking reagent (Code: CHEBI:50684) Photoabsorption (Code: N0000010217) Photoactivated Radical Generator (Code: N0000175984) Photosensitizing Activity (Code: N0000009801) Psoralen (Code: N0000175879) Psoralens (Code: N0000007909) Cross-Linking Reagents (Code: D003432) Dermatologic Agents (Code: D003879) Indicators and Reagents (Code: D007202) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) | 1954-12-03 FDA | 1Z11 |
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| bisorcic | None | |
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| arsanilic acid | An arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. | 1N4F |
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| fosfosal | reagent for testing the activity of certain enzymes | |
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| tetrabarbital | None | |
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| captopril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Beta-lactamase (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q79MP6, gene: blaIMP-1, swissprot: Q79MP6_PSEAI) Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Leukotriene A-4 hydrolase (Organism: Homo sapiens, class: Enzyme, accessions: P09960, gene: LTA4H, swissprot: LKHA4_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Angiotensin-converting enzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P47820, gene: Ace, swissprot: ACE_RAT) Renin (Organism: Homo sapiens, class: Enzyme, accessions: P00797, gene: REN, swissprot: RENI_HUMAN) Succinyl-diaminopimelate desuccinylase (Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), class: Enzyme, accessions: P44514, gene: dapE, swissprot: DAPE_HAEIN) Beta-lactamase II (Organism: Bacillus anthracis, class: Unclassified, accessions: Q93T40, gene: bla2, swissprot: Q93T40_BACAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Beta-lactamase class B VIM-2 (Organism: Pseudomonas aeruginosa, class: Unclassified, accessions: Q9K2N0, gene: blaVIM-2, swissprot: Q9K2N0_PSEAI) | A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. | EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) antihypertensive agent (Code: CHEBI:35674) Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1981-04-06 FDA | 1J37 2X8Z 3LUS 4C1D 4C1F 4C1H 4C2P 4DPR 4EXS 4PQA 5AYA |
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| tinazoline | None | |
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| prolintane | None | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) | |
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| salicylsulfuric acid | None | |
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| triacetin | A triglyceride that is used as an antifungal agent. | solvent (Code: CHEBI:46787) adjuvant (Code: CHEBI:60809) antifungal drug (Code: CHEBI:86327) food additive carrier (Code: CHEBI:78059) food emulsifier (Code: CHEBI:63047) food humectant (Code: CHEBI:77969) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Solvents (Code: D012997) | |
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| heptobarbital | None | |
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| meprobamate | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) | Anti-Anxiety Agents (Code: D014151) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1955-04-28 FDA | |
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| primidone | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | An antiepileptic agent related to the barbiturates; it is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with phenobarbital. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309) | anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1954-03-08 FDA | |
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| mephenytoin | Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) | An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias. | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1946-10-23 FDA | |
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| levocarnitine propionate | None | |
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| aclatonium | Muscarinic acetylcholine receptor (Organism: Homo sapiens, class: GPCR, accessions: P08172|P08173|P08912|P11229|P20309, gene: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5, swissprot: ACM1_HUMAN|ACM2_HUMAN|ACM3_HUMAN|ACM4_HUMAN|ACM5_HUMAN) | None | |
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| benzylthiouracil | None | |
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| malotilate | None | None PMDA | |
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| fenoxazoline | Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) | None | |
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| uredepa | None | |
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| calcium pantothenate | A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE. | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vitamin B Complex (Code: D014803) | 1993-12-29 FDA | 1SQ5 2F9W 2ZS9 2ZSE 3AF0 3AF3 3AVO 3BEX 3BF1 3UY4 4O5F 5B8H 5E26 5KPR |
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| aniracetam | mental performance enhancer; RN given refers to cpd with locant for methoxy group in position 4 & from USAN 1983 | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Nootropic Agents (Code: D018697) Psychotropic Drugs (Code: D011619) | 2AL5 3LSW |
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| dacisteine | None | |
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| pirbuterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | None | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Respiratory System Agents (Code: D019141) | 1986-12-30 FDA | |
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| miglustat | Ceramide glucosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q16739, gene: UGCG, swissprot: CEGT_HUMAN) Maltase-glucoamylase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: O43451, gene: MGAM, swissprot: MGA_HUMAN) Glycogen debranching enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P35573, gene: AGL, swissprot: GDE_HUMAN) Lysosomal alpha-glucosidase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q6P7A9, gene: Gaa, swissprot: LYAG_RAT) Trehalase (Organism: Rattus norvegicus, class: Unclassified, accessions: O70282, gene: Treh, swissprot: O70282_RAT) Uncharacterized protein (Organism: Sus scrofa, class: Unclassified, accessions: I3LIR5, gene: TREH, swissprot: I3LIR5_PIG) Sucrase-isomaltase, intestinal (Organism: Rattus norvegicus, class: Enzyme, accessions: P23739, gene: Si, swissprot: SUIS_RAT) Non-lysosomal glucosylceramidase (Organism: Mus musculus, class: Enzyme, accessions: Q69ZF3, gene: Gba2, swissprot: GBA2_MOUSE) Putative alpha-glucosidase (Organism: Oryza sativa subsp. japonica, class: Enzyme, accessions: Q9LGC6, gene: P0504H10.9, swissprot: Q9LGC6_ORYSJ) Lysosomal alpha-glucosidase (Organism: Homo sapiens, class: Enzyme, accessions: P10253, gene: GAA, swissprot: LYAG_HUMAN) Sucrase-isomaltase (Organism: Mus musculus, class: Enzyme, accessions: B5THE3, gene: Sis, swissprot: B5THE3_MOUSE) Non-lysosomal glucosylceramidase (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCG7, gene: GBA2, swissprot: GBA2_HUMAN) Lysosomal alpha-glucosidase (Organism: Mus musculus, class: Enzyme, accessions: P70699, gene: Gaa, swissprot: LYAG_MOUSE) Ceramide glucosyltransferase (Organism: Mus musculus, class: Unclassified, accessions: O88693, gene: Ugcg, swissprot: CEGT_MOUSE) Sucrase-isomaltase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: P14410, gene: SI, swissprot: SUIS_HUMAN) | Miglustat functions as a competitive and reversible inhibitor of the enzyme glucosylceramide synthase, the initial enzyme in a series of reactions which results in the synthesis of most glycosphingolipids. Miglustat helps reduce the rate of glycosphingolipid biosynthesis so that the amount of glycosphingolipid substrate is reduced to a level which allows the residual activity of the deficient glucocerebrosidase enzyme to be more effective (substrate reduction therapy). In vitro and in vivo studies have shown that miglustat can reduce the synthesis of glucosylceramide-based glycosphingolipids. | Glucosylceramide Synthase Inhibitor (Code: N0000175783) Glucosylceramide Synthase Inhibitors (Code: N0000020019) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Glycoside Hydrolase Inhibitors (Code: D065089) Hypoglycemic Agents (Code: D007004) | 2002-11-20 EMA 2003-07-31 FDA | 2V3D 5IEF |
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| alminoprofen | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antirheumatic drug (Code: CHEBI:35842) antipyretic (Code: CHEBI:35493) non-narcotic analgesic (Code: CHEBI:35481) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| carbidopa | Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Lysine-specific demethylase 4E (Organism: Homo sapiens, class: Enzyme, accessions: B2RXH2, gene: KDM4E, swissprot: KDM4E_HUMAN) Aromatic-L-amino-acid decarboxylase (Organism: Homo sapiens, class: Enzyme, accessions: P20711, gene: DDC, swissprot: DDC_HUMAN) | An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no antiparkinson actions by itself. | antidyskinesia agent (Code: CHEBI:66956) antiparkinson drug (Code: CHEBI:48407) dopaminergic agent (Code: CHEBI:48560) Aromatic Amino Acid Decarboxylation Inhibitor (Code: N0000175754) DOPA Decarboxylase Inhibitors (Code: N0000175755) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Aromatic Amino Acid Decarboxylase Inhibitors (Code: D065105) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) | 1975-05-02 FDA | 1JS3 |
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| ornidazole | A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action. | antiprotozoal drug (Code: CHEBI:35820) antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) antitrichomonal drug (Code: CHEBI:50685) Amebicides (Code: D000563) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antitrichomonal Agents (Code: D000994) Radiation-Sensitizing Agents (Code: D011838) | |
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| oxitriptan | 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | 5-HTP (5-Hydroxytryptophan) is a chemical by-product of the protein building block L-tryptophan. It is also produced commercially from the seeds of an African plant known as Griffonia simplicifolia 5-HTP is used for sleep disorders such as insomnia, depression, anxiety, migraine and tension-type headaches, fibromyalgia, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), seizure disorder, and Parkinson's disease. | Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | 5KPY |
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| cycloxilic acid | None | |
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| fadrozole | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN) Cytochrome P450 11B2, mitochondrial (Organism: Mus musculus, class: Unclassified, accessions: P15539, gene: Cyp11b2, swissprot: C11B2_MOUSE) | A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer. | Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 4FDH |
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| lidamidine | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Antidiarrheals (Code: D000930) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) | |
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| butibufen | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| prilocaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry. | anticonvulsant (Code: CHEBI:35623) local anaesthetic (Code: CHEBI:36333) Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1965-11-18 FDA | |
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| metaxalone | muscle spasm relaxant; structure | Centrally-mediated Muscle Relaxation (Code: N0000175730) Muscle Relaxant (Code: N0000175737) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | 1962-08-13 FDA | |
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| phenamacide | None | |
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| exalamide | None | |
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| procarbazine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | antineoplastic agent (Code: CHEBI:35610) Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Antineoplastic Agents (Code: D000970) | 1969-07-22 FDA | |
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| mecloralurea | None | |
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| chlorazanil | None | |
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| methiodal | major descriptor (66-86); on-line search METHANESULFONATES (74-86), ALKYL SULFONATES (73), SULFONIC ACIDS (66-72); INDEX MEDICUS search METHIODAL (66-86) | |
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| dimecrotic acid | None | |
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| phenindione | Vitamin K epoxide reductase complex subunit 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BQB6, gene: VKORC1, swissprot: VKOR1_HUMAN) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) | An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234) | anticoagulant (Code: CHEBI:50249) Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | None FDA | |
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| morinamide | None | |
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| acetazolamide | Carbonic anhydrase 1; GH09688p (Organism: Drosophila melanogaster, class: Enzyme, accessions: Q9V396, gene: CAH1, swissprot: Q9V396_DROME) Carbonic anhydrase 2, isoform A; LD26647p (Organism: Drosophila melanogaster, class: Enzyme, accessions: Q9VTU8, gene: CAH2, swissprot: Q9VTU8_DROME) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Homo sapiens, class: Enzyme, accessions: O43570|P00915|P00918|P07451|P22748|P23280|P35218|P43166|Q16790|Q8N1Q1|Q9ULX7|Q9Y2D0, gene: CA1|CA12|CA13|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA9, swissprot: CAH12_HUMAN|CAH13_HUMAN|CAH14_HUMAN|CAH1_HUMAN|CAH2_HUMAN|CAH3_HUMAN|CAH4_HUMAN|CAH5A_HUMAN|CAH5B_HUMAN|CAH6_HUMAN|CAH7_HUMAN|CAH9_HUMAN) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase (Organism: Dicentrarchus labrax, class: Unclassified, accessions: Q2PCB5, gene: ca, swissprot: Q2PCB5_DICLA) Carbonic anhydrase 2 (Organism: Bos taurus, class: Enzyme, accessions: P00921, gene: CA2, swissprot: CAH2_BOVIN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Carbonic anhydrase V (Organism: Homo sapiens, class: Enzyme, accessions: P35218|Q9Y2D0, gene: CA5A|CA5B, swissprot: CAH5A_HUMAN|CAH5B_HUMAN) Carbonic anhydrase 7 (Organism: Mus musculus, class: Enzyme, accessions: Q9ERQ8, gene: Ca7, swissprot: CAH7_MOUSE) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Carbonic anhydrase (Organism: Bos taurus, class: Enzyme, accessions: P00921|P18915|Q3SZX4|Q95323, gene: CA2|CA3|CA4|CA6, swissprot: CAH2_BOVIN|CAH3_BOVIN|CAH4_BOVIN|CAH6_BOVIN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Endochitinase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P29029, gene: CTS1, swissprot: CHIT_YEAST) Carbonic anhydrase 3 (Organism: Bos taurus, class: Enzyme, accessions: Q3SZX4, gene: CA3, swissprot: CAH3_BOVIN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase (Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65), class: Enzyme, accessions: Q6FTL6, gene: None, swissprot: Q6FTL6_CANGA) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Carbonic anhydrase (Organism: Flaveria bidentis, class: Enzyme, accessions: P46510, gene: None, swissprot: CAHX_FLABI) Aquaporin-1 (Organism: Homo sapiens, class: Unclassified, accessions: P29972, gene: AQP1, swissprot: AQP1_HUMAN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) Carbonic anhydrase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1), class: Unclassified, accessions: Q9HVB9, gene: None, swissprot: Q9HVB9_PSEAE) | One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) | Carbonic Anhydrase Inhibitor (Code: N0000175517) Sulfonamides (Code: N0000008048) Anticonvulsants (Code: D000927) Carbonic Anhydrase Inhibitors (Code: D002257) Central Nervous System Agents (Code: D002491) Diuretics (Code: D004232) Enzyme Inhibitors (Code: D004791) Natriuretic Agents (Code: D045283) | 1953-07-27 FDA | 1AZM 1DMY 1JD0 1RJ6 1YDA 1YDB 1YDD 1ZSB 2H4N 2UY4 2XTK 3CZV 3DC3 3HS4 3IAI 3ML5 3UCJ 3V2J 3V2M 3W6H 4G7A 4K0S 4LU3 4UOV 4X5S 4XIW 4YGF 5JN8 5NEK |
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| nimorazole | An antitrichomonal agent which is effective either topically or orally and whose urinary metabolites are also trichomonicidal. | Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antitrichomonal Agents (Code: D000994) | |
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| nicametate | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| bromisoval | A sedative and mild hypnotic with potentially toxic effects. | sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| mephenoxalone | minor descriptor (65-86); on-line & INDEX MEDICUS search OXAZOLES (66-86) | |
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| nifenalol | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) | adrenergic beta-blocker with good antiarrhythmic properties; also tends to lower blood pressure & provide protection against angina; minor descriptor (75-86); on-line & INDEX MEDICUS search ETHANOLAMINES (75-86); RN given refers to parent cpd without isomeric designation | |
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| pentobarbital | Gamma-aminobutyric acid receptor subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472, gene: GABRB3, swissprot: GBRB3_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) | GABAA receptor agonist (Code: CHEBI:91016) Adjuvants, Anesthesia (Code: D000759) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | 1973-09-19 FDA | 3RAV |
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| bufexamac | Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) M1-family alanyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8IEK1, gene: None, swissprot: Q8IEK1_PLAF7) | A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally. | non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 5BPP |
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| rimiterol | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Neurotransmitter Agents (Code: D018377) | |
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| etamivan | minor descriptor (65-72); major descriptor (73-86); on-line search BENZAMIDES (66-86); INDEX MEDICUS search BENZAMIDES (65-72); ETHAMIVAN (73-86) | 2XDL |
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| cerulenin | Fatty acid synthase (Organism: Homo sapiens, class: Enzyme, accessions: P49327, gene: FASN, swissprot: FAS_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Coagulation factor XIII A chain (Organism: Homo sapiens, class: Enzyme, accessions: P00488, gene: F13A1, swissprot: F13A_HUMAN) | An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function. | antiinfective agent (Code: CHEBI:35441) antilipemic drug (Code: CHEBI:35679) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antimetabolites (Code: D000963) Fatty Acid Synthesis Inhibitors (Code: D054872) Hypolipidemic Agents (Code: D000960) | 4LS7 |
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| benmoxin | None | |
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| bucetin | None | |
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| neostigmine | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) | A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier. | Cholinesterase Inhibitor (Code: N0000175723) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 2013-05-31 FDA | |
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| toliprolol | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris | |
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| tigloidine | None | |
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| bucillamine | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antioxidants (Code: D000975) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sensory System Agents (Code: D018689) | |
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| ciramadol | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | benzylamine analgesics; structure given in fourth source | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| vinylbital | None | |
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| nifuradene | None | |
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| stavudine | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) | A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175462) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1994-06-24 FDA | |
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| etofylline | Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) | etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin) | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| vinbarbital | None | |
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| enallylpropymal | None | |
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| butalbital | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | management of butalbital withdrawal can be simplified by using a phenobarbital-loading protocol; RN given refers to parent cpd | sedative (Code: CHEBI:35717) analgesic (Code: CHEBI:35480) Barbiturate (Code: N0000175693) Barbiturates (Code: N0000008016) | 1976-05-04 FDA | |
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| febuprol | None | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) | |
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| furazolidone | A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514) | antitrichomonal drug (Code: CHEBI:50685) antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Anti-Infective Agents, Urinary (Code: D000892) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antitrichomonal Agents (Code: D000994) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Renal Agents (Code: D012076) | 1958-01-20 FDA | |
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| ancitabine | Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action. | prodrug (Code: CHEBI:50266) antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | |
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| aciclovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) DNA polymerase catalytic subunit (Organism: Varicella-zoster virus (strain Dumas), class: Enzyme, accessions: P09252, gene: None, swissprot: DPOL_VZVD) Thymidine kinase (Organism: Human herpesvirus 1, class: Kinase, accessions: Q9QNF7, gene: TK, swissprot: KITH_HHV1) Thymidine kinase (Organism: Human herpesvirus 2 (strain 333), class: Kinase, accessions: P04407, gene: TK, swissprot: KITH_HHV23) Thymidine kinase (Organism: Varicella-zoster virus (strain Dumas), class: Kinase, accessions: P09250, gene: None, swissprot: KITH_VZVD) Purine nucleoside phosphorylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WP01, gene: punA, swissprot: PUNA_MYCTU) | A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes. | antiviral drug (Code: CHEBI:36044) DNA Polymerase Inhibitors (Code: N0000020060) Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000180187) Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000180188) Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000175468) Nucleoside Analog (Code: N0000175459) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1982-03-29 FDA | 1PWY 2KI5 3MJR 4DA7 5I3C |
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| mephenesin carbamate | None | |
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| drometrizole | None | |
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| amobarbital | A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565) | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | None FDA | |
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| terbutaline | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. | hypoglycemic agent (Code: CHEBI:35526) beta-adrenergic agonist (Code: CHEBI:35522) anti-asthmatic drug (Code: CHEBI:49167) bronchodilator agent (Code: CHEBI:35523) sympathomimetic agent (Code: CHEBI:35524) tocolytic agent (Code: CHEBI:66993) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Tocolytic Agents (Code: D015149) | 1974-03-25 FDA | |
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| prenalterol | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | A partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute CARDIAC FAILURE, postmyocardial infarction low-output syndrome, SHOCK, and reducing ORTHOSTATIC HYPOTENSION in the SHY-RAGER SYNDROME. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-1 Receptor Agonists (Code: D058665) Adrenergic beta-Agonists (Code: D000318) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sympathomimetics (Code: D013566) | 1980-01-01 YEAR INTRODUCED | |
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| lefetamine | None | |
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| dithranol | 5-lipoxygenase (Organism: Bos taurus, class: Enzyme, accessions: Q9BEG3, gene: None, swissprot: Q9BEG3_BOVIN) Arachidonate 12-lipoxygenase, 12R-type (Organism: Homo sapiens, class: Enzyme, accessions: O75342, gene: ALOX12B, swissprot: LX12B_HUMAN) | An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS. | antipsoriatic (Code: CHEBI:50748) Dermatologic Agents (Code: D003879) | None FDA | |
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| proxibarbal | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| methallatal | None | |
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| crotetamide | same pharmacological action as prethcamide; component of prethcamide; structure | |
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| clopirac | None | |
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| pirlindole | Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) | None | Antidepressive Agents (Code: D000928) Antineoplastic Agents (Code: D000970) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | |
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| alclofenac | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1969-01-01 YEAR INTRODUCED | |
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| methocarbamol | Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) | A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206) | Centrally-mediated Muscle Relaxation (Code: N0000175730) muscle relaxant (Code: CHEBI:51371) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | 1957-07-16 FDA | |
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| glyceryl trinitrate | Soluble guanylate cyclase (Organism: Homo sapiens, class: Enzyme, accessions: O75343|P33402|Q02108|Q02153, gene: GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3, swissprot: GCYA2_HUMAN|GCYA3_HUMAN|GCYB1_HUMAN|GCYB2_HUMAN) Atrial natriuretic peptide receptor 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16066, gene: NPR1, swissprot: ANPRA_HUMAN) | A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. | vasodilator agent (Code: CHEBI:35620) tocolytic agent (Code: CHEBI:66993) muscle relaxant (Code: CHEBI:51371) prodrug (Code: CHEBI:50266) Nitrate Vasodilator (Code: N0000175415) Nitrates (Code: N0000007647) Vasodilation (Code: N0000009909) Cardiovascular Agents (Code: D002317) Explosive Agents (Code: D053834) Vasodilator Agents (Code: D014665) | 1981-05-28 FDA | 4FR8 |
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| decitabine | DNA (cytosine-5)-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P26358, gene: DNMT1, swissprot: DNMT1_HUMAN) DNA (cytosine-5)-methyltransferase 3A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6K1, gene: DNMT3A, swissprot: DNM3A_HUMAN) | None | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Teratogens (Code: D013723) | 2006-05-02 FDA | |
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| diphenan | None | |
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| salinazid | None | |
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| dextrofemine | None | |
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| cyprodenate | None | |
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| buclosamide | None | |
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| tulobuterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| pamidronic acid | Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Hypoxanthine-guanine phosphoribosyltransferase (Organism: Trypanosoma brucei brucei, class: Unclassified, accessions: Q07010, gene: HGPRT, swissprot: HPRT_TRYBB) Farnesyl pyrophosphate synthase (Organism: Leishmania donovani, class: Enzyme, accessions: Q0GKD7, gene: None, swissprot: Q0GKD7_LEIDO) | inhibits osteolytic bone lesions; inhibits the mevalonate pathway, which is required for the prenylation of the small GTPase; RN given refers to parent cpd | Bisphosphonate (Code: N0000175579) Diphosphonates (Code: N0000007707) Bone Density Conservation Agents (Code: D050071) | 1991-10-31 FDA | 2F89 3SDR 4KPJ 4NKF 4OGU 5ERM 5ERO |
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| chlorquinaldol | Botulinum neurotoxin type A (Organism: Clostridium botulinum, class: Enzyme, accessions: P10845, gene: botA, swissprot: BXA1_CLOBO) | Local anti-infective agent used for skin, gastrointestinal, and vaginal infections with fungi, protozoa, and certain bacteria. In animals, it causes central nervous system damage and is not administered parenterally. It is also used as antiseptic, fungistat, or deodorant. | antibacterial drug (Code: CHEBI:36047) antiseptic drug (Code: CHEBI:48218) antiprotozoal drug (Code: CHEBI:35820) Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anti-Infective Agents (Code: D000890) | |
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| pemirolast | None | Decreased Histamine Release (Code: N0000175628) Mast Cell Stabilizer (Code: N0000175630) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | 1999-09-24 FDA | |
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| guaiacol benzoate | None | |
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| oxybenzone | Hormone-sensitive lipase (Organism: Rattus norvegicus, class: Enzyme, accessions: P15304, gene: Lipe, swissprot: LIPS_RAT) | None | dermatologic drug (Code: CHEBI:50177) protective agent (Code: CHEBI:50267) Cosmetics (Code: D003358) Dermatologic Agents (Code: D003879) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) Sunscreening Agents (Code: D013473) | 1992-12-07 FDA | |
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| ozagrel | Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Thromboxane-A synthase (Organism: Rattus norvegicus, class: Enzyme, accessions: P49430, gene: Tbxas1, swissprot: THAS_RAT) | None | Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | |
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| nabumetone | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) prodrug (Code: CHEBI:50266) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1991-12-24 FDA | 3TAJ 6CI6 |
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| indalpine | Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) | selective 5-hydroxytryptamine uptake inhibitor; RN given refers to parent cpd | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | |
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| fenpentadiol | None | |
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| sapropterin | Phenylalanine-4-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: P00439, gene: PAH, swissprot: PH4H_HUMAN) Nitric oxide synthase, brain (Organism: Homo sapiens, class: Enzyme, accessions: P29475, gene: NOS1, swissprot: NOS1_HUMAN) | None | diagnostic agent (Code: CHEBI:33295) Phenylalanine Hydroxylase Activator (Code: N0000190483) Phenylalanine Hydroxylase Activators (Code: N0000190482) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) P-Glycoprotein Inhibitors (Code: N0000185503) | 2008-12-02 EMA 2007-12-13 FDA | |
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| fenamisal | None | None FDA | |
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| osalmid | None | |
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| amiloride | Sodium/hydrogen exchanger 5 (Organism: Homo sapiens, class: Unclassified, accessions: Q14940, gene: SLC9A5, swissprot: SL9A5_HUMAN) Acid-sensing ion channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q16515, gene: ASIC2, swissprot: ASIC2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Sodium/hydrogen exchanger (Organism: Amphiuma tridactylum, class: Unclassified, accessions: Q9W6Q1, gene: NHE1, swissprot: Q9W6Q1_9SALA) Membrane primary amine oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: O08590, gene: Aoc3, swissprot: AOC3_RAT) Acid-sensing ion channel 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UHC3, gene: ASIC3, swissprot: ASIC3_HUMAN) Amiloride-sensitive sodium channel, ENaC (Organism: Homo sapiens, class: Ion channel, accessions: P37088|P51168|P51170, gene: SCNN1A|SCNN1B|SCNN1G, swissprot: SCNNA_HUMAN|SCNNB_HUMAN|SCNNG_HUMAN) Amiloride-sensitive sodium channel subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P37088, gene: SCNN1A, swissprot: SCNNA_HUMAN) Acid-sensing ion channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: P78348, gene: ASIC1, swissprot: ASIC1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Sodium/hydrogen exchanger 1 (Organism: Homo sapiens, class: Transporter, accessions: P19634, gene: SLC9A1, swissprot: SL9A1_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Urokinase-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00749, gene: PLAU, swissprot: UROK_HUMAN) | A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) | diuretic (Code: CHEBI:35498) Decreased Renal K+ Excretion (Code: N0000008859) Increased Diuresis (Code: N0000175359) Potassium-sparing Diuretic (Code: N0000175418) Acid Sensing Ion Channel Blockers (Code: D062646) Diuretics (Code: D004232) Epithelial Sodium Channel Blockers (Code: D062686) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Channel Blockers (Code: D026941) | 1981-10-05 FDA | 1F5L 4NTX |
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| furonazide | None | |
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| enfenamic acid | inhibits platelet aggregation | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Hematologic Agents (Code: D006401) Peripheral Nervous System Agents (Code: D018373) Platelet Aggregation Inhibitors (Code: D010975) Sensory System Agents (Code: D018689) | |
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| lamivudine | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Protein P (Organism: Hepatitis B virus, class: Polyprotein, accessions: Q9IF40, gene: P, swissprot: Q9IF40_HBV) Deoxycytidine kinase (Organism: Homo sapiens, class: Kinase, accessions: P27707, gene: DCK, swissprot: DCK_HUMAN) | A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. | antiviral drug (Code: CHEBI:36044) prodrug (Code: CHEBI:50266) Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175656) Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175462) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1995-11-17 FDA | 2NOA |
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| furfenorex | None | |
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| pronetalol | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) | None | |
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| triclofos | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) | derivative 7 metabolic precursor of trichloroethanol; RN given refers to parent cpd; structure | None FDA | |
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| bifemelane | Lethal(3)malignant brain tumor-like protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9Y468, gene: L3MBTL1, swissprot: LMBL1_HUMAN) | None | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| indeloxazine | None | Anticonvulsants (Code: D000927) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| clonidine | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Nischarin (Organism: Rattus norvegicus, class: Unclassified, accessions: Q4G017, gene: Nisch, swissprot: NISCH_RAT) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Mus musculus, class: Unclassified, accessions: O70507, gene: Hcn4, swissprot: HCN4_MOUSE) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Organism: Mus musculus, class: Ion channel, accessions: O88703, gene: Hcn2, swissprot: HCN2_MOUSE) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Organism: Mus musculus, class: Ion channel, accessions: O88704, gene: Hcn1, swissprot: HCN1_MOUSE) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) | An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION. | sympatholytic agent (Code: CHEBI:66991) antihypertensive agent (Code: CHEBI:35674) non-narcotic analgesic (Code: CHEBI:35481) alpha-adrenergic agonist (Code: CHEBI:35569) Adrenergic alpha2-Agonists (Code: N0000009918) Central alpha-2 Adrenergic Agonist (Code: N0000175554) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Analgesics (Code: D000700) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Sympatholytics (Code: D013565) | 1974-09-03 FDA | |
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| naproxen | Prostaglandin-H2 D-isomerase (Organism: Mus musculus, class: Enzyme, accessions: O09114, gene: Ptgds, swissprot: PTGDS_MOUSE) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Hormone-sensitive lipase (Organism: Rattus norvegicus, class: Enzyme, accessions: P15304, gene: Lipe, swissprot: LIPS_RAT) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Gout Suppressants (Code: D006074) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1976-03-11 FDA | 2VDB 3NT1 3R58 4FJP 4JQ1 4OR0 4OT2 4PO0 4ZBR 5DBY |
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| propyphenazone | Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) peripheral nervous system drug (Code: CHEBI:49110) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| mefenamic acid | Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Aldo-keto reductase family 1 member C1 (Organism: Homo sapiens, class: Enzyme, accessions: Q04828, gene: AKR1C1, swissprot: AK1C1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Aldo-keto reductase family 1 member B10 (Organism: Homo sapiens, class: Enzyme, accessions: O60218, gene: AKR1B10, swissprot: AK1BA_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) | A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) analgesic (Code: CHEBI:35480) antirheumatic drug (Code: CHEBI:35842) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1967-03-28 FDA | 2XN3 3R43 4G2Z 4JQA 5IKR |
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| ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Organism: Homo sapiens, class: Enzyme, accessions: Q08499, gene: PDE4D, swissprot: PDE4D_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Organism: Homo sapiens, class: Enzyme, accessions: Q08493, gene: PDE4C, swissprot: PDE4C_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) | None | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Peripheral Nervous System Agents (Code: D018373) Phosphodiesterase Inhibitors (Code: D010726) Platelet Aggregation Inhibitors (Code: D010975) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) | 1989-05-01 PMDA | 4GRQ |
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| diazoxide | Nicotinamide phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P43490, gene: NAMPT, swissprot: NAMPT_HUMAN) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) ATP-sensitive inward rectifier potassium channel 11 (Organism: Mus musculus, class: Unclassified, accessions: Q61743, gene: Kcnj11, swissprot: KCJ11_MOUSE) | A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. | antihypertensive agent (Code: CHEBI:35674) sympathomimetic agent (Code: CHEBI:35524) cardiotonic drug (Code: CHEBI:38147) bronchodilator agent (Code: CHEBI:35523) beta-adrenergic agonist (Code: CHEBI:35522) diuretic (Code: CHEBI:35498) vasodilator agent (Code: CHEBI:35620) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1973-01-22 FDA | 4LV9 |
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| guanabenz | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. | Adrenergic alpha2-Agonists (Code: N0000009918) Central alpha-2 Adrenergic Agonist (Code: N0000175554) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1982-09-07 FDA | |
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| methaniazide | None | |
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| fenfluramine | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) | A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release. | serotonin uptake inhibitor (Code: CHEBI:50949) serotonergic agonist (Code: CHEBI:35941) appetite depressant (Code: CHEBI:50507) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | |
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| dexfenfluramine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine agonist activity. | serotonin uptake inhibitor (Code: CHEBI:50949) serotonergic agonist (Code: CHEBI:35941) appetite depressant (Code: CHEBI:50507) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 1970-01-01 YEAR INTRODUCED | |
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| aminophenazone | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS. | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) | 1964-01-01 YEAR INTRODUCED | |
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| sulfathiourea | None | antibacterial drug (Code: CHEBI:36047) | |
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| eptazocine | None | |
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| taurosteine | None | |
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| nifurprazine | None | |
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| phenobarbital | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | anticonvulsant (Code: CHEBI:35623) sedative (Code: CHEBI:35717) drug allergen (Code: CHEBI:88188) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Cytochrome P-450 CYP2B6 Inducers (Code: D065695) Cytochrome P-450 CYP3A Inducers (Code: D065701) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) | 1912-01-01 YEAR INTRODUCED | |
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| nalidixic acid | DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) | A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1964-03-06 FDA | |
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| todralazine | An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects. | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | |
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| mebutamate | None | None FDA | |
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| isonixin | None | |
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| mofebutazone | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| melatonin | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Melatonin receptor (Organism: Gallus gallus, class: GPCR, accessions: P49285|P49288|P51050, gene: None, swissprot: MTR1A_CHICK|MTR1B_CHICK|MTR1C_CHICK) Melatonin receptor type 1B (Organism: Gallus gallus, class: GPCR, accessions: P51050, gene: None, swissprot: MTR1B_CHICK) Nuclear receptor ROR-alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P35398, gene: RORA, swissprot: RORA_HUMAN) Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) | A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant. | anticonvulsant (Code: CHEBI:35623) central nervous system depressant (Code: CHEBI:35488) immunological adjuvant (Code: CHEBI:50847) Antioxidants (Code: D000975) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Protective Agents (Code: D020011) | None FDA | 2QWX 2QX4 2QX6 4QOG 4QOI 5I8F |
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| aminoglutethimide | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Aromatase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22443, gene: Cyp19a1, swissprot: CP19A_RAT) Cytochrome P450 11A1 (Organism: Bos taurus, class: Unclassified, accessions: P00189, gene: CYP11A1, swissprot: CP11A_BOVIN) Cholesterol side-chain cleavage enzyme, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P05108, gene: CYP11A1, swissprot: CP11A_HUMAN) | An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER. | Adrenal Steroid Synthesis Inhibitor (Code: N0000175928) Adrenal Steroid Synthesis Inhibitors (Code: N0000175921) antineoplastic agent (Code: CHEBI:35610) adrenergic agent (Code: CHEBI:37962) anticonvulsant (Code: CHEBI:35623) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 1980-10-29 FDA | |
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| pyrrocaine | None | |
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| lomustine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | An alkylating agent of value against both hematologic malignancies and solid tumors. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1976-08-04 FDA | |
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| tymazoline | None | |
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| symclosene | None | |
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| acitazanolast | a leukotriene D4 antagonist | |
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| sulbactam | Beta-lactamase GES-13 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: D1MIX9, gene: blaGES-13, swissprot: D1MIX9_PSEAI) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q7X575, gene: SHV-11, swissprot: Q7X575_ECOLX) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: P05364, gene: ampC, swissprot: AMPC_ENTCL) Beta-lactamase TEM (Organism: Escherichia coli, class: Enzyme, accessions: P62593, gene: bla; blaT-3; blaT-4;, swissprot: BLAT_ECOLX) Beta-lactamase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P00807, gene: blaZ, swissprot: BLAC_STAAU) Beta-lactamase (Organism: Acinetobacter pittii, class: Enzyme, accessions: Q0VTR6, gene: adc-14, swissprot: Q0VTR6_ACIPI) Beta-lactamase (Organism: Acinetobacter pittii, class: Enzyme, accessions: Q0VTR8, gene: adc-16, swissprot: Q0VTR8_ACIPI) Carbapenem-hydrolizing beta-lactamase SFC-1 (Organism: Serratia fonticola, class: Enzyme, accessions: Q6JP75, gene: None, swissprot: Q6JP75_SERFO) ADC-18 protein (Organism: Acinetobacter pittii, class: Unclassified, accessions: Q0VTS0, gene: adc-18, swissprot: Q0VTS0_ACIPI) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Beta-lactamase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: P24735, gene: ampC, swissprot: AMPC_PSEAE) Beta-lactamase 1 (Organism: Bacillus cereus, class: Unclassified, accessions: P00809, gene: blaY, swissprot: BLAC_BACCE) Beta-lactamase (Organism: Aeromonas allosaccharophila, class: Enzyme, accessions: D5HSX5, gene: blaPER-6, swissprot: D5HSX5_9GAMM) Beta-lactamase (Organism: Bacillus clausii, class: Enzyme, accessions: A8RR46, gene: bcl1, swissprot: A8RR46_BACCS) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: A1E3K9, gene: blaSCO-1, swissprot: A1E3K9_ECOLX) Beta-lactamase OXA-1 (Organism: Escherichia coli, class: Enzyme, accessions: P13661, gene: bla, swissprot: BLO1_ECOLX) Class D beta-lactamase (Organism: Brachyspira pilosicoli, class: Unclassified, accessions: Q50H31, gene: oxa-63, swissprot: Q50H31_BRAPL) Beta-lactamase TEM (Organism: Salmonella typhi, class: Enzyme, accessions: P62594, gene: bla, swissprot: BLAT_SALTI) Serine beta-lactamase-like protein LACTB, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P83111, gene: LACTB, swissprot: LACTB_HUMAN) | A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone. | beta Lactamase Inhibitor (Code: N0000175930) beta Lactamase Inhibitors (Code: N0000000202) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) beta-Lactamase Inhibitors (Code: D065093) Enzyme Inhibitors (Code: D004791) | 1986-12-31 FDA | 4FH2 |
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| hexobarbital | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A barbiturate that is effective as a hypnotic and sedative. | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | 1932-01-01 YEAR INTRODUCED | |
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| hopantenic acid | None | |
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| riluzole | Intermediate conductance calcium-activated potassium channel protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: O15554, gene: KCNN4, swissprot: KCNN4_HUMAN) Small conductance calcium-activated potassium channel protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UGI6, gene: KCNN3, swissprot: KCNN3_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Pteridine reductase 1 (Organism: Leishmania major, class: Enzyme, accessions: Q01782, gene: PTR1, swissprot: PTR1_LEIMA) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Small conductance calcium-activated potassium channel protein 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P70604, gene: Kcnn2, swissprot: KCNN2_RAT) Small conductance calcium-activated potassium channel protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q92952, gene: KCNN1, swissprot: KCNN1_HUMAN) | A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. | Benzothiazole (Code: N0000175740) Benzothiazoles (Code: N0000167094) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Neuroprotective Agents (Code: D018696) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1995-12-12 FDA | 5V02 |
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| cyclopentobarbital | None | |
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| epirizole | 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| metisazone | An antiviral agent effective against pox viruses. | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | |
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| thiopental | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Potassium voltage-gated channel subfamily C member 4 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63734, gene: Kcnc4, swissprot: KCNC4_RAT) | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. | Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) drug allergen (Code: CHEBI:88188) anticonvulsant (Code: CHEBI:35623) sedative (Code: CHEBI:35717) intravenous anaesthetic (Code: CHEBI:38877) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | None FDA | 3RD0 5L4E |
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| cyclobarbital | None | |
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| monoctanoin | dissolution agent for retained cholesterol bile duct stones; RN in Chemline for octanoic acid, ester with 1,2,3-propanetriol, MF unknown: 11140-04-8; RN for octanoic acid, 2,3-dihydroxypropyl ester (1-monooctanoin): 502-54-5; RN in 9th CI Form Index for (+-)-1-monooctanoin: 19670-49-6 | 1985-10-29 FDA | 4Y13 |
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| stiripentol | Sodium- and chloride-dependent GABA transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P30531, gene: SLC6A1, swissprot: SC6A1_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) | In animal models, stiripentol antagonizes seizures induced by electric shock, pentetrazole and bicuculline. In rodent models, stiripentol appears to increase brain levels of gamma-aminobutyric acid (GABA) - the major inhibitory neurotransmitter in mammalian brain. This could occur by inhibition of synaptosomal uptake of GABA and/or inhibition of GABA transaminase. Stiripentol has also been shown to enhance GABAA receptor-mediated transmission in the immature rat hippocampus and increase the mean open-duration (but not the frequency) of GABAA receptor chloride channels by a barbiturate-like mechanism. Stiripentol potentiates the efficacy of other anticonvulsants, such as carbamazepine, sodium valproate, phenytoin, phenobarbital and many benzodiazepines, as the result of pharmacokinetic interactions. The second effect of stiripentol is mainly based on metabolic inhibition of several isoenzymes, in particular CYP450 3A4 and 2C19, involved in the hepatic metabolism of other anti-epileptic medicines. | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 2007-01-04 EMA | |
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| octacaine | None | |
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| meprylcaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | |
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| amylocaine | None | |
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| carbamazepine | Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) | An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) drug allergen (Code: CHEBI:88188) non-narcotic analgesic (Code: CHEBI:35481) analgesic (Code: CHEBI:35480) antimanic drug (Code: CHEBI:35477) anticonvulsant (Code: CHEBI:35623) glutamate transporter activator (Code: CHEBI:64370) Anticonvulsants (Code: D000927) Antimanic Agents (Code: D018692) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Cytochrome P-450 CYP3A Inducers (Code: D065701) Metabolic Side Effects of Drugs and Substances (Code: D065606) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Mood Stabilizer (Code: N0000175751) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 1A2 Inducers (Code: N0000191266) Cytochrome P450 2B6 Inducers (Code: N0000187064) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 2C19 Inducers (Code: N0000185607) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) | 1968-03-11 FDA | |
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| azapetine | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) | None | |
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| procainamide | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) DNA (cytosine-5)-methyltransferase 3B (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBC3, gene: DNMT3B, swissprot: DNM3B_HUMAN) DNA (cytosine-5)-methyltransferase 3A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6K1, gene: DNMT3A, swissprot: DNM3A_HUMAN) DNA (cytosine-5)-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P26358, gene: DNMT1, swissprot: DNMT1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) | A class Ia antiarrhythmic drug that is structurally-related to PROCAINE. | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) platelet aggregation inhibitor (Code: CHEBI:50427) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1950-06-02 FDA | |
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| carbocloral | None | |
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| picilorex | None | |
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| isosorbide dinitrate | Soluble guanylate cyclase (Organism: Homo sapiens, class: Enzyme, accessions: O75343|P33402|Q02108|Q02153, gene: GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3, swissprot: GCYA2_HUMAN|GCYA3_HUMAN|GCYB1_HUMAN|GCYB2_HUMAN) Atrial natriuretic peptide receptor 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16066, gene: NPR1, swissprot: ANPRA_HUMAN) | A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. | Nitrate Vasodilator (Code: N0000175415) Nitrates (Code: N0000007647) Vasodilation (Code: N0000009909) vasodilator agent (Code: CHEBI:35620) Cardiovascular Agents (Code: D002317) Nitric Oxide Donors (Code: D020030) Vasodilator Agents (Code: D014665) | 1968-01-16 FDA | |
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| didanosine | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72549, gene: pol, swissprot: Q72549_9HIV1) | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175462) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1991-10-09 FDA | 1V3Q |
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| zileuton | Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) Arachidonate 5-lipoxygenase-activating protein (Organism: Homo sapiens, class: Cytosolic other, accessions: P20292, gene: ALOX5AP, swissprot: AL5AP_HUMAN) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Leukotriene B4 receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q15722, gene: LTB4R, swissprot: LT4R1_HUMAN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Cysteinyl leukotriene receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9NS75, gene: CYSLTR2, swissprot: CLTR2_HUMAN) Leukotriene A-4 hydrolase (Organism: Homo sapiens, class: Enzyme, accessions: P09960, gene: LTA4H, swissprot: LKHA4_HUMAN) Arachidonate 5-lipoxygenase (Organism: Mus musculus, class: Enzyme, accessions: P48999, gene: Alox5, swissprot: LOX5_MOUSE) | an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid | 5-Lipoxygenase Inhibitor (Code: N0000175956) 5-Lipoxygenase Inhibitors (Code: N0000175955) Decreased Leukotriene Production (Code: N0000008683) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) leukotriene antagonist (Code: CHEBI:49159) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) anti-asthmatic drug (Code: CHEBI:49167) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Leukotriene Antagonists (Code: D020024) Lipoxygenase Inhibitors (Code: D016859) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1996-12-09 FDA | |
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| thioacetazone | A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217) | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) | |
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| butethamine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | |
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| procaine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Ryanodine receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P21817, gene: RYR1, swissprot: RYR1_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) | A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) central nervous system depressant (Code: CHEBI:35488) peripheral nervous system drug (Code: CHEBI:49110) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1954-07-01 FDA | |
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| levodropropizine | None | antitussive (Code: CHEBI:51177) | |
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| dropropizine | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| agomelatine | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Melatonin receptor (Organism: Gallus gallus, class: GPCR, accessions: P49285|P49288|P51050, gene: None, swissprot: MTR1A_CHICK|MTR1B_CHICK|MTR1C_CHICK) Melatonin receptor (Organism: Homo sapiens, class: GPCR, accessions: P48039|P49286, gene: MTNR1A|MTNR1B, swissprot: MTR1A_HUMAN|MTR1B_HUMAN) Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) | an antidepressant, it works by stimulating the MT1 and MT2 receptors, which are normally activated by melatonin, and also by blocking the 5-HT2C receptors, which are normally activated by the neurotransmitter 5-hydroxytryptamine | 2009-02-19 EMA | |
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| tilbroquinol | None | |
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| nitrofurantoin | Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) | A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression. | Nitrofuran Antibacterial (Code: N0000175494) Nitrofurans (Code: N0000007658) antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | 1953-02-06 FDA | |
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| rufinamide | Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) | The precise mechanism(s) by which rufinamide exerts its antiepileptic effect is unknown. The results of in vitro studies suggest that the principal mechanism of action of rufinamide is modulation of the activity of sodium channels and, in particular, prolongation of the inactive state of the channel. | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 2007-01-16 EMA 2008-11-14 FDA | |
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| dipyrocetyl | None | |
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| acefylline | Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) | None | |
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| pronilide | None | |
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| felbamate | Glutamate receptor ionotropic, NMDA 2B (Organism: Homo sapiens, class: Ion channel, accessions: Q13224, gene: GRIN2B, swissprot: NMDE2_HUMAN) Glutamate receptor ionotropic, NMDA 2A (Organism: Homo sapiens, class: Ion channel, accessions: Q12879, gene: GRIN2A, swissprot: NMDE1_HUMAN) | an orphan drug; used as therapy for the treatment of partial and generalized seizures | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) neuroprotective agent (Code: CHEBI:63726) anticonvulsant (Code: CHEBI:35623) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1993-07-29 FDA | |
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| protheobromine | None | |
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| proxyphylline | None | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| frovatriptan | 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | None | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 2001-11-08 FDA | |
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| nealbarbital | None | |
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| secobarbital | Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity. | Adjuvants, Anesthesia (Code: D000759) anaesthesia adjuvant (Code: CHEBI:60807) GABA modulator (Code: CHEBI:50268) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | 1950-07-19 FDA | |
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| nomifensine | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Hemoglobin HbA (Organism: Homo sapiens, class: Enzyme, accessions: P68871|P69905, gene: HBA1|HBB, swissprot: HBA_HUMAN|HBB_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) | An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266) | dopamine uptake inhibitor (Code: CHEBI:51039) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | None FDA | |
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| metapramine | None | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| flosequinan | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| phencyclidine | Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) Lysosomal Pro-X carboxypeptidase (Organism: Homo sapiens, class: Enzyme, accessions: P42785, gene: PRCP, swissprot: PCP_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Muscarinic acetylcholine receptor (Organism: Mus musculus, class: GPCR, accessions: P12657|P32211|Q920H4|Q9ERZ3|Q9ERZ4, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_MOUSE|ACM2_MOUSE|ACM3_MOUSE|ACM4_MOUSE|ACM5_MOUSE) Glutamate receptor ionotropic, NMDA 2C (Organism: Rattus norvegicus, class: Ion channel, accessions: Q00961, gene: Grin2c, swissprot: NMDE3_RAT) Cholinesterase (Organism: Mus musculus, class: Enzyme, accessions: Q03311, gene: Bche, swissprot: CHLE_MOUSE) Glutamate NMDA receptor; GRIN1/GRIN2B (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q13224, gene: GRIN1|GRIN2B, swissprot: NMDE2_HUMAN|NMDZ1_HUMAN) Glutamate NMDA receptor; GRIN1/GRIN2A (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q12879, gene: GRIN1|GRIN2A, swissprot: NMDE1_HUMAN|NMDZ1_HUMAN) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) | A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust. | psychotropic drug (Code: CHEBI:35471) anaesthetic (Code: CHEBI:38867) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Hallucinogens (Code: D006213) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) | 2PCP |
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| emorfazone | None | None PMDA | |
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| levomoprolol | None | |
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| moprolol | (-)-moprolol is beta-blocker & anti-hypertensive agent; (+)-moprolol is inactive; SD 1601 refers to HCl; RN given refers to parent cpd without isomeric designation; structure in Negwer, 5th ed, #6316 | |
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| levosalbutamol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | The R-isomer of albuterol. | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) | 1999-03-25 FDA | 2Y04 |
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| isoetarine | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 1979-10-23 FDA | |
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| iproclozide | None | |
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| benzphetamine | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Appetite Suppression (Code: N0000175372) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic Amine Anorectic (Code: N0000175423) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) sympathomimetic agent (Code: CHEBI:35524) dopamine uptake inhibitor (Code: CHEBI:51039) appetite depressant (Code: CHEBI:50507) adrenergic uptake inhibitor (Code: CHEBI:35640) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1960-10-26 FDA | |
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| bupropion | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297, gene: CHRNA3|CHRNB2, swissprot: ACHA3_HUMAN|ACHB2_HUMAN) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) | A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. | Aminoketone (Code: N0000180855) Increased Dopamine Activity (Code: N0000009282) Increased Norepinephrine Activity (Code: N0000009456) Norepinephrine Uptake Inhibitors (Code: N0000000102) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Cytochrome P-450 CYP2D6 Inhibitors (Code: D065690) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1985-12-30 FDA | |
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| dantron | mild purgative anthraquinone derivative chemically related to emodin, the active principle of cascara and other naturally occurring products such as senna, aloes and rhubarb, it acts on the nerve endings of the myenteric plexus and stimulates the muscles of the large intestine | Cathartics (Code: D002400) Gastrointestinal Agents (Code: D005765) Mutagens (Code: D009153) Noxae (Code: D009676) | 1994-10-19 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | 3NSQ |
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| fluindione | Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) | None | Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | |
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| imiquimod | Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Toll-like receptor 7 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q9NYK1, gene: TLR7, swissprot: TLR7_HUMAN) | effective against herpes simplex virus infections in animals; structure given in first source | Increased Cytokine Activity (Code: N0000009267) Increased Cytokine Production (Code: N0000009269) Adjuvants, Immunologic (Code: D000276) antineoplastic agent (Code: CHEBI:35610) interferon inducer (Code: CHEBI:36710) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Interferon Inducers (Code: D007369) | 1998-09-18 EMA 1997-02-27 FDA | 5LBT |
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| budralazine | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| buthalital | None | |
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| cropropamide | component of prethcamide; same pharmacological activity as prethacamide; RN given refers to cpd without isomeric designation; structure | |
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| pheniramine | Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. | Anti-Allergic Agents (Code: D018926) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1994-06-08 FDA | |
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| anethole trithione | Choleretic used to allay dry mouth and constipation due to tranquilizers. | |
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| thiram | Monoglyceride lipase (Organism: Homo sapiens, class: Enzyme, accessions: Q99685, gene: MGLL, swissprot: MGLL_HUMAN) Fatty-acid amide hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O00519, gene: FAAH, swissprot: FAAH1_HUMAN) Gamma-butyrobetaine dioxygenase (Organism: Homo sapiens, class: Enzyme, accessions: O75936, gene: BBOX1, swissprot: BODG_HUMAN) Bifunctional protein GlmU (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WMN3, gene: glmU, swissprot: GLMU_MYCTU) | A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations. | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) antifungal agrochemical (Code: CHEBI:86328) antibacterial drug (Code: CHEBI:36047) antiseptic drug (Code: CHEBI:48218) Fungicides, Industrial (Code: D005659) Mutagens (Code: D009153) Noxae (Code: D009676) Pesticides (Code: D010575) | |
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| moxonidine | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Nischarin (Organism: Rattus norvegicus, class: Unclassified, accessions: Q4G017, gene: Nisch, swissprot: NISCH_RAT) | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | 1991-01-01 YEAR INTRODUCED | |
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| nidroxyzone | None | |
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| benzoyl peroxide | A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry. | Dermatologic Agents (Code: D003879) | 1984-10-26 FDA | |
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| mexenone | None | |
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| fenoprofen | Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Sodium-coupled monocarboxylate transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q8N695, gene: SLC5A8, swissprot: SC5A8_HUMAN) | A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1976-03-16 FDA | 2X7H 4NED |
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| myrtecaine | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | None | |
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| methylsulfonal | None | |
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| dixanthogen | None | |
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| clofibrate | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) | A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) | anticholesteremic drug (Code: CHEBI:35821) antilipemic drug (Code: CHEBI:35679) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 1967-02-08 FDA | |
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| cytarabine | Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), class: Enzyme, accessions: Q5NGQ3, gene: fabI, swissprot: Q5NGQ3_FRATT) DNA polymerase (alpha/delta/epsilon) (Organism: Homo sapiens, class: Enzyme, accessions: P09884|P28340|Q07864, gene: POLA1|POLD1|POLE, swissprot: DPOD1_HUMAN|DPOE1_HUMAN|DPOLA_HUMAN) Prostatic acid phosphatase (Organism: Homo sapiens, class: Enzyme, accessions: P15309, gene: ACPP, swissprot: PPAP_HUMAN) DNA polymerase beta (Organism: Homo sapiens, class: Enzyme, accessions: P06746, gene: POLB, swissprot: DPOLB_HUMAN) | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472) | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) | 1969-06-17 FDA | 1P5Z 5Y9A |
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| taribavirin | None | |
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| molsidomine | A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS. | Cardiovascular Agents (Code: D002317) Nitric Oxide Donors (Code: D020030) Vasodilator Agents (Code: D014665) | |
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| tolperisone | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) SMR1-alpha3 (Organism: Rattus norvegicus, class: Unclassified, accessions: P70634, gene: VCS-alpha3, swissprot: P70634_RAT) BetaB2-crystallin (Organism: Rattus norvegicus, class: Unclassified, accessions: P70635, gene: Crybb2, swissprot: P70635_RAT) | A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211) | Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | |
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| pidotimod | None | Adjuvants, Immunologic (Code: D000276) Immunologic Factors (Code: D007155) | |
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| etomidate | Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P14867, gene: GABRA1, swissprot: GBRA1_HUMAN) | Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. | General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) intravenous anaesthetic (Code: CHEBI:38877) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1982-09-07 FDA | |
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| biotin | Insulin-degrading enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P14735, gene: IDE, swissprot: IDE_HUMAN) | A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. | B vitamin (Code: CHEBI:75769) nutraceutical (Code: CHEBI:50733) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | 1953-02-20 FDA | |
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| amidefrine | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Neurotransmitter Agents (Code: D018377) | |
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| xylometazoline | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor alpha (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P19328|P22086|P22909|P23944|P43140, gene: Adra1a|Adra1b|Adra1d|Adra2a|Adra2b|Adra2c, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT|ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) | nasal decongestant | Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Respiratory System Agents (Code: D019141) Vasoconstrictor Agents (Code: D014662) | None FDA | |
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| isoaminile | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| clodronic acid | Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) ADP/ATP translocase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P12236, gene: SLC25A6, swissprot: ADT3_HUMAN) ADP/ATP translocase 1 (Organism: Homo sapiens, class: Transporter, accessions: P12235, gene: SLC25A4, swissprot: ADT1_HUMAN) ADP/ATP translocase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P05141, gene: SLC25A5, swissprot: ADT2_HUMAN) | A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. | bone density conservation agent (Code: CHEBI:50646) antineoplastic agent (Code: CHEBI:35610) Bone Density Conservation Agents (Code: D050071) | 1986-01-01 YEAR INTRODUCED | |
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| apraclonidine | Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | relieves postoperative intraocular pressure following trabeculoplasty; RN given refers to parent cpd | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) ophthalmology drug (Code: CHEBI:66981) beta-adrenergic agonist (Code: CHEBI:35522) diagnostic agent (Code: CHEBI:33295) alpha-adrenergic agonist (Code: CHEBI:35569) antiglaucoma drug (Code: CHEBI:39456) Neurotransmitter Agents (Code: D018377) | 1987-12-31 FDA | |
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| menadoxime | None | |
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| ramifenazone | Ramifenazone is an analgesic, antipyretic, and anti-inflammatory agent. | |
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| dezocine | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | potent analgesic; RN given refers to ((5R-(5alpha,11alpha,13S*)))-isomer (dezocin); structure | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) opioid analgesic (Code: CHEBI:35482) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| oxolamine | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| pinacidil | ATP-binding cassette sub-family C member 9 (Organism: Homo sapiens, class: Ion channel, accessions: O60706, gene: ABCC9, swissprot: ABCC9_HUMAN) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) | A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed) | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) | None FDA | |
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| guanfacine | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS. | Adrenergic alpha2-Agonists (Code: N0000009918) Central alpha-2 Adrenergic Agonist (Code: N0000175554) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1986-10-27 FDA | |
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| floxuridine | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Thymidylate synthase (Organism: Mus musculus, class: Enzyme, accessions: P07607, gene: Tyms, swissprot: TYSY_MOUSE) | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. | Antimetabolite (Code: N0000180853) Deoxyuridine (Code: N0000007770) radiosensitizing agent (Code: CHEBI:132992) antineoplastic agent (Code: CHEBI:35610) antiviral drug (Code: CHEBI:36044) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | 1970-12-18 FDA | |
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| doxifluridine | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) | None | antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Appetite Stimulants (Code: D019167) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) | 1987-01-01 YEAR INTRODUCED | |
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| nifurpirinol | None | |
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| pethidine | Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Opioid receptor (Organism: Mus musculus, class: GPCR, accessions: O55242|P32300|P33534|P42866, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_MOUSE|OPRK_MOUSE|OPRM_MOUSE|SGMR1_MOUSE) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Adjuvants, Anesthesia (Code: D000759) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1942-11-10 FDA | |
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| azanidazole | None | |
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| methylphenobarbital | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A barbiturate that is metabolized to PHENOBARBITAL. It has been used for similar purposes, especially in EPILEPSY, but there is no evidence mephobarbital offers any advantage over PHENOBARBITAL. | anticonvulsant (Code: CHEBI:35623) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | 1935-01-01 YEAR INTRODUCED | |
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| busulfan | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) | An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) insect sterilant (Code: CHEBI:67105) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Myeloablative Agonists (Code: D019653) Noxae (Code: D009676) | 1954-06-26 FDA | |
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| parsalmide | anti-inflammatory analgesic with possible antianxiety action; minor descriptor (79-86); on-line & INDEX MEDICUS search BENZAMIDES (79-86) | |
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| nefiracetam | antagonizes amnestic effects of picrotoxin or bicuculline; structure given in first source | Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Nootropic Agents (Code: D018697) Protective Agents (Code: D020011) Psychotropic Drugs (Code: D011619) | |
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| milnacipran | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Glutamate receptor ionotropic, NMDA 2A (Organism: Homo sapiens, class: Ion channel, accessions: Q12879, gene: GRIN2A, swissprot: NMDE1_HUMAN) | levomilnacipran is the (1S,2R)-isomer; structure given in first source | Norepinephrine Uptake Inhibitors (Code: N0000000102) Serotonin and Norepinephrine Reuptake Inhibitor (Code: N0000175749) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 2009-01-14 FDA | |
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| mepivacaine | Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel protein type 8 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UQD0, gene: SCN8A, swissprot: SCN8A_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168) | Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) drug allergen (Code: CHEBI:88188) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1960-01-06 FDA | |
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| guanoxabenz | None | |
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| pyridoxal phosphate | P2X purinoceptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P51575, gene: P2RX1, swissprot: P2RX1_HUMAN) | This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | None FDA | |
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| emtricitabine | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) | A deoxycytidine analog and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B viruses. It is used to treat HIV INFECTIONS. | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175462) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 2003-10-24 EMA 2003-07-02 FDA | 2NO6 |
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| tinidazole | A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections. | Nitroimidazole Antimicrobial (Code: N0000175435) Nitroimidazoles (Code: N0000007663) Alkylating Agents (Code: D000477) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antitrichomonal Agents (Code: D000994) Noxae (Code: D009676) | 2004-05-17 FDA | |
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| ciclonicate | antilipolytic & myolytic; RN given refers to trans-isomer | |
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| ketobemidone | Opioid receptor (Organism: Mus musculus, class: GPCR, accessions: O55242|P32300|P33534|P42866, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_MOUSE|OPRK_MOUSE|OPRM_MOUSE|SGMR1_MOUSE) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Narcotics (Code: D009294) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1947-01-01 YEAR INTRODUCED | |
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| butidrine | None | |
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| triflusal | inhibits platelet aggregation similarly to aspirin; structure | Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | |
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| amoscanate | None | Anthelmintics (Code: D000871) schistosomicide drug (Code: CHEBI:38941) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Filaricides (Code: D005369) Schistosomicides (Code: D012556) | |
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| enoximone | Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) | A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE. | Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase 3 Inhibitors (Code: D058987) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | 1988-01-01 YEAR INTRODUCED | |
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| dapsone | Dihydropteroate synthase 1 (Organism: Mycobacterium leprae (strain TN), class: Enzyme, accessions: P0C0X1, gene: folP1, swissprot: DHPS1_MYCLE) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Dihydropteroate synthetase, putative (Organism: Plasmodium berghei (strain Anka), class: Unclassified, accessions: Q4Z710, gene: None, swissprot: Q4Z710_PLABA) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) | A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) | Sulfone (Code: N0000175881) Sulfones (Code: N0000008053) antimalarial (Code: CHEBI:38068) leprostatic drug (Code: CHEBI:35816) antiinfective agent (Code: CHEBI:35441) anti-inflammatory drug (Code: CHEBI:35472) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) Leprostatic Agents (Code: D007917) | 1979-07-03 FDA | |
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| piridocaine | None | |
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| pindolol | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638) | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) serotonergic antagonist (Code: CHEBI:48279) beta-adrenergic antagonist (Code: CHEBI:35530) antiglaucoma drug (Code: CHEBI:39456) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Vasodilator Agents (Code: D014665) | 1982-09-03 FDA | |
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| bunitrolol | None | |
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| pirprofen | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1982-01-01 YEAR INTRODUCED | |
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| trimecaine | Acetanilide derivative used as a local anesthetic. | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| pyrimethamine | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium falciparum, class: Enzyme, accessions: P13922, gene: None, swissprot: DRTS_PLAFK) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8K0H1, gene: Slc47a1, swissprot: S47A1_MOUSE) Dihydrofolate reductase (Organism: Candida albicans, class: Enzyme, accessions: P22906, gene: DFR1, swissprot: DYR_CANAX) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Solute carrier family 22 member 1 (Organism: Mus musculus, class: Unclassified, accessions: O08966, gene: Slc22a1, swissprot: S22A1_MOUSE) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Trypanosoma brucei brucei, class: Enzyme, accessions: Q27783, gene: None, swissprot: DRTS_TRYBB) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: Q27793, gene: None, swissprot: DRTS_TRYCR) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Leishmania major, class: Enzyme, accessions: P07382, gene: None, swissprot: DRTS_LEIMA) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Beta-hexosaminidase subunit alpha (Organism: Homo sapiens, class: Unclassified, accessions: P06865, gene: HEXA, swissprot: HEXA_HUMAN) Beta-hexosaminidase subunit beta (Organism: Homo sapiens, class: Unclassified, accessions: P07686, gene: HEXB, swissprot: HEXB_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Mus musculus, class: Unclassified, accessions: Q3V050, gene: Slc47a2, swissprot: S47A2_MOUSE) | One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Dihydrofolate Reductase Inhibitor Antimalarial (Code: N0000175934) Dihydrofolate Reductase Inhibitors (Code: N0000000191) antimalarial (Code: CHEBI:38068) antiprotozoal drug (Code: CHEBI:35820) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) | 1953-01-23 FDA | 1J3J 2BL9 2BLA 3LMY 3QFX 3QG2 3QGT 3UM5 4KM0 |
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| alprenolol | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Squalene synthase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q02769, gene: Fdft1, swissprot: FDFT_RAT) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) antihypertensive agent (Code: CHEBI:35674) beta-adrenergic antagonist (Code: CHEBI:35530) sympatholytic agent (Code: CHEBI:66991) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1966-01-01 YEAR INTRODUCED | 3NYA |
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| alendronic acid | Protein farnesyltransferase subunit beta (Organism: Homo sapiens, class: Enzyme, accessions: P49356, gene: FNTB, swissprot: FNTB_HUMAN) Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Farnesyl pyrophosphate synthase (Organism: Leishmania donovani, class: Enzyme, accessions: Q0GKD7, gene: None, swissprot: Q0GKD7_LEIDO) | A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis. | Bisphosphonate (Code: N0000175579) Diphosphonates (Code: N0000007707) bone density conservation agent (Code: CHEBI:50646) Bone Density Conservation Agents (Code: D050071) | 1995-09-29 FDA | 1YHM 2F92 3SDT 4KQU 5DZ2 |
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| cinchophen | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y233, gene: PDE10A, swissprot: PDE10_HUMAN) | None | |
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| flunoxaprofen | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) antirheumatic drug (Code: CHEBI:35842) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| sulfapyridine | Dihydropteroate synthase type-1 (Organism: Mycobacterium fortuitum, class: Enzyme, accessions: Q49184, gene: sulI, swissprot: DHP1_MYCFO) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | Antibacterial, potentially toxic, used to treat certain skin diseases. | antiinfective agent (Code: CHEBI:35441) dermatologic drug (Code: CHEBI:50177) Anti-Infective Agents (Code: D000890) Dermatologic Agents (Code: D003879) | 1939-03-09 FDA | 4HWK |
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| erdosteine | None | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | |
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| epinastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast cell, indicated for the prevention of itching associated with allergic conjunctivitis | Adrenergic Agonists (Code: N0000000122) Adrenergic Receptor Agonist (Code: N0000175883) Decreased Histamine Release (Code: N0000175628) Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Inhibitor (Code: N0000175519) anti-allergic agent (Code: CHEBI:50857) histamine antagonist (Code: CHEBI:37956) ophthalmology drug (Code: CHEBI:66981) H1-receptor antagonist (Code: CHEBI:37955) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 2003-10-16 FDA | |
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| mabuprofen | None | |
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| benzoctamine | minor descriptor (72); major descriptor (73-86); on line search ANTHRACENES (72-86); INDEX MEDICUS search ANTHRACENES (72); BENZOCTAMINE (73-86) | |
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| diflunisal | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1982-04-19 FDA | 2BXE 3D2T 4I89 5G48 |
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| nefopam | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26) | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) adrenergic uptake inhibitor (Code: CHEBI:35640) dopamine uptake inhibitor (Code: CHEBI:51039) non-narcotic analgesic (Code: CHEBI:35481) serotonin uptake inhibitor (Code: CHEBI:50949) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1978-01-01 YEAR INTRODUCED | |
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| metesculetol | None | |
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| olprinone | Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) | None | Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase 3 Inhibitors (Code: D058987) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) | 1996-04-01 PMDA | |
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| sulfadiazine | Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Plasmodium falciparum (isolate 3D7), class: Enzyme, accessions: Q08210, gene: None, swissprot: PYRD_PLAF7) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) High affinity choline transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q9GZV3, gene: SLC5A7, swissprot: SC5A7_HUMAN) | One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. | Sulfonamide Antibacterial (Code: N0000175503) Sulfonamides (Code: N0000008048) coccidiostat (Code: CHEBI:35818) antiinfective agent (Code: CHEBI:35441) antiprotozoal drug (Code: CHEBI:35820) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Coccidiostats (Code: D003049) | 1941-08-11 FDA | |
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| heptabarb | None | |
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| methaqualone | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-4/beta-2/delta (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P47870|P48169, gene: GABRA4|GABRB2|GABRD, swissprot: GBRA4_HUMAN|GBRB2_HUMAN|GBRD_HUMAN) GABA A receptor alpha-4/beta-3/delta (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P28472|P48169, gene: GABRA4|GABRB3|GABRD, swissprot: GBRA4_HUMAN|GBRB3_HUMAN|GBRD_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-6/beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47870|Q16445, gene: GABRA6|GABRB2, swissprot: GBRA6_HUMAN|GBRB2_HUMAN) GABA-A receptor alpha-6/beta-2/delta (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P47870|Q16445, gene: GABRA6|GABRB2|GABRD, swissprot: GBRA6_HUMAN|GBRB2_HUMAN|GBRD_HUMAN) GABA-A receptor alpha-6/beta-3/delta (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P28472|Q16445, gene: GABRA6|GABRB3|GABRD, swissprot: GBRA6_HUMAN|GBRB3_HUMAN|GBRD_HUMAN) | A quinazoline derivative with hypnotic and sedative properties. It has been withdrawn from the market in many countries because of problems with abuse. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | GABA agonist (Code: CHEBI:51373) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1965-01-01 YEAR INTRODUCED | |
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| xibenolol | None | |
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| butazolamide | None | |
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| gemfibrozil | Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Cytochrome P450 2C8 (Organism: Homo sapiens, class: Enzyme, accessions: P10632, gene: CYP2C8, swissprot: CP2C8_HUMAN) Lipoprotein lipase (Organism: Homo sapiens, class: Enzyme, accessions: P06858, gene: LPL, swissprot: LIPL_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. | Peroxisome Proliferator Receptor alpha Agonist (Code: N0000175596) Peroxisome Proliferator-activated Receptor alpha Agonists (Code: N0000175375) PPAR alpha (Code: N0000170118) antilipemic drug (Code: CHEBI:35679) Antimetabolites (Code: D000963) Cytochrome P-450 CYP2C8 Inhibitors (Code: D065687) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Metabolic Side Effects of Drugs and Substances (Code: D065606) | 1981-12-21 FDA | 5BOJ |
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| naepaine | None | |
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| rivastigmine | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Cholinesterase (Organism: Mus musculus, class: Enzyme, accessions: Q03311, gene: Bche, swissprot: CHLE_MOUSE) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) | A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE. | Cholinesterase Inhibitor (Code: N0000175723) neuroprotective agent (Code: CHEBI:63726) cholinergic drug (Code: CHEBI:38323) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neuroprotective Agents (Code: D018696) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1998-05-12 EMA 2000-04-21 FDA | |
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| amfetaminil | a supposedly insoluble amphetamine complex that may release amphetamine; proposed as central nervous system stimulant; minor desriptor (78-86); on line & INDEX MEDICUS search AMPHETAMINES (75-86); RN given refers to parent compound | |
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| alibendol | None | |
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| dimethazan | None | |
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| rimazolium | None | |
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| uracil mustard | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1962-09-13 FDA | |
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| anisindione | Vitamin K-dependent gamma-carboxylase (Organism: Homo sapiens, class: Enzyme, accessions: P38435, gene: GGCX, swissprot: VKGC_HUMAN) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) | a synthetic anticoagulant it exercises its therapeutic action by reducing the prothrombin activity of the blood by inhibiting the vitamin K-mediated gamma-carboxylation of precursor proteins | anticoagulant (Code: CHEBI:50249) | 1957-04-05 FDA | |
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| phenytoin | Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) Sodium channel protein type 8 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UQD0, gene: SCN8A, swissprot: SCN8A_HUMAN) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) | An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Cytochrome P450 1A2 Inducers (Code: N0000191266) Cytochrome P450 2B6 Inducers (Code: N0000187064) Cytochrome P450 2C8 Inducers (Code: N0000187063) Cytochrome P450 2C19 Inducers (Code: N0000185607) Cytochrome P450 2D6 Inducers (Code: N0000191267) Cytochrome P450 3A Inducers (Code: N0000190118) Cytochrome P450 2C9 Inducers (Code: N0000185507) drug allergen (Code: CHEBI:88188) anticonvulsant (Code: CHEBI:35623) Anticonvulsants (Code: D000927) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cytochrome P-450 CYP1A2 Inducers (Code: D065694) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1953-01-06 FDA | |
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| oxcarbazepine | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | an antiepileptic drug, precise mechanism by which oxcarbazepine exerts its antiseizure effect is unknown, however, in vitro electrophysiological studies indicate that it produces blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminution of propagation of synaptic impulses | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) anticonvulsant (Code: CHEBI:35623) Anticonvulsants (Code: D000927) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cytochrome P-450 CYP3A Inducers (Code: D065701) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 2000-01-14 FDA | |
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| cimetidine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Histamine H2 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P47747, gene: HRH2, swissprot: HRH2_CAVPO) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Histamine H2 receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P25102, gene: Hrh2, swissprot: HRH2_RAT) | A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output. | Histamine H2 Receptor Antagonists (Code: N0000000151) Histamine-2 Receptor Antagonist (Code: N0000175784) H2-receptor antagonist (Code: CHEBI:37961) analgesic (Code: CHEBI:35480) adjuvant (Code: CHEBI:60809) anti-ulcer drug (Code: CHEBI:49201) Anti-Ulcer Agents (Code: D000897) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) | 1977-08-16 FDA | |
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| cioteronel | None | |
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| cinoxacin | DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) | Synthetic antimicrobial related to OXOLINIC ACID and NALIDIXIC ACID and used in URINARY TRACT INFECTIONS. | antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1980-06-13 FDA | |
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| pyricarbate | A drug that has been given by mouth in the treatment of atherosclerosis and other vascular disorders, hyperlipidemias, and thrombo-embolic disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1408) | |
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| penciclovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) Thymidine kinase (Organism: Cercopithecine herpesvirus 1, class: Kinase, accessions: A3RLP8, gene: UL23, swissprot: A3RLP8_CHV1) Thymidine kinase (Organism: Human herpesvirus 1, class: Kinase, accessions: Q9QNF7, gene: TK, swissprot: KITH_HHV1) | The antiviral compound penciclovir has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, the viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted by cellular kinases to the active form penciclovir triphosphate. Biochemical studies demonstrate that penciclovir triphosphate inhibits HSV polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited. | DNA Polymerase Inhibitors (Code: N0000020060) Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000175468) Nucleoside Analog (Code: N0000175459) antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1996-09-24 FDA | 1KI3 |
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| triamterene | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Caspase-1 (Organism: Homo sapiens, class: Enzyme, accessions: P29466, gene: CASP1, swissprot: CASP1_HUMAN) Cathepsin G (Organism: Homo sapiens, class: Enzyme, accessions: P08311, gene: CTSG, swissprot: CATG_HUMAN) Pteridine reductase 1 (Organism: Leishmania major, class: Enzyme, accessions: Q01782, gene: PTR1, swissprot: PTR1_LEIMA) Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) Amiloride-sensitive sodium channel, ENaC (Organism: Homo sapiens, class: Ion channel, accessions: P37088|P51168|P51170, gene: SCNN1A|SCNN1B|SCNN1G, swissprot: SCNNA_HUMAN|SCNNB_HUMAN|SCNNG_HUMAN) | A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. | Decreased Renal K+ Excretion (Code: N0000008859) Increased Diuresis (Code: N0000175359) Potassium-sparing Diuretic (Code: N0000175418) diuretic (Code: CHEBI:35498) Diuretics (Code: D004232) Epithelial Sodium Channel Blockers (Code: D062686) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Channel Blockers (Code: D026941) | 1964-08-10 FDA | 3JQ7 |
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| actinoquinol | radiation protectant | |
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| sulfamethoxazole | Bifunctional protein FolC (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P08192, gene: folC, swissprot: FOLC_ECOLI) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Endothelin-1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P26684, gene: Ednra, swissprot: EDNRA_RAT) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) | Sulfonamide Antimicrobial (Code: N0000175504) Sulfonamides (Code: N0000008048) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) drug allergen (Code: CHEBI:88188) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) | 1973-07-30 FDA | 3TZF |
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| ethacridine | Telomerase reverse transcriptase (Organism: Homo sapiens, class: Enzyme, accessions: O14746, gene: TERT, swissprot: TERT_HUMAN) | A topically applied anti-infective agent. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | |
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| nepafenac | Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | penetrates the cornea and is converted by ocular tissue hydrolases to amfenac, a nonsteroidal anti-inflammatory drug, amfenac is thought to inhibit the action of prostaglandin H synthase (cyclooxygenase), an enzyme required for prostaglandin production | Cyclooxygenase Inhibitors (Code: N0000000160) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) prodrug (Code: CHEBI:50266) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2005-08-19 FDA | |
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| vanitiolide | None | |
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| meladrazine | None | |
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| tolpropamine | None | |
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| tizanidine | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | Tizanidine is an agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. | Adrenergic alpha2-Agonists (Code: N0000009918) Central alpha-2 Adrenergic Agonist (Code: N0000175554) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) Analgesics (Code: D000700) alpha-adrenergic agonist (Code: CHEBI:35569) muscle relaxant (Code: CHEBI:51371) Anticonvulsants (Code: D000927) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1996-11-27 FDA | |
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| proguanil | Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium vivax, class: Enzyme, accessions: O02604, gene: None, swissprot: DRTS_PLAVI) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium malariae, class: Enzyme, accessions: Q0IJY2, gene: None, swissprot: Q0IJY2_PLAMA) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium falciparum, class: Enzyme, accessions: P13922, gene: None, swissprot: DRTS_PLAFK) | A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. | Dihydrofolate Reductase Inhibitors (Code: N0000000191) antimalarial (Code: CHEBI:38068) antiprotozoal drug (Code: CHEBI:35820) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antimetabolites (Code: D000963) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Noxae (Code: D009676) | 2000-07-14 FDA | |
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| dichlorophenarsine | None | |
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| iodothiouracil | None | |
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| cinromide | None | |
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| diprophylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) | A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis. | bronchodilator agent (Code: CHEBI:35523) vasodilator agent (Code: CHEBI:35620) muscle relaxant (Code: CHEBI:51371) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Phosphodiesterase Inhibitors (Code: D010726) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) | 1951-03-07 FDA | 2X0Y |
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| menadione sodium bisulfite | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) | A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. | 4NMF |
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| ketoprofen | Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) | An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1986-01-09 FDA | |
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| fenbufen | Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | an orally active nonsteroidal anti-inflammatory drug with analgesic and antipyretic activity | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| dexketoprofen | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| midodrine | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Heat shock protein HSP 90-alpha (Organism: Homo sapiens, class: Cytosolic other, accessions: P07900, gene: HSP90AA1, swissprot: HS90A_HUMAN) | An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) prodrug (Code: CHEBI:50266) alpha-adrenergic agonist (Code: CHEBI:35569) sympathomimetic agent (Code: CHEBI:35524) vasoconstrictor agent (Code: CHEBI:50514) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1996-09-06 FDA | |
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| levorphanol | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) Sigma non-opioid intracellular receptor 1 (Organism: Mus musculus, class: Membrane receptor, accessions: O55242, gene: Sigmar1, swissprot: SGMR1_MOUSE) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) | A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1953-01-08 FDA | |
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| sulfadicramide | None | |
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| thiamylal | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) | A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919) | Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | None FDA | |
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| bucricaine | None | |
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| phenbenzamine | None | |
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| tripelennamine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Anti-Allergic Agents (Code: D018926) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1948-02-19 FDA | |
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| pilsicainide | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) | |
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| butanilicaine | None | local anaesthetic (Code: CHEBI:36333) | |
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| ganciclovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) Thymidine kinase (Organism: Human herpesvirus 1, class: Kinase, accessions: Q9QNF7, gene: TK, swissprot: KITH_HHV1) Purine nucleoside phosphorylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WP01, gene: punA, swissprot: PUNA_MYCTU) Capsid scaffolding protein (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P10210, gene: UL26, swissprot: SCAF_HHV11) Metabotropic glutamate receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P41594, gene: GRM5, swissprot: GRM5_HUMAN) Metabotropic glutamate receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q13255, gene: GRM1, swissprot: GRM1_HUMAN) | An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000175461) DNA Polymerase Inhibitors (Code: N0000020060) Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antiviral (Code: N0000175466) antiviral drug (Code: CHEBI:36044) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1989-06-23 FDA | 1KI2 4DA6 |
|
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| pranoprofen | Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63921, gene: Ptgs1, swissprot: PGH1_RAT) | None | |
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| ketorolac | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Prostaglandin-H2 D-isomerase (Organism: Mus musculus, class: Enzyme, accessions: O09114, gene: Ptgds, swissprot: PTGDS_MOUSE) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Cyclooxygenase Inhibitor (Code: N0000175939) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) analgesic (Code: CHEBI:35480) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1989-11-30 FDA | 4GRK |
|
|
| tenonitrozole | None | |
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| cetoxime | None | 1961-04-22 YEAR INTRODUCED | |
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| metralindole | None | |
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| thiazosulfone | None | |
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| sulfathiazole | Endothelin-1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P26684, gene: Ednra, swissprot: EDNRA_RAT) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) | antimicrobial; veterinary use against staphylococcal, streptococcal, pasteurella, and shigella infections; RN given refers to parent cpd; structure | antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) | 1945-09-12 FDA | 3TYE 4J7U 5CP3 5G44 |
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| tofenacin | None | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neurotransmitter Agents (Code: D018377) | None UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| phenyltoloxamine | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | None FDA | |
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| diphenhydramine | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) | A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) antiemetic (Code: CHEBI:50919) sedative (Code: CHEBI:35717) anti-allergic agent (Code: CHEBI:50857) muscarinic antagonist (Code: CHEBI:48876) antiparkinson drug (Code: CHEBI:48407) antipruritic drug (Code: CHEBI:59683) local anaesthetic (Code: CHEBI:36333) antidyskinesia agent (Code: CHEBI:66956) antitussive (Code: CHEBI:51177) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Sleep Aids, Pharmaceutical (Code: D000068776) | 1946-03-04 FDA | 2AOT |
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| atomoxetine | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Kir3.1/Kir3.2 (Organism: Homo sapiens, class: Ion channel, accessions: P48051|P48549, gene: KCNJ3|KCNJ6, swissprot: KCNJ3_HUMAN|KCNJ6_HUMAN) Kir3.1/Kir3.4 (Organism: Homo sapiens, class: Ion channel, accessions: P48544|P48549, gene: KCNJ3|KCNJ5, swissprot: KCNJ3_HUMAN|KCNJ5_HUMAN) G protein-activated inward rectifier potassium channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: P48051, gene: KCNJ6, swissprot: KCNJ6_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Krueppel-like factor 10 (Organism: Homo sapiens, class: Unclassified, accessions: Q13118, gene: KLF10, swissprot: KLF10_HUMAN) | A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. | Norepinephrine Reuptake Inhibitor (Code: N0000175695) Norepinephrine Uptake Inhibitors (Code: N0000000102) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) adrenergic uptake inhibitor (Code: CHEBI:35640) antidepressant (Code: CHEBI:35469) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 2002-11-26 FDA | |
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| dimemorfan | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| clobutinol | was minor as SILOMAT mapped to AMINO ALCOHOLS (63-79) | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| anagrelide | cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) cGMP-dependent 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O00408, gene: PDE2A, swissprot: PDE2A_HUMAN) | imidazoquinazoline derivative which lowers platelet count probably by inhibiting thrombopoiesis and reduces platelet aggregation; used for thrombocythemia | Decreased Platelet Production (Code: N0000175972) Platelet-reducing Agent (Code: N0000175638) Phosphodiesterase 3 Inhibitors (Code: N0000175086) anticoagulant (Code: CHEBI:50249) platelet aggregation inhibitor (Code: CHEBI:50427) antifibrinolytic drug (Code: CHEBI:48675) cardiovascular drug (Code: CHEBI:35554) Cardiovascular Agents (Code: D002317) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | 1997-03-14 FDA | |
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| lamotrigine | Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel protein type 8 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UQD0, gene: SCN8A, swissprot: SCN8A_HUMAN) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type X alpha subunit (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62968, gene: Scn10a, swissprot: SCNAA_RAT) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) | blocks voltage-gated sodium and calcium channels and inhibits release of excitatory neurotransmitters such as glutamate; structure given in first source | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Mood Stabilizer (Code: N0000175751) anticonvulsant (Code: CHEBI:35623) antimanic drug (Code: CHEBI:35477) antidepressant (Code: CHEBI:35469) non-narcotic analgesic (Code: CHEBI:35481) Anticonvulsants (Code: D000927) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1994-12-27 FDA | |
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| tiaprofenic acid | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| irsogladine | None | Anti-Ulcer Agents (Code: D000897) Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Gastrointestinal Agents (Code: D005765) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) | |
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| phenyl acetylsalicylate | None | |
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| edoxudine | Thymidine kinase (Organism: Cercopithecine herpesvirus 1, class: Kinase, accessions: A3RLP8, gene: UL23, swissprot: A3RLP8_CHV1) | None | |
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| phenosulfazole | None | |
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| etoxazene | None | None FDA | |
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| phenbutamide | None | |
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| echothiophate | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. | Cholinesterase Inhibitor (Code: N0000175723) Iodine (Code: N0000007196) miotic (Code: CHEBI:51068) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Miotics (Code: D008916) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 1960-06-27 FDA | |
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| bephenium | None | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | |
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| hexyldecanoic acid | viscous oil | |
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| pyrrolnitrin | 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium. | antifungal drug (Code: CHEBI:86327) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| benzamidosalicylate | None | |
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| benserazide | Aromatic-L-amino-acid decarboxylase (Organism: Homo sapiens, class: Enzyme, accessions: P20711, gene: DDC, swissprot: DDC_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) SUMO-activating enzyme (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBE0|Q9UBT2, gene: SAE1|UBA2, swissprot: SAE1_HUMAN|SAE2_HUMAN) Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone. | antiparkinson drug (Code: CHEBI:48407) dopaminergic agent (Code: CHEBI:48560) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) | 1990-01-01 YEAR INTRODUCED | |
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| carmofur | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Acid ceramidase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q6P7S1, gene: Asah1, swissprot: ASAH1_RAT) | None | Antineoplastic Agents (Code: D000970) | |
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| tolmetin | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Interleukin-8 (Organism: Homo sapiens, class: Cytokine, accessions: P10145, gene: CXCL8, swissprot: IL8_HUMAN) Lactoylglutathione lyase (Organism: Homo sapiens, class: Enzyme, accessions: Q04760, gene: GLO1, swissprot: LGUL_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1976-03-24 FDA | 3S3G |
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| etebenecid | None | |
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| medifoxamine | None | |
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| suprofen | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) | An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) peripheral nervous system drug (Code: CHEBI:49110) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1988-12-23 FDA | |
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| metrifonate | An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed) | Anthelmintics (Code: D000871) insecticide (Code: CHEBI:24852) agrochemical (Code: CHEBI:33286) anthelminthic drug (Code: CHEBI:35443) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Insecticides (Code: D007306) Neurotransmitter Agents (Code: D018377) Pesticides (Code: D010575) | |
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| meclofenoxate | An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. | Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Nootropic Agents (Code: D018697) Protective Agents (Code: D020011) | |
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| iodinated glycerol | secretolytic agent; RN given refers to cpd without iodine locant | |
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| aceglatone | None | |
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| salsalate | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) hypoglycemic agent (Code: CHEBI:35526) antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| glycerylphosphorylcholine | A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed) | |
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| choline alfoscerate | None | parasympatholytic (Code: CHEBI:50370) neuroprotective agent (Code: CHEBI:63726) | |
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| thalidomide | Protein cereblon (Organism: Homo sapiens, class: Cytosolic other, accessions: Q96SW2, gene: CRBN, swissprot: CRBN_HUMAN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Tumor necrosis factor (Organism: Homo sapiens, class: Cytokine, accessions: P01375, gene: TNF, swissprot: TNFA_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. | Decreased Immunologically Active Molecule Activity (Code: N0000008663) Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) immunosuppressive agent (Code: CHEBI:35705) leprostatic drug (Code: CHEBI:35816) angiogenesis inhibitor (Code: CHEBI:48422) anticonvulsant (Code: CHEBI:35623) antiemetic (Code: CHEBI:50919) sedative (Code: CHEBI:35717) anti-inflammatory drug (Code: CHEBI:35472) antineoplastic agent (Code: CHEBI:35610) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Leprostatic Agents (Code: D007917) Noxae (Code: D009676) Teratogens (Code: D013723) | 1998-07-16 FDA | 4CI1 4TZC 4V2Y 4V32 5AMH 5AMI 5AMJ 5AMK 5YIZ 5YJ0 5YJ1 |
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| acadesine | None | platelet aggregation inhibitor (Code: CHEBI:50427) antineoplastic agent (Code: CHEBI:35610) | |
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| menbutone | None | |
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| phethenylate | None | |
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| lenalidomide | Protein cereblon (Organism: Homo sapiens, class: Cytosolic other, accessions: Q96SW2, gene: CRBN, swissprot: CRBN_HUMAN) Tumor necrosis factor (Organism: Homo sapiens, class: Cytokine, accessions: P01375, gene: TNF, swissprot: TNFA_HUMAN) | Lenalidomide is an analogue of thalidomide with immunomodulatory, antiangiogenic, and antineoplastic properties. Lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including multiple myeloma, mantle cell lymphoma, and del (5q) myelodysplastic syndromes in vitro. Lenalidomide causes a delay in tumor growth in some in vivo nonclinical hematopoietic tumor models including multiple myeloma. Immunomodulatory properties of lenalidomide include activation of T cells and natural killer (NK) cells, increased numbers of NKT cells, and inhibition of pro-inflammatory cytokines (e.g., TNF-alpha and IL-6) by monocytes. In multiple myeloma cells, the combination of lenalidomide and dexamethasone synergizes the inhibition of cell proliferation and the induction of apoptosis. | Thalidomide Analog (Code: N0000184014) Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) angiogenesis inhibitor (Code: CHEBI:48422) antineoplastic agent (Code: CHEBI:35610) immunomodulator (Code: CHEBI:50846) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) Immunologic Factors (Code: D007155) | 2005-12-27 FDA | 4CI2 4TZ4 4V30 5FQD |
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| ethoxzolamide | Carbonic anhydrase 3 (Organism: Bos taurus, class: Enzyme, accessions: Q3SZX4, gene: CA3, swissprot: CAH3_BOVIN) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Carbonic anhydrase V (Organism: Homo sapiens, class: Enzyme, accessions: P35218|Q9Y2D0, gene: CA5A|CA5B, swissprot: CAH5A_HUMAN|CAH5B_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. | diuretic (Code: CHEBI:35498) antiglaucoma drug (Code: CHEBI:39456) Carbonic Anhydrase Inhibitors (Code: D002257) Diuretics (Code: D004232) Enzyme Inhibitors (Code: D004791) Natriuretic Agents (Code: D045283) | None FDA | 3CAJ 3DCW 3DD0 3MDZ 5JN9 5TT3 6BCC |
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| xibornol | None | antibacterial drug (Code: CHEBI:36047) | |
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| cloridarol | None | |
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| pamabrom | Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) | None | None FDA | |
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| lofexidine | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | reduces narcotic withdrawal symptoms; RN given refers to parent cpd without isomeric designation; structure in Negwer, 5th ed, #6247 | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) alpha-adrenergic agonist (Code: CHEBI:35569) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| mizoribine | imidazole nucleoside with immunosuppressive activity isolated from culture filtrate of Eupenicillium brefeldianum; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antibiotics, Antineoplastic (Code: D000903) Antimalarials (Code: D000962) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 3B1N |
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| ramelteon | Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) | Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 and MT2 receptors and selectivity over the MT3 receptor. Ramelteon demonstrates full agonist activity in vitro in cells expressing human MT1 or MT2 receptors. The activity of ramelteon at the MT1 and MT2 receptors is believed to contribute to its sleep-promoting properties, as these receptors, acted upon by endogenous melatonin, are thought to be involved in the maintenance of the circadian rhythm underlying the normal sleep-wake cycle. | Melatonin Receptor Agonist (Code: N0000175743) Melatonin Receptor Agonists (Code: N0000000250) | 2005-07-22 FDA | |
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| propranolol | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) antihypertensive agent (Code: CHEBI:35674) beta-adrenergic antagonist (Code: CHEBI:35530) anxiolytic drug (Code: CHEBI:35474) anti-arrhythmia drug (Code: CHEBI:38070) vasodilator agent (Code: CHEBI:35620) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 1967-11-13 FDA | 1DY4 5FUK |
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| flumequine | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Renal Agents (Code: D012076) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| primaquine | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Chloroquine resistance transporter (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q9N623, gene: CRT, swissprot: CRT_PLAFA) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Heat shock protein HSP 90-alpha (Organism: Homo sapiens, class: Cytosolic other, accessions: P07900, gene: HSP90AA1, swissprot: HS90A_HUMAN) Hemoglobin subunit alpha (Organism: Homo sapiens, class: Secreted, accessions: P69905, gene: HBA1, swissprot: HBA_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Aryl hydrocarbon receptor (Organism: Homo sapiens, class: Transcription factor, accessions: P35869, gene: AHR, swissprot: AHR_HUMAN) Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404) | antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | 1952-01-23 FDA | 4FGJ |
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| eperisone | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) | None | muscle relaxant (Code: CHEBI:51371) Anticonvulsants (Code: D000927) Autonomic Agents (Code: D001337) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Vasodilator Agents (Code: D014665) | |
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| azintamide | None | |
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| clobenzorex | None | |
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| carbarsone | sometimes used in treatment of intestinal amoebiasis | |
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| glucose-1-phosphate | None | 1G0R 1G23 1H5R 1L5V 1NT4 1P5D 1UXQ 1UXT 2B0C 2UX8 2WF8 3BKQ 3GPB 4HO4 4L97 5BMP 5H42 5IN3 |
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| khellin | A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024) | vasodilator agent (Code: CHEBI:35620) bronchodilator agent (Code: CHEBI:35523) anti-asthmatic agent (Code: CHEBI:65023) cardiovascular drug (Code: CHEBI:35554) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) | |
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| tiazofurine | None | prodrug (Code: CHEBI:50266) antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | 2P0E 2QL6 |
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| phetharbital | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | |
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| carisoprodol | A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202) | Centrally-mediated Muscle Relaxation (Code: N0000175730) muscle relaxant (Code: CHEBI:51371) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | 1959-04-09 FDA | |
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| fenspiride | None | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| imolamine | blood platelet aggregation antagonist; RN given refers to parent cpd; structure | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| ropinirole | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | Ropinirole is a non-ergoline dopamine agonist. The precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, although it is thought to be related to its ability to stimulate dopamine D2 receptors within the caudate-putamen in the brain. | Nonergot Dopamine Agonist (Code: N0000175768) dopamine agonist (Code: CHEBI:51065) central nervous system drug (Code: CHEBI:35470) antidyskinesia agent (Code: CHEBI:66956) antiparkinson drug (Code: CHEBI:48407) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | 1997-09-19 FDA | |
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| oxymetazoline | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Alpha-2 adrenergic receptor (Organism: Mus musculus, class: GPCR, accessions: P30545|Q01337|Q01338, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_MOUSE|ADA2B_MOUSE|ADA2C_MOUSE) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-2A adrenergic receptor (Organism: Sus scrofa, class: GPCR, accessions: P18871, gene: ADRA2A, swissprot: ADA2A_PIG) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | Imidazoline derivative with sympathomimetic activity that stimulates alpha-adrenergic receptors in the arterioles of the nasal mucosa to produce vasoconstriction. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) alpha-adrenergic agonist (Code: CHEBI:35569) sympathomimetic agent (Code: CHEBI:35524) nasal decongestant (Code: CHEBI:77715) vasoconstrictor agent (Code: CHEBI:50514) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Vasoconstrictor (Code: N0000192562) Vasoconstriction (Code: N0000009908) Increased Sympathetic Activity (Code: N0000175651) Imidazolines (Code: N0000011304) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | 1986-05-30 FDA | |
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| methaphenilene | None | |
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| ifosfamide | Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1988-12-30 FDA | |
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| trimetazidine | Carnitine O-palmitoyltransferase 1, muscle isoform (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63704, gene: Cpt1b, swissprot: CPT1B_RAT) | A vasodilator used in angina of effort or ischemic heart disease. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1978-01-01 YEAR INTRODUCED | |
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| cyclophosphamide | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. | Alkylating Agents (Code: D000477) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Antirheumatic Agents (Code: D018501) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Mutagens (Code: D009153) Myeloablative Agonists (Code: D019653) Noxae (Code: D009676) | 1959-11-16 FDA | |
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| oxolinic acid | Synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS. | antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Renal Agents (Code: D012076) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| benznidazole | Benznidazole inhibits the synthesis of DNA, RNA, and proteins within the T. cruzi parasite. Studies suggest that benznidazole is reduced by a Type I nitroreductase (NTR) enzyme of T. cruzi producing a series of short-lived intermediates that may promote damage to several macromolecules including DNA. In mammalian cells, however, benznidazole is metabolized by reduction of the nitro group to an amino group by a Type II NTR enzyme. The precise mechanism of action is not known. Benznidazole is active against all three stages, trypomastigotes, amastigotes, and epimastigotes, of T. cruzi. However, the sensitivity of T. cruzi strains to benznidazole, from different geographic regions, may vary. | antiprotozoal drug (Code: CHEBI:35820) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Mutagens (Code: D009153) Noxae (Code: D009676) Trypanocidal Agents (Code: D014344) | 2017-08-29 FDA | |
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| etoxadrol | Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) | None | |
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| hexylcaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | None FDA | |
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| ethoheptazine | major descriptor (65-83); on-line search AZEPINES (65-83); Index Medicus search ETHOHEPTAZINE (65-83); RN given refers to parent cpd; structure | |
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| bufuralol | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | |
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| etoglucid | Alkylating antineoplastic agent used especially in bladder neoplasms. It is toxic to hair follicles, gastro-intestinal tract, and vasculature. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| dimethylthiambutene | None | opioid analgesic (Code: CHEBI:35482) | |
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| alphaprodine | An opioid analgesic chemically related to and with an action resembling that of MEPERIDINE, but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067) | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| setiptiline | None | |
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| phenindamine | Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| methapyrilene | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) | Histamine H1 antagonist with sedative action used as a hypnotic and in allergies. | Anti-Allergic Agents (Code: D018926) anti-allergic agent (Code: CHEBI:50857) sedative (Code: CHEBI:35717) H1-receptor antagonist (Code: CHEBI:37955) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | |
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| amixetrine | None | |
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| tolfenamic acid | Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Prostaglandin Antagonists (Code: D011448) Sensory System Agents (Code: D018689) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1976-01-01 YEAR INTRODUCED | 4G77 5IKT 6AP6 |
|
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| reposal | None | |
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| methohexital | Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|Q15822, gene: CHRNA2|CHRNB2, swissprot: ACHA2_HUMAN|ACHB2_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. | Barbiturate (Code: N0000175693) Barbiturates (Code: N0000008016) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) intravenous anaesthetic (Code: CHEBI:38877) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 1960-06-27 FDA | |
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| benzylsulfamide | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) | None | |
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| fencibutirol | None | |
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| homosalate | cpd not photoallergenic | Cosmetics (Code: D003358) Dermatologic Agents (Code: D003879) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) Sunscreening Agents (Code: D013473) | None FDA | |
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| mepindolol | 2-methyl deriv of pindolol; RN given refers to parent cpd; structure | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | |
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| cibenzoline | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) ATP-sensitive inward rectifier potassium channel 11 (Organism: Homo sapiens, class: Ion channel, accessions: Q14654, gene: KCNJ11, swissprot: KCJ11_HUMAN) | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | 1978-01-01 YEAR INTRODUCED | |
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| clonixin | Anti-inflammatory analgesic. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) platelet aggregation inhibitor (Code: CHEBI:50427) vasodilator agent (Code: CHEBI:35620) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 5L4I |
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| ticlopidine | P2Y purinoceptor 12 (Organism: Homo sapiens, class: GPCR, accessions: Q9H244, gene: P2RY12, swissprot: P2Y12_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Cytochrome P450 2A6 (Organism: Homo sapiens, class: Enzyme, accessions: P11509, gene: CYP2A6, swissprot: CP2A6_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Cytochrome P450 2B6 (Organism: Homo sapiens, class: Enzyme, accessions: P20813, gene: CYP2B6, swissprot: CP2B6_HUMAN) | An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. | Decreased Platelet Aggregation (Code: N0000008832) fibrin modulating drug (Code: CHEBI:48676) hematologic agent (Code: CHEBI:50248) platelet aggregation inhibitor (Code: CHEBI:50427) anticoagulant (Code: CHEBI:50249) Cardiovascular Agents (Code: D002317) Cytochrome P-450 CYP2C19 Inhibitors (Code: D065689) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) Platelet Aggregation Inhibitors (Code: D010975) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P2 Receptor Antagonists (Code: D058919) Purinergic P2Y Receptor Antagonists (Code: D058921) | 1991-10-31 FDA | 3KW4 |
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| gemcitabine | UMP-CMP kinase (Organism: Homo sapiens, class: Kinase, accessions: P30085, gene: CMPK1, swissprot: KCY_HUMAN) Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) DNA polymerase (alpha/delta/epsilon) (Organism: Homo sapiens, class: Enzyme, accessions: P09884|P28340|Q07864, gene: POLA1|POLD1|POLE, swissprot: DPOD1_HUMAN|DPOE1_HUMAN|DPOLA_HUMAN) Ribonucleoside-diphosphate reductase subunit M2 (Organism: Homo sapiens, class: Enzyme, accessions: P31350, gene: RRM2, swissprot: RIR2_HUMAN) Ribonucleoside-diphosphate reductase large subunit (Organism: Homo sapiens, class: Enzyme, accessions: P23921, gene: RRM1, swissprot: RIR1_HUMAN) Deoxycytidine kinase (Organism: Homo sapiens, class: Kinase, accessions: P27707, gene: DCK, swissprot: DCK_HUMAN) | Gemcitabine kills cells undergoing DNA synthesis and blocks the progression of cells through the G1/S-phase boundary. Gemcitabine is metabolized by nucleoside kinases to diphosphate (dFdCDP) and triphosphate (dFdCTP) nucleosides. Gemcitabine diphosphate inhibits ribonucleotide reductase, an enzyme responsible for catalyzing the reactions that generate deoxynucleoside triphosphates for DNA synthesis, resulting in reductions in deoxynucleotide concentrations, including dCTP. Gemcitabine triphosphate competes with dCTP for incorporation into DNA. The reduction in the intracellular concentration of dCTP by the action of the diphosphate enhances the incorporation of gemcitabine triphosphate into DNA (selfpotentiation). After the gemcitabine nucleotide is incorporated into DNA, only one additional nucleotide is added to the growing DNA strands, which eventually results in the initiation of apoptotic cell death. | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) photosensitizing agent (Code: CHEBI:47868) radiosensitizing agent (Code: CHEBI:132992) prodrug (Code: CHEBI:50266) antineoplastic agent (Code: CHEBI:35610) antiviral drug (Code: CHEBI:36044) immunosuppressive agent (Code: CHEBI:35705) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) Radiation-Sensitizing Agents (Code: D011838) | 1996-05-15 FDA | 1P62 2NO0 2VPP 4PD5 |
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| miloxacin | None | |
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| hydroxypethidine | None | |
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| melperone | 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | 1972-01-01 YEAR INTRODUCED | |
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| tramadol | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) | A narcotic analgesic proposed for severe pain. It may be habituating. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) adrenergic uptake inhibitor (Code: CHEBI:35640) muscarinic antagonist (Code: CHEBI:48876) opioid analgesic (Code: CHEBI:35482) antitussive (Code: CHEBI:51177) mu-opioid receptor agonist (Code: CHEBI:55322) kappa-opioid receptor agonist (Code: CHEBI:59282) serotonin uptake inhibitor (Code: CHEBI:50949) serotonergic antagonist (Code: CHEBI:48279) nicotinic antagonist (Code: CHEBI:48878) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1995-03-03 FDA | |
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| butetamate | None | |
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| protriptyline | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1967-09-27 FDA | |
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| nortriptyline | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) ATP-sensitive inward rectifier potassium channel 10 (Organism: Homo sapiens, class: Ion channel, accessions: P78508, gene: KCNJ10, swissprot: KCJ10_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) antidepressant (Code: CHEBI:35469) adrenergic uptake inhibitor (Code: CHEBI:35640) analgesic (Code: CHEBI:35480) antineoplastic agent (Code: CHEBI:35610) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1964-11-06 FDA | 4M48 |
|
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| sulfamerazine | Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | A sulfanilamide that is used as an antibacterial agent. | antiinfective agent (Code: CHEBI:35441) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1949-08-16 FDA | |
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| propacetamol | prodrug for acetaminophen | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| etaqualone | None | |
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| pentifylline | None | |
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| thialbarbital | None | |
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| tetracaine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) cGMP-gated cation channel alpha-1 (Organism: Bos taurus, class: Ion channel, accessions: Q00194, gene: CNGA1, swissprot: CNGA1_BOVIN) | Local ester anesthetic that blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, which results in inhibition of depolarization with resultant blockade of conduction. | Ester Local Anesthetic (Code: N0000175683) Esters (Code: N0000166743) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2005-06-23 FDA | 4OMW 4Y0P |
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| mianserin | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Rattus norvegicus, class: GPCR, accessions: P08911, gene: Chrm5, swissprot: ACM5_RAT) Serotonin 3 receptor (5HT3) (Organism: Mus musculus, class: Ion channel, accessions: P23979|Q9JHJ5, gene: Htr3a|Htr3b, swissprot: 5HT3A_MOUSE|5HT3B_MOUSE) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Cerebral cortex alpha adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130|Q28838, gene: ADRA1A|ADRA2A, swissprot: ADA1A_BOVIN|ADA2A_BOVIN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) G-protein coupled receptor (Organism: Apis mellifera, class: Unclassified, accessions: Q9NG02, gene: tyr1, swissprot: Q9NG02_APIME) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) 5-hydroxytryptamine receptor 1B (Organism: Mus musculus, class: Unclassified, accessions: P28334, gene: Htr1b, swissprot: 5HT1B_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) | A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) antidepressant (Code: CHEBI:35469) sedative (Code: CHEBI:35717) alpha-adrenergic antagonist (Code: CHEBI:37890) adrenergic uptake inhibitor (Code: CHEBI:35640) serotonergic antagonist (Code: CHEBI:48279) histamine agonist (Code: CHEBI:35678) H1-receptor antagonist (Code: CHEBI:37955) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1976-01-01 YEAR INTRODUCED | |
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| antazoline | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | An ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles. These histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Antazoline is used to provide symptomatic relieve of allergic symptoms. | Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) cholinergic antagonist (Code: CHEBI:48873) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1990-04-30 FDA | |
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| sulfiram | None | |
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| streptozocin | An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) antineoplastic agent (Code: CHEBI:35610) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) | 1982-05-07 FDA | 2W4X |
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| oxycinchophen | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y233, gene: PDE10A, swissprot: PDE10_HUMAN) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q02127, gene: DHODH, swissprot: PYRD_HUMAN) | None | |
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| albendazole | Tubulin alpha chain (Organism: Haemonchus contortus, class: Structural, accessions: P50719, gene: None, swissprot: TBA_HAECO) Tubulin (Organism: Echinococcus granulosus, class: Structural, accessions: C4PKY4|C4PKZ2|C4PKZ6, gene: None, swissprot: C4PKY4_ECHGR|C4PKZ2_ECHGR|C4PKZ6_ECHGR) Tubulin (Organism: Ascaris suum, class: Structural, accessions: F1L005|F1L4P8|F1L5G6|F1L7U3|F1L7Y0|F1L8A5|F1LCS0, gene: None, swissprot: F1L005_ASCSU|F1L4P8_ASCSU|F1L5G6_ASCSU|F1L7U3_ASCSU|F1L7Y0_ASCSU|F1L8A5_ASCSU|F1LCS0_ASCSU) | A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Antihelminthic (Code: N0000175481) Anthelmintics (Code: D000871) anthelminthic drug (Code: CHEBI:35443) Anti-Infective Agents (Code: D000890) Anticestodal Agents (Code: D000923) Antimitotic Agents (Code: D050256) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Antiprotozoal Agents (Code: D000981) Mitosis Modulators (Code: D050258) Cytochrome P450 1A Inducers (Code: N0000191624) Tubulin Modulators (Code: D050257) | 1996-06-11 FDA | |
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| parethoxycaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | |
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| oxprenolol | Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Anxiety Agents (Code: D014151) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sympatholytics (Code: D013565) Tranquilizing Agents (Code: D014149) Vasodilator Agents (Code: D014665) | None FDA | |
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| mirtazapine | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | esmirtazapine is the maleate salt of the (S(+))-isomer | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) alpha-adrenergic antagonist (Code: CHEBI:37890) serotonergic antagonist (Code: CHEBI:48279) histamine antagonist (Code: CHEBI:37956) anxiolytic drug (Code: CHEBI:35474) H1-receptor antagonist (Code: CHEBI:37955) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) | 1996-06-14 FDA | |
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| thiamine | Heat shock protein HSP 90-alpha (Organism: Homo sapiens, class: Cytosolic other, accessions: P07900, gene: HSP90AA1, swissprot: HS90A_HUMAN) Transketolase-like protein 1 (Organism: Homo sapiens, class: Enzyme, accessions: P51854, gene: TKTL1, swissprot: TKTL1_HUMAN) Thiamine-triphosphatase (Organism: Homo sapiens, class: Enzyme, accessions: Q9BU02, gene: THTPA, swissprot: THTPA_HUMAN) Thiamin pyrophosphokinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9H3S4, gene: TPK1, swissprot: TPK1_HUMAN) Transketolase (Organism: Homo sapiens, class: Enzyme, accessions: P29401, gene: TKT, swissprot: TKT_HUMAN) Thiamine transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O60779, gene: SLC19A2, swissprot: S19A2_HUMAN) | 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride. | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | 1993-12-29 FDA | 1IG0 1IG3 1SBR 2HH9 3LM8 3MYU 3RLB 4KYS 4NMY 4NYG 5EDL |
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| chloralodol | None | |
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| bropirimine | Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) | None | Adjuvants, Immunologic (Code: D000276) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Interferon Inducers (Code: D007369) | |
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| doxofylline | None | bronchodilator agent (Code: CHEBI:35523) antitussive (Code: CHEBI:51177) anti-asthmatic drug (Code: CHEBI:49167) Anti-Asthmatic Agents (Code: D018927) Antitussive Agents (Code: D000996) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Phosphodiesterase Inhibitors (Code: D010726) Respiratory System Agents (Code: D019141) | |
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| benzarone | Solute carrier family 22 member 12 (Organism: Homo sapiens, class: Transporter, accessions: Q96S37, gene: SLC22A12, swissprot: S22AC_HUMAN) | antihemorrhagic agent; structure | Cardiovascular Agents (Code: D002317) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) | |
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| nevirapine | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Reverse transcriptase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9WKE8, gene: reverse transcriptas, swissprot: Q9WKE8_9HIV1) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) | A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. | Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175463) Non-Nucleoside Analog (Code: N0000175460) Non-Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009948) Cytochrome P450 3A Inducers (Code: N0000190118) Cytochrome P450 2B6 Inducers (Code: N0000187064) antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Cytochrome P-450 CYP3A Inducers (Code: D065701) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1996-06-21 FDA | 1FKP 1JLB 1JLF 1LW0 1LWC 1LWE 1LWF 1S1U 1S1X 1VRT 2HND 2HNY 3HVT 3LP0 3LP1 3QIP 3V81 4B3Q 4PUO 4PWD 4Q0B 5HBM |
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| dienestrol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms. | xenoestrogen (Code: CHEBI:76988) Estrogens (Code: D004967) Estrogens, Non-Steroidal (Code: D004968) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1947-01-09 FDA | |
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| practolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-2 adrenergic receptor (Organism: Mus musculus, class: Unclassified, accessions: P18762, gene: Adrb2, swissprot: ADRB2_MOUSE) | A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) beta-adrenergic antagonist (Code: CHEBI:35530) anti-arrhythmia drug (Code: CHEBI:38070) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| atenolol | Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1981-08-19 FDA | 2NUV 2OTF 2OUB |
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| nordazepam | GABA-A receptor; anion channel (Organism: Mus musculus, class: Ion channel, accessions: A2AMW3|P16305|P22723|P22933|P26048|P26049|P27681|P50571|P62812|P63080|Q8BHJ7|Q8QZW7|Q9D6F4|Q9JLF1|Q9R0Y8, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: A2AMW3_MOUSE|GBRA1_MOUSE|GBRA2_MOUSE|GBRA3_MOUSE|GBRA4_MOUSE|GBRA5_MOUSE|GBRA6_MOUSE|GBRB1_MOUSE|GBRB3_MOUSE|GBRD_MOUSE|GBRG1_MOUSE|GBRG2_MOUSE|GBRG3_MOUSE|GBRP_MOUSE|GBRT_MOUSE) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Gamma-aminobutyric acid receptor subunit rho-2 (Organism: Homo sapiens, class: Ion channel, accessions: P28476, gene: GABRR2, swissprot: GBRR2_HUMAN) Gamma-aminobutyric acid type B receptor subunit 2 (Organism: Homo sapiens, class: GPCR, accessions: O75899, gene: GABBR2, swissprot: GABR2_HUMAN) | An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam. | Anti-Anxiety Agents (Code: D014151) anticonvulsant (Code: CHEBI:35623) sedative (Code: CHEBI:35717) GABA modulator (Code: CHEBI:50268) anxiolytic drug (Code: CHEBI:35474) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1961-01-01 YEAR INTRODUCED | |
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| desipramine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent serotonin transporter (Organism: Mus musculus, class: Transporter, accessions: Q60857, gene: Slc6a4, swissprot: SC6A4_MOUSE) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) G protein-activated inward rectifier potassium channel 4 (Organism: Mus musculus, class: Unclassified, accessions: P48545, gene: Kcnj5, swissprot: KCNJ5_MOUSE) Equilibrative nucleoside transporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q7RTT9, gene: SLC29A4, swissprot: S29A4_HUMAN) | A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) adrenergic uptake inhibitor (Code: CHEBI:35640) serotonin uptake inhibitor (Code: CHEBI:50949) cholinergic antagonist (Code: CHEBI:48873) alpha-adrenergic antagonist (Code: CHEBI:37890) H1-receptor antagonist (Code: CHEBI:37955) antidepressant (Code: CHEBI:35469) drug allergen (Code: CHEBI:88188) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1964-11-20 FDA | 2QB4 2QJU |
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| cyclizine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | antiemetic (Code: CHEBI:50919) cholinergic antagonist (Code: CHEBI:48873) central nervous system depressant (Code: CHEBI:35488) local anaesthetic (Code: CHEBI:36333) H1-receptor antagonist (Code: CHEBI:37955) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | None FDA | |
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| propenidazole | None | |
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| zidovudine | Thymidine kinase (Organism: Ureaplasma parvum serovar 3 (strain ATCC 700970), class: Unclassified, accessions: Q9PPP5, gene: tdk, swissprot: KITH_UREPA) Thymidylate kinase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WKE1, gene: tmk, swissprot: KTHY_MYCTU) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Thymidine kinase, cytosolic (Organism: Homo sapiens, class: Kinase, accessions: P04183, gene: TK1, swissprot: KITH_HUMAN) Gag-Pro-Pol polyprotein (Organism: Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A), class: Polyprotein, accessions: P03362, gene: gag-pro-pol, swissprot: POL_HTL1A) Thymidylate kinase (Organism: Homo sapiens, class: Kinase, accessions: P23919, gene: DTYMK, swissprot: KTHY_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72549, gene: pol, swissprot: Q72549_9HIV1) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Reverse transcriptase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9WKE8, gene: reverse transcriptas, swissprot: Q9WKE8_9HIV1) | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175462) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1987-03-19 FDA | 2JJ8 3B9L 3B9M 3BCR 4LHM |
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| vidarabine | Adenosylhomocysteinase (Organism: Mus musculus, class: Unclassified, accessions: P50247, gene: Ahcy, swissprot: SAHH_MOUSE) Adenylate cyclase type V (Organism: Rattus norvegicus, class: Enzyme, accessions: Q04400, gene: Adcy5, swissprot: ADCY5_RAT) Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) Ribose-phosphate pyrophosphokinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P60891, gene: PRPS1, swissprot: PRPS1_HUMAN) Deoxyguanosine kinase, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q16854, gene: DGUOK, swissprot: DGUOK_HUMAN) Ribonucleoside-diphosphate reductase subunit M2 (Organism: Homo sapiens, class: Enzyme, accessions: P31350, gene: RRM2, swissprot: RIR2_HUMAN) Ribonucleoside-diphosphate reductase large subunit (Organism: Homo sapiens, class: Enzyme, accessions: P23921, gene: RRM1, swissprot: RIR1_HUMAN) DNA polymerase alpha catalytic subunit (Organism: Homo sapiens, class: Enzyme, accessions: P09884, gene: POLA1, swissprot: DPOLA_HUMAN) Deoxycytidine kinase (Organism: Homo sapiens, class: Kinase, accessions: P27707, gene: DCK, swissprot: DCK_HUMAN) | A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus. | Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Noxae (Code: D009676) | 1976-11-26 FDA | 1PW7 3GLQ |
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| acetamidoeugenol | None | |
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| adenosine | Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) cAMP-dependent protein kinase A (Organism: Bos taurus, class: Unclassified, accessions: P00515|P00517|P05131|P31322, gene: PRKACA|PRKACB|PRKAR2A|PRKAR2B, swissprot: KAP2_BOVIN|KAP3_BOVIN|KAPCA_BOVIN|KAPCB_BOVIN) Adenosine kinase (Organism: Toxoplasma gondii, class: Kinase, accessions: Q9TVW2, gene: AK, swissprot: ADK_TOXGO) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) Adenosine A2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276|P30543, gene: Adora2a|Adora2b, swissprot: AA2AR_RAT|AA2BR_RAT) Glyceraldehyde-3-phosphate dehydrogenase liver (Organism: Homo sapiens, class: Enzyme, accessions: P04406, gene: GAPDH, swissprot: G3P_HUMAN) Adenosine receptor A3 (Organism: Rattus norvegicus, class: GPCR, accessions: P28647, gene: Adora3, swissprot: AA3R_RAT) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Adenosine deaminase (Organism: Homo sapiens, class: Enzyme, accessions: P00813, gene: ADA, swissprot: ADA_HUMAN) Adenosine kinase (Organism: Homo sapiens, class: Kinase, accessions: P55263, gene: ADK, swissprot: ADK_HUMAN) Adenosylhomocysteinase (Organism: Homo sapiens, class: Enzyme, accessions: P23526, gene: AHCY, swissprot: SAHH_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Phosphatidylinositol 4-kinase type 2-alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9BTU6, gene: PI4K2A, swissprot: P4K2A_HUMAN) Phosphatidylinositol 4-kinase type 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q8TCG2, gene: PI4K2B, swissprot: P4K2B_HUMAN) | A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. | Adenosine Receptor Agonist (Code: N0000178375) Adenosine Receptor Agonists (Code: N0000175788) Analgesics (Code: D000700) Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) vasodilator agent (Code: CHEBI:35620) analgesic (Code: CHEBI:35480) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Purinergic Agents (Code: D058905) Purinergic Agonists (Code: D058913) Purinergic P1 Receptor Agonists (Code: D058906) Sensory System Agents (Code: D018689) Vasodilator Agents (Code: D014665) | 1989-10-30 FDA | |
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| voglibose | Glycogen debranching enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P35574, gene: AGL, swissprot: GDE_RABIT) Lysosomal alpha-glucosidase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q6P7A9, gene: Gaa, swissprot: LYAG_RAT) Sucrase-isomaltase, intestinal (Organism: Rattus norvegicus, class: Enzyme, accessions: P23739, gene: Si, swissprot: SUIS_RAT) Lysosomal alpha-glucosidase (Organism: Homo sapiens, class: Enzyme, accessions: P10253, gene: GAA, swissprot: LYAG_HUMAN) | None | Enzyme Inhibitors (Code: D004791) Glycoside Hydrolase Inhibitors (Code: D065089) Hypoglycemic Agents (Code: D007004) | 1994-08-20 PMDA | 6C9X 6C9Z |
|
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| cafaminol | None | |
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| sulfafurazole | Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Plasmodium falciparum (isolate 3D7), class: Enzyme, accessions: Q08210, gene: None, swissprot: PYRD_PLAF7) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) Endothelin-1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P26684, gene: Ednra, swissprot: EDNRA_RAT) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) Endothelin B receptor (Organism: Homo sapiens, class: GPCR, accessions: P24530, gene: EDNRB, swissprot: EDNRB_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Sulfonamide Antimicrobial (Code: N0000175504) Sulfonamides (Code: N0000008048) antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) | 1971-06-07 FDA | |
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| sulfamoxole | A sulfanilamide antibacterial agent. | Anti-Infective Agents (Code: D000890) | |
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| apomorphine | Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(1A) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: Q61616, gene: Drd1, swissprot: DRD1_MOUSE) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) Mannose-6-phosphate isomerase (Organism: Homo sapiens, class: Enzyme, accessions: P34949, gene: MPI, swissprot: MPI_HUMAN) Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. | Dopaminergic Agonist (Code: N0000175580) antidyskinesia agent (Code: CHEBI:66956) antiparkinson drug (Code: CHEBI:48407) dopamine agonist (Code: CHEBI:51065) alpha-adrenergic drug (Code: CHEBI:48539) serotonergic drug (Code: CHEBI:48278) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Emetics (Code: D004639) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 2004-04-20 FDA | |
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| carbuterol | sympathomimetric specific for beta2 receptors; proposed bronchodilator agent; minor descriptor (78-86); on-line & INDEX MEDICUS search ETHANOLAMINES (78-86); RN given refers to parent cpd | |
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| metoprolol | Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) beta-adrenergic antagonist (Code: CHEBI:35530) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1978-08-07 FDA | |
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| razoxane | An antimitotic agent with immunosuppressive properties. | Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Mitosis Modulators (Code: D050258) | 1QZR |
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| azacyclonol | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | major descriptor (65-84); on-line search PIPERIDINES (65-84); Index Medicus search AZACYCLONOL (65-84); RN given refers to parent cpd | |
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| pipradrol | None | |
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| epervudine | None | |
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| chlornaphazine | None | |
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| nifurtoinol | None | antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | |
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| inosine | A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed) | None FDA | |
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| isoxepac | Non-steroidal arylacetic acid derivative anti-inflammatory with analgesic and antipyretic activity | |
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| pentostatin | Adenosine deaminase (Organism: Homo sapiens, class: Enzyme, accessions: P00813, gene: ADA, swissprot: ADA_HUMAN) Adenosine deaminase (Organism: Bos taurus, class: Enzyme, accessions: P56658, gene: ADA, swissprot: ADA_BOVIN) | A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Adenosine Deaminase Inhibitors (Code: D058892) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) | 1991-10-11 FDA | |
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| dexrazoxane | iron (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) | The (+)-enantiomorph of razoxane. | Cytoprotective Agent (Code: N0000180854) antineoplastic agent (Code: CHEBI:35610) cardiovascular drug (Code: CHEBI:35554) immunosuppressive agent (Code: CHEBI:35705) Antineoplastic Agents (Code: D000970) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1995-05-26 FDA | |
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| ripazepam | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) | None | |
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| diethylstilbestrol | Steroid hormone receptor ERR2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O95718, gene: ESRRB, swissprot: ERR2_HUMAN) Estrogen-related receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P62508, gene: ESRRG, swissprot: ERR3_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Cysteinyl leukotriene receptor 1 (Organism: Cavia porcellus, class: GPCR, accessions: Q2NNR5, gene: CYSLTR1, swissprot: CLTR1_CAVPO) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) UDP-glucose 4-epimerase (Organism: Homo sapiens, class: Enzyme, accessions: Q14376, gene: GALE, swissprot: GALE_HUMAN) Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) | antineoplastic agent (Code: CHEBI:35610) xenoestrogen (Code: CHEBI:76988) Carcinogens (Code: D002273) Estrogens (Code: D004967) Estrogens, Non-Steroidal (Code: D004968) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Noxae (Code: D009676) | 1973-05-30 FDA | 1S9P 1TT6 1TZ8 3ERD 4ZN7 |
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| sulfamethizole | Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | A sulfathiazole antibacterial agent. | antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) | 1953-10-28 FDA | |
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| moclobemide | Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Amine oxidase [flavin-containing] A (Organism: Bos taurus, class: Enzyme, accessions: P21398, gene: MAOA, swissprot: AOFA_BOVIN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | A reversible inhibitor of monoamine oxidase type A (RIMA) that has antidepressive properties. | antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | 1990-01-01 YEAR INTRODUCED | |
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| dichlorophen | Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.) | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anticestodal Agents (Code: D000923) Antifungal Agents (Code: D000935) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Antiprotozoal Agents (Code: D000981) | |
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| propatylnitrate | None | |
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| endralazine | Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| sulfasomizole | None | |
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| sulfamethylthiazole | None | |
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| rizatriptan | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Sus scrofa, class: GPCR, accessions: P79400, gene: HTR1D, swissprot: 5HT1D_PIG) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) | a selective 5-hydroxytryptamine (5-HT1B/1D) receptor agonist, used in the treatment of migraine headache | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) vasoconstrictor agent (Code: CHEBI:50514) anti-inflammatory drug (Code: CHEBI:35472) serotonergic agonist (Code: CHEBI:35941) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 1998-06-29 FDA | |
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| orphenadrine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Centrally-mediated Muscle Relaxation (Code: N0000175730) antidyskinesia agent (Code: CHEBI:66956) H1-receptor antagonist (Code: CHEBI:37955) antiparkinson drug (Code: CHEBI:48407) parasympatholytic (Code: CHEBI:50370) muscle relaxant (Code: CHEBI:51371) muscarinic antagonist (Code: CHEBI:48876) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Cytochrome P-450 CYP2B6 Inhibitors (Code: D065686) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Muscarinic Antagonists (Code: D018727) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | 1957-05-10 FDA | |
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| tolbutamide | Solute carrier family 22 member 6 (Organism: Rattus norvegicus, class: Transporter, accessions: O35956, gene: Slc22a6, swissprot: S22A6_RAT) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) ATP-sensitive inward rectifier potassium channel 11 (Organism: Mus musculus, class: Unclassified, accessions: Q61743, gene: Kcnj11, swissprot: KCJ11_MOUSE) | A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290) | Sulfonylurea (Code: N0000175608) Sulfonylurea Compounds (Code: N0000008054) hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) | 1961-06-22 FDA | |
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| moxastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | |
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| pramiracetam | cognition activator | |
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| leflunomide | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63707, gene: Dhodh, swissprot: PYRD_RAT) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q02127, gene: DHODH, swissprot: PYRD_HUMAN) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Mus musculus, class: Enzyme, accessions: O35435, gene: Dhodh, swissprot: PYRD_MOUSE) | inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway; antagonizes growth-factor mediated smooth muscle cell proliferation in vitro; structure given in first source | Antirheumatic Agent (Code: N0000175713) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antineoplastic agent (Code: CHEBI:35610) antiparasitic agent (Code: CHEBI:35442) prodrug (Code: CHEBI:50266) immunosuppressive agent (Code: CHEBI:35705) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) | 1998-09-10 FDA | |
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| estrone | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Steryl-sulfatase (Organism: Homo sapiens, class: Enzyme, accessions: P08842, gene: STS, swissprot: STS_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Estradiol 17-beta-dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14061, gene: HSD17B1, swissprot: DHB1_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. | bone density conservation agent (Code: CHEBI:50646) antineoplastic agent (Code: CHEBI:35610) Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1979-02-21 FDA | 3HM1 5HS6 |
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| hexestrol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | A synthetic estrogen that has been used as a hormonal antineoplastic agent. | Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Estrogens (Code: D004967) Estrogens, Non-Steroidal (Code: D004968) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 3CV6 |
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| doxylamine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM. | histamine antagonist (Code: CHEBI:37956) cholinergic antagonist (Code: CHEBI:48873) sedative (Code: CHEBI:35717) H1-receptor antagonist (Code: CHEBI:37955) antitussive (Code: CHEBI:51177) antiemetic (Code: CHEBI:50919) anti-allergic agent (Code: CHEBI:50857) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Antihistamine (Code: N0000175750) Histamine Receptor Antagonists (Code: N0000000207) Peripheral Nervous System Agents (Code: D018373) | 1948-04-07 FDA | |
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| tolonium | Microtubule-associated protein tau (Organism: Homo sapiens, class: Structural, accessions: P10636, gene: MAPT, swissprot: TAU_HUMAN) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery. | fluorochrome (Code: CHEBI:51217) histological dye (Code: CHEBI:77178) diagnostic agent (Code: CHEBI:33295) Coagulants (Code: D003029) Coloring Agents (Code: D004396) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Heparin Antagonists (Code: D006494) | |
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| fenethazine | None | |
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| mecloqualone | analogue of methaqualone used for the treatment of insomnia | |
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| clofenamide | None | |
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| chloroprocaine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) | None | Ester Local Anesthetic (Code: N0000175683) Esters (Code: N0000166743) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) peripheral nervous system drug (Code: CHEBI:49110) central nervous system depressant (Code: CHEBI:35488) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1955-03-11 FDA | |
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| medazepam | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) | A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM. | Anti-Anxiety Agents (Code: D014151) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| pentrinitrol | coronary vasodilator agent; minor descriptor (75-85); on-line & Index Medicus search PROPYLENE GLYCOLS (75-85) | |
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| delmopinol | None | Cosmetics (Code: D003358) Mouthwashes (Code: D009067) Surface-Active Agents (Code: D013501) | |
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| acetaminosalol | None | |
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| carbubarb | None | |
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| ftivazide | None | |
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| metiazinic acid | phenothiazine which acts as an anti-inflammatory agent; minor descriptor (75-86); on line & INDEX MEDICUS search PHENOTHIAZINES (75-86) | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | |
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| carbutamide | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | A sulfonylurea antidiabetic agent with similar actions and uses to CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277) | Hypoglycemic Agents (Code: D007004) | |
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| desomorphine | Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) | an informal term for a cheap injectable illicit drug domestically prepared from codeine-containing medication in Russia | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| subathizone | None | |
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| nepinalone | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) | None | |
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| dextromethorphan | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Glutamate receptor ionotropic, NMDA 2C (Organism: Homo sapiens, class: Ion channel, accessions: Q14957, gene: GRIN2C, swissprot: NMDE3_HUMAN) | Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity. | Uncompetitive N-methyl-D-aspartate Receptor Antagonist (Code: N0000181821) Sigma-1 Agonist (Code: N0000182149) Uncompetitive NMDA Receptor Antagonists (Code: N0000181819) Sigma-1 Receptor Agonists (Code: N0000182147) antitussive (Code: CHEBI:51177) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Neurotransmitter Agents (Code: D018377) Respiratory System Agents (Code: D019141) | 1957-12-03 FDA | |
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| bupranolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) | An adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| zoledronic acid | Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Neutrophil collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P22894, gene: MMP8, swissprot: MMP8_HUMAN) Geranylgeranyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: O95749, gene: GGPS1, swissprot: GGPPS_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Geranylgeranyl pyrophosphate synthase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: Q12051, gene: BTS1, swissprot: GGPPS_YEAST) Farnesyl pyrophosphate synthase (Organism: Leishmania donovani, class: Enzyme, accessions: Q0GKD7, gene: None, swissprot: Q0GKD7_LEIDO) Matrix metalloproteinase-14 (Organism: Homo sapiens, class: Enzyme, accessions: P50281, gene: MMP14, swissprot: MMP14_HUMAN) Farnesyl diphosphate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P22939, gene: ispA, swissprot: ISPA_ECOLI) Farnesyl pyrophosphate synthase (Organism: Rattus norvegicus, class: Unclassified, accessions: P05369, gene: Fdps, swissprot: FPPS_RAT) | a potent inhibitor of bone resorption; structure given in first source | bone density conservation agent (Code: CHEBI:50646) Bone Density Conservation Agents (Code: D050071) | 2001-03-20 EMA 2001-08-20 FDA | 1ZW5 2E91 2F8C 2F8Z 2F9K 2Q58 3EZ3 3IBA 3LDW 3N45 3N46 4KFA 4KQ5 4P0V 4P0W |
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| muzolimine | A pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects. | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| zolimidine | was MH 1977-92 (see under PYRIDINES 1977-90); SOLIMIDINE was see ZOLIMIDINE 1977-92; use PYRIDINES to search ZOLIMIDINE 1977-92; compound with analgesic, antipyretic & anti-inflammatory action; used mainly in the treatment of gastrointestinal ulcers due to its considerable mucopoietic action | |
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| perisoxal | None | |
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| sotalol | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias. | Antiarrhythmic (Code: N0000175426) Cardiac Rhythm Alteration (Code: N0000008330) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) beta-adrenergic antagonist (Code: CHEBI:35530) anti-arrhythmia drug (Code: CHEBI:38070) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1992-10-30 FDA | |
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| estradiol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211, gene: Esr1, swissprot: ESR1_RAT) Estrogen receptor (Organism: Mus musculus, class: Transcription factor, accessions: P19785, gene: Esr1, swissprot: ESR1_MOUSE) Estrogen receptor beta (Organism: Rattus norvegicus, class: Transcription factor, accessions: Q62986, gene: Esr2, swissprot: ESR2_RAT) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Steryl-sulfatase (Organism: Homo sapiens, class: Enzyme, accessions: P08842, gene: STS, swissprot: STS_HUMAN) Steroid hormone receptor ERR2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O95718, gene: ESRRB, swissprot: ERR2_HUMAN) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211|Q62986, gene: Esr1|Esr2, swissprot: ESR1_RAT|ESR2_RAT) Steroid hormone receptor ERR1 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11474, gene: ESRRA, swissprot: ERR1_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Estrogen receptor beta (Organism: Mus musculus, class: Transcription factor, accessions: O08537, gene: Esr2, swissprot: ESR2_MOUSE) G-protein coupled estrogen receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q99527, gene: GPER1, swissprot: GPER1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. | Estradiol Congeners (Code: N0000011402) Estrogen (Code: N0000175825) Estrogen Receptor Agonists (Code: N0000000100) Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1975-07-23 FDA | 1A27 1A52 1AQU 1E6W 1ERE 1FDS 1FDT 1FDU 1FDW 1G50 1GWR 1IOL 1JGL 1JNN 1LHU 1PCG 1QKT 1QKU 2D06 2J7X 2OCF 2YJA 3OLL 3OLS 3UUD 4J24 4J26 4JVL 4PXM 5DX3 5DXB 5DXE 5DXG 5GS4 5GTR 5HYR 5TOA 6CBZ |
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| quinisocaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| nimustine | Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms. | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) | |
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| tolcapone | Krueppel-like factor 10 (Organism: Homo sapiens, class: Unclassified, accessions: Q13118, gene: KLF10, swissprot: KLF10_HUMAN) Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). The precise mechanism of action of tolcapone is unknown, but it is believed to be related to its ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa. It is believed that these sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to greater effects on the signs and symptoms of Parkinson's disease patients. | Catechol-O-Methyltransferase Inhibitor (Code: N0000175757) antiparkinson drug (Code: CHEBI:48407) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Catechol O-Methyltransferase Inhibitors (Code: D065098) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) | 1998-01-29 FDA | 3S68 4D7B 4PYL 5A6I |
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| oxaflozane | None | |
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| stepronin | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Expectorants (Code: D005100) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Respiratory System Agents (Code: D019141) | |
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| modafinil | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | metabolite of adrafinyl; armodafinil is the (R)-isomer | Central Nervous System Stimulation (Code: N0000175729) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic-like Agent (Code: N0000175769) central nervous system stimulant (Code: CHEBI:35337) eugeroic (Code: CHEBI:77567) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Cytochrome P-450 CYP3A Inducers (Code: D065701) Metabolic Side Effects of Drugs and Substances (Code: D065606) Wakefulness-Promoting Agents (Code: D064690) | 1998-12-24 FDA | |
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| tilidine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | An opioid analgesic used similarly to MORPHINE in the control of moderate to severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1097) | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) opioid analgesic (Code: CHEBI:35482) prodrug (Code: CHEBI:50266) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1970-01-01 YEAR INTRODUCED | |
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| homatropine | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | minor descriptor (75-86); was see under BELLADONNA 1963-68 search TROPANES 1969-74 & BELLADONNA 1966-68; on line & INDEX MEDICUS search TROPANES (75-86); RN given refers to endo-(+-)isomer | Cholinergic Muscarinic Agonist (Code: N0000175840) Cholinergic Muscarinic Agonists (Code: N0000000104) Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | None FDA | 1MX5 2DQZ |
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| carprofen | Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) | anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1 | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) photosensitizing agent (Code: CHEBI:47868) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Dermatologic Agents (Code: D003879) Peripheral Nervous System Agents (Code: D018373) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) Sensory System Agents (Code: D018689) | 1987-12-31 FDA | 4DO3 4MJR 5FXT |
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| chlormezanone | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Anti-Anxiety Agents (Code: D014151) antipsychotic agent (Code: CHEBI:35476) anxiolytic drug (Code: CHEBI:35474) muscle relaxant (Code: CHEBI:51371) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1960-05-20 FDA | |
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| tryparsamide | was MH 1963-92; use TRYPANOCIDAL AGENTS to search TRYPARSAMIDE 1966-92 | |
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| guaiacol carbonate | None | |
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| ensulizole | sunscreening agent | None FDA | |
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| tybamate | major descriptor (65-84); on-line search CARBAMATES (65-84); Index Medicus search TYBAMATE (65-84) | |
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| nandrolone | Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position. | Androgen (Code: N0000175824) Anabolic Agents (Code: D045930) Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 5KP4 |
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| ropivacaine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel protein type 8 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UQD0, gene: SCN8A, swissprot: SCN8A_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | amide local anesthetic with characteristics similar to bupivacaine; from Apothekernes Laboratorium, Oslo, Norway; RN given refers to (S)-isomer; RN for parent cpd without isomeric designation not available 2/89 | Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1996-09-24 FDA | |
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| chlorphenamine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Chloroquine resistance transporter (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q9N623, gene: CRT, swissprot: CRT_PLAFA) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Lethal(3)malignant brain tumor-like protein 3 (Organism: Homo sapiens, class: Unclassified, accessions: Q96JM7, gene: L3MBTL3, swissprot: LMBL3_HUMAN) Lethal(3)malignant brain tumor-like protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9Y468, gene: L3MBTL1, swissprot: LMBL1_HUMAN) MBT domain-containing protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q05BQ5, gene: MBTD1, swissprot: MBTD1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) Anti-Allergic Agents (Code: D018926) serotonin uptake inhibitor (Code: CHEBI:50949) antidepressant (Code: CHEBI:35469) H1-receptor antagonist (Code: CHEBI:37955) histamine antagonist (Code: CHEBI:37956) antipruritic drug (Code: CHEBI:59683) anti-allergic agent (Code: CHEBI:50857) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1950-08-15 FDA | |
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| iobenguane (123I) | None | Radioactive Diagnostic Agent (Code: N0000177914) Radiopharmaceutical Activity (Code: N0000000205) | 2008-09-19 FDA | |
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| acetarsol | None | Anti-Infective Agents (Code: D000890) | |
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| nifuroxazide | Signal transducer and activator of transcription 3 (Organism: Homo sapiens, class: Transcription factor, accessions: P40763, gene: STAT3, swissprot: STAT3_HUMAN) | None | Anti-Infective Agents (Code: D000890) | |
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| furalazine | None | |
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| meturedepa | None | |
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| tipepidine | None | |
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| meticrane | None | |
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| physostigmine | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Acetylcholinesterase (Organism: Gallus gallus, class: Unclassified, accessions: P36196, gene: ACHE, swissprot: ACES_CHICK) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Cholinesterase (Organism: Mus musculus, class: Enzyme, accessions: Q03311, gene: Bche, swissprot: CHLE_MOUSE) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Muscarinic acetylcholine receptor M1 (Organism: Mus musculus, class: GPCR, accessions: P12657, gene: Chrm1, swissprot: ACM1_MOUSE) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | antidote to curare poisoning (Code: CHEBI:74530) miotic (Code: CHEBI:51068) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Miotics (Code: D008916) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1875-01-01 YEAR INTRODUCED | |
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| propipocaine | None | |
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| cyclobenzaprine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) | structurally related to tricyclic antidepressants relieves skeletal muscle spasm of local origin without interfering with muscle function, it is ineffective in muscle spasm due to central nervous system disease | Centrally-mediated Muscle Relaxation (Code: N0000175730) muscle relaxant (Code: CHEBI:51371) tranquilizing drug (Code: CHEBI:35473) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1977-08-26 FDA | |
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| propiram | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | None | 1980-01-01 YEAR INTRODUCED | |
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| flutamide | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | Flutamide is an acetanilid, nonsteroidal, orally active antiandrogen. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. | Androgen Receptor Antagonists (Code: N0000000243) Androgen Receptor Inhibitor (Code: N0000175560) Androgen Antagonists (Code: D000726) antineoplastic agent (Code: CHEBI:35610) androgen antagonist (Code: CHEBI:35497) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1989-01-27 FDA | |
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| oxagrelate | Phosphodiesterase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P54750|Q01064|Q14123, gene: PDE1A|PDE1B|PDE1C, swissprot: PDE1A_HUMAN|PDE1B_HUMAN|PDE1C_HUMAN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) | None | Enzyme Inhibitors (Code: D004791) Phosphodiesterase Inhibitors (Code: D010726) | |
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| sulfabenzamide | None | 1945-09-12 FDA | 3RCF |
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| cyclandelate | A direct-acting SMOOTH MUSCLE relaxant used to dilate BLOOD VESSELS. | vasodilator agent (Code: CHEBI:35620) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| entecavir | Protein P (Organism: Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988), class: Polyprotein, accessions: P17394, gene: P, swissprot: DPOL_HBVB1) Protein P (Organism: Hepatitis B virus, class: Polyprotein, accessions: Q9IF40, gene: P, swissprot: Q9IF40_HBV) | Entecavir, a guanosine nucleoside analogue with activity against HBV reverse transcriptase, is efficiently phosphorylated to the active triphosphate form, which has an intracellular half-life of 15 hours. By competing with the natural substrate deoxyguanosine triphosphate, entecavir triphosphate functionally inhibits all three activities of the HBV reverse transcriptase: (1) base priming, (2) reverse transcription of the negative strand from the pregenomic messenger RNA, and (3) synthesis of the positive strand of HBV DNA. Entecavir triphosphate is a weak inhibitor of cellular DNA polymerases alpha, beta, and delta and mitochondrial DNA polymerase gamma with Ki values ranging from 18 to > 160 microM. | antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 2005-03-29 FDA | |
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| tetraethylphthalamide | None | |
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| molindone | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283) | Typical Antipsychotic (Code: N0000180182) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1974-01-18 FDA | |
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| mebhydrolin | 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) | see also record for mebhydroline, RN: 524-81-2 | 1954-01-01 YEAR INTRODUCED | |
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| bolandiol dipropionate | anabolic steroid with androgenic, estrogenic, and progestational activities | |
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| etidocaine | Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) | A local anesthetic with rapid onset and long action, similar to BUPIVACAINE. | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1976-08-30 FDA | |
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| chlorpropamide | Solute carrier family 22 member 6 (Organism: Rattus norvegicus, class: Transporter, accessions: O35956, gene: Slc22a6, swissprot: S22A6_RAT) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277) | Sulfonylurea (Code: N0000175608) Sulfonylurea Compounds (Code: N0000008054) hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) | 1958-10-28 FDA | |
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| neridronic acid | Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) | used for therapy of Paget's disease of bone & malignant hypercalcaemia | 5ER8 |
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| clenbuterol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) bronchodilator agent (Code: CHEBI:35523) beta-adrenergic agonist (Code: CHEBI:35522) sympathomimetic agent (Code: CHEBI:35524) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) | |
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| azathioprine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) RNA (Organism: None, class: RNA, accessions: None, gene: None, swissprot: None) Thiopurine S-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P51580, gene: TPMT, swissprot: TPMT_HUMAN) Ras-related C3 botulinum toxin substrate 1 (Organism: Homo sapiens, class: Unclassified, accessions: P63000, gene: RAC1, swissprot: RAC1_HUMAN) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) | An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed) | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Analog (Code: N0000175459) Purine Antimetabolite (Code: N0000175712) Purines (Code: N0000008065) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Antirheumatic Agents (Code: D018501) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) | 1968-03-20 FDA | |
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| folescutol | capillary therapeutic agent; vascular protector; structure | |
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| elliptinium | Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) | synthetic ellipticine deriv; RN given refers to parent cpd; structure given in first source | Antineoplastic Agents (Code: D000970) Indicators and Reagents (Code: D007202) Intercalating Agents (Code: D007364) | |
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| venlafaxine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) | A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. | Norepinephrine Uptake Inhibitors (Code: N0000000102) Serotonin and Norepinephrine Reuptake Inhibitor (Code: N0000175749) Serotonin Uptake Inhibitors (Code: N0000000109) serotonin uptake inhibitor (Code: CHEBI:50949) adrenergic uptake inhibitor (Code: CHEBI:35640) dopamine uptake inhibitor (Code: CHEBI:51039) analgesic (Code: CHEBI:35480) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin and Noradrenaline Reuptake Inhibitors (Code: D000068760) | 1993-12-28 FDA | |
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| maprotiline | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) | A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1980-12-01 FDA | |
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| amitriptyline | 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) antidepressant (Code: CHEBI:35469) adrenergic uptake inhibitor (Code: CHEBI:35640) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) | 1961-04-07 FDA | 3APV 5HA9 |
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| perhexiline | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Carnitine palmitoyltransferase 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P18886, gene: Cpt2, swissprot: CPT2_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Carnitine palmitoyltransferase 1A (Organism: Rattus norvegicus, class: Unclassified, accessions: P32198, gene: Cpt1a, swissprot: CPT1A_RAT) Carnitine O-palmitoyltransferase 2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P23786, gene: CPT2, swissprot: CPT2_HUMAN) Carnitine O-palmitoyltransferase 1, liver isoform (Organism: Homo sapiens, class: Enzyme, accessions: P50416, gene: CPT1A, swissprot: CPT1A_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1I (Organism: Homo sapiens, class: Ion channel, accessions: Q9P0X4, gene: CACNA1I, swissprot: CAC1I_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) | 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis. | cardiovascular drug (Code: CHEBI:35554) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) | |
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| treosulfan | immunosuppressant; RN given refers to (S-(R*,R*))-isomer | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| lomifylline | None | |
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| pentoxifylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. | Blood Viscosity Reducer (Code: N0000175895) Hematologic Activity Alteration (Code: N0000009065) Antioxidants (Code: D000975) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Free Radical Scavengers (Code: D016166) Hematologic Agents (Code: D006401) Phosphodiesterase Inhibitors (Code: D010726) Platelet Aggregation Inhibitors (Code: D010975) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) Vasodilator Agents (Code: D014665) | 1984-08-30 FDA | 2A3C 3ARR 3ARU 3TVX |
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| sulfisomidine | A sulfanilamide antibacterial agent. | antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) | |
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| sulfadimidine | Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) Lactoylglutathione lyase (Organism: Homo sapiens, class: Enzyme, accessions: Q04760, gene: GLO1, swissprot: LGUL_HUMAN) | A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides. | antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) | 1949-08-16 FDA | |
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| tolycaine | None | |
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| proquazone | Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | nonsteroid anti-inflammatory agent | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| demexiptiline | None | |
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| sodium gualenate | None | 1986-01-01 YEAR INTRODUCED | |
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| trichloroethylene | A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment. | inhalation anaesthetic (Code: CHEBI:38870) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Solvents (Code: D012997) | |
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| egualen | a stable azulene derivative, antiulcer agent | anti-ulcer drug (Code: CHEBI:49201) | None PMDA | |
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| dimethocaine | None | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| triprolidine | Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness. | Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1983-05-17 FDA | |
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| gamolenic acid | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Tissue factor (Organism: Homo sapiens, class: Membrane receptor, accessions: P13726, gene: F3, swissprot: TF_HUMAN) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P31213, gene: SRD5A2, swissprot: S5A2_HUMAN) | An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed) | |
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| clidanac | minor descriptor (75-89); on-line search INDENES & CYCLOHEXANES (71-74) & INDANS (75-89); INDEX MEDICUS search INDENES (71-89) | |
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| acecarbromal | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| cidofovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) | potent, selective inhibitor of human cytomegalovirus replication | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1996-06-26 FDA | 5KM8 |
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| oxamniquine | An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121) | Antihelminthic (Code: N0000175481) Anthelmintics (Code: D000871) schistosomicide drug (Code: CHEBI:38941) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Schistosomicides (Code: D012556) | 1980-07-23 FDA | 4MUB 5BYJ 5BYK 5TIW 5TIX 5TIY |
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| ramosetron | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | None | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1996-07-10 PMDA | |
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| sulfalene | Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Renal Agents (Code: D012076) | |
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| etamiphylline | None | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| moxisylyte | An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312) | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Miotics (Code: D008916) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) Vasodilator Agents (Code: D014665) | |
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| letosteine | None | mucolytic (Code: CHEBI:77034) Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | |
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| doxepin | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) | A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors. | Tricyclic Antidepressant (Code: N0000175752) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Sleep Aids, Pharmaceutical (Code: D000068776) | 1969-09-23 FDA | 3RZE |
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| bendazac | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antimetabolites (Code: D000963) Antirheumatic Agents (Code: D018501) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| fenpiprane | None | |
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| sibutramine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Potassium voltage-gated channel subfamily D member 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UK17, gene: KCND3, swissprot: KCND3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Potassium voltage-gated channel subfamily D member 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62897, gene: Kcnd3, swissprot: KCND3_RAT) | serotonin and norepinephrine transporter inhibitor; Meridia is tradename for sibutramine hydrochloride | Appetite Suppression (Code: N0000175372) Dopamine Uptake Inhibitors (Code: N0000000114) Norepinephrine Uptake Inhibitors (Code: N0000000102) Norepinephrine, Serotonin, and Dopamine Reuptake Inhibitor Anorectic (Code: N0000175424) Serotonin Uptake Inhibitors (Code: N0000000109) serotonin uptake inhibitor (Code: CHEBI:50949) Anti-Obesity Agents (Code: D019440) Antidepressive Agents (Code: D000928) Appetite Depressants (Code: D001067) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | 1997-11-22 FDA | |
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| levosimendan | ATP-sensitive inward rectifier potassium channel 8 (Organism: Homo sapiens, class: Ion channel, accessions: Q15842, gene: KCNJ8, swissprot: KCNJ8_HUMAN) ATP-sensitive inward rectifier potassium channel 11 (Organism: Homo sapiens, class: Ion channel, accessions: Q14654, gene: KCNJ11, swissprot: KCJ11_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) Troponin C, slow skeletal and cardiac muscles (Organism: Homo sapiens, class: Cytosolic other, accessions: P63316, gene: TNNC1, swissprot: TNNC1_HUMAN) | neuroprotectant; a troponin modifier, a phosphodiesterase III inhibitor, and an inhibitor of voltage-sensitive Ca(2+) current; structure given in second source | cardiotonic drug (Code: CHEBI:38147) vasodilator agent (Code: CHEBI:35620) anti-arrhythmia drug (Code: CHEBI:38070) | |
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| flumecinol | liver microsomal drug metabolizing enzyme inducer | |
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| sulfamonomethoxine | Long acting sulfonamide antibacterial agent. | Anti-Infective Agents (Code: D000890) | |
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| sulfamethoxypyridazine | A sulfanilamide antibacterial agent. | antiinfective agent (Code: CHEBI:35441) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1960-01-01 YEAR INTRODUCED | |
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| sulfameter | Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections. | antiinfective agent (Code: CHEBI:35441) renal agent (Code: CHEBI:35846) leprostatic drug (Code: CHEBI:35816) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Leprostatic Agents (Code: D007917) Renal Agents (Code: D012076) | 1966-07-01 FDA | |
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| phenprocoumon | Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Vitamin K epoxide reductase complex subunit 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BQB6, gene: VKORC1, swissprot: VKOR1_HUMAN) | Coumarin derivative that acts as a long acting oral anticoagulant. | Vitamin K Antagonist (Code: N0000175476) Vitamin K Inhibitors (Code: N0000175964) anticoagulant (Code: CHEBI:50249) Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | 1957-12-30 FDA | |
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| ipriflavone | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | None | bone density conservation agent (Code: CHEBI:50646) | |
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| hydroxystilbamidine | Trypsin (Organism: Sus scrofa, class: Unclassified, accessions: P00761, gene: None, swissprot: TRYP_PIG) | minor descriptor (63-86); on-line & INDEX MEDICUS search STILBAMIDINES (66-86); RN given refers to parent cpd | 1953-12-22 FDA | |
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| mefexamide | proposed psychotherapeutic agent with stimulatory action; minor descriptor (76-83); on-line & Index Medicus search GLYCOLATES (76-83) | |
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| hydroxytetracaine | None | |
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| tromantadine | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | |
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| imipramine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Potassium voltage-gated channel subfamily H member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O95259, gene: KCNH1, swissprot: KCNH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Muscarinic acetylcholine receptor M5 (Organism: Rattus norvegicus, class: GPCR, accessions: P08911, gene: Chrm5, swissprot: ACM5_RAT) Sodium-dependent dopamine transporter (Organism: Mus musculus, class: Transporter, accessions: Q61327, gene: Slc6a3, swissprot: SC6A3_MOUSE) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) 5-hydroxytryptamine receptor 2C (Organism: Mus musculus, class: GPCR, accessions: P34968, gene: Htr2c, swissprot: 5HT2C_MOUSE) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) D(2) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: P61168, gene: Drd2, swissprot: DRD2_MOUSE) Sodium-dependent serotonin transporter (Organism: Mus musculus, class: Transporter, accessions: Q60857, gene: Slc6a4, swissprot: SC6A4_MOUSE) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) G protein-activated inward rectifier potassium channel 4 (Organism: Mus musculus, class: Unclassified, accessions: P48545, gene: Kcnj5, swissprot: KCNJ5_MOUSE) | The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) adrenergic uptake inhibitor (Code: CHEBI:35640) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1959-04-16 FDA | 2Q72 |
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| histapyrrodine | None | |
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| bamipine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | |
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| linoleic acid | Free fatty acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: O14842, gene: FFAR1, swissprot: FFAR1_HUMAN) Potassium voltage-gated channel subfamily B member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q14721, gene: KCNB1, swissprot: KCNB1_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Fatty acid-binding protein, heart (Organism: Homo sapiens, class: Cytosolic other, accessions: P05413, gene: FABP3, swissprot: FABPH_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Seed linoleate 13S-lipoxygenase-1 (Organism: Glycine max, class: Enzyme, accessions: P08170, gene: LOX1.1, swissprot: LOX1_SOYBN) Tissue factor (Organism: Homo sapiens, class: Membrane receptor, accessions: P13726, gene: F3, swissprot: TF_HUMAN) Fatty acid-binding protein, adipocyte (Organism: Homo sapiens, class: Cytosolic other, accessions: P15090, gene: FABP4, swissprot: FABP4_HUMAN) Free fatty acid receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q5NUL3, gene: FFAR4, swissprot: FFAR4_HUMAN) | A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed) | 1IGZ 2EVL 2Q9S 4DQ4 4IA6 4LKT 4NYQ 5BVS |
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| flufenamic acid | Taste receptor type 2 member 14 (Organism: Homo sapiens, class: GPCR, accessions: Q9NYV8, gene: TAS2R14, swissprot: T2R14_HUMAN) Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) Transient receptor potential cation channel subfamily M member 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8TD43, gene: TRPM4, swissprot: TRPM4_HUMAN) Transient receptor potential cation channel subfamily M member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O94759, gene: TRPM2, swissprot: TRPM2_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Transient receptor potential cation channel subfamily M member 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NZQ8, gene: TRPM5, swissprot: TRPM5_HUMAN) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Aldo-keto reductase family 1 member C1 (Organism: Homo sapiens, class: Enzyme, accessions: Q04828, gene: AKR1C1, swissprot: AK1C1_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Aldo-keto reductase family 1 member B10 (Organism: Homo sapiens, class: Enzyme, accessions: O60218, gene: AKR1B10, swissprot: AK1BA_HUMAN) Potassium channel subfamily T member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q6UVM3, gene: KCNT2, swissprot: KCNT2_HUMAN) Transient receptor potential cation channel subfamily M member 4 (Organism: Mus musculus, class: Unclassified, accessions: Q7TN37, gene: Trpm4, swissprot: TRPM4_MOUSE) | An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16) | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) | 1963-01-01 YEAR INTRODUCED | 1BM7 1S2C 2PIX 3OZL 4I5X 5DQ8 5IKV |
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| bibenzonium | None | |
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| nitrazepam | GABA-A receptor; anion channel (Organism: Bos taurus, class: Ion channel, accessions: P08219|P08220|P10063|P10064|P20237|P22300, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRB1|GABRG2, swissprot: GBRA1_BOVIN|GBRA2_BOVIN|GBRA3_BOVIN|GBRA4_BOVIN|GBRB1_BOVIN|GBRG2_BOVIN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A benzodiazepine derivative used as an anticonvulsant and hypnotic. | Anti-Anxiety Agents (Code: D014151) anticonvulsant (Code: CHEBI:35623) antispasmodic drug (Code: CHEBI:53784) GABA modulator (Code: CHEBI:50268) sedative (Code: CHEBI:35717) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| trimetozine | None | |
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| indoprofen | Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) | A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21) | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| ciclosidomine | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| albendazole sulfoxide | Tubulin alpha chain (Organism: Haemonchus contortus, class: Structural, accessions: P50719, gene: None, swissprot: TBA_HAECO) | None | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anticestodal Agents (Code: D000923) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) | 1982-01-01 YEAR INTRODUCED | |
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| piberaline | None | |
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| phentolamine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) alpha-adrenergic antagonist (Code: CHEBI:37890) vasodilator agent (Code: CHEBI:35620) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1952-01-30 FDA | |
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| diphenylpyraline | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) | an antihistamine used to treat allergic rhinitis, hay fever, and allergic skin disorders, diphenylpyraline blocks the action of endogenous histamine at the histamine H1 receptor | H1-receptor antagonist (Code: CHEBI:37955) cholinergic antagonist (Code: CHEBI:48873) | None FDA | |
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| xanomeline | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Muscarinic acetylcholine receptor M1 (Organism: Mus musculus, class: GPCR, accessions: P12657, gene: Chrm1, swissprot: ACM1_MOUSE) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | a cholinergic agonist; used in the treatment of Alzheimer's disease; structure given in first source | muscarinic agonist (Code: CHEBI:38325) serotonergic agonist (Code: CHEBI:35941) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) | |
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| terodiline | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Terodiline relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity | Autonomic Agents (Code: D001337) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| alverine | None | antispasmodic drug (Code: CHEBI:53784) Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| niflumic acid | Chloride channel protein ClC-Ka (Organism: Homo sapiens, class: Ion channel, accessions: P51800, gene: CLCNKA, swissprot: CLCKA_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) Chloride channel protein ClC-Kb (Organism: Homo sapiens, class: Ion channel, accessions: P51801, gene: CLCNKB, swissprot: CLCKB_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) Potassium channel subfamily T member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q6UVM3, gene: KCNT2, swissprot: KCNT2_HUMAN) | An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1TD7 2WM3 |
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| artemisinin | Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) | antimalarial from Chinese medicinal herb Artemisia annua | antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) | |
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| vedaprofen | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) anti-ulcer drug (Code: CHEBI:49201) non-narcotic analgesic (Code: CHEBI:35481) | 4MJP |
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| octatropine methylbromide | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | minor descriptor (65-86); on line & INDEX MEDICUS search TROPANES (69-86); RN given refers to endo-isomer | anti-ulcer drug (Code: CHEBI:49201) muscarinic antagonist (Code: CHEBI:48876) parasympatholytic (Code: CHEBI:50370) | 1962-11-23 FDA | |
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| cadralazine | Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1988-01-01 YEAR INTRODUCED | |
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| oleic acid | Free fatty acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: O14842, gene: FFAR1, swissprot: FFAR1_HUMAN) Fatty-acid amide hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O00519, gene: FAAH, swissprot: FAAH1_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Fatty acid-binding protein, epidermal (Organism: Homo sapiens, class: Cytosolic other, accessions: Q01469, gene: FABP5, swissprot: FABP5_HUMAN) Fatty acid-binding protein, liver (Organism: Homo sapiens, class: Unclassified, accessions: P07148, gene: FABP1, swissprot: FABPL_HUMAN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Seed linoleate 13S-lipoxygenase-1 (Organism: Glycine max, class: Enzyme, accessions: P08170, gene: LOX1.1, swissprot: LOX1_SOYBN) Tissue factor (Organism: Homo sapiens, class: Membrane receptor, accessions: P13726, gene: F3, swissprot: TF_HUMAN) Fatty acid-binding protein, adipocyte (Organism: Homo sapiens, class: Cytosolic other, accessions: P15090, gene: FABP4, swissprot: FABP4_HUMAN) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) Free fatty acid receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q5NUL3, gene: FFAR4, swissprot: FFAR4_HUMAN) Telomerase reverse transcriptase (Organism: Homo sapiens, class: Enzyme, accessions: O14746, gene: TERT, swissprot: TERT_HUMAN) | An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed) | solvent (Code: CHEBI:46787) | None FDA | |
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| tribromoethanol | major descriptor (66-90); on-line search ETHANOL (66-90); INDEX MEDICUS search TRIBROMOETHANOL (66-90) | Anesthetics (Code: D000777) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | |
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| risedronic acid | Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Farnesyl diphosphate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q197X6, gene: FPPS, swissprot: Q197X6_TOXGO) Farnesyl diphosphate synthase (Organism: Trypanosoma cruzi, class: Unclassified, accessions: Q8WS26, gene: None, swissprot: Q8WS26_TRYCR) Farnesyl pyrophosphate synthase (Organism: Leishmania donovani, class: Enzyme, accessions: Q0GKD7, gene: None, swissprot: Q0GKD7_LEIDO) | An aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS. | Bisphosphonate (Code: N0000175579) Diphosphonates (Code: N0000007707) Bone Density Conservation Agents (Code: D050071) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | 1998-03-27 FDA | 1RQJ 1YHL 1YQ7 1YV5 2O1O 2QIS 4KPD 4KQS 4N9U 4NG6 4NKE 4NUA 4Q23 4RXD 5CG5 5CG6 |
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| papaveroline | None | |
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| afloqualone | None | Central Nervous System Agents (Code: D002491) Dermatologic Agents (Code: D003879) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) | |
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| levallorphan | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) | An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683) | Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| trolnitrate | synonym Angitrit refers to phosphate; structure #412; RN given refers to parent cpd | |
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| tropisetron | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Cavia porcellus, class: Ion channel, accessions: O70212, gene: HTR3A, swissprot: 5HT3A_CAVPO) Serotonin 3 receptor (5HT3) (Organism: Mus musculus, class: Ion channel, accessions: P23979|Q9JHJ5, gene: Htr3a|Htr3b, swissprot: 5HT3A_MOUSE|5HT3B_MOUSE) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P32297, gene: CHRNA3, swissprot: ACHA3_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Mus musculus, class: Ion channel, accessions: P49582, gene: Chrna7, swissprot: ACHA7_MOUSE) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 3B (Organism: Homo sapiens, class: Ion channel, accessions: O95264, gene: HTR3B, swissprot: 5HT3B_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: Q62758, gene: Htr4, swissprot: 5HT4R_RAT) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Glycine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P23416, gene: GLRA2, swissprot: GLRA2_HUMAN) Glycine receptor subunit beta (Organism: Homo sapiens, class: Ion channel, accessions: P48167, gene: GLRB, swissprot: GLRB_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Mus musculus, class: Unclassified, accessions: P97288, gene: Htr4, swissprot: 5HT4R_MOUSE) | None | serotonergic antagonist (Code: CHEBI:48279) antiemetic (Code: CHEBI:50919) nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) trypanocidal drug (Code: CHEBI:36335) immunomodulator (Code: CHEBI:50846) neuroprotective agent (Code: CHEBI:63726) anti-inflammatory agent (Code: CHEBI:67079) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1992-01-01 YEAR INTRODUCED | 2WNC |
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| tropicamide | Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) | One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic. | Anticholinergic (Code: N0000175574) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1960-02-23 FDA | |
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| taurolidine | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antineoplastic Agents (Code: D000970) | |
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| sulfaethidole | minor descriptor (66-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd | |
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| articaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE. | Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2000-04-03 FDA | |
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| etozolin | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| methylthioninium chloride | iron (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Glutathione reductase (Organism: Plasmodium falciparum (isolate 3D7), class: Enzyme, accessions: O15770, gene: GR3, swissprot: GSHR_PLAF7) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) Microtubule-associated protein tau (Organism: Homo sapiens, class: Structural, accessions: P10636, gene: MAPT, swissprot: TAU_HUMAN) Thioredoxin reductase 1, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: Q16881, gene: TXNRD1, swissprot: TRXR1_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Amyloid beta A4 protein (Organism: Homo sapiens, class: Unclassified, accessions: P05067, gene: APP, swissprot: A4_HUMAN) | A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN. | acid-base indicator (Code: CHEBI:50407) fluorochrome (Code: CHEBI:51217) antidepressant (Code: CHEBI:35469) cardioprotective agent (Code: CHEBI:77307) histological dye (Code: CHEBI:77178) neuroprotective agent (Code: CHEBI:63726) physical tracer (Code: CHEBI:35208) antimalarial (Code: CHEBI:38068) Enzyme Inhibitors (Code: D004791) | None FDA | 2YVE 3ZYX 4XYP 5ACM 5DLP 5E4T |
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| promethazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) Chloroquine resistance transporter (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q9N623, gene: CRT, swissprot: CRT_PLAFA) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Anti-Allergic Agents (Code: D018926) sedative (Code: CHEBI:35717) antiemetic (Code: CHEBI:50919) local anaesthetic (Code: CHEBI:36333) antipruritic drug (Code: CHEBI:59683) anti-allergic agent (Code: CHEBI:50857) H1-receptor antagonist (Code: CHEBI:37955) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1951-03-29 FDA | |
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| promazine | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. | dopaminergic antagonist (Code: CHEBI:48561) H1-receptor antagonist (Code: CHEBI:37955) muscarinic antagonist (Code: CHEBI:48876) serotonergic antagonist (Code: CHEBI:48279) phenothiazine antipsychotic drug (Code: CHEBI:37930) antiemetic (Code: CHEBI:50919) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1956-04-13 FDA | 4MA7 |
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| lynestrenol | A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | |
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| iprindole | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257) | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| sulfachlorpyridazine | A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. | antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | |
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| disulfamide | None | |
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| mazindol | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) | Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 1973-06-14 FDA | 4MME 4MMF |
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| diazepam | Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P23576, gene: Gabra2, swissprot: GBRA2_RAT) GABA-A receptor; alpha-1/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P62813|P63138, gene: Gabra1|Gabrb2|Gabrg2, swissprot: GBRA1_RAT|GBRB2_RAT|GBRG2_RAT) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P62813, gene: Gabra1, swissprot: GBRA1_RAT) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Gamma-aminobutyric acid receptor subunit alpha-5 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19969, gene: Gabra5, swissprot: GBRA5_RAT) GABA-A receptor; anion channel (Organism: Bos taurus, class: Ion channel, accessions: P08219|P08220|P10063|P10064|P20237|P22300, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRB1|GABRG2, swissprot: GBRA1_BOVIN|GBRA2_BOVIN|GBRA3_BOVIN|GBRA4_BOVIN|GBRB1_BOVIN|GBRG2_BOVIN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P20236|P63138, gene: Gabra3|Gabrb2|Gabrg2, swissprot: GBRA3_RAT|GBRB2_RAT|GBRG2_RAT) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) GABA A receptor alpha-5/beta-3/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P19969|P63079, gene: Gabra5|Gabrb3|Gabrg2, swissprot: GBRA5_RAT|GBRB3_RAT|GBRG2_RAT) GABA A receptor alpha-6/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P30191|P63138, gene: Gabra6|Gabrb2|Gabrg2, swissprot: GBRA6_RAT|GBRB2_RAT|GBRG2_RAT) Translocator protein (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P16257, gene: Tspo, swissprot: TSPO_RAT) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor; anion channel (Organism: Mus musculus, class: Ion channel, accessions: A2AMW3|P16305|P22723|P22933|P26048|P26049|P27681|P50571|P62812|P63080|Q8BHJ7|Q8QZW7|Q9D6F4|Q9JLF1|Q9R0Y8, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: A2AMW3_MOUSE|GBRA1_MOUSE|GBRA2_MOUSE|GBRA3_MOUSE|GBRA4_MOUSE|GBRA5_MOUSE|GBRA6_MOUSE|GBRB1_MOUSE|GBRB3_MOUSE|GBRD_MOUSE|GBRG1_MOUSE|GBRG2_MOUSE|GBRG3_MOUSE|GBRP_MOUSE|GBRT_MOUSE) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P23576|P63138, gene: Gabra2|Gabrb2|Gabrg2, swissprot: GBRA2_RAT|GBRB2_RAT|GBRG2_RAT) GABA A receptor alpha-3/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903|P47870|Q99928, gene: GABRA3|GABRB2|GABRG3, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P47870|Q99928, gene: GABRA1|GABRB2|GABRG3, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P31644|P47870|Q99928, gene: GABRA5|GABRB2|GABRG3, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-3/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472|P31644|Q99928, gene: GABRA5|GABRB3|GABRG3, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-5 (Organism: Homo sapiens, class: Ion channel, accessions: P31644, gene: GABRA5, swissprot: GBRA5_HUMAN) Thyrotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q01717, gene: Trhr, swissprot: TRFR_RAT) | A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Adjuvants, Anesthesia (Code: D000759) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Anti-Anxiety Agents (Code: D014151) anxiolytic drug (Code: CHEBI:35474) anticonvulsant (Code: CHEBI:35623) sedative (Code: CHEBI:35717) Anticonvulsants (Code: D000927) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Gastrointestinal Agents (Code: D005765) Hypnotics and Sedatives (Code: D006993) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1963-11-15 FDA | 2BXF |
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| probenecid | Solute carrier family 22 member 8 (Organism: Homo sapiens, class: Transporter, accessions: Q8TCC7, gene: SLC22A8, swissprot: S22A8_HUMAN) Solute carrier family 22 member 11 (Organism: Homo sapiens, class: Transporter, accessions: Q9NSA0, gene: SLC22A11, swissprot: S22AB_HUMAN) Solute carrier family 22 member 12 (Organism: Homo sapiens, class: Transporter, accessions: Q96S37, gene: SLC22A12, swissprot: S22AC_HUMAN) UDP-glucuronosyltransferase 1-7 (Organism: Homo sapiens, class: Enzyme, accessions: Q9HAW7, gene: UGT1A7, swissprot: UD17_HUMAN) Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) Solute carrier family 22 member 6 (Organism: Mus musculus, class: Transporter, accessions: Q8VC69, gene: Slc22a6, swissprot: S22A6_MOUSE) Solute carrier family 22 member 6 (Organism: Homo sapiens, class: Transporter, accessions: Q4U2R8, gene: SLC22A6, swissprot: S22A6_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Transient receptor potential cation channel subfamily V member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q9WUD2, gene: Trpv2, swissprot: TRPV2_RAT) | The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. | Adjuvants, Pharmaceutic (Code: D000277) uricosuric drug (Code: CHEBI:35841) Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Pharmaceutic Aids (Code: D010592) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) | 1951-04-26 FDA | |
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| bromebric acid | major descriptor (74-86); on line search ACRYLATES (74-86); INDEX MEDICUS search BROMEBRIC ACID (74-86); RN given refers to parent cpd | |
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| nifuratel | Local antiprotozoal and antifungal agent that may also be given orally. | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antitrichomonal Agents (Code: D000994) | |
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| letrozole | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN) | Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. Used in treatment of hormonally responsive breast cancer (i.e., estrogen and/or progesterone receptor positive or receptor unknown) | Aromatase Inhibitor (Code: N0000175563) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 1997-07-25 FDA | |
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| faropenem | None | 3BFF 4HKY |
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| morphine | Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Delta-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P32300, gene: Oprd1, swissprot: OPRD_MOUSE) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) Kappa-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P34975, gene: Oprk1, swissprot: OPRK_RAT) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Bos taurus, class: GPCR, accessions: P79350, gene: OPRM1, swissprot: OPRM_BOVIN) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) Nociceptin receptor (Organism: Cavia porcellus, class: GPCR, accessions: P47748, gene: OPRL1, swissprot: OPRX_CAVPO) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Opioid receptor (Organism: Mus musculus, class: GPCR, accessions: O55242|P32300|P33534|P42866, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_MOUSE|OPRK_MOUSE|OPRM_MOUSE|SGMR1_MOUSE) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu opioid receptor-like OR2 (Organism: Danio rerio, class: Unclassified, accessions: Q98UH1, gene: oprm1, swissprot: Q98UH1_DANRE) | The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) mu-opioid receptor agonist (Code: CHEBI:55322) vasodilator agent (Code: CHEBI:35620) anaesthetic (Code: CHEBI:38867) opioid analgesic (Code: CHEBI:35482) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | 1Q0Y |
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| hydromorphone | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) | An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1984-01-11 FDA | |
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| medrylamine | None | |
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| mepyramine | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies. | Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Sleep Aids, Pharmaceutical (Code: D000068776) | 1973-08-07 FDA | |
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| prothipendyl | a neuroleptic azaphenothiazine; RN given refers to parent cpd | |
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| isothipendyl | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | |
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| pentazocine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Competitive Opioid Antagonists (Code: N0000175686) Partial Opioid Agonist/Antagonist (Code: N0000175688) Partial Opioid Agonists (Code: N0000175685) Adjuvants, Anesthesia (Code: D000759) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotic Antagonists (Code: D009292) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1967-07-24 FDA | |
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| cladribine | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) Deoxycytidine kinase (Organism: Homo sapiens, class: Kinase, accessions: P27707, gene: DCK, swissprot: DCK_HUMAN) | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Purine Antimetabolite (Code: N0000175712) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) | 1993-02-26 FDA | 2ZI9 2ZIA |
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| asenapine | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) | None | Atypical Antipsychotic (Code: N0000175430) alpha-adrenergic antagonist (Code: CHEBI:37890) beta-adrenergic antagonist (Code: CHEBI:35530) dopaminergic antagonist (Code: CHEBI:48561) psychotropic drug (Code: CHEBI:35471) serotonergic antagonist (Code: CHEBI:48279) second generation antipsychotic (Code: CHEBI:65191) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 2009-08-13 FDA | |
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| guaimesal | None | |
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| guacetisal | tolerated by patients with aspirin-asthma | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Expectorants (Code: D005100) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | |
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| butazopyridine | None | |
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| abacavir | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) | a carbocyclic nucleoside with potent selective anti-HIV activity; structure given in first source | Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175462) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) drug allergen (Code: CHEBI:88188) antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1999-07-08 EMA 1998-12-17 FDA | 3UPR 3VRI 3VRJ 5U98 |
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| methallenestril | None | |
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| thonzylamine | major descriptor (72-84); file-maintained to PYRIMIDINES | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | |
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| androstenedione | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Testosterone 17-beta-dehydrogenase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P37058, gene: HSD17B3, swissprot: DHB3_HUMAN) Testosterone 17-beta-dehydrogenase 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: O54939, gene: Hsd17b3, swissprot: DHB3_RAT) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. | 1EUP 1QYX 1XF0 2VCT 2VCV 3CAS 3EQM 3IW1 3NBR 3NHX 3NUV 3S79 3UZZ 4AT2 4JBT 4KQ8 4QCK 4QDC 4XO7 5JKV 5JL6 5JL7 5JL9 |
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| thenalidine | antihistaminic, antipruritic; RN in Chemline for thenalidine calcium: 67250-62-8; structure | |
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| retinol | Beta-lactoglobulin (Organism: Bos taurus, class: Unclassified, accessions: P02754, gene: LGB, swissprot: LACB_BOVIN) Retinol-binding protein 4 (Organism: Homo sapiens, class: Secreted, accessions: P02753, gene: RBP4, swissprot: RET4_HUMAN) Retinaldehyde-binding protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: P12271, gene: RLBP1, swissprot: RLBP1_HUMAN) Retinol-binding protein 3 (Organism: Homo sapiens, class: Surface antigen, accessions: P10745, gene: RBP3, swissprot: RET3_HUMAN) Retinal dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00352, gene: ALDH1A1, swissprot: AL1A1_HUMAN) Retinal dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: O94788, gene: ALDH1A2, swissprot: AL1A2_HUMAN) Retinol-binding protein 2 (Organism: Homo sapiens, class: Cytosolic other, accessions: P50120, gene: RBP2, swissprot: RET2_HUMAN) Retinoid-binding protein 7 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q96R05, gene: RBP7, swissprot: RET7_HUMAN) Retinol-binding protein 5 (Organism: Homo sapiens, class: Cytosolic other, accessions: P82980, gene: RBP5, swissprot: RET5_HUMAN) Retinol dehydrogenase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8NBN7, gene: RDH13, swissprot: RDH13_HUMAN) Retinol dehydrogenase 12 (Organism: Homo sapiens, class: Enzyme, accessions: Q96NR8, gene: RDH12, swissprot: RDH12_HUMAN) 11-cis retinol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: Q92781, gene: RDH5, swissprot: RDH1_HUMAN) Retinol-binding protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P09455, gene: RBP1, swissprot: RET1_HUMAN) Nuclear receptor subfamily 2 group C member 2 (Organism: Homo sapiens, class: Unclassified, accessions: P49116, gene: NR2C2, swissprot: NR2C2_HUMAN) | Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. | Vitamin A (Code: N0000006269) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) | 1953-02-20 FDA | 5LJC 5LJD 1AQB 1BRP 1CRB 1FBM 1FMJ 1FML 1GX8 1HBP 1IIU 1KQW 1KT3 1KT4 1KT5 1KT6 1KT7 1QAB 1RBP 2RCT 3BSZ 4QYN 4QZT 4QZU 5H8T 5HBS 5LJB 5LJE 5NU7 |
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| oxazepam | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) anxiolytic drug (Code: CHEBI:35474) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1965-06-04 FDA | |
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| ritodrine | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) | An adrenergic beta-2 agonist used to control PREMATURE LABOR. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Autonomic Agents (Code: D001337) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Sympathomimetics (Code: D013566) Tocolytic Agents (Code: D015149) | 1991-01-22 FDA | |
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| brallobarbital | None | |
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| fenticlor | Uracil-DNA glycosylase (Organism: Vaccinia virus (strain Western Reserve), class: Unclassified, accessions: P04303, gene: UNG, swissprot: UNG_VACCW) | None | antiinfective agent (Code: CHEBI:35441) drug allergen (Code: CHEBI:88188) | |
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| incadronic acid | Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Vacuolar-type proton translocating pyrophosphatase 1 (Organism: Trypanosoma brucei, class: Unclassified, accessions: Q8MTZ4, gene: PPase1, swissprot: Q8MTZ4_9TRYP) | increases serum 1,25-dihydroxyvitamin D in rats via stimulating renal 1-hydroxylase activity; structure given in first source | Bone Density Conservation Agents (Code: D050071) | 1997-01-01 PMDA | |
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| tenofovir | An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone. | antiviral drug (Code: CHEBI:36044) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 2009-11-05 FDA | 1T03 |
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| nifurtimox | A nitrofuran thiazine that has been used against TRYPANOSOMIASIS. | Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Trypanocidal Agents (Code: D014344) | 1967-01-01 YEAR INTRODUCED | |
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| sulmazole | cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) | None | cardiotonic drug (Code: CHEBI:38147) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) | |
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| rhodoquine | None | |
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| galantamine | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) | A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders. | Cholinesterase Inhibitor (Code: N0000175723) antidote to curare poisoning (Code: CHEBI:74530) cholinergic drug (Code: CHEBI:38323) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Nootropic Agents (Code: D018697) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 2001-02-28 FDA | 1DX6 1QTI 1W6R 1W76 2PH9 4EY6 |
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| etodolac | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE). | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1991-01-31 FDA | 5V0V |
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| zolmitriptan | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | an antimigraine compound; a serotonin (5HT)-1D receptor agonist | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) serotonergic agonist (Code: CHEBI:35941) vasoconstrictor agent (Code: CHEBI:50514) anti-inflammatory drug (Code: CHEBI:35472) Neurotransmitter Agents (Code: D018377) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 1997-11-25 FDA | |
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| naftifine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Squalene epoxidase (Organism: Trichophyton rubrum, class: Enzyme, accessions: Q4JEY0, gene: None, swissprot: Q4JEY0_TRIRU) Squalene monooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: Q14534, gene: SQLE, swissprot: ERG1_HUMAN) | allylamine der; RN given refers to unlabeled parent cpd | Allylamine (Code: N0000007522) Allylamine Antifungal (Code: N0000175874) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1988-02-29 FDA | |
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| cyproheptadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Mus musculus, class: GPCR, accessions: P34968, gene: Htr2c, swissprot: 5HT2C_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) D(2) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: P61168, gene: Drd2, swissprot: DRD2_MOUSE) Sodium-dependent serotonin transporter (Organism: Mus musculus, class: Transporter, accessions: Q60857, gene: Slc6a4, swissprot: SC6A4_MOUSE) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Histone-lysine N-methyltransferase SETD7 (Organism: Homo sapiens, class: Unclassified, accessions: Q8WTS6, gene: SETD7, swissprot: SETD7_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) | A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. | Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) serotonergic antagonist (Code: CHEBI:48279) antipruritic drug (Code: CHEBI:59683) anti-allergic agent (Code: CHEBI:50857) gastrointestinal drug (Code: CHEBI:55324) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1961-10-17 FDA | 5AYF |
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| proxazole | None | |
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| procyclidine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Anticholinergic (Code: N0000175574) muscarinic antagonist (Code: CHEBI:48876) antiparkinson drug (Code: CHEBI:48407) antidyskinesia agent (Code: CHEBI:66956) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | 1955-07-27 FDA | |
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| cycrimine | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | None | antiparkinson drug (Code: CHEBI:48407) muscarinic antagonist (Code: CHEBI:48876) antidyskinesia agent (Code: CHEBI:66956) | None FDA | |
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| chlorproguanil | dichloro-derivative of chloroguanide; RN given refers to parent cpd; structure | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | |
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| fospropofol | GABA-A receptor (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|Q16445|Q8N1C3|Q99928, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRG1|GABRG2|GABRG3, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN) | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 2008-12-12 FDA | |
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| piromidic acid | Antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | |
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| protiofate | None | |
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| difenpiramide | non-steroidal anti-inflammatory agent; do not confuse with herbicide diphenamid; RN given refers to parent cpd; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| estriol | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol. | 1X8V 3Q95 |
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| prasterone | Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) Glucose-6-phosphate 1-dehydrogenase (Organism: Trypanosoma brucei, class: Enzyme, accessions: Q9GRG7, gene: g6pd, swissprot: Q9GRG7_9TRYP) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. | Adjuvants, Immunologic (Code: D000276) Immunologic Factors (Code: D007155) | None FDA | 1COY 1E3R 1J99 1Q22 3DHE |
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| phenglutarimide | None | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neurotransmitter Agents (Code: D018377) | |
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| milverine | None | |
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| testosterone | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Steroid 5-alpha-reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P24008|P31214, gene: Srd5a1|Srd5a2, swissprot: S5A1_RAT|S5A2_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Constitutive androstane receptor (Organism: Mus musculus, class: Unclassified, accessions: O35627, gene: Nr1i3, swissprot: NR1I3_MOUSE) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. | Androgen (Code: N0000175824) Androgen Receptor Agonists (Code: N0000000146) Androstanes (Code: N0000008241) Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1972-07-13 FDA | 1AFS 1I9J 1J96 1JTV 1Q13 1VPO 2AM9 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 3BUR 3KDM 3UZZ 3ZQT 4HLW 4J6D 5JKW 5L94 |
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| methylestrenolone | was MH 1963-92; METHYLESTRENOLONE & METHYLNORTESTOSTERONE were see NORMETHANDROLONE 1963-92; use ESTRENES to search NORMETHANDROLONE 1966-92 | |
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| bupivacaine | Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Potassium voltage-gated channel subfamily D member 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UK17, gene: KCND3, swissprot: KCND3_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Potassium voltage-gated channel subfamily D member 3 (Organism: Mus musculus, class: Unclassified, accessions: Q9Z0V1, gene: Kcnd3, swissprot: KCND3_MOUSE) | A widely used local anesthetic agent. | Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) adrenergic antagonist (Code: CHEBI:37887) local anaesthetic (Code: CHEBI:36333) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1972-10-03 FDA | |
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| levobupivacaine | Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Potassium voltage-gated channel subfamily D member 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UK17, gene: KCND3, swissprot: KCND3_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | S-enantiomer of bupivacaine, local anaesthetic | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) adrenergic antagonist (Code: CHEBI:37887) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1999-08-05 FDA | |
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| methitural | None | |
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| ethylestrenol | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | An anabolic steroid with some progestational activity and little androgenic effect. | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1964-05-28 FDA | |
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| desalkylflurazepam | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | None | 1968-01-01 YEAR INTRODUCED | |
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| tetrazepam | None | Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | |
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| propallylonal | None | |
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| ciprofibrate | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) | Ciprofibrate is a new derivative of phenoxyisobutyric acid which has a marked hypolipidaemic action. It reduces both LDL and VLDL and hence the levels of triglyceride and cholesterol associated with these lipoprotein fractions. It also increases levels of HDL cholesterol. | antilipemic drug (Code: CHEBI:35679) Antimetabolites (Code: D000963) Carcinogens (Code: D002273) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Noxae (Code: D009676) Peroxisome Proliferators (Code: D020025) | 2009-06-18 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| tazanolast | None | |
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| adrafinil | induces hyperactivity | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Neurotransmitter Agents (Code: D018377) | |
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| rotraxate | None | |
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| hyoscyamine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) | The 3(S)-endo isomer of atropine. | Adjuvants, Anesthesia (Code: D000759) Anti-Arrhythmia Agents (Code: D000889) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 1869-01-01 YEAR INTRODUCED | |
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| atropine | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Muscarinic receptor M1 (Organism: Bos taurus, class: GPCR, accessions: Q8WMX0, gene: None, swissprot: Q8WMX0_BOVIN) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Muscarinic acetylcholine receptor M5 (Organism: Rattus norvegicus, class: GPCR, accessions: P08911, gene: Chrm5, swissprot: ACM5_RAT) Muscarinic acetylcholine receptor M2 (Organism: Mus musculus, class: GPCR, accessions: Q9ERZ4, gene: Chrm2, swissprot: ACM2_MOUSE) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Nicotinic acetylcholine receptor alpha 5 subunit (Organism: Musca domestica, class: Ion channel, accessions: A9XFY4, gene: nAChRalpha5, swissprot: A9XFY4_MUSDO) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M4 (Organism: Rattus norvegicus, class: GPCR, accessions: P08485, gene: Chrm4, swissprot: ACM4_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine. | Anticholinergic (Code: N0000175574) Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) Adjuvants, Anesthesia (Code: D000759) Anti-Arrhythmia Agents (Code: D000889) Anti-Asthmatic Agents (Code: D018927) anti-arrhythmia drug (Code: CHEBI:38070) anaesthesia adjuvant (Code: CHEBI:60807) mydriatic agent (Code: CHEBI:50513) parasympatholytic (Code: CHEBI:50370) bronchodilator agent (Code: CHEBI:35523) antidote to sarin poisoning (Code: CHEBI:136860) muscarinic antagonist (Code: CHEBI:48876) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 1960-09-15 FDA | 1TH6 2ARM 2X8O 2X8P 3OSH |
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| improsulfan | None | |
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| butaverine | None | |
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| dyclonine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) | minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) topical anaesthetic (Code: CHEBI:48425) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| caramiphen | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Lysosomal Pro-X carboxypeptidase (Organism: Homo sapiens, class: Enzyme, accessions: P42785, gene: PRCP, swissprot: PCP_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) | None | |
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| bencyclane | A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels. | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) | |
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| triclosan | Carbonyl reductase [NADPH] 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16152, gene: CBR1, swissprot: CBR1_HUMAN) Enoyl-[acyl-carrier-protein] reductase [NADPH] (Organism: Staphylococcus aureus, class: Enzyme, accessions: Q9RMI3, gene: fabI, swissprot: Q9RMI3_STAAU) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGR1, gene: inhA, swissprot: INHA_MYCTU) Enoyl-ACP reductase (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q9BJJ9, gene: FabI, swissprot: Q9BJJ9_PLAFA) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), class: Enzyme, accessions: Q5NGQ3, gene: fabI, swissprot: Q5NGQ3_FRATT) Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Organism: Staphylococcus aureus (strain MRSA252), class: Enzyme, accessions: Q6GI75, gene: fabI, swissprot: FABI_STAAR) Enoyl-acyl-carrier protein reductase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q965D5, gene: fabI, swissprot: Q965D5_PLAFA) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (Organism: Bacillus subtilis (strain 168), class: Enzyme, accessions: P54616, gene: fabI, swissprot: FABI_BACSU) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AEK4, gene: fabI, swissprot: FABI_ECOLI) Enoyl-acyl carrier reductase; Enoyl-acyl carrier reductase ENR (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q6UCJ9, gene: ENR, swissprot: Q6UCJ9_TOXGO) | A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action. | fungicide (Code: CHEBI:24127) antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antimetabolites (Code: D000963) Fatty Acid Synthesis Inhibitors (Code: D054872) Hypolipidemic Agents (Code: D000960) | 1997-07-11 FDA | 1C14 1D7O 1D8A 1NHG 1P45 1QG6 1QSG 1UH5 2B35 2O2S 2O2Y 2PD3 2QIO 2WYW 3AM3 3AM5 3F4B 3GR6 3NRC 3OID 3OIF 3P9T 3PJD 3PJE 3PJF 4ALI 4ALL 4M89 4NR0 4W9N 5IFL 5YCS |
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| quinethazone | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) | None | Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1963-04-10 FDA | |
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| nicoclonate | None | |
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| clofedanol | None | None FDA | |
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| chloropyramine | Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| cianidanol | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Arginase (Organism: Leishmania amazonensis, class: Enzyme, accessions: O96394, gene: None, swissprot: O96394_LEIAM) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) | An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. | None FDA | 3I52 4C94 4C9I |
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| bagrosin | None | |
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| trimethoprim | Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium falciparum, class: Enzyme, accessions: P13922, gene: None, swissprot: DRTS_PLAFK) Dihydrofolate reductase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0A017, gene: folA, swissprot: DYR_STAAU) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Dihydrofolate reductase (Organism: Neisseria gonorrhoeae, class: Enzyme, accessions: P04174, gene: folA, swissprot: DYR_NEIGO) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium berghei (strain Anka), class: Enzyme, accessions: Q27713, gene: None, swissprot: DRTS_PLABA) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Dihydrofolate reductase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0ABQ4, gene: folA, swissprot: DYR_ECOLI) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Dihydrofolate reductase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P07807, gene: DFR1, swissprot: DYR_YEAST) Dihydrofolate reductase (Organism: Candida albicans, class: Enzyme, accessions: P22906, gene: DFR1, swissprot: DYR_CANAX) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Cryptosporidium parvum, class: Unclassified, accessions: Q27552, gene: DHFR-TS, swissprot: Q27552_CRYPV) Dihydrofolate reductase (Organism: Mus musculus, class: Enzyme, accessions: P00375, gene: Dhfr, swissprot: DYR_MOUSE) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) Dihydrofolate reductase (Organism: Bacillus anthracis, class: Enzyme, accessions: Q81R22, gene: dfrA, swissprot: Q81R22_BACAN) Dihydrofolate reductase (Organism: Lactococcus lactis subsp. lactis (strain IL1403), class: Enzyme, accessions: Q59487, gene: folA, swissprot: DYR_LACLA) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Dihydrofolate reductase type 1 (Organism: Escherichia coli, class: Unclassified, accessions: P00382, gene: dhfrI, swissprot: DYR1_ECOLX) Dihydrofolate reductase (Organism: Mycobacterium avium, class: Enzyme, accessions: O30463, gene: folA, swissprot: O30463_MYCAV) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Trypanosoma brucei brucei, class: Enzyme, accessions: Q27783, gene: None, swissprot: DRTS_TRYBB) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: Q27793, gene: None, swissprot: DRTS_TRYCR) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Leishmania major, class: Enzyme, accessions: P07382, gene: None, swissprot: DRTS_LEIMA) Dihydrofolate reductase (Organism: Salmonella typhi, class: Unclassified, accessions: Q8Z9J9, gene: folA, swissprot: Q8Z9J9_SALTI) | A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. | Dihydrofolate Reductase Inhibitor Antibacterial (Code: N0000175489) Dihydrofolate Reductase Inhibitors (Code: N0000000191) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) drug allergen (Code: CHEBI:88188) antibacterial drug (Code: CHEBI:36047) diuretic (Code: CHEBI:35498) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Cytochrome P-450 CYP2C8 Inhibitors (Code: D065687) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) Metabolic Side Effects of Drugs and Substances (Code: D065606) Renal Agents (Code: D012076) | 1973-07-30 FDA | 1DG5 1DYR 2BFM 2W3A 2W3V 2W9G 2W9H 2W9S 3FL9 3FRB 3FRE 3JW3 3JW5 3N0H 3S3V 3TQ8 4G8Z 4KM2 4XT7 |
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| procaterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A long-acting beta-2-adrenergic receptor agonist. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) | |
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| sulcaine | None | |
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| sultiame | Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | None | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 2Q1Q |
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| methylhomatropine | None | muscarinic antagonist (Code: CHEBI:48876) anti-ulcer drug (Code: CHEBI:49201) antispasmodic drug (Code: CHEBI:53784) | 1943-03-23 FDA | |
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| oxabolone | None | |
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| suxamethonium | Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Muscle-type nicotinic acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q04844|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNE|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHE_HUMAN|ACHG_HUMAN) | A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. | Depolarizing Neuromuscular Blocker (Code: N0000175719) Neuromuscular Depolarizing Blockade (Code: N0000175733) muscle relaxant (Code: CHEBI:51371) drug allergen (Code: CHEBI:88188) neuromuscular agent (Code: CHEBI:51372) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Depolarizing Agents (Code: D009467) Peripheral Nervous System Agents (Code: D018373) | 1952-08-20 FDA | 2HA2 2HA6 |
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| azatadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) | indulian (UD 21;71k) is dimaleate; do not confuse with AZACITIDINE | H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1977-03-29 FDA | |
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| androstanolone | Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Androgen receptor (Organism: Mus musculus, class: Transcription factor, accessions: P19091, gene: Ar, swissprot: ANDR_MOUSE) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Mineralocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P22199, gene: Nr3c2, swissprot: MCR_RAT) Progesterone receptor (Organism: Oryctolagus cuniculus, class: Transcription factor, accessions: P06186, gene: PGR, swissprot: PRGR_RABIT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. | Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 4OEA 1D2S 1DHT 1F5F 1I37 1I38 1KDK 1KDM 1T5Z 1T63 1T65 1T73 1T74 1T76 1T79 1T7F 1T7M 1T7R 1T7T 1XJ7 2AMA 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2QPY 2Z4J 3DEY 3KLM 3L3X 3L3Z 4K7A 4OED 4OEY 4OEZ 4OFR 4OFU 5JJM |
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| androstenediol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES). | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 3KLP |
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| mepiperphenidol | None | |
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| carbinoxamine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | antihistamine with anticholinergic and sedative properties | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) muscarinic antagonist (Code: CHEBI:48876) antiparkinson drug (Code: CHEBI:48407) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1974-12-27 FDA | |
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| sulfamidochrysoidine | None | antibacterial drug (Code: CHEBI:36047) | |
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| befunolol | synonym BFE 60 refers to HCl; RN given refers to parent cpd; structure | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Agonists (Code: D000318) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | |
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| eseridine | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) | None | |
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| fasudil | C-C motif chemokine 2 (Organism: Homo sapiens, class: Cytokine, accessions: P13500, gene: CCL2, swissprot: CCL2_HUMAN) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) Rho-associated protein kinase 2 (Organism: Rattus norvegicus, class: Kinase, accessions: Q62868, gene: Rock2, swissprot: ROCK2_RAT) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) cAMP-dependent protein kinase catalytic subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P17612, gene: PRKACA, swissprot: KAPCA_HUMAN) | intracellular calcium antagonist | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Protein Kinase Inhibitors (Code: D047428) Vasodilator Agents (Code: D014665) | 1995-06-30 PMDA | 1Q8W 2ESM 2F2U 2GNI 3TKU 5LCP 5VEF |
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| pecilocin | fungicidal antibiotic produced by Paecilomyces varioti Bainier var. antibioticus; structure | |
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| eucatropine | None | |
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| cyclopentolate | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) | A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. | mydriatic agent (Code: CHEBI:50513) parasympatholytic (Code: CHEBI:50370) muscarinic antagonist (Code: CHEBI:48876) diagnostic agent (Code: CHEBI:33295) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | 1974-07-31 FDA | |
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| levobunolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Beta-3 adrenergic receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P26255, gene: Adrb3, swissprot: ADRB3_RAT) | The L-Isomer of bunolol. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) antiglaucoma drug (Code: CHEBI:39456) beta-adrenergic antagonist (Code: CHEBI:35530) Autonomic Agents (Code: D001337) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1985-12-19 FDA | |
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| butinoline | None | |
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| perlapine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) | None | |
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| penbutolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Alpha-1-acid glycoprotein 1 (Organism: Homo sapiens, class: Secreted, accessions: P02763, gene: ORM1, swissprot: A1AG1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A nonselective beta-blocker used as an antihypertensive and an antianginal agent. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1987-12-30 FDA | |
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| terbinafine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Squalene monooxygenase (Organism: Rattus norvegicus, class: Unclassified, accessions: P52020, gene: Sqle, swissprot: ERG1_RAT) Squalene monooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: Q14534, gene: SQLE, swissprot: ERG1_HUMAN) Squalene epoxidase (Organism: Trichophyton rubrum, class: Enzyme, accessions: Q4JEY0, gene: None, swissprot: Q4JEY0_TRIRU) | synthetic antifungal agent inhibiting fungal squalene epoxidase; structure given in first source; RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 1/85; TDT-067 is terbinafine in Transferome | Allylamine (Code: N0000007522) Allylamine Antifungal (Code: N0000175874) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Enzyme Inhibitors (Code: D004791) | 1992-12-30 FDA | |
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| melitracen | None | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| lobenzarit | prevents autoimmune kidney disease in hybrid mice; RN given refers to parent cpd | Adjuvants, Immunologic (Code: D000276) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| zomepirac | Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) cardiovascular drug (Code: CHEBI:35554) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 3R8H 4JQ3 |
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| leucinocaine | None | |
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| ambucetamide | None | |
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| butedronic acid | None | |
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| brimonidine | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) | A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-2 Receptor Agonists (Code: D058647) Adrenergic alpha-Agonists (Code: D000316) adrenergic agonist (Code: CHEBI:37886) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic agonist (Code: CHEBI:35569) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1996-09-06 FDA | |
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| cloranolol | tobanum is for (+-)-isomer, HCl salt; RN given refers to parent cpd | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| edetic acid | Beta-lactamase (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q79MP6, gene: blaIMP-1, swissprot: Q79MP6_PSEAI) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Crotalus adamanteus, class: Unclassified, accessions: J3SE37, gene: None, swissprot: J3SE37_CROAD) Beta-lactamase VIM-1; Class B carbapenemase VIM-1; Metallo-beta-lactamase; Metallo-beta-lactamase VIM-1; Metallobeta-lactamase; VIM-1; VIM-1 metallo-beta lactamase; VIM-1 metallo-beta-lactamase; VIM-1 (Organism: Pseudomonas aeruginosa, class: Unclassified, accessions: Q9XAY4, gene: blaVIM, swissprot: Q9XAY4_PSEAI) Ceramide glucosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q16739, gene: UGCG, swissprot: CEGT_HUMAN) lead (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) calcium (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) | A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive. | Lead Chelating Activity (Code: N0000175962) Lead Chelator (Code: N0000175963) Anti-coagulant (Code: N0000175980) Decreased Coagulation Factor Activity (Code: N0000008556) Calcium Chelating Activity (Code: N0000175089) antidote (Code: CHEBI:50247) anticoagulant (Code: CHEBI:50249) Anticoagulants (Code: D000925) Calcium Chelating Agents (Code: D065096) Chelating Agents (Code: D002614) Food Additives (Code: D005503) Hematologic Agents (Code: D006401) Sequestering Agents (Code: D064449) | 1953-07-16 FDA | 1NNF 1ZLQ 2AXN 3L7K 3L7M 3RNJ 3T8N 3WFA 4OES 5DSG 5FX3 5JHD 5L8D 5MWU 5N0N 5UIG 5UWC 6EID |
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| tiamiprine | None | |
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| bifluranol | None | |
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| carteolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) beta-adrenergic antagonist (Code: CHEBI:35530) antihypertensive agent (Code: CHEBI:35674) sympatholytic agent (Code: CHEBI:66991) antiglaucoma drug (Code: CHEBI:39456) anti-arrhythmia drug (Code: CHEBI:38070) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1988-12-28 FDA | |
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| dimetindene | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies. | Anti-Allergic Agents (Code: D018926) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| perfosfamide | None | |
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| pimethixene | Transcriptional activator protein luxR (Organism: Aliivibrio fischeri, class: Unclassified, accessions: P12746, gene: luxR, swissprot: LUXR_ALIFS) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) | None | |
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| oxaprozin | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) | None | Cyclooxygenase Inhibitors (Code: N0000000160) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) analgesic (Code: CHEBI:35480) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1992-10-29 FDA | |
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| ondansetron | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563, gene: Htr3a, swissprot: 5HT3A_RAT) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Serotonin 3 receptor (5HT3) (Organism: Mus musculus, class: Ion channel, accessions: P23979|Q9JHJ5, gene: Htr3a|Htr3b, swissprot: 5HT3A_MOUSE|5HT3B_MOUSE) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Rattus norvegicus, class: GPCR, accessions: P28565, gene: Htr1d, swissprot: 5HT1D_RAT) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Gastrin/cholecystokinin type B receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30553, gene: Cckbr, swissprot: GASR_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) 5-hydroxytryptamine receptor 3B (Organism: Homo sapiens, class: Ion channel, accessions: O95264, gene: HTR3B, swissprot: 5HT3B_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: Q62758, gene: Htr4, swissprot: 5HT4R_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. | Serotonin 3 Receptor Antagonists (Code: N0000175817) Serotonin-3 Receptor Antagonist (Code: N0000175818) Anti-Anxiety Agents (Code: D014151) Antiemetics (Code: D000932) Antipruritics (Code: D000982) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dermatologic Agents (Code: D003879) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) | 1991-01-04 FDA | |
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| anastrozole | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) | trade name; aromatase inhibitor; structure given in first source | Aromatase Inhibitor (Code: N0000175563) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 1995-12-27 FDA | |
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| pramocaine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1976-08-13 FDA | 4Y0Q 4Y0R 4Y0S |
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| mabuterol | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| butoxycaine | None | |
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| amitriptylinoxide | Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) | None | |
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| dimazole | None | |
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| prozapine | None | |
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| pramiverine | long acting cholinolytic proposed for gastrointestinal spasms; minor descriptor (78-84); on-line & Index Medicus search CYCLOHEXYLAMINES (78-84); RN given refers to parent cpd | |
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| butriptyline | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | a tricyclic antianxiety and antidepressive agent similar to, but with less side effects than amitriptyline; minor descriptor (75-86); on line & INDEX MEDICUS search DIBENZOCYCLOHEPTENES (75-86); RN given refers to parent cpd | Anti-Anxiety Agents (Code: D014151) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| budipine | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) | None | Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) | |
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| lumiracoxib | Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | A selective non-steroidal anti-inflammatory drug (NSAID) that belongs to the group cyclo-oxygenase 2 (COX-2) inhibitors. It blocks the COX-2 enzyme, resulting in a reduction in the production of prostaglandins, substances that are involved in the inflammation process. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2003-09-12 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | 4IIZ 4IK6 4OTY 4RRW 4RRX 4RRZ |
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| iomeglamic acid | None | |
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| lidofenin | None | |
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| rosoxacin | None | antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) | |
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| sulfametomidine | None | |
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| sulfacytine | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase; Dihydropteroate synthetase (Organism: Plasmodium falciparum, class: Kinase, accessions: Q25704, gene: PPPK-DHPS, swissprot: Q25704_PLAFA) | None | 1975-09-12 FDA | |
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| troxipide | None | |
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| alosetron | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | None | Serotonin 3 Receptor Antagonists (Code: N0000175817) Serotonin-3 Receptor Antagonist (Code: N0000175818) gastrointestinal drug (Code: CHEBI:55324) serotonergic antagonist (Code: CHEBI:48279) antiemetic (Code: CHEBI:50919) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 2000-02-09 FDA | |
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| norgestrienone | A synthetic steroid with progestational and contraceptive activities. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | |
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| propoxycaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017) | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| proparacaine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | Local Anesthesia (Code: N0000175976) Local Anesthetic (Code: N0000175539) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1953-07-01 FDA | |
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| eburnamonine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| vinburnine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) | None | |
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| noxiptiline | proposed tricyclic antidepressent; minor descriptor (75-86); on line & INDEX MEDICUS search DIBENZOCYCLOHEPTENES (75-86); RN given refers to parent cpd | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| trimipramine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | Tricyclic antidepressant similar to IMIPRAMINE, but with more antihistaminic and sedative properties. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1979-06-12 FDA | |
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| dimetacrine | Apical membrane antigen 1 (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q7KQK5, gene: AMA1, swissprot: Q7KQK5_PLAF7) | minor descriptor (75-84); on-line & Index Medicus search ACRIDINES (75-84); RN given refers to parent cpd without isomeric designation | |
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| sodium tetradecyl sulfate | An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins. | detergent (Code: CHEBI:27780) Cardiovascular Agents (Code: D002317) Pharmaceutical Solutions (Code: D019999) Sclerosing Solutions (Code: D012597) Surface-Active Agents (Code: D013501) | 1946-08-13 FDA | |
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| sodium myristyl sulfate | None | |
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| indobufen | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | thromboxane A2 antagonist | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Peripheral Nervous System Agents (Code: D018373) Platelet Aggregation Inhibitors (Code: D010975) Sensory System Agents (Code: D018689) | 1984-01-01 YEAR INTRODUCED | |
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| floredil | None | |
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| tiadenol | None | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| estazolam | GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) anxiolytic drug (Code: CHEBI:35474) anticonvulsant (Code: CHEBI:35623) GABA modulator (Code: CHEBI:50268) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1990-12-26 FDA | |
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| bucloxic acid | water insoluble anti-inflammatory agent with analgesic & antipyretic properties | Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | |
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| glyconiazide | None | |
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| azidamfenicol | None | |
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| nimetazepam | None | Anti-Anxiety Agents (Code: D014151) sedative (Code: CHEBI:35717) antispasmodic drug (Code: CHEBI:53784) anticonvulsant (Code: CHEBI:35623) GABA modulator (Code: CHEBI:50268) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| mebendazole | Calmodulin-domain protein kinase 1 (Organism: Toxoplasma gondii, class: Kinase, accessions: Q9BJF5, gene: CDPK1, swissprot: Q9BJF5_TOXGO) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Tubulin (Organism: Echinococcus granulosus, class: Structural, accessions: C4PKY4|C4PKZ2|C4PKZ6, gene: None, swissprot: C4PKY4_ECHGR|C4PKZ2_ECHGR|C4PKZ6_ECHGR) Tubulin (Organism: Ascaris suum, class: Structural, accessions: F1L005|F1L4P8|F1L5G6|F1L7U3|F1L7Y0|F1L8A5|F1LCS0, gene: None, swissprot: F1L005_ASCSU|F1L4P8_ASCSU|F1L5G6_ASCSU|F1L7U3_ASCSU|F1L7Y0_ASCSU|F1L8A5_ASCSU|F1LCS0_ASCSU) | A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES. | Antihelminthic (Code: N0000175481) Anthelmintics (Code: D000871) antinematodal drug (Code: CHEBI:35444) Anti-Infective Agents (Code: D000890) Antimitotic Agents (Code: D050256) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) | 1974-06-28 FDA | |
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| esmolol | Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | a beta1-selective (cardioselective) adrenergic receptor blocking agent with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilizing activity at therapeutic dosages | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) beta-adrenergic antagonist (Code: CHEBI:35530) anti-arrhythmia drug (Code: CHEBI:38070) Neurotransmitter Agents (Code: D018377) | 1986-12-31 FDA | |
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| dibenzepin | None | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| sumatriptan | 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Gorilla gorilla gorilla, class: GPCR, accessions: Q9N2B7, gene: HTR1B, swissprot: 5HT1B_GORGO) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 1D (Organism: Rattus norvegicus, class: GPCR, accessions: P28565, gene: Htr1d, swissprot: 5HT1D_RAT) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Mus musculus, class: GPCR, accessions: Q64264, gene: Htr1a, swissprot: 5HT1A_MOUSE) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Sus scrofa, class: GPCR, accessions: P79400, gene: HTR1D, swissprot: 5HT1D_PIG) 5-hydroxytryptamine 1D receptor (Organism: Bos taurus, class: Unclassified, accessions: Q8MI13, gene: 5htr1d, swissprot: Q8MI13_BOVIN) 5-hydroxytryptamine receptor 5A (Organism: Mus musculus, class: Unclassified, accessions: P30966, gene: Htr5a, swissprot: 5HT5A_MOUSE) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) | A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS. | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) vasoconstrictor agent (Code: CHEBI:50514) serotonergic agonist (Code: CHEBI:35941) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Vasoconstrictor Agents (Code: D014662) | 1992-12-28 FDA | |
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| difemetorex | None | |
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| pridinol | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | antispasmodic & muscle relaxant; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7539 | muscle relaxant (Code: CHEBI:51371) antiparkinson drug (Code: CHEBI:48407) | |
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| normethadone | None | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | |
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| picoperine | None | |
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| tertatolol | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Beta-3 adrenergic receptor (Organism: Mus musculus, class: Unclassified, accessions: P25962, gene: Adrb3, swissprot: ADRB3_MOUSE) Beta-3 adrenergic receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P26255, gene: Adrb3, swissprot: ADRB3_RAT) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| pizotifen | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) serotonergic antagonist (Code: CHEBI:48279) muscarinic antagonist (Code: CHEBI:48876) histamine antagonist (Code: CHEBI:37956) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | |
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| dosulepin | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) | A tricyclic antidepressant with some tranquilizing action. | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1962-01-01 YEAR INTRODUCED | |
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| diisopromine | None | |
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| chlorothiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) | A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Increased Diuresis (Code: N0000175359) Thiazide Diuretic (Code: N0000175419) Thiazides (Code: N0000166469) diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1958-09-04 FDA | |
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| chloropyrilene | not carcinogenic; RN given refers to parent cpd; structure given in first source | |
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| sulfarside | None | |
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| meclofenamic acid | Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Fatty acid-binding protein, intestinal (Organism: Homo sapiens, class: Cytosolic other, accessions: P12104, gene: FABP2, swissprot: FABPI_HUMAN) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Aldo-keto reductase family 1 member C1 (Organism: Homo sapiens, class: Enzyme, accessions: Q04828, gene: AKR1C1, swissprot: AK1C1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antirheumatic drug (Code: CHEBI:35842) antineoplastic agent (Code: CHEBI:35610) anticonvulsant (Code: CHEBI:35623) analgesic (Code: CHEBI:35480) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1980-06-25 FDA | 3R6I 4N6P 4QKN 5IKQ |
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| diclofenac | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) UDP-glucuronosyltransferase 1-10 (Organism: Homo sapiens, class: Enzyme, accessions: Q9HAW8, gene: UGT1A10, swissprot: UD110_HUMAN) Interleukin-8 (Organism: Homo sapiens, class: Cytokine, accessions: P10145, gene: CXCL8, swissprot: IL8_HUMAN) UDP-glucuronosyltransferase 1-6 (Organism: Homo sapiens, class: Enzyme, accessions: P19224, gene: UGT1A6, swissprot: UD16_HUMAN) UDP-glucuronosyltransferase 1-7 (Organism: Homo sapiens, class: Enzyme, accessions: Q9HAW7, gene: UGT1A7, swissprot: UD17_HUMAN) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) UDP-glucuronosyltransferase 1-9 (Organism: Homo sapiens, class: Enzyme, accessions: O60656, gene: UGT1A9, swissprot: UD19_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) C-X-C chemokine receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P25024, gene: CXCR1, swissprot: CXCR1_HUMAN) UDP-glucuronosyltransferase 1-1 (Organism: Homo sapiens, class: Enzyme, accessions: P22309, gene: UGT1A1, swissprot: UD11_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Acid-sensing ion channel 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UHC3, gene: ASIC3, swissprot: ASIC3_HUMAN) Aldo-keto reductase family 1 member B10 (Organism: Homo sapiens, class: Enzyme, accessions: O60218, gene: AKR1B10, swissprot: AK1BA_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. | Decreased Prostaglandin Production (Code: N0000008836) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) drug allergen (Code: CHEBI:88188) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1988-07-28 FDA | 1DVX 1NR6 1PXX 1SV9 2B17 2WEK 3CFQ 3IB0 3N8Y 4OJ4 4UBS 4XTA 4Z69 4ZBQ 4ZBR 5DBY 5U1R |
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| tritiozine | None | |
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| trifluridine | Thymidine kinase (Organism: Cercopithecine herpesvirus 1, class: Kinase, accessions: A3RLP8, gene: UL23, swissprot: A3RLP8_CHV1) Thymidylate kinase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WKE1, gene: tmk, swissprot: KTHY_MYCTU) | An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557) | Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antiviral (Code: N0000175466) antiviral drug (Code: CHEBI:36044) antineoplastic agent (Code: CHEBI:35610) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Nucleoside Metabolic Inhibitor (Code: N0000175595) Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Noxae (Code: D009676) | 1980-04-10 FDA | |
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| bermoprofen | None | |
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| exiproben | None | |
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| propizepine | None | |
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| glycyclamide | None | |
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| bentazepam | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| exemestane | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | a hormonal antineoplastic agent | Aromatase Inhibitor (Code: N0000175563) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 1999-10-21 FDA | 3S7S |
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| ethinylestradiol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) | A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES. | Estrogen (Code: N0000175825) Estrogen Receptor Agonists (Code: N0000000100) xenoestrogen (Code: CHEBI:76988) Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1943-06-25 FDA | 4X1F 4X1G |
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| palonosetron | Serotonin 3 receptor (5HT3) (Organism: Homo sapiens, class: Ion channel, accessions: O95264|P46098, gene: HTR3A|HTR3B, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | an antiemetic and antinauseant agent, it is a serotonin subtype 3 (5-HT3) receptor antagonist with a strong binding affinity for this receptor and little or no affinity for other receptors | Serotonin 3 Receptor Antagonists (Code: N0000175817) Serotonin-3 Receptor Antagonist (Code: N0000175818) antiemetic (Code: CHEBI:50919) serotonergic antagonist (Code: CHEBI:48279) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 2005-03-22 EMA 2003-07-25 FDA | |
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| dimevamide | None | |
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| parathiazine | None | |
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| methdilazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | None FDA | |
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| disulfiram | Aldehyde dehydrogenase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P05091, gene: ALDH2, swissprot: ALDH2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) C-C chemokine receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P51681, gene: CCR5, swissprot: CCR5_HUMAN) C-X-C chemokine receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P25025, gene: CXCR2, swissprot: CXCR2_HUMAN) C-C chemokine receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P41597, gene: CCR2, swissprot: CCR2_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) C-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P51679, gene: CCR4, swissprot: CCR4_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Monoglyceride lipase (Organism: Homo sapiens, class: Enzyme, accessions: Q99685, gene: MGLL, swissprot: MGLL_HUMAN) Aldehyde dehydrogenase, mitochondrial (Organism: Rattus norvegicus, class: Enzyme, accessions: P11884, gene: Aldh2, swissprot: ALDH2_RAT) Translocator protein (Organism: Homo sapiens, class: Transporter, accessions: P30536, gene: TSPO, swissprot: TSPO_HUMAN) Bifunctional protein GlmU (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WMN3, gene: glmU, swissprot: GLMU_MYCTU) | A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. | Acetyl Aldehyde Dehydrogenase Inhibitors (Code: N0000000183) Aldehyde Dehydrogenase Inhibitor (Code: N0000175679) Acetaldehyde Dehydrogenase Inhibitors (Code: D065086) Alcohol Deterrents (Code: D000427) angiogenesis inhibitor (Code: CHEBI:48422) fungicide (Code: CHEBI:24127) antineoplastic agent (Code: CHEBI:35610) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) | 1951-08-28 FDA | |
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| fenclofenac | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| enilconazole | Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | None | antifungal agrochemical (Code: CHEBI:86328) Fungicides, Industrial (Code: D005659) Pesticides (Code: D010575) | |
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| nelarabine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | prodrug of ara-G | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) | 2005-10-28 FDA | |
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| ibuprofen piconol | pyridyl ester of ibuprofen; structure given in first source; RN given refers to cpd without isomeric designation | |
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| glybuzole | None | |
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| imipramine oxide | None | |
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| tolindate | None | |
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| duloxetine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA. | Norepinephrine Uptake Inhibitors (Code: N0000000102) Serotonin and Norepinephrine Reuptake Inhibitor (Code: N0000175749) Serotonin Uptake Inhibitors (Code: N0000000109) Analgesics (Code: D000700) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Serotonin and Noradrenaline Reuptake Inhibitors (Code: D000068760) | 2004-08-03 FDA | 4MM6 4MMD |
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| dimantine | None | |
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| hydrochlorothiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. | Increased Diuresis (Code: N0000175359) Thiazide Diuretic (Code: N0000175419) Thiazides (Code: N0000166469) diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1959-02-12 FDA | 3IJX 3IK6 |
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| amlexanox | Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) | The mechanism of action by which amlexanox accelerates healing of aphthous ulcers is unknown. In vitro studies have demonstrated amlexanox to be a potent inhibitor of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells. | Decreased Histamine Release (Code: N0000175628) Anti-Allergic Agents (Code: D018926) anti-allergic agent (Code: CHEBI:50857) anti-ulcer drug (Code: CHEBI:49201) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 1996-12-17 FDA | 4WBO |
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| metochalcone | ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) | None | |
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| piribedil | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) | A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist. | Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | |
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| nialamide | An MAO inhibitor that is used as an antidepressive agent. | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) | |
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| zaltoprofen | None | None PMDA | |
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| artemether | quinghaosu derivative | Anthelmintics (Code: D000871) antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Antiprotozoal Agents (Code: D000981) Coccidiostats (Code: D003049) Schistosomicides (Code: D012556) | 2009-04-07 FDA | |
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| phenacaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | |
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| carazolol | Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-3 adrenergic receptor (Organism: Mus musculus, class: Unclassified, accessions: P25962, gene: Adrb3, swissprot: ADRB3_MOUSE) Beta-3 adrenergic receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P26255, gene: Adrb3, swissprot: ADRB3_RAT) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | 2RH1 2YCW 4GBR 5D5A 5D5B 5D6L 5JQH 5X7D |
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| minaprine | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure | antidepressant (Code: CHEBI:35469) serotonin uptake inhibitor (Code: CHEBI:50949) dopamine uptake inhibitor (Code: CHEBI:51039) cholinergic drug (Code: CHEBI:38323) antiparkinson drug (Code: CHEBI:48407) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| piprozolin | 10 articles in Arzneim Forsch 27(2b):467;1977; structure | |
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| methestrol | None | |
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| norethynodrel | Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1961-03-09 FDA | |
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| norethisterone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211|Q62986, gene: Esr1|Esr2, swissprot: ESR1_RAT|ESR2_RAT) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception. | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) synthetic oral contraceptive (Code: CHEBI:49326) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1962-05-21 FDA | 1SQN 2W8Y |
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| benzestrol | None | |
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| alimemazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) | A phenothiazine derivative that is used as an antipruritic. | Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | None FDA | |
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| diethazine | Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) | phenothiazine derivative anti-Parkinson agent with anticholinergic and antihistaminic actions; is effective against Parkinson tremor; minor descriptor (75-86); on-line & INDEX MEDICUS search PHENOTHIAZINES (75-86); RN given refers to cpd without isomeric designation | |
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| ricinoleic acid | None | |
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| rosaprostol | None | Anti-Ulcer Agents (Code: D000897) Expectorants (Code: D005100) Gastrointestinal Agents (Code: D005765) Respiratory System Agents (Code: D019141) | |
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| imipenem | Beta-lactamase GES-13 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: D1MIX9, gene: blaGES-13, swissprot: D1MIX9_PSEAI) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) Penicillin-binding protein 1 (Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18), class: Enzyme, accessions: A1KS91, gene: ponA, swissprot: A1KS91_NEIMF) Penicillin-binding protein 4 (Organism: Staphylococcus aureus, class: Enzyme, accessions: Q5D1E9, gene: None, swissprot: Q5D1E9_STAAU) | Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1985-11-26 FDA | |
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| metopon | None | |
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| hydrocodone | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant. | Opioid Agonist (Code: N0000175690) Opioid Agonists (Code: N0000000174) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) mu-opioid receptor agonist (Code: CHEBI:55322) opioid analgesic (Code: CHEBI:35482) antitussive (Code: CHEBI:51177) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | 1943-03-23 FDA | |
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| codeine | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) | An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) antitussive (Code: CHEBI:51177) opioid receptor agonist (Code: CHEBI:60606) prodrug (Code: CHEBI:50266) opioid analgesic (Code: CHEBI:35482) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | 1952-01-21 FDA | |
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| buphenine | Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) | A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Sympathomimetics (Code: D013566) Tocolytic Agents (Code: D015149) Vasodilator Agents (Code: D014665) | |
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| thiazinam | None | |
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| palmidrol | Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) Cannabinoid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P34972, gene: CNR2, swissprot: CNR2_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) G-protein coupled receptor 55 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y2T6, gene: GPR55, swissprot: GPR55_HUMAN) | a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) anti-inflammatory drug (Code: CHEBI:35472) antihypertensive agent (Code: CHEBI:35674) neuroprotective agent (Code: CHEBI:63726) anticonvulsant (Code: CHEBI:35623) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Antiviral Agents (Code: D000998) Cannabinoid Receptor Agonists (Code: D063386) Cannabinoid Receptor Modulators (Code: D063385) Central Nervous System Agents (Code: D002491) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| lanatoside C | None | |
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| traxanox | None | Antirheumatic Agents (Code: D018501) Diuretics (Code: D004232) Gout Suppressants (Code: D006074) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Natriuretic Agents (Code: D045283) Neurotransmitter Agents (Code: D018377) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) | |
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| chlordiazepoxide | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Cholecystokinin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30551|P30553, gene: Cckar|Cckbr, swissprot: CCKAR_RAT|GASR_RAT) GABA-A receptor; anion channel (Organism: Bos taurus, class: Ion channel, accessions: P08219|P08220|P10063|P10064|P20237|P22300, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRB1|GABRG2, swissprot: GBRA1_BOVIN|GBRA2_BOVIN|GBRA3_BOVIN|GBRA4_BOVIN|GBRB1_BOVIN|GBRG2_BOVIN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Translocator protein (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P16257, gene: Tspo, swissprot: TSPO_RAT) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Cholecystokinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P32238|P32239, gene: CCKAR|CCKBR, swissprot: CCKAR_HUMAN|GASR_HUMAN) Thyrotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P34981, gene: TRHR, swissprot: TRFR_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Thyrotropin-releasing hormone receptor (Organism: Mus musculus, class: GPCR, accessions: P21761, gene: Trhr, swissprot: TRFR_MOUSE) Thyrotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q01717, gene: Trhr, swissprot: TRFR_RAT) | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Adjuvants, Anesthesia (Code: D000759) Anti-Anxiety Agents (Code: D014151) anaesthesia adjuvant (Code: CHEBI:60807) sedative (Code: CHEBI:35717) anxiolytic drug (Code: CHEBI:35474) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1960-02-24 FDA | |
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| metoclopramide | 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Serotonin 3 receptor (5HT3) (Organism: Mus musculus, class: Ion channel, accessions: P23979|Q9JHJ5, gene: Htr3a|Htr3b, swissprot: 5HT3A_MOUSE|5HT3B_MOUSE) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) 5-hydroxytryptamine receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: Q62758, gene: Htr4, swissprot: 5HT4R_RAT) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Serotonin 3 (5-HT3) receptor (Organism: Homo sapiens, class: Ion channel, accessions: A5X5Y0|O95264|P46098|Q70Z44|Q8WXA8, gene: HTR3A|HTR3B|HTR3C|HTR3D|HTR3E, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN|5HT3C_HUMAN|5HT3D_HUMAN|5HT3E_HUMAN) D(2) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: P61168, gene: Drd2, swissprot: DRD2_MOUSE) 5-hydroxytryptamine receptor 4 (Organism: Mus musculus, class: Unclassified, accessions: P97288, gene: Htr4, swissprot: 5HT4R_MOUSE) | A dopamine D2 antagonist that is used as an antiemetic. | Dopamine D2 Antagonists (Code: N0000175799) Dopamine-2 Receptor Antagonist (Code: N0000175800) antiemetic (Code: CHEBI:50919) dopaminergic antagonist (Code: CHEBI:48561) gastrointestinal drug (Code: CHEBI:55324) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Dopamine D2 Receptor Antagonists (Code: D065127) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1979-02-07 FDA | |
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| tazobactam | Beta-lactamase TEM (Organism: Escherichia coli, class: Enzyme, accessions: P62593, gene: bla; blaT-3; blaT-4;, swissprot: BLAT_ECOLX) Beta-lactamase 1 (Organism: Bacillus cereus, class: Enzyme, accessions: P10424, gene: penPC, swissprot: BLA1_BACCE) Beta-lactamase GES-13 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: D1MIX9, gene: blaGES-13, swissprot: D1MIX9_PSEAI) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: P05193, gene: ampC, swissprot: AMPC_CITFR) Beta-lactamase (Organism: Citrobacter gillenii, class: Enzyme, accessions: A4KCT8, gene: BlaGIL-1, swissprot: A4KCT8_9ENTR) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: P05364, gene: ampC, swissprot: AMPC_ENTCL) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: Q6W9J1, gene: blaTEM-1, swissprot: Q6W9J1_ENTCL) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q9EXV5, gene: blaUOE-1, swissprot: Q9EXV5_ECOLX) Carbapenem-hydrolizing beta-lactamase SFC-1 (Organism: Serratia fonticola, class: Enzyme, accessions: Q6JP75, gene: None, swissprot: Q6JP75_SERFO) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q6GWS8, gene: blaTEM-125, swissprot: Q6GWS8_ECOLX) Carbepenem-hydrolyzing beta-lactamase KPC (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q9F663, gene: bla, swissprot: BLKPC_KLEPN) Beta-lactamase (Organism: Salmonella enterica subsp. enterica serovar Westhampton, class: Enzyme, accessions: Q2XPY6, gene: blaCTX-M-53, swissprot: Q2XPY6_SALET) Beta-lactamase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: P24735, gene: ampC, swissprot: AMPC_PSEAE) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: A0ZX81, gene: blaSHV-72, swissprot: A0ZX81_KLEPN) IMI-1; IMI-1 carbapenemase (Organism: Enterobacter cloacae, class: Enzyme, accessions: Q46991, gene: imiA, swissprot: Q46991_ENTCL) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) Beta-lactamase (Organism: Burkholderia cenocepacia, class: Enzyme, accessions: B8R6A5, gene: penB1, swissprot: B8R6A5_9BURK) Beta-lactamase SHV-1 (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: P0AD64, gene: bla, swissprot: BLA1_KLEPN) Beta-lactamase (Organism: Morganella morganii, class: Enzyme, accessions: P94958, gene: ampC, swissprot: AMPC_MORMO) Beta-lactamase (Organism: Bacillus clausii, class: Enzyme, accessions: A8RR46, gene: bcl1, swissprot: A8RR46_BACCS) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: Q59401, gene: None, swissprot: Q59401_ENTCL) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: A1E3K9, gene: blaSCO-1, swissprot: A1E3K9_ECOLX) Beta-lactamase SHV-1 (Organism: Escherichia coli, class: Enzyme, accessions: P0AD63, gene: bla, swissprot: BLA1_ECOLX) Beta-lactamase (Organism: Bacillus licheniformis, class: Enzyme, accessions: P00808, gene: penP, swissprot: BLAC_BACLI) Class D beta-lactamase (Organism: Brachyspira pilosicoli, class: Unclassified, accessions: Q50H31, gene: oxa-63, swissprot: Q50H31_BRAPL) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Beta-lactamase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P00807, gene: blaZ, swissprot: BLAC_STAAU) | None | beta Lactamase Inhibitor (Code: N0000175930) beta Lactamase Inhibitors (Code: N0000000202) antiinfective agent (Code: CHEBI:35441) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) beta-Lactamase Inhibitors (Code: D065093) Enzyme Inhibitors (Code: D004791) | 1993-10-22 FDA | |
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| carbazochrome | a hemostatic which increases capillary resistance & activates platelet factors, Note: Adona is a multimeaning tradename | Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) | |
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| azapropazone | Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) uricosuric drug (Code: CHEBI:35841) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Peripheral Nervous System Agents (Code: D018373) Renal Agents (Code: D012076) Sensory System Agents (Code: D018689) Uricosuric Agents (Code: D014528) | 1972-01-01 YEAR INTRODUCED | |
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| testolactone | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) | An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer. | Aromatase Inhibitor (Code: N0000175563) Aromatase Inhibitors (Code: N0000175080) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) | 1969-06-03 FDA | |
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| alitretinoin | Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) Retinoic acid receptor RXR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P48443, gene: RXRG, swissprot: RXRG_HUMAN) Retinoic acid receptor RXR-beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P28702, gene: RXRB, swissprot: RXRB_HUMAN) Retinoic acid receptor RXR-alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P19793, gene: RXRA, swissprot: RXRA_HUMAN) Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) Nuclear receptor ROR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P51449, gene: RORC, swissprot: RORG_HUMAN) Retinoic acid receptor alpha (Organism: Mus musculus, class: Transcription factor, accessions: P11416, gene: Rara, swissprot: RARA_MOUSE) Retinoic acid receptor RXR-gamma (Organism: Mus musculus, class: Transcription factor, accessions: P28705, gene: Rxrg, swissprot: RXRG_MOUSE) Retinoic acid receptor RXR-beta (Organism: Mus musculus, class: Transcription factor, accessions: P28704, gene: Rxrb, swissprot: RXRB_MOUSE) Retinoic acid receptor gamma (Organism: Mus musculus, class: Transcription factor, accessions: P18911, gene: Rarg, swissprot: RARG_MOUSE) Retinoic acid receptor RXR-alpha (Organism: Mus musculus, class: Transcription factor, accessions: P28700, gene: Rxra, swissprot: RXRA_MOUSE) Retinoic acid receptor RXR-alpha (Organism: Rattus norvegicus, class: Unclassified, accessions: Q05343, gene: Rxra, swissprot: RXRA_RAT) Retinoic acid receptor beta (Organism: Mus musculus, class: Transcription factor, accessions: P22605, gene: Rarb, swissprot: RARB_MOUSE) | an RXR agonist | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) antineoplastic agent (Code: CHEBI:35610) keratolytic drug (Code: CHEBI:50176) Antineoplastic Agents (Code: D000970) | 1999-02-02 FDA | 1EPB 1FBY 1FM6 1FM9 1G5Y 1K74 1TYR 1XDK 1XIU 1XLS 2NNH 3DZU 3DZY 3E00 3LBD 3OAP 3UVV 4NQA 5JI0 5M24 5UAN |
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| norvinisterone | None | |
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| norgesterone | None | |
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| tretinoin | Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Retinoic acid receptor RXR-alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P19793, gene: RXRA, swissprot: RXRA_HUMAN) Retinoic acid receptor alpha (Organism: Mus musculus, class: Transcription factor, accessions: P11416, gene: Rara, swissprot: RARA_MOUSE) Retinoic acid receptor RXR-gamma (Organism: Mus musculus, class: Transcription factor, accessions: P28705, gene: Rxrg, swissprot: RXRG_MOUSE) Retinoic acid receptor RXR-beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P28702, gene: RXRB, swissprot: RXRB_HUMAN) Retinoic acid receptor RXR-beta (Organism: Mus musculus, class: Transcription factor, accessions: P28704, gene: Rxrb, swissprot: RXRB_MOUSE) Retinoic acid receptor gamma (Organism: Mus musculus, class: Transcription factor, accessions: P18911, gene: Rarg, swissprot: RARG_MOUSE) Retinoic acid receptor RXR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P48443, gene: RXRG, swissprot: RXRG_HUMAN) Cellular retinoic acid-binding protein 1 (Organism: Gallus gallus, class: Cytosolic other, accessions: P40220, gene: CRABP1, swissprot: RABP1_CHICK) Retinoic acid receptor RXR-alpha (Organism: Mus musculus, class: Transcription factor, accessions: P28700, gene: Rxra, swissprot: RXRA_MOUSE) Cellular retinoic acid-binding protein 1 (Organism: Mus musculus, class: Cytosolic other, accessions: P62965, gene: Crabp1, swissprot: RABP1_MOUSE) Retinoic acid receptor beta (Organism: Mus musculus, class: Transcription factor, accessions: P22605, gene: Rarb, swissprot: RARB_MOUSE) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Cellular retinoic acid-binding protein 2 (Organism: Mus musculus, class: Cytosolic other, accessions: P22935, gene: Crabp2, swissprot: RABP2_MOUSE) 11-cis retinol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: Q92781, gene: RDH5, swissprot: RDH1_HUMAN) Nuclear receptor ROR-beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92753, gene: RORB, swissprot: RORB_HUMAN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Nuclear receptor ROR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P51449, gene: RORC, swissprot: RORG_HUMAN) Nuclear receptor ROR-alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P35398, gene: RORA, swissprot: RORA_HUMAN) Nuclear receptor subfamily 2 group C member 2 (Organism: Homo sapiens, class: Unclassified, accessions: P49116, gene: NR2C2, swissprot: NR2C2_HUMAN) | An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) antineoplastic agent (Code: CHEBI:35610) keratolytic drug (Code: CHEBI:50176) anti-inflammatory agent (Code: CHEBI:67079) retinoic acid receptor agonist (Code: CHEBI:67198) Antineoplastic Agents (Code: D000970) Dermatologic Agents (Code: D003879) Keratolytic Agents (Code: D007641) | 1971-10-20 FDA | 1CBR 1CBS 1FEM 1GX9 1N4H 1RLB 2ACL 2FR3 2G78 2LBD 2VE3 3A9E 3CWK 3FAL 3FC6 4DM8 4TNS 5FHZ 5UAN 6EU9 |
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| metandienone | A synthetic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188) | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| isotretinoin | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Cellular retinoic acid-binding protein 1 (Organism: Gallus gallus, class: Cytosolic other, accessions: P40220, gene: CRABP1, swissprot: RABP1_CHICK) Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) 17-beta-hydroxysteroid dehydrogenase type 6 (Organism: Homo sapiens, class: Enzyme, accessions: O14756, gene: HSD17B6, swissprot: H17B6_HUMAN) 11-cis retinol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: Q92781, gene: RDH5, swissprot: RDH1_HUMAN) Dehydrogenase/reductase SDR family member 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BPW9, gene: DHRS9, swissprot: DHRS9_HUMAN) Alcohol dehydrogenase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P08319, gene: ADH4, swissprot: ADH4_HUMAN) Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) | A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects. | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) keratolytic drug (Code: CHEBI:50176) antineoplastic agent (Code: CHEBI:35610) Dermatologic Agents (Code: D003879) Noxae (Code: D009676) Teratogens (Code: D013723) | 1982-05-07 FDA | |
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| etynodiol | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1966-03-23 FDA | |
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| allylestrenol | A synthetic steroid with progestational activity. | Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) | |
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| temazepam | Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1981-02-27 FDA | |
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| clobazam | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | None | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) anticonvulsant (Code: CHEBI:35623) anxiolytic drug (Code: CHEBI:35474) GABA modulator (Code: CHEBI:50268) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 2011-10-21 FDA | |
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| etifoxine | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| clomacran | None | |
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| chlorcyclizine | Apoptosis regulator Bcl-2 (Organism: Homo sapiens, class: Cytosolic other, accessions: P10415, gene: BCL2, swissprot: BCL2_HUMAN) | None | None FDA | |
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| bromindione | None | |
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| isobromindione | None | |
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| oxymorphone | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Opioid receptors; mu and delta (Organism: Mus musculus, class: GPCR, accessions: P32300|P42866, gene: Oprd1|Oprm1, swissprot: OPRD_MOUSE|OPRM_MOUSE) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Delta-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P32300, gene: Oprd1, swissprot: OPRD_MOUSE) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) Kappa-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P34975, gene: Oprk1, swissprot: OPRK_RAT) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092) | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Adjuvants, Anesthesia (Code: D000759) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1959-04-02 FDA | |
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| spaglumic acid | Metabotropic glutamate receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: Q14832, gene: GRM3, swissprot: GRM3_HUMAN) | None | |
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| isoxsuprine | A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Sympathomimetics (Code: D013566) Tocolytic Agents (Code: D015149) Vasodilator Agents (Code: D014665) | None FDA | |
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| dobutamine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-1 Receptor Agonists (Code: D058665) Adrenergic beta-Agonists (Code: D000318) cardiotonic drug (Code: CHEBI:38147) sympathomimetic agent (Code: CHEBI:35524) beta-adrenergic agonist (Code: CHEBI:35522) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sympathomimetics (Code: D013566) | 1978-07-18 FDA | 2Y00 2Y01 |
|
|
| dihydrocodeine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | None | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1958-07-07 FDA | |
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| levdobutamine | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | |
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| tegaserod | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | a nonbenzamide 5-hydroxytryptamine(4) agonist; used in treatment of irritable bowel syndrome; marketing suspended 2007 in US due to higher incidence of MI, stroke, and unstable angina; structure given in first source | Serotonin 4 Receptor Antagonists (Code: N0000175816) Serotonin-4 Receptor Antagonist (Code: N0000175815) serotonergic agonist (Code: CHEBI:35941) gastrointestinal drug (Code: CHEBI:55324) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 2002-07-24 FDA | |
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| trihexyphenidyl | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic. | Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | 1949-05-13 FDA | |
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| bisulepine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | |
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| benoxaprofen | Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) non-narcotic analgesic (Code: CHEBI:35481) antipsoriatic (Code: CHEBI:50748) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Dermatologic Agents (Code: D003879) Enzyme Inhibitors (Code: D004791) Lipoxygenase Inhibitors (Code: D016859) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1982-04-19 FDA | |
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| eritrityl tetranitrate | A vasodilator with general properties similar to NITROGLYCERIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020) | vasodilator agent (Code: CHEBI:35620) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| quercetin | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Cyclin-dependent kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P06493, gene: CDK1, swissprot: CDK1_HUMAN) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) Lysine--tRNA ligase (Organism: Homo sapiens, class: Enzyme, accessions: Q15046, gene: KARS, swissprot: SYK_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) RAC-alpha serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31749, gene: AKT1, swissprot: AKT1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Cell division protein kinase 5 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q03114, gene: Cdk5, swissprot: CDK5_RAT) Urokinase-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00749, gene: PLAU, swissprot: UROK_HUMAN) Cationic trypsin (Organism: Bos taurus, class: Enzyme, accessions: P00760, gene: None, swissprot: TRY1_BOVIN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Aldose reductase (Organism: Sus scrofa, class: Enzyme, accessions: P80276, gene: AKR1B1, swissprot: ALDR_PIG) Amine oxidase [flavin-containing] A (Organism: Bos taurus, class: Enzyme, accessions: P21398, gene: MAOA, swissprot: AOFA_BOVIN) Phospholipase A2 (Organism: Homo sapiens, class: Enzyme, accessions: P04054, gene: PLA2G1B, swissprot: PA21B_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Alpha-amylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P04745, gene: AMY1A, swissprot: AMY1_HUMAN) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) NADPH oxidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: Q9NPH5, gene: NOX4, swissprot: NOX4_HUMAN) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Xanthine dehydrogenase/oxidase (Organism: Bos taurus, class: Enzyme, accessions: P80457, gene: XDH, swissprot: XDH_BOVIN) Cyclin-dependent kinase 5/CDK5 activator 1 (Organism: Homo sapiens, class: Kinase, accessions: Q00535|Q15078, gene: CDK5|CDK5R1, swissprot: CD5R1_HUMAN|CDK5_HUMAN) Chymotrypsin C (Organism: Homo sapiens, class: Enzyme, accessions: Q99895, gene: CTRC, swissprot: CTRC_HUMAN) Cyclin-dependent kinase 4/cyclin D1 (Organism: Homo sapiens, class: Kinase, accessions: P11802|P24385, gene: CCND1|CDK4, swissprot: CCND1_HUMAN|CDK4_HUMAN) Sorbitol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: Q00796, gene: SORD, swissprot: DHSO_HUMAN) Cyclin-dependent kinase 1/cyclin B1 (Organism: Homo sapiens, class: Kinase, accessions: P06493|P14635, gene: CCNB1|CDK1, swissprot: CCNB1_HUMAN|CDK1_HUMAN) Hypoxia-inducible factor 1-alpha inhibitor (Organism: Homo sapiens, class: Unclassified, accessions: Q9NWT6, gene: HIF1AN, swissprot: HIF1N_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Cyclin-dependent kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q00534, gene: CDK6, swissprot: CDK6_HUMAN) D-alanylalanine synthetase (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P07862, gene: ddlB, swissprot: DDLB_ECOLI) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit beta (Organism: Homo sapiens, class: Kinase, accessions: Q13554, gene: CAMK2B, swissprot: KCC2B_HUMAN) Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Sialidase (Organism: Clostridium perfringens, class: Enzyme, accessions: P10481, gene: nanH, swissprot: NANH_CLOPF) Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Phosphatidylinositol 3-kinase regulatory subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P27986, gene: PIK3R1, swissprot: P85A_HUMAN) Chymotrypsinogen B (Organism: Homo sapiens, class: Enzyme, accessions: P17538, gene: CTRB1, swissprot: CTRB1_HUMAN) Serine/threonine-protein kinase PLK1 (Organism: Homo sapiens, class: Kinase, accessions: P53350, gene: PLK1, swissprot: PLK1_HUMAN) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AEK4, gene: fabI, swissprot: FABI_ECOLI) Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Amine oxidase [flavin-containing] B (Organism: Bos taurus, class: Enzyme, accessions: P56560, gene: MAOB, swissprot: AOFB_BOVIN) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Replicase polyprotein 1ab (Organism: Human SARS coronavirus, class: Enzyme, accessions: P0C6X7, gene: rep, swissprot: R1AB_CVHSA) Prolyl endopeptidase (Organism: Homo sapiens, class: Enzyme, accessions: P48147, gene: PREP, swissprot: PPCE_HUMAN) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) Aldo-keto reductase family 1 member C21 (Organism: Mus musculus, class: Enzyme, accessions: Q91WR5, gene: Akr1c21, swissprot: AK1CL_MOUSE) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) Stromelysin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P08254, gene: MMP3, swissprot: MMP3_HUMAN) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Cytochrome P450 1B1 (Organism: Homo sapiens, class: Enzyme, accessions: Q16678, gene: CYP1B1, swissprot: CP1B1_HUMAN) Lymphocyte differentiation antigen CD38 (Organism: Homo sapiens, class: Enzyme, accessions: P28907, gene: CD38, swissprot: CD38_HUMAN) C-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P51679, gene: CCR4, swissprot: CCR4_HUMAN) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) Arachidonate 12-lipoxygenase, 12S-type (Organism: Homo sapiens, class: Enzyme, accessions: P18054, gene: ALOX12, swissprot: LOX12_HUMAN) Serine/threonine-protein kinase pim-1 (Organism: Homo sapiens, class: Kinase, accessions: P11309, gene: PIM1, swissprot: PIM1_HUMAN) Phosphodiesterase 2A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q01062, gene: Pde2a, swissprot: PDE2A_RAT) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Cytosol aminopeptidase (Organism: Sus scrofa, class: Unclassified, accessions: P28839, gene: LAP3, swissprot: AMPL_PIG) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) Estradiol 17-beta-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P37059, gene: HSD17B2, swissprot: DHB2_HUMAN) Arachidonate 15-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P16050, gene: ALOX15, swissprot: LOX15_HUMAN) C-X-C chemokine receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P25024, gene: CXCR1, swissprot: CXCR1_HUMAN) Alcohol dehydrogenase [NADP(+)] (Organism: Rattus norvegicus, class: Enzyme, accessions: P51635, gene: Akr1a1, swissprot: AK1A1_RAT) Cyclin-dependent kinase 1/cyclin B (Organism: Homo sapiens, class: Kinase, accessions: O95067|P06493|P14635|Q8WWL7, gene: CCNB1|CCNB2|CCNB3|CDK1, swissprot: CCNB1_HUMAN|CCNB2_HUMAN|CCNB3_HUMAN|CDK1_HUMAN) Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Arginase (Organism: Leishmania amazonensis, class: Enzyme, accessions: O96394, gene: None, swissprot: O96394_LEIAM) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) D-alanine--D-alanine ligase (Organism: Helicobacter pylori (strain HPAG1), class: Enzyme, accessions: Q1CTD3, gene: ddl, swissprot: DDL_HELPH) 5'-nucleotidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P21588, gene: Nt5e, swissprot: 5NTD_RAT) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) Alcohol dehydrogenase [NADP(+)] (Organism: Sus scrofa, class: Enzyme, accessions: P50578, gene: AKR1A1, swissprot: AK1A1_PIG) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Macrophage metalloelastase (Organism: Homo sapiens, class: Enzyme, accessions: P39900, gene: MMP12, swissprot: MMP12_HUMAN) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) Glutathione reductase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: P41921, gene: GLR1, swissprot: GSHR_YEAST) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Enoyl-acyl-carrier protein reductase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q965D5, gene: fabI, swissprot: Q965D5_PLAFA) 3-oxoacyl-acyl-carrier protein reductase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q965D6, gene: fabG, swissprot: Q965D6_PLAFA) Beta-hydroxyacyl-ACP dehydratase; Fatty acid synthesis protein (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q965D7, gene: fabZ, swissprot: Q965D7_PLAFA) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Serine/threonine-protein kinase Nek6 (Organism: Homo sapiens, class: Kinase, accessions: Q9HC98, gene: NEK6, swissprot: NEK6_HUMAN) Collagenase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P45452, gene: MMP13, swissprot: MMP13_HUMAN) Lactoylglutathione lyase (Organism: Homo sapiens, class: Enzyme, accessions: Q04760, gene: GLO1, swissprot: LGUL_HUMAN) Malate dehydrogenase (Organism: Thermus thermophilus, class: Enzyme, accessions: P10584, gene: mdh, swissprot: MDH_THETH) Serine/threonine-protein kinase Nek2 (Organism: Homo sapiens, class: Kinase, accessions: P51955, gene: NEK2, swissprot: NEK2_HUMAN) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) Nitric oxide synthase, inducible (Organism: Mus musculus, class: Enzyme, accessions: P29477, gene: Nos2, swissprot: NOS2_MOUSE) Glycogen synthase kinase-3 (Organism: Homo sapiens, class: Kinase, accessions: P49840|P49841, gene: GSK3A|GSK3B, swissprot: GSK3A_HUMAN|GSK3B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Organism: Homo sapiens, class: Kinase, accessions: P48736, gene: PIK3CG, swissprot: PK3CG_HUMAN) Glycogen phosphorylase, liver form (Organism: Homo sapiens, class: Enzyme, accessions: P06737, gene: PYGL, swissprot: PYGL_HUMAN) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) Death-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53355, gene: DAPK1, swissprot: DAPK1_HUMAN) | A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. | antineoplastic agent (Code: CHEBI:35610) Antioxidants (Code: D000975) Protective Agents (Code: D020011) | 1E8W 1GP6 1H1I 2C9Z 2HCK 2JJ2 2O3P 2UXH 3BPT 3BXX 3CF8 3LJ0 3LM5 3NVY 4DFU 4LMU 4MRA 4WNJ 5A4V 5AUW 5FLI 5FLJ 5XG4 |
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| olsalazine | Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Cyclooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P23219|P35354, gene: PTGS1|PTGS2, swissprot: PGH1_HUMAN|PGH2_HUMAN) | cpd with 2 salicylate molecules linked together by an azo bond | Aminosalicylate (Code: N0000175781) Aminosalicylic Acids (Code: N0000005760) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) prodrug (Code: CHEBI:50266) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1990-07-31 FDA | |
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| hesperetin | Cytochrome P450 1B1 (Organism: Homo sapiens, class: Enzyme, accessions: Q16678, gene: CYP1B1, swissprot: CP1B1_HUMAN) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) | aglycone of HESPERIDIN; structure | antineoplastic agent (Code: CHEBI:35610) | 5JDC |
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| terizidone | minor descriptor (1975-1984); on-line & Index Medicus search OXAZOLES (1975-1984); RN given refers to parent cpd without isomeric designation | |
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| florantyrone | None | |
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| masoprocol | Arachidonate 5-lipoxygenase (Organism: Mus musculus, class: Enzyme, accessions: P48999, gene: Alox5, swissprot: LOX5_MOUSE) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Seed linoleate 13S-lipoxygenase-1 (Organism: Glycine max, class: Enzyme, accessions: P08170, gene: LOX1.1, swissprot: LOX1_SOYBN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Arachidonate 15-lipoxygenase, type II (Organism: Homo sapiens, class: Enzyme, accessions: O15296, gene: ALOX15B, swissprot: LX15B_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) 5-lipoxygenase (Organism: Bos taurus, class: Enzyme, accessions: Q9BEG3, gene: None, swissprot: Q9BEG3_BOVIN) Arachidonate 12-lipoxygenase, 12S-type (Organism: Homo sapiens, class: Enzyme, accessions: P18054, gene: ALOX12, swissprot: LOX12_HUMAN) Arachidonate 15-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P16050, gene: ALOX15, swissprot: LOX15_HUMAN) Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) Leukotriene B4 receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q15722, gene: LTB4R, swissprot: LT4R1_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) Lipoxygenase (Organism: Glycine max, class: Unclassified, accessions: Q39829, gene: None, swissprot: Q39829_SOYBN) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) antineoplastic agent (Code: CHEBI:35610) hypoglycemic agent (Code: CHEBI:35526) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antioxidants (Code: D000975) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Lipoxygenase Inhibitors (Code: D016859) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sensory System Agents (Code: D018689) | 1992-09-04 FDA | |
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| aminopropylone | None | |
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| formestane | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) | None | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 1993-01-01 YEAR INTRODUCED | |
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| formylsulfamethin | None | |
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| epimestrol | A synthetic steroid with estrogenic activity. | Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| emedastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Inhibitor (Code: N0000175519) Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) antipruritic drug (Code: CHEBI:59683) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1997-12-29 FDA | |
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| neticonazole | None | |
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| oxendolone | None | |
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| methyltestosterone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL). | Androgen (Code: N0000175824) Androgen Receptor Agonists (Code: N0000000146) Androstanes (Code: N0000008241) Anabolic Agents (Code: D045930) antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1973-12-03 FDA | |
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| butamirate | None | |
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| eicosapentaenoic acid | Oxoeicosanoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS5, gene: OXER1, swissprot: OXER1_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Tissue factor (Organism: Homo sapiens, class: Membrane receptor, accessions: P13726, gene: F3, swissprot: TF_HUMAN) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. | None FDA | 1IGX 3GWX 3HS6 5M0O |
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| norethandrolone | A synthetic hormone with anabolic and androgenic properties and moderate progestational activity. | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| methenolone | A synthetic steroid that has been used for its anabolic action. | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| tricyclamol chloride | None | |
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| fludiazepam | None | Anti-Anxiety Agents (Code: D014151) anxiolytic drug (Code: CHEBI:35474) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| broxyquinoline | Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) | None | |
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| ethacrynic acid | Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Glutathione S-transferase P (Organism: Homo sapiens, class: Enzyme, accessions: P09211, gene: GSTP1, swissprot: GSTP1_HUMAN) UDP-glucose 4-epimerase (Organism: Homo sapiens, class: Enzyme, accessions: Q14376, gene: GALE, swissprot: GALE_HUMAN) Glutathione S-transferase A1 (Organism: Homo sapiens, class: Enzyme, accessions: P08263, gene: GSTA1, swissprot: GSTA1_HUMAN) | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. | Increased Diuresis at Loop of Henle (Code: N0000175366) loop diuretic (Code: CHEBI:77608) Diuretics (Code: D004232) Enzyme Inhibitors (Code: D004791) Natriuretic Agents (Code: D045283) | 1967-01-10 FDA | 11GS 1GSE 1GSF 2GSS 3DGQ 3GSS 3HJO 3KM6 3KMO 3N9J |
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| narcobarbital | None | |
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| Iofetamine (123I) | None | |
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| flumazenil | GABA A receptor alpha-6/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P30191|P63138, gene: Gabra6|Gabrb2|Gabrg2, swissprot: GBRA6_RAT|GBRB2_RAT|GBRG2_RAT) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor; anion channel (Organism: Bos taurus, class: Ion channel, accessions: P08219|P08220|P10063|P10064|P20237|P22300, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRB1|GABRG2, swissprot: GBRA1_BOVIN|GBRA2_BOVIN|GBRA3_BOVIN|GBRA4_BOVIN|GBRB1_BOVIN|GBRG2_BOVIN) Gamma-aminobutyric acid receptor subunit alpha-4 (Organism: Homo sapiens, class: Ion channel, accessions: P48169, gene: GABRA4, swissprot: GBRA4_HUMAN) GABA-A receptor; alpha-1/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P62813|P63138, gene: Gabra1|Gabrb2|Gabrg2, swissprot: GBRA1_RAT|GBRB2_RAT|GBRG2_RAT) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P20236|P63138, gene: Gabra3|Gabrb2|Gabrg2, swissprot: GBRA3_RAT|GBRB2_RAT|GBRG2_RAT) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-6/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|Q16445, gene: GABRA6|GABRB3|GABRG2, swissprot: GBRA6_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-5 (Organism: Homo sapiens, class: Ion channel, accessions: P31644, gene: GABRA5, swissprot: GBRA5_HUMAN) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P14867, gene: GABRA1, swissprot: GBRA1_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47869, gene: GABRA2, swissprot: GBRA2_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903, gene: GABRA3, swissprot: GBRA3_HUMAN) | A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses. | Benzodiazepine Antagonist (Code: N0000175680) GABA antagonist (Code: CHEBI:65259) antidote to benzodiazepine poisoning (Code: CHEBI:90757) Antidotes (Code: D000931) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1991-12-20 FDA | |
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| pipemidic acid | Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | |
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| scopolamine | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Muscarinic receptor M1 (Organism: Bos taurus, class: GPCR, accessions: Q8WMX0, gene: None, swissprot: Q8WMX0_BOVIN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic. | Anticholinergic (Code: N0000175574) Adjuvants, Anesthesia (Code: D000759) anaesthesia adjuvant (Code: CHEBI:60807) antispasmodic drug (Code: CHEBI:53784) mydriatic agent (Code: CHEBI:50513) adjuvant (Code: CHEBI:60809) antidepressant (Code: CHEBI:35469) antiemetic (Code: CHEBI:50919) muscarinic antagonist (Code: CHEBI:48876) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1979-12-31 FDA | |
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| fenoterol | Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) bronchodilator agent (Code: CHEBI:35523) sympathomimetic agent (Code: CHEBI:35524) beta-adrenergic agonist (Code: CHEBI:35522) tocolytic agent (Code: CHEBI:66993) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Tocolytic Agents (Code: D015149) | 1965-01-01 YEAR INTRODUCED | |
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| cocaine | Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Dopamine transporter (Organism: Bos taurus, class: Unclassified, accessions: P27922, gene: SLC6A3, swissprot: SC6A3_BOVIN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Dopamine transporter (Organism: Macaca fascicularis, class: Unclassified, accessions: Q9GJT6, gene: SLC6A3, swissprot: SC6A3_MACFA) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Cocaine- and amphetamine-regulated transcript protein (Organism: Homo sapiens, class: Transcription factor, accessions: Q16568, gene: CARTPT, swissprot: CART_HUMAN) Sodium- and chloride-dependent GABA transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P30531, gene: SLC6A1, swissprot: SC6A1_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Sodium channel protein type 11 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UI33, gene: SCN11A, swissprot: SCNBA_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Serotonin 3 receptor (5HT3) (Organism: Homo sapiens, class: Ion channel, accessions: O95264|P46098, gene: HTR3A|HTR3B, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) | An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) adrenergic uptake inhibitor (Code: CHEBI:35640) dopamine uptake inhibitor (Code: CHEBI:51039) serotonin uptake inhibitor (Code: CHEBI:50949) vasoconstrictor agent (Code: CHEBI:50514) local anaesthetic (Code: CHEBI:36333) central nervous system stimulant (Code: CHEBI:35337) sympathomimetic agent (Code: CHEBI:35524) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Vasoconstrictor Agents (Code: D014662) | 1860-01-01 YEAR INTRODUCED | 1I7Z 1Q72 2AJV 2PGZ 4XP4 4XPB |
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| vildagliptin | Prolyl endopeptidase FAP (Organism: Homo sapiens, class: Enzyme, accessions: Q12884, gene: FAP, swissprot: SEPR_HUMAN) Prolyl endopeptidase FAP (Organism: Mus musculus, class: Enzyme, accessions: P97321, gene: Fap, swissprot: SEPR_MOUSE) Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Dipeptidyl peptidase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q6V1X1, gene: DPP8, swissprot: DPP8_HUMAN) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) | a potent, selective and orally bio-available dipeptidyl-peptidase IV inhibitor | Dipeptidyl-Peptidase IV Inhibitors (Code: D054873) Enzyme Inhibitors (Code: D004791) Hypoglycemic Agents (Code: D007004) Protease Inhibitors (Code: D011480) | 2007-09-26 EMA | |
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| piroheptine | None | |
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| clofarabine | DNA polymerase alpha catalytic subunit (Organism: Homo sapiens, class: Enzyme, accessions: P09884, gene: POLA1, swissprot: DPOLA_HUMAN) Uridine-cytidine kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZX2, gene: UCK2, swissprot: UCK2_HUMAN) Uridine-cytidine kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9HA47, gene: UCK1, swissprot: UCK1_HUMAN) Ribose-phosphate pyrophosphokinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P60891, gene: PRPS1, swissprot: PRPS1_HUMAN) Ribonucleoside-diphosphate reductase subunit M2 (Organism: Homo sapiens, class: Enzyme, accessions: P31350, gene: RRM2, swissprot: RIR2_HUMAN) Ribonucleoside-diphosphate reductase large subunit (Organism: Homo sapiens, class: Enzyme, accessions: P23921, gene: RRM1, swissprot: RIR1_HUMAN) | Clofarabine is sequentially metabolized intracellularly to the 5'-monophosphate metabolite by deoxycytidine kinase and mono- and di-phospho-kinases to the active 5'-triphosphate metabolite. Clofarabine has affinity for the activating phosphorylating enzyme, deoxycytidine kinase, equal to or greater than that of the natural substrate, deoxycytidine. Clofarabine inhibits DNA synthesis by decreasing cellular deoxynucleotide triphosphate pools through an inhibitory action on ribonucleotide reductase, and by terminating DNA chain elongation and inhibiting repair through incorporation into the DNA chain by competitive inhibition of DNA polymerases. The affinity of clofarabine triphosphate for these enzymes is similar to or greater than that of deoxyadenosine triphosphate. In preclinical models, clofarabine has demonstrated the ability to inhibit DNA repair by incorporation into the DNA chain during the repair process. Clofarabine 5'-triphosphate also disrupts the integrity of mitochondrial membrane, leading to the release of the pro-apoptotic mitochondrial proteins, cytochrome C and apoptosis-inducing factor, leading to programmed cell death. Clofarabine is cytotoxic to rapidly proliferating and quiescent cancer cell types in vitro. | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | 2004-12-28 FDA | 2A7Q |
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| phenoxybenzamine | Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 1953-01-26 FDA | |
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| chlorphenoxamine | minor descriptor (66-84); on-line & Index Medicus search ETHYLAMINES (66-84); RN given refers to parent cpd | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | |
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| chlorambucil | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Cathepsin D (Organism: Homo sapiens, class: Enzyme, accessions: P07339, gene: CTSD, swissprot: CATD_HUMAN) Cathepsin E (Organism: Homo sapiens, class: Enzyme, accessions: P14091, gene: CTSE, swissprot: CATE_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Disintegrin and metalloproteinase domain-containing protein 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q13443, gene: ADAM9, swissprot: ADAM9_HUMAN) DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1957-03-18 FDA | 3CSJ |
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| flupirtine | Potassium voltage-gated channel subfamily KQT member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O43526, gene: KCNQ2, swissprot: KCNQ2_HUMAN) Potassium voltage-gated channel subfamily KQT member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O43525, gene: KCNQ3, swissprot: KCNQ3_HUMAN) | None | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1986-01-01 YEAR INTRODUCED | |
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| xyloylsulfamine | None | |
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| tilisolol | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| quinupramine | None | |
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| mesterolone | Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) | 17 beta-Hydroxy-1 alpha-methyl-5 alpha-androstan-3-one. A synthetic steroid with anabolic and androgenic activities. | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| mestanolone | Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | non-virilizing androgenic steroid; RN given refers to (5alpha,17beta)-isomer; structure | |
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| methandriol | A synthetic steroid with anabolic and androgenic properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1188) | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| cetylpyridinium | High affinity choline transporter 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BGY9, gene: Slc5a7, swissprot: SC5A7_MOUSE) Caspase-2 (Organism: Homo sapiens, class: Enzyme, accessions: P42575, gene: CASP2, swissprot: CASP2_HUMAN) | Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges. | antiseptic drug (Code: CHEBI:48218) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Detergents (Code: D003902) Surface-Active Agents (Code: D013501) | None FDA | |
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| clobuzarit | None | |
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| chlorfenethazine | None | |
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| acediasulfone | Dihydropteroate synthetase, putative (Organism: Plasmodium berghei (strain Anka), class: Unclassified, accessions: Q4Z710, gene: None, swissprot: Q4Z710_PLABA) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) | antibacterial drug for treatment of ear infections | |
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| dichlorphenamide | Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | antiglaucoma drug (Code: CHEBI:39456) ophthalmology drug (Code: CHEBI:66981) Carbonic Anhydrase Inhibitors (Code: D002257) Enzyme Inhibitors (Code: D004791) Carbonic Anhydrase Inhibitor (Code: N0000175517) Sulfonamides (Code: N0000008048) | 1958-07-22 FDA | 2POU |
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| delorazepam | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) | None | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | |
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| mannomustine | Nitrogen mustard derivative alkylating agent used as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| melphalan | L-type amino acid transporter 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63016, gene: Slc7a5, swissprot: LAT1_RAT) DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) drug allergen (Code: CHEBI:88188) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Myeloablative Agonists (Code: D019653) Noxae (Code: D009676) | 1964-01-17 FDA | |
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| vorinostat | Histone deacetylase (Organism: Zea mays, class: Enzyme, accessions: Q9ZTP8, gene: hd1b, swissprot: Q9ZTP8_MAIZE) Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Organism: Homo sapiens, class: Transcription factor, accessions: O15379|Q9Y618, gene: HDAC3|NCOR2, swissprot: HDAC3_HUMAN|NCOR2_HUMAN) Histone deacetylase-like amidohydrolase (Organism: Alcaligenes sp. (strain DSM 11172), class: Enzyme, accessions: Q70I53, gene: hdaH, swissprot: HDAH_ALCSD) Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) Histone deacetylase 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q96DB2, gene: HDAC11, swissprot: HDA11_HUMAN) Histone deacetylase (Organism: Homo sapiens, class: Enzyme, accessions: O15379|P56524|Q13547|Q8WUI4|Q92769|Q969S8|Q96DB2|Q9BY41|Q9UBN7|Q9UKV0|Q9UQL6, gene: HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9, swissprot: HDA10_HUMAN|HDA11_HUMAN|HDAC1_HUMAN|HDAC2_HUMAN|HDAC3_HUMAN|HDAC4_HUMAN|HDAC5_HUMAN|HDAC6_HUMAN|HDAC7_HUMAN|HDAC8_HUMAN|HDAC9_HUMAN) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) Histone deacetylase 1/3/5/8 (Organism: Homo sapiens, class: Enzyme, accessions: O15379|Q13547|Q9BY41|Q9UQL6, gene: HDAC1|HDAC3|HDAC5|HDAC8, swissprot: HDAC1_HUMAN|HDAC3_HUMAN|HDAC5_HUMAN|HDAC8_HUMAN) Histone deacetylase 3/NCoR1 (Organism: Homo sapiens, class: Transcription factor, accessions: O15379|O75376, gene: HDAC3|NCOR1, swissprot: HDAC3_HUMAN|NCOR1_HUMAN) Lysine-specific demethylase 4E (Organism: Homo sapiens, class: Enzyme, accessions: B2RXH2, gene: KDM4E, swissprot: KDM4E_HUMAN) Histone deacetylase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q7K6A1, gene: PfHDAC1, swissprot: Q7K6A1_PLAF7) Histone deacetylase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKV0, gene: HDAC9, swissprot: HDAC9_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P56524, gene: HDAC4, swissprot: HDAC4_HUMAN) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) Histone deacetylase 1 (Organism: Mus musculus, class: Enzyme, accessions: O09106, gene: Hdac1, swissprot: HDAC1_MOUSE) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) Histone deacetylase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q9XYC7, gene: HDAC1, swissprot: Q9XYC7_PLAFA) Histone deacetylase 5 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UQL6, gene: HDAC5, swissprot: HDAC5_HUMAN) Histone deacetylase (HDAC1 and HDAC2) (Organism: Homo sapiens, class: Enzyme, accessions: Q13547|Q92769, gene: HDAC1|HDAC2, swissprot: HDAC1_HUMAN|HDAC2_HUMAN) HD2 type histone deacetylase HDA106; Histone deacetylase 2b; Uncharacterized protein (Organism: Zea mays, class: Enzyme, accessions: Q94F81, gene: hda106, swissprot: Q94F81_MAIZE) Histone deacetylase (Organism: Rattus norvegicus, class: Enzyme, accessions: B1WBY8|Q4QQW4|Q5RJZ2|Q6P6W3|Q99P96|Q99P97|Q99P99, gene: Hdac1|Hdac2|Hdac3|Hdac4|Hdac5|Hdac6|Hdac7, swissprot: B1WBY8_RAT|HDAC1_RAT|HDAC3_RAT|HDAC4_RAT|HDAC7_RAT|Q5RJZ2_RAT|Q99P97_RAT) Histone deacetylase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q8WUI4, gene: HDAC7, swissprot: HDAC7_HUMAN) | inhibits histone deacetylase I & 3 | Histone Deacetylase Inhibitor (Code: N0000175588) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Histone Deacetylase Inhibitors (Code: D056572) antineoplastic agent (Code: CHEBI:35610) | 2006-10-06 FDA | 1C3S 1T69 1ZZ1 3C0Z 4BZ6 4LXZ 4QA0 4QA2 4R7L 5EEI |
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| entacapone | Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) | Entacapone is a selective and reversible inhibitor of COMT. COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated metabolites. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to greater effects on the signs and symptoms of Parkinson's disease. | Catechol-O-Methyltransferase Inhibitor (Code: N0000175757) central nervous system drug (Code: CHEBI:35470) antidyskinesia agent (Code: CHEBI:66956) antiparkinson drug (Code: CHEBI:48407) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Catechol O-Methyltransferase Inhibitors (Code: D065098) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) | 1999-10-19 FDA | |
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| zaleplon | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | an azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; a hypnotic with less marked effect on psychomotor functions compared to lorazepam | gamma-Aminobutyric Acid A Receptor Agonist (Code: N0000183360) GABA A Agonists (Code: N0000000196) Central Nervous System Depression (Code: N0000175728) anticonvulsant (Code: CHEBI:35623) central nervous system depressant (Code: CHEBI:35488) sedative (Code: CHEBI:35717) anxiolytic drug (Code: CHEBI:35474) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | 1999-08-13 FDA | |
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| cetraxate | broad spectrum peptide hydrolase inhibitor; RN given refers to (trans)-isomer; structure | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| bucumolol | None | |
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| atropine oxyde | None | |
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| capsaicin | Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Tyrosine--tRNA ligase, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P54577, gene: YARS, swissprot: SYYC_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Transient receptor potential cation channel subfamily V member 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: O35433, gene: Trpv1, swissprot: TRPV1_RAT) Transient receptor potential cation channel subfamily V member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NER1, gene: TRPV1, swissprot: TRPV1_HUMAN) NADH-ubiquinone oxidoreductase chain 1 (Organism: Bos taurus, class: Unclassified, accessions: P03887, gene: MT-ND1, swissprot: NU1M_BOVIN) Transient receptor potential cation channel subfamily M member 8 (Organism: Mus musculus, class: Unclassified, accessions: Q8R4D5, gene: Trpm8, swissprot: TRPM8_MOUSE) Potassium voltage-gated channel subfamily A member 1 (Organism: Mus musculus, class: Unclassified, accessions: P16388, gene: Kcna1, swissprot: KCNA1_MOUSE) Potassium voltage-gated channel subfamily A member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P63142, gene: Kcna2, swissprot: KCNA2_RAT) Potassium voltage-gated channel subfamily A member 7 (Organism: Mus musculus, class: Unclassified, accessions: Q17ST2, gene: Kcna7, swissprot: KCNA7_MOUSE) Transient receptor potential cation channel subfamily V member 1 (Organism: Mus musculus, class: Unclassified, accessions: Q704Y3, gene: Trpv1, swissprot: TRPV1_MOUSE) | An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS. | non-narcotic analgesic (Code: CHEBI:35481) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2009-11-16 FDA | |
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| roxatidine acetate | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) | a histamine H2 receptor antagonist drug used to treat gastric ulcers | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Neurotransmitter Agents (Code: D018377) | 1986-01-01 YEAR INTRODUCED | |
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| clioquinol | Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) Botulinum neurotoxin type A (Organism: Clostridium botulinum, class: Enzyme, accessions: P10845, gene: botA, swissprot: BXA1_CLOBO) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) | A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide. | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) antineoplastic agent (Code: CHEBI:35610) antiprotozoal drug (Code: CHEBI:35820) | None FDA | 3KCX |
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| nicofibrate | None | |
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| fenoldopam | D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Lysine-specific demethylase 4E (Organism: Homo sapiens, class: Enzyme, accessions: B2RXH2, gene: KDM4E, swissprot: KDM4E_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) Adenosine A2b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276, gene: Adora2b, swissprot: AA2BR_RAT) | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Dopaminergic Agonist (Code: N0000175580) dopaminergic antagonist (Code: CHEBI:48561) vasodilator agent (Code: CHEBI:35620) alpha-adrenergic agonist (Code: CHEBI:35569) dopamine agonist (Code: CHEBI:51065) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 1997-09-23 FDA | |
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| sertraline | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Transcriptional activator protein luxR (Organism: Aliivibrio fischeri, class: Unclassified, accessions: P12746, gene: luxR, swissprot: LUXR_ALIFS) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | A selective serotonin uptake inhibitor that is used in the treatment of depression. | Serotonin Reuptake Inhibitor (Code: N0000175696) serotonin uptake inhibitor (Code: CHEBI:50949) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 1991-12-30 FDA | 3GWU 4MM5 4MMB 6AWO 6AWQ 6F6N |
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| fluconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) 14-alpha sterol demethylase (Organism: Neosartorya fumigata, class: Enzyme, accessions: Q96W81, gene: cyp51B, swissprot: Q96W81_ASPFM) 14-alpha sterol demethylase Cyp51A (Organism: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100), class: Enzyme, accessions: Q4WNT5, gene: None, swissprot: Q4WNT5_ASPFU) Mycocyclosin synthase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP7, gene: cyp121, swissprot: CP121_MYCTU) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) | Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 CYP2C19 Inhibitors (Code: D065689) Cytochrome P-450 CYP2C9 Inhibitors (Code: D065688) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) | 1990-01-29 FDA | 4WMZ 1EA1 2IJ7 2WUZ 2WV2 2WX2 3KHM 3L4D 4ZDZ 4ZE3 5ESE 5ESF 5ESJ 5ESM 6AY4 |
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| phenolphthalol | None | |
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| propentofylline | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | None | Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | 3ARX 3AS2 |
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| amprotropine | None | |
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| oxandrolone | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | A synthetic hormone with anabolic and androgenic properties. | Anabolic Agents (Code: D045930) Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1964-07-21 FDA | |
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| butacaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | was MH 1965-92; BUTAPROBENZ & BUTOCAIN were see BUTACAINE 1978-92; use 4-AMINOBENZOIC ACID to search BUTACAINE 1966-92 | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| broxuridine | Thymidine kinase, cytosolic (Organism: Homo sapiens, class: Kinase, accessions: P04183, gene: TK1, swissprot: KITH_HUMAN) Thymidylate kinase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WKE1, gene: tmk, swissprot: KTHY_MYCTU) | A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. | antineoplastic agent (Code: CHEBI:35610) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) Noxae (Code: D009676) Radiation-Sensitizing Agents (Code: D011838) | 2GRB |
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| valethamate | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) | None | |
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| plaunotol | None | antineoplastic agent (Code: CHEBI:35610) anti-ulcer drug (Code: CHEBI:49201) nephroprotective agent (Code: CHEBI:76595) vulnerary (Code: CHEBI:73336) Anti-Infective Agents (Code: D000890) Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| epitiostanol | used in therapy of advanced breast cancer; structure | |
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| moxaverine | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| nitazoxanide | Pyruvate dehydrogenase [NADP(+)] (Organism: Cryptosporidium parvum, class: Enzyme, accessions: Q968X7, gene: PFOR, swissprot: PNO_CRYPV) Pyruvate:ferredoxin oxidoreductase (Organism: Giardia intestinalis, class: Enzyme, accessions: Q24982, gene: None, swissprot: Q24982_GIAIN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) | a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug; structure given in first source | Antiprotozoal (Code: N0000175485) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | 2002-11-22 FDA | 3V35 |
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| glutathione | Glutathione S-transferase kappa 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2Q3, gene: GSTK1, swissprot: GSTK1_HUMAN) | A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. | skin lightening agent (Code: CHEBI:85046) | |
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| carbocysteine-lysine | None | |
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| sulfasymazine | None | Anti-Infective Agents (Code: D000890) | |
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| ibopamine | None | Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Mydriatics (Code: D009184) Natriuretic Agents (Code: D045283) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | |
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| buflomedil | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | 1976-01-01 YEAR INTRODUCED | |
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| talastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | |
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| zolpidem | Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P23576, gene: Gabra2, swissprot: GBRA2_RAT) Gamma-aminobutyric acid receptor subunit alpha-5 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19969, gene: Gabra5, swissprot: GBRA5_RAT) GABA A receptor alpha-6/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P30191|P63138, gene: Gabra6|Gabrb2|Gabrg2, swissprot: GBRA6_RAT|GBRB2_RAT|GBRG2_RAT) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor; alpha-1/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P62813|P63138, gene: Gabra1|Gabrb2|Gabrg2, swissprot: GBRA1_RAT|GBRB2_RAT|GBRG2_RAT) Translocator protein (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P16257, gene: Tspo, swissprot: TSPO_RAT) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P23576|P63138, gene: Gabra2|Gabrb2|Gabrg2, swissprot: GBRA2_RAT|GBRB2_RAT|GBRG2_RAT) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P62813, gene: Gabra1, swissprot: GBRA1_RAT) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P18508|P20236|P63138, gene: Gabra3|Gabrb2|Gabrg2, swissprot: GBRA3_RAT|GBRB2_RAT|GBRG2_RAT) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P14867, gene: GABRA1, swissprot: GBRA1_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47869, gene: GABRA2, swissprot: GBRA2_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903, gene: GABRA3, swissprot: GBRA3_HUMAN) CAAX prenyl protease 2 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: Q03530, gene: RCE1, swissprot: RCE1_YEAST) | an azabicyclo(4.3.0)nonane; a nonbenzodiazepine; benzodiazepine receptor agonist; RN given from Toxline; RN not in Chemline 12/85; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; structure given in first source | gamma-Aminobutyric Acid-ergic Agonist (Code: N0000175759) GABA A Agonists (Code: N0000000196) Pyridines (Code: N0000007570) Central Nervous System Depression (Code: N0000175728) central nervous system depressant (Code: CHEBI:35488) GABA agonist (Code: CHEBI:51373) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Agonists (Code: D018755) GABA-A Receptor Agonists (Code: D058785) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) | 1992-12-16 FDA | |
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| tolnaftate | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) | A synthetic antifungal agent. | antifungal drug (Code: CHEBI:86327) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | None FDA | |
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| fabomotizole | None | |
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| betaxolol | Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A cardioselective beta-1-adrenergic antagonist with no partial agonist activity. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) sympatholytic agent (Code: CHEBI:66991) beta-adrenergic antagonist (Code: CHEBI:35530) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1985-08-30 FDA | |
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| benzatropine | Sodium-dependent neutral amino acid transporter B(0)AT1 (Organism: Homo sapiens, class: Unclassified, accessions: Q695T7, gene: SLC6A19, swissprot: S6A19_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. | Anticholinergic (Code: N0000175574) Antihistamine (Code: N0000175750) Histamine Receptor Antagonists (Code: N0000000207) antidyskinesia agent (Code: CHEBI:66956) muscarinic antagonist (Code: CHEBI:48876) antiparkinson drug (Code: CHEBI:48407) parasympatholytic (Code: CHEBI:50370) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | 1954-03-05 FDA | 6F6S |
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| mitobronitol | Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| mitolactol | Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| pirenoxine | developed for the therapy of human cataract; a structural analog of xanthomatine, a natural substance found in the eyes of some insects | |
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| sulisobenzone | None | None FDA | |
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| nimesulide | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Sodium-dependent neutral amino acid transporter B(0)AT1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q2A865, gene: Slc6a19, swissprot: S6A19_RAT) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1985-01-01 YEAR INTRODUCED | 1ZWP 2OTH 3E9X 3N8X 3QL6 4EIX |
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| warfarin | Vitamin K epoxide reductase complex subunit 1-like protein 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N0U8, gene: VKORC1L1, swissprot: VKORL_HUMAN) Vitamin K epoxide reductase complex subunit 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BQB6, gene: VKORC1, swissprot: VKOR1_HUMAN) Proprotein convertase subtilisin/kexin type 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q16549, gene: PCSK7, swissprot: PCSK7_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) | An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide. | Vitamin K Antagonist (Code: N0000175476) Vitamin K Inhibitors (Code: N0000175964) anticoagulant (Code: CHEBI:50249) rodenticide (Code: CHEBI:33288) Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) Pesticides (Code: D010575) Rodenticides (Code: D012378) | 1954-06-08 FDA | 1H9Z 1HA2 1OG5 2BXD |
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| roquinimex | None | Adjuvants, Immunologic (Code: D000276) Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) Immunologic Factors (Code: D007155) | |
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| nifenazone | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| ubenimex | Cytosol aminopeptidase (Organism: Homo sapiens, class: Enzyme, accessions: P28838, gene: LAP3, swissprot: AMPL_HUMAN) Aminopeptidase N (Organism: Mus musculus, class: Enzyme, accessions: P97449, gene: Anpep, swissprot: AMPN_MOUSE) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Aminopeptidase N (Organism: Rattus norvegicus, class: Unclassified, accessions: P15684, gene: Anpep, swissprot: AMPN_RAT) Bacterial leucyl aminopeptidase (Organism: Vibrio proteolyticus, class: Enzyme, accessions: Q01693, gene: None, swissprot: AMPX_VIBPR) Cytosol aminopeptidase (Organism: Bos taurus, class: Enzyme, accessions: P00727, gene: LAP3, swissprot: AMPL_BOVIN) Aminopeptidase B (Organism: Rattus norvegicus, class: Enzyme, accessions: O09175, gene: Rnpep, swissprot: AMPB_RAT) Leucyl-cystinyl aminopeptidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P97629, gene: Lnpep, swissprot: LCAP_RAT) Leukotriene A-4 hydrolase (Organism: Homo sapiens, class: Enzyme, accessions: P09960, gene: LTA4H, swissprot: LKHA4_HUMAN) Aminopeptidase B (Organism: Mus musculus, class: Enzyme, accessions: Q8VCT3, gene: Rnpep, swissprot: AMPB_MOUSE) Aminopeptidase N (Organism: Homo sapiens, class: Enzyme, accessions: P15144, gene: ANPEP, swissprot: AMPN_HUMAN) Aminopeptidase N (Organism: Sus scrofa, class: Enzyme, accessions: P15145, gene: ANPEP, swissprot: AMPN_PIG) M1 family aminopeptidase (Organism: Plasmodium falciparum (isolate FcB1 / Columbia), class: Enzyme, accessions: O96935, gene: None, swissprot: AMP1_PLAFQ) | growth inhibitor; RN given refers to ((L-Leu)-(S-(R*,S*)))-isomer; structure | Adjuvants, Immunologic (Code: D000276) Anti-Bacterial Agents (Code: D000900) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Protease Inhibitors (Code: D011480) | 1GW6 1HS6 1TXR 1XRY 2DQM 2EK9 2HPT 2XQ0 2YD0 2ZOF 2ZOG 3EBH 3FTX 3FUE 3FUF 3FUH 3H8G 3KR4 3MDJ 4FKK 4FYR 4GAA 4KXB 4RUH 4XMX 4ZLA 5IB9 5NTD |
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| phenylbutazone | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein (Organism: Canis familiaris, class: Enzyme, accessions: Q8SPQ9, gene: PTGS2, swissprot: Q8SPQ9_CANFA) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Prostacyclin synthase (Organism: Homo sapiens, class: Enzyme, accessions: Q16647, gene: PTGIS, swissprot: PTGIS_HUMAN) fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) | A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antirheumatic drug (Code: CHEBI:35842) peripheral nervous system drug (Code: CHEBI:49110) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1980-01-10 FDA | 2BXC 2BXP 2BXQ 2W98 |
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| gestrinone | Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) | A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) Reproductive Control Agents (Code: D012102) | |
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| metabutoxycaine | local anesthetic in operative dentistry | |
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| oxybuprocaine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) local anaesthetic (Code: CHEBI:36333) topical anaesthetic (Code: CHEBI:48425) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| indecainide | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | None | None FDA | |
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| pinazepam | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| alprazolam | Platelet-activating factor receptor (Organism: Homo sapiens, class: GPCR, accessions: P25105, gene: PTAFR, swissprot: PTAFR_HUMAN) Cholecystokinin receptor type A (Organism: Rattus norvegicus, class: GPCR, accessions: P30551, gene: Cckar, swissprot: CCKAR_RAT) Bromodomain-containing protein 4 (Organism: Homo sapiens, class: Unclassified, accessions: O60885, gene: BRD4, swissprot: BRD4_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) | A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238) | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) GABA agonist (Code: CHEBI:51373) anxiolytic drug (Code: CHEBI:35474) anticonvulsant (Code: CHEBI:35623) muscle relaxant (Code: CHEBI:51371) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1981-10-16 FDA | 3U5J |
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| aminaphthone | None | Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) | |
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| fluoxetine | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Mus musculus, class: Transporter, accessions: Q61327, gene: Slc6a3, swissprot: SC6A3_MOUSE) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Potassium voltage-gated channel subfamily C member 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: P25122, gene: Kcnc1, swissprot: KCNC1_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) Equilibrative nucleoside transporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q7RTT9, gene: SLC29A4, swissprot: S29A4_HUMAN) | The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. | Serotonin Reuptake Inhibitor (Code: N0000175696) drug allergen (Code: CHEBI:88188) serotonin uptake inhibitor (Code: CHEBI:50949) analgesic (Code: CHEBI:35480) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Cytochrome P-450 CYP2D6 Inhibitors (Code: D065690) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 1987-12-29 FDA | 3GWV 3GWW 4MM8 |
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| isomethadone | None | |
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| glymidine | was MH 1975-92 (see under SULFONAMIDES 1975-90); GLIDIAZINE & GLYCODIAZINE were see GLYMIDINE 1975-92; use SULFONAMIDES to search GLYMIDINE 1975-92; a sulfonamide hypoglycemic agent which stimulates insulin secretion | |
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| sulfaguanole | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| diacetazotol | None | |
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| nadolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) | A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for MIGRAINE DISORDERS and for tremor. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) antihypertensive agent (Code: CHEBI:35674) sympatholytic agent (Code: CHEBI:66991) beta-adrenergic antagonist (Code: CHEBI:35530) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1979-12-10 FDA | |
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| metipranolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) beta-adrenergic antagonist (Code: CHEBI:35530) anti-arrhythmia drug (Code: CHEBI:38070) antihypertensive agent (Code: CHEBI:35674) antiglaucoma drug (Code: CHEBI:39456) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1989-12-29 FDA | |
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| croconazole | None | |
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| dioxadrol | Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) | See also records for d- and l-forms which are referred to as dexoxadrol and levoxadrol, respectfully | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| amolanone | None | |
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| benzydamine | Soluble guanylate cyclase (Organism: Homo sapiens, class: Enzyme, accessions: O75343|P33402|Q02108|Q02153, gene: GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3, swissprot: GCYA2_HUMAN|GCYA3_HUMAN|GCYB1_HUMAN|GCYB2_HUMAN) | A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat. | Anti-Inflammatory Agents (Code: D000893) | |
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| ketotifen | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis. | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Inhibitor (Code: N0000175519) Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) anti-asthmatic drug (Code: CHEBI:49167) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1999-07-02 FDA | |
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| methadone | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Neuronal acetylcholine receptor subunit alpha-10 (Organism: Homo sapiens, class: Ion channel, accessions: Q9GZZ6, gene: CHRNA10, swissprot: ACH10_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) | A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3) | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | 1947-08-13 FDA | |
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| diphenidol | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | shows anti-arrhythmic activity; RN given refers to unlabeled parent cpd | Emesis Suppression (Code: N0000009034) antiemetic (Code: CHEBI:50919) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) | 1967-04-05 FDA | |
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| metixene | Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) | None | antiparkinson drug (Code: CHEBI:48407) muscarinic antagonist (Code: CHEBI:48876) histamine antagonist (Code: CHEBI:37956) | None FDA | |
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| dicycloverine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) SMR1-alpha2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P70676, gene: Vcsa2, swissprot: P70676_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) | A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. | Anticholinergic (Code: N0000175574) muscarinic antagonist (Code: CHEBI:48876) antispasmodic drug (Code: CHEBI:53784) parasympatholytic (Code: CHEBI:50370) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | 1950-05-11 FDA | |
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| chloralose | A derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most common use is as a general anesthetic in animal experiments. | Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| picrotin | Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Glycine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: O75311, gene: GLRA3, swissprot: GLRA3_HUMAN) Glycine receptor subunit beta (Organism: Homo sapiens, class: Ion channel, accessions: P48167, gene: GLRB, swissprot: GLRB_HUMAN) Glycine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P23416, gene: GLRA2, swissprot: GLRA2_HUMAN) | the less toxic component of picrotoxin lacking GABA activity | |
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| fotemustine | None | antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) | |
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| sulfadoxine | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase; Dihydropteroate synthetase (Organism: Plasmodium falciparum, class: Kinase, accessions: Q25704, gene: PPPK-DHPS, swissprot: Q25704_PLAFA) | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. | Sulfonamide (Code: N0000175880) Sulfonamides (Code: N0000008048) antibacterial drug (Code: CHEBI:36047) antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Renal Agents (Code: D012076) | 1981-10-28 FDA | |
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| sulfadimethoxine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) | A sulfanilamide that is used as an anti-infective agent. | antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) | |
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| trepibutone | None | |
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| cetamolol | None | |
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| bifonazole | Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | None | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 2BDM |
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| mestranol | Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES. | Estrogen (Code: N0000175825) Estrogen Receptor Agonists (Code: N0000000100) prodrug (Code: CHEBI:50266) xenoestrogen (Code: CHEBI:76988) Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1961-03-09 FDA | |
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| gestodene | Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | synthetic steroid with progestational activity; RN given refers to (17alpha)-isomer | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) Reproductive Control Agents (Code: D012102) | |
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| pecazine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | major descriptor (66-85); on-line search PHENOTHIAZINES (66-85); Index Medicus search MEPAZINE (66-85); RN given refers to parent cpd | |
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| desogestrel | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) | A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) contraceptive drug (Code: CHEBI:49323) synthetic oral contraceptive (Code: CHEBI:49326) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) Reproductive Control Agents (Code: D012102) | 1992-12-10 FDA | |
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| alloclamide | None | |
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| desloratadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | major metabolite of loratadine | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) cholinergic antagonist (Code: CHEBI:48873) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | 2001-12-21 FDA | |
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| nalorphine | Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Opioid receptor (Organism: Mus musculus, class: GPCR, accessions: O55242|P32300|P33534|P42866, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_MOUSE|OPRK_MOUSE|OPRM_MOUSE|SGMR1_MOUSE) | A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete. | Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| butofilolol | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | |
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| tolazamide | Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. | Sulfonylurea (Code: N0000175608) Sulfonylurea Compounds (Code: N0000008054) hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) | 1966-07-18 FDA | |
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| metahexamide | major descriptor (64-83); on-line search SULFONYLUREA COMPOUNDS (64-83); Index Medicus search METAHEXAMIDE (64-83); RN given refers to parent cpd; structure | |
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| fomocaine | a basic ether with local anesthetic action & relative low toxicity & systemic effects; minor descriptor (77-86); on-line & INDEX MEDICUS search PHENYL ETHERS (77-86); RN given refers to parent cpd | |
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| femoxetine | Sodium-dependent dopamine transporter (Organism: Mus musculus, class: Transporter, accessions: Q61327, gene: Slc6a3, swissprot: SC6A3_MOUSE) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | serotonin uptake inhibitor; RN given refers to (3R-trans)-isomer | Anti-Infective Agents (Code: D000890) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | |
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| dienogest | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | None | Progestin (Code: N0000175602) Progesterone Congeners (Code: N0000011301) synthetic oral contraceptive (Code: CHEBI:49326) progesterone receptor agonist (Code: CHEBI:70709) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptive Agents, Male (Code: D003272) Contraceptives, Oral (Code: D003276) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) | 2010-05-06 FDA | |
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| adiphenine | Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) | None | |
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| ambutonium | None | |
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| dimepheptanol | None | |
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| biperiden | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Anticholinergic (Code: N0000175574) antidote to sarin poisoning (Code: CHEBI:136860) antidyskinesia agent (Code: CHEBI:66956) muscarinic antagonist (Code: CHEBI:48876) parasympatholytic (Code: CHEBI:50370) antiparkinson drug (Code: CHEBI:48407) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | 1959-09-08 FDA | |
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| lodoxamide | G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) | None | Decreased Histamine Release (Code: N0000175628) Mast Cell Stabilizer (Code: N0000175630) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1993-09-23 FDA | |
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| pyrrobutamine | None | |
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| propamidine | Trypsin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P07477, gene: PRSS1, swissprot: TRY1_HUMAN) Acrosin (Organism: Sus scrofa, class: Unclassified, accessions: P08001, gene: ACR, swissprot: ACRO_PIG) | None | antiseptic drug (Code: CHEBI:48218) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | 102D 1PRP |
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| sulfaphenazole | Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | A sulfonilamide anti-infective agent. | antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) | 1974-04-02 FDA | |
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| artemotil | None | Amebicides (Code: D000563) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Antiprotozoal Agents (Code: D000981) Schistosomicides (Code: D012556) | |
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| ibuprofen guaiacol ester | None | |
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| oseltamivir | Neuraminidase (Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1), class: Enzyme, accessions: P03468, gene: NA, swissprot: NRAM_I34A1) Neuraminidase (Organism: Influenza B virus (strain B/Lee/1940), class: Enzyme, accessions: P03474, gene: NA, swissprot: NRAM_INBLE) Neuraminidase (Organism: Influenza A virus (A/duck/Laos/25/2006(H5N1)), class: Enzyme, accessions: C4LRQ6, gene: NA, swissprot: C4LRQ6_9INFA) Neuraminidase (Organism: Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)), class: Enzyme, accessions: Q2LFS1, gene: NA, swissprot: Q2LFS1_9INFA) Neuraminidase (Organism: Influenza A virus (A/Turkey/651242/2006(H5N1)), class: Enzyme, accessions: A5Z252, gene: NA, swissprot: A5Z252_9INFA) Neuraminidase (Organism: Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)), class: Enzyme, accessions: Q6Q793, gene: None, swissprot: Q6Q793_9INFA) Neuraminidase (Organism: Influenza A virus (strain A/Aichi/2/1968 H3N2), class: Enzyme, accessions: Q75VQ4, gene: NA, swissprot: NRAM_I68A0) Neuraminidase (Organism: Influenza A virus (A/RI/5+/1957(H2N2)), class: Enzyme, accessions: Q194T1, gene: None, swissprot: Q194T1_9INFA) Neuraminidase (Organism: Influenza A virus (strain A/Bangkok/1/1979 H3N2), class: Enzyme, accessions: P06818, gene: NA, swissprot: NRAM_I79A0) Neuraminidase (Organism: Influenza B virus (strain B/Victoria/3/1985), class: Enzyme, accessions: P16207, gene: NA, swissprot: NRAM_INBVI) Neuraminidase (Organism: Influenza A virus (strain A/USSR/90/1977 H1N1), class: Unclassified, accessions: P03469, gene: NA, swissprot: NRAM_I77AB) Neuraminidase (Organism: Influenza A virus (strain A/Wilson-Smith/1933 H1N1), class: Enzyme, accessions: P03470, gene: NA, swissprot: NRAM_I33A0) Neuraminidase (Organism: Influenza A virus (A/udorn/1972(H3N2)), class: Enzyme, accessions: Q20MD3, gene: NA, swissprot: Q20MD3_9INFA) | Oseltamivir phosphate is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate. Oseltamivir carboxylate is an inhibitor of influenza virus neuraminidase affecting release of viral particles. The median IC50 values of oseltamivir against influenza A/H1N1, influenza A/H3N2, and influenza B clinical isolates were 2.5 nM (range 0.93-4.16 nM, N=74), 0.96 nM (range 0.13 - 7.95 nM, N=774), and 60 nM (20-285 nM, N=256), respectively, in a neuraminidase assay with a fluorescently labeled MUNANA substrate. | Neuraminidase Inhibitor (Code: N0000175524) Neuraminidase Inhibitors (Code: N0000175436) prodrug (Code: CHEBI:50266) EC 3.2.1.18 (exo-alpha-sialidase) inhibitor (Code: CHEBI:52425) antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) | 1999-10-27 FDA | |
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| praziquantel | Glutathione S-transferase class-mu 26 kDa isozyme (Organism: Schistosoma japonicum, class: Enzyme, accessions: P08515, gene: None, swissprot: GST26_SCHJA) High voltage-activated calcium channel beta subunit CavB1 (Organism: Schistosoma mansoni, class: Ion channel, accessions: Q95US7, gene: None, swissprot: Q95US7_SCHMA) High voltage-activated calcium channel beta subunit CavB2 (Organism: Schistosoma mansoni, class: Ion channel, accessions: Q962H3, gene: None, swissprot: Q962H3_SCHMA) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) | An anthelmintic used in most schistosome and many cestode infestations. | Antihelminthic (Code: N0000175481) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | 1982-12-29 FDA | 1GTB |
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| granisetron | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P32297, gene: CHRNA3, swissprot: ACHA3_HUMAN) 5-hydroxytryptamine receptor 3B (Organism: Homo sapiens, class: Ion channel, accessions: O95264, gene: HTR3B, swissprot: 5HT3B_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients. | Serotonin 3 Receptor Antagonists (Code: N0000175817) Serotonin-3 Receptor Antagonist (Code: N0000175818) serotonergic antagonist (Code: CHEBI:48279) antiemetic (Code: CHEBI:50919) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1993-12-29 FDA | 2YME |
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| glybuthiazol | None | |
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| olanzapine | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug's efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. The mechanism of action of olanzapine in the treatment of acute manic or mixed episodes associated with bipolar I disorder is unknown. | Atypical Antipsychotic (Code: N0000175430) histamine antagonist (Code: CHEBI:37956) muscarinic antagonist (Code: CHEBI:48876) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) antiemetic (Code: CHEBI:50919) serotonin uptake inhibitor (Code: CHEBI:50949) second generation antipsychotic (Code: CHEBI:65191) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Gastrointestinal Agents (Code: D005765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) Tranquilizing Agents (Code: D014149) | 1996-09-30 FDA | |
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| tibolone | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Steryl-sulfatase (Organism: Homo sapiens, class: Enzyme, accessions: P08842, gene: STS, swissprot: STS_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | used in prevention of postmenopausal osteoporosis | Anabolic Agents (Code: D045930) Androgen Antagonists (Code: D000726) bone density conservation agent (Code: CHEBI:50646) hormone agonist (Code: CHEBI:51060) Antihypertensive Agents (Code: D000959) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Cardiovascular Agents (Code: D002317) Estrogen Receptor Modulators (Code: D020847) Hormone Antagonists (Code: D006727) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1988-01-01 YEAR INTRODUCED | |
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| levonorgestrel | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. | Progestin (Code: N0000175602) Inhibit Ovum Fertilization (Code: N0000175830) Progesterone Congeners (Code: N0000011301) Progestin-containing Intrauterine Device (Code: N0000175832) contraceptive drug (Code: CHEBI:49323) synthetic oral contraceptive (Code: CHEBI:49326) female contraceptive drug (Code: CHEBI:49324) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1968-04-16 FDA | 1LHV 3D90 |
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| ethisterone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) | 17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects. | |
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| dydrogesterone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Nuclear receptor subfamily 2 group E member 1 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q9Y466, gene: NR2E1, swissprot: NR2E1_HUMAN) | A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION. | Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) | None FDA | |
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| demegestone | a norprogesterone derivative that acts like PROGESTERONE in increasing SEX HORMONE-BINDING GLOBULIN; structure | |
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| profenamine | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) muscarinic antagonist (Code: CHEBI:48876) antiparkinson drug (Code: CHEBI:48407) histamine antagonist (Code: CHEBI:37956) adrenergic antagonist (Code: CHEBI:37887) antidyskinesia agent (Code: CHEBI:66956) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | None FDA | 6EQP |
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| lonazolac | Prostaglandin E synthase (Organism: Homo sapiens, class: Enzyme, accessions: O14684, gene: PTGES, swissprot: PTGES_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antineoplastic agent (Code: CHEBI:35610) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| brompheniramine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1957-08-23 FDA | |
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| flunitrazepam | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903|P47870|Q99928, gene: GABRA3|GABRB2|GABRG3, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P47870|Q99928, gene: GABRA1|GABRB2|GABRG3, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P31644|P47870|Q99928, gene: GABRA5|GABRB2|GABRG3, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-3/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472|P31644|Q99928, gene: GABRA5|GABRB3|GABRG3, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG3_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903, gene: GABRA3, swissprot: GBRA3_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-5 (Organism: Homo sapiens, class: Ion channel, accessions: P31644, gene: GABRA5, swissprot: GBRA5_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P14867, gene: GABRA1, swissprot: GBRA1_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47869, gene: GABRA2, swissprot: GBRA2_HUMAN) | A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1976-01-01 YEAR INTRODUCED | |
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| flubendazole | the p-fluoro analog of mebendazole | Anthelmintics (Code: D000871) antinematodal drug (Code: CHEBI:35444) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) | |
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| benorilate | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| ethylmorphine | A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function. | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | |
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| xenysalate | None | |
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| reboxetine | Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Kir3.1/Kir3.2 (Organism: Homo sapiens, class: Ion channel, accessions: P48051|P48549, gene: KCNJ3|KCNJ6, swissprot: KCNJ3_HUMAN|KCNJ6_HUMAN) Kir3.1/Kir3.4 (Organism: Homo sapiens, class: Ion channel, accessions: P48544|P48549, gene: KCNJ3|KCNJ5, swissprot: KCNJ3_HUMAN|KCNJ5_HUMAN) G protein-activated inward rectifier potassium channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: P48051, gene: KCNJ6, swissprot: KCNJ6_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | 1997-01-01 YEAR INTRODUCED | 4XNX |
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| arbutamine | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) beta-adrenergic agonist (Code: CHEBI:35522) cardiotonic drug (Code: CHEBI:38147) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | 1997-09-12 FDA | |
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| oxyfedrine | A drug used in the treatment of angina pectoris, heart failure, conduction defects, and myocardial infarction. It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | |
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| indisetron | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | an anti-emetic agent, indisetron hydrochloride was developed in Japan | |
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| fenalcomine | None | |
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| chlorozotocin | 2-chloroethyl analog of streptozotocin with superior activity against leukemia L1210 and reduced bone marrow toxicity; RN given refers to (D)-isomer; structure | Antineoplastic Agents (Code: D000970) Carcinogens (Code: D002273) Noxae (Code: D009676) | |
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| amoxapine | 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Sodium- and chloride-dependent glycine transporter 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y345, gene: SLC6A5, swissprot: SC6A5_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both. It also blocks dopamine receptors. | Tricyclic Antidepressant (Code: N0000175752) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) antidepressant (Code: CHEBI:35469) adrenergic uptake inhibitor (Code: CHEBI:35640) dopaminergic antagonist (Code: CHEBI:48561) serotonin uptake inhibitor (Code: CHEBI:50949) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 1980-09-22 FDA | |
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| dantrolene | Ryanodine receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P21817, gene: RYR1, swissprot: RYR1_HUMAN) Ryanodine receptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q15413, gene: RYR3, swissprot: RYR3_HUMAN) | Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants. | Decreased Striated Muscle Contraction (Code: N0000008953) Decreased Striated Muscle Tone (Code: N0000175735) Skeletal Muscle Relaxant (Code: N0000175738) muscle relaxant (Code: CHEBI:51371) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | 1974-01-15 FDA | |
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| pimefylline | None | |
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| rofecoxib | Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Bos taurus, class: Enzyme, accessions: O62698, gene: PTGS2, swissprot: PGH2_BOVIN) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) Prostaglandin G/H synthase 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355, gene: Ptgs2, swissprot: PGH2_RAT) Prostaglandin G/H synthase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63921, gene: Ptgs1, swissprot: PGH1_RAT) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | a sulfonylphenyl furanone; withdrawn out of concern for TOXICITY | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) analgesic (Code: CHEBI:35480) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1999-05-20 FDA | 5KIR |
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| valdecoxib | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Cytochrome c oxidase subunit 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00403, gene: MT-CO2, swissprot: COX2_HUMAN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Cytochrome c oxidase subunit 1 (Organism: Ovis aries, class: Unclassified, accessions: O78749, gene: MT-CO1, swissprot: COX1_SHEEP) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | a COX-2 inhibitor | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2001-11-16 FDA | 2AW1 |
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| ranitidine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Histamine H2 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P47747, gene: HRH2, swissprot: HRH2_CAVPO) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Histamine H2 receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P25102, gene: Hrh2, swissprot: HRH2_RAT) | A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. | Histamine H2 Receptor Antagonists (Code: N0000000151) Histamine-2 Receptor Antagonist (Code: N0000175784) H2-receptor antagonist (Code: CHEBI:37961) anti-ulcer drug (Code: CHEBI:49201) drug allergen (Code: CHEBI:88188) Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Neurotransmitter Agents (Code: D018377) | 1977-08-29 FDA | |
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| methopromazine | None | |
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| dronabinol | Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) G-protein coupled receptor 55 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y2T6, gene: GPR55, swissprot: GPR55_HUMAN) Cannabinoid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P34972, gene: CNR2, swissprot: CNR2_HUMAN) Cannabinoid receptor (Organism: Homo sapiens, class: GPCR, accessions: P21554|P34972, gene: CNR1|CNR2, swissprot: CNR1_HUMAN|CNR2_HUMAN) N-arachidonyl glycine receptor (Organism: Homo sapiens, class: GPCR, accessions: Q14330, gene: GPR18, swissprot: GPR18_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Cannabinoid receptor 1 (Organism: Mus musculus, class: GPCR, accessions: P47746, gene: Cnr1, swissprot: CNR1_MOUSE) Cannabinoid receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: P20272, gene: Cnr1, swissprot: CNR1_RAT) Cannabinoid receptor 2 (Organism: Mus musculus, class: GPCR, accessions: P47936, gene: Cnr2, swissprot: CNR2_MOUSE) Cannabinoid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P20272|Q9QZN9, gene: Cnr1|Cnr2, swissprot: CNR1_RAT|CNR2_RAT) Glycine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P23416, gene: GLRA2, swissprot: GLRA2_HUMAN) Glycine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: O75311, gene: GLRA3, swissprot: GLRA3_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Transient receptor potential cation channel subfamily V member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q9WUD2, gene: Trpv2, swissprot: TRPV2_RAT) | A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. | Cannabinoid (Code: N0000175782) Cannabinoids (Code: N0000008010) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-narcotic analgesic (Code: CHEBI:35481) hallucinogen (Code: CHEBI:35499) Cannabinoid Receptor Agonists (Code: D063386) Cannabinoid Receptor Modulators (Code: D063385) Central Nervous System Agents (Code: D002491) Hallucinogens (Code: D006213) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) | 1985-05-31 FDA | 3LS4 |
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| progesterone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Oryctolagus cuniculus, class: Transcription factor, accessions: P06186, gene: PGR, swissprot: PRGR_RABIT) Sterol O-acyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P35610, gene: SOAT1, swissprot: SOAT1_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Androgen receptor (Organism: Mus musculus, class: Transcription factor, accessions: P19091, gene: Ar, swissprot: ANDR_MOUSE) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211|Q62986, gene: Esr1|Esr2, swissprot: ESR1_RAT|ESR2_RAT) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Fatty acid-binding protein, intestinal (Organism: Homo sapiens, class: Cytosolic other, accessions: P12104, gene: FABP2, swissprot: FABPI_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) Steroid 5-alpha-reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P24008|P31214, gene: Srd5a1|Srd5a2, swissprot: S5A1_RAT|S5A2_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Short transient receptor potential channel 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UL62, gene: TRPC5, swissprot: TRPC5_HUMAN) Cation channel sperm-associated protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NEC5, gene: CATSPER1, swissprot: CTSR1_HUMAN) Cation channel sperm-associated protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q7RTX7, gene: CATSPER4, swissprot: CTSR4_HUMAN) Cation channel sperm-associated protein 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q96P56, gene: CATSPER2, swissprot: CTSR2_HUMAN) Cation channel sperm-associated protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q86XQ3, gene: CATSPER3, swissprot: CTSR3_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS. | Progesterone (Code: N0000005934) contraceptive drug (Code: CHEBI:49323) progesterone receptor agonist (Code: CHEBI:70709) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) | 1976-02-04 FDA | 1A28 1DBB 1H60 1MRQ 1W0F 1YA3 2AA5 2AA6 2ABA 2HZQ 2O5Y 3COT 4BB2 4FN9 4J6C 4L1W 4L1X 4LTW 4NKX 4R21 4Y8W 5A1P 5A1R 5LUR 6F88 6F8C |
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| sulbentine | Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) | None | |
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| pergolide | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Cerebral cortex alpha adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130|Q28838, gene: ADRA1A|ADRA2A, swissprot: ADA1A_BOVIN|ADA2A_BOVIN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) | A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES. | Ergot Alkaloids (Code: N0000007620) Ergot-derived Dopamine Receptor Agonist (Code: N0000175767) antiparkinson drug (Code: CHEBI:48407) dopamine agonist (Code: CHEBI:51065) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | 1988-12-30 FDA | |
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| clorazepate | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) prodrug (Code: CHEBI:50266) anticonvulsant (Code: CHEBI:35623) anxiolytic drug (Code: CHEBI:35474) GABA modulator (Code: CHEBI:50268) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1972-06-23 FDA | |
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| clobenzepam | None | |
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| homochlorcyclizine | None | |
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| clomipramine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Sodium-dependent serotonin transporter (Organism: Mus musculus, class: Transporter, accessions: Q60857, gene: Slc6a4, swissprot: SC6A4_MOUSE) Glutathione S-transferase P (Organism: Homo sapiens, class: Enzyme, accessions: P09211, gene: GSTP1, swissprot: GSTP1_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Trypanothione reductase (Organism: Trypanosoma brucei brucei, class: Unclassified, accessions: P39051, gene: TPR, swissprot: TYTR_TRYBB) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) | A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine. | Tricyclic Antidepressant (Code: N0000175752) serotonin uptake inhibitor (Code: CHEBI:50949) antidepressant (Code: CHEBI:35469) serotonergic antagonist (Code: CHEBI:48279) serotonergic drug (Code: CHEBI:48278) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 1989-12-29 FDA | 2Q6H 2QEI 4MMA |
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| loflucarban | None | |
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| oxycodone | Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) Kappa-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P34975, gene: Oprk1, swissprot: OPRK_RAT) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | A semisynthetic derivative of CODEINE. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) antitussive (Code: CHEBI:51177) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1950-04-12 FDA | |
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| alizapride | D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) | 1981-01-01 YEAR INTRODUCED | |
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| protizinic acid | None | |
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| mitiglinide | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | a rapid and short-acting hypoglycemic agent; acts on sulfonylurea receptor closing KATP channels; considered one of the glinides-an imprecise grouping; structure given in first source | Hypoglycemic Agents (Code: D007004) | 2011-04-22 PMDA | |
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| saxagliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Dipeptidyl peptidase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q6V1X1, gene: DPP8, swissprot: DPP8_HUMAN) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) | inhibits Dipeptidyl Peptidase-4 | hypoglycemic agent (Code: CHEBI:35526) Dipeptidyl-Peptidase IV Inhibitors (Code: D054873) Enzyme Inhibitors (Code: D004791) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Hypoglycemic Agents (Code: D007004) Incretins (Code: D054795) Protease Inhibitors (Code: D011480) | 2009-07-31 FDA | |
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| fendiline | Extracellular calcium-sensing receptor (Organism: Homo sapiens, class: GPCR, accessions: P41180, gene: CASR, swissprot: CASR_HUMAN) Transcriptional activator protein luxR (Organism: Aliivibrio fischeri, class: Unclassified, accessions: P12746, gene: luxR, swissprot: LUXR_ALIFS) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Extracellular calcium-sensing receptor (Organism: Bos taurus, class: GPCR, accessions: P35384, gene: CASR, swissprot: CASR_BOVIN) | Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents. | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| pamaquine | None | |
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| rotigotine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) | Rotigotine is a non-ergoline dopamine agonist. The precise mechanism of action of rotigotine as a treatment for Parkinson's disease is unknown, although it is thought to be related to its ability to stimulate dopamine receptors within the caudate-putamen in the brain. The precise mechanism of action of rotigotine as a treatment for Restless Legs Syndrome is unknown but is thought to be related to its ability to stimulate dopamine receptors. | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | 2007-05-09 FDA | |
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| triclocarban | Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) Epoxide hydrolase; Epoxide hydrolase EphB (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P95276, gene: None, swissprot: P95276_MYCTO) Epoxide hydrolase 1 (Organism: Homo sapiens, class: Unclassified, accessions: P07099, gene: EPHX1, swissprot: HYEP_HUMAN) Epoxide hydrolase 1 (Organism: Mus musculus, class: Unclassified, accessions: Q9D379, gene: Ephx1, swissprot: HYEP_MOUSE) | bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure | antiseptic drug (Code: CHEBI:48218) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Environmental Pollutants (Code: D004785) Water Pollutants, Chemical (Code: D014874) | None FDA | |
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| efavirenz | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Reverse transcriptase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9WKE8, gene: reverse transcriptas, swissprot: Q9WKE8_9HIV1) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) | Efavirenz is a non-nucleoside reverse transcriptase (RT) inhibitor of HIV-1. Efavirenz activity is mediated predominantly by noncompetitive inhibition of HIV-1 reverse transcriptase. HIV-2 RT and human cellular DNA polymerases alpha, beta, gamma, and delta are not inhibited by efavirenz. | Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175463) Non-Nucleoside Analog (Code: N0000175460) Non-Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009948) Cytochrome P450 3A Inducers (Code: N0000190118) Cytochrome P450 2B6 Inducers (Code: N0000187064) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Cytochrome P-450 CYP2B6 Inducers (Code: D065695) Cytochrome P-450 CYP2C19 Inhibitors (Code: D065689) Cytochrome P-450 CYP2C9 Inhibitors (Code: D065688) Cytochrome P-450 CYP3A Inducers (Code: D065701) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 1998-09-17 FDA | 1FK9 1FKO 1IKV 1IKW 1JKH 4B3O 6BSG 6BSH 6BSI 6BSJ |
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| clonazepam | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor; anion channel (Organism: Bos taurus, class: Ion channel, accessions: P08219|P08220|P10063|P10064|P20237|P22300, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRB1|GABRG2, swissprot: GBRA1_BOVIN|GBRA2_BOVIN|GBRA3_BOVIN|GBRA4_BOVIN|GBRB1_BOVIN|GBRG2_BOVIN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) | An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) anticonvulsant (Code: CHEBI:35623) GABA modulator (Code: CHEBI:50268) anxiolytic drug (Code: CHEBI:35474) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) | 1975-06-04 FDA | |
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| fentiazac | Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| chlorprothixene | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | A thioxanthine with effects similar to the phenothiazine antipsychotics. | non-narcotic analgesic (Code: CHEBI:35481) antiemetic (Code: CHEBI:50919) sedative (Code: CHEBI:35717) cholinergic antagonist (Code: CHEBI:48873) dopaminergic antagonist (Code: CHEBI:48561) first generation antipsychotic (Code: CHEBI:65190) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1967-06-19 FDA | |
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| pentaerithrityl tetranitrate | A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025) | vasodilator agent (Code: CHEBI:35620) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| bromazepam | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS. | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1974-01-01 YEAR INTRODUCED | |
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| febuxostat | Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) Xanthine dehydrogenase/oxidase (Organism: Bos taurus, class: Enzyme, accessions: P80457, gene: XDH, swissprot: XDH_BOVIN) Xanthine dehydrogenase/oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22985, gene: Xdh, swissprot: XDH_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT. | Xanthine Oxidase Inhibitor (Code: N0000175698) Xanthine Oxidase Inhibitors (Code: N0000000206) Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) | 2015-02-26 EMA 2009-02-13 FDA | 1N5X |
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| tinoridine | Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) | proposed anti-inflammatory agent; minor descriptor (75-86); on-line & INDEX MEDICUS seach PYRIDINES (75-86) | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| timolol | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) antihypertensive agent (Code: CHEBI:35674) anti-arrhythmia drug (Code: CHEBI:38070) beta-adrenergic antagonist (Code: CHEBI:35530) antiglaucoma drug (Code: CHEBI:39456) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1978-08-17 FDA | 3D4S |
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| butalamine | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| pregnenolone succinate | Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. | |
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| calusterone | was MH 1975-92 (see under METHYLTESTOSTERONE 1975-90); use METHYLTESTOSTERONE to search CALUSTERONE 1975-92 | |
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| nilutamide | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | Nilutamide ia a nonsteroidal, orally active antiandrogen. Nilutamide has demonstrated antiandrogenic activity without other hormonal (estrogen, progesterone, mineralocorticoid, and glucocorticoid) effects. In vitro, nilutamide blocks the effects of testosterone at the androgen receptor level. In vivo, nilutamide interacts with the androgen receptor and prevents the normal androgenic response. | Androgen Receptor Antagonists (Code: N0000000243) Androgen Receptor Inhibitor (Code: N0000175560) Androgen Antagonists (Code: D000726) antineoplastic agent (Code: CHEBI:35610) androgen antagonist (Code: CHEBI:35497) Antineoplastic Agents (Code: D000970) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1996-09-19 FDA | |
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| zimeldine | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385) | Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | |
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| oxyphenisatine | None | None FDA | |
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| denopamine | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) | |
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| tetrabenazine | Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Synaptic vesicular amine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q01827, gene: Slc18a2, swissprot: VMAT2_RAT) Synaptic vesicular amine transporter (Organism: Bos taurus, class: Transporter, accessions: Q27963, gene: SLC18A2, swissprot: VMAT2_BOVIN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Chromaffin granule amine transporter (Organism: Homo sapiens, class: Transporter, accessions: P54219, gene: SLC18A1, swissprot: VMAT1_HUMAN) | A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system. | Vesicular Monoamine Transporter 2 Inhibitor (Code: N0000190856) Vesicular Monoamine Transporter 2 Inhibitors (Code: N0000190855) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) antipsychotic agent (Code: CHEBI:35476) adrenergic uptake inhibitor (Code: CHEBI:35640) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 2008-08-15 FDA | |
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| nateglinide | Solute carrier family 22 member 6 (Organism: Rattus norvegicus, class: Transporter, accessions: O35956, gene: Slc22a6, swissprot: S22A6_RAT) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | considered one of the glinides, an imprecise grouping; ; RN refers to (trans,D-Phe)-isomer | Glinide (Code: N0000175428) Potassium Channel Antagonists (Code: N0000175448) hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) | 2000-12-22 FDA | |
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| docosanol | Envelope glycoprotein (Organism: Human herpesvirus 1 (strain 17), class: Membrane other, accessions: O09800|P04288|P04488|P06477|P06480|P06484|P06487|P10185|P10211|P10228|P68331|Q69091, gene: gB|gC|gD|gE|gG|gH|gI|gJ|gK|gL|gM|gN, swissprot: GB_HHV11|GC_HHV11|GD_HHV11|GE_HHV11|GG_HHV11|GH_HHV11|GI_HHV11|GJ_HHV11|GK_HHV11|GL_HHV11|GM_HHV11|GN_HHV11) | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 2000-07-25 FDA | |
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| butenafine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), class: Enzyme, accessions: Q5NGQ3, gene: fabI, swissprot: Q5NGQ3_FRATT) Squalene epoxidase (Organism: Trichophyton rubrum, class: Enzyme, accessions: Q4JEY0, gene: None, swissprot: Q4JEY0_TRIRU) Squalene monooxygenase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q92206, gene: ERG1, swissprot: ERG1_CANAL) | studied on experimental dermatophytosis | Benzylamine Antifungal (Code: N0000175875) Benzylamines (Code: N0000007566) antifungal drug (Code: CHEBI:86327) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1996-10-18 FDA | |
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| hexocyclium | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) | None | None FDA | |
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| amorolfine | None | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| mecloxamine | None | |
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| pazufloxacin | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antitubercular Agents (Code: D000995) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| phenolphthalein | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Thymidylate synthase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00469, gene: thyA, swissprot: TYSY_LACCA) Thymidylate synthase (Organism: Enterococcus faecalis (strain ATCC 700802 / V583), class: Enzyme, accessions: Q834R3, gene: thyA, swissprot: TYSY_ENTFA) Thymidylate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A884, gene: thyA, swissprot: TYSY_ECOLI) | An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic. | Indicators and Reagents (Code: D007202) | |
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| fluvoxamine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) | A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS. | Serotonin Reuptake Inhibitor (Code: N0000175696) Anti-Anxiety Agents (Code: D014151) serotonin uptake inhibitor (Code: CHEBI:50949) anxiolytic drug (Code: CHEBI:35474) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 CYP2C19 Inhibitors (Code: D065689) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) Tranquilizing Agents (Code: D014149) | 1994-12-05 FDA | 4ENH 4MM9 6AWP |
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| methscopolamine | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors. | Anticholinergic (Code: N0000175574) Cholinergic Antagonists (Code: N0000175370) Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | 1953-04-09 FDA | 4U16 |
|
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| oxymesterone | None | |
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| bietamiverine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) | None | |
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| tiemonium | None | |
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| eltanolone | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties. | Anesthetics (Code: D000777) intravenous anaesthetic (Code: CHEBI:38877) sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 5O8F |
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| tridihexethyl | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | synonym Pathilon refers to chloride; RN given refers to parent cpd; structure | anti-ulcer drug (Code: CHEBI:49201) muscarinic antagonist (Code: CHEBI:48876) antispasmodic drug (Code: CHEBI:53784) | 1954-09-15 FDA | |
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| lixisenatide | Glucagon-like peptide 1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P43220, gene: GLP1R, swissprot: GLP1R_HUMAN) | A synthetic GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist that binds GLP-1 receptor that is used to control blood sugar levels in patients with TYPE 2 DIABETES; amino acid sequence is H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSK KKKKK-NH2 (ZP10A). | Hypoglycemic Agents (Code: D007004) GLP-1 Receptor Agonist (Code: N0000178480) Glucagon-Like Peptide 1 (Code: N0000170335) Glucagon-like Peptide-1 (GLP-1) Agonists (Code: N0000020058) neuroprotective agent (Code: CHEBI:63726) hypoglycemic agent (Code: CHEBI:35526) | 2016-07-27 FDA 2013-02-01 EMA | |
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| tiludronic acid | Matrix metalloproteinase-14 (Organism: Homo sapiens, class: Enzyme, accessions: P50281, gene: MMP14, swissprot: MMP14_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Neutrophil collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P22894, gene: MMP8, swissprot: MMP8_HUMAN) V-type proton ATPase 116 kDa subunit a isoform 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13488, gene: TCIRG1, swissprot: VPP3_HUMAN) Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) | a bone resorption inhibitor; an antihypercalcemic agent; used in the tratment of Paget's disease; used in the treatment and prevention of osteoporosis; structure given in first source | Bisphosphonate (Code: N0000175579) Diphosphonates (Code: N0000007707) Bone Density Conservation Agents (Code: D050071) | 1997-03-07 FDA | |
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| clotiazepam | None | |
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| chlorpromazine | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) Transient receptor potential cation channel subfamily V member 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: O35433, gene: Trpv1, swissprot: TRPV1_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Ryanodine receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P21817, gene: RYR1, swissprot: RYR1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) antiemetic (Code: CHEBI:50919) dopaminergic antagonist (Code: CHEBI:48561) phenothiazine antipsychotic drug (Code: CHEBI:37930) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1957-09-18 FDA | 3APX 3LK0 4MA8 5G08 5LG3 5NUJ 5NUK 5NUM 5NUN |
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| ibandronic acid | Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Geranylgeranyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: O95749, gene: GGPS1, swissprot: GGPPS_HUMAN) Squalene synthase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q02769, gene: Fdft1, swissprot: FDFT_RAT) Farnesyl pyrophosphate synthase (Organism: Rattus norvegicus, class: Unclassified, accessions: P05369, gene: Fdps, swissprot: FPPS_RAT) | None | Bisphosphonate (Code: N0000175579) Diphosphonates (Code: N0000007707) Bone Density Conservation Agents (Code: D050071) | 2003-05-16 FDA | 2F94 4UMJ |
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| dexbrompheniramine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1963-10-18 FDA | |
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| norfloxacin | GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Multidrug resistance protein mdtK (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P37340, gene: mdtK, swissprot: MDTK_ECOLI) DNA topoisomerase 4 subunit A (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0C1U9, gene: parC, swissprot: PARC_STAAU) DNA gyrase subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4, gene: gyrA, swissprot: GYRA_ECOLI) DNA topoisomerase 4 subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2, gene: parC, swissprot: PARC_ECOLI) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P14867, gene: GABRA1, swissprot: GBRA1_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-5 (Organism: Homo sapiens, class: Ion channel, accessions: P31644, gene: GABRA5, swissprot: GBRA5_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903, gene: GABRA3, swissprot: GBRA3_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47869, gene: GABRA2, swissprot: GBRA2_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-4 (Organism: Homo sapiens, class: Ion channel, accessions: P48169, gene: GABRA4, swissprot: GBRA4_HUMAN) DNA topoisomerase 2-beta (Organism: Homo sapiens, class: Enzyme, accessions: Q02880, gene: TOP2B, swissprot: TOP2B_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-6 (Organism: Homo sapiens, class: Ion channel, accessions: Q16445, gene: GABRA6, swissprot: GBRA6_HUMAN) | A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE. | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1986-10-31 FDA | |
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| oxetorone | treatment of migraine; RN given refers to parent cpd; structure | |
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| epalrestat | Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) Sorbitol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: Q00796, gene: SORD, swissprot: DHSO_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Alcohol dehydrogenase [NADP(+)] (Organism: Homo sapiens, class: Enzyme, accessions: P14550, gene: AKR1A1, swissprot: AK1A1_HUMAN) Alcohol dehydrogenase [NADP(+)] (Organism: Rattus norvegicus, class: Enzyme, accessions: P51635, gene: Akr1a1, swissprot: AK1A1_RAT) Aldo-keto reductase family 1 member B10 (Organism: Homo sapiens, class: Enzyme, accessions: O60218, gene: AKR1B10, swissprot: AK1BA_HUMAN) Alcohol dehydrogenase [NADP(+)] (Organism: Sus scrofa, class: Enzyme, accessions: P50578, gene: AKR1A1, swissprot: AK1A1_PIG) | None | Enzyme Inhibitors (Code: D004791) | 1992-01-01 YEAR INTRODUCED | |
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| cyclodrine | None | |
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| lanoconazole | None | |
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| glyhexamide | None | |
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| chloroquine | Histidine-rich protein PFHRP-II (Organism: Plasmodium falciparum, class: Cytosolic other, accessions: P05227, gene: None, swissprot: HRP1_PLAFA) Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Riboflavin-binding protein (Organism: Gallus gallus, class: Unclassified, accessions: P02752, gene: None, swissprot: RBP_CHICK) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. | Amebicides (Code: D000563) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anthelmintics (Code: D000871) antirheumatic drug (Code: CHEBI:35842) dermatologic drug (Code: CHEBI:50177) antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antimalarials (Code: D000962) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antirheumatic Agents (Code: D018501) Filaricides (Code: D005369) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1949-10-31 FDA | 1CET 4FGK 4FGL 4V2O |
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| enoxacin | DNA gyrase subunit A (Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), class: Enzyme, accessions: P43700, gene: gyrA, swissprot: GYRA_HAEIN) V-type proton ATPase subunit B, brain isoform (Organism: Homo sapiens, class: Enzyme, accessions: P21281, gene: ATP6V1B2, swissprot: VATB2_HUMAN) Topoisomerase IV (Organism: Neisseria gonorrhoeae, class: Enzyme, accessions: P48374|Q5EP76, gene: parC|topB, swissprot: PARC_NEIGO|Q5EP76_NEIGO) DNA gyrase (Organism: Neisseria gonorrhoeae, class: Enzyme, accessions: P22118|P48371, gene: gyrA|gyrB, swissprot: GYRA_NEIGO|GYRB_NEIGO) | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1991-12-31 FDA | |
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| mycophenolic acid | Inosine-5'-monophosphate dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P12268, gene: IMPDH2, swissprot: IMDH2_HUMAN) Inosine-5'-monophosphate dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P20839, gene: IMPDH1, swissprot: IMDH1_HUMAN) Inosine-5'-monophosphate dehydrogenase (IMPDH) (Organism: Homo sapiens, class: Enzyme, accessions: P12268|P20839, gene: IMPDH1|IMPDH2, swissprot: IMDH1_HUMAN|IMDH2_HUMAN) | Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION. | Antimetabolite Immunosuppressant (Code: N0000175613) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antineoplastic (Code: D000903) Antibiotics, Antitubercular (Code: D000904) Antineoplastic Agents (Code: D000970) Antitubercular Agents (Code: D000995) Enzyme Inhibitors (Code: D004791) | 2004-02-27 FDA | 1JR1 1ME7 1MEH 1MEI 4AF0 4FO4 4FXS |
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| eterobarb | None | |
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| mitotane | Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cholesterol side-chain cleavage enzyme, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P05108, gene: CYP11A1, swissprot: CP11A_HUMAN) Adrenodoxin, mitochondrial (Organism: Homo sapiens, class: Unclassified, accessions: P10109, gene: FDX1, swissprot: ADX_HUMAN) | A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. | Cytochrome P450 3A4 Inducers (Code: N0000185506) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) | 1970-07-08 FDA | |
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| feprazone | A pyrazole that has analgesic, anti-inflammatory, and antipyretic properties. It has been used in mild to moderate pain, fever, and inflammation associated with musculoskeletal and joint disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p15) | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| dibunate | None | |
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| camylofin | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| timepidium | None | |
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| lorazepam | Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) Anticonvulsants (Code: D000927) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Gastrointestinal Agents (Code: D005765) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1977-09-30 FDA | |
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| capobenic acid | None | |
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| lonidamine | None | Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antispermatogenic Agents (Code: D000988) Contraceptive Agents (Code: D003270) Contraceptive Agents, Male (Code: D003272) Noxae (Code: D009676) Radiation-Sensitizing Agents (Code: D011838) Reproductive Control Agents (Code: D012102) Trypanocidal Agents (Code: D014344) | |
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| carboquone | An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| famciclovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) DNA polymerase catalytic subunit (Organism: Varicella-zoster virus (strain Dumas), class: Enzyme, accessions: P09252, gene: None, swissprot: DPOL_VZVD) | prodrug of penciclovir; phosphorylated by viral thymidine kinase and subsequently cellular kinases to a penciclovir triphosphate, which inhibits herpes simplex 2 DNA polymerase in a competitive manner; RN & structure given in first source | DNA Polymerase Inhibitors (Code: N0000020060) Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000180187) Nucleoside Analog (Code: N0000175459) prodrug (Code: CHEBI:50266) antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1994-06-29 FDA | |
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| gabexate | Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Membrane primary amine oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: O08590, gene: Aoc3, swissprot: AOC3_RAT) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Tryptase alpha/beta-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q15661, gene: TPSAB1, swissprot: TRYB1_HUMAN) | A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin. | Anticoagulants (Code: D000925) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) | |
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| kebuzone | proposed antirheumatic agent; minor descriptor (75-86); on-line & INDEX MEDICUS search PHENYLBUTAZONE/AA | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| phenazocine | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) | An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095) | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| dihexyverine | None | |
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| clopidogrel | P2Y purinoceptor 12 (Organism: Homo sapiens, class: GPCR, accessions: Q9H244, gene: P2RY12, swissprot: P2Y12_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 2B6 (Organism: Homo sapiens, class: Enzyme, accessions: P20813, gene: CYP2B6, swissprot: CP2B6_HUMAN) | None | Decreased Platelet Aggregation (Code: N0000008832) P2Y12 Platelet Inhibitor (Code: N0000182142) P2Y12 Receptor Antagonists (Code: N0000182143) platelet aggregation inhibitor (Code: CHEBI:50427) anticoagulant (Code: CHEBI:50249) Hematologic Agents (Code: D006401) Neurotransmitter Agents (Code: D018377) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Platelet Aggregation Inhibitors (Code: D010975) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P2 Receptor Antagonists (Code: D058919) Purinergic P2Y Receptor Antagonists (Code: D058921) | 1998-07-15 EMA 1997-11-17 FDA | 3ME6 4H1N |
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| minodronic acid | Geranylgeranyl pyrophosphate synthase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: Q12051, gene: BTS1, swissprot: GGPPS_YEAST) Farnesyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P14324, gene: FDPS, swissprot: FPPS_HUMAN) Geranylgeranyl pyrophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: O95749, gene: GGPS1, swissprot: GGPPS_HUMAN) Farnesyl diphosphate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P22939, gene: ispA, swissprot: ISPA_ECOLI) | None | 2011-07-11 PMDA | 2E92 2EWG 2VF6 3B7L 3ICK |
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| cyclocoumarol | anticoagulant similar to, but less potent than warfarin; may cause hemorrhage if used indiscriminately; minor descriptor (76-84); on-line search 4-HYDROXYCOUMARINS (76-84); Index Medicus search 4-HYDROXYCOUMARINS (77-84), COUMARINS (76); RN given refers to cpd without isomeric designation | |
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| zeranol | A non-steroidal estrogen analog. | Estrogens (Code: D004967) Estrogens, Non-Steroidal (Code: D004968) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 4MG8 |
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| mequitazine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Trypanothione reductase (Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1), class: Unclassified, accessions: Q389T8, gene: None, swissprot: Q389T8_TRYB2) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| aprindine | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Sodium/calcium exchanger 1 (Organism: Homo sapiens, class: Transporter, accessions: P32418, gene: SLC8A1, swissprot: NAC1_HUMAN) Proteasome subunit alpha type-1 (Organism: Homo sapiens, class: Enzyme, accessions: P25786, gene: PSMA1, swissprot: PSA1_HUMAN) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1996-01-01 YEAR INTRODUCED | |
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| bisaramil | None | |
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| clostebol | None | |
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| chloramphenicol | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Chloramphenicol acetyltransferase (Organism: Salmonella typhi, class: Enzyme, accessions: P62580, gene: cat, swissprot: CAT_SALTI) Probable HTH-type transcriptional regulator TtgR (Organism: Pseudomonas putida (strain KT2440), class: Unclassified, accessions: Q88N29, gene: ttgR, swissprot: TTGR_PSEPK) | An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) | Amphenicol-class Antibacterial (Code: N0000175480) Amphenicols (Code: N0000175479) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1950-12-08 FDA | 1CLA 1K01 1NJI 1QHS 1QHY 1USQ 2JKJ 2JKL 2UXP 2XAT 3CLA 3U9F 4BN6 4CLA 4OAD 4OAE 4V7T 4V7W 4ZOW |
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| mepixanox | respiratory analeptic; RN given refers to parent cpd; & in Negwer, 5th ed, #6503 | |
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| dimefline | None | |
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| gliclazide | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) | An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion. | hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) | 1972-01-01 YEAR INTRODUCED | 4ZFC |
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| guaiapate | None | |
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| bufetolol | proposed beta adrenergic blockader similar to propranolol; minor desriptor (77-86); on line & INDEX MEDICUS search PROPANOLAMINES (77-86); RN given refers to parent compound | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | |
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| cicloprolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | |
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| piperidolate | None | |
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| cinnamaverine | None | |
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| lysergide | D(1A) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: Q61616, gene: Drd1, swissprot: DRD1_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood. | serotonergic agonist (Code: CHEBI:35941) dopamine agonist (Code: CHEBI:51065) hallucinogen (Code: CHEBI:35499) Central Nervous System Agents (Code: D002491) Hallucinogens (Code: D006213) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Serotonin Receptor Agonists (Code: D017366) | 1957-01-01 YEAR INTRODUCED | 5TVN |
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| tolciclate | None | antifungal drug (Code: CHEBI:86327) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| cyamemazine | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | phototoxic neuroleptic effects | |
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| difemerine | None | |
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| oxysonium | None | |
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| trofosfamide | cyclophosphamide analog; structure | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Mutagens (Code: D009153) Noxae (Code: D009676) | |
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| furaltadone | Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) | None | antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | |
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| efloxate | None | |
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| valaciclovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) | a prodrug of acyclovir; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyclovir; used in the management of HSV and VZV infections and the prophylaxis of HCMV infections; RN given refers to the monohydrochloride L-valine isomer | DNA Polymerase Inhibitors (Code: N0000020060) Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000180187) Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000180188) Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000175468) Nucleoside Analog (Code: N0000175459) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1995-06-23 FDA | 4AQL |
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| dolasetron | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | Dolasetron mesylate is an antinauseant and antiemetic agent. Dolasetron mesylate and its active metabolite, hydrodolasetron (MDL 74,156), are selective serotonin 5-HT3 receptor antagonists not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. The serotonin 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. | Serotonin 3 Receptor Antagonists (Code: N0000175817) Serotonin-3 Receptor Antagonist (Code: N0000175818) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | 1997-09-11 FDA | |
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| arbutin | Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) Tyrosinase (Organism: Mus musculus, class: Unclassified, accessions: P11344, gene: Tyr, swissprot: TYRO_MOUSE) | None | None FDA | |
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| amphotalide | None | |
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| oxyphenbutazone | Cyclooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P23219|P35354, gene: PTGS1|PTGS2, swissprot: PGH1_HUMAN|PGH2_HUMAN) Prostacyclin synthase (Organism: Homo sapiens, class: Enzyme, accessions: Q16647, gene: PTGIS, swissprot: PTGIS_HUMAN) fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) | A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27) | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) gout suppressant (Code: CHEBI:35845) antineoplastic agent (Code: CHEBI:35610) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1960-12-21 FDA | 1Q7A 2BXB 2BXO |
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| ditazole | None | |
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| nitracrine | Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) | |
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| escitalopram | Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | None | Serotonin Reuptake Inhibitor (Code: N0000175696) Serotonin Uptake Inhibitors (Code: N0000000109) antidepressant (Code: CHEBI:35469) | 2002-08-14 FDA | 5I71 5I73 5I75 |
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| citalopram | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Mus musculus, class: Transporter, accessions: Q61327, gene: Slc6a3, swissprot: SC6A3_MOUSE) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition. | Serotonin Reuptake Inhibitor (Code: N0000175696) serotonin uptake inhibitor (Code: CHEBI:50949) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 1998-07-17 FDA | 5I71 5I73 5I75 |
|
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| acetohexamide | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. | hypoglycemic agent (Code: CHEBI:35526) Hypoglycemic Agents (Code: D007004) | 1964-12-23 FDA | |
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| viquidil | None | |
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| quinidine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Potassium voltage-gated channel subfamily H member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O95259, gene: KCNH1, swissprot: KCNH1_HUMAN) Potassium voltage-gated channel subfamily A member 7 (Organism: Homo sapiens, class: Ion channel, accessions: Q96RP8, gene: KCNA7, swissprot: KCNA7_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) Potassium voltage-gated channel subfamily D member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63881, gene: Kcnd2, swissprot: KCND2_RAT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Equilibrative nucleoside transporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q7RTT9, gene: SLC29A4, swissprot: S29A4_HUMAN) Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) Potassium channel subfamily T member 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q9Z258, gene: Kcnt1, swissprot: KCNT1_RAT) | An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. | Antiarrhythmic (Code: N0000175426) Cytochrome P450 2D6 Inhibitor (Code: N0000182135) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Anti-Arrhythmia Agents (Code: D000889) muscarinic antagonist (Code: CHEBI:48876) anti-arrhythmia drug (Code: CHEBI:38070) alpha-adrenergic antagonist (Code: CHEBI:37890) antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Cytochrome P-450 CYP2D6 Inhibitors (Code: D065690) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1950-07-12 FDA | 4WNU |
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| dorzolamide | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | topically effective ocular hypotensive carbonic anhydrase inhibitor; RN refers to mono-HCl (4S-trans)-isomer | Carbonic Anhydrase Inhibitor (Code: N0000175517) antihypertensive agent (Code: CHEBI:35674) antiglaucoma drug (Code: CHEBI:39456) Antihypertensive Agents (Code: D000959) Carbonic Anhydrase Inhibitors (Code: D002257) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) | 1994-12-09 FDA | 1CIL 3FW3 4K13 4M2U 4M2W 6BC9 |
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| etonogestrel | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) | metabolite of DESOGESTREL; structure given in first source; Implanon: implant containing etonogestrel (3-keto-desogestrel) | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) contraceptive drug (Code: CHEBI:49323) female contraceptive drug (Code: CHEBI:49324) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Reproductive Control Agents (Code: D012102) | 2001-10-03 FDA | |
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| diampromide | None | |
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| vorozole | Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) | None | Antineoplastic Agents (Code: D000970) Aromatase Inhibitors (Code: D047072) Enzyme Inhibitors (Code: D004791) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | |
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| prazepam | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A benzodiazepine that is used in the treatment of ANXIETY DISORDERS. | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | None FDA | |
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| elcatonin | synthetic S-S bond between 1-7 amino acids displaced by C-C bond; deamino dicarba analog of eel calcitonin; has been given orphan drug approval for intrathecal treatment of intractable pain | |
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| ergometrine | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) | An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties. | oxytocic (Code: CHEBI:36063) diagnostic agent (Code: CHEBI:33295) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) | |
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| mecillinam | Penicillin-binding protein 2 (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD65, gene: mrdA, swissprot: PBP2_ECOLI) | An amidinopenicillanic acid derivative with broad spectrum antibacterial action. | antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | None FDA | |
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| bisoprolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) antihypertensive agent (Code: CHEBI:35674) beta-adrenergic antagonist (Code: CHEBI:35530) anti-arrhythmia drug (Code: CHEBI:38070) sympatholytic agent (Code: CHEBI:66991) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) | 1992-07-31 FDA | |
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| ifenprodil | Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) Glutamate NMDA receptor; GRIN1/GRIN2B (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q13224, gene: GRIN1|GRIN2B, swissprot: NMDE2_HUMAN|NMDZ1_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) 5-hydroxytryptamine receptor 2A (Organism: Bos taurus, class: GPCR, accessions: Q75Z89, gene: HTR2A, swissprot: 5HT2A_BOVIN) Glutamate receptor ionotropic, NMDA 2B (Organism: Homo sapiens, class: Ion channel, accessions: Q13224, gene: GRIN2B, swissprot: NMDE2_HUMAN) 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase (Organism: Cavia porcellus, class: Unclassified, accessions: Q60490, gene: EBP, swissprot: EBP_CAVPO) Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) 5-hydroxytryptamine receptor 1A (Organism: Mus musculus, class: GPCR, accessions: Q64264, gene: Htr1a, swissprot: 5HT1A_MOUSE) Glutamate [NMDA] receptor subunit epsilon 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q00960, gene: Grin2b, swissprot: NMDE2_RAT) | NMDA receptor antagonist; RN given refers to parent cpd without isomeric designation; structure | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Cardiovascular Agents (Code: D002317) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 3QEL 4PE5 5EWJ |
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| etafenone | used in therapy of anigna pectoris; RN given refers to parent cpd; synonym baxacor is HCl; structure | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| dapiprazole | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | None | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) alpha-adrenergic antagonist (Code: CHEBI:37890) miotic (Code: CHEBI:51068) antipsychotic agent (Code: CHEBI:35476) ophthalmology drug (Code: CHEBI:66981) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1990-12-31 FDA | |
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| tolterodine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | An ANTIMUSCARINIC AGENT selective for the MUSCARINIC RECEPTORS of the BLADDER that is used in the treatment of URINARY INCONTINENCE and URINARY URGE INCONTINENCE. | Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) muscarinic antagonist (Code: CHEBI:48876) antispasmodic drug (Code: CHEBI:53784) muscle relaxant (Code: CHEBI:51371) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) | 1998-03-25 FDA | |
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| dimenoxadol | None | |
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| midazolam | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903|P47870|Q99928, gene: GABRA3|GABRB2|GABRG3, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P47870|Q99928, gene: GABRA1|GABRB2|GABRG3, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P31644|P47870|Q99928, gene: GABRA5|GABRB2|GABRG3, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Translocator protein (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P16257, gene: Tspo, swissprot: TSPO_RAT) GABA A receptor alpha-5/beta-3/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472|P31644|Q99928, gene: GABRA5|GABRB3|GABRG3, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Thyrotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q01717, gene: Trhr, swissprot: TRFR_RAT) | A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Adjuvants, Anesthesia (Code: D000759) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1985-12-20 FDA | 3U5K 5TE8 |
|
|
| clemizole | Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Heme oxygenase 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P23711, gene: Hmox2, swissprot: HMOX2_RAT) | None | histamine antagonist (Code: CHEBI:37956) | |
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| nipradilol | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | |
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| bumadizone | an anlgesic, antipyretic and anti-inflammatory agent; minor descriptor (75-86); on line & INDEX MEDICUS search MALONATES (75-86); RN given refers to parent cpd | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| octabenzone | None | |
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| moxestrol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372|Q92731, gene: ESR1|ESR2, swissprot: ESR1_HUMAN|ESR2_HUMAN) | None | Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| acitretin | Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate. | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) keratolytic drug (Code: CHEBI:50176) Dermatologic Agents (Code: D003879) Keratolytic Agents (Code: D007641) | 1996-10-28 FDA | |
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| hydroquinidine | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | urinary quinine metabolite; RN given refers to (9S)-isomer; structure in Merck Index, 9th ed, #4703 | Anti-Arrhythmia Agents (Code: D000889) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| ajmaline | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) | An alkaloid found in the root of RAUWOLFIA SERPENTINA, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | |
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| tiazesim | None | |
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| acepromazine | Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) | A phenothiazine that is used in the treatment of PSYCHOSES. | phenothiazine antipsychotic drug (Code: CHEBI:37930) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| aceprometazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | anxiolytic drug (Code: CHEBI:35474) sedative (Code: CHEBI:35717) histamine antagonist (Code: CHEBI:37956) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| promegestone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) | A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone. | progesterone receptor agonist (Code: CHEBI:70709) antineoplastic agent (Code: CHEBI:35610) | |
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| bunaftine | N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthamide. A proposed antiarrhythmic that prolongs myocardial refractory period and stabilizes cell membranes. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| etymemazine | None | |
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| bromochlorosalicylanilide | None | |
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| clozapine | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) UDP-glucuronosyltransferase 1-4 (Organism: Homo sapiens, class: Enzyme, accessions: P22310, gene: UGT1A4, swissprot: UD14_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: P61168, gene: Drd2, swissprot: DRD2_MOUSE) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) 5-hydroxytryptamine receptor 3A (Organism: Mus musculus, class: Ion channel, accessions: P23979, gene: Htr3a, swissprot: 5HT3A_MOUSE) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) D(3) dopamine receptor (Organism: Chlorocebus aethiops, class: GPCR, accessions: P52703, gene: DRD3, swissprot: DRD3_CHLAE) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) D(2) dopamine receptor (Organism: Chlorocebus aethiops, class: GPCR, accessions: P52702, gene: DRD2, swissprot: DRD2_CHLAE) Serotonin 2 (5-HT2) receptor (Organism: Mus musculus, class: GPCR, accessions: P34968|P35363|Q02152, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_MOUSE|5HT2B_MOUSE|5HT2C_MOUSE) 5-hydroxytryptamine receptor 2A (Organism: Bos taurus, class: GPCR, accessions: Q75Z89, gene: HTR2A, swissprot: 5HT2A_BOVIN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) D(1A) dopamine receptor (Organism: Sus scrofa, class: GPCR, accessions: P50130, gene: DRD1, swissprot: DRD1_PIG) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 1A (Organism: Mus musculus, class: GPCR, accessions: Q64264, gene: Htr1a, swissprot: 5HT1A_MOUSE) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Mus musculus, class: Unclassified, accessions: P30966, gene: Htr5a, swissprot: 5HT5A_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) Histamine H4 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q91ZY1, gene: Hrh4, swissprot: HRH4_RAT) Histamine H4 receptor (Organism: Mus musculus, class: GPCR, accessions: Q91ZY2, gene: Hrh4, swissprot: HRH4_MOUSE) Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) | A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. | Atypical Antipsychotic (Code: N0000175430) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) adrenergic antagonist (Code: CHEBI:37887) histamine antagonist (Code: CHEBI:37956) muscarinic antagonist (Code: CHEBI:48876) GABA antagonist (Code: CHEBI:65259) second generation antipsychotic (Code: CHEBI:65191) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Antagonists (Code: D018756) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) | 1989-09-26 FDA | |
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| niclosamide | Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) RAC-alpha serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31749, gene: AKT1, swissprot: AKT1_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Signal transducer and activator of transcription 3 (Organism: Homo sapiens, class: Transcription factor, accessions: P40763, gene: STAT3, swissprot: STAT3_HUMAN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) | An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48) | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anticestodal Agents (Code: D000923) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Molluscacides (Code: D008975) Pesticides (Code: D010575) | None FDA | |
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| leteprinim | a neuroprotective agent that has been shown to improve memory; induces NGF-dependent nociceptive nerve sprouting | |
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| tranilast | Hematopoietic prostaglandin D synthase (Organism: Homo sapiens, class: Enzyme, accessions: O60760, gene: HPGDS, swissprot: HPGDS_HUMAN) | antiallergic drug; potent inhibitor of homologous passive cutaneous anaphylaxis; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Allergic Agents (Code: D018926) nephroprotective agent (Code: CHEBI:76595) anti-allergic agent (Code: CHEBI:50857) antineoplastic agent (Code: CHEBI:35610) hepatoprotective agent (Code: CHEBI:62868) anti-asthmatic drug (Code: CHEBI:49167) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Platelet Aggregation Inhibitors (Code: D010975) Sensory System Agents (Code: D018689) | 2VD0 |
|
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| naloxone | Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) C-C chemokine receptor type 5 (Organism: Mus musculus, class: GPCR, accessions: P51682, gene: Ccr5, swissprot: CCR5_MOUSE) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Delta-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P32300, gene: Oprd1, swissprot: OPRD_MOUSE) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Kappa-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P34975, gene: Oprk1, swissprot: OPRK_RAT) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Bos taurus, class: GPCR, accessions: P79350, gene: OPRM1, swissprot: OPRM_BOVIN) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) | A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) central nervous system depressant (Code: CHEBI:35488) antidote to opioid poisoning (Code: CHEBI:90755) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1971-04-13 FDA | |
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| benactyzine | A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior. | Antidepressive Agents (Code: D000928) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) | |
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| norelgestromin | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | transdermal hormonal contraceptive | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Combined (Code: D003277) Reproductive Control Agents (Code: D012102) | 2001-11-20 FDA | |
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| butorphanol | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | Butorphanol is a mixed agonist-antagonist with low intrinsic activity at receptors of the mu-opioid type (morphine-like). It is also an agonist at k-opioid receptors. Its interactions with these receptors in the central nervous system apparently mediate most of its pharmacologic effects, including analgesia. | Competitive Opioid Antagonists (Code: N0000175686) Opioid Agonist/Antagonist (Code: N0000175692) Partial Opioid Agonists (Code: N0000175685) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) antitussive (Code: CHEBI:51177) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) kappa-opioid receptor agonist (Code: CHEBI:59282) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotic Antagonists (Code: D009292) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | 1978-08-22 FDA | |
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| tifenamil | None | |
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| aminopromazine | None | |
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| ranimustine | None | Antineoplastic Agents (Code: D000970) | |
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| clofibride | None | |
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| loxapine | Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Potassium channel subfamily T member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q5JUK3, gene: KCNT1, swissprot: KCNT1_HUMAN) | An antipsychotic agent used in SCHIZOPHRENIA. | antipsychotic agent (Code: CHEBI:35476) dopaminergic antagonist (Code: CHEBI:48561) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1975-02-25 FDA | |
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| diloxanide furoate | None | Amebicides (Code: D000563) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | |
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| labetalol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) CAAX prenyl protease 1 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: P47154, gene: STE24, swissprot: STE24_YEAST) CAAX prenyl protease 2 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: Q03530, gene: RCE1, swissprot: RCE1_YEAST) | A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) antihypertensive agent (Code: CHEBI:35674) sympatholytic agent (Code: CHEBI:66991) alpha-adrenergic antagonist (Code: CHEBI:37890) beta-adrenergic antagonist (Code: CHEBI:35530) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1984-08-01 FDA | |
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| dilevalol | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | None | 1989-01-01 YEAR INTRODUCED | |
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| tiapride | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | A benzamide derivative that is used as a dopamine antagonist. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| liranaftate | None | |
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| suplatast | None | Anti-Allergic Agents (Code: D018926) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) | |
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| levomepromazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) | A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) phenothiazine antipsychotic drug (Code: CHEBI:37930) dopaminergic antagonist (Code: CHEBI:48561) serotonergic antagonist (Code: CHEBI:48279) cholinergic antagonist (Code: CHEBI:48873) non-narcotic analgesic (Code: CHEBI:35481) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) | None FDA | |
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| promestriene | 3 propyl-ether-17 beta-methyl-ether of ESTRADIOL | |
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| retinol acetate | Retinol-binding protein 4 (Organism: Homo sapiens, class: Secreted, accessions: P02753, gene: RBP4, swissprot: RET4_HUMAN) Beta-lactoglobulin (Organism: Bos taurus, class: Unclassified, accessions: P02754, gene: LGB, swissprot: LACB_BOVIN) | None | Adjuvants, Immunologic (Code: D000276) Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Protective Agents (Code: D020011) | None FDA | |
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| stanozolol | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | A synthetic steroid that has anabolic and androgenic properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1194) | Anabolic Agents (Code: D045930) Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1962-01-09 FDA | |
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| ciclonium | None | |
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| oxazolam | None | |
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| clorexolone | None | |
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| eberconazole | None | |
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| nitisinone | 4-hydroxyphenylpyruvate dioxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P32754, gene: HPD, swissprot: HPPD_HUMAN) 4-hydroxyphenylpyruvate dioxygenase (Organism: Sus scrofa, class: Enzyme, accessions: Q02110, gene: HPD, swissprot: HPPD_PIG) | Nitisinone is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme upstream of FAH in the tyrosine catabolic pathway. By inhibiting the normal catabolism of tyrosine in patients with hereditary tyrosinemia type 1 (HT-1), nitisinone prevents the accumulation of the catabolic intermediates maleylacetoacetate and fumarylacetoacetate. In patients with HT-1, these catabolic intermediates are converted to the toxic metabolites succinylacetone and succinylacetoacetate, which are responsible for the observed liver and kidney toxicity. | Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor (Code: N0000175809) Hydroxyphenylpyruvate Dioxygenase Inhibitors (Code: N0000175808) Enzyme Inhibitors (Code: D004791) | 2005-02-21 EMA 2002-01-18 FDA | |
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| flumethiazide | None | |
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| etofylline nicotinate | None | |
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| paroxetine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Sodium-dependent dopamine transporter (Organism: Mus musculus, class: Transporter, accessions: Q61327, gene: Slc6a3, swissprot: SC6A3_MOUSE) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Quinolone resistance protein NorA (Organism: Staphylococcus aureus, class: Transporter, accessions: P0A0J7, gene: norA, swissprot: NORA_STAAU) P2X purinoceptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q99571, gene: P2RX4, swissprot: P2RX4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) | A serotonin uptake inhibitor that is effective in the treatment of depression. | Serotonin Reuptake Inhibitor (Code: N0000175696) anxiolytic drug (Code: CHEBI:35474) serotonin uptake inhibitor (Code: CHEBI:50949) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Cytochrome P-450 CYP2D6 Inhibitors (Code: D065690) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) | 1992-12-29 FDA | 3V5W 4JLT 4L9I 4MM4 5I6X 6AWN 6F6I |
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| trilostane | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Organism: Homo sapiens, class: Enzyme, accessions: P26439, gene: HSD3B2, swissprot: 3BHS2_HUMAN) | inhibits conversion of pregnenolone to progesterone; adrenal blocking agent used in treatment of Cushing's syndrome | Abortifacient Agents (Code: D000019) Abortifacient Agents, Steroidal (Code: D000021) antineoplastic agent (Code: CHEBI:35610) abortifacient (Code: CHEBI:50691) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Reproductive Control Agents (Code: D012102) | None FDA | |
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| bornaprine | beneficial effect in Parkinsonism due to inhibition of muscarinic or nicotinic transmission | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | |
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| androisoxazole | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | None | 1961-01-01 YEAR INTRODUCED | |
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| prenylamine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Voltage-gated L-type calcium channel (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002|P27732|Q02485, gene: Cacna1c|Cacna1d|Cacna1s, swissprot: CAC1C_RAT|CAC1D_RAT|CAC1S_RAT) | A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406) | Adrenergic Agents (Code: D018663) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | |
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| cloperastine | None | |
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| flurbiprofen axetil | an analgesic | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| malathion | Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) Acetylcholinesterase (Organism: Pediculus humanus capitis, class: Enzyme, accessions: A2PZ98, gene: Ace1, swissprot: A2PZ98_9NEOP) | A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes. | Cholinesterase Inhibitor (Code: N0000175723) insecticide (Code: CHEBI:24852) scabicide (Code: CHEBI:73333) agrochemical (Code: CHEBI:33286) pediculicide (Code: CHEBI:38706) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Insecticides (Code: D007306) Neurotransmitter Agents (Code: D018377) Pesticides (Code: D010575) | 1982-08-02 FDA | |
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| almecillin | None | |
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| oxomemazine | selective for M1 muscarinic receptors | |
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| mivotilate | None | |
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| desoxycortone | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE | Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoids (Code: D008901) | 1Y9R 2AA7 2ABI 2Q3Y 3RY9 4DVQ 4FNE |
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| prasterone acetate | None | |
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| dipiproverine | None | |
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| icosapent ethyl | Diacylglycerol O-acyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O75907, gene: DGAT1, swissprot: DGAT1_HUMAN) | None | anticholesteremic drug (Code: CHEBI:35821) antipsychotic agent (Code: CHEBI:35476) antidepressant (Code: CHEBI:35469) prodrug (Code: CHEBI:50266) | 2012-07-26 FDA | |
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| teprenone | ; RN given refers to isomeric cpd without isomeric designation; mixture of (5E,9E,13E) & (5Z,9E,13E)-isomers | anti-ulcer drug (Code: CHEBI:49201) cardioprotective agent (Code: CHEBI:77307) hepatoprotective agent (Code: CHEBI:62868) nephroprotective agent (Code: CHEBI:76595) neuroprotective agent (Code: CHEBI:63726) Anti-Ulcer Agents (Code: D000897) Antineoplastic Agents (Code: D000970) Gastrointestinal Agents (Code: D005765) | |
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| oxeladin | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| furosemide | Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Holo-[acyl-carrieir-protein] synthase (Organism: Bacillus subtilis (strain 168), class: Unclassified, accessions: P96618, gene: acpS, swissprot: ACPS_BACSU) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Homo sapiens, class: Enzyme, accessions: P28845, gene: HSD11B1, swissprot: DHI1_HUMAN) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Mus musculus, class: Enzyme, accessions: P50172, gene: Hsd11b1, swissprot: DHI1_MOUSE) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) Solute carrier family 12 member 2 (Organism: Homo sapiens, class: Transporter, accessions: P55011, gene: SLC12A2, swissprot: S12A2_HUMAN) | A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY. | Increased Diuresis at Loop of Henle (Code: N0000175366) loop diuretic (Code: CHEBI:77608) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Potassium Chloride Symporter Inhibitors (Code: D049994) | 1966-07-01 FDA | 1Z9Y 2XN5 3RF4 |
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| chlorbetamide | None | |
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| tienilic acid | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) | a novel diuretic with uricosuric action, it has been used as an antihypertensive agent, withdrawn shortly after approval due to liver toxicity | loop diuretic (Code: CHEBI:77608) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Antirheumatic Agents (Code: D018501) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Gout Suppressants (Code: D006074) Natriuretic Agents (Code: D045283) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) | 1979-05-02 FDA | |
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| hydroflumethiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) | A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Increased Diuresis (Code: N0000175359) Thiazide Diuretic (Code: N0000175419) Thiazides (Code: N0000166469) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1959-07-22 FDA | 3ILU |
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| ciprofloxacin | DNA gyrase subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4, gene: gyrA, swissprot: GYRA_ECOLI) DNA topoisomerase 4 subunit A (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0C1U9, gene: parC, swissprot: PARC_STAAU) DNA topoisomerase 4 subunit A (Organism: Bacillus subtilis (strain 168), class: Enzyme, accessions: Q45066, gene: parC, swissprot: PARC_BACSU) DNA topoisomerase 4 subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2, gene: parC, swissprot: PARC_ECOLI) DNA gyrase subunit A (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WG47, gene: gyrA, swissprot: GYRA_MYCTU) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Multidrug resistance protein mdtK (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P37340, gene: mdtK, swissprot: MDTK_ECOLI) DNA topoisomerase II (Organism: Homo sapiens, class: Enzyme, accessions: P11388|Q02880, gene: TOP2A|TOP2B, swissprot: TOP2A_HUMAN|TOP2B_HUMAN) Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) | A broad-spectrum antimicrobial carboxyfluoroquinoline. | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1987-10-22 FDA | 1OYE 1T9U 2XCT 4BVV 4KRA 5BTC |
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| piroxicam | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) antirheumatic drug (Code: CHEBI:35842) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) analgesic (Code: CHEBI:35480) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1982-04-06 FDA | |
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| protokylol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | None | None FDA | |
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| oxyclipine | None | |
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| nizatidine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Histamine H2 Receptor Antagonists (Code: N0000000151) Histamine-2 Receptor Antagonist (Code: N0000175784) anti-ulcer drug (Code: CHEBI:49201) H2-receptor antagonist (Code: CHEBI:37961) cholinergic drug (Code: CHEBI:38323) Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Neurotransmitter Agents (Code: D018377) | 1988-04-12 FDA | |
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| glypinamide | None | |
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| zotepine | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) | None | second generation antipsychotic (Code: CHEBI:65191) alpha-adrenergic drug (Code: CHEBI:48539) serotonergic drug (Code: CHEBI:48278) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| dibromol | None | |
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| zanamivir | Neuraminidase (Organism: Influenza B virus (strain B/Victoria/3/1985), class: Enzyme, accessions: P16207, gene: NA, swissprot: NRAM_INBVI) Neuraminidase (Organism: Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1)), class: Enzyme, accessions: Q2LFS1, gene: NA, swissprot: Q2LFS1_9INFA) Sialidase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UQ49, gene: NEU3, swissprot: NEUR3_HUMAN) Neuraminidase (Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1), class: Enzyme, accessions: P03468, gene: NA, swissprot: NRAM_I34A1) Neuraminidase (Organism: Influenza A virus (A/WSN/1933(H1N1)), class: Enzyme, accessions: B4URF0, gene: NA, swissprot: B4URF0_9INFA) Neuraminidase (Organism: Influenza B virus (strain B/Lee/1940), class: Enzyme, accessions: P03474, gene: NA, swissprot: NRAM_INBLE) Sialidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y3R4, gene: NEU2, swissprot: NEUR2_HUMAN) Neuraminidase (Organism: Influenza A virus (A/duck/Laos/25/2006(H5N1)), class: Enzyme, accessions: C4LRQ6, gene: NA, swissprot: C4LRQ6_9INFA) Neuraminidase (Organism: Influenza A virus (A/Turkey/651242/2006(H5N1)), class: Enzyme, accessions: A5Z252, gene: NA, swissprot: A5Z252_9INFA) Neuraminidase (Organism: Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)), class: Enzyme, accessions: Q6Q793, gene: None, swissprot: Q6Q793_9INFA) Neuraminidase (Organism: Influenza A virus (strain A/Aichi/2/1968 H3N2), class: Enzyme, accessions: Q75VQ4, gene: NA, swissprot: NRAM_I68A0) Neuraminidase (Organism: Influenza A virus (strain A/Wilson-Smith/1933 H1N1), class: Enzyme, accessions: P03470, gene: NA, swissprot: NRAM_I33A0) Neuraminidase (Organism: Influenza A virus (A/RI/5+/1957(H2N2)), class: Enzyme, accessions: Q194T1, gene: None, swissprot: Q194T1_9INFA) Neuraminidase (Organism: Influenza A virus (A/udorn/1972(H3N2)), class: Enzyme, accessions: Q20MD3, gene: NA, swissprot: Q20MD3_9INFA) | A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE. | Neuraminidase Inhibitor (Code: N0000175524) Neuraminidase Inhibitors (Code: N0000175436) EC 3.2.1.18 (exo-alpha-sialidase) inhibitor (Code: CHEBI:52425) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) | 1999-07-26 FDA | |
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| spectinomycin | 30S ribosomal protein S12 (Organism: Escherichia coli (strain K12), class: Cytosolic other, accessions: P0A7S3, gene: rpsL, swissprot: RS12_ECOLI) | An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1971-06-30 FDA | 1FJG 4V56 4V57 |
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| acedapsone | Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent. | antimicrobial drug (Code: CHEBI:36043) antimalarial (Code: CHEBI:38068) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Leprostatic Agents (Code: D007917) | |
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| oxitropium | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| ipratropium | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) | A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic. | Anticholinergic (Code: N0000175574) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 1986-12-29 FDA | 2X8M |
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| oxymetholone | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed) | Anabolic Agents (Code: D045930) Androgens (Code: D000728) anti-anaemic agent (Code: CHEBI:75835) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1972-01-18 FDA | |
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| alfaxalone | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Sodium- and chloride-dependent GABA transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P30531, gene: SLC6A1, swissprot: SC6A1_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | constituent of alphadione; RN given refers to (3alpha,5alpha)-isomer; structure | Anesthetics (Code: D000777) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 1972-01-01 YEAR INTRODUCED | |
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| brivudine | Thymidine kinase (Organism: Human herpesvirus 1, class: Kinase, accessions: Q9QNF7, gene: TK, swissprot: KITH_HHV1) Thymidine kinase (Organism: Cercopithecine herpesvirus 1, class: Kinase, accessions: A3RLP8, gene: UL23, swissprot: A3RLP8_CHV1) Thymidine kinase, cytosolic (Organism: Homo sapiens, class: Kinase, accessions: P04183, gene: TK1, swissprot: KITH_HUMAN) Thymidine kinase (Organism: Human herpesvirus 1 (strain SC16), class: Kinase, accessions: P06479, gene: TK, swissprot: KITH_HHV1S) | anti-herpes agent; (Z)-isomer much less active against herpes simplex virus type 1 & somewhat less active against herpes simplex virus type 2 than is the (E)-isomer; both isomers show similar activity against vaccinia virus; RN given refers to (E)-trans-isomer; structure | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1KI8 2VQS |
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| pefloxacin | DNA gyrase subunit B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES6, gene: gyrB, swissprot: GYRB_ECOLI) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) DNA gyrase subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4, gene: gyrA, swissprot: GYRA_ECOLI) | A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria. | antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1985-01-01 YEAR INTRODUCED | |
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| drotebanol | None | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| pentoxyverine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Lysosomal Pro-X carboxypeptidase (Organism: Homo sapiens, class: Enzyme, accessions: P42785, gene: PRCP, swissprot: PCP_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | None FDA | |
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| deptropine | Soluble acetylcholine receptor (Organism: Aplysia californica, class: Unclassified, accessions: Q8WSF8, gene: None, swissprot: Q8WSF8_APLCA) Acetylcholine-binding protein (Organism: Lymnaea stagnalis, class: Unclassified, accessions: P58154, gene: None, swissprot: ACHP_LYMST) | minor descriptor (65-85); on-line & Index Medicus search TROPANES (66-85); RN given refers to parent cpd | parasympatholytic (Code: CHEBI:50370) H1-receptor antagonist (Code: CHEBI:37955) muscarinic antagonist (Code: CHEBI:48876) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| tropatepine | None | |
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| bromfenac | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID). The mechanism of its action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2, prostaglandins are mediators of certain kinds of intraocular inflammation. | Cyclooxygenase Inhibitors (Code: N0000000160) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2005-03-24 FDA | 4MJQ |
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| bromazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | muscarinic antagonist (Code: CHEBI:48876) H1-receptor antagonist (Code: CHEBI:37955) | 1954-04-28 FDA | |
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| mitomycin | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) antineoplastic agent (Code: CHEBI:35610) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Cross-Linking Reagents (Code: D003432) Enzyme Inhibitors (Code: D004791) Indicators and Reagents (Code: D007202) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1981-08-24 FDA | |
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| tetroxoprim | Dihydrofolate reductase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0ABQ4, gene: folA, swissprot: DYR_ECOLI) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Dihydrofolate reductase (Organism: Salmonella typhi, class: Unclassified, accessions: Q8Z9J9, gene: folA, swissprot: Q8Z9J9_SALTI) | None | Anti-Infective Agents (Code: D000890) | |
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| pimobendan | Type-1 angiotensin II receptor (Organism: Bos taurus, class: GPCR, accessions: P25104, gene: AGTR1, swissprot: AGTR1_BOVIN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) | produces arterial & venous dilatation in dogs; structure given in first source | cardiotonic drug (Code: CHEBI:38147) vasodilator agent (Code: CHEBI:35620) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | 1994-01-01 YEAR INTRODUCED | |
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| benzylpenicillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Beta-lactamase TEM (Organism: Escherichia coli, class: Enzyme, accessions: P62593, gene: bla; blaT-3; blaT-4;, swissprot: BLAT_ECOLX) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065) | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1947-02-06 FDA | 1FXV 1GM7 1UOB 1UOF 3HUO 3KP2 5KMW |
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| proglumide | Histamine H2 receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P25102, gene: Hrh2, swissprot: HRH2_RAT) Gastrin/cholecystokinin type B receptor (Organism: Homo sapiens, class: GPCR, accessions: P32239, gene: CCKBR, swissprot: GASR_HUMAN) | A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers. | opioid analgesic (Code: CHEBI:35482) cholinergic antagonist (Code: CHEBI:48873) anti-ulcer drug (Code: CHEBI:49201) cholecystokinin antagonist (Code: CHEBI:73296) gastrointestinal drug (Code: CHEBI:55324) Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| strychnine | Taste receptor type 2 member 46 (Organism: Homo sapiens, class: GPCR, accessions: P59540, gene: TAS2R46, swissprot: T2R46_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison. | cholinergic antagonist (Code: CHEBI:48873) neurotransmitter agent (Code: CHEBI:35942) rodenticide (Code: CHEBI:33288) avicide (Code: CHEBI:33289) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) Glycine Agents (Code: D018684) Neurotransmitter Agents (Code: D018377) Noxae (Code: D009676) Poisons (Code: D011042) | 2XYS 5CFB |
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| fenalamide | None | |
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| progabide | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) | GABA agonist; structure | Anti-Dyskinesia Agents (Code: D018726) Anticonvulsants (Code: D000927) Antidepressive Agents (Code: D000928) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) GABA Agents (Code: D018682) GABA Agonists (Code: D018755) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) | 1985-01-01 YEAR INTRODUCED | |
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| lormetazepam | None | sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| isoxicam | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antirheumatic drug (Code: CHEBI:35842) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1983-01-01 YEAR INTRODUCED | 4M10 |
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| sulfachrysoidine | None | |
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| naratriptan | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) | None | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) serotonergic agonist (Code: CHEBI:35941) vasoconstrictor agent (Code: CHEBI:50514) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Vasoconstrictor Agents (Code: D014662) | 1998-02-10 FDA | |
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| almotriptan | 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) | None | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) serotonergic agonist (Code: CHEBI:35941) vasoconstrictor agent (Code: CHEBI:50514) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 2001-05-07 FDA | |
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| norpipanone | None | |
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| droprenilamine | secondary amine structurally related to prenylamine; RN given refers to parent cpd; synonym MG 8926 refers to HCl; structure | |
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| pirifibrate | None | |
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| hydroxychloroquine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Hemoglobin subunit alpha (Organism: Homo sapiens, class: Secreted, accessions: P69905, gene: HBA1, swissprot: HBA_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Toll-like receptor 7 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q9NYK1, gene: TLR7, swissprot: TLR7_HUMAN) Toll-like receptor 9 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q9NR96, gene: TLR9, swissprot: TLR9_HUMAN) | A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970) | Antirheumatic Agent (Code: N0000175713) antirheumatic drug (Code: CHEBI:35842) dermatologic drug (Code: CHEBI:50177) antimalarial (Code: CHEBI:38068) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) | 1955-04-18 FDA | |
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| nifurzide | None | |
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| dicoumarol | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) NAD(P)H dehydrogenase [quinone] 1 (Organism: Homo sapiens, class: Enzyme, accessions: P15559, gene: NQO1, swissprot: NQO1_HUMAN) Urease (Organism: Canavalia ensiformis, class: Enzyme, accessions: P07374, gene: None, swissprot: UREA_CANEN) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), class: Enzyme, accessions: Q5NGQ3, gene: fabI, swissprot: Q5NGQ3_FRATT) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) Proprotein convertase subtilisin/kexin type 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q16549, gene: PCSK7, swissprot: PCSK7_HUMAN) ATP phosphoribosyltransferase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WMN1, gene: hisG, swissprot: HIS1_MYCTU) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Vitamin K epoxide reductase complex subunit 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BQB6, gene: VKORC1, swissprot: VKOR1_HUMAN) | An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. | anticoagulant (Code: CHEBI:50249) Anticoagulants (Code: D000925) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Uncoupling Agents (Code: D014475) | 1944-07-31 FDA | |
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| acebutolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action. | beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) beta-adrenergic antagonist (Code: CHEBI:35530) anti-arrhythmia drug (Code: CHEBI:38070) antihypertensive agent (Code: CHEBI:35674) sympathomimetic agent (Code: CHEBI:35524) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | 1984-12-28 FDA | |
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| fluoxymesterone | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | An anabolic steroid that has been used in the treatment of male HYPOGONADISM, delayed puberty in males, and in the treatment of breast neoplasms in women. | Anabolic Agents (Code: D045930) Androgen (Code: N0000175824) Androgen Receptor Agonists (Code: N0000000146) Androstanes (Code: N0000008241) antineoplastic agent (Code: CHEBI:35610) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1956-10-15 FDA | |
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| fentanyl | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Delta-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P32300, gene: Oprd1, swissprot: OPRD_MOUSE) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Monoamine oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P21397|P27338, gene: MAOA|MAOB, swissprot: AOFA_HUMAN|AOFB_HUMAN) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) | A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Adjuvants, Anesthesia (Code: D000759) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) intravenous anaesthetic (Code: CHEBI:38877) anaesthetic (Code: CHEBI:38867) adjuvant (Code: CHEBI:60809) anaesthesia adjuvant (Code: CHEBI:60807) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1968-02-19 FDA | 5TZO |
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| buzepide metiodide | component of vesadol | |
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| nifurfoline | None | |
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| ufenamate | None | |
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| chlorproethazine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) | |
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| linezolid | Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) | An oxazolidinone and acetamide derived ANTI-BACTERIAL AGENT and PROTEIN SYNTHESIS INHIBITOR that is used in the treatment of GRAM-POSITIVE BACTERIAL INFECTIONS of the skin and respiratory tract. | Oxazolidinone Antibacterial (Code: N0000175495) Oxazolidinones (Code: N0000007568) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 2000-04-18 FDA | 3CPW 3DLL 4K7Q 4WFA |
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| disufenton | a nitrone benzene bissulfonate in development for stroke; has neuroprotective activity | Antioxidants (Code: D000975) Cardiovascular Agents (Code: D002317) Protective Agents (Code: D020011) | |
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| tenoxicam | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1987-01-01 YEAR INTRODUCED | |
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| propanidid | An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918) | Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | |
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| pargeverine | used as premedication when performing endoscopic retrograde cholangiopancreatography (ERCP) | |
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| olopatadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) | An antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS. | Decreased Histamine Release (Code: N0000175628) Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Inhibitor (Code: N0000175519) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Allergic Agents (Code: D018926) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1996-12-18 FDA | |
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| famotidine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Heat shock protein HSP 90-alpha (Organism: Homo sapiens, class: Cytosolic other, accessions: P07900, gene: HSP90AA1, swissprot: HS90A_HUMAN) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Histamine H2 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P47747, gene: HRH2, swissprot: HRH2_CAVPO) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) | A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. | Histamine H2 Receptor Antagonists (Code: N0000000151) Histamine-2 Receptor Antagonist (Code: N0000175784) H2-receptor antagonist (Code: CHEBI:37961) anti-ulcer drug (Code: CHEBI:49201) Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Neurotransmitter Agents (Code: D018377) | 1986-10-15 FDA | |
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| decimemide | None | |
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| danazol | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Steryl-sulfatase (Organism: Homo sapiens, class: Enzyme, accessions: P08842, gene: STS, swissprot: STS_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Androgen (Code: N0000175824) Androgen Receptor Agonists (Code: N0000000146) Androstanes (Code: N0000008241) anti-estrogen (Code: CHEBI:50751) estrogen antagonist (Code: CHEBI:50837) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1976-06-21 FDA | |
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| amineptine | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) | used in treatment of neuroses with psychoasthenic, anxio-phobic & depressive manifestations; synonym S 1694 refers to HCl; structure | dopamine uptake inhibitor (Code: CHEBI:51039) antidepressant (Code: CHEBI:35469) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| fenpiverinium | None | |
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| suloctidil | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312) | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| fenquizone | None | Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| idebenone | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) | None | Antioxidants (Code: D000975) Protective Agents (Code: D020011) | 2015-09-08 EMA | |
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| lisuride | 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS). | antiparkinson drug (Code: CHEBI:48407) serotonergic agonist (Code: CHEBI:35941) dopamine agonist (Code: CHEBI:51065) antidyskinesia agent (Code: CHEBI:66956) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | |
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| UREA C-13 | None | Carbon Radioisotopes (Code: N0000166118) Helicobacter pylori Diagnostic (Code: N0000175886) Radioactive Tracers (Code: N0000166093) Urea (Code: N0000006999) | 1996-09-17 FDA 1997-08-14 EMA | |
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| pirmenol | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | an antiarrhythmic with class Ia activity | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | 1994-01-01 YEAR INTRODUCED | |
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| chlortalidone | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) | A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic. | Increased Diuresis (Code: N0000175359) Thiazide-like Diuretic (Code: N0000175420) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1960-04-07 FDA | 3F4X |
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| brodimoprim | Dihydrofolate reductase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0ABQ4, gene: folA, swissprot: DYR_ECOLI) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Dihydrofolate reductase (Organism: Gallus gallus, class: Enzyme, accessions: P00378, gene: DHFR, swissprot: DYR_CHICK) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Dihydrofolate reductase (Organism: Salmonella typhi, class: Unclassified, accessions: Q8Z9J9, gene: folA, swissprot: Q8Z9J9_SALTI) | inhibits dihydrofolate reductase | antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) | 1993-01-01 YEAR INTRODUCED | |
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| cefacetrile | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) | A derivative of 7-aminocephalosporanic acid. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| mofezolac | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) | Cyclooxygenase 1 inhibitor; ; RN from Toxlit | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None PMDA | 5WBE |
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| topiramate | Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Carbonic anhydrase V (Organism: Homo sapiens, class: Enzyme, accessions: P35218|Q9Y2D0, gene: CA5A|CA5B, swissprot: CAH5A_HUMAN|CAH5B_HUMAN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P27139, gene: Ca2, swissprot: CAH2_RAT) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Glutamate receptor ionotropic AMPA (Organism: Homo sapiens, class: Ion channel, accessions: P42261|P42262|P42263|P48058, gene: GRIA1|GRIA2|GRIA3|GRIA4, swissprot: GRIA1_HUMAN|GRIA2_HUMAN|GRIA3_HUMAN|GRIA4_HUMAN) Glutamate receptor ionotropic kainate (Organism: Homo sapiens, class: Ion channel, accessions: P39086|Q13002|Q13003|Q16099|Q16478, gene: GRIK1|GRIK2|GRIK3|GRIK4|GRIK5, swissprot: GRIK1_HUMAN|GRIK2_HUMAN|GRIK3_HUMAN|GRIK4_HUMAN|GRIK5_HUMAN) | an anticonvulsant drug | Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) anticonvulsant (Code: CHEBI:35623) Anti-Obesity Agents (Code: D019440) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | 2007-07-01 PMDA 1996-12-24 FDA | 3HKU 3LXE 5JNA |
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| papaverine | Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Organism: Homo sapiens, class: Enzyme, accessions: Q13370, gene: PDE3B, swissprot: PDE3B_HUMAN) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9QYJ6, gene: Pde10a, swissprot: PDE10_RAT) Phosphodiesterase 1 (Organism: Bos taurus, class: Enzyme, accessions: P14100|Q01061, gene: PDE1A|PDE1B, swissprot: PDE1A_BOVIN|PDE1B_BOVIN) Cyclic AMP-specific phosphodiesterase SSPDE4A1A (Organism: Sus scrofa, class: Enzyme, accessions: O77823, gene: PDE4A, swissprot: O77823_PIG) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) cGMP-dependent 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O00408, gene: PDE2A, swissprot: PDE2A_HUMAN) Phosphodiesterase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P54750|Q01064|Q14123, gene: PDE1A|PDE1B|PDE1C, swissprot: PDE1A_HUMAN|PDE1B_HUMAN|PDE1C_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Phosphodiesterase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q01066|Q63421|Q9EPR9, gene: Pde1a|Pde1b|Pde1c, swissprot: PDE1B_RAT|PDE1C_RAT|Q9EPR9_RAT) Cyclic nucleotide phosphodiesterase PDE3A (Organism: Sus scrofa, class: Enzyme, accessions: Q9XSW7, gene: None, swissprot: Q9XSW7_PIG) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y233, gene: PDE10A, swissprot: PDE10_HUMAN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Protein-arginine deiminase type-4 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UM07, gene: PADI4, swissprot: PADI4_HUMAN) | An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. | Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase Inhibitors (Code: D010726) Urological Agents (Code: D064804) Vasodilator Agents (Code: D014665) | None FDA | 2WEY 3IAK |
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| xamoterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) | A phenoxypropanolamine derivative that is a selective beta-1-adrenergic agonist. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-1 Receptor Agonists (Code: D058665) Adrenergic beta-Agonists (Code: D000318) Neurotransmitter Agents (Code: D018377) | |
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| panipenem | synthetic cpd; structure given in first source | |
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| pipethanate | None | |
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| nalmefene | Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) | None | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1995-04-17 FDA | |
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| methylergometrine | 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) | A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed) | Ergolines (Code: N0000007618) Ergot Derivative (Code: N0000175827) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) | 1946-11-19 FDA | |
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| levopropoxyphene | A propionate derivative that is used to suppress coughing. | antitussive (Code: CHEBI:51177) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | 1962-03-21 FDA | |
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| dextropropoxyphene | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1957-08-16 FDA | |
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| propyromazine | Spasmolytic and anticholinergic agent | |
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| halazepam | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1981-09-24 FDA | |
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| disopyramide | G protein-activated inward rectifier potassium channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: P48544, gene: KCNJ5, swissprot: KCNJ5_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1977-09-01 FDA | 3APW |
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| perazine | A phenothiazine antipsychotic with actions and uses similar to those of CHLORPROMAZINE. Extrapyramidal symptoms may be more common than other side effects. | phenothiazine antipsychotic drug (Code: CHEBI:37930) dopaminergic antagonist (Code: CHEBI:48561) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| rociverine | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| hexetidine | A bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antifungal Agents (Code: D000935) | |
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| metipamide | diuretic with a hypotensive effect | |
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| pirisudanol | cerebral stimulant; RN given refers to parent cpd; synonym stivane refers to dimaleate; structure | |
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| pentamidine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Protein-tyrosine phosphatase 4A3 (Organism: Homo sapiens, class: Enzyme, accessions: O75365, gene: PTP4A3, swissprot: TP4A3_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Trypsin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P07477, gene: PRSS1, swissprot: TRY1_HUMAN) Glutamate NMDA receptor; GRIN1/GRIN2A (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q12879, gene: GRIN1|GRIN2A, swissprot: NMDE1_HUMAN|NMDZ1_HUMAN) Acrosin (Organism: Sus scrofa, class: Unclassified, accessions: P08001, gene: ACR, swissprot: ACRO_PIG) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Amiloride-sensitive amine oxidase [copper-containing] (Organism: Homo sapiens, class: Enzyme, accessions: P19801, gene: AOC1, swissprot: AOC1_HUMAN) Suppressor of tumorigenicity 14 protein (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y5Y6, gene: ST14, swissprot: ST14_HUMAN) Protein S100-B (Organism: Homo sapiens, class: Cytosolic other, accessions: P04271, gene: S100B, swissprot: S100B_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Spermidine/spermine N(1)-acetyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P21673, gene: SAT1, swissprot: SAT1_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Antiprotozoal (Code: N0000175485) trypanocidal drug (Code: CHEBI:36335) anti-inflammatory agent (Code: CHEBI:67079) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Trypanocidal Agents (Code: D014344) | 1984-10-16 FDA | 1D64 1RKW 3CR4 3CR5 3EY0 3GY3 3HII |
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| flutrimazole | Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) | None | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| poldine | major descriptor (66-86); on-line search BENZILATES (66-86); INDEX MEDICUS search POLDINE (66-86); RN given refers to parent cpd | |
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| parapenzolate | None | |
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| methanthelinium | Muscarinic acetylcholine receptor (Organism: Homo sapiens, class: GPCR, accessions: P08172|P08173|P08912|P11229|P20309, gene: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5, swissprot: ACM1_HUMAN|ACM2_HUMAN|ACM3_HUMAN|ACM4_HUMAN|ACM5_HUMAN) | an anticholinergic agent used as an adjunctive therapy in peptic ulcer | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | 1951-07-03 FDA | |
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| mepenzolate | Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | anticholinergic, antispasmodic agent; RN given refers to parent cpd; structure | Anticholinergic (Code: N0000175574) Cholinergic Antagonists (Code: N0000175370) | 1956-11-14 FDA | |
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| norethindrone acetate | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | used for long-term contraception; structure in Negwer, 5th ed, #4935 | synthetic oral contraceptive (Code: CHEBI:49326) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1973-04-30 FDA | |
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| canrenone | Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) | A synthetic pregnadiene compound with anti-aldosterone activity. | Diuretics (Code: D004232) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoid Receptor Antagonists (Code: D000451) Natriuretic Agents (Code: D045283) | |
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| ethylhydrocupreine | None | |
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| terguride | Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | pronounced antifertility agent in rats; lactation suppressor in other species; serotonin antagonist; RN given refers to parent cpd; structure | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | None PMDA | |
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| propiomazine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) | None | phenothiazine antipsychotic drug (Code: CHEBI:37930) dopaminergic antagonist (Code: CHEBI:48561) serotonergic antagonist (Code: CHEBI:48279) muscarinic antagonist (Code: CHEBI:48876) histamine antagonist (Code: CHEBI:37956) sedative (Code: CHEBI:35717) | 1960-12-05 FDA | |
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| lucanthone | DNA-(apurinic or apyrimidinic site) lyase (Organism: Homo sapiens, class: Enzyme, accessions: P27695, gene: APEX1, swissprot: APEX1_HUMAN) | One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46) | Anthelmintics (Code: D000871) schistosomicide drug (Code: CHEBI:38941) antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) prodrug (Code: CHEBI:50266) adjuvant (Code: CHEBI:60809) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Schistosomicides (Code: D012556) | |
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| medrogestone | 6,17-Dimethylpregna-4,6-diene-3,20-dione. A synthetic progestational hormone with actions similar to those of progesterone. It is used in the treatment of menstrual irregularities and has also been employed in the treatment of prostatic hypertrophy and endometrial carcinoma. | Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) | |
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| dimethisterone | A synthetic progestational hormone without significant estrogenic or androgenic properties. It was formerly used as the progestational component in oral sequential contraceptives. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | |
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| penthienate | None | |
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| docosanoic acid | Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) | None | |
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| propanol | A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate. | protic solvent (Code: CHEBI:48356) | |
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| nitroxazepine | has pronounced sedative properties, but otherwise resembles imipramine; minor descriptor (77-84); on-line & Index Medicus search DIBENZOXAZEPINES (77-84); RN given refers to mono-HCl | |
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| thebacon | None | |
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| naltrexone | Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483, gene: Chrna4, swissprot: ACHA4_RAT) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Delta-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P32300, gene: Oprd1, swissprot: OPRD_MOUSE) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Opioid receptors; mu and delta (Organism: Mus musculus, class: GPCR, accessions: P32300|P42866, gene: Oprd1|Oprm1, swissprot: OPRD_MOUSE|OPRM_MOUSE) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) Kappa-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P34975, gene: Oprk1, swissprot: OPRK_RAT) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) central nervous system depressant (Code: CHEBI:35488) antidote to opioid poisoning (Code: CHEBI:90755) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 1984-11-20 FDA | |
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| diseptal B | None | |
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| fenetylline | None | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) | |
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| sulpiride | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) D(2) dopamine receptor (Organism: Canis familiaris, class: GPCR, accessions: Q9GJU1, gene: DRD2, swissprot: DRD2_CANFA) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed) | antidepressant (Code: CHEBI:35469) antiemetic (Code: CHEBI:50919) antipsychotic agent (Code: CHEBI:35476) dopaminergic antagonist (Code: CHEBI:48561) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1972-01-01 YEAR INTRODUCED | |
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| levosulpiride | D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | None | dopaminergic antagonist (Code: CHEBI:48561) antidepressant (Code: CHEBI:35469) antiemetic (Code: CHEBI:50919) antipsychotic agent (Code: CHEBI:35476) | |
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| cyclacillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A cyclohexylamido analog of PENICILLANIC ACID. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1979-09-13 FDA | |
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| propafenone | Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1989-11-27 FDA | |
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| clobenztropine | Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) | None | |
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| maltose | A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed) | sweetening agent (Code: CHEBI:50505) Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) | 4CN6 4QSC 4XNX 4XPA 4XPB 4XPH 4XPT 5D5A 5D5B 5D6L 5LGW |
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| lactulose | A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887) | Osmotic Laxative (Code: N0000175811) Osmotic Activity (Code: N0000010288) Acidifying Activity (Code: N0000175833) Stimulation Large Intestine Fluid/Electrolyte Secretion (Code: N0000009871) laxative (Code: CHEBI:50503) gastrointestinal drug (Code: CHEBI:55324) Gastrointestinal Agents (Code: D005765) | 1976-03-25 FDA | |
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| lactose | Galectin-9 (Organism: Homo sapiens, class: Unclassified, accessions: O00182, gene: LGALS9, swissprot: LEG9_HUMAN) Galectin-8 (Organism: Homo sapiens, class: Unclassified, accessions: O00214, gene: LGALS8, swissprot: LEG8_HUMAN) Galectin-3 (Organism: Homo sapiens, class: Unclassified, accessions: P17931, gene: LGALS3, swissprot: LEG3_HUMAN) | A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry. | Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) | 1W3A 1W8O 1ZJ0 2D6M 2EAE 2EAK 2H4I 2IHZ 2ILV 2NN8 2PEL 2WSV 2Y9G 2YVV 2Z4T 3AP4 3I8T 3NBD 3PJQ 4BME 4GA9 4OJO 4OUJ 4RKR 4WV8 4WVV 5CA3 5GW7 5JPG 5JPV 5NLD 5NLE 5NLH 5NM1 5NMJ 5T7S |
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| siccanin | None | antifungal drug (Code: CHEBI:86327) | |
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| megestrol acetate | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Appetite Stimulants (Code: D019167) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1971-08-18 FDA | |
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| flutoprazepam | Flunitrazepam is a short-acting benzodiazepine with general properties similar to diazepam. | |
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| etizolam | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1984-01-01 YEAR INTRODUCED | 4C66 |
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| triazolam | Platelet-activating factor receptor (Organism: Homo sapiens, class: GPCR, accessions: P25105, gene: PTAFR, swissprot: PTAFR_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903|P47870|Q99928, gene: GABRA3|GABRB2|GABRG3, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P47870|Q99928, gene: GABRA1|GABRB2|GABRG3, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P31644|P47870|Q99928, gene: GABRA5|GABRB2|GABRG3, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Cholecystokinin receptor type A (Organism: Rattus norvegicus, class: GPCR, accessions: P30551, gene: Cckar, swissprot: CCKAR_RAT) GABA-A receptor (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|Q16445|Q8N1C3|Q99928, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRG1|GABRG2|GABRG3, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-3/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472|P31644|Q99928, gene: GABRA5|GABRB3|GABRG3, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG3_HUMAN) | A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Adjuvants, Anesthesia (Code: D000759) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1982-11-15 FDA | |
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| acetyldihydrocodeine | None | |
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| cinchocaine | Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) topical anaesthetic (Code: CHEBI:48425) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| clotiapine | Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| clemastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) muscarinic antagonist (Code: CHEBI:48876) antipruritic drug (Code: CHEBI:59683) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1977-02-25 FDA | |
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| bromopride | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1976-01-01 YEAR INTRODUCED | |
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| lactitol | None | excipient (Code: CHEBI:75324) laxative (Code: CHEBI:50503) Cathartics (Code: D002400) Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Gastrointestinal Agents (Code: D005765) Sweetening Agents (Code: D013549) | |
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| sultosilic acid | None | |
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| formoterol | Heat shock protein HSP 90-alpha (Organism: Homo sapiens, class: Cytosolic other, accessions: P07900, gene: HSP90AA1, swissprot: HS90A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) | An ADRENERGIC BETA-2 RECEPTOR AGONIST with a prolonged duration of action. It is used to manage ASTHMA and in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) anti-asthmatic drug (Code: CHEBI:49167) beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 2001-02-16 FDA | |
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| piketoprofen | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | |
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| formebolone | None | |
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| oxyphencyclimine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | cholinergic blocking agent used as an adjunct in the treatment of peptic ulcer | None FDA | |
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| medrysone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1969-11-28 FDA | |
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| medroxyprogesterone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Aldo-keto reductase family 1 member C1 (Organism: Homo sapiens, class: Enzyme, accessions: Q04828, gene: AKR1C1, swissprot: AK1C1_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372|Q92731, gene: ESR1|ESR2, swissprot: ESR1_HUMAN|ESR2_HUMAN) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Androgen receptor (Organism: Mus musculus, class: Transcription factor, accessions: P19091, gene: Ar, swissprot: ANDR_MOUSE) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) | A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms. | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) contraceptive drug (Code: CHEBI:49323) synthetic oral contraceptive (Code: CHEBI:49326) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptive Agents, Male (Code: D003272) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | 1959-06-18 FDA | |
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| tribromometacresol | None | |
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| clotrimazole | Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Platelet-activating factor receptor (Organism: Homo sapiens, class: GPCR, accessions: P25105, gene: PTAFR, swissprot: PTAFR_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Cysteinyl leukotriene receptor 1 (Organism: Cavia porcellus, class: GPCR, accessions: Q2NNR5, gene: CYSLTR1, swissprot: CLTR1_CAVPO) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Intermediate conductance calcium-activated potassium channel protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: O15554, gene: KCNN4, swissprot: KCNN4_HUMAN) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Alpha-chymotrypsin (Organism: Bos taurus, class: Unclassified, accessions: P00766, gene: None, swissprot: CTRA_BOVIN) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) 14-alpha sterol demethylase (Organism: Neosartorya fumigata, class: Enzyme, accessions: Q96W81, gene: cyp51B, swissprot: Q96W81_ASPFM) 14-alpha sterol demethylase Cyp51A (Organism: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100), class: Enzyme, accessions: Q4WNT5, gene: None, swissprot: Q4WNT5_ASPFU) Malate dehydrogenase cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P40925, gene: MDH1, swissprot: MDHC_HUMAN) Putative cytochrome P450 130 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WPN5, gene: cyp130, swissprot: CP130_MYCTU) C-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P51679, gene: CCR4, swissprot: CCR4_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) C-X-C chemokine receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P25024, gene: CXCR1, swissprot: CXCR1_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Potassium voltage-gated channel subfamily A member 3 (Organism: Homo sapiens, class: Ion channel, accessions: P22001, gene: KCNA3, swissprot: KCNA3_HUMAN) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) 14-alpha Demethylase Inhibitors (Code: D058888) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antifungal Agents (Code: D000935) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) | 1975-02-03 FDA | 2XFH 3MDV 4XE3 |
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| trengestone | None | |
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| clorotepine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) | major tranquilizer with action similar to those of the phenothiazines; used in schizophrenic & manic psychoses; minor decriptor (77-86); on-line & INDEX MEDICUS search DIBENZOTHIEPINS (77-86); RN given refers to parent cpd without isomeric designation | |
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| niclofolan | Proposed fasciolacide. Synonyms: Dertil; Bilevon; Bay 9015. | |
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| tretoquinol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P19328|P22086|P22909|P23944|P43140, gene: Adra1a|Adra1b|Adra1d|Adra2a|Adra2b|Adra2c, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT|ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor beta (Organism: Homo sapiens, class: GPCR, accessions: P07550|P08588|P13945, gene: ADRB1|ADRB2|ADRB3, swissprot: ADRB1_HUMAN|ADRB2_HUMAN|ADRB3_HUMAN) Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) | An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) | |
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| omeprazole | Potassium-transporting ATPase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P18597|P27112, gene: ATP4A|ATP4B, swissprot: ATP4A_RABIT|ATP4B_RABIT) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) Potassium-transporting ATPase (Organism: Sus scrofa, class: Enzyme, accessions: P18434|P19156, gene: ATP4A|ATP4B, swissprot: ATP4A_PIG|ATP4B_PIG) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Fatty acid synthase (Organism: Homo sapiens, class: Enzyme, accessions: P49327, gene: FASN, swissprot: FAS_HUMAN) | A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | Proton Pump Inhibitor (Code: N0000175525) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) anti-ulcer drug (Code: CHEBI:49201) anticonvulsant (Code: CHEBI:35623) Anti-Ulcer Agents (Code: D000897) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Proton Pump Inhibitors (Code: D054328) | 1989-09-14 FDA | |
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| esomeprazole | Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) | The S-isomer of omeprazole. | Proton Pump Inhibitor (Code: N0000175525) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) histamine antagonist (Code: CHEBI:37956) anti-ulcer drug (Code: CHEBI:49201) Anti-Ulcer Agents (Code: D000897) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Proton Pump Inhibitors (Code: D054328) | 2001-02-20 FDA | |
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| bevantolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) beta-adrenergic antagonist (Code: CHEBI:35530) antihypertensive agent (Code: CHEBI:35674) anti-arrhythmia drug (Code: CHEBI:38070) Neurotransmitter Agents (Code: D018377) | 1987-01-01 YEAR INTRODUCED | |
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| clopamide | A sulfamoylbenzamide piperidine. It is considered a thiazide-like diuretic. | Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| metofoline | None | None FDA | |
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| nifedipine | Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1F (Organism: Homo sapiens, class: Ion channel, accessions: O60840, gene: CACNA1F, swissprot: CAC1F_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) C-C chemokine receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P41597, gene: CCR2, swissprot: CCR2_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Potassium voltage-gated channel subfamily A member 2 (Organism: Homo sapiens, class: Ion channel, accessions: P16389, gene: KCNA2, swissprot: KCNA2_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Oryctolagus cuniculus, class: Ion channel, accessions: P15381, gene: CACNA1C, swissprot: CAC1C_RABIT) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Cavia porcellus, class: Ion channel, accessions: O35505, gene: CACNA1C, swissprot: CAC1C_CAVPO) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Voltage-gated L-type calcium channel (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002|P27732|Q02485, gene: Cacna1c|Cacna1d|Cacna1s, swissprot: CAC1C_RAT|CAC1D_RAT|CAC1S_RAT) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Rattus norvegicus, class: Ion channel, accessions: P27732, gene: Cacna1d, swissprot: CAC1D_RAT) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Glycine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: O75311, gene: GLRA3, swissprot: GLRA3_HUMAN) Glycine receptor subunit beta (Organism: Homo sapiens, class: Ion channel, accessions: P48167, gene: GLRB, swissprot: GLRB_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) Potassium voltage-gated channel subfamily A member 1 (Organism: Mus musculus, class: Unclassified, accessions: P16388, gene: Kcna1, swissprot: KCNA1_MOUSE) Potassium voltage-gated channel subfamily A member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P63142, gene: Kcna2, swissprot: KCNA2_RAT) Potassium voltage-gated channel subfamily A member 7 (Organism: Mus musculus, class: Unclassified, accessions: Q17ST2, gene: Kcna7, swissprot: KCNA7_MOUSE) | A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) vasodilator agent (Code: CHEBI:35620) tocolytic agent (Code: CHEBI:66993) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Reproductive Control Agents (Code: D012102) Tocolytic Agents (Code: D015149) Vasodilator Agents (Code: D014665) | 1981-12-31 FDA | |
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| beclobrate | None | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| adenosine phosphate | Transient receptor potential cation channel subfamily M member 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8TD43, gene: TRPM4, swissprot: TRPM4_HUMAN) Fructose-1,6-bisphosphatase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P09467, gene: FBP1, swissprot: F16P1_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Transient receptor potential cation channel subfamily M member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O94759, gene: TRPM2, swissprot: TRPM2_HUMAN) Ketopantoate reductase (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P0A9J4, gene: panE, swissprot: PANE_ECOLI) L-lactate dehydrogenase A chain (Organism: Homo sapiens, class: Enzyme, accessions: P00338, gene: LDHA, swissprot: LDHA_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Adenylate kinase 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P29410, gene: Ak2, swissprot: KAD2_RAT) Fructose-1,6-bisphosphatase 1 (Organism: Sus scrofa, class: Enzyme, accessions: P00636, gene: FBP1, swissprot: F16P1_PIG) Alcohol dehydrogenase (Organism: Equus caballus, class: Enzyme, accessions: P00327|P00328, gene: None, swissprot: ADH1E_HORSE|ADH1S_HORSE) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O43598, gene: DNPH1, swissprot: DNPH1_HUMAN) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: O35820, gene: Dnph1, swissprot: DNPH1_RAT) | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | nutraceutical (Code: CHEBI:50733) | |
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| arsthinol | nanosuspensions of arsthinol could be used for treatment of acute promyelocytic leukaemia | |
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| nafamostat | Serine protease hepsin (Organism: Homo sapiens, class: Enzyme, accessions: P05981, gene: HPN, swissprot: HEPS_HUMAN) Hepatocyte growth factor activator (Organism: Homo sapiens, class: Enzyme, accessions: Q04756, gene: HGFAC, swissprot: HGFA_HUMAN) Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) Cationic trypsin (Organism: Bos taurus, class: Enzyme, accessions: P00760, gene: None, swissprot: TRY1_BOVIN) Trypsin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P07477, gene: PRSS1, swissprot: TRY1_HUMAN) Complement C1r subcomponent (Organism: Homo sapiens, class: Enzyme, accessions: P00736, gene: C1R, swissprot: C1R_HUMAN) Complement C1s subcomponent (Organism: Homo sapiens, class: Enzyme, accessions: P09871, gene: C1S, swissprot: C1S_HUMAN) Kallikrein-1 (Organism: Homo sapiens, class: Enzyme, accessions: P06870, gene: KLK1, swissprot: KLK1_HUMAN) Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) Acid-sensing ion channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q16515, gene: ASIC2, swissprot: ASIC2_HUMAN) Acid-sensing ion channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: P78348, gene: ASIC1, swissprot: ASIC1_HUMAN) Acid-sensing ion channel 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UHC3, gene: ASIC3, swissprot: ASIC3_HUMAN) Tryptase alpha/beta-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q15661, gene: TPSAB1, swissprot: TRYB1_HUMAN) Suppressor of tumorigenicity 14 protein (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y5Y6, gene: ST14, swissprot: ST14_HUMAN) | inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic; RN given refers to parent cpd | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Anticoagulants (Code: D000925) Antirheumatic Agents (Code: D018501) Complement Inactivating Agents (Code: D051056) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Peripheral Nervous System Agents (Code: D018373) Protease Inhibitors (Code: D011480) Sensory System Agents (Code: D018689) Serine Proteinase Inhibitors (Code: D015842) Trypsin Inhibitors (Code: D014361) | None PMDA | |
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| sulbactam pivoxyl | None | |
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| cefalexin | Penicillin-binding protein 3 (Organism: Bacillus subtilis (strain 168), class: Enzyme, accessions: P42971, gene: pbpC, swissprot: PBPC_BACSU) Solute carrier family 15 member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q16348, gene: SLC15A2, swissprot: S15A2_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1971-01-04 FDA | |
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| fedrilate | None | |
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| benzpiperylone | spelled benzopiperylone in title | |
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| repirinast | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Neurotransmitter Agents (Code: D018377) | |
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| indoramin | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) | An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent. | Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1981-01-01 YEAR INTRODUCED | |
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| clanobutin | None | |
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| embramine | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| succisulfone | None | |
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| enalaprilat | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q5EGZ1, gene: Ace2, swissprot: ACE2_RAT) Angiotensin-converting enzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P47820, gene: Ace, swissprot: ACE_RAT) | The active metabolite of ENALAPRIL and one of the potent, intravenously administered, ANGIOTENSIN-CONVERTING ENZYME INHIBITORS. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion. | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) antihypertensive agent (Code: CHEBI:35674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1988-02-09 FDA | 1UZE 2X90 |
|
|
| torsemide | Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) | an injectible or oral medication for the treatment of edema associated with congestive heart failure, renal disease and hepatic disease; Na+ 2Cl- K+ symporter inhibitor | Increased Diuresis at Loop of Henle (Code: N0000175366) antihypertensive agent (Code: CHEBI:35674) loop diuretic (Code: CHEBI:77608) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Potassium Chloride Symporter Inhibitors (Code: D049994) | 1993-08-23 FDA | |
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| acrivastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) | a second generation antihistamine | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) H1-receptor antagonist (Code: CHEBI:37955) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | 1994-03-25 FDA | |
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| intoplicine | DNA topoisomerase I, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q969P6, gene: TOP1MT, swissprot: TOP1M_HUMAN) DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) | None | |
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| bexarotene | Retinoic acid receptor RXR-alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P19793, gene: RXRA, swissprot: RXRA_HUMAN) Retinoic acid receptor RXR-beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P28702, gene: RXRB, swissprot: RXRB_HUMAN) Retinoic acid receptor RXR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P48443, gene: RXRG, swissprot: RXRG_HUMAN) Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) Retinoic acid receptor RXR-gamma (Organism: Mus musculus, class: Transcription factor, accessions: P28705, gene: Rxrg, swissprot: RXRG_MOUSE) Retinoic acid receptor RXR-alpha (Organism: Mus musculus, class: Transcription factor, accessions: P28700, gene: Rxra, swissprot: RXRA_MOUSE) Retinoic acid receptor RXR-alpha (Organism: Rattus norvegicus, class: Unclassified, accessions: Q05343, gene: Rxra, swissprot: RXRA_RAT) Retinoic acid receptor RXR-beta (Organism: Mus musculus, class: Transcription factor, accessions: P28704, gene: Rxrb, swissprot: RXRB_MOUSE) Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) | a retinoid X receptor (RXR) selective agonist | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) antineoplastic agent (Code: CHEBI:35610) Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Protective Agents (Code: D020011) | 2001-03-29 EMA 1999-12-29 FDA | 3H0A 4K6I |
|
|
| leiopyrrole | spasmolytic leioplegil is the HCl of leiopyrrole; RN given refers to leiopyrrole; no RN available for HCl; structure | |
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| oxyphenonium | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) | A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. | Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | None FDA | |
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| ethyl dibunate | None | |
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| doxefazepam | None | |
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| halocarban | None | |
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| sorivudine | Thymidine kinase (Organism: Human herpesvirus 1, class: Kinase, accessions: Q9QNF7, gene: TK, swissprot: KITH_HHV1) Thymidine kinase, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: O00142, gene: TK2, swissprot: KITM_HUMAN) Deoxynucleoside kinase (Organism: Drosophila melanogaster, class: Kinase, accessions: Q9XZT6, gene: dnk, swissprot: DNK_DROME) Thymidine kinase (Organism: Varicella-zoster virus (strain Dumas), class: Kinase, accessions: P09250, gene: None, swissprot: KITH_VZVD) | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | |
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| cloxazolam | analog of oxazolam; structure | |
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| voriconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) 14-alpha sterol demethylase (Organism: Neosartorya fumigata, class: Enzyme, accessions: Q96W81, gene: cyp51B, swissprot: Q96W81_ASPFM) 14-alpha sterol demethylase Cyp51A (Organism: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100), class: Enzyme, accessions: Q4WNT5, gene: None, swissprot: Q4WNT5_ASPFU) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) | A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) | 2002-05-24 FDA | 3MDT 4UYM 4ZE0 5HS1 6AY6 |
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| cinmetacin | None | |
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| cefradine | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semi-synthetic cephalosporin antibiotic. | antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1974-08-19 FDA | |
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| ampicillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Transient receptor potential cation channel subfamily M member 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8TD43, gene: TRPM4, swissprot: TRPM4_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) antibacterial drug (Code: CHEBI:36047) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1965-12-17 FDA | 1H8S 1NX9 2RDD 3ITA 3KP3 3NDV 4GCP 4KR4 |
|
|
| dipipanone | piperidyl analog of methadone where piperidino group replaces dimethylamino group; RN given refers to parent cpd without isomeric designation; structure | |
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| cetiedil | None | Antisickling Agents (Code: D000986) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Vasodilator Agents (Code: D014665) | |
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| loracarbef | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | 1-carbacephem antibiotic; has a broad spectrum of antimicrobial activity; structure given in first source; carbacephems differ from cephalosporins in the substitution of a sulfur atom in the dihydrothiazine ring with a methylene group to form a tetrahydropyridine ring | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1991-12-31 FDA | |
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| azasetron | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) | a selective 5-HT3 receptor antagonist; structure given in first source | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | |
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| phenoxymethylpenicillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1958-01-13 FDA | 2Z71 |
|
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| biapenem | Penicillin-binding protein 2 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q9X6V3, gene: pbpA, swissprot: Q9X6V3_PSEAI) Penicillin-binding protein 4 (Organism: Staphylococcus aureus, class: Enzyme, accessions: Q5D1E9, gene: None, swissprot: Q5D1E9_STAAU) D-ala-D-ala-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase family protein; Penicillin-binding protein 5 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q9X6V7, gene: dacA, swissprot: Q9X6V7_PSEAI) Penicillin-binding protein 1 (Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18), class: Enzyme, accessions: A1KS91, gene: ponA, swissprot: A1KS91_NEIMF) D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6 (Organism: Yersinia pestis, class: Enzyme, accessions: Q7CHG0, gene: dacC, swissprot: Q7CHG0_YERPE) | None | antibacterial drug (Code: CHEBI:36047) Anti-Infective Agents (Code: D000890) | 2002-01-01 YEAR INTRODUCED | |
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| disofenin | None | |
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| vinpocetine | Phosphodiesterase 1 (Organism: Bos taurus, class: Enzyme, accessions: P14100|Q01061, gene: PDE1A|PDE1B, swissprot: PDE1A_BOVIN|PDE1B_BOVIN) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Organism: Homo sapiens, class: Enzyme, accessions: P54750, gene: PDE1A, swissprot: PDE1A_HUMAN) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Organism: Homo sapiens, class: Enzyme, accessions: Q14123, gene: PDE1C, swissprot: PDE1C_HUMAN) | whole issue of Arzneim Forsch (23 articles) discuss this drug; Arzneim Forsch 26(10a);1976; RN given refers to parent cpd with unspecified isomeric designation | Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Neuroprotective Agents (Code: D018696) Nootropic Agents (Code: D018697) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) | |
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| loretin | None | |
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| menthyl salicylate | None | None FDA | |
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| lomefloxacin | DNA gyrase subunit A (Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), class: Enzyme, accessions: P43700, gene: gyrA, swissprot: GYRA_HAEIN) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) | A synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. | photosensitizing agent (Code: CHEBI:47868) antitubercular agent (Code: CHEBI:33231) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1992-02-21 FDA | |
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| benfluorex | None | Anti-Obesity Agents (Code: D019440) Antimetabolites (Code: D000963) Appetite Depressants (Code: D001067) Central Nervous System Agents (Code: D002491) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| moquizone | None | |
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| meloxicam | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of meloxicam, like that of other NSAIDs, may be related to prostaglandin synthetase (cyclo-oxygenase) inhibition. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antirheumatic drug (Code: CHEBI:35842) analgesic (Code: CHEBI:35480) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2000-04-13 FDA | 4M11 4O1Z |
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| pirenzepine | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Muscarinic acetylcholine receptor (Organism: Mus musculus, class: GPCR, accessions: P12657|P32211|Q920H4|Q9ERZ3|Q9ERZ4, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_MOUSE|ACM2_MOUSE|ACM3_MOUSE|ACM4_MOUSE|ACM5_MOUSE) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor DM1 (Organism: Drosophila melanogaster, class: GPCR, accessions: P16395, gene: mAChR-A, swissprot: ACM1_DROME) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Muscarinic receptor M1 (Organism: Bos taurus, class: GPCR, accessions: Q8WMX0, gene: None, swissprot: Q8WMX0_BOVIN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Muscarinic acetylcholine receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8VH26, gene: GPM3, swissprot: Q8VH26_CAVPO) Muscarinic acetylcholine receptor M4 (Organism: Rattus norvegicus, class: GPCR, accessions: P08485, gene: Chrm4, swissprot: ACM4_RAT) | An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients. | anti-ulcer drug (Code: CHEBI:49201) muscarinic antagonist (Code: CHEBI:48876) antispasmodic drug (Code: CHEBI:53784) Anti-Ulcer Agents (Code: D000897) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Gastrointestinal Agents (Code: D005765) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | |
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| epicillin | semisynthetic penicillin type antibiotic; minor descriptor (75-85); on-line & Index Medicus search AMPICILLIN/AA (75-85); RN given refers to (2s(2alpha,5alpha,6beta(S*)))-isomer | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| dipivefrine | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | used in treatment of both primary & open angle glaucoma; RN given refers to (+-)-isomer | Adrenergic Receptor Agonist (Code: N0000175883) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) prodrug (Code: CHEBI:50266) adrenergic agonist (Code: CHEBI:37886) sympathomimetic agent (Code: CHEBI:35524) antiglaucoma drug (Code: CHEBI:39456) ophthalmology drug (Code: CHEBI:66981) Neurotransmitter Agents (Code: D018377) | 1980-05-02 FDA | |
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| tamibarotene | Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) | has retinoid-binding activity | antineoplastic agent (Code: CHEBI:35610) retinoic acid receptor alpha/beta agonist (Code: CHEBI:50741) | 2005-04-11 PMDA | 2CBR |
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| pipoxolan | synonyms BR-18 & rowapraxin refer to HCl; structure | |
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| tazarotene | Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) | a topical acetylenic retinoid; a topical kerytolytic | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) keratolytic drug (Code: CHEBI:50176) prodrug (Code: CHEBI:50266) Dermatologic Agents (Code: D003879) Keratolytic Agents (Code: D007641) Noxae (Code: D009676) Teratogens (Code: D013723) | 1997-06-13 FDA | |
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| phenadoxone | None | |
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| adinazolam | Translocator protein (Organism: Homo sapiens, class: Transporter, accessions: P30536, gene: TSPO, swissprot: TSPO_HUMAN) GABA-A receptor (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|Q16445|Q8N1C3|Q99928, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRG1|GABRG2|GABRG3, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN) | None | antidepressant (Code: CHEBI:35469) sedative (Code: CHEBI:35717) anxiolytic drug (Code: CHEBI:35474) anticonvulsant (Code: CHEBI:35623) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| sulmarin | None | |
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| triflupromazine | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) | A phenothiazine used as an antipsychotic agent and as an antiemetic. | dopaminergic antagonist (Code: CHEBI:48561) antiemetic (Code: CHEBI:50919) first generation antipsychotic (Code: CHEBI:65190) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1957-09-16 FDA | |
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| posatirelin | stimulates oxygen consumption | |
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| clidinium | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | a synthetic anticholinergic agent that has antispasmodic and antisecretory effect on the gastrointestinal tract | Anticholinergic (Code: N0000175574) Decreased Parasympathetic Acetylcholine Activity (Code: N0000008779) GI Motility Alteration (Code: N0000009048) Digestive/GI System Activity Alteration (Code: N0000009022) Cholinergic Antagonists (Code: N0000175370) parasympatholytic (Code: CHEBI:50370) antispasmodic drug (Code: CHEBI:53784) anti-arrhythmia drug (Code: CHEBI:38070) Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | None FDA | |
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| epoprostenol | Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) P2Y purinoceptor 12 (Organism: Homo sapiens, class: GPCR, accessions: Q9H244, gene: P2RY12, swissprot: P2Y12_HUMAN) | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). | Prostacycline Vasodilator (Code: N0000175416) Prostaglandins I (Code: N0000011280) Vasodilation (Code: N0000009909) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | 1995-09-20 FDA | |
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| dinoprostone | Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Solute carrier family 22 member 6 (Organism: Mus musculus, class: Transporter, accessions: Q8VC69, gene: Slc22a6, swissprot: S22A6_MOUSE) Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) Prostaglandin E2 receptor EP2 subtype (Organism: Mus musculus, class: GPCR, accessions: Q62053, gene: Ptger2, swissprot: PE2R2_MOUSE) Prostaglandin E2 receptor EP1 subtype (Organism: Mus musculus, class: GPCR, accessions: P35375, gene: Ptger1, swissprot: PE2R1_MOUSE) Prostaglandin E2 receptor EP3 subtype (Organism: Mus musculus, class: GPCR, accessions: P30557, gene: Ptger3, swissprot: PE2R3_MOUSE) Prostaglandin E2 receptor EP4 subtype (Organism: Mus musculus, class: GPCR, accessions: P32240, gene: Ptger4, swissprot: PE2R4_MOUSE) Prostaglandin E2 receptor EP2 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: Q62928, gene: Ptger2, swissprot: PE2R2_RAT) Prostaglandin E2 receptor EP4 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: P43114, gene: Ptger4, swissprot: PE2R4_RAT) Prostaglandin E2 receptor EP3 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P34980, gene: Ptger3, swissprot: PE2R3_RAT) Prostaglandin F2-alpha receptor (Organism: Mus musculus, class: GPCR, accessions: P43117, gene: Ptgfr, swissprot: PF2R_MOUSE) Prostaglandin E2 receptor EP1 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P70597, gene: Ptger1, swissprot: PE2R1_RAT) Cation channel sperm-associated protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q7RTX7, gene: CATSPER4, swissprot: CTSR4_HUMAN) Cation channel sperm-associated protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q86XQ3, gene: CATSPER3, swissprot: CTSR3_HUMAN) Cation channel sperm-associated protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NEC5, gene: CATSPER1, swissprot: CTSR1_HUMAN) Cation channel sperm-associated protein 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q96P56, gene: CATSPER2, swissprot: CTSR2_HUMAN) Prostaglandin D2 receptor 2 (Organism: Mus musculus, class: Unclassified, accessions: Q9Z2J6, gene: Ptgdr2, swissprot: PD2R2_MOUSE) | The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa. | Prostaglandin Analog (Code: N0000175454) Prostaglandins (Code: N0000007706) oxytocic (Code: CHEBI:36063) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) | 1977-08-23 FDA | 3WFH |
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| betoxycaine | None | |
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| encainide | Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM. | Anti-Arrhythmia Agents (Code: D000889) anti-arrhythmia drug (Code: CHEBI:38070) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 1987-01-01 YEAR INTRODUCED | |
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| anileridine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | minor descriptor (64-86); on line & INDEX MEDICUS search ISONIPECOTIC ACIDS (68-86); RN given refers to parent cpd | opioid receptor agonist (Code: CHEBI:60606) opioid analgesic (Code: CHEBI:35482) | None FDA | |
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| quinbolone | None | |
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| griseofulvin | Tubulin beta chain (Organism: Candida albicans, class: Structural, accessions: P10875, gene: TUB2, swissprot: TBB_CANAX) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Tubulin (Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892), class: Structural, accessions: F2SG63|F2SZ02|F2SZD3, gene: None, swissprot: F2SG63_TRIRC|F2SZ02_TRIRC|F2SZD3_TRIRC) | An antifungal agent used in the treatment of TINEA infections. | Decreased Mitosis (Code: N0000008732) Microtubule Inhibition (Code: N0000175085) Tubulin Inhibiting Agent (Code: N0000175848) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1962-08-22 FDA | |
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| acenocoumarol | Vitamin K epoxide reductase complex subunit 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BQB6, gene: VKORC1, swissprot: VKOR1_HUMAN) | A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) | anticoagulant (Code: CHEBI:50249) Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | |
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| dioxaphetyl butyrate | None | |
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| methysergide | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Induced myeloid leukemia cell differentiation protein Mcl-1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q07820, gene: MCL1, swissprot: MCL1_HUMAN) Bcl-2-like protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q07817, gene: BCL2L1, swissprot: B2CL1_HUMAN) Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) 5-hydroxytryptamine receptor 1F (Organism: Rattus norvegicus, class: Unclassified, accessions: P30940, gene: Htr1f, swissprot: 5HT1F_RAT) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) 5-hydroxytryptamine receptor 5A (Organism: Rattus norvegicus, class: Unclassified, accessions: P35364, gene: Htr5a, swissprot: 5HT5A_RAT) | An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. | sympatholytic agent (Code: CHEBI:66991) vasoconstrictor agent (Code: CHEBI:50514) serotonergic antagonist (Code: CHEBI:48279) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Vasoconstrictor Agents (Code: D014662) | 1962-02-12 FDA | |
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| motretinide | exerts a therapeutic influence on chemically induced papillomas & carcinomas of the skin in mice; RN given refers to cpd without isomeric designation; structure | |
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| acetylmethadol | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | A narcotic analgesic with a long onset and duration of action. | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| levomethadyl acetate | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | None | 1997-01-07 EMA 1993-07-09 FDA | |
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| isopropamide | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | None | 1957-10-09 FDA | |
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| butizide | 3-isobutyl analog of hydrochlorothiazide; structure | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| idoxuridine | Thymidine kinase (Organism: Cercopithecine herpesvirus 1, class: Kinase, accessions: A3RLP8, gene: UL23, swissprot: A3RLP8_CHV1) Thymidine kinase, cytosolic (Organism: Homo sapiens, class: Kinase, accessions: P04183, gene: TK1, swissprot: KITH_HUMAN) | An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent. | Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antiviral (Code: N0000175466) antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1963-06-11 FDA | 1KI7 |
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| quinfamide | None | |
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| aceclofenac | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | None FDA | |
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| sultopride | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | amino group of sulpiride on SO2 group is replaced by an ethyl group; structure; RN given refers to parent cpd | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| valganciclovir | DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) | Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of two diastereomers. After oral administration, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of human CMV in cell culture and in vivo. | Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor (Code: N0000175461) DNA Polymerase Inhibitors (Code: N0000020060) Nucleoside Analog (Code: N0000175459) prodrug (Code: CHEBI:50266) antiviral drug (Code: CHEBI:36044) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 2001-03-29 FDA | |
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| phenolsulfonphthalein | Red dye, pH indicator, and diagnostic aid for determination of renal function. It is used also for studies of the gastrointestinal and other systems. | two-colour indicator (Code: CHEBI:50412) acid-base indicator (Code: CHEBI:50407) diagnostic agent (Code: CHEBI:33295) Coloring Agents (Code: D004396) Indicators and Reagents (Code: D007202) | |
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| isofezolac | None | |
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| seratrodast | Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) | has thromboxane A2 & prostaglandin H2 receptor antagonistic action | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Peripheral Nervous System Agents (Code: D018373) Prostaglandin Antagonists (Code: D011448) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | |
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| yohimbine | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Dual specificity phosphatase Cdc25A (Organism: Homo sapiens, class: Enzyme, accessions: P30304, gene: CDC25A, swissprot: MPIP1_HUMAN) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-2A adrenergic receptor (Organism: Sus scrofa, class: GPCR, accessions: P18871, gene: ADRA2A, swissprot: ADA2A_PIG) Alpha-2 adrenergic receptor (Organism: Mus musculus, class: GPCR, accessions: P30545|Q01337|Q01338, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_MOUSE|ADA2B_MOUSE|ADA2C_MOUSE) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 1B (Organism: Mus musculus, class: Unclassified, accessions: P28334, gene: Htr1b, swissprot: 5HT1B_MOUSE) 5-hydroxytryptamine receptor 1F (Organism: Rattus norvegicus, class: Unclassified, accessions: P30940, gene: Htr1f, swissprot: 5HT1F_RAT) 5-hydroxytryptamine receptor 2B (Organism: Rattus norvegicus, class: GPCR, accessions: P30994, gene: Htr2b, swissprot: 5HT2B_RAT) | A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION. | Adrenergic Agents (Code: D018663) Adrenergic alpha-2 Receptor Antagonists (Code: D058669) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) alpha-adrenergic antagonist (Code: CHEBI:37890) serotonergic antagonist (Code: CHEBI:48279) Autonomic Agents (Code: D001337) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Urological Agents (Code: D064804) | |
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| vincamine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) | A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. | antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| hexamidine | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Urokinase-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00749, gene: PLAU, swissprot: UROK_HUMAN) Trypsin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P07477, gene: PRSS1, swissprot: TRY1_HUMAN) Suppressor of tumorigenicity 14 protein (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y5Y6, gene: ST14, swissprot: ST14_HUMAN) | None | Anti-Infective Agents (Code: D000890) antiseptic drug (Code: CHEBI:48218) | 1RPW |
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| bevonium | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| pipenzolate | None | |
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| phentetramine | None | |
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| benzilonium | None | |
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| dinoprost | Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin F2-alpha receptor (Organism: Mus musculus, class: GPCR, accessions: P43117, gene: Ptgfr, swissprot: PF2R_MOUSE) Prostaglandin F2-alpha receptor (Organism: Bos taurus, class: GPCR, accessions: P37289, gene: PTGFR, swissprot: PF2R_BOVIN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Mus musculus, class: GPCR, accessions: P30557, gene: Ptger3, swissprot: PE2R3_MOUSE) Prostaglandin E2 receptor EP3 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P34980, gene: Ptger3, swissprot: PE2R3_RAT) Prostaglandin E2 receptor EP1 subtype (Organism: Mus musculus, class: GPCR, accessions: P35375, gene: Ptger1, swissprot: PE2R1_MOUSE) Prostaglandin E2 receptor EP4 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: P43114, gene: Ptger4, swissprot: PE2R4_RAT) Prostaglandin E2 receptor EP1 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P70597, gene: Ptger1, swissprot: PE2R1_RAT) Prostaglandin E2 receptor EP2 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: Q62928, gene: Ptger2, swissprot: PE2R2_RAT) Prostaglandin D2 receptor 2 (Organism: Mus musculus, class: Unclassified, accessions: Q9Z2J6, gene: Ptgdr2, swissprot: PD2R2_MOUSE) | A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions. | Abortifacient Agents (Code: D000019) Abortifacient Agents, Nonsteroidal (Code: D000020) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) | 1976-05-18 FDA | |
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| alprostadil | Prostaglandin E2 receptor EP3 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P34980, gene: Ptger3, swissprot: PE2R3_RAT) Prostaglandin E2 receptor EP4 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: P43114, gene: Ptger4, swissprot: PE2R4_RAT) Prostacyclin receptor (Organism: Mus musculus, class: Unclassified, accessions: P43252, gene: Ptgir, swissprot: PI2R_MOUSE) Prostaglandin E2 receptor EP1 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P70597, gene: Ptger1, swissprot: PE2R1_RAT) Prostaglandin E2 receptor EP2 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: Q62928, gene: Ptger2, swissprot: PE2R2_RAT) Cation channel sperm-associated protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q7RTX7, gene: CATSPER4, swissprot: CTSR4_HUMAN) Cation channel sperm-associated protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q86XQ3, gene: CATSPER3, swissprot: CTSR3_HUMAN) Cation channel sperm-associated protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NEC5, gene: CATSPER1, swissprot: CTSR1_HUMAN) Cation channel sperm-associated protein 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q96P56, gene: CATSPER2, swissprot: CTSR2_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Mus musculus, class: GPCR, accessions: Q62053, gene: Ptger2, swissprot: PE2R2_MOUSE) Prostaglandin E2 receptor EP1 subtype (Organism: Mus musculus, class: GPCR, accessions: P35375, gene: Ptger1, swissprot: PE2R1_MOUSE) Prostaglandin E2 receptor EP3 subtype (Organism: Mus musculus, class: GPCR, accessions: P30557, gene: Ptger3, swissprot: PE2R3_MOUSE) Prostaglandin E2 receptor EP4 subtype (Organism: Mus musculus, class: GPCR, accessions: P32240, gene: Ptger4, swissprot: PE2R4_MOUSE) | A potent vasodilator agent that increases peripheral blood flow. | Genitourinary Arterial Vasodilation (Code: N0000009059) Prostaglandin Analog (Code: N0000175454) Prostaglandin E1 Agonist (Code: N0000180189) Prostaglandin Receptor Agonists (Code: N0000000106) Prostaglandins (Code: N0000007706) Venous Vasodilation (Code: N0000009911) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) Urological Agents (Code: D064804) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) platelet aggregation inhibitor (Code: CHEBI:50427) anticoagulant (Code: CHEBI:50249) | 1981-10-16 FDA | 3WHX |
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| etretinate | Retinoic acid receptor RXR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P48443, gene: RXRG, swissprot: RXRG_HUMAN) Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) | An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic. | Dermatologic Agents (Code: D003879) Keratolytic Agents (Code: D007641) keratolytic drug (Code: CHEBI:50176) | 1986-09-30 FDA | |
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| eprozinol | None | |
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| rioprostil | Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) | A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies. | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| xipamide | A sulfamoylbenzamide analog of CLOPAMIDE. It is diuretic and saluretic with antihypertensive activity. It is bound to PLASMA PROTEINS, thus has a delayed onset and prolonged action. | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| succinylsulfathiazole | intestinal antimicrobial agent; structure | |
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| moperone | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | |
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| benzomethamine | None | |
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| tinofedrine | improves cerebral and peripheral blood flow | |
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| plafibride | morpholino-methylurea analog of clofibric acid | Antimetabolites (Code: D000963) Hematologic Agents (Code: D006401) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Platelet Aggregation Inhibitors (Code: D010975) | |
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| tiaramide | NTA-194, solantal, FK 1160 refer to mono-HCl salt; RN given refers to parent cpd; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) | |
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| amodiaquine | Heparanase (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y251, gene: HPSE, swissprot: HPSE_HUMAN) Histamine N-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P50135, gene: HNMT, swissprot: HNMT_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A 4-aminoquinoline compound with anti-inflammatory properties. | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antimalarial (Code: CHEBI:38068) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) drug allergen (Code: CHEBI:88188) prodrug (Code: CHEBI:50266) | None FDA | 2AOU 4FGZ 4MWZ |
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| bithionol | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Envelope glycoprotein gp160 (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q6QLK5, gene: env, swissprot: Q6QLK5_9HIV1) M1-family alanyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8IEK1, gene: None, swissprot: Q8IEK1_PLAF7) | Halogenated anti-infective agent that is used against trematode and cestode infestations. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) antifungal agrochemical (Code: CHEBI:86328) antiplatyhelmintic drug (Code: CHEBI:35684) | 3ETD 5D0R |
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| pipobroman | An antineoplastic agent that acts by alkylation. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 1966-07-01 FDA | |
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| thiamphenicol | 50S ribosomal protein L10 (Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809), class: Ribosomal protein, accessions: P15825, gene: rpl10, swissprot: RL10_HALMA) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) | A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) immunosuppressive agent (Code: CHEBI:35705) | 2JKJ |
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| sulindac | Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Retinoic acid receptor RXR-alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P19793, gene: RXRA, swissprot: RXRA_HUMAN) Prostaglandin E synthase (Organism: Homo sapiens, class: Enzyme, accessions: O14684, gene: PTGES, swissprot: PTGES_HUMAN) Lactoylglutathione lyase (Organism: Homo sapiens, class: Enzyme, accessions: Q04760, gene: GLO1, swissprot: LGUL_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antineoplastic Agents (Code: D000970) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) antineoplastic agent (Code: CHEBI:35610) non-narcotic analgesic (Code: CHEBI:35481) analgesic (Code: CHEBI:35480) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) prodrug (Code: CHEBI:50266) tocolytic agent (Code: CHEBI:66993) | 1978-09-27 FDA | 3R7M 3RX3 3U2C 4IKJ 4IKK 4IKL 4JQ2 4WEV |
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| niaprazine | selective brain catecholamine depletor; RN given refers to parent cpd; structure | |
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| pioglitazone | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Peroxisome proliferator-activated receptor gamma (Organism: Mus musculus, class: Transcription factor, accessions: P37238, gene: Pparg, swissprot: PPARG_MOUSE) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4), class: Enzyme, accessions: Q5NGQ3, gene: fabI, swissprot: Q5NGQ3_FRATT) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Rattus norvegicus, class: Transcription factor, accessions: O88275, gene: Pparg, swissprot: PPARG_RAT) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | Pioglitazone is a thiazolidinedione that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Pioglitazone is not an insulin secretagogue. Pioglitazone is an agonist for peroxisome proliferator-activated receptor-gamma (PPAR-gamma). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. | Peroxisome Proliferator Receptor alpha Agonist (Code: N0000175596) Peroxisome Proliferator Receptor gamma Agonist (Code: N0000180186) Peroxisome Proliferator-activated Receptor Activity (Code: N0000175374) PPAR alpha (Code: N0000170118) PPAR gamma (Code: N0000170119) Thiazolidinedione (Code: N0000180190) Thiazolidinediones (Code: N0000011272) Hypoglycemic Agents (Code: D007004) insulin-sensitizing drug (Code: CHEBI:50864) | 1999-07-15 FDA | 2XKW 4A79 5Y2O |
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| hycanthone | Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Schistosomicides (Code: D012556) schistosomicide drug (Code: CHEBI:38941) | |
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| quinestradol | None | |
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| estradiol valerate | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | None | Contraceptive Agents (Code: D003270) Reproductive Control Agents (Code: D012102) | 1954-07-15 FDA | |
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| dopexamine | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Cardiovascular Agents (Code: D002317) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | 1989-01-01 YEAR INTRODUCED | |
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| tevenel | sulfamoyl analog of D-threo-chloramphenicol; structure | |
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| balsalazide | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) | a mesalamine 5-aminosalicylate prodrug; 99% of ingested drug remains intact through the stomach and is delivered to and activated in the colon; used for inflammatory bowel disease, ulcerative colitis and radiation-induced proctosigmoiditis but avoided in patients with known hypersensitivity reaction to salicylates or mesalamine | Aminosalicylate (Code: N0000175781) Aminosalicylic Acids (Code: N0000005760) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) prodrug (Code: CHEBI:50266) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) anti-ulcer drug (Code: CHEBI:49201) gastrointestinal drug (Code: CHEBI:55324) | 2000-07-18 FDA | |
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| droxicam | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) platelet aggregation inhibitor (Code: CHEBI:50427) prodrug (Code: CHEBI:50266) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) | |
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| tolrestat | Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) Aldose reductase (Organism: Sus scrofa, class: Enzyme, accessions: P80276, gene: AKR1B1, swissprot: ALDR_PIG) Aldo-keto reductase family 1 member C21 (Organism: Mus musculus, class: Enzyme, accessions: Q91WR5, gene: Akr1c21, swissprot: AK1CL_MOUSE) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Alcohol dehydrogenase [NADP(+)] (Organism: Homo sapiens, class: Enzyme, accessions: P14550, gene: AKR1A1, swissprot: AK1A1_HUMAN) Alcohol dehydrogenase [NADP(+)] (Organism: Rattus norvegicus, class: Enzyme, accessions: P51635, gene: Akr1a1, swissprot: AK1A1_RAT) Aldo-keto reductase family 1 member B10 (Organism: Homo sapiens, class: Enzyme, accessions: O60218, gene: AKR1B10, swissprot: AK1BA_HUMAN) Alcohol dehydrogenase [NADP(+)] (Organism: Sus scrofa, class: Enzyme, accessions: P50578, gene: AKR1A1, swissprot: AK1A1_PIG) | None | Enzyme Inhibitors (Code: D004791) | 1989-01-01 YEAR INTRODUCED | 1AE4 1AH3 1ZUA 2FZB 2FZD 2PDL |
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| etersalate | None | |
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| cafedrine | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| cinacalcet | Extracellular calcium-sensing receptor (Organism: Homo sapiens, class: GPCR, accessions: P41180, gene: CASR, swissprot: CASR_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES. | Calcium-sensing Receptor Agonist (Code: N0000175902) Increased Calcium-sensing Receptor Sensitivity (Code: N0000020081) Calcimimetic Agents (Code: D057966) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) calcimimetic (Code: CHEBI:48525) | 2004-10-22 EMA 2004-03-08 FDA | |
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| rosiglitazone | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Free fatty acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: O14842, gene: FFAR1, swissprot: FFAR1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Type-1A angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095, gene: Agtr1, swissprot: AGTRA_RAT) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) Short transient receptor potential channel 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UL62, gene: TRPC5, swissprot: TRPC5_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Peroxisome proliferator-activated receptor gamma (Organism: Mus musculus, class: Transcription factor, accessions: P37238, gene: Pparg, swissprot: PPARG_MOUSE) | a peroxisome proliferator-activated receptor gamma agonist; reduces lipid availability, improves insulin action & glucoregulation; Avandia is tradename for the rosiglitazone maleate | Peroxisome Proliferator Receptor gamma Agonist (Code: N0000180186) Peroxisome Proliferator-activated Receptor Activity (Code: N0000175374) PPAR gamma (Code: N0000170119) Thiazolidinedione (Code: N0000180190) Thiazolidinediones (Code: N0000011272) Hypoglycemic Agents (Code: D007004) insulin-sensitizing drug (Code: CHEBI:50864) | 1999-05-25 FDA | 1FM6 1ZGY 2PRG 3CS8 3DZY 4A7A 4EMA 4O8F 4XLD 5JI0 |
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| nalbuphine | Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. | Competitive Opioid Antagonists (Code: N0000175686) Opioid Agonist/Antagonist (Code: N0000175692) Partial Opioid Agonists (Code: N0000175685) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotic Antagonists (Code: D009292) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) opioid analgesic (Code: CHEBI:35482) | 1979-05-15 FDA | |
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| oxybutynin | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | Oxybutynin acts as a competitive antagonist of acetylcholine at post-ganglionic muscarinic receptors, resulting in relaxation of bladder smooth muscle. Oxybutynin is a racemic (50:50) mixture of R- and S-isomers. Antimuscarinic activity resides predominantly in the R-isomer. The R-isomer of oxybutynin shows greater selectivity for the M1 and M3 muscarinic subtypes (predominant in bladder detrusor muscle and parotid gland) compared to the M2 subtype (predominant in cardiac tissue). | Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Urological Agents (Code: D064804) parasympatholytic (Code: CHEBI:50370) antispasmodic drug (Code: CHEBI:53784) muscle relaxant (Code: CHEBI:51371) muscarinic antagonist (Code: CHEBI:48876) | 1975-07-16 FDA | |
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| grepafloxacin | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) DNA gyrase (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P0A4L9|P72524, gene: gyrA|gyrB, swissprot: GYRA_STRPN|GYRB_STRPN) DNA topoisomerase 4 (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P72525|Q59961, gene: parC|parE, swissprot: PARC_STRPN|PARE_STRPN) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1997-11-06 FDA | |
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| cinolazepam | None | anticonvulsant (Code: CHEBI:35623) sedative (Code: CHEBI:35717) | |
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| indomethacin | Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Interleukin-8 (Organism: Homo sapiens, class: Cytokine, accessions: P10145, gene: CXCL8, swissprot: IL8_HUMAN) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) Prostaglandin G/H synthase (cyclooxygenase) (Organism: Ovis aries, class: Enzyme, accessions: P05979|P79208, gene: PTGS1|PTGS2, swissprot: PGH1_SHEEP|PGH2_SHEEP) Prostaglandin E synthase (Organism: Homo sapiens, class: Enzyme, accessions: O14684, gene: PTGES, swissprot: PTGES_HUMAN) Aldo-keto reductase family 1 member C4 (Organism: Homo sapiens, class: Enzyme, accessions: P17516, gene: AKR1C4, swissprot: AK1C4_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Prostaglandin-H2 D-isomerase (Organism: Mus musculus, class: Enzyme, accessions: O09114, gene: Ptgds, swissprot: PTGDS_MOUSE) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) Prostaglandin G/H synthase 1 (Organism: Mus musculus, class: Enzyme, accessions: P22437, gene: Ptgs1, swissprot: PGH1_MOUSE) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) Prostaglandin G/H synthase 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355, gene: Ptgs2, swissprot: PGH2_RAT) Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) Prostaglandin G/H synthase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63921, gene: Ptgs1, swissprot: PGH1_RAT) Dehydrogenase/reductase SDR family member 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BPW9, gene: DHRS9, swissprot: DHRS9_HUMAN) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Lactoylglutathione lyase (Organism: Homo sapiens, class: Enzyme, accessions: Q04760, gene: GLO1, swissprot: LGUL_HUMAN) Nitric oxide synthase, inducible (Organism: Mus musculus, class: Enzyme, accessions: P29477, gene: Nos2, swissprot: NOS2_MOUSE) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Potassium voltage-gated channel subfamily A member 7 (Organism: Homo sapiens, class: Ion channel, accessions: Q96RP8, gene: KCNA7, swissprot: KCNA7_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cardiovascular Agents (Code: D002317) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Gout Suppressants (Code: D006074) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Sensory System Agents (Code: D018689) Tocolytic Agents (Code: D015149) analgesic (Code: CHEBI:35480) gout suppressant (Code: CHEBI:35845) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 1965-06-10 FDA | 1S2A 1Z9H 2BXK 2BXM 2BXQ 2DM6 2OTH 2ZB8 3ADS 3ADX 3FO7 3H1X 3IB1 3OGW 3UG8 3UGR 4COX 4EIX 4IK7 4IKI 4JQ4 4KYK 4XUM 4YIA |
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| clometacin | Prostaglandin-H2 D-isomerase (Organism: Mus musculus, class: Enzyme, accessions: O09114, gene: Ptgds, swissprot: PTGDS_MOUSE) | None | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| setastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | |
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| carbon tetrachloride | Cytochrome P450 2E1 (Organism: Homo sapiens, class: Enzyme, accessions: P05181, gene: CYP2E1, swissprot: CP2E1_HUMAN) | A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed) | refrigerant (Code: CHEBI:78433) | |
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| bendamustine | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) | A nitrogen mustard compound that functions as an ALKYLATING ANTINEOPLASTIC AGENT and is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA and NON-HODGKIN'S LYMPHOMA. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | 2008-03-20 FDA | |
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| prednisone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) | A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) prodrug (Code: CHEBI:50266) anti-inflammatory drug (Code: CHEBI:35472) antineoplastic agent (Code: CHEBI:35610) adrenergic agent (Code: CHEBI:37962) immunosuppressive agent (Code: CHEBI:35705) | 1955-02-21 FDA | |
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| itopride | None | |
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| cimetropium | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| cilastatin | Dipeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16444, gene: DPEP1, swissprot: DPEP1_HUMAN) Dipeptidase 1 (Organism: Sus scrofa, class: Enzyme, accessions: P22412, gene: DPEP1, swissprot: DPEP1_PIG) | A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. | Dipeptidase Inhibitors (Code: N0000175513) Renal Dehydropeptidase Inhibitor (Code: N0000175514) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1985-11-26 FDA | 1ITU |
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| dimethoxanate | None | |
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| potassium canrenoate | A synthetic pregnadiene derivative with anti-aldosterone activity. | Diuretics (Code: D004232) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoid Receptor Antagonists (Code: D000451) Natriuretic Agents (Code: D045283) | |
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| feclemine | None | |
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| etoricoxib | Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) | inhibits cyclooxygenase-2 | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 1998-01-01 YEAR INTRODUCED | 3CFL |
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| capecitabine | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) | A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER. | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) prodrug (Code: CHEBI:50266) antineoplastic agent (Code: CHEBI:35610) | 1998-04-30 FDA | |
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| adicillin | None | |
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| rabeprazole | Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) Fatty acid synthase (Organism: Homo sapiens, class: Enzyme, accessions: P49327, gene: FASN, swissprot: FAS_HUMAN) | A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | Proton Pump Inhibitor (Code: N0000175525) Anti-Ulcer Agents (Code: D000897) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Proton Pump Inhibitors (Code: D054328) anti-ulcer drug (Code: CHEBI:49201) | 1999-08-19 FDA | 3PGL |
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| cyclomethycaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | |
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| captodiame | Captodiamine represents an interesting strategy for achieving benzodiazepine substitution with a low risk of dependence or impairment of cognitive function | |
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| triclabendazole | Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) | None | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | 1990-01-01 YEAR INTRODUCED | |
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| methylclothiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) | A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825) | Increased Diuresis (Code: N0000175359) Thiazide Diuretic (Code: N0000175419) Thiazides (Code: N0000166469) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1960-10-21 FDA | |
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| nitrendipine | Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Intermediate conductance calcium-activated potassium channel protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: O15554, gene: KCNN4, swissprot: KCNN4_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) Platelet-activating factor receptor (Organism: Cavia porcellus, class: GPCR, accessions: P21556, gene: PTAFR, swissprot: PTAFR_CAVPO) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1F (Organism: Homo sapiens, class: Ion channel, accessions: O60840, gene: CACNA1F, swissprot: CAC1F_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Voltage-dependent L-type calcium channel subunit alpha-1S (Organism: Rattus norvegicus, class: Ion channel, accessions: Q02485, gene: Cacna1s, swissprot: CAC1S_RAT) | A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) | 1985-01-01 YEAR INTRODUCED | |
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| (S)-nitrendipine | Intermediate conductance calcium-activated potassium channel protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: O15554, gene: KCNN4, swissprot: KCNN4_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1F (Organism: Homo sapiens, class: Ion channel, accessions: O60840, gene: CACNA1F, swissprot: CAC1F_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Voltage-dependent L-type calcium channel subunit alpha-1S (Organism: Rattus norvegicus, class: Ion channel, accessions: Q02485, gene: Cacna1s, swissprot: CAC1S_RAT) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) | None | |
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| nadifloxacin | (R)-isomer does not induce chromosomal aberrations, unlike (S)-isomer; structure given in first source | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) | |
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| prednisolone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Glucocorticoid receptor (Organism: Mus musculus, class: Transcription factor, accessions: P06537, gene: Nr3c1, swissprot: GCR_MOUSE) Glutamine synthetase (Organism: Homo sapiens, class: Enzyme, accessions: P15104, gene: GLUL, swissprot: GLNA_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) Interleukin-6 (Organism: Homo sapiens, class: Cytokine, accessions: P05231, gene: IL6, swissprot: IL6_HUMAN) Disintegrin and metalloproteinase domain-containing protein 17 (Organism: Homo sapiens, class: Unclassified, accessions: P78536, gene: ADAM17, swissprot: ADA17_HUMAN) | A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) adrenergic agent (Code: CHEBI:37962) anti-inflammatory drug (Code: CHEBI:35472) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) | 1955-06-21 FDA | |
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| cortisone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Potassium voltage-gated channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q09470, gene: KCNA1, swissprot: KCNA1_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Protein farnesyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P49354|P49356, gene: FNTA|FNTB, swissprot: FNTA_HUMAN|FNTB_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) | Anti-Inflammatory Agents (Code: D000893) | 1950-06-13 FDA | |
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| aldosterone | Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Mineralocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P22199, gene: Nr3c2, swissprot: MCR_RAT) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. | 2AA2 2Q1H |
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| tetrachloroethylene | A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen. | Carcinogens (Code: D002273) Environmental Pollutants (Code: D004785) Noxae (Code: D009676) Solvents (Code: D012997) | |
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| scopolamine butylbromide | Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract. | 1951-01-01 YEAR INTRODUCED | |
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| iloprost | Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Mus musculus, class: GPCR, accessions: P30557, gene: Ptger3, swissprot: PE2R3_MOUSE) Prostaglandin E2 receptor EP4 subtype (Organism: Mus musculus, class: GPCR, accessions: P32240, gene: Ptger4, swissprot: PE2R4_MOUSE) Prostaglandin E2 receptor EP3 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P34980, gene: Ptger3, swissprot: PE2R3_RAT) Prostaglandin E2 receptor EP1 subtype (Organism: Mus musculus, class: GPCR, accessions: P35375, gene: Ptger1, swissprot: PE2R1_MOUSE) Prostacyclin receptor (Organism: Mus musculus, class: Unclassified, accessions: P43252, gene: Ptgir, swissprot: PI2R_MOUSE) Prostaglandin E2 receptor EP1 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P70597, gene: Ptger1, swissprot: PE2R1_RAT) Prostaglandin E2 receptor EP2 subtype (Organism: Mus musculus, class: GPCR, accessions: Q62053, gene: Ptger2, swissprot: PE2R2_MOUSE) Prostaglandin E2 receptor EP2 subtype (Organism: Rattus norvegicus, class: GPCR, accessions: Q62928, gene: Ptger2, swissprot: PE2R2_RAT) | An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation. | Prostacycline (Code: N0000175603) Prostaglandins I (Code: N0000011280) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) Vasodilator Agents (Code: D014665) platelet aggregation inhibitor (Code: CHEBI:50427) vasodilator agent (Code: CHEBI:35620) | 2004-12-29 FDA | 3SP6 3SP9 |
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| drostanolone propionate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | synthetic anabolic androgenic steroid used to lower plasma cholesterol & as antineoplastic agent in advanced breast neoplasms; major descriptor (66-86); on-line search ANDROSTANOLS (80-86); ANDROSTANES (68-86); INDEX MEDICUS search DROMOSTANOLONE (66-86); RN given refers to (2alpha,5alpha,17beta)-isomer | antineoplastic agent (Code: CHEBI:35610) | None FDA | |
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| ethyl loflazepate | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| fenofibrate | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) | An antilipemic agent which reduces both CHOLESTEROL and TRIGLYCERIDES in the blood. | Peroxisome Proliferator Receptor alpha Agonist (Code: N0000175596) Peroxisome Proliferator-activated Receptor alpha Agonists (Code: N0000175375) PPAR alpha (Code: N0000170118) Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) antilipemic drug (Code: CHEBI:35679) | 1993-12-31 FDA | |
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| haletazole | None | |
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| ofloxacin | DNA gyrase subunit B (Organism: Escherichia coli O157:H7, class: Enzyme, accessions: P0AES7, gene: gyrB, swissprot: GYRB_ECO57) Gag-Pro-Pol polyprotein (Organism: Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A), class: Polyprotein, accessions: P03362, gene: gag-pro-pol, swissprot: POL_HTL1A) DNA gyrase subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4, gene: gyrA, swissprot: GYRA_ECOLI) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47869, gene: GABRA2, swissprot: GBRA2_HUMAN) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Trypsin (Organism: Sus scrofa, class: Unclassified, accessions: P00761, gene: None, swissprot: TRYP_PIG) CAAX prenyl protease 1 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: P47154, gene: STE24, swissprot: STE24_YEAST) | A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antineoplastic Agents (Code: D000970) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Renal Agents (Code: D012076) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antiinfective agent (Code: CHEBI:35441) antibacterial drug (Code: CHEBI:36047) | 1990-12-28 FDA | 2BML 3K9F 3RAE 4JUO 4Z2D 5BTG 5BTI 5EIX |
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| levofloxacin | DNA gyrase subunit A (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WG47, gene: gyrA, swissprot: GYRA_MYCTU) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) DNA gyrase (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P0A4L9|P72524, gene: gyrA|gyrB, swissprot: GYRA_STRPN|GYRB_STRPN) DNA topoisomerase 4 (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P72525|Q59961, gene: parC|parE, swissprot: PARC_STRPN|PARE_STRPN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) CAAX prenyl protease 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y256, gene: RCE1, swissprot: FACE2_HUMAN) | The L-isomer of Ofloxacin. | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antineoplastic Agents (Code: D000970) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Renal Agents (Code: D012076) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) | 1996-12-20 FDA | 3K9F 3RAE 4JUO 4Z2D 5BTG 5BTI 5EIX |
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| bisacodyl | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) | A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871) | Increased Large Intestinal Motility (Code: N0000009371) Stimulant Laxative (Code: N0000175812) Stimulation Large Intestine Fluid/Electrolyte Secretion (Code: N0000009871) Cathartics (Code: D002400) Gastrointestinal Agents (Code: D005765) Laxatives (Code: D054368) | 2004-05-10 FDA | |
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| haloprogin | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) UDP-glucose 4-epimerase (Organism: Homo sapiens, class: Enzyme, accessions: Q14376, gene: GALE, swissprot: GALE_HUMAN) | minor descriptor (73-86); on-line & INDEX MEDICUS search PHENYL ETHERS (73-86) | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | None FDA | |
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| metampicillin | None | |
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| carbocromen | A coronary vasodilator agent. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| octocrylene | ingredient in sunscreens and cosmetics | 2006-07-21 FDA | |
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| prenoxdiazine | None | |
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| bezafibrate | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Lipoprotein lipase (Organism: Homo sapiens, class: Enzyme, accessions: P06858, gene: LPL, swissprot: LIPL_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Fatty acid-binding protein, intestinal (Organism: Homo sapiens, class: Cytosolic other, accessions: P12104, gene: FABP2, swissprot: FABPI_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) | An antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW DENSITY LIPOPROTEINS and increases HIGH DENSITY LIPOPROTEINS. | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) antilipemic drug (Code: CHEBI:35679) | 1978-01-01 YEAR INTRODUCED | 1IWH 5X2S 5X2T |
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| fosphenytoin | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | None | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 1996-08-05 FDA | |
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| phthalylsulfacetamide | None | |
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| protirelin | Thyrotropin-releasing hormone receptor (Organism: Mus musculus, class: GPCR, accessions: P21761, gene: Trhr, swissprot: TRFR_MOUSE) Thyrotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P34981, gene: TRHR, swissprot: TRFR_HUMAN) Protein Trhr2; Thyrotropin releasing hormone receptor 2; Thyrotropin-releasing hormone receptor 2 (Organism: Rattus norvegicus, class: GPCR, accessions: Q9R297, gene: Trhr2, swissprot: Q9R297_RAT) Thyrotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q01717, gene: Trhr, swissprot: TRFR_RAT) Thyrotropin-releasing hormone receptor 2 (Organism: Mus musculus, class: Unclassified, accessions: Q9ERT1, gene: TRH-R2, swissprot: Q9ERT1_MOUSE) | None | 1976-11-05 FDA | |
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| piretanide | Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) Solute carrier family 12 member 2 (Organism: Homo sapiens, class: Transporter, accessions: P55011, gene: SLC12A2, swissprot: S12A2_HUMAN) | potent inhibitor of chloride transport; structure | Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Potassium Chloride Symporter Inhibitors (Code: D049994) | 1980-01-01 YEAR INTRODUCED | |
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| revaprazan | Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) | proton pump inhibitor | 2005-09-15 Korean Food and Drug Administration (KFDA) | |
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| hydrocortisone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Nitric oxide synthase, inducible (Organism: Homo sapiens, class: Enzyme, accessions: P35228, gene: NOS2, swissprot: NOS2_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Glucocorticoid receptor (Organism: Mus musculus, class: Transcription factor, accessions: P06537, gene: Nr3c1, swissprot: GCR_MOUSE) | The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Inflammatory Agents (Code: D000893) anti-inflammatory drug (Code: CHEBI:35472) anti-allergic agent (Code: CHEBI:50857) anti-asthmatic drug (Code: CHEBI:49167) | 1952-08-05 FDA | 2V95 2VDY 4C49 4P6X 5HGC |
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| solifenacin | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | A quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE. | Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) | 2004-11-19 FDA | |
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| dexetimide | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor (Organism: Mus musculus, class: GPCR, accessions: P12657|P32211|Q920H4|Q9ERZ3|Q9ERZ4, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_MOUSE|ACM2_MOUSE|ACM3_MOUSE|ACM4_MOUSE|ACM5_MOUSE) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) | A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide. | Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| viminol | proposed as antitussive or analgesic; occurs as six stereoisomer with differing action; minor descriptor (75-86); on-line & INDEX MEDICUS search ETHANOLAMINES (75-86); RN given refers to parent cpd without isomeric designation | |
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| mexazolam | None | |
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| cefadroxil | Solute carrier family 15 member 1 (Organism: Homo sapiens, class: Transporter, accessions: P46059, gene: SLC15A1, swissprot: S15A1_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1978-02-17 FDA | |
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| rufloxacin | None | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| talinolol | Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| opipramol | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) | A tricyclic antidepressant with actions similar to AMITRIPTYLINE. | Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) | |
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| lapyrium chloride | None | None FDA | |
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| etofibrate | analog of clofibrate with nicotinic acid substituted on the 2-carbon of the ethyl ester group; structure; RN given refers to parent cpd | Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| diaziquone | None | Antineoplastic Agents (Code: D000970) Cross-Linking Reagents (Code: D003432) Indicators and Reagents (Code: D007202) antineoplastic agent (Code: CHEBI:35610) | |
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| pheneticillin | pheneticillin (feneticillin) is an oral acid resistant penicillin analogous to penicillin V with a range of antimicrob activity similar to penicillin G | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| bumetanide | Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) Solute carrier family 12 member 2 (Organism: Homo sapiens, class: Transporter, accessions: P55011, gene: SLC12A2, swissprot: S12A2_HUMAN) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) | A sulfamyl diuretic. | Increased Diuresis at Loop of Henle (Code: N0000175366) Loop Diuretic (Code: N0000175590) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Potassium Chloride Symporter Inhibitors (Code: D049994) diuretic (Code: CHEBI:35498) | 1983-02-28 FDA | |
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| cyclofenil | A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE. | Fertility Agents (Code: D005299) Fertility Agents, Female (Code: D005300) Reproductive Control Agents (Code: D012102) | |
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| piminodine | None | |
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| tribuzone | antirheumatic, anti-inflammatory agent with analgesic properties; minor descriptor (75-85); on-line search PHENYLBUTAZONE/AA (75-85); Index Medicus search PYRAZOLES (75-80), PHENYLBUTAZONE/AA (81-85) | |
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| quinestrol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | The 3-cyclopentyl ether of ETHINYL ESTRADIOL. After gastrointestinal absorption, it is stored in ADIPOSE TISSUE, slowly released, and metabolized principally to the parent compound. It has been used in ESTROGEN REPLACEMENT THERAPY. (From AMA Drug Evaluations Annual, 1992, p1011) | Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) xenoestrogen (Code: CHEBI:76988) | None FDA | |
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| benzoxonium chloride | None | |
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| suclofenide | None | |
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| clostebol acetate | None | |
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| fludarabine phosphate | DNA polymerase alpha catalytic subunit (Organism: Homo sapiens, class: Enzyme, accessions: P09884, gene: POLA1, swissprot: DPOLA_HUMAN) Ribonucleoside-diphosphate reductase subunit M2 (Organism: Homo sapiens, class: Enzyme, accessions: P31350, gene: RRM2, swissprot: RIR2_HUMAN) Ribonucleoside-diphosphate reductase large subunit (Organism: Homo sapiens, class: Enzyme, accessions: P23921, gene: RRM1, swissprot: RIR1_HUMAN) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Adenosine receptor A3 (Organism: Rattus norvegicus, class: GPCR, accessions: P28647, gene: Adora3, swissprot: AA3R_RAT) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) | None | Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) prodrug (Code: CHEBI:50266) | 1991-04-18 FDA | |
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| clofoctol | None | |
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| cefroxadine | orally active, broad spectrum cephalosporin | |
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| amoxicillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1974-12-09 FDA | |
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| alkofanone | None | |
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| caroverine | None | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) | |
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| periciazine | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) | None | adrenergic antagonist (Code: CHEBI:37887) sedative (Code: CHEBI:35717) first generation antipsychotic (Code: CHEBI:65190) | |
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| trimetaphan | Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Neuronal acetylcholine receptor subunit alpha-10 (Organism: Homo sapiens, class: Ion channel, accessions: Q9GZZ6, gene: CHRNA10, swissprot: ACH10_HUMAN) Nicotinic acetylcholine receptor alpha 5 subunit (Organism: Musca domestica, class: Ion channel, accessions: A9XFY4, gene: nAChRalpha5, swissprot: A9XFY4_MUSDO) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. | Adjuvants, Anesthesia (Code: D000759) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) Vasodilator Agents (Code: D014665) anaesthesia adjuvant (Code: CHEBI:60807) vasodilator agent (Code: CHEBI:35620) antihypertensive agent (Code: CHEBI:35674) nicotinic antagonist (Code: CHEBI:48878) | None FDA | |
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| clinafloxacin | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 3FOE 3RAD |
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| propiverine | anticholinergic used for overactive bladder syndrome | Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Urological Agents (Code: D064804) | |
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| metolazone | Solute carrier family 12 member 1 (Organism: Homo sapiens, class: Transporter, accessions: Q13621, gene: SLC12A1, swissprot: S12A1_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) | Metolazone is a quinazoline diuretic, with properties generally similar to the thiazide diuretics. The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Metolazone acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Metolazone does not inhibit carbonic anhydrase. A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. This action has been demonstrated in animals by micropuncture studies. | Increased Diuresis (Code: N0000175359) Thiazide-like Diuretic (Code: N0000175420) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) | 1973-11-27 FDA | |
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| indapamide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Potassium voltage-gated channel subfamily KQT member 1 (Organism: Homo sapiens, class: Ion channel, accessions: P51787, gene: KCNQ1, swissprot: KCNQ1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) | A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS. | Increased Diuresis (Code: N0000175359) Thiazide-like Diuretic (Code: N0000175420) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) antihypertensive agent (Code: CHEBI:35674) diuretic (Code: CHEBI:35498) | 1983-07-06 FDA | 3BL1 |
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| cyclovalone | Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) | is a synthetic curcumin derivative | |
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| ilaprazole | Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) | None | 2008-10-28 Korean Food and Drug Administration (KFDA) | |
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| glibornuride | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) | was MH 1975-92 (see under SULFONYLUREA COMPOUNDS 1975-90); use SULFONYLUREA COMPOUNDS to search GLIBORNURIDE 1975-92; an oral, sulfonylurea hypoglycemic agent which stimulates insulin secretion | Hypoglycemic Agents (Code: D007004) | 1969-01-01 YEAR INTRODUCED | |
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| drospirenone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | a progestational compound with antimineralocorticoid and antiandrogenic activity; structure given in first source | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Diuretics (Code: D004232) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoid Receptor Antagonists (Code: D000451) Natriuretic Agents (Code: D045283) contraceptive drug (Code: CHEBI:49323) | 2001-05-11 FDA | |
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| bepridil | Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Organism: Homo sapiens, class: Ion channel, accessions: O00555, gene: CACNA1A, swissprot: CAC1A_HUMAN) Potassium voltage-gated channel subfamily KQT member 4 (Organism: Homo sapiens, class: Ion channel, accessions: P56696, gene: KCNQ4, swissprot: KCNQ4_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Oryctolagus cuniculus, class: Ion channel, accessions: P15381, gene: CACNA1C, swissprot: CAC1C_RABIT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Lethal factor (Organism: Bacillus anthracis, class: Enzyme, accessions: P15917, gene: lef, swissprot: LEF_BACAN) | A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. | Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) anti-arrhythmia drug (Code: CHEBI:38070) antihypertensive agent (Code: CHEBI:35674) | 1990-12-28 FDA | 1DTL 6F5U |
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| phenoperidine | A narcotic analgesic partly metabolized to meperidine in the liver. It is similar to morphine in action and used for neuroleptanalgesia, usually with droperidol. | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| atovaquone | Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial (Organism: Euglena gracilis, class: Enzyme, accessions: P43264, gene: None, swissprot: QCR1_EUGGR) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q02127, gene: DHODH, swissprot: PYRD_HUMAN) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63707, gene: Dhodh, swissprot: PYRD_RAT) Cytochrome b (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q02768, gene: MT-CYB, swissprot: CYB_PLAFA) | A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. | Antiprotozoal (Code: N0000175485) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) antimalarial (Code: CHEBI:38068) | 1992-11-25 FDA | 4PD4 |
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| pitofenone | None | |
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| dioxyline | Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) Methionine aminopeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P53582, gene: METAP1, swissprot: MAP11_HUMAN) | None | |
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| bambuterol | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) | selective inhibitor of butyrylcholinesterase & acetylcholinesterase | Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) tocolytic agent (Code: CHEBI:66993) sympathomimetic agent (Code: CHEBI:35524) beta-adrenergic agonist (Code: CHEBI:35522) prodrug (Code: CHEBI:50266) bronchodilator agent (Code: CHEBI:35523) anti-asthmatic drug (Code: CHEBI:49167) | 1990-01-01 YEAR INTRODUCED | |
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| tiracizine | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| fenbutrazate | None | |
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| blonanserin | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | None | 2008-01-25 PMDA | |
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| cefaclor | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) drug allergen (Code: CHEBI:88188) | 1979-04-04 FDA | |
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| prucalopride | 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) | a 5-HT4 agonist enterokinetic compound | Gastrointestinal Agents (Code: D005765) Laxatives (Code: D054368) Neurotransmitter Agents (Code: D018377) Serotonin 5-HT4 Receptor Agonists (Code: D058828) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 2009-10-15 EMA | |
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| diacerein | Caspase-3 (Organism: Homo sapiens, class: Enzyme, accessions: P42574, gene: CASP3, swissprot: CASP3_HUMAN) Caspase-7 (Organism: Homo sapiens, class: Enzyme, accessions: P55210, gene: CASP7, swissprot: CASP7_HUMAN) Female germline-specific tumor suppressor gld-1 (Organism: Caenorhabditis elegans, class: Unclassified, accessions: Q17339, gene: gld-1, swissprot: GLD1_CAEEL) | chelates with bivalent metals; a quinone which possesses redox properties; metabolized to active rhein; proposed mechanisms include inhibiting IL1 and metalloproteinases; called a slow acting symptomatic drug in osteoarthritis; no effect of cyclooxygenase | Anti-Inflammatory Agents (Code: D000893) | |
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| cyclarbamate | None | |
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| perindopril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure. | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) antihypertensive agent (Code: CHEBI:35674) | 1993-12-30 FDA | |
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| etofenamate | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| pyritinol | A neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity. | |
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| prasterone sulfate | The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. | |
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| propantheline | Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Anticholinergic (Code: N0000175574) Anti-Ulcer Agents (Code: D000897) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Gastrointestinal Agents (Code: D005765) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | 1953-04-02 FDA | |
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| carboprost | Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) | A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY. | Prostaglandin Analog (Code: N0000175454) Prostaglandins (Code: N0000007706) Abortifacient Agents (Code: D000019) Abortifacient Agents, Nonsteroidal (Code: D000020) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) oxytocic (Code: CHEBI:36063) abortifacient (Code: CHEBI:50691) | 1979-01-09 FDA | |
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| cinnarizine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS. | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) antiemetic (Code: CHEBI:50919) histamine antagonist (Code: CHEBI:37956) muscarinic antagonist (Code: CHEBI:48876) anti-allergic agent (Code: CHEBI:50857) H1-receptor antagonist (Code: CHEBI:37955) | |
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| cethexonium | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Surface-Active Agents (Code: D013501) | |
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| ketazolam | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| fleroxacin | DNA gyrase subunit A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4, gene: gyrA, swissprot: GYRA_ECOLI) | A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE. | Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) | 1992-01-01 YEAR INTRODUCED | |
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| lansoprazole | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Microtubule-associated protein tau (Organism: Homo sapiens, class: Structural, accessions: P10636, gene: MAPT, swissprot: TAU_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) Phosphoethanolamine/phosphocholine phosphatase (Organism: Homo sapiens, class: Enzyme, accessions: Q8TCT1, gene: PHOSPHO1, swissprot: PHOP1_HUMAN) Fatty acid synthase (Organism: Homo sapiens, class: Enzyme, accessions: P49327, gene: FASN, swissprot: FAS_HUMAN) | A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. | Proton Pump Inhibitor (Code: N0000175525) Inhibition Gastric Acid Secretion (Code: N0000009724) Anti-Ulcer Agents (Code: D000897) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Proton Pump Inhibitors (Code: D054328) anti-ulcer drug (Code: CHEBI:49201) | 1995-05-10 FDA | |
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| sulfadiasulfone | None | |
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| trimetrexate | Folylpolyglutamate synthase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q05932, gene: FPGS, swissprot: FOLC_HUMAN) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Dihydrofolate reductase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0ABQ4, gene: folA, swissprot: DYR_ECOLI) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Dihydrofolate reductase (Organism: Mus musculus, class: Enzyme, accessions: P00375, gene: Dhfr, swissprot: DYR_MOUSE) Dihydrofolate reductase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P07807, gene: DFR1, swissprot: DYR_YEAST) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: Q27793, gene: None, swissprot: DRTS_TRYCR) Dihydrofolate reductase (Organism: Candida albicans, class: Enzyme, accessions: P22906, gene: DFR1, swissprot: DYR_CANAX) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) Dihydrofolate reductase (Organism: Mycobacterium avium, class: Enzyme, accessions: O30463, gene: folA, swissprot: O30463_MYCAV) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) Noxae (Code: D009676) antifungal drug (Code: CHEBI:86327) | 1993-12-17 FDA | 2X9V 3CLB 3HBB 4M2X 4XT8 |
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| bulaquine | None | |
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| cilostazol | cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Organism: Homo sapiens, class: Enzyme, accessions: Q13370, gene: PDE3B, swissprot: PDE3B_HUMAN) | None | Phosphodiesterase 3 Inhibitor (Code: N0000175598) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Neuroprotective Agents (Code: D018696) Peripheral Nervous System Agents (Code: D018373) Phosphodiesterase 3 Inhibitors (Code: D058987) Phosphodiesterase Inhibitors (Code: D010726) Platelet Aggregation Inhibitors (Code: D010975) Protective Agents (Code: D020011) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) anticoagulant (Code: CHEBI:50249) neuroprotective agent (Code: CHEBI:63726) bronchodilator agent (Code: CHEBI:35523) vasodilator agent (Code: CHEBI:35620) fibrin modulating drug (Code: CHEBI:48676) platelet aggregation inhibitor (Code: CHEBI:50427) | 1999-01-15 FDA | |
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| amisulpride | D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | None | second generation antipsychotic (Code: CHEBI:65191) | 1986-01-01 YEAR INTRODUCED | |
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| norgestimate | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | None | Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) contraceptive drug (Code: CHEBI:49323) synthetic oral contraceptive (Code: CHEBI:49326) | 1989-12-29 FDA | |
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| diprafenone | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| prajmalium | A derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| tripamide | None | Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Potassium Chloride Symporter Inhibitors (Code: D049994) | |
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| flavodic acid | capillary protective agent; RN given refers to parent cpd; structure | |
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| parecoxib | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | Parecoxib is a prodrug of valdecoxib. Valdecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor within the clinical dose range. Cyclooxygenase is responsible for generation of prostaglandins. Two isoforms, COX-1 and COX-2, have been identified. COX-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) prodrug (Code: CHEBI:50266) | 2002-03-22 EMA | 2ZMB |
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| thioridazine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Serine/threonine-protein kinase pim-1 (Organism: Homo sapiens, class: Kinase, accessions: P11309, gene: PIM1, swissprot: PIM1_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) | A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) first generation antipsychotic (Code: CHEBI:65190) serotonergic antagonist (Code: CHEBI:48279) H1-receptor antagonist (Code: CHEBI:37955) alpha-adrenergic antagonist (Code: CHEBI:37890) dopaminergic antagonist (Code: CHEBI:48561) | 1962-03-15 FDA | 3TBG 4I1R 4IAA 4UHX 4WNW |
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| fusidic acid | Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1Q23 1QCA 2VUF 4V5F 4V8U 4V9L 4V9M 4W29 4WQF 5JMN |
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| hydroxyestrone diacetate | None | |
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| elcometrine | None | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Reproductive Control Agents (Code: D012102) | |
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| nomegestrol acetate | None | 2011-07-27 EMA | |
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| oxypendyl | None | |
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| rimexolone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1994-12-30 FDA | |
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| penmesterol | None | |
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| rebamipide | Cholecystokinin receptor type A (Organism: Rattus norvegicus, class: GPCR, accessions: P30551, gene: Cckar, swissprot: CCKAR_RAT) | Rebamipide is a mucosal protective agent and is postulated to increase gastric blood flow, prostaglandin biosynthesis and decrease free oxygen radicals. | Anti-Ulcer Agents (Code: D000897) Antioxidants (Code: D000975) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Protective Agents (Code: D020011) | 2011-09-26 PMDA | |
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| azosemide | None | Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) loop diuretic (Code: CHEBI:77608) | |
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| lorcainide | Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| remoxipride | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Chlorocebus aethiops, class: GPCR, accessions: P52703, gene: DRD3, swissprot: DRD3_CHLAE) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(2) dopamine receptor (Organism: Chlorocebus aethiops, class: GPCR, accessions: P52702, gene: DRD2, swissprot: DRD2_CHLAE) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1990-01-01 YEAR INTRODUCED | |
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| azaribine | pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides | Dermatologic Agents (Code: D003879) antipsoriatic (Code: CHEBI:50748) prodrug (Code: CHEBI:50266) | |
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| nedocromil | G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) | A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. | Decreased Histamine Release (Code: N0000175628) Mast Cell Stabilizer (Code: N0000175630) Anti-Allergic Agents (Code: D018926) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Respiratory System Agents (Code: D019141) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) anti-asthmatic drug (Code: CHEBI:49167) anti-allergic agent (Code: CHEBI:50857) | 1992-12-30 FDA | |
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| isradipine | Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Oryctolagus cuniculus, class: Ion channel, accessions: P15381, gene: CACNA1C, swissprot: CAC1C_RABIT) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Rattus norvegicus, class: Ion channel, accessions: P27732, gene: Cacna1d, swissprot: CAC1D_RAT) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Mus musculus, class: Ion channel, accessions: Q01815, gene: Cacna1c, swissprot: CAC1C_MOUSE) Voltage-dependent L-type calcium channel subunit alpha-1F (Organism: Mus musculus, class: Unclassified, accessions: Q9JIS7, gene: Cacna1f, swissprot: CAC1F_MOUSE) | A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure. | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) | 1990-12-20 FDA | |
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| amocarzine | None | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Filaricides (Code: D005369) antinematodal drug (Code: CHEBI:35444) | |
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| tamoxifen | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) B2 bradykinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30411, gene: BDKRB2, swissprot: BKRB2_HUMAN) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Organism: Homo sapiens, class: Enzyme, accessions: Q08209, gene: PPP3CA, swissprot: PP2BA_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Estrogen-related receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P62508, gene: ESRRG, swissprot: ERR3_HUMAN) G-protein coupled estrogen receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q99527, gene: GPER1, swissprot: GPER1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Emopamil-binding protein-like (Organism: Homo sapiens, class: Unclassified, accessions: Q9BY08, gene: EBPL, swissprot: EBPL_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Transcriptional activator protein luxR (Organism: Aliivibrio fischeri, class: Unclassified, accessions: P12746, gene: luxR, swissprot: LUXR_ALIFS) Steroid hormone receptor ERR1 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11474, gene: ESRRA, swissprot: ERR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Anti-estrogen binding site (AEBS) (Organism: Homo sapiens, class: Enzyme, accessions: Q15125|Q9UBM7, gene: DHCR7|EBP, swissprot: DHCR7_HUMAN|EBP_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. | Estrogen Agonist/Antagonist (Code: N0000175826) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Bone Density Conservation Agents (Code: D050071) Estrogen Antagonists (Code: D004965) Estrogen Receptor Modulators (Code: D020847) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Selective Estrogen Receptor Modulators (Code: D020845) estrogen antagonist (Code: CHEBI:50837) estrogen receptor modulator (Code: CHEBI:50739) bone density conservation agent (Code: CHEBI:50646) estrogen receptor antagonist (Code: CHEBI:50792) angiogenesis inhibitor (Code: CHEBI:48422) antineoplastic agent (Code: CHEBI:35610) | 1977-12-30 FDA | 1YA4 |
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| arotinolol | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | |
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| camazepam | None | |
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| lornoxicam | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) | |
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| trazodone | Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309) | Serotonin Reuptake Inhibitor (Code: N0000175696) Anti-Anxiety Agents (Code: D014151) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Uptake Inhibitors (Code: D017367) Tranquilizing Agents (Code: D014149) antidepressant (Code: CHEBI:35469) sedative (Code: CHEBI:35717) adrenergic antagonist (Code: CHEBI:37887) H1-receptor antagonist (Code: CHEBI:37955) serotonin uptake inhibitor (Code: CHEBI:50949) anxiolytic drug (Code: CHEBI:35474) | 1981-12-24 FDA | |
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| exisulind | Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) | inhibits K-ras-dependent cyclooxygenase-2; sulfated analog of indomethacin;; CP248 is an antineoplastic agent that fosters microtubule depolymerization | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sensory System Agents (Code: D018689) | 3RX2 |
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| medroxalol | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| aminoquinuride | Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Botulinum neurotoxin type A (Organism: Clostridium botulinum, class: Enzyme, accessions: P10845, gene: botA, swissprot: BXA1_CLOBO) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) Lethal factor (Organism: Bacillus anthracis, class: Enzyme, accessions: P15917, gene: lef, swissprot: LEF_BACAN) | None | 1PWP 5CUQ |
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| prednylidene | None | |
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| meprednisone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1978-01-26 FDA | |
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| desoxycorticosterone acetate | Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) | The 21-acetate derivative of desoxycorticosterone. | Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoids (Code: D008901) | 1939-08-17 FDA | |
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| nabilone | Cannabinoid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P34972, gene: CNR2, swissprot: CNR2_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Cannabinoid receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: P20272, gene: Cnr1, swissprot: CNR1_RAT) Cannabinoid receptor 2 (Organism: Mus musculus, class: GPCR, accessions: P47936, gene: Cnr2, swissprot: CNR2_MOUSE) | cannabinol deriv; RN given refers to cpd without isomeric designation; structure | Cannabinoid (Code: N0000175782) Cannabinoids (Code: N0000008010) Anti-Anxiety Agents (Code: D014151) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1985-12-26 FDA | |
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| anagestone acetate | None | |
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| finasteride | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P31213, gene: SRD5A2, swissprot: S5A2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18405, gene: SRD5A1, swissprot: S5A1_HUMAN) 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P24008, gene: Srd5a1, swissprot: S5A1_RAT) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P31214, gene: Srd5a2, swissprot: S5A2_RAT) Steroid 5-alpha-reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P24008|P31214, gene: Srd5a1|Srd5a2, swissprot: S5A1_RAT|S5A2_RAT) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14060, gene: HSD3B1, swissprot: 3BHS1_HUMAN) | An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA. | 5-alpha Reductase Inhibitor (Code: N0000175836) 5-alpha Reductase Inhibitors (Code: D058891) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) Urological Agents (Code: D064804) antihyperplasia drug (Code: CHEBI:59844) androgen antagonist (Code: CHEBI:35497) | 1992-06-19 FDA | 3G1R |
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| oxametacin | Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) | |
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| glafenine | Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | An anthranilic acid derivative with analgesic properties used for the relief of all types of pain. | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | |
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| deferasirox | iron (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) | for the treatment of chronic iron overload from blood transfusions | Iron Chelating Activity (Code: N0000000144) Iron Chelator (Code: N0000175522) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Cytochrome P450 1A2 Inhibitors (Code: N0000182138) Chelating Agents (Code: D002614) Iron Chelating Agents (Code: D007502) Sequestering Agents (Code: D064449) | 2005-11-02 FDA | |
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| prasugrel | P2Y purinoceptor 12 (Organism: Homo sapiens, class: GPCR, accessions: Q9H244, gene: P2RY12, swissprot: P2Y12_HUMAN) | A piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS. | Decreased Platelet Aggregation (Code: N0000008832) P2Y12 Platelet Inhibitor (Code: N0000182142) P2Y12 Receptor Antagonists (Code: N0000182143) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) platelet glycoprotein-IIb/IIIa receptor antagonist (Code: CHEBI:50433) cardiovascular drug (Code: CHEBI:35554) prodrug (Code: CHEBI:50266) | 2009-07-10 FDA | |
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| bunazosin | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Neurotransmitter Agents (Code: D018377) | |
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| clebopride | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: Q62758, gene: Htr4, swissprot: 5HT4R_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | antidopaminergic; RN given refers to parent cpd; structure | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) | |
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| prochlorperazine | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612) | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) antiemetic (Code: CHEBI:50919) dopaminergic antagonist (Code: CHEBI:48561) alpha-adrenergic antagonist (Code: CHEBI:37890) cholinergic antagonist (Code: CHEBI:48873) first generation antipsychotic (Code: CHEBI:65190) | 1956-10-23 FDA | 3M0W |
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| trospectomycin | active against Neisseria gonorrhoeae; RN refers to 2R-(2alpha,4abeta,5abeta,6beta,7beta,8beta,9beta,9alpha,9aalpha,10abeta)-(9CI)-isomer | |
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| methylprednisolone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) | A PREDNISOLONE derivative with similar anti-inflammatory action. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Neuroprotective Agents (Code: D018696) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) anti-inflammatory drug (Code: CHEBI:35472) neuroprotective agent (Code: CHEBI:63726) adrenergic agent (Code: CHEBI:37962) antiemetic (Code: CHEBI:50919) | 1957-10-24 FDA | |
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| cicaprost | Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Mus musculus, class: GPCR, accessions: P30557, gene: Ptger3, swissprot: PE2R3_MOUSE) Prostacyclin receptor (Organism: Mus musculus, class: Unclassified, accessions: P43252, gene: Ptgir, swissprot: PI2R_MOUSE) Prostaglandin E2 receptor EP2 subtype (Organism: Mus musculus, class: GPCR, accessions: Q62053, gene: Ptger2, swissprot: PE2R2_MOUSE) | None | Antineoplastic Agents (Code: D000970) | |
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| artisone acetate | None | |
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| cyproterone acetate | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) | An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites. | Androgen Antagonists (Code: D000726) Antineoplastic Agents (Code: D000970) Contraceptive Agents (Code: D003270) Contraceptive Agents, Male (Code: D003272) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) androgen antagonist (Code: CHEBI:35497) | 1974-01-01 YEAR INTRODUCED | 2OZ7 |
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| bromhexine | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) | A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744) | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) mucolytic (Code: CHEBI:77034) | |
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| hydroxyzine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Envelope glycoprotein gp160 (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q6QLK5, gene: env, swissprot: Q6QLK5_9HIV1) | A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. | Antihistamine (Code: N0000175750) Histamine Receptor Antagonists (Code: N0000000207) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) H1-receptor antagonist (Code: CHEBI:37955) anxiolytic drug (Code: CHEBI:35474) dermatologic drug (Code: CHEBI:50177) antipruritic drug (Code: CHEBI:59683) | 1956-04-12 FDA | |
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| theodrenaline | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | |
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| gatifloxacin | DNA gyrase subunit A (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WG47, gene: gyrA, swissprot: GYRA_MYCTU) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) DNA topoisomerase 4 subunit A (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0C1U9, gene: parC, swissprot: PARC_STAAU) DNA gyrase (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P0A4L9|P72524, gene: gyrA|gyrB, swissprot: GYRA_STRPN|GYRB_STRPN) DNA topoisomerase 4 (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P72525|Q59961, gene: parC|parE, swissprot: PARC_STRPN|PARE_STRPN) | None | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antiinfective agent (Code: CHEBI:35441) | 2003-03-28 FDA | 5BTD 5BTF |
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| azidocillin | antibiotic similir to ampicillin; minor descriptor (75-86); on line & INDEX MEDICUS search PENICILLIN G/AA (75-86); RN given refers to (2S-(2alpha,5alpha,6beta(S*))-isomer) | |
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| pipamperone | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) first generation antipsychotic (Code: CHEBI:65190) | |
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| tiagabine | Sodium- and chloride-dependent GABA transporter 1 (Organism: Rattus norvegicus, class: Transporter, accessions: P23978, gene: Slc6a1, swissprot: SC6A1_RAT) Sodium- and chloride-dependent GABA transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P30531, gene: SLC6A1, swissprot: SC6A1_HUMAN) Sodium- and chloride-dependent GABA transporter 1 (Organism: Mus musculus, class: Transporter, accessions: P31648, gene: Slc6a1, swissprot: SC6A1_MOUSE) Sodium- and chloride-dependent betaine transporter (Organism: Mus musculus, class: Unclassified, accessions: P31651, gene: Slc6a12, swissprot: S6A12_MOUSE) | The precise mechanism by which tiagabine exerts its antiseizure effect is unknown, although it is believed to be related to its ability to block GABA uptake into presynaptic neurons, permitting more GABA to be available for receptor binding on the surfaces of post-synaptic cells. | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) GABA Agents (Code: D018682) GABA Agonists (Code: D018755) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) GABA reuptake inhibitor (Code: CHEBI:85384) anticonvulsant (Code: CHEBI:35623) | 1997-09-30 FDA | |
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| haloperidol | 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Potassium voltage-gated channel subfamily H member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O95259, gene: KCNH1, swissprot: KCNH1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) AP-2 complex subunit sigma (Organism: Rattus norvegicus, class: Unclassified, accessions: P62744, gene: Ap2s1, swissprot: AP2S1_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) D(3) dopamine receptor (Organism: Chlorocebus aethiops, class: GPCR, accessions: P52703, gene: DRD3, swissprot: DRD3_CHLAE) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) 5-hydroxytryptamine receptor 2A (Organism: Sus scrofa, class: GPCR, accessions: P50129, gene: HTR2A, swissprot: 5HT2A_PIG) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) D(2) dopamine receptor (Organism: Chlorocebus aethiops, class: GPCR, accessions: P52702, gene: DRD2, swissprot: DRD2_CHLAE) Serotonin 2 (5-HT2) receptor (Organism: Mus musculus, class: GPCR, accessions: P34968|P35363|Q02152, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_MOUSE|5HT2B_MOUSE|5HT2C_MOUSE) 5-hydroxytryptamine receptor 2A (Organism: Bos taurus, class: GPCR, accessions: Q75Z89, gene: HTR2A, swissprot: 5HT2A_BOVIN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Protease (Organism: Human rhinovirus sp, class: Enzyme, accessions: Q4U254, gene: protease, swissprot: Q4U254_9ENTO) D(1A) dopamine receptor (Organism: Sus scrofa, class: GPCR, accessions: P50130, gene: DRD1, swissprot: DRD1_PIG) Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) | A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) | Typical Antipsychotic (Code: N0000180182) Anti-Dyskinesia Agents (Code: D018726) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) dopaminergic antagonist (Code: CHEBI:48561) antidyskinesia agent (Code: CHEBI:66956) antiemetic (Code: CHEBI:50919) first generation antipsychotic (Code: CHEBI:65190) serotonergic antagonist (Code: CHEBI:48279) | 1967-04-12 FDA | |
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| riboflavin | Riboflavin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q969G6, gene: RFK, swissprot: RIFK_HUMAN) Flavin reductase (NADPH) (Organism: Homo sapiens, class: Enzyme, accessions: P30043, gene: BLVRB, swissprot: BLVRB_HUMAN) Riboflavin-binding protein (Organism: Gallus gallus, class: Unclassified, accessions: P02752, gene: None, swissprot: RBP_CHICK) | Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE. | Dermatologic Agents (Code: D003879) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) photosensitizing agent (Code: CHEBI:47868) food colouring (Code: CHEBI:77182) B vitamin (Code: CHEBI:75769) | 1953-02-20 FDA | 1BU5 1KYV 1L5R 1MOG 1NB9 1PKV 1T6Z 2A58 2CC8 2CCB 2FL5 2VX9 2VXA 3A35 3A3B 3DDY 3F4G 3P5N 4B2J 4B2K 4B2M 4D1Y 4E0F 4IIL 4KUK 4KUO 4P6V 4R38 4R3A 4ZZD 5IOR 5KBW 5KC0 5KC4 |
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| picotamide | Picotamide is an antiplatelet drug with dual mechanism of action it inhibits thromboxane A2 synthase and antagonizes the pharmacological responses mediated by thromboxane A2 receptor. | Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | |
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| remifentanil | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | Remifentanil is a mu-opioid agonist with rapid onset and peak effect, and short duration of action. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) mu-opioid receptor agonist (Code: CHEBI:55322) opioid analgesic (Code: CHEBI:35482) intravenous anaesthetic (Code: CHEBI:38877) sedative (Code: CHEBI:35717) | 1996-07-12 FDA | |
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| enalapril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P47820, gene: Ace, swissprot: ACE_RAT) | Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Decreased Blood Pressure (Code: N0000178477) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) prodrug (Code: CHEBI:50266) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) antihypertensive agent (Code: CHEBI:35674) | 1985-12-24 FDA | |
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| fluorometholone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732) | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Allergic Agents (Code: D018926) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) | 1972-01-12 FDA | |
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| fluocortolone | A glucocorticoid with anti-inflammatory activity used topically for various skin disorders. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| desoximetasone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) | A topical anti-inflammatory glucocorticoid used in DERMATOSES, skin allergies, PSORIASIS, etc. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) antipruritic drug (Code: CHEBI:59683) | 1977-02-28 FDA | |
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| estradiol benzoate | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) | None | xenoestrogen (Code: CHEBI:76988) | |
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| hexcarbacholine | None | |
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| lauroguadine | None | |
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| flutazolam | None | |
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| haloxazolam | None | |
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| pentolonium | Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor subunit alpha-10 (Organism: Homo sapiens, class: Ion channel, accessions: Q9GZZ6, gene: CHRNA10, swissprot: ACH10_HUMAN) | A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. | Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | None FDA | |
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| morazone | None | |
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| sulfinalol | None | |
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| domitroban | Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Thromboxane A2 receptor (Organism: Mus musculus, class: Unclassified, accessions: P30987, gene: Tbxa2r, swissprot: TA2R_MOUSE) | None | |
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| famprofazone | Nuclear receptor subfamily 2 group E member 1 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q9Y466, gene: NR2E1, swissprot: NR2E1_HUMAN) | None | |
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| ronifibrate | None | |
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| etoperidone | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | None | |
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| ambroxol | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) Glucosylceramidase (Organism: Homo sapiens, class: Enzyme, accessions: P04062, gene: GBA, swissprot: GLCM_HUMAN) | A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride. | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) | 1978-01-01 YEAR INTRODUCED | |
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| mefloquine | Protein kinase Pfmrk (Organism: Plasmodium falciparum, class: Unclassified, accessions: P90584, gene: Pfmrk, swissprot: P90584_PLAFA) Hemoglobin subunit alpha (Organism: Homo sapiens, class: Secreted, accessions: P69905, gene: HBA1, swissprot: HBA_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | A phospholipid-interacting antimalarial drug (ANTIMALARIALS). It is very effective against PLASMODIUM FALCIPARUM with very few side effects. | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antimalarial (Code: CHEBI:38068) | 1989-05-02 FDA | |
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| carbenicillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | None FDA | |
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| fluprednisolone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | A synthetic glucocorticoid with anti-inflammatory properties. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1982-12-07 FDA | |
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| propicillin | major descriptor (64-84); on-line search PENICILLIN, PHENOXYMETHYL/AA (64-84); Index Medicus search PROPICILLIN (64-84); RN given refers to parent cpd(2S-(2alpha,5alpha,6beta))-isomer | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| doxapram | Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) | Increased Medullary Respiratory Drive (Code: N0000009393) Respiratory Stimulant (Code: N0000175716) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Respiratory System Agents (Code: D019141) central nervous system stimulant (Code: CHEBI:35337) | 1965-06-23 FDA | |
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| cyclopenthiazide | Thiazide diuretic also used as an antihypertensive agent. | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | |
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| scarlet red | None | Coloring Agents (Code: D004396) | |
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| droperidol | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593) | Dopamine D2 Antagonists (Code: N0000175799) Dopamine-2 Receptor Antagonist (Code: N0000175800) Adjuvants, Anesthesia (Code: D000759) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Dopamine D2 Receptor Antagonists (Code: D065127) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) antiemetic (Code: CHEBI:50919) dopaminergic antagonist (Code: CHEBI:48561) anaesthesia adjuvant (Code: CHEBI:60807) first generation antipsychotic (Code: CHEBI:65190) | 1970-06-11 FDA | |
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| donepezil | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Choline O-acetyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P32738, gene: Chat, swissprot: CLAT_RAT) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | FDA approved for the treatment of mild to moderate dementia of the Alzheimer type; structure given in first source; RN given refers to HCl; RN for parent cpd not avail 10/92 | Cholinesterase Inhibitor (Code: N0000175723) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Nootropic Agents (Code: D018697) nootropic agent (Code: CHEBI:66980) | 1996-11-25 FDA | 1EVE 4EY7 |
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| celiprolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | A cardioselective beta-1 adrenergic antagonist that has intrinsic symopathomimetic activity. It is used in the management of ANGINA PECTORIS and HYPERTENSION. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-1 Receptor Antagonists (Code: D058671) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasodilator Agents (Code: D014665) | 1982-01-01 YEAR INTRODUCED | |
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| etomidoline | has myolytic activity on extravascular smooth muscle | |
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| oxypertine | None | |
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| coumetarol | None | |
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| meticillin | Beta-lactam-inducible penicillin-binding protein (Organism: Staphylococcus aureus, class: Enzyme, accessions: P07944, gene: pbp, swissprot: PBP_STAAU) NH(3)-dependent NAD(+) synthetase (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P18843, gene: nadE, swissprot: NADE_ECOLI) Penicillin-binding protein (Organism: Staphylococcus aureus, class: Enzyme, accessions: P72355|Q53707|Q53725|Q53729|Q9XDB3, gene: PBP2|mecA|pbp4|pbpA|pbpF, swissprot: P72355_STAAU|Q53707_STAAU|Q53725_STAAU|Q53729_STAAU|Q9XDB3_STAAU) | One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | None FDA | 3KP4 |
|
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| fludrocortisone acetate | Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | A synthetic mineralocorticoid with anti-inflammatory activity. | Anti-Inflammatory Agents (Code: D000893) | 1955-08-18 FDA | |
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| amosulalol | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| bopindolol | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Neurotransmitter Agents (Code: D018377) | 1985-01-01 YEAR INTRODUCED | |
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| ecabet | None | Anti-Infective Agents (Code: D000890) Anti-Ulcer Agents (Code: D000897) Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Protease Inhibitors (Code: D011480) Protective Agents (Code: D020011) | |
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| limaprost | Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) | Limaprost exerts potent effects on vasodilation, increase of blood flow and inhibition of platelet aggregation, and thereby has proven clinical effects on various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | None PMDA | |
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| eprazinone | None | Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) mucolytic (Code: CHEBI:77034) | |
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| trichlormethiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) | A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) | 1960-03-09 FDA | 1ZGF 3ILT |
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| chlorotrianisene | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) | A powerful synthetic, non-steroidal estrogen. | Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Estrogens (Code: D004967) Estrogens, Non-Steroidal (Code: D004968) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) estrogen receptor modulator (Code: CHEBI:50739) antineoplastic agent (Code: CHEBI:35610) xenoestrogen (Code: CHEBI:76988) | None FDA | |
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| celecoxib | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Cytochrome c oxidase subunit 2 (Organism: Ovis aries, class: Enzyme, accessions: O78750, gene: MT-CO2, swissprot: COX2_SHEEP) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Bos taurus, class: Enzyme, accessions: O62698, gene: PTGS2, swissprot: PGH2_BOVIN) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) Prostaglandin G/H synthase 1 (Organism: Mus musculus, class: Enzyme, accessions: P22437, gene: Ptgs1, swissprot: PGH1_MOUSE) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Prostaglandin G/H synthase 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355, gene: Ptgs2, swissprot: PGH2_RAT) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein (Organism: Canis familiaris, class: Enzyme, accessions: Q8SPQ9, gene: PTGS2, swissprot: Q8SPQ9_CANFA) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Prostaglandin G/H synthase 1 (Organism: Canis familiaris, class: Enzyme, accessions: Q8HZR1, gene: PTGS1, swissprot: PGH1_CANFA) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Prostaglandin G/H synthase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63921, gene: Ptgs1, swissprot: PGH1_RAT) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Cytochrome c oxidase subunit 1 (Organism: Ovis aries, class: Unclassified, accessions: O78749, gene: MT-CO1, swissprot: COX1_SHEEP) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN. | Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase 2 Inhibitors (Code: D052246) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-narcotic analgesic (Code: CHEBI:35481) | 1998-12-31 FDA | 1OQ5 3KK6 3LN1 4FIM 5JW1 |
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| fendosal | Plasminogen activator inhibitor 1 (Organism: Homo sapiens, class: Secreted, accessions: P05121, gene: SERPINE1, swissprot: PAI1_HUMAN) | None | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) | |
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| benperidol | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567) | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1965-01-01 YEAR INTRODUCED | |
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| micinicate | None | |
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| econazole | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Neuropeptide Y receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P49146, gene: NPY2R, swissprot: NPY2R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) Malate dehydrogenase cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P40925, gene: MDH1, swissprot: MDHC_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | An imidazole derivative that is commonly used as a topical antifungal agent. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) | 1982-12-23 FDA | 2UVN 3JUS 3OZV 3R9C 4G1B |
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| azelastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) | Azelastine hydrochloride, a phthalazinone derivative, exhibits histamine H1-receptor antagonist activity in isolated tissues, animal models, and humans. Azelastine Hydrochloride is administered as a racemic mixture with no difference in pharmacologic activity noted between the enantiomers in in vitro studies. The major metabolite, desmethylazelastine, also possesses H1-receptor antagonist activity. | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) Anti-Allergic Agents (Code: D018926) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Enzyme Inhibitors (Code: D004791) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Lipoxygenase Inhibitors (Code: D016859) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) anti-asthmatic drug (Code: CHEBI:49167) bronchodilator agent (Code: CHEBI:35523) platelet aggregation inhibitor (Code: CHEBI:50427) | 1996-11-01 FDA | |
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| mebutizide | None | |
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| tofisopam | None | Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | None PMDA | |
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| tetrofosmin | Tetrofosmin is a diagnostic agent used to assess areas of reversible myocardial ischemia in the presence or absence of infracted myocardium and is also used to assess ventricular function. | None FDA | |
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| alpiropride | None | |
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| eletriptan | 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) | Eletriptan binds with high affinity to 5-HT1B, 5-HT1D and 5-HT1F receptors, has modest affinity for 5-HT1A, 5-HT1E, 5-HT2B and 5-HT7 receptors. Migraines are likely due to local cranial vasodilatation and/or to the release of sensory neuropeptides (vasoactive intestinal peptide, substance P and calcitonin gene-related peptide) through nerve endings in the trigeminal system. The therapeutic activity of Eletriptan for the treatment of migraine headache is thought to be due to the agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels (including the arterio-venous anastomoses) and sensory nerves of the trigeminal system which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release. | Serotonin 1b Receptor Agonists (Code: N0000175763) Serotonin 1d Receptor Agonists (Code: N0000175764) Serotonin-1b and Serotonin-1d Receptor Agonist (Code: N0000175765) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) serotonergic agonist (Code: CHEBI:35941) vasoconstrictor agent (Code: CHEBI:50514) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 2002-12-26 FDA | |
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| pyrvinium | None | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) | None FDA | |
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| teflurane | None | |
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| misoprostol | Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) | A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. | Prostaglandin E1 Analog (Code: N0000175785) Prostaglandins E, Synthetic (Code: N0000007710) Abortifacient Agents (Code: D000019) Abortifacient Agents, Nonsteroidal (Code: D000020) Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) anti-ulcer drug (Code: CHEBI:49201) oxytocic (Code: CHEBI:36063) abortifacient (Code: CHEBI:50691) | 1988-12-27 FDA | |
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| mefruside | A benzene-sulfonamide-furan. It is used as a diuretic that affects the concentrating ability of the KIDNEY, increases SODIUM CHLORIDE excretion, but may not spare POTASSIUM. It inhibits CARBONIC ANHYDRASES and may increase the blood URIC ACID level. | Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) | |
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| loratadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Sodium-dependent neutral amino acid transporter B(0)AT2 (Organism: Homo sapiens, class: Transporter, accessions: Q9H2J7, gene: SLC6A15, swissprot: S6A15_HUMAN) | A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness. | Anti-Allergic Agents (Code: D018926) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | 1993-04-12 FDA | |
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| pantoprazole | Potassium-transporting ATPase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P18597|P27112, gene: ATP4A|ATP4B, swissprot: ATP4A_RABIT|ATP4B_RABIT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) Fatty acid synthase (Organism: Homo sapiens, class: Enzyme, accessions: P49327, gene: FASN, swissprot: FAS_HUMAN) | Pantoprazole sodium is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours. | Proton Pump Inhibitor (Code: N0000175525) Anti-Ulcer Agents (Code: D000897) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Proton Pump Inhibitors (Code: D054328) anti-ulcer drug (Code: CHEBI:49201) | 2000-02-02 FDA | |
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| ceftizoxime | Beta-lactamase (Organism: Bacillus licheniformis, class: Enzyme, accessions: P00808, gene: penP, swissprot: BLAC_BACLI) Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1983-09-15 FDA | |
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| veralipride | used in treatment of menopausal disorders; RN given refers to parent cpd | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| meropenem | Penicillin-binding protein 2 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q9X6V3, gene: pbpA, swissprot: Q9X6V3_PSEAI) Penicillin-binding protein 4 (Organism: Staphylococcus aureus, class: Enzyme, accessions: Q5D1E9, gene: None, swissprot: Q5D1E9_STAAU) D-ala-D-ala-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase family protein; Penicillin-binding protein 5 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q9X6V7, gene: dacA, swissprot: Q9X6V7_PSEAI) Penicillin-binding protein 1 (Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18), class: Enzyme, accessions: A1KS91, gene: ponA, swissprot: A1KS91_NEIMF) D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6 (Organism: Yersinia pestis, class: Enzyme, accessions: Q7CHG0, gene: dacC, swissprot: Q7CHG0_YERPE) D-alanyl-D-alanine carboxypeptidase DacB (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P24228, gene: dacB, swissprot: DACB_ECOLI) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Beta-lactamase class B VIM-2 (Organism: Pseudomonas aeruginosa, class: Unclassified, accessions: Q9K2N0, gene: blaVIM-2, swissprot: Q9K2N0_PSEAI) | an antibacterial drug readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets, the bactericidal activity of meropenem results from the inhibition of cell wall synthesis | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) drug allergen (Code: CHEBI:88188) antibacterial drug (Code: CHEBI:36047) | 1996-06-21 FDA | 4EUZ |
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| tandospirone | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Tranquilizing Agents (Code: D014149) | |
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| quetiapine | 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER. | Atypical Antipsychotic (Code: N0000175430) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) histamine antagonist (Code: CHEBI:37956) adrenergic antagonist (Code: CHEBI:37887) second generation antipsychotic (Code: CHEBI:65191) | 1997-09-26 FDA | |
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| brinzolamide | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) | an antiglaucoma agent | Carbonic Anhydrase Inhibitor (Code: N0000175517) Carbonic Anhydrase Inhibitors (Code: D002257) Enzyme Inhibitors (Code: D004791) antiglaucoma drug (Code: CHEBI:39456) | 1998-04-01 FDA | 3ZNC 4M2R 4M2V 6BBS |
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| mebrofenin | None | None FDA | |
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| naftidrofuryl | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors. | Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Vasodilator Agents (Code: D014665) | |
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| denaverine | None | |
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| melinamide | None | |
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| altizide | None | 3IJO |
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| bortezomib | Proteasome subunit alpha type-1 (Organism: Homo sapiens, class: Enzyme, accessions: P25786, gene: PSMA1, swissprot: PSA1_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) PH and SEC7 domain-containing protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: A5PKW4, gene: PSD, swissprot: PSD1_HUMAN) Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Cathepsin G (Organism: Homo sapiens, class: Enzyme, accessions: P08311, gene: CTSG, swissprot: CATG_HUMAN) Lysosomal protective protein (Organism: Homo sapiens, class: Enzyme, accessions: P10619, gene: CTSA, swissprot: PPGB_HUMAN) Alpha-chymotrypsin (Organism: Bos taurus, class: Unclassified, accessions: P00766, gene: None, swissprot: CTRA_BOVIN) Chymase (Organism: Homo sapiens, class: Enzyme, accessions: P23946, gene: CMA1, swissprot: CMA1_HUMAN) Chymotrypsinogen B (Organism: Homo sapiens, class: Enzyme, accessions: P17538, gene: CTRB1, swissprot: CTRB1_HUMAN) Proteasome subunit beta type-1 (Organism: Homo sapiens, class: Enzyme, accessions: P20618, gene: PSMB1, swissprot: PSB1_HUMAN) Proteasome subunit beta type-5 (Organism: Homo sapiens, class: Enzyme, accessions: P28074, gene: PSMB5, swissprot: PSB5_HUMAN) Proteasome subunit beta type-2 (Organism: Homo sapiens, class: Enzyme, accessions: P49721, gene: PSMB2, swissprot: PSB2_HUMAN) Nuclear factor NF-kappa-B complex (Organism: Homo sapiens, class: Unclassified, accessions: P19838|Q00653|Q04206, gene: NFKB1|NFKB2|RELA, swissprot: NFKB1_HUMAN|NFKB2_HUMAN|TF65_HUMAN) Proteasome subunit beta type-8 (Organism: Homo sapiens, class: Enzyme, accessions: P28062, gene: PSMB8, swissprot: PSB8_HUMAN) Neutrophil elastase (Organism: Homo sapiens, class: Enzyme, accessions: P08246, gene: ELANE, swissprot: ELNE_HUMAN) 26S proteasome non-ATPase regulatory subunit 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q99460, gene: PSMD1, swissprot: PSMD1_HUMAN) | A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA. | Proteasome Inhibitors (Code: N0000175075) Antineoplastic Agents (Code: D000970) antineoplastic agent (Code: CHEBI:35610) antiprotozoal drug (Code: CHEBI:35820) proteasome inhibitor (Code: CHEBI:52726) | 2003-05-13 FDA | 2F16 3MG0 4FWD 4QVL 4QVM 4QVN 4QVP 4QVQ 4QVV 4QVW 4QVY 4QW0 4QW1 4QW3 4QWU 4YPM 5BXN 5CZ7 5D0X 5L5F 5L5Z 5L66 5LF3 |
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| felodipine | Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Cystic fibrosis transmembrane conductance regulator (Organism: Homo sapiens, class: Ion channel, accessions: P13569, gene: CFTR, swissprot: CFTR_HUMAN) | A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) anti-arrhythmia drug (Code: CHEBI:38070) | 1991-07-25 FDA | 2NNJ |
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| artesunate | None | Amebicides (Code: D000563) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antimalarial (Code: CHEBI:38068) | |
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| ticarcillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | An antibiotic derived from penicillin similar to CARBENICILLIN in action. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1976-11-09 FDA | |
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| bufogenin | respiratory stimulant; from toad; structure | Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Protective Agents (Code: D020011) | |
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| estradiol dipropionate | None | |
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| zipeprol | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| perimetazine | None | |
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| estradiol enanthate | None | Estrogens (Code: D004967) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| ibutilide | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | None | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | 1995-12-28 FDA | |
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| nilvadipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) | None | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | 1992-01-01 YEAR INTRODUCED | |
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| perflutren | Perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood. These physical acoustic properties of activated perflutren provide contrast enhancement of the left ventricular chamber and aid delineation of the left ventricular endocardial border during echocardiography. | Contrast Agent for Ultrasound Imaging (Code: N0000175864) Ultrasound Contrast Activity (Code: N0000010259) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 2001-07-31 FDA | |
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| bamifylline | None | Analgesics (Code: D000700) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) Vasodilator Agents (Code: D014665) | |
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| racecadotril | Neprilysin (Organism: Homo sapiens, class: Enzyme, accessions: P08473, gene: MME, swissprot: NEP_HUMAN) Thermolysin (Organism: Bacillus thermoproteolyticus, class: Unclassified, accessions: P00800, gene: npr, swissprot: THER_BACTH) Neprilysin (Organism: Oryctolagus cuniculus, class: Unclassified, accessions: P08049, gene: MME, swissprot: NEP_RABIT) Neprilysin (Organism: Rattus norvegicus, class: Enzyme, accessions: P07861, gene: Mme, swissprot: NEP_RAT) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Neprilysin (Organism: Sus scrofa, class: Unclassified, accessions: P19621, gene: MME, swissprot: NEP_PIG) Endothelin-converting enzyme 1 (Organism: Homo sapiens, class: Unclassified, accessions: P42892, gene: ECE1, swissprot: ECE1_HUMAN) | A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. | Antidiarrheals (Code: D000930) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Protease Inhibitors (Code: D011480) | 1993-01-01 YEAR INTRODUCED | |
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| buspirone | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) 5-hydroxytryptamine receptor 2A (Organism: Bos taurus, class: GPCR, accessions: Q75Z89, gene: HTR2A, swissprot: 5HT2A_BOVIN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) | An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM. | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Tranquilizing Agents (Code: D014149) serotonergic agonist (Code: CHEBI:35941) sedative (Code: CHEBI:35717) anxiolytic drug (Code: CHEBI:35474) | 1986-09-29 FDA | |
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| fosfluconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) | prodrug of fluconazole | 14-alpha Demethylase Inhibitors (Code: D058888) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) prodrug (Code: CHEBI:50266) | 2004-01-01 YEAR INTRODUCED | |
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| piposulfan | None | |
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| anecortave | Plasminogen activator inhibitor 1 (Organism: Homo sapiens, class: Secreted, accessions: P05121, gene: SERPINE1, swissprot: PAI1_HUMAN) | None | Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) | 2006-01-01 YEAR INTRODUCED | |
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| medibazine | None | |
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| sufentanil | Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) | An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Adjuvants, Anesthesia (Code: D000759) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) anaesthesia adjuvant (Code: CHEBI:60807) intravenous anaesthetic (Code: CHEBI:38877) | 1984-05-04 FDA | |
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| mesoridazine | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) | A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) dopaminergic antagonist (Code: CHEBI:48561) first generation antipsychotic (Code: CHEBI:65190) | 1970-02-27 FDA | |
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| quazepam | GABA A receptor alpha-3/beta-1/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18505|P18507|P34903, gene: GABRA3|GABRB1|GABRG2, swissprot: GBRA3_HUMAN|GBRB1_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-2/beta-1/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18505|P18507|P47869, gene: GABRA2|GABRB1|GABRG2, swissprot: GBRA2_HUMAN|GBRB1_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-1/beta-1/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18505|P18507, gene: GABRA1|GABRB1|GABRG2, swissprot: GBRA1_HUMAN|GBRB1_HUMAN|GBRG2_HUMAN) | None | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1985-12-27 FDA | |
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| terazosin | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) | induces decreased blood pressure; used in the treatment of benign prostatic hyperplasia | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) antineoplastic agent (Code: CHEBI:35610) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic antagonist (Code: CHEBI:37890) | 1987-08-07 FDA | 4O33 4O3F |
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| trimebutine | Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders. | Autonomic Agents (Code: D001337) Gastrointestinal Agents (Code: D005765) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| urapidil | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Vasodilator Agents (Code: D014665) | 1981-01-01 YEAR INTRODUCED | |
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| gusperimus | synthesized by chemical modification of spergualin; in combination with cyclosporin A prevents diabetes in predisposed NOD mice; structure given in first source; RN given refers to (-)-isomer trihydrochloride | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Hypoglycemic Agents (Code: D007004) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) | |
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| teclothiazide | None | |
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| tioconazole | Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) | None | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) antiinfective agent (Code: CHEBI:35441) | 1983-02-18 FDA | |
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| benzylhydrochlorothiazide | thiazide diuretic used as a blood pressure-lowering agent | |
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| flurazepam | Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) | A benzodiazepine derivative used mainly as a hypnotic. | Benzodiazepine (Code: N0000175694) Benzodiazepines (Code: N0000007542) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1970-04-07 FDA | 2YOE |
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| nemonapride | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) | an atypical antipsychotic approved in Japan for the treatment of schizophrenia | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) dopaminergic antagonist (Code: CHEBI:48561) serotonergic agonist (Code: CHEBI:35941) second generation antipsychotic (Code: CHEBI:65191) | 5WIU 5WIV |
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| oxantel | oxyphenyl analog of pyrantel; RN given refers to (E)-isomer; synonym CP-14,445-16 refers to oxantel pamoate | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) | |
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| aranidipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | |
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| visnadine | None | |
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| nisoldipine | Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Organism: Homo sapiens, class: Ion channel, accessions: O00555, gene: CACNA1A, swissprot: CAC1A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina. | Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Calcium Channel Antagonists (Code: N0000000069) Decreased Blood Pressure (Code: N0000178477) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) platelet aggregation inhibitor (Code: CHEBI:50427) cardiovascular drug (Code: CHEBI:35554) | 1995-02-02 FDA | |
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| trimethobenzamide | major descriptor (64-84); on-line search BENZAMIDES (64-84); Index Medicus search TRIMETHOBENZAMIDE (64-84); RN given refers to parent cpd | Emesis Suppression (Code: N0000009034) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) antiemetic (Code: CHEBI:50919) | 1974-07-12 FDA | |
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| zopiclone | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903|P47870|Q99928, gene: GABRA3|GABRB2|GABRG3, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P47870|Q99928, gene: GABRA1|GABRB2|GABRG3, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P31644|P47870|Q99928, gene: GABRA5|GABRB2|GABRG3, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) GABA A receptor alpha-5/beta-3/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472|P31644|Q99928, gene: GABRA5|GABRB3|GABRG3, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; was term of zopiclone 2004-2007 | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) central nervous system depressant (Code: CHEBI:35488) sedative (Code: CHEBI:35717) | 2004-12-15 FDA | 4A97 |
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| eszopiclone | GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P34903|P47870, gene: GABRA3|GABRB2|GABRG2, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-3/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903|P47870|Q99928, gene: GABRA3|GABRB2|GABRG3, swissprot: GBRA3_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P47870|Q99928, gene: GABRA1|GABRB2|GABRG3, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) GABA A receptor alpha-5/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P31644|P47870, gene: GABRA5|GABRB2|GABRG2, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-5/beta-2/gamma-3 (Organism: Homo sapiens, class: Ion channel, accessions: P31644|P47870|Q99928, gene: GABRA5|GABRB2|GABRG3, swissprot: GBRA5_HUMAN|GBRB2_HUMAN|GBRG3_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-4 (Organism: Homo sapiens, class: Ion channel, accessions: P48169, gene: GABRA4, swissprot: GBRA4_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P47869, gene: GABRA2, swissprot: GBRA2_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P14867, gene: GABRA1, swissprot: GBRA1_HUMAN) Gamma-aminobutyric acid receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P34903, gene: GABRA3, swissprot: GBRA3_HUMAN) | A pyridine, pyrazine, and piperazine derivative that is used as a HYPNOTIC AND SEDATIVE in the treatment of INSOMNIA. | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) sedative (Code: CHEBI:35717) central nervous system depressant (Code: CHEBI:35488) | 2004-12-15 FDA | |
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| fipexide | regulates dopaminergic systems at macromolecular level | |
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| levocetirizine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | 2007-05-25 FDA | 5DQF |
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| cetirizine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) Anti-Allergic Agents (Code: D018926) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) | 1995-12-08 FDA | 5DQF |
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| bepotastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | Histamine-1 Receptor Antagonist (Code: N0000175587) Anti-Allergic Agents (Code: D018926) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) | 2009-09-08 FDA | |
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| gemifloxacin | DNA gyrase subunit B (Organism: Escherichia coli O157:H7, class: Enzyme, accessions: P0AES7, gene: gyrB, swissprot: GYRB_ECO57) DNA topoisomerase 4 subunit A (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P72525, gene: parC, swissprot: PARC_STRPN) DNA topoisomerase 4 subunit A (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0C1U9, gene: parC, swissprot: PARC_STAAU) | a fluoronaphthyridone | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) | 2002-12-27 Korean Food and Drug Administration (KFDA) 2003-04-04 FDA | |
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| tadalafil | cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: O54735, gene: Pde5a, swissprot: PDE5A_RAT) Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Organism: Bos taurus, class: Enzyme, accessions: P11541, gene: PDE6A, swissprot: PDE6A_BOVIN) Phosphodiesterase 6 (Organism: Homo sapiens, class: Enzyme, accessions: O43924|P16499|P18545|P35913|P51160|Q13956, gene: PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H, swissprot: CNCG_HUMAN|CNRG_HUMAN|PDE6A_HUMAN|PDE6B_HUMAN|PDE6C_HUMAN|PDE6D_HUMAN) Phosphodiesterase 6 (Organism: Bos taurus, class: Enzyme, accessions: P04972|P11541|P16586|P22571|P23439|Q95142, gene: PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H, swissprot: CNCG_BOVIN|CNRG_BOVIN|PDE6A_BOVIN|PDE6B_BOVIN|PDE6C_BOVIN|PDE6D_BOVIN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Bos taurus, class: Enzyme, accessions: Q28156, gene: PDE5A, swissprot: PDE5A_BOVIN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCR9, gene: PDE11A, swissprot: PDE11_HUMAN) | A carboline derivative and PHOSPHODIESTERASE 5 INHIBITOR that is used primarily to treat ERECTILE DYSFUNCTION; BENIGN PROSTATIC HYPERPLASIA and PRIMARY PULMONARY HYPERTENSION. | Phosphodiesterase 5 Inhibitor (Code: N0000175599) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase 5 Inhibitors (Code: D058986) Phosphodiesterase Inhibitors (Code: D010726) Urological Agents (Code: D064804) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) | 2003-11-21 FDA | 1UDU 1XOZ |
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| reproterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | |
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| balofloxacin | showed potent bactericidal activity & inhibited the supercoiling activity of DNA gyrase of S. aureus, E. coli, & P aeruginosa; structure given in first source | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 2001-12-31 Korean Food and Drug Administration (KFDA) | |
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| cefprozil | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) | None | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1991-12-23 FDA | |
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| alfuzosin | Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) | Alfuzosin is a selective antagonist of post-synaptic alpha1-adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) antineoplastic agent (Code: CHEBI:35610) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic antagonist (Code: CHEBI:37890) | 2003-06-12 FDA | |
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| hetacillin | Penicillin-binding protein (Organism: Streptococcus pneumoniae, class: Enzyme, accessions: Q54618|Q75Y37|Q75Y54|Q75YD8|Q75YK0|Q9RET4, gene: PBP2X|pbp1a|pbp1b|pbp2a|pbp2b|pbp3, swissprot: Q54618_STREE|Q75Y37_STREE|Q75Y54_STREE|Q75YD8_STREE|Q75YK0_STREE|Q9RET4_STREE) | None | antibacterial drug (Code: CHEBI:36047) | None FDA | |
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| cyclothiazide | Glutamate receptor 2 (Organism: Homo sapiens, class: Ion channel, accessions: P42262, gene: GRIA2, swissprot: GRIA2_HUMAN) Glutamate receptor ionotropic, AMPA (Organism: Rattus norvegicus, class: Ion channel, accessions: P19490|P19491|P19492|P19493, gene: Gria1|Gria2|Gria3|Gria4, swissprot: GRIA1_RAT|GRIA2_RAT|GRIA3_RAT|GRIA4_RAT) Glutamate receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P42261, gene: GRIA1, swissprot: GRIA1_HUMAN) Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Glutamate receptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P42263, gene: GRIA3, swissprot: GRIA3_HUMAN) Glutamate receptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: P48058, gene: GRIA4, swissprot: GRIA4_HUMAN) | inhibits the desensitization of AMPA-type receptors; structure | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Natriuretic Agents (Code: D045283) antihypertensive agent (Code: CHEBI:35674) diuretic (Code: CHEBI:35498) | 1982-06-08 FDA | 1LBC 3H6T 3TKD |
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| regadenoson | Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) | None | Adenosine Receptor Agonist (Code: N0000178375) Adenosine Receptor Agonists (Code: N0000175788) Adenosine A2 Receptor Agonists (Code: D058908) Neurotransmitter Agents (Code: D018377) Purinergic Agents (Code: D058905) Purinergic Agonists (Code: D058913) Purinergic P1 Receptor Agonists (Code: D058906) | 2008-04-10 FDA | |
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| treprostinil | Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) | None | Prostacycline Vasodilator (Code: N0000175416) Prostaglandins I (Code: N0000011280) Vasodilation (Code: N0000009909) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) platelet aggregation inhibitor (Code: CHEBI:50427) vasodilator agent (Code: CHEBI:35620) antihypertensive agent (Code: CHEBI:35674) cardiovascular drug (Code: CHEBI:35554) | 2002-05-21 FDA | |
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| oxamarin | None | |
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| meclozine | Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Constitutive androstane receptor (Organism: Mus musculus, class: Unclassified, accessions: O35627, gene: Nr1i3, swissprot: NR1I3_MOUSE) | A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. | Antiemetic (Code: N0000178372) Emesis Suppression (Code: N0000009034) Anti-Allergic Agents (Code: D018926) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | 1957-02-14 FDA | |
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| flavoxate | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) Phosphodiesterase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q13946|Q9NP56, gene: PDE7A|PDE7B, swissprot: PDE7A_HUMAN|PDE7B_HUMAN) Phosphodiesterase 8 (Organism: Homo sapiens, class: Enzyme, accessions: O60658|O95263, gene: PDE8A|PDE8B, swissprot: PDE8A_HUMAN|PDE8B_HUMAN) | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. | Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Urological Agents (Code: D064804) parasympatholytic (Code: CHEBI:50370) muscarinic antagonist (Code: CHEBI:48876) antispasmodic drug (Code: CHEBI:53784) | 1970-01-15 FDA | |
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| biriperone | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | None | |
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| dimetotiazine | has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions; minor descriptor (75-84); on-line & Index Medicus search PHENOTHIAZINES (75-84); RN given refers to parent cpd | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| dithiazanine | 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium. A benzothiazole that was formerly used as an antinematodal agent and is currently used as a fluorescent dye. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Coloring Agents (Code: D004396) Fluorescent Dyes (Code: D005456) Indicators and Reagents (Code: D007202) Luminescent Agents (Code: D049408) fluorochrome (Code: CHEBI:51217) anthelminthic drug (Code: CHEBI:35443) | |
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| sparfloxacin | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Topoisomerase IV (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2|P20083, gene: parC|parE, swissprot: PARC_ECOLI|PARE_ECOLI) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antitubercular Agents (Code: D000995) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1996-12-19 FDA | |
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| cinepazet | None | |
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| paramethasone acetate | A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737) | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | None FDA | |
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| dexamethasone | Interleukin-4 (Organism: Homo sapiens, class: Cytokine, accessions: P05112, gene: IL4, swissprot: IL4_HUMAN) Interleukin-5 (Organism: Homo sapiens, class: Cytokine, accessions: P05113, gene: IL5, swissprot: IL5_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Mus musculus, class: Nuclear hormone receptor, accessions: O54915, gene: Nr1i2, swissprot: NR1I2_MOUSE) | An anti-inflammatory 9-fluoro-glucocorticoid. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Antiemetics (Code: D000932) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Peripheral Nervous System Agents (Code: D018373) antiemetic (Code: CHEBI:50919) adrenergic agent (Code: CHEBI:37962) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) anti-inflammatory drug (Code: CHEBI:35472) | 1958-10-30 FDA | 1M2Z 1P93 3GN8 3MNE 3MNO 3MNP 4UDA 4UDC |
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| betamethasone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) | A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724) | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Respiratory System Agents (Code: D019141) anti-asthmatic agent (Code: CHEBI:65023) immunosuppressive agent (Code: CHEBI:35705) anti-inflammatory drug (Code: CHEBI:35472) | 1961-04-17 FDA | |
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| naftopidil | Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Platelet Aggregation Inhibitors (Code: D010975) | 1998-12-25 PMDA | |
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| trospium | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | None | Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Urological Agents (Code: D064804) | 2004-05-28 FDA | |
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| tiotropium bromide | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) | A scopolamine derivative and CHOLINERGIC ANTAGONIST that functions as a BRONCHODILATOR AGENT. It is used in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. | Anticholinergic (Code: N0000175574) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) muscarinic antagonist (Code: CHEBI:48876) bronchodilator agent (Code: CHEBI:35523) | 2004-01-30 FDA | |
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| halopropane | None | |
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| dextromoramide | An opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070) | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) opioid analgesic (Code: CHEBI:35482) | |
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| iocetamic acid | was MH 1975-92 (see under IODOBENZENES 1975-90); use IODOBENZENES to search IOCETAMIC ACID 1975-92 | None FDA | |
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| ursodiol | Aldo-keto reductase family 1 member C2 (Organism: Homo sapiens, class: Enzyme, accessions: P52895, gene: AKR1C2, swissprot: AK1C2_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) M1-family alanyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8IEK1, gene: None, swissprot: Q8IEK1_PLAF7) | An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. | Bile Acid (Code: N0000175802) Bile Acids and Salts (Code: N0000006801) Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) | 1987-12-31 FDA | |
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| chloroprednisone | None | |
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| cloprednol | relative anti-inflammatory potency twice prednisolone; synthetic glucocorticoid; structure | |
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| perflubutane | component of the echo contrast agent, BR14, which consists of perfluorobutane gas microbubbles | |
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| pentetic acid | lead (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) | An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium. | Lead Chelating Activity (Code: N0000175962) Lead Chelator (Code: N0000175963) Antidotes (Code: D000931) Chelating Agents (Code: D002614) Iron Chelating Agents (Code: D007502) Protective Agents (Code: D020011) Sequestering Agents (Code: D064449) | None FDA | |
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| rubitecan | None | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase I Inhibitors (Code: D059004) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) | |
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| sulfaloxic acid | None | |
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| erlotinib | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Tubulin alpha-1A chain (Organism: Rattus norvegicus, class: Structural, accessions: P68370, gene: Tuba1a, swissprot: TBA1A_RAT) Serine/threonine-protein kinase MRCK gamma (Organism: Homo sapiens, class: Kinase, accessions: Q6DT37, gene: CDC42BPG, swissprot: MRCKG_HUMAN) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92630, gene: DYRK2, swissprot: DYRK2_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Casein kinase I isoform delta (Organism: Homo sapiens, class: Kinase, accessions: P48730, gene: CSNK1D, swissprot: KC1D_HUMAN) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) Mitogen-activated protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P31152, gene: MAPK4, swissprot: MK04_HUMAN) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) AarF domain-containing protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96D53, gene: COQ8B, swissprot: COQ8B_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Chaperone activity of bc1 complex-like, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q8NI60, gene: COQ8A, swissprot: COQ8A_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Mus musculus, class: Kinase, accessions: Q3U3Q1, gene: Ulk3, swissprot: ULK3_MOUSE) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Organism: Homo sapiens, class: Kinase, accessions: Q8TBX8, gene: PIP4K2C, swissprot: PI42C_HUMAN) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit delta (Organism: Homo sapiens, class: Kinase, accessions: Q13557, gene: CAMK2D, swissprot: KCC2D_HUMAN) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Ephrin type-A receptor 7 (Organism: Homo sapiens, class: Kinase, accessions: Q15375, gene: EPHA7, swissprot: EPHA7_HUMAN) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) Solute carrier organic anion transporter family member 2B1 (Organism: Homo sapiens, class: Unclassified, accessions: O94956, gene: SLCO2B1, swissprot: SO2B1_HUMAN) | A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine kinase. It is used in the treatment of NON-SMALL CELL LUNG CANCER. | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2004-11-18 FDA | 1M17 4HJO |
|
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| amsacrine | DNA topoisomerase I, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q969P6, gene: TOP1MT, swissprot: TOP1M_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) DNA topoisomerase 2-beta (Organism: Homo sapiens, class: Enzyme, accessions: Q02880, gene: TOP2B, swissprot: TOP2B_HUMAN) DNA topoisomerase II (Organism: Homo sapiens, class: Enzyme, accessions: P11388|Q02880, gene: TOP2A|TOP2B, swissprot: TOP2A_HUMAN|TOP2B_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) | An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent. | Antineoplastic Agents (Code: D000970) Indicators and Reagents (Code: D007202) Intercalating Agents (Code: D007364) antineoplastic agent (Code: CHEBI:35610) | 1987-01-01 YEAR INTRODUCED | 4G0U |
|
|
| brotizolam | Platelet-activating factor receptor (Organism: Homo sapiens, class: GPCR, accessions: P25105, gene: PTAFR, swissprot: PTAFR_HUMAN) | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | 1983-01-01 YEAR INTRODUCED | |
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| metaclazepam | None | |
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| besifloxacin | Topoisomerase IV (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2|P20083, gene: parC|parE, swissprot: PARC_ECOLI|PARE_ECOLI) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) | Besifloxacin is an 8-chloro fluoroquinolone with a N-1 cyclopropyl group. The compound has activity against Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme required for replication, transcription and repair of bacterial DNA. Topoisomerase IV is an essential enzyme required for partitioning of the chromosomal DNA during bacterial cell division. | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) | 2009-05-28 FDA | |
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| ambuside | None | |
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| triamcinolone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) | A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-allergic agent (Code: CHEBI:50857) anti-inflammatory drug (Code: CHEBI:35472) | 1957-12-03 FDA | |
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| diflucortolone | A topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| fluacizine | Russian drug; 2-trifluoromethyl analog of chloracizine; RN given refers to parent cpd | |
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| gemeprost | used for preoperative dilation of cervix before surgical abortion; RN given refers to (2E,11alpha,13E,15R)-isomer | Abortifacient Agents (Code: D000019) Abortifacient Agents, Nonsteroidal (Code: D000020) Reproductive Control Agents (Code: D012102) | |
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| cefdinir | Pencillin binding protein 2a; Penicillin binding protein 2'; Penicillin binding protein, PBP2; Penicillin-binding protein 2; Penicillin-binding protein 2'; Peptidase (Organism: Staphylococcus aureus, class: Unclassified, accessions: O54286, gene: mecA, swissprot: O54286_STAAU) Penicillin-binding protein 3 (Organism: Haemophilus influenzae, class: Unclassified, accessions: Q14TG6, gene: pbp3, swissprot: Q14TG6_HAEIF) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | synthetic antibiotic | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1997-12-04 FDA | |
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| cloricromen | None | Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | |
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| timiperone | None | Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| ketanserin | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Chromaffin granule amine transporter (Organism: Homo sapiens, class: Transporter, accessions: P54219, gene: SLC18A1, swissprot: VMAT1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Mus musculus, class: Unclassified, accessions: P28334, gene: Htr1b, swissprot: 5HT1B_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) | A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients. | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Neurotransmitter Agents (Code: D018377) Platelet Aggregation Inhibitors (Code: D010975) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) antihypertensive agent (Code: CHEBI:35674) cardiovascular drug (Code: CHEBI:35554) alpha-adrenergic antagonist (Code: CHEBI:37890) serotonergic antagonist (Code: CHEBI:48279) | 1985-01-01 YEAR INTRODUCED | |
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| vesnarinone | cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Organism: Homo sapiens, class: Enzyme, accessions: Q13370, gene: PDE3B, swissprot: PDE3B_HUMAN) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) Transitional endoplasmic reticulum ATPase (Organism: Homo sapiens, class: Enzyme, accessions: P55072, gene: VCP, swissprot: TERA_HUMAN) | None | Adjuvants, Immunologic (Code: D000276) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) | |
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| spiperone | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) Dopamine receptor (Organism: Mus musculus, class: Unclassified, accessions: P30728|P51436|P61168|Q61616|Q8BLD9, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_MOUSE|DRD2_MOUSE|DRD3_MOUSE|DRD4_MOUSE|DRD5_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Vesicular acetylcholine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q62666, gene: Slc18a3, swissprot: VACHT_RAT) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Beta-casein (Organism: Rattus norvegicus, class: Unclassified, accessions: P02665, gene: Csn2, swissprot: CASB_RAT) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) 5-hydroxytryptamine receptor 1B (Organism: Mus musculus, class: Unclassified, accessions: P28334, gene: Htr1b, swissprot: 5HT1B_MOUSE) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) | A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) psychotropic drug (Code: CHEBI:35471) dopaminergic antagonist (Code: CHEBI:48561) serotonergic antagonist (Code: CHEBI:48279) alpha-adrenergic antagonist (Code: CHEBI:37890) antipsychotic agent (Code: CHEBI:35476) | 1969-01-01 YEAR INTRODUCED | |
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| ethaverine | tetraethyl homolog of papaverine; smooth muscle relaxant; RN given refers to parent cpd; structure | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| quinagolide | Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) | None | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | |
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| cefalotin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Tyrosine-protein phosphatase non-receptor type 7 (Organism: Homo sapiens, class: Enzyme, accessions: P35236, gene: PTPN7, swissprot: PTN7_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A cephalosporin antibiotic. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1974-12-18 FDA | 1KVL 2ZQ9 4KOX |
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| estradiol cypionate | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | None | 1979-08-15 FDA | |
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| ergocalciferol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) Vitamin D 25-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: Q6VVX0, gene: CYP2R1, swissprot: CP2R1_HUMAN) 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: O15528, gene: CYP27B1, swissprot: CP27B_HUMAN) | None | Ergocalciferols (Code: N0000006337) Provitamin D2 Compound (Code: N0000175909) nutraceutical (Code: CHEBI:50733) bone density conservation agent (Code: CHEBI:50646) rodenticide (Code: CHEBI:33288) | 1941-01-11 FDA | 3CZH |
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| diiodohydroxyquinoline | Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) | One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide. | Amebicides (Code: D000563) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | None FDA | |
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| pancuronium | Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release. | Neuromuscular Nondepolarizing Blockade (Code: N0000175732) Nondepolarizing Neuromuscular Blocker (Code: N0000175720) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) nicotinic antagonist (Code: CHEBI:48878) cholinergic antagonist (Code: CHEBI:48873) muscle relaxant (Code: CHEBI:51371) | 1972-10-24 FDA | |
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| cefetamet | active against Neisseria gonorrhoeae; structure given in first source | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| diperodon | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | None | |
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| drotaverine | Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) | Hungarian drug; RN given refers to parent cpd; structure | Analgesics (Code: D000700) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Vasodilator Agents (Code: D014665) | |
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| sulconazole | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Malate dehydrogenase cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P40925, gene: MDH1, swissprot: MDHC_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Homo sapiens, class: Enzyme, accessions: P05186, gene: ALPL, swissprot: PPBT_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | None | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1985-08-30 FDA | |
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| melarsoprol | Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects. | Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Trypanocidal Agents (Code: D014344) | |
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| sulfasalazine | Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Caspase-1 (Organism: Homo sapiens, class: Enzyme, accessions: P29466, gene: CASP1, swissprot: CASP1_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Acetyl-CoA acetyltransferase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P24752, gene: ACAT1, swissprot: THIL_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Cystine/glutamate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q9UPY5, gene: SLC7A11, swissprot: XCT_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Cyclooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P23219|P35354, gene: PTGS1|PTGS2, swissprot: PGH1_HUMAN|PGH2_HUMAN) Proton-coupled folate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q96NT5, gene: SLC46A1, swissprot: PCFT_HUMAN) | A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907) | Aminosalicylate (Code: N0000175781) Aminosalicylic Acids (Code: N0000005760) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antiinfective agent (Code: CHEBI:35441) gastrointestinal drug (Code: CHEBI:55324) | 1950-06-20 FDA | 13GS 4J7X 5ACL |
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| camostat | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Trypsin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P07477, gene: PRSS1, swissprot: TRY1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Plasminogen (Organism: Rattus norvegicus, class: Enzyme, accessions: Q01177, gene: Plg, swissprot: PLMN_RAT) Kallikrein-1 (Organism: Homo sapiens, class: Enzyme, accessions: P06870, gene: KLK1, swissprot: KLK1_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Hepatocyte growth factor activator (Organism: Homo sapiens, class: Enzyme, accessions: Q04756, gene: HGFAC, swissprot: HGFA_HUMAN) | None | Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) Trypsin Inhibitors (Code: D014361) | |
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| bisantrene | NAD(P)H dehydrogenase [quinone] 1 (Organism: Homo sapiens, class: Enzyme, accessions: P15559, gene: NQO1, swissprot: NQO1_HUMAN) | None | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) antineoplastic agent (Code: CHEBI:35610) | |
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| sunitinib | Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myosin-IIIb (Organism: Homo sapiens, class: Kinase, accessions: Q8WXR4, gene: MYO3B, swissprot: MYO3B_HUMAN) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Protein kinase C theta type (Organism: Homo sapiens, class: Kinase, accessions: Q04759, gene: PRKCQ, swissprot: KPCT_HUMAN) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) Muscle, skeletal receptor tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: O15146, gene: MUSK, swissprot: MUSK_HUMAN) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Organism: Homo sapiens, class: Kinase, accessions: P48736, gene: PIK3CG, swissprot: PK3CG_HUMAN) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Gallus gallus, class: Kinase, accessions: P00523, gene: SRC, swissprot: SRC_CHICK) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) Calcium/calmodulin-dependent protein kinase type IV (Organism: Homo sapiens, class: Kinase, accessions: Q16566, gene: CAMK4, swissprot: KCC4_HUMAN) Serine/threonine-protein kinase BRSK1 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDC3, gene: BRSK1, swissprot: BRSK1_HUMAN) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92630, gene: DYRK2, swissprot: DYRK2_HUMAN) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Serine/threonine-protein kinase PAK 3 (Organism: Homo sapiens, class: Kinase, accessions: O75914, gene: PAK3, swissprot: PAK3_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit beta (Organism: Homo sapiens, class: Kinase, accessions: Q13554, gene: CAMK2B, swissprot: KCC2B_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) MAP/microtubule affinity-regulating kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27448, gene: MARK3, swissprot: MARK3_HUMAN) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) Serine/threonine-protein kinase NIM1 (Organism: Homo sapiens, class: Kinase, accessions: Q8IY84, gene: NIM1K, swissprot: NIM1_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) Mitogen-activated protein kinase kinase kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q6ZN16, gene: MAP3K15, swissprot: M3K15_HUMAN) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) Casein kinase I isoform delta (Organism: Homo sapiens, class: Kinase, accessions: P48730, gene: CSNK1D, swissprot: KC1D_HUMAN) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) Serine/threonine-protein kinase pim-3 (Organism: Homo sapiens, class: Kinase, accessions: Q86V86, gene: PIM3, swissprot: PIM3_HUMAN) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) Serine/threonine-protein kinase BRSK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IWQ3, gene: BRSK2, swissprot: BRSK2_HUMAN) U4/U6 small nuclear ribonucleoprotein Prp4 (Organism: Homo sapiens, class: Unclassified, accessions: O43172, gene: PRPF4, swissprot: PRP4_HUMAN) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) Serine/threonine-protein kinase ICK (Organism: Homo sapiens, class: Kinase, accessions: Q9UPZ9, gene: ICK, swissprot: ICK_HUMAN) Serine/threonine-protein kinase Nek7 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDX7, gene: NEK7, swissprot: NEK7_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) Serine/threonine-protein kinase/endoribonuclease IRE1 (Organism: Homo sapiens, class: Kinase, accessions: O75460, gene: ERN1, swissprot: ERN1_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) MAP/microtubule affinity-regulating kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96L34, gene: MARK4, swissprot: MARK4_HUMAN) Serine/threonine-protein kinase OSR1 (Organism: Homo sapiens, class: Kinase, accessions: O95747, gene: OXSR1, swissprot: OXSR1_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) Serine/threonine-protein kinase Sgk3 (Organism: Homo sapiens, class: Kinase, accessions: Q96BR1, gene: SGK3, swissprot: SGK3_HUMAN) STE20/SPS1-related proline-alanine-rich protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UEW8, gene: STK39, swissprot: STK39_HUMAN) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) Myosin light chain kinase family member 4 (Organism: Homo sapiens, class: Kinase, accessions: Q86YV6, gene: MYLK4, swissprot: MYLK4_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) Serine/threonine-protein kinase tousled-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q86UE8, gene: TLK2, swissprot: TLK2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: Q13555, gene: CAMK2G, swissprot: KCC2G_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) Serine/threonine-protein kinase MARK2 (Organism: Homo sapiens, class: Kinase, accessions: Q7KZI7, gene: MARK2, swissprot: MARK2_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) Myosin light chain kinase, smooth muscle (Organism: Gallus gallus, class: Kinase, accessions: P11799, gene: Mylk, swissprot: MYLK_CHICK) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Serine/threonine-protein kinase 38 (Organism: Homo sapiens, class: Kinase, accessions: Q15208, gene: STK38, swissprot: STK38_HUMAN) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) Casein kinase I isoform gamma-1 (Organism: Homo sapiens, class: Kinase, accessions: Q9HCP0, gene: CSNK1G1, swissprot: KC1G1_HUMAN) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) Ribosomal protein S6 kinase alpha-3 (Organism: Homo sapiens, class: Kinase, accessions: P51812, gene: RPS6KA3, swissprot: KS6A3_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Myosin-IIIa (Organism: Homo sapiens, class: Kinase, accessions: Q8NEV4, gene: MYO3A, swissprot: MYO3A_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) Serine/threonine-protein kinase 25 (Organism: Homo sapiens, class: Kinase, accessions: O00506, gene: STK25, swissprot: STK25_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Mus musculus, class: Kinase, accessions: Q3U3Q1, gene: Ulk3, swissprot: ULK3_MOUSE) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Serine/threonine-protein kinase 38-like (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H1, gene: STK38L, swissprot: ST38L_HUMAN) Serine/threonine-protein kinase DCLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8N568, gene: DCLK2, swissprot: DCLK2_HUMAN) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Casein kinase I isoform alpha-like (Organism: Homo sapiens, class: Kinase, accessions: Q8N752, gene: CSNK1A1L, swissprot: KC1AL_HUMAN) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) Serine/threonine-protein kinase PAK 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9NQU5, gene: PAK6, swissprot: PAK6_HUMAN) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Insulin receptor-related protein (Organism: Homo sapiens, class: Kinase, accessions: P14616, gene: INSRR, swissprot: INSRR_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) Serine/threonine-protein kinase pim-2 (Organism: Homo sapiens, class: Kinase, accessions: Q9P1W9, gene: PIM2, swissprot: PIM2_HUMAN) Serine/threonine-protein kinase PAK 7 (Organism: Homo sapiens, class: Kinase, accessions: Q9P286, gene: PAK5, swissprot: PAK5_HUMAN) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) Megakaryocyte-associated tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P42679, gene: MATK, swissprot: MATK_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Death-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UIK4, gene: DAPK2, swissprot: DAPK2_HUMAN) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) Serine/threonine-protein kinase 3 (Organism: Mus musculus, class: Kinase, accessions: Q9JI10, gene: Stk3, swissprot: STK3_MOUSE) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) Protein-tyrosine kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q13882, gene: PTK6, swissprot: PTK6_HUMAN) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) Calcium/calmodulin-dependent protein kinase type 1G (Organism: Homo sapiens, class: Kinase, accessions: Q96NX5, gene: CAMK1G, swissprot: KCC1G_HUMAN) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) Serine/threonine-protein kinase Nek2 (Organism: Homo sapiens, class: Kinase, accessions: P51955, gene: NEK2, swissprot: NEK2_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) RAC-beta serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31751, gene: AKT2, swissprot: AKT2_HUMAN) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) Serine/threonine-protein kinase STK11 (Organism: Homo sapiens, class: Kinase, accessions: Q15831, gene: STK11, swissprot: STK11_HUMAN) Rhodopsin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q15835, gene: GRK1, swissprot: RK_HUMAN) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Serine/threonine-protein kinase MARK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9P0L2, gene: MARK1, swissprot: MARK1_HUMAN) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) Serine/threonine-protein kinase PLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NYY3, gene: PLK2, swissprot: PLK2_HUMAN) Bone morphogenetic protein receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: Q13873, gene: BMPR2, swissprot: BMPR2_HUMAN) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Serine/threonine-protein kinase LATS2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRM7, gene: LATS2, swissprot: LATS2_HUMAN) Inhibitor of nuclear factor kappa-B kinase subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: O15111, gene: CHUK, swissprot: IKKA_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Organism: Homo sapiens, class: Kinase, accessions: Q9Y463, gene: DYRK1B, swissprot: DYR1B_HUMAN) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) Serine/threonine-protein kinase PRP4 homolog (Organism: Homo sapiens, class: Kinase, accessions: Q13523, gene: PRPF4B, swissprot: PRP4B_HUMAN) SNF-related serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NRH2, gene: SNRK, swissprot: SNRK_HUMAN) Dual serine/threonine and tyrosine protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q6XUX3, gene: DSTYK, swissprot: DUSTY_HUMAN) Serine/threonine-protein kinase PknB (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WI81, gene: pknB, swissprot: PKNB_MYCTU) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Casein kinase I isoform alpha (Organism: Homo sapiens, class: Kinase, accessions: P48729, gene: CSNK1A1, swissprot: KC1A_HUMAN) Tankyrase-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9H2K2, gene: TNKS2, swissprot: TNKS2_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Serine/threonine-protein kinase 24 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6E0, gene: STK24, swissprot: STK24_HUMAN) Casein kinase I isoform gamma-3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6M4, gene: CSNK1G3, swissprot: KC1G3_HUMAN) Death-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53355, gene: DAPK1, swissprot: DAPK1_HUMAN) 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: P54646, gene: PRKAA2, swissprot: AAPK2_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) Uncharacterized serine/threonine-protein kinase SBK3 (Organism: Homo sapiens, class: Kinase, accessions: P0C264, gene: SBK3, swissprot: SBK3_HUMAN) Hormonally up-regulated neu tumor-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: P57058, gene: HUNK, swissprot: HUNK_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Cyclin-dependent kinase 17 (Organism: Homo sapiens, class: Kinase, accessions: Q00537, gene: CDK17, swissprot: CDK17_HUMAN) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) Serine/threonine-protein kinase PAK 4 (Organism: Homo sapiens, class: Kinase, accessions: O96013, gene: PAK4, swissprot: PAK4_HUMAN) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) Cyclin-dependent kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: O94921, gene: CDK14, swissprot: CDK14_HUMAN) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Cyclin-dependent kinase 18 (Organism: Homo sapiens, class: Kinase, accessions: Q07002, gene: CDK18, swissprot: CDK18_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) Serine/threonine-protein kinase LATS1 (Organism: Homo sapiens, class: Kinase, accessions: O95835, gene: LATS1, swissprot: LATS1_HUMAN) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Organism: Homo sapiens, class: Kinase, accessions: P78356, gene: PIP4K2B, swissprot: PI42B_HUMAN) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) Serine/threonine-protein kinase D2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZL6, gene: PRKD2, swissprot: KPCD2_HUMAN) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) Protein delta homolog 1 (Organism: Homo sapiens, class: Unclassified, accessions: P80370, gene: DLK1, swissprot: DLK1_HUMAN) SRSF protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P78362, gene: SRPK2, swissprot: SRPK2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) Serine/threonine-protein kinase tousled-like 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UKI8, gene: TLK1, swissprot: TLK1_HUMAN) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) Dual specificity mitogen-activated protein kinase kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: P52564, gene: MAP2K6, swissprot: MP2K6_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Cyclin-dependent-like kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q00535, gene: CDK5, swissprot: CDK5_HUMAN) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) Serine/threonine-protein kinase RIO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BVS4, gene: RIOK2, swissprot: RIOK2_HUMAN) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) Casein kinase I isoform gamma-2 (Organism: Homo sapiens, class: Kinase, accessions: P78368, gene: CSNK1G2, swissprot: KC1G2_HUMAN) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit delta (Organism: Homo sapiens, class: Kinase, accessions: Q13557, gene: CAMK2D, swissprot: KCC2D_HUMAN) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) Protein kinase C alpha type (Organism: Homo sapiens, class: Kinase, accessions: P17252, gene: PRKCA, swissprot: KPCA_HUMAN) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) Mitogen-activated protein kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q13164, gene: MAPK7, swissprot: MK07_HUMAN) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Ephrin type-A receptor 7 (Organism: Homo sapiens, class: Kinase, accessions: Q15375, gene: EPHA7, swissprot: EPHA7_HUMAN) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) | inhibits VEGF-R2 and PDGF-Rbeta tyrosine kinase; has antineoplastic activity | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) angiogenesis inhibitor (Code: CHEBI:48422) antineoplastic agent (Code: CHEBI:35610) immunomodulator (Code: CHEBI:50846) neuroprotective agent (Code: CHEBI:63726) | 2006-07-19 EMA 2006-01-26 FDA | 2Y7J 3G0E 3G0F 3MIY 3TI1 4AGD 4KS8 4QMZ |
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| bemetizide | None | |
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| flutropium | None | |
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| beraprost | Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostacyclin receptor (Organism: Mus musculus, class: Unclassified, accessions: P43252, gene: Ptgir, swissprot: PI2R_MOUSE) Prostacyclin receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P43253, gene: Ptgir, swissprot: PI2R_RAT) | stable prostacyclin analog; structure given in first source | Cardiovascular Agents (Code: D002317) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) Vasodilator Agents (Code: D014665) | 1992-01-01 YEAR INTRODUCED | |
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| pholcodine | None | Analgesics (Code: D000700) Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) antitussive (Code: CHEBI:51177) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) | |
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| dimorpholamine | analeptic properties; minor descriptor (75-83); on-line & Index Medicus search MORPHOLINES (75-83); structure | None PMDA | |
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| pipazetate | None | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| pentagestrone | None | |
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| dihydrotachysterol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | A VITAMIN D that can be regarded as a reduction product of vitamin D2. | Bone Density Conservation Agents (Code: D050071) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) bone density conservation agent (Code: CHEBI:50646) | |
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| colchicine | Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Glycine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P23416, gene: GLRA2, swissprot: GLRA2_HUMAN) Tubulin beta-4B chain (Organism: Homo sapiens, class: Structural, accessions: P68371, gene: TUBB4B, swissprot: TBB4B_HUMAN) Tubulin (Organism: Sus scrofa, class: Structural, accessions: P02550|P02554, gene: TUBA1A, swissprot: TBA1A_PIG|TBB_PIG) Tubulin alpha-1A chain (Organism: Sus scrofa, class: Structural, accessions: P02550, gene: TUBA1A, swissprot: TBA1A_PIG) Tubulin beta-2B chain (Organism: Bos taurus, class: Structural, accessions: Q6B856, gene: TUBB2B, swissprot: TBB2B_BOVIN) Tubulin (Organism: Bos taurus, class: Structural, accessions: Q6B856|Q862F3|Q862L2, gene: TUBB2B, swissprot: Q862F3_BOVIN|Q862L2_BOVIN|TBB2B_BOVIN) Tubulin polymerization-promoting protein (Organism: Bos taurus, class: Unclassified, accessions: Q27957, gene: TPPP, swissprot: TPPP_BOVIN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Tubulin beta chain (Organism: Homo sapiens, class: Structural, accessions: P07437, gene: TUBB, swissprot: TBB5_HUMAN) | A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE). | Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Interactions (Code: N0000000239) Antimitotic Agents (Code: D050256) Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) | 1961-07-27 FDA | 3E22 3UT5 4LZR 4O2B 4X1I 4X1K 4X1Y 4X20 5EYP 5ITZ 5MIO 5NKN 5NM5 |
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| ademetionine | Phenylethanolamine N-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P11086, gene: PNMT, swissprot: PNMT_HUMAN) Protein-beta-aspartate methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P22061, gene: PCMT1, swissprot: PIMT_HUMAN) S-adenosylmethionine decarboxylase proenzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P17708, gene: Amd1, swissprot: DCAM_RAT) Protein arginine N-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q99873, gene: PRMT1, swissprot: ANM1_HUMAN) Met repressor (Organism: Escherichia coli, class: Unclassified, accessions: C3SIU2, gene: metJ, swissprot: C3SIU2_ECOLX) | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) | |
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| thiethylperazine | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) phenothiazine antipsychotic drug (Code: CHEBI:37930) histamine antagonist (Code: CHEBI:37956) muscarinic antagonist (Code: CHEBI:48876) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) antiemetic (Code: CHEBI:50919) | 1961-07-18 FDA | |
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| mepacrine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Bacterial DNA-directed RNA polymerase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A7Z4|P0A800|P0A8T7|P0A8V2, gene: rpoA|rpoB|rpoC|rpoZ, swissprot: RPOA_ECOLI|RPOB_ECOLI|RPOC_ECOLI|RPOZ_ECOLI) Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) Phospholipase A2 group 1B (Organism: Rattus norvegicus, class: Unclassified, accessions: P04055, gene: Pla2g1b, swissprot: PA21B_RAT) Phospholipase A2 group 1B (Organism: Sus scrofa, class: Enzyme, accessions: P00592, gene: PLA2G1B, swissprot: PA21B_PIG) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) Riboflavin-binding protein (Organism: Gallus gallus, class: Unclassified, accessions: P02752, gene: None, swissprot: RBP_CHICK) Cyclooxygenase (Organism: Bos taurus, class: Enzyme, accessions: O62664|O62698, gene: PTGS1|PTGS2, swissprot: PGH1_BOVIN|PGH2_BOVIN) | An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anticestodal Agents (Code: D000923) Antimalarials (Code: D000962) Antinematodal Agents (Code: D000969) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) antimalarial (Code: CHEBI:38068) | 1933-01-01 YEAR INTRODUCED | 1JQE |
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| enprostil | Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P34980, gene: Ptger3, swissprot: PE2R3_RAT) Prostaglandin E2 receptor EP1 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P70597, gene: Ptger1, swissprot: PE2R1_RAT) | A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers. | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | 1985-01-01 YEAR INTRODUCED | |
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| fominoben | was MH 1975-92 (see under MORPHOLINES 1975-90); use MORPHOLINES to search FOMINOBEN 1975-92 | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) | |
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| fursultiamine | Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vitamin B Complex (Code: D014803) | |
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| beta-Ergocryptine | None | |
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| tiocarlide | Epoxide hydrolase EphE; Hydrolase, alpha/beta hydrolase fold family (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: O69638, gene: None, swissprot: O69638_MYCTO) | major descriptor (68-85); on-line search PHENYLTHIOUREA/AA (68-85); Index Medicus search THIOCARLIDE (68-85); Antitubercular Agent | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) | |
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| gefarnate | A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue. | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| calcifediol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | Bone Density Conservation Agents (Code: D050071) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) bone density conservation agent (Code: CHEBI:50646) nutraceutical (Code: CHEBI:50733) | 1980-08-05 FDA | 1J78 1MZ9 3A51 5IEN 5IEO 5IEP |
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| alfacalcidol | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | None | Bone Density Conservation Agents (Code: D050071) bone density conservation agent (Code: CHEBI:50646) | 1978-01-01 YEAR INTRODUCED | |
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| mometasone furoate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Allergic Agents (Code: D018926) Anti-Inflammatory Agents (Code: D000893) Dermatologic Agents (Code: D003879) anti-inflammatory drug (Code: CHEBI:35472) anti-allergic agent (Code: CHEBI:50857) | 1987-04-30 FDA | 1SR7 4E2J 4P6W |
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| zuclopenthixol | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) | Zuclopenthixol is a potent neuroleptic of the thioxanthene series with a piperazine side-chain. The antipsychotic effect of neuroleptics is related to their dopamine receptor blocking effect. The thioxanthenes have a high affinity for both the adenylate cyclase coupled dopamine D1 receptors and for the dopamine D2 receptors; in the phenothiazine group the affinity for D1 receptors is much lower than that for D2 receptors, whereas butyrophenones, diphenylbutylpiperidines and benzamides only have affinity for D2 receptors. | dopaminergic antagonist (Code: CHEBI:48561) alpha-adrenergic antagonist (Code: CHEBI:37890) serotonergic antagonist (Code: CHEBI:48279) H1-receptor antagonist (Code: CHEBI:37955) first generation antipsychotic (Code: CHEBI:65190) | None UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| oxyphenisatine acetate | A laxative that undergoes enterohepatic circulation. It may cause jaundice. | Cathartics (Code: D002400) Gastrointestinal Agents (Code: D005765) | |
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| moxifloxacin | DNA topoisomerase 4 subunit A (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0C1U9, gene: parC, swissprot: PARC_STAAU) DNA gyrase subunit A (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WG47, gene: gyrA, swissprot: GYRA_MYCTU) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) Topoisomerase IV (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2|P20083, gene: parC|parE, swissprot: PARC_ECOLI|PARE_ECOLI) | None | Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) | 1999-12-10 FDA | 2XKK 3FOF 4Z2C 4Z3O 5BS8 5BTA 5CDQ |
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| oxacillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCR9, gene: PDE11A, swissprot: PDE11_HUMAN) Penicillin-binding protein (Organism: Staphylococcus aureus, class: Enzyme, accessions: P72355|Q53707|Q53725|Q53729|Q9XDB3, gene: PBP2|mecA|pbp4|pbpA|pbpF, swissprot: P72355_STAAU|Q53707_STAAU|Q53725_STAAU|Q53729_STAAU|Q9XDB3_STAAU) | An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1971-04-08 FDA | |
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| amperozide | 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Fatty-acid amide hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O00519, gene: FAAH, swissprot: FAAH1_HUMAN) | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) | |
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| pipamazine | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | None | |
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| prednisolone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Anti-Inflammatory Agents (Code: D000893) | 1955-05-22 FDA | |
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| cinitapride | None | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| dehydrocholic acid | A semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid. | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) gastrointestinal drug (Code: CHEBI:55324) | |
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| ethinylestradiol sulfonate | None | |
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| sulforidazine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | Antidepressive Agents (Code: D000928) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| metergoline | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) | A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy. | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) serotonergic antagonist (Code: CHEBI:48279) dopamine agonist (Code: CHEBI:51065) | |
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| tipranavir | Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Cathepsin D (Organism: Homo sapiens, class: Enzyme, accessions: P07339, gene: CTSD, swissprot: CATD_HUMAN) Pepsin A-5 (Organism: Homo sapiens, class: Enzyme, accessions: P0DJD9, gene: PGA5, swissprot: PEPA5_HUMAN) Cathepsin E (Organism: Homo sapiens, class: Enzyme, accessions: P14091, gene: CTSE, swissprot: CATE_HUMAN) CAAX prenyl protease 1 homolog (Organism: Mus musculus, class: Enzyme, accessions: Q80W54, gene: Zmpste24, swissprot: FACE1_MOUSE) | Tipranavir is an HIV-1 protease inhibitor that inhibits the virus-specific processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions. | HIV Protease Inhibitors (Code: N0000000246) Protease Inhibitor (Code: N0000175889) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) antiviral drug (Code: CHEBI:36044) | 2005-06-22 FDA | 1D4S 1D4Y 2O4L 2O4N 2O4P 3SPK 4NJU |
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| delmadinone acetate | None | Androgen Antagonists (Code: D000726) Hormone Antagonists (Code: D006727) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) | |
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| lorajmine | A monochloroacetyl derivative of ajmaline. It is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| clocinizine | None | |
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| roflumilast | Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Organism: Homo sapiens, class: Enzyme, accessions: Q08499, gene: PDE4D, swissprot: PDE4D_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) | None | Phosphodiesterase 4 Inhibitor (Code: N0000182961) Phosphodiesterase 4 Inhibitors (Code: N0000182960) anti-asthmatic drug (Code: CHEBI:49167) | 2011-02-28 EMA 2011-02-28 FDA | 1XMU 1XOQ 3G4L |
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| phthalylsulfathiazole | minor descriptor (63-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd | |
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| aminoxytriphene | None | |
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| perphenazine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) | An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) dopaminergic antagonist (Code: CHEBI:48561) antiemetic (Code: CHEBI:50919) phenothiazine antipsychotic drug (Code: CHEBI:37930) | 1957-02-27 FDA | |
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| alpidem | Translocator protein (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P16257, gene: Tspo, swissprot: TSPO_RAT) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1991-01-01 YEAR INTRODUCED | |
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| tosufloxacin | quinolone anti-infective agent; structure given in first source | antiinfective agent (Code: CHEBI:35441) | |
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| bentiromide | chymotrypsin labile peptide used diagnostically as an index of exocrine pancreas function | Indicators and Reagents (Code: D007202) reagent (Code: CHEBI:33893) indicator (Code: CHEBI:47867) diagnostic agent (Code: CHEBI:33295) | 1983-12-29 FDA | |
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| nicocodine | None | |
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| aldesulfone | Glucose-6-phosphate 1-dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P11413, gene: G6PD, swissprot: G6PD_HUMAN) Dihydropteroate synthase 1 (Organism: Mycobacterium leprae (strain TN), class: Enzyme, accessions: P0C0X1, gene: folP1, swissprot: DHPS1_MYCLE) | None | 1974-05-24 FDA | |
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| sulfinpyrazone | fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Solute carrier family 22 member 12 (Organism: Homo sapiens, class: Transporter, accessions: Q96S37, gene: SLC22A12, swissprot: S22AC_HUMAN) | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) uricosuric drug (Code: CHEBI:35841) | 1959-05-13 FDA | |
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| flunarizine | Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1I (Organism: Homo sapiens, class: Ion channel, accessions: Q9P0X4, gene: CACNA1I, swissprot: CAC1I_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) Voltage-dependent N-type calcium channel subunit alpha-1B (Organism: Homo sapiens, class: Ion channel, accessions: Q00975, gene: CACNA1B, swissprot: CAC1B_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) CAAX prenyl protease 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y256, gene: RCE1, swissprot: FACE2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) CAAX prenyl protease 2 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: Q03530, gene: RCE1, swissprot: RCE1_YEAST) | Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. | Anticonvulsants (Code: D000927) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | |
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| benzquinamide | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | antiemetic (Code: CHEBI:50919) sedative (Code: CHEBI:35717) H1-receptor antagonist (Code: CHEBI:37955) muscarinic antagonist (Code: CHEBI:48876) antipsychotic agent (Code: CHEBI:35476) | 1974-03-12 FDA | |
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| lovastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) Hydroxycarboxylic acid receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P49019, gene: HCAR3, swissprot: HCAR3_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) Leukocyte adhesion glycoprotein LFA-1 alpha (Organism: Homo sapiens, class: Adhesion, accessions: P20701, gene: ITGAL, swissprot: ITAL_HUMAN) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Mus musculus, class: Enzyme, accessions: Q01237, gene: Hmgcr, swissprot: HMDH_MOUSE) Acyl-CoA:cholesterol acyltransferase (Organism: Oryctolagus cuniculus, class: Unclassified, accessions: Q95214, gene: ACAT, swissprot: Q95214_RABIT) | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) prodrug (Code: CHEBI:50266) anticholesteremic drug (Code: CHEBI:35821) antineoplastic agent (Code: CHEBI:35610) | 1987-08-31 FDA | 1CQP |
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| mepitiostane | orally active anti-estrogenic steroid; RN refers to (2alpha,3alpha,5alpha,17beta)-isomer; structure | Anabolic Agents (Code: D045930) Antineoplastic Agents (Code: D000970) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| chlormadinone | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | An orally active synthetic progestational hormone used often in combinations as an oral contraceptive. | Androgen Antagonists (Code: D000726) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) | |
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| taltirelin | Thyrotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P34981, gene: TRHR, swissprot: TRFR_HUMAN) | None | Central Nervous System Agents (Code: D002491) Nootropic Agents (Code: D018697) | |
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| cefaloglycin | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A cephalorsporin antibiotic. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1970-06-12 FDA | |
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| nebivolol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) | A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-1 Receptor Agonists (Code: D058665) Adrenergic beta-Agonists (Code: D000318) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Adrenergic beta-Antagonists (Code: N0000000161) beta-Adrenergic Blocker (Code: N0000175556) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) beta-adrenergic antagonist (Code: CHEBI:35530) vasodilator agent (Code: CHEBI:35620) antihypertensive agent (Code: CHEBI:35674) | 2007-12-17 FDA | |
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| hexachlorophene | D-lactate dehydrogenase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P06149, gene: dld, swissprot: DLD_ECOLI) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AEK4, gene: fabI, swissprot: FABI_ECOLI) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Transitional endoplasmic reticulum ATPase (Organism: Homo sapiens, class: Enzyme, accessions: P55072, gene: VCP, swissprot: TERA_HUMAN) Heat shock cognate 71 kDa protein (Organism: Homo sapiens, class: Unclassified, accessions: P11142, gene: HSPA8, swissprot: HSP7C_HUMAN) Heat shock 70 kDa protein 1A (Organism: Homo sapiens, class: Unclassified, accessions: P0DMV8, gene: HSPA1A, swissprot: HS71A_HUMAN) Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) Envelope glycoprotein gp160 (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q6QLK5, gene: env, swissprot: Q6QLK5_9HIV1) M1-family alanyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8IEK1, gene: None, swissprot: Q8IEK1_PLAF7) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) | Antiseptic (Code: N0000175486) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) antiseptic drug (Code: CHEBI:48218) acaricide (Code: CHEBI:22153) antifungal agrochemical (Code: CHEBI:86328) | 1949-04-19 FDA | 3ETE |
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| imidapril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1993-01-01 YEAR INTRODUCED | |
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| febarbamate | None | |
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| nifekalant | Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| lisinopril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) | One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure. | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) Protective Agents (Code: D020011) antihypertensive agent (Code: CHEBI:35674) | 1987-12-29 FDA | 1J36 1O86 2C6N 2X91 |
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| astromicin | None | |
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| mazaticol | None | |
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| morclofone | None | |
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| toremifene | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen-related receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P62508, gene: ESRRG, swissprot: ERR3_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) | A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. | Estrogen Agonist/Antagonist (Code: N0000175826) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Bone Density Conservation Agents (Code: D050071) Estrogen Receptor Modulators (Code: D020847) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Selective Estrogen Receptor Modulators (Code: D020845) antineoplastic agent (Code: CHEBI:35610) estrogen antagonist (Code: CHEBI:50837) bone density conservation agent (Code: CHEBI:50646) estrogen receptor modulator (Code: CHEBI:50739) | 1997-05-29 FDA | 5JQ7 |
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| clomifene | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) | A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively. | Estrogen Agonist/Antagonist (Code: N0000175826) Estrogen Antagonists (Code: D004965) Estrogen Receptor Modulators (Code: D020847) Fertility Agents (Code: D005299) Fertility Agents, Female (Code: D005300) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) Selective Estrogen Receptor Modulators (Code: D020845) anti-estrogen (Code: CHEBI:50751) | 1967-02-01 FDA | |
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| floctafenine | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| penamecillin | None | antibacterial drug (Code: CHEBI:36047) prodrug (Code: CHEBI:50266) | |
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| carvedilol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) Amyloid beta A4 protein (Organism: Homo sapiens, class: Unclassified, accessions: P05067, gene: APP, swissprot: A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | antioxidant with alpha as well as beta blocking activity | Adrenergic beta1-Antagonists (Code: N0000009923) Adrenergic beta2-Antagonists (Code: N0000009924) alpha-Adrenergic Blocker (Code: N0000175553) beta-Adrenergic Blocker (Code: N0000175556) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) cardiovascular drug (Code: CHEBI:35554) beta-adrenergic antagonist (Code: CHEBI:35530) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic antagonist (Code: CHEBI:37890) | 1995-09-14 FDA | 4AMJ |
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| alacepril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) | 1988-01-01 YEAR INTRODUCED | |
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| lincomycin | 50S ribosomal protein L10 (Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809), class: Ribosomal protein, accessions: P15825, gene: rpl10, swissprot: RL10_HALMA) | An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1964-12-29 FDA | 4WH5 5HKV |
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| nandrolone phenpropionate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | None | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1959-10-30 FDA | |
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| sitagliptin | Dipeptidyl peptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UHL4, gene: DPP7, swissprot: DPP2_HUMAN) Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Dipeptidyl peptidase 4 (Organism: Mus musculus, class: Enzyme, accessions: P28843, gene: Dpp4, swissprot: DPP4_MOUSE) Dipeptidyl peptidase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q6V1X1, gene: DPP8, swissprot: DPP8_HUMAN) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) Prolyl endopeptidase FAP (Organism: Homo sapiens, class: Enzyme, accessions: Q12884, gene: FAP, swissprot: SEPR_HUMAN) | A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES. | Dipeptidyl Peptidase 4 Inhibitor (Code: N0000175913) Dipeptidyl Peptidase 4 Inhibitors (Code: N0000175912) Dipeptidyl-Peptidase IV Inhibitors (Code: D054873) Enzyme Inhibitors (Code: D004791) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Hypoglycemic Agents (Code: D007004) Incretins (Code: D054795) Protease Inhibitors (Code: D011480) hypoglycemic agent (Code: CHEBI:35526) | 2006-10-16 FDA | 1X70 4FFW |
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| trifluoperazine | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Emopamil-binding protein-like (Organism: Homo sapiens, class: Unclassified, accessions: Q9BY08, gene: EBPL, swissprot: EBPL_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) NS3 (Organism: Hepatitis C virus, class: Enzyme, accessions: A3EZI9, gene: NS3, swissprot: A3EZI9_9HEPC) DNA-dependent protein kinase catalytic subunit (Organism: Homo sapiens, class: Kinase, accessions: P78527, gene: PRKDC, swissprot: PRKDC_HUMAN) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Beta-glucuronidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P06760, gene: Gusb, swissprot: BGLR_RAT) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Lysozyme C-1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P00697, gene: Lyz1, swissprot: LYSC1_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) dopaminergic antagonist (Code: CHEBI:48561) antiemetic (Code: CHEBI:50919) phenothiazine antipsychotic drug (Code: CHEBI:37930) | 1959-04-16 FDA | 1A29 1CTR 1LIN 1WRK 1WRL 3KO0 4RJD |
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| bidisomide | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| ethyl biscoumacetate | Vitamin K epoxide reductase complex subunit 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BQB6, gene: VKORC1, swissprot: VKOR1_HUMAN) | A coumarin that is used as an anticoagulant. It has actions similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226) | Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | |
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| tamsulosin | Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) | an alpha 1 adrenoreceptor blocker | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) antineoplastic agent (Code: CHEBI:35610) alpha-adrenergic antagonist (Code: CHEBI:37890) | 1997-04-15 FDA | |
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| omapatrilat | Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Neprilysin (Organism: Homo sapiens, class: Enzyme, accessions: P08473, gene: MME, swissprot: NEP_HUMAN) Neprilysin (Organism: Rattus norvegicus, class: Enzyme, accessions: P07861, gene: Mme, swissprot: NEP_RAT) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) Vasopeptidase Inhibitors (Code: D000075563) | |
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| cholic acid | G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) | A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. | Bile Acid (Code: N0000175802) Bile Acids and Salts (Code: N0000006801) | 2015-03-17 FDA 2013-09-12 EMA | |
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| quingestanol acetate | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | None | |
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| miltefosine | RAC-alpha serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31749, gene: AKT1, swissprot: AKT1_HUMAN) Dual specificity phosphatase Cdc25A (Organism: Homo sapiens, class: Enzyme, accessions: P30304, gene: CDC25A, swissprot: MPIP1_HUMAN) | hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin | Antileishmanial (Code: N0000190851) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) immunomodulator (Code: CHEBI:50846) anti-inflammatory agent (Code: CHEBI:67079) antineoplastic agent (Code: CHEBI:35610) antiprotozoal drug (Code: CHEBI:35820) | 2014-03-19 FDA | |
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| levamlodipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | used to treat angina and hypertension | 5KMD |
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| amlodipine | Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Homo sapiens, class: Ion channel, accessions: P54289, gene: CACNA2D1, swissprot: CA2D1_HUMAN) | A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION. | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) | 1992-07-31 FDA | 3TMZ 3UA5 5KMD |
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| beclometasone dipropionate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Interleukin-5 (Organism: Homo sapiens, class: Cytokine, accessions: P05113, gene: IL5, swissprot: IL5_HUMAN) | An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Respiratory System Agents (Code: D019141) anti-asthmatic drug (Code: CHEBI:49167) prodrug (Code: CHEBI:50266) anti-arrhythmia drug (Code: CHEBI:38070) anti-inflammatory drug (Code: CHEBI:35472) | 1976-05-12 FDA | |
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| trifluperidol | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) | A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621) | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| ezetimibe | Niemann-Pick C1-like protein 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q6T3U3, gene: Npc1l1, swissprot: NPCL1_RAT) Niemann-Pick C1-like protein 1 (Organism: Homo sapiens, class: Membrane other, accessions: Q9UHC9, gene: NPC1L1, swissprot: NPCL1_HUMAN) | An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS. | Decreased Cholesterol Absorption (Code: N0000008553) Dietary Cholesterol Absorption Inhibitor (Code: N0000175911) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) anticholesteremic drug (Code: CHEBI:35821) antilipemic drug (Code: CHEBI:35679) | 2002-10-25 FDA | |
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| benexate | None | |
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| butaperazine | None | |
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| flecainide | Potassium voltage-gated channel subfamily A member 7 (Organism: Homo sapiens, class: Ion channel, accessions: Q96RP8, gene: KCNA7, swissprot: KCNA7_HUMAN) Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Potassium voltage-gated channel subfamily D member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63881, gene: Kcnd2, swissprot: KCND2_RAT) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Potassium voltage-gated channel subfamily C member 1 (Organism: Mus musculus, class: Unclassified, accessions: P15388, gene: Kcnc1, swissprot: KCNC1_MOUSE) | A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS. | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) anti-arrhythmia drug (Code: CHEBI:38070) | 1985-10-31 FDA | |
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| sitafloxacin | DNA gyrase subunit B (Organism: Escherichia coli O157:H7, class: Enzyme, accessions: P0AES7, gene: gyrB, swissprot: GYRB_ECO57) DNA topoisomerase 4 subunit A (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P72525, gene: parC, swissprot: PARC_STRPN) | Sitafloxacin hydrate is a fluoroquinolone antibiotic. It is indicated for the treatment of various infections such as respiratory infection, urologic infection, gynecologic infection, otorhinological infections, and dental infection. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 2008-01-25 PMDA | |
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| ceftibuten | Penicillin-binding protein (Organism: Streptococcus pyogenes serotype M4 (strain MGAS10750), class: Enzyme, accessions: Q1J5W5, gene: None, swissprot: Q1J5W5_STRPF) Penicillin-binding protein 3 (Organism: Haemophilus influenzae, class: Enzyme, accessions: Q60FU1, gene: pbp3, swissprot: Q60FU1_HAEIF) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | synthetic antibiotic; structure given in first source | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1995-12-20 FDA | |
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| risperidone | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) D(2) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: P61168, gene: Drd2, swissprot: DRD2_MOUSE) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 1A (Organism: Mus musculus, class: GPCR, accessions: Q64264, gene: Htr1a, swissprot: 5HT1A_MOUSE) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Serotonin 2 (5-HT2) receptor (Organism: Mus musculus, class: GPCR, accessions: P34968|P35363|Q02152, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_MOUSE|5HT2B_MOUSE|5HT2C_MOUSE) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA. | Atypical Antipsychotic (Code: N0000175430) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) dopaminergic antagonist (Code: CHEBI:48561) psychotropic drug (Code: CHEBI:35471) second generation antipsychotic (Code: CHEBI:65191) serotonergic antagonist (Code: CHEBI:48279) alpha-adrenergic antagonist (Code: CHEBI:37890) H1-receptor antagonist (Code: CHEBI:37955) | 1993-12-29 FDA | 6CM4 |
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| cinepazide | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| ornoprostil | None | |
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| methestrol dipropionate | None | |
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| piperacetazine | was MH 1975-91 (see under PHENOTHIAZINE TRANQUILIZERS 1975-90) | 1969-02-03 FDA | |
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| norethindrone enanthate | None | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Reproductive Control Agents (Code: D012102) | |
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| iomazenil (123I) | potential benzodiazepine receptor imaging tracer for SPECT; structure given in first source; RN given refers to 123I-labeled cpd; RN for unlabeled cpd not avail 10/90 | |
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| tasosartan | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Angiotensin II receptor (AT-1) type-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089, gene: Agtr1|Agtr1b, swissprot: AGTRA_RAT|AGTRB_RAT) | angiotensin II antagonist; structure given in first source | Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) | |
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| fluvastatin | Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) | a once-a-day oral medication for the treatment of high blood cholesterol (hypercholesterolemia) in patients who do not respond to diet alone | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) anticholesteremic drug (Code: CHEBI:35821) | 1993-12-31 FDA | |
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| acetophenazine | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) | major descriptor (73-85); minor descriptor (64-72); on-line search PHENOTHIAZINES (64-85); Index Medicus search PHENOTHIAZINES (64-72); ACETOPHENAZINE (73-85); RN given refers to parent cpd | phenothiazine antipsychotic drug (Code: CHEBI:37930) | 1961-04-05 FDA | |
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| butoconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) | None | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1995-12-21 FDA | |
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| reserpiline | None | |
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| adapalene | Retinoic acid receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10276, gene: RARA, swissprot: RARA_HUMAN) Retinoic acid receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P13631, gene: RARG, swissprot: RARG_HUMAN) Retinoic acid receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10826, gene: RARB, swissprot: RARB_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | A naphthalene derivative that has specificity for RETINOIC ACID RECEPTORS. It is used as a DERMATOLOGIC AGENT for the treatment of ACNE. | Retinoid (Code: N0000175607) Retinoids (Code: N0000007700) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Dermatologic Agents (Code: D003879) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) dermatologic drug (Code: CHEBI:50177) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 1996-05-31 FDA | |
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| cinalukast | Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) Cysteinyl leukotriene receptor 1 (Organism: Cavia porcellus, class: GPCR, accessions: Q2NNR5, gene: CYSLTR1, swissprot: CLTR1_CAVPO) | None | anti-arrhythmia drug (Code: CHEBI:38070) anti-asthmatic drug (Code: CHEBI:49167) leukotriene antagonist (Code: CHEBI:49159) | |
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| calcipotriene | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | a topical dermatologic for the treatment of moderate plaque psoriasis | Vitamin D (Code: N0000006277) Vitamin D Analog (Code: N0000175849) Dermatologic Agents (Code: D003879) antipsoriatic (Code: CHEBI:50748) | 1993-12-29 FDA | 1S19 |
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| benzethonium | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) KiSS-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q969F8, gene: KISS1R, swissprot: KISSR_HUMAN) | Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) antiseptic drug (Code: CHEBI:48218) | None FDA | |
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| bretylium | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | 1986-03-06 FDA | |
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| talniflumate | an anti-inflammatory molecule for the treatment of cystic fibrosis, chronic obstructive pulmonary disease and asthma | |
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| doxercalciferol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | decrease of bone density caused by prednisolone was prevented by above cpd; decreases number of osteoclast areas in normal rats; RN given refers to (1alpha,3beta,5Z,7E,22E)-isomer | Ergocalciferols (Code: N0000006337) Vitamin D2 Analog (Code: N0000175907) bone density conservation agent (Code: CHEBI:50646) | 1999-06-09 FDA | 3DL9 |
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| nizofenone | Nizofenone is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke. | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | None PMDA | |
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| ziprasidone | D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) | a benzisothiazoylpiperazine derivative; has combined dopamine and serotonin receptor antagonist activity; structurally related to tiospirone | Atypical Antipsychotic (Code: N0000175430) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) psychotropic drug (Code: CHEBI:35471) histamine antagonist (Code: CHEBI:37956) muscarinic antagonist (Code: CHEBI:48876) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) antipsychotic agent (Code: CHEBI:35476) | 2001-02-05 FDA | |
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| thiamphenicol glycinate | None | |
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| etodroxizine | None | |
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| dichlorisone | None | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| noscapine | Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) | A naturally occurring opium alkaloid that is a centrally acting antitussive agent. | Antitussive Agents (Code: D000996) Central Nervous System Agents (Code: D002491) Respiratory System Agents (Code: D019141) antitussive (Code: CHEBI:51177) antineoplastic agent (Code: CHEBI:35610) | |
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| desoxycorticosterone pivalate | Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) | None | None FDA | |
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| podophyllotoxin | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tubulin (Organism: Sus scrofa, class: Structural, accessions: P02550|P02554, gene: TUBA1A, swissprot: TBA1A_PIG|TBB_PIG) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Tubulin alpha-1A chain (Organism: Sus scrofa, class: Structural, accessions: P02550, gene: TUBA1A, swissprot: TBA1A_PIG) Human papillomavirus regulatory protein E2 (Organism: Human papillomavirus type 16, class: Unclassified, accessions: P03120, gene: E2, swissprot: VE2_HPV16) Regulatory protein E2 (Organism: Human papillomavirus type 11, class: Unclassified, accessions: P04015, gene: E2, swissprot: VE2_HPV11) Regulatory protein E2 (Organism: Human papillomavirus type 1a, class: Unclassified, accessions: P03118, gene: E2, swissprot: VE2_HPV1A) Tubulin (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68363|P68366|P68371|Q13509|Q13748|Q13885|Q3ZCM7|Q6PEY2|Q71U36|Q9BQE3|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBA1A_HUMAN|TBA1B_HUMAN|TBA1C_HUMAN|TBA3C_HUMAN|TBA3E_HUMAN|TBA4A_HUMAN|TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) Tubulin (Organism: Bos taurus, class: Structural, accessions: Q6B856|Q862F3|Q862L2, gene: TUBB2B, swissprot: Q862F3_BOVIN|Q862L2_BOVIN|TBB2B_BOVIN) | A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. | Decreased Mitosis (Code: N0000008732) Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Dermatologic Agents (Code: D003879) Keratolytic Agents (Code: D007641) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) antineoplastic agent (Code: CHEBI:35610) keratolytic drug (Code: CHEBI:50176) | 1990-12-13 FDA | 1SA1 |
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| sancycline | None | |
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| sulbenicillin | Semisynthetic penicillin-type antibiotic. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| temocillin | beta-lactam antibiotic with unusual spectrum of antibacterial activity & exceptional stability to bacterial beta-lactamases; RN given refers to di-Na salt (2S-(2alpha,5alpha,6alpha))-isomer | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1984-01-01 YEAR INTRODUCED | |
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| mesulfen | used in therapy of scabies; structure | |
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| nafcillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Penicillin-binding protein (Organism: Staphylococcus aureus, class: Enzyme, accessions: P72355|Q53707|Q53725|Q53729|Q9XDB3, gene: PBP2|mecA|pbp4|pbpA|pbpF, swissprot: P72355_STAAU|Q53707_STAAU|Q53725_STAAU|Q53729_STAAU|Q9XDB3_STAAU) | A semi-synthetic antibiotic related to penicillin. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1965-10-11 FDA | 1T9W |
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| eplerenone | Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Aldosterone Antagonist (Code: N0000175557) Aldosterone Antagonists (Code: N0000011310) Diuretics (Code: D004232) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoid Receptor Antagonists (Code: D000451) Natriuretic Agents (Code: D045283) antihypertensive agent (Code: CHEBI:35674) | 2002-09-27 FDA | 5MWY |
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| diltiazem | Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Oryctolagus cuniculus, class: Ion channel, accessions: P15381, gene: CACNA1C, swissprot: CAC1C_RABIT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1S (Organism: Homo sapiens, class: Ion channel, accessions: Q13698, gene: CACNA1S, swissprot: CAC1S_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Voltage-gated L-type calcium channel (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002|P27732|Q02485, gene: Cacna1c|Cacna1d|Cacna1s, swissprot: CAC1C_RAT|CAC1D_RAT|CAC1S_RAT) Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Rattus norvegicus, class: Ion channel, accessions: P27732, gene: Cacna1d, swissprot: CAC1D_RAT) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Potassium voltage-gated channel subfamily C member 1 (Organism: Mus musculus, class: Unclassified, accessions: P15388, gene: Kcnc1, swissprot: KCNC1_MOUSE) Potassium voltage-gated channel subfamily A member 7 (Organism: Mus musculus, class: Unclassified, accessions: Q17ST2, gene: Kcna7, swissprot: KCNA7_MOUSE) Voltage-dependent L-type calcium channel subunit alpha-1F (Organism: Mus musculus, class: Unclassified, accessions: Q9JIS7, gene: Cacna1f, swissprot: CAC1F_MOUSE) | A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions. | Calcium Channel Antagonists (Code: N0000000069) Calcium Channel Blocker (Code: N0000175566) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) antihypertensive agent (Code: CHEBI:35674) | 1982-11-05 FDA | |
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| gestonorone caproate | A long-acting potent progestogen structurally related to PROGESTERONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1185) | |
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| cefpimizole | semisynthetic cephalosporin | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| sitosterol | Nuclear factor NF-kappa-B p105 subunit (Organism: Homo sapiens, class: Cytosolic other, accessions: P19838, gene: NFKB1, swissprot: NFKB1_HUMAN) DNA polymerase beta (Organism: Homo sapiens, class: Enzyme, accessions: P06746, gene: POLB, swissprot: DPOLB_HUMAN) Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) | used as tranquillizer; sedative; or anticonvulsant; structure | Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Indicators and Reagents (Code: D007202) Intercalating Agents (Code: D007364) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) anticholesteremic drug (Code: CHEBI:35821) | None FDA | |
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| salmeterol | Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) | A selective ADRENERGIC BETA-2 RECEPTOR agonist that functions as a BRONCHODILATOR when administered by inhalation. It is used to manage the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE. | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) bronchodilator agent (Code: CHEBI:35523) beta-adrenergic agonist (Code: CHEBI:35522) | 1994-02-04 FDA | |
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| bimatoprost | Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) | A cloprostenol-derived amide that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. | Prostaglandin Analog (Code: N0000175454) Prostaglandins (Code: N0000007706) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) antiglaucoma drug (Code: CHEBI:39456) | 2002-03-08 EMA 2001-03-16 FDA | 2F38 |
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| acemetacin | Lactoylglutathione lyase (Organism: Homo sapiens, class: Enzyme, accessions: Q04760, gene: GLO1, swissprot: LGUL_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-narcotic analgesic (Code: CHEBI:35481) prodrug (Code: CHEBI:50266) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | |
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| rupatadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Platelet-activating factor receptor (Organism: Homo sapiens, class: GPCR, accessions: P25105, gene: PTAFR, swissprot: PTAFR_HUMAN) | Rupatadine is a second-generation antihistamine, long-acting histamine antagonist with selective peripheral H1-receptor and platelet activating factor (PAF) antagonistic activities. Some of the metabolites (desloratadine and its hydroxylated metabolites) retain an antihistaminic activity and may partially contribute to the overall efficacy of the drug, maintaining activity for up to 24 hours. | 2017-09-27 PMDA | |
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| isoconazole | Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | None | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) antibacterial drug (Code: CHEBI:36047) | |
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| miconazole | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Type-2 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P50052, gene: AGTR2, swissprot: AGTR2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Malate dehydrogenase cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P40925, gene: MDH1, swissprot: MDHC_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Aromatase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22443, gene: Cyp19a1, swissprot: CP19A_RAT) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Homo sapiens, class: Enzyme, accessions: P05186, gene: ALPL, swissprot: PPBT_HUMAN) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | An imidazole antifungal agent that is used topically and by intravenous infusion. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 CYP2C9 Inhibitors (Code: D065688) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) antineoplastic agent (Code: CHEBI:35610) | 1974-01-08 FDA | 3OZU |
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| tenitramine | None | |
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| trovafloxacin | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Topoisomerase IV (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2|P20083, gene: parC|parE, swissprot: PARC_ECOLI|PARE_ECOLI) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) | a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity | Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) | 1997-12-18 FDA | 4KOE 4Z2E 4Z53 |
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| guaiacol phosphate | None | |
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| ramatroban | Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Prostaglandin D2 receptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q6XKD3, gene: Ptgdr2, swissprot: PD2R2_RAT) Prostaglandin D2 receptor 2 (Organism: Mus musculus, class: Unclassified, accessions: Q9Z2J6, gene: Ptgdr2, swissprot: PD2R2_MOUSE) | thromboxane A2 receptor antagonist; BAY u 3405 & 3406 are enantiomers of each other | Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) | |
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| pyrinoline | None | |
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| cefaloridine | A cephalosporin antibiotic. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | |
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| desonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Inflammatory Agents (Code: D000893) anti-inflammatory drug (Code: CHEBI:35472) | 1972-01-04 FDA | |
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| methylprednisolone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Anti-Inflammatory Agents (Code: D000893) anti-inflammatory drug (Code: CHEBI:35472) | 1959-05-27 FDA | |
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| ramipril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) | A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat. | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) prodrug (Code: CHEBI:50266) cardioprotective agent (Code: CHEBI:77307) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) | 1991-01-28 FDA | |
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| distigmine | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | None | Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) | 1967-09-05 PMDA | |
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| iopronic acid | None | |
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| alfentanil | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Full Opioid Agonists (Code: N0000175684) Opioid Agonist (Code: N0000175690) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) intravenous anaesthetic (Code: CHEBI:38877) central nervous system depressant (Code: CHEBI:35488) peripheral nervous system drug (Code: CHEBI:49110) | 1986-12-29 FDA | |
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| spironolactone | Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) | A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827) | Aldosterone Antagonist (Code: N0000175557) Aldosterone Antagonists (Code: N0000011310) Diuretics (Code: D004232) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Mineralocorticoid Receptor Antagonists (Code: D000451) Natriuretic Agents (Code: D045283) diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) | 1960-01-21 FDA | 2AB2 2OAX 3VHU |
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| colecalciferol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) Sterol 26-hydroxylase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q02318, gene: CYP27A1, swissprot: CP27A_HUMAN) Vitamin D 25-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: Q6VVX0, gene: CYP2R1, swissprot: CP2R1_HUMAN) 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: O15528, gene: CYP27B1, swissprot: CP27B_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. | Vitamin D (Code: N0000006277) Bone Density Conservation Agents (Code: D050071) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) | 2000-05-18 FDA | |
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| secalciferol | None | |
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| diiodotyrosine | A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE). | 1CTP 1L0S 2AXE 2C3V 2D8O 2D8P 2D8W 2D97 2D98 2NOO 2VLW 3GH8 4IKM 4PGC 4TTU 4TVC 4TVD 5N1C |
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| paricalcitol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | suppressed immunoglobulin production & thymic lymphocyte proliferation in vivo | Cholecalciferol (Code: N0000006996) Vitamin D3 Analog (Code: N0000175908) antiparathyroid drug (Code: CHEBI:50827) | 1998-04-17 FDA | |
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| calcitriol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) Vitamin D 25-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: Q6VVX0, gene: CYP2R1, swissprot: CP2R1_HUMAN) 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: O15528, gene: CYP27B1, swissprot: CP27B_HUMAN) Vitamin D3 receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q28037, gene: VDR, swissprot: VDR_BOVIN) Vitamin D3 receptor (Organism: Sus scrofa, class: Unclassified, accessions: A3RGC1, gene: VDR, swissprot: VDR_PIG) Vitamin D3 receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P13053, gene: Vdr, swissprot: VDR_RAT) Vitamin D3 receptor (Organism: Gallus gallus, class: Transcription factor, accessions: O42392, gene: VDR, swissprot: VDR_CHICK) Vitamin D-binding protein (Organism: Homo sapiens, class: Secreted, accessions: P02774, gene: GC, swissprot: VTDB_HUMAN) Vitamin D3 receptor A (Organism: Danio rerio, class: Nuclear hormone receptor, accessions: Q9PTN2, gene: vdra, swissprot: VDRA_DANRE) | The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption. | Cholecalciferol (Code: N0000006996) Vitamin D3 Analog (Code: N0000175908) Bone Density Conservation Agents (Code: D050071) Calcium Channel Agonists (Code: D002120) Cardiovascular Agents (Code: D002317) Growth Substances (Code: D006133) Membrane Transport Modulators (Code: D049990) Micronutrients (Code: D018977) Vasoconstrictor Agents (Code: D014662) Vitamins (Code: D014815) nutraceutical (Code: CHEBI:50733) antipsoriatic (Code: CHEBI:50748) immunomodulator (Code: CHEBI:50846) antineoplastic agent (Code: CHEBI:35610) bone density conservation agent (Code: CHEBI:50646) | 1978-08-17 FDA | 1DB1 1IE9 1RK3 2HC4 2ZBZ 2ZLC 3CV9 3M7R 3VT3 3VT7 4RUJ 5H1E |
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| temafloxacin | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) | |
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| bisoxatin acetate | None | |
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| ibacitabine | None | |
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| cilazapril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | |
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| nimodipine | Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1F (Organism: Homo sapiens, class: Ion channel, accessions: O60840, gene: CACNA1F, swissprot: CAC1F_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Voltage-dependent L-type calcium channel subunit alpha-1S (Organism: Homo sapiens, class: Ion channel, accessions: Q13698, gene: CACNA1S, swissprot: CAC1S_HUMAN) | A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure. | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) cardiovascular drug (Code: CHEBI:35554) | 1988-12-28 FDA | 5KMF |
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| simvastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843), class: Unclassified, accessions: Q10283, gene: hmg1, swissprot: HMDH_SCHPO) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) | A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL. | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) prodrug (Code: CHEBI:50266) | 1991-12-23 FDA | |
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| maxacalcitol | Vitamin D3 receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P13053, gene: Vdr, swissprot: VDR_RAT) | None | Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Dermatologic Agents (Code: D003879) Protective Agents (Code: D020011) | 3B0T |
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| lofepramine | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) | A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE. | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) antidepressant (Code: CHEBI:35469) | 1977-01-01 YEAR INTRODUCED | |
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| thyropropic acid | Proliferating cell nuclear antigen (Organism: Homo sapiens, class: Unclassified, accessions: P12004, gene: PCNA, swissprot: PCNA_HUMAN) Thyroid hormone receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827, gene: THRA, swissprot: THA_HUMAN) Thyroid hormone receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10828, gene: THRB, swissprot: THB_HUMAN) | None | |
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| bromperidol | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) | bromine-substituted for chlorine in haloperidol; RN given refers to unlabeled parent cpd; structure | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1973-01-01 YEAR INTRODUCED | |
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| amtolmetin guacil | None | |
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| hexoprenaline | Stimulant of adrenergic beta 2 receptors. It is used as a bronchodilator, antiasthmatic agent, and tocolytic agent. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Respiratory System Agents (Code: D019141) Tocolytic Agents (Code: D015149) | |
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| levocabastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Neurotensin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: O95665, gene: NTSR2, swissprot: NTR2_HUMAN) Neurotensin receptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63384, gene: Ntsr2, swissprot: NTR2_RAT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | 1993-11-10 FDA | |
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| pipebuzone | None | |
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| etofylline clofibrate | whole issue; structure given in first source | Antimetabolites (Code: D000963) Antioxidants (Code: D000975) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Protective Agents (Code: D020011) Radiation-Sensitizing Agents (Code: D011838) | |
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| bendroflumethiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) | A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Increased Diuresis (Code: N0000175359) Thiazide Diuretic (Code: N0000175419) Thiazides (Code: N0000166469) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) | 1959-12-07 FDA | |
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| pipecuronium | Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) | A piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures. | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | 1990-06-26 FDA | |
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| topotecan | DNA topoisomerase I, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q969P6, gene: TOP1MT, swissprot: TOP1M_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) Hypoxia-inducible factor 1-alpha (Organism: Homo sapiens, class: Transcription factor, accessions: Q16665, gene: HIF1A, swissprot: HIF1A_HUMAN) DNA topoisomerase I (Organism: Mus musculus, class: Unclassified, accessions: Q04750, gene: Top1, swissprot: TOP1_MOUSE) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) ORF 73 (Organism: Human herpesvirus 8, class: Unclassified, accessions: O40947, gene: None, swissprot: O40947_HHV8) UDP-galactopyranose mutase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WIQ1, gene: glf, swissprot: GLF_MYCTU) | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I. | Topoisomerase Inhibitor (Code: N0000175609) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase I Inhibitors (Code: D059004) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) | 1996-05-28 FDA | 1K4T 1RR8 1RRJ |
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| pitavastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) | Pitavastatin competitively inhibits HMG-CoA reductase, which is a rate-determining enzyme involved with biosynthesis of cholesterol, in a manner of competition with the substrate so that it inhibits cholesterol synthesis in the liver. As a result, the expression of LDL-receptors followed by the uptake of LDL from blood to liver is accelerated and then the plasma TC decreases. Further, the sustained inhibition of cholesterol synthesis in the liver decreases levels of very low density lipoproteins. | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 2009-08-03 FDA | |
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| mopidamol | A phosphodiesterase inhibitor which inhibits platelet aggregation. Formerly used as an antineoplastic. | Antineoplastic Agents (Code: D000970) | |
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| pentacynium chloride | None | |
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| mosapride | 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Mosapride is a 5-HT4 receptor agonist which increases the release of acetylcholine and stimulates GI motility. | Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) | 1998-01-01 YEAR INTRODUCED | |
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| conivaptan | Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) | None | Antidiuretic Hormone Antagonists (Code: N0000009945) Vasopressin Antagonist (Code: N0000178376) Antidiuretic Hormone Receptor Antagonists (Code: D065092) Natriuretic Agents (Code: D045283) Vasopressin Receptor Antagonists (Code: N0000020044) Cytochrome P450 3A Inhibitors (Code: N0000190114) vasopressin receptor antagonist (Code: CHEBI:59680) | 2005-12-29 FDA | |
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| nandrolone cyclotate | None | |
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| losartan | Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Type-1 angiotensin II receptor (Organism: Oryctolagus cuniculus, class: GPCR, accessions: P34976, gene: AGTR1, swissprot: AGTR1_RABIT) Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089|P35351, gene: Agtr1|Agtr1b|Agtr2, swissprot: AGTR2_RAT|AGTRA_RAT|AGTRB_RAT) Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) Type-2 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P50052, gene: AGTR2, swissprot: AGTR2_HUMAN) Type-2 angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P35351, gene: Agtr2, swissprot: AGTR2_RAT) Type-1A angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095, gene: Agtr1, swissprot: AGTRA_RAT) Type-1 angiotensin II receptor (Organism: Bos taurus, class: GPCR, accessions: P25104, gene: AGTR1, swissprot: AGTR1_BOVIN) Angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556|P50052, gene: AGTR1|AGTR2, swissprot: AGTR1_HUMAN|AGTR2_HUMAN) Angiotensin II receptor (AT-1) type-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089, gene: Agtr1|Agtr1b, swissprot: AGTRA_RAT|AGTRB_RAT) Type-1 angiotensin II receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q9WV26, gene: AGTR1, swissprot: AGTR1_CAVPO) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II. | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) anti-arrhythmia drug (Code: CHEBI:38070) angiotensin receptor antagonist (Code: CHEBI:61016) endothelin receptor antagonist (Code: CHEBI:51451) | 1995-04-14 FDA | 5X23 5X24 5XXI |
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| cefapirin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1974-03-12 FDA | |
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| bromoform | None | Carcinogens (Code: D002273) Noxae (Code: D009676) Teratogens (Code: D013723) | |
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| gallamine | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Sus scrofa, class: GPCR, accessions: P06199, gene: CHRM2, swissprot: ACM2_PIG) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholine receptor subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P02708, gene: CHRNA1, swissprot: ACHA_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) | A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198) | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | None FDA | 1N5M |
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| carfenazine | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | None | dopaminergic antagonist (Code: CHEBI:48561) antiemetic (Code: CHEBI:50919) phenothiazine antipsychotic drug (Code: CHEBI:37930) | None FDA | |
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| omoconazole | an imidazole antifungal which inhibits the cytochrome P450-dependent enzymes, resulting in impairment of ergosterol synthesis in fungal cell membranes | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| benzbromarone | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Aldo-keto reductase family 1 member C1 (Organism: Homo sapiens, class: Enzyme, accessions: Q04828, gene: AKR1C1, swissprot: AK1C1_HUMAN) Solute carrier family 22 member 12 (Organism: Homo sapiens, class: Transporter, accessions: Q96S37, gene: SLC22A12, swissprot: S22AC_HUMAN) Envelope glycoprotein gp160 (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q6QLK5, gene: env, swissprot: Q6QLK5_9HIV1) M1-family alanyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8IEK1, gene: None, swissprot: Q8IEK1_PLAF7) | Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout. | Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) uricosuric drug (Code: CHEBI:35841) | |
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| cefuroxime | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) drug allergen (Code: CHEBI:88188) | 1983-10-19 FDA | 4KOV |
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| epitizide | None | |
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| benazepril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P47820, gene: Ace, swissprot: ACE_RAT) | prodrug of benazeprilat inhibit angiotensin-converting enzyme (ACE) and results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Decreased Blood Pressure (Code: N0000178477) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) prodrug (Code: CHEBI:50266) | 1991-06-25 FDA | |
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| eprosartan | Angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089|P35351, gene: Agtr1|Agtr1b|Agtr2, swissprot: AGTR2_RAT|AGTRA_RAT|AGTRB_RAT) Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) Type-2 angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P35351, gene: Agtr2, swissprot: AGTR2_RAT) Angiotensin II receptor (AT-1) type-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089, gene: Agtr1|Agtr1b, swissprot: AGTRA_RAT|AGTRB_RAT) | angiotensin II receptor antagonist; structure given in first source | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 2 Receptor Blockers (Code: D057912) Angiotensin Receptor Antagonists (Code: D057911) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) angiotensin receptor antagonist (Code: CHEBI:61016) antihypertensive agent (Code: CHEBI:35674) | 1997-12-22 FDA | |
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| pravastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) Solute carrier family 22 member 6 (Organism: Rattus norvegicus, class: Transporter, accessions: O35956, gene: Slc22a6, swissprot: S22A6_RAT) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) | An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES). | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 1991-10-31 FDA | |
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| alvimopan | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) | mu opioid receptor antagonist; intended to treat constipation in patients taking opiates for pain | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) Gastrointestinal Agents (Code: D005765) | 2008-05-20 FDA | |
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| oleandomycin | Antibiotic macrolide produced by Streptomyces antibioticus. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| difenoxin | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | an orally administered antidiarrheal agent which is chemically related to the narcotic meperidine | Antidiarrheal (Code: N0000178374) antidiarrhoeal drug (Code: CHEBI:55323) | 1978-07-14 FDA | |
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| unoprostone isopropyl | a safe and effective ocular hypotensive drug | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) prodrug (Code: CHEBI:50266) antiglaucoma drug (Code: CHEBI:39456) | 2000-08-03 FDA | |
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| pifarnine | non-anticholinergic gastric antisecretory agent | |
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| clindamycin | 50S ribosomal protein L10 (Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809), class: Ribosomal protein, accessions: P15825, gene: rpl10, swissprot: RL10_HALMA) | An antibacterial agent that is a semisynthetic analog of LINCOMYCIN. | Decreased Sebaceous Gland Activity (Code: N0000009982) Lincosamide Antibacterial (Code: N0000175443) Lincosamides (Code: N0000175442) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1970-02-22 FDA | 1JZX 1YJN 3JZ0 4V7V |
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| domperidone | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) antiemetic (Code: CHEBI:50919) dopaminergic antagonist (Code: CHEBI:48561) | 1982-01-01 YEAR INTRODUCED | |
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| sozoiodolic acid | radioopaque medium; wound antiseptic; Hg deriv formerly used in syphilis treatment; RN given refers to parent cpd; structure | |
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| garenoxacin | a des-fluoro(6) quinolone with antibacterial activity | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antibacterial drug (Code: CHEBI:36047) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 2007-05-30 PMDA | |
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| iloperidone | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) 5-hydroxytryptamine receptor 2A (Organism: Bos taurus, class: GPCR, accessions: Q75Z89, gene: HTR2A, swissprot: 5HT2A_BOVIN) 5-hydroxytryptamine receptor 1A (Organism: Mus musculus, class: GPCR, accessions: Q64264, gene: Htr1a, swissprot: 5HT1A_MOUSE) D(1A) dopamine receptor (Organism: Mus musculus, class: GPCR, accessions: Q61616, gene: Drd1, swissprot: DRD1_MOUSE) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Gastrin/cholecystokinin type B receptor (Organism: Homo sapiens, class: GPCR, accessions: P32239, gene: CCKBR, swissprot: GASR_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) | an atypical, negative symptom antipsychotic agent | Atypical Antipsychotic (Code: N0000175430) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) serotonergic antagonist (Code: CHEBI:48279) dopaminergic antagonist (Code: CHEBI:48561) second generation antipsychotic (Code: CHEBI:65191) | 2009-05-06 FDA | |
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| etofamide | None | Amebicides (Code: D000563) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | |
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| fenbenicillin | None | |
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| cetotiamine | None | |
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| darifenacin | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | a competitive muscarinic receptor antagonist with greater affinity for the M3 receptor than for the other known muscarinic receptors, M3 receptors are involved in contraction of human bladder and gastrointestinal smooth muscle, saliva production, and iris sphincter function | Cholinergic Muscarinic Antagonist (Code: N0000175700) Cholinergic Muscarinic Antagonists (Code: N0000000125) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) muscarinic antagonist (Code: CHEBI:48876) antispasmodic drug (Code: CHEBI:53784) | 2004-10-22 EMA 2004-12-22 FDA | |
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| oxatomide | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) | orally active H1-histamine receptor antagonist used to treat chronic urticaria and allergic rhinitis | Anti-Allergic Agents (Code: D018926) Anti-Asthmatic Agents (Code: D018927) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Respiratory System Agents (Code: D019141) | 1981-01-01 YEAR INTRODUCED | |
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| perospirone | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 2000-12-22 PMDA | |
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| pemetrexed | Folate receptor alpha (Organism: Homo sapiens, class: Membrane receptor, accessions: P15328, gene: FOLR1, swissprot: FOLR1_HUMAN) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Folylpolyglutamate synthase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q05932, gene: FPGS, swissprot: FOLC_HUMAN) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Thymidylate synthase (Organism: Escherichia coli, class: Enzyme, accessions: C3SWJ7, gene: thyA, swissprot: C3SWJ7_ECOLX) Thymidylate synthase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00469, gene: thyA, swissprot: TYSY_LACCA) Serine hydroxymethyltransferase, cytosolic (Organism: Homo sapiens, class: Enzyme, accessions: P34896, gene: SHMT1, swissprot: GLYC_HUMAN) Thymidylate synthase (Organism: Rattus norvegicus, class: Enzyme, accessions: P45352, gene: Tyms, swissprot: TYSY_RAT) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Thymidylate synthase (Organism: Mus musculus, class: Enzyme, accessions: P07607, gene: Tyms, swissprot: TYSY_MOUSE) Proton-coupled folate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q96NT5, gene: SLC46A1, swissprot: PCFT_HUMAN) Dihydrofolate reductase (Organism: Mus musculus, class: Enzyme, accessions: P00375, gene: Dhfr, swissprot: DYR_MOUSE) Trifunctional purine biosynthetic protein adenosine-3 (Organism: Homo sapiens, class: Enzyme, accessions: P22102, gene: GART, swissprot: PUR2_HUMAN) Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) (Organism: Escherichia coli, class: Enzyme, accessions: E2QDN0, gene: None, swissprot: E2QDN0_ECOLX) Folate transporter 1 (Organism: Homo sapiens, class: Unclassified, accessions: P41440, gene: SLC19A1, swissprot: S19A1_HUMAN) Folate receptor beta (Organism: Homo sapiens, class: Membrane receptor, accessions: P14207, gene: FOLR2, swissprot: FOLR2_HUMAN) Trifunctional purine biosynthetic protein adenosine-3 (Organism: Mus musculus, class: Unclassified, accessions: Q64737, gene: Gart, swissprot: PUR2_MOUSE) | A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE. | Folate Analog Metabolic Inhibitor (Code: N0000175584) Folic Acid Metabolism Inhibitors (Code: N0000000111) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) Nucleic Acid Synthesis Inhibitors (Code: D019384) antineoplastic agent (Code: CHEBI:35610) | 2004-02-04 FDA | 1JU6 1JUJ 2X9G 3K2H 4FQS 4KN2 4LVY |
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| salazosulfadimidine | None | |
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| buclizine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) antiemetic (Code: CHEBI:50919) cholinergic antagonist (Code: CHEBI:48873) histamine antagonist (Code: CHEBI:37956) local anaesthetic (Code: CHEBI:36333) central nervous system depressant (Code: CHEBI:35488) | None FDA | |
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| cefoxitin | Beta-lactamase (Organism: Bacillus licheniformis, class: Enzyme, accessions: P00808, gene: penP, swissprot: BLAC_BACLI) Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) Beta-lactamase (Organism: Acinetobacter baumannii, class: Enzyme, accessions: B2ZTR6, gene: None, swissprot: B2ZTR6_ACIBA) Beta-lactamase (Organism: Acinetobacter baumannii, class: Enzyme, accessions: D6NSM8, gene: ampC, swissprot: D6NSM8_ACIBA) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semisynthetic cephamycin antibiotic resistant to beta-lactamase. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1978-10-18 FDA | 1I2W 1YMX 3MZE 4KOW |
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| moracizine | Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | An antiarrhythmia agent used primarily for ventricular rhythm disturbances. | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) anti-arrhythmia drug (Code: CHEBI:38070) | 1990-06-19 FDA | |
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| ranolazine | Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) | An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS. | Anti-anginal (Code: N0000175427) Cytochrome P450 3A Inhibitors (Code: N0000190114) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) anti-arrhythmia drug (Code: CHEBI:38070) | 2006-01-27 FDA | |
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| mozavaptan | Vasopressin V1b receptor (Organism: Homo sapiens, class: GPCR, accessions: P47901, gene: AVPR1B, swissprot: V1BR_HUMAN) Vasopressin V2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q00788, gene: Avpr2, swissprot: V2R_RAT) Oxytocin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30559, gene: OXTR, swissprot: OXYR_HUMAN) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Vasopressin V1a receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560, gene: Avpr1a, swissprot: V1AR_RAT) Vasopressin V1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560|P48974, gene: Avpr1a|Avpr1b, swissprot: V1AR_RAT|V1BR_RAT) | Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors. Mozavaptan can inhibit the antidiuretic action of AVP promoting aquaresis. | Antidiuretic Hormone Receptor Antagonists (Code: D065092) Natriuretic Agents (Code: D045283) | 2006-07-26 PMDA | |
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| dixyrazine | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Antiemetics (Code: D000932) Antipsychotic Agents (Code: D014150) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) | |
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| fosfestrol | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372|Q92731, gene: ESR1|ESR2, swissprot: ESR1_HUMAN|ESR2_HUMAN) | Rx of prostatic carcinoma; RN given refers to parent cpd with unspecified isomeric designation; structure | Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) | None FDA | |
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| mebeverine | None | Anticonvulsants (Code: D000927) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| irbesartan | Sodium/bile acid cotransporter (Organism: Homo sapiens, class: Transporter, accessions: Q14973, gene: SLC10A1, swissprot: NTCP_HUMAN) Angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089|P35351, gene: Agtr1|Agtr1b|Agtr2, swissprot: AGTR2_RAT|AGTRA_RAT|AGTRB_RAT) Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) Angiotensin II receptor (AT-1) type-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089, gene: Agtr1|Agtr1b, swissprot: AGTRA_RAT|AGTRB_RAT) | a nonpeptide At(1) subtype angiotensin II receptor antagonist; structure given in first source | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) angiotensin receptor antagonist (Code: CHEBI:61016) | 1997-09-30 FDA | |
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| nandrolone decanoate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | None | Anabolic Agents (Code: D045930) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1962-10-05 FDA | |
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| oxiconazole | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | None | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) antiinfective agent (Code: CHEBI:35441) | 1988-12-30 FDA | |
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| altropane | a SPECT imaging agent for viewing dopamine transporter sites | |
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| sarpogrelate | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) | None | Cardiovascular Agents (Code: D002317) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Neurotransmitter Agents (Code: D018377) Platelet Aggregation Inhibitors (Code: D010975) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) | |
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| zofenopril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P47820, gene: Ace, swissprot: ACE_RAT) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) anticonvulsant (Code: CHEBI:35623) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) cardioprotective agent (Code: CHEBI:77307) prodrug (Code: CHEBI:50266) vasodilator agent (Code: CHEBI:35620) | |
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| piritramide | A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage. | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| mifepristone | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Progesterone receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: Q63449, gene: Pgr, swissprot: PRGR_RAT) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) P-glycoprotein 3 (Organism: Mus musculus, class: Unclassified, accessions: P21447, gene: Abcb1a, swissprot: MDR1A_MOUSE) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) | A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME. | Progestational Hormone Receptor Antagonists (Code: N0000000115) Progestin Antagonist (Code: N0000175841) Abortifacient Agents (Code: D000019) Abortifacient Agents, Steroidal (Code: D000021) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Contraceptives, Postcoital (Code: D003281) Contraceptives, Postcoital, Synthetic (Code: D003283) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Luteolytic Agents (Code: D008186) Menstruation-Inducing Agents (Code: D008600) Reproductive Control Agents (Code: D012102) hormone antagonist (Code: CHEBI:49020) contraceptive drug (Code: CHEBI:49323) synthetic oral contraceptive (Code: CHEBI:49326) abortifacient (Code: CHEBI:50691) | 2000-09-28 FDA | 1NHZ 2W8Y 3H52 3QT0 4LTW 5UC1 5UC3 |
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| bicalutamide | Progesterone receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: Q63449, gene: Pgr, swissprot: PRGR_RAT) Progesterone receptor (Organism: Oryctolagus cuniculus, class: Transcription factor, accessions: P06186, gene: PGR, swissprot: PRGR_RABIT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Androgen receptor (Organism: Mus musculus, class: Transcription factor, accessions: P19091, gene: Ar, swissprot: ANDR_MOUSE) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) | Bicalutamide is a non-steroidal androgen receptor inhibitor. It competitively inhibits the action of androgens by binding to cytosol androgen receptors in the target tissue. Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen. | Androgen Receptor Antagonists (Code: N0000000243) Androgen Receptor Inhibitor (Code: N0000175560) Androgen Antagonists (Code: D000726) Antineoplastic Agents (Code: D000970) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) androgen antagonist (Code: CHEBI:35497) antineoplastic agent (Code: CHEBI:35610) | 1995-10-04 FDA | 1Z95 4FIA 4LA0 4OJB 4OK1 4OKB 4OKT 4OKW 4OKX 4OLM |
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| budesonide | Interferon gamma (Organism: Homo sapiens, class: Cytokine, accessions: P01579, gene: IFNG, swissprot: IFNG_HUMAN) Interleukin-5 (Organism: Homo sapiens, class: Cytokine, accessions: P05113, gene: IL5, swissprot: IL5_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Interleukin-5 (Organism: Mus musculus, class: Unclassified, accessions: P04401, gene: Il5, swissprot: IL5_MOUSE) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) | A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) bronchodilator agent (Code: CHEBI:35523) anti-inflammatory drug (Code: CHEBI:35472) | 1994-02-14 FDA | 5NFP |
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| benzthiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) | None | diuretic (Code: CHEBI:35498) antihypertensive agent (Code: CHEBI:35674) | 1960-10-14 FDA | |
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| trandolapril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1996-04-26 FDA | |
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| carbifene | None | |
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| lafutidine | histamine H(2)-receptor antagonist used as an antiulcer drug | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Neurotransmitter Agents (Code: D018377) | |
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| fluprednidene acetate | has anti-inflammatory & anti-allergic properties; minor descriptor (75-83); on-line & Index Medicus search PREGNADIENETRIOLS (75-83); RN given refers to (11beta)-isomer; structure | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| mizolastine | Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | a long-acting H1-antihistamine indicated for the symptomatic relief of seasonal allergic rhinoconjunctivitis (hay fever), perennial allergic rhinoconjunctivitis and urticaria | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | 2003-03-07 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| hydrocortisone butyrate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | dermatologic drug (Code: CHEBI:50177) | 1982-03-31 FDA | |
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| latanoprost | Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) | None | Prostaglandin Analog (Code: N0000175454) Prostaglandins (Code: N0000007706) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) prodrug (Code: CHEBI:50266) antiglaucoma drug (Code: CHEBI:39456) | 1996-06-05 FDA | |
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| clometocillin | None | antibacterial drug (Code: CHEBI:36047) | |
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| brovincamine | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| mycophenolate mofetil | Inosine-5'-monophosphate dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P12268, gene: IMPDH2, swissprot: IMDH2_HUMAN) Inosine-5'-monophosphate dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P20839, gene: IMPDH1, swissprot: IMDH1_HUMAN) | None | 1995-05-03 FDA | |
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| belotecan | DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) | None | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase I Inhibitors (Code: D059004) Topoisomerase Inhibitors (Code: D059003) | 2003-12-10 Korean Food and Drug Administration (KFDA) | |
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| lubeluzole | Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) | a benzothiazole compound; used for the treatment of acute ischemic stroke; R-91154 is the inactive isomer | Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | |
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| sivelestat | Myeloblastin (Organism: Homo sapiens, class: Unclassified, accessions: P24158, gene: PRTN3, swissprot: PRTN3_HUMAN) Neutrophil elastase (Organism: Homo sapiens, class: Enzyme, accessions: P08246, gene: ELANE, swissprot: ELNE_HUMAN) Neutrophil elastase (Organism: Mus musculus, class: Unclassified, accessions: Q3UP87, gene: Elane, swissprot: ELNE_MOUSE) | inhibitor of neutrophil elastase; structure given in first source | Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) | None PMDA | |
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| fluperolone | None | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| triamcinolone acetonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) | An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) | 1960-01-04 FDA | 5UFS |
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| rutoside | Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Serum albumin (Organism: Bos taurus, class: Secreted, accessions: P02769, gene: ALB, swissprot: ALBU_BOVIN) Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) Sialidase (Organism: Clostridium perfringens, class: Enzyme, accessions: P10481, gene: nanH, swissprot: NANH_CLOPF) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Neuromedin-U receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9GZQ4, gene: NMUR2, swissprot: NMUR2_HUMAN) Neuraminidase (Organism: Influenza A virus (strain A/USSR/90/1977 H1N1), class: Unclassified, accessions: P03469, gene: NA, swissprot: NRAM_I77AB) | A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility. | 1RY8 |
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| flunisolide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | corticosteroid prescribed as treatment for allergic rhinitis | Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Respiratory System Agents (Code: D019141) immunosuppressive agent (Code: CHEBI:35705) anti-inflammatory drug (Code: CHEBI:35472) anti-asthmatic drug (Code: CHEBI:49167) | 1981-09-24 FDA | |
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| dexamethasone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Anti-Inflammatory Agents (Code: D000893) | 1973-09-06 FDA | |
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| betamethasone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1965-03-03 FDA | |
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| niperotidine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) | None | |
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| pirarubicin | None | Antineoplastic Agents (Code: D000970) | |
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| glisolamide | None | |
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| flupentixol | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) | A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595) | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1964-01-01 YEAR INTRODUCED | |
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| chlorbenzoxamine | None | |
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| etravirine | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 2 (Organism: Homo sapiens, class: Transporter, accessions: O15438, gene: ABCC3, swissprot: MRP3_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Reverse transcriptase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9WKE8, gene: reverse transcriptas, swissprot: Q9WKE8_9HIV1) | HIV-1 reverse transriptase inhibitor; an anti-HIV agent | Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175463) Non-Nucleoside Analog (Code: N0000175460) Non-Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009948) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 2008-08-28 EMA 2008-01-18 FDA | 1SV5 3M8P 3MEC 3MED |
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| cloxotestosterone | None | |
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| sertaconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) | None | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) antibacterial drug (Code: CHEBI:36047) antipruritic drug (Code: CHEBI:59683) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 2003-12-10 FDA | |
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| aztreonam | Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) Peptidoglycan synthase FtsI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD68, gene: ftsI, swissprot: FTSI_ECOLI) Penicillin-binding protein 1A (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: Q07806, gene: mrcA, swissprot: PBPA_PSEAE) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: A4ZYU9, gene: blaACC-4, swissprot: A4ZYU9_ECOLX) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) AmpC (Organism: Escherichia coli, class: Unclassified, accessions: Q83TT7, gene: ampC, swissprot: Q83TT7_ECOLX) Beta-lactamase (Organism: Acinetobacter baumannii, class: Enzyme, accessions: B2ZTR6, gene: None, swissprot: B2ZTR6_ACIBA) Beta-lactamase (Organism: Acinetobacter baumannii, class: Enzyme, accessions: D6NSM8, gene: ampC, swissprot: D6NSM8_ACIBA) Efflux transporter; SugE (Organism: Salmonella newport, class: Unclassified, accessions: Q3S5C3, gene: sugE, swissprot: Q3S5C3_SALNE) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q48435, gene: bla LAT-2, swissprot: Q48435_KLEPN) | A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms. | Monobactam Antibacterial (Code: N0000175493) Monobactams (Code: N0000011311) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) drug allergen (Code: CHEBI:88188) antibacterial drug (Code: CHEBI:36047) | 1986-12-31 FDA | |
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| exatecan | DX-8951a is hydrochloride & DX-895If is methanesulfonate; exatecan mesylate is a synonym for DX-8951f; structure given in first and second source | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase I Inhibitors (Code: D059004) Topoisomerase Inhibitors (Code: D059003) | |
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| trimazosin | None | Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | |
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| valsartan | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) Type-1A angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095, gene: Agtr1, swissprot: AGTRA_RAT) Angiotensin II receptor (AT-1) type-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089, gene: Agtr1|Agtr1b, swissprot: AGTRA_RAT|AGTRB_RAT) | A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION. | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) angiotensin receptor antagonist (Code: CHEBI:61016) | 1996-12-23 FDA | |
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| decamethonium | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) Muscle-type nicotinic acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q04844|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNE|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHE_HUMAN|ACHG_HUMAN) | None | nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) muscle relaxant (Code: CHEBI:51371) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Depolarizing Agents (Code: D009467) Peripheral Nervous System Agents (Code: D018373) | 1975-05-21 FDA | 1ACL 1MAA 2XUD 3MES 5E2I 5E4J 6EP4 |
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| cloxacillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Beta-lactamase TEM (Organism: Salmonella typhi, class: Enzyme, accessions: P62594, gene: bla, swissprot: BLAT_SALTI) Beta-lactamase TEM (Organism: Escherichia coli, class: Enzyme, accessions: P62593, gene: bla; blaT-3; blaT-4;, swissprot: BLAT_ECOLX) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: A4ZYU9, gene: blaACC-4, swissprot: A4ZYU9_ECOLX) Efflux transporter; SugE (Organism: Salmonella newport, class: Unclassified, accessions: Q3S5C3, gene: sugE, swissprot: Q3S5C3_SALNE) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q48435, gene: bla LAT-2, swissprot: Q48435_KLEPN) Penicillin-binding protein (Organism: Staphylococcus aureus, class: Enzyme, accessions: P72355|Q53707|Q53725|Q53729|Q9XDB3, gene: PBP2|mecA|pbp4|pbpA|pbpF, swissprot: P72355_STAAU|Q53707_STAAU|Q53725_STAAU|Q53729_STAAU|Q9XDB3_STAAU) | A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1974-09-17 FDA | |
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| fluphenazine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Pleiotropic ABC efflux transporter of multiple drugs (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Transporter, accessions: P33302, gene: PDR5, swissprot: PDR5_YEAST) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) | A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE. | Phenothiazine (Code: N0000175746) Phenothiazines (Code: N0000007544) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) phenothiazine antipsychotic drug (Code: CHEBI:37930) dopaminergic antagonist (Code: CHEBI:48561) | 1959-09-09 FDA | |
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| fludroxycortide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733) | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1963-03-19 FDA | |
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| docusate sodium | All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt. | Surface-Active Agents (Code: D013501) | None FDA | |
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| bialamicol | None | |
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| tianeptine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | None | Antidepressive Agents (Code: D000928) Antidepressive Agents, Tricyclic (Code: D000929) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) | |
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| tigemonam | None | |
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| pazopanib | Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Phosphatidylinositol 4-kinase beta (Organism: Homo sapiens, class: Kinase, accessions: Q9UBF8, gene: PI4KB, swissprot: PI4KB_HUMAN) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) MAP/microtubule affinity-regulating kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27448, gene: MARK3, swissprot: MARK3_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) Cyclin-dependent kinase 11B (Organism: Homo sapiens, class: Kinase, accessions: P21127, gene: CDK11B, swissprot: CD11B_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Mitogen-activated protein kinase kinase kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: Q02779, gene: MAP3K10, swissprot: M3K10_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Organism: Homo sapiens, class: Kinase, accessions: Q8TBX8, gene: PIP4K2C, swissprot: PI42C_HUMAN) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Protein-tyrosine kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q13882, gene: PTK6, swissprot: PTK6_HUMAN) Calcium/calmodulin-dependent protein kinase type 1G (Organism: Homo sapiens, class: Kinase, accessions: Q96NX5, gene: CAMK1G, swissprot: KCC1G_HUMAN) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) Serine/threonine-protein kinase Nek2 (Organism: Homo sapiens, class: Kinase, accessions: P51955, gene: NEK2, swissprot: NEK2_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) LIM domain kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53667, gene: LIMK1, swissprot: LIMK1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) Serine/threonine-protein kinase Nek5 (Organism: Homo sapiens, class: Kinase, accessions: Q6P3R8, gene: NEK5, swissprot: NEK5_HUMAN) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Activin receptor type-2B (Organism: Homo sapiens, class: Kinase, accessions: Q13705, gene: ACVR2B, swissprot: AVR2B_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Organism: Homo sapiens, class: Kinase, accessions: O60331, gene: PIP5K1C, swissprot: PI51C_HUMAN) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Tyrosine-protein kinase Srms (Organism: Homo sapiens, class: Kinase, accessions: Q9H3Y6, gene: SRMS, swissprot: SRMS_HUMAN) Mitogen-activated protein kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13233, gene: MAP3K1, swissprot: M3K1_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) TGF-beta receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: P37173, gene: TGFBR2, swissprot: TGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) Dual specificity mitogen-activated protein kinase kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: P52564, gene: MAP2K6, swissprot: MP2K6_HUMAN) LIM domain kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P53671, gene: LIMK2, swissprot: LIMK2_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) Cyclin-dependent kinase 11A (Organism: Homo sapiens, class: Kinase, accessions: Q9UQ88, gene: CDK11A, swissprot: CD11A_HUMAN) Serine/threonine-protein kinase RIO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BVS4, gene: RIOK2, swissprot: RIOK2_HUMAN) Serine/threonine-protein kinase NLK (Organism: Homo sapiens, class: Kinase, accessions: Q9UBE8, gene: NLK, swissprot: NLK_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) | Pazopanib is a multi-tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR)-alpha and -beta, fibroblast growth factor receptor (FGFR)-1 and -3, cytokine receptor (Kit), interleukin-2 receptor-inducible T-cell kinase (Itk), leukocyte-specific protein tyrosine kinase (Lck), and transmembrane glycoprotein receptor tyrosine kinase (c-Fms). In vitro, pazopanib inhibited ligand-induced autophosphorylation of VEGFR-2, Kit, and PDGFR-beta receptors. In vivo, pazopanib inhibited VEGF-induced VEGFR-2 phosphorylation in mouse lungs, angiogenesis in a mouse model, and the growth of some human tumor xenografts in mice. | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) antineoplastic agent (Code: CHEBI:35610) angiogenesis modulating agent (Code: CHEBI:50926) | 2010-06-14 EMA 2009-10-19 FDA | |
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| triparanol | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) | Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts. | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| suxibuzone | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) antirheumatic drug (Code: CHEBI:35842) non-narcotic analgesic (Code: CHEBI:35481) peripheral nervous system drug (Code: CHEBI:49110) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) prodrug (Code: CHEBI:50266) | |
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| quinapril | Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) | 1991-11-19 FDA | |
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| flusalan | Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) | None | |
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| pivmecillinam | Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) prodrug (Code: CHEBI:50266) | |
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| polythiazide | Solute carrier family 12 member 3 (Organism: Homo sapiens, class: Transporter, accessions: P55017, gene: SLC12A3, swissprot: S12A3_HUMAN) | A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Increased Diuresis (Code: N0000175359) Thiazide Diuretic (Code: N0000175419) Thiazides (Code: N0000166469) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) Sodium Chloride Symporter Inhibitors (Code: D049993) | 1961-09-26 FDA | |
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| estramustine | A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. | Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Estradiol (Code: N0000007246) Nitrogen Mustard Compounds (Code: N0000007659) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Antineoplastic Agents, Hormonal (Code: D018931) Noxae (Code: D009676) antineoplastic agent (Code: CHEBI:35610) | |
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| aminopterin | Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Dihydrofolate reductase (Organism: Mus musculus, class: Enzyme, accessions: P00375, gene: Dhfr, swissprot: DYR_MOUSE) Folylpoly-gamma-glutamate synthetase (Organism: Mus musculus, class: Unclassified, accessions: P48760, gene: Fpgs, swissprot: FOLC_MOUSE) | A folic acid derivative used as a rodenticide that has been shown to be teratogenic. | Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) | 4KN1 4KY4 |
|
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| ceftezole | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| flumedroxone acetate | None | |
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| lopinavir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) CAAX prenyl protease 1 homolog (Organism: Mus musculus, class: Enzyme, accessions: Q80W54, gene: Zmpste24, swissprot: FACE1_MOUSE) Protease (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9YQ12, gene: protease, swissprot: Q9YQ12_9HIV1) | An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A. | Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Metabolic Side Effects of Drugs and Substances (Code: D065606) Protease Inhibitor (Code: N0000175889) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 3A Inhibitors (Code: N0000190114) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Protease Inhibitors (Code: D011480) antiviral drug (Code: CHEBI:36044) | 2000-09-15 FDA | 1MUI 1RV7 2O4S 2Q5K 2QHC 2RKF 2RKG 2Z54 3OGQ 4L1A |
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| tirofiban | Integrin alpha-IIb/beta-3 (Organism: Homo sapiens, class: Adhesion, accessions: P05106|P08514, gene: ITGA2B|ITGB3, swissprot: ITA2B_HUMAN|ITB3_HUMAN) | a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation, when administered intravenously inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner | Decreased Platelet Aggregation (Code: N0000008832) Platelet Aggregation Inhibitor (Code: N0000175578) Cardiovascular Agents (Code: D002317) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) fibrin modulating drug (Code: CHEBI:48676) platelet glycoprotein-IIb/IIIa receptor antagonist (Code: CHEBI:50433) anticoagulant (Code: CHEBI:50249) | 1998-05-14 FDA | 2VDM |
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| pentagestrone acetate | None | |
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| estradiol undecylate | None | |
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| sertindole | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | an antipsychotic drug with selective inhibitory effect on mesolimbic dopaminergic neurons and balanced inhibitory effects on central dopamine D2 and serotonin 5HT2 receptors as well as on alpha1-adrenergic receptors | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) second generation antipsychotic (Code: CHEBI:65191) serotonergic antagonist (Code: CHEBI:48279) alpha-adrenergic antagonist (Code: CHEBI:37890) H1-receptor antagonist (Code: CHEBI:37955) | 1996-05-23 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| trimethidinium | None | |
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| folic acid | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) | A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. | Growth Substances (Code: D006133) Hematinics (Code: D006397) Hematologic Agents (Code: D006401) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) B vitamin (Code: CHEBI:75769) | 1946-08-13 FDA | |
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| deflazacort | Deflazacort is a corticosteroid prodrug, whose active metabolite, 21-desDFZ, acts through the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects. The precise mechanism by which deflazacort exerts its therapeutic effects in patients with Duchenne muscular dystrophy is unknown. | Anti-Inflammatory Agents (Code: D000893) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) | 2017-02-09 FDA | |
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| troglitazone | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Glycogen [starch] synthase, liver (Organism: Homo sapiens, class: Enzyme, accessions: P54840, gene: GYS2, swissprot: GYS2_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) UDP-glucuronosyltransferase 1-6 (Organism: Homo sapiens, class: Enzyme, accessions: P19224, gene: UGT1A6, swissprot: UD16_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Indoleamine 2,3-dioxygenase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28776, gene: Ido1, swissprot: I23O1_MOUSE) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) | PPAR agonist formerly used for type II diabetes | Cytochrome P-450 CYP3A Inducers (Code: D065701) Hypoglycemic Agents (Code: D007004) Metabolic Side Effects of Drugs and Substances (Code: D065606) platelet aggregation inhibitor (Code: CHEBI:50427) anticoagulant (Code: CHEBI:50249) antineoplastic agent (Code: CHEBI:35610) hypoglycemic agent (Code: CHEBI:35526) vasodilator agent (Code: CHEBI:35620) anticonvulsant (Code: CHEBI:35623) | 1997-01-29 FDA | 2QM9 2VN0 |
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| dofetilide | Potassium voltage-gated channel subfamily H member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O95259, gene: KCNH1, swissprot: KCNH1_HUMAN) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Dofetilide show Vaughan Williams Class III antiarrhythmic activity. The mechanism of action is blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. At concentrations covering several orders of magnitude, dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors. | Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Potassium Channel Blockers (Code: D026902) anti-arrhythmia drug (Code: CHEBI:38070) | 1999-10-01 FDA | |
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| diphemanil | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | None | muscarinic antagonist (Code: CHEBI:48876) parasympatholytic (Code: CHEBI:50370) bronchodilator agent (Code: CHEBI:35523) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) | 1976-05-17 FDA | |
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| metacycline | A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | None FDA | |
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| mazipredone | was MH 1978-92 (see under PREDNISOLONE 1978-90); METHYLPIPERAZINYL DEOXYPREDNISOLONE was see DEPERSOLONE 1978-92; use PREDNISOLONE to search DEPERSOLONE 1978-92; a water-soluble, long-acting prednisolone derivative used topically for skin conditions & parenterally as a glucocorticoid | |
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| zuclopenthixol acetate | None | |
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| thiothixene | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) | A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. | Typical Antipsychotic (Code: N0000180182) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1967-07-24 FDA | |
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| prednival | None | |
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| raltegravir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) C-C chemokine receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P32246, gene: CCR1, swissprot: CCR1_HUMAN) Integrase (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q76353, gene: None, swissprot: Q76353_9HIV1) | Raltegravir inhibits the catalytic activity of HIV-1 integrase, an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the covalent insertion, or integration, of unintegrated linear HIV-1 DNA into the host cell genome preventing the formation of the HIV-1 provirus. The provirus is required to direct the production of progeny virus, so inhibiting integration prevents propagation of the viral infection. | Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor (Code: N0000175887) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Integrase Inhibitors (Code: D019428) | 2007-12-20 EMA 2007-10-12 FDA | 3L2V 3OYA 4MDA 4MDB |
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| tetracycline | 30S ribosomal protein S4 (Organism: Escherichia coli (strain K12), class: Ribosomal protein, accessions: P0A7V8, gene: rpsD, swissprot: RS4_ECOLI) 30S ribosomal protein S9 (Organism: Escherichia coli (strain K12), class: Ribosomal protein, accessions: P0A7X3, gene: rpsI, swissprot: RS9_ECOLI) | A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. | Tetracycline-class Antimicrobial (Code: N0000175505) Tetracyclines (Code: N0000007948) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) antibacterial drug (Code: CHEBI:36047) antiprotozoal drug (Code: CHEBI:35820) | 1953-11-19 FDA | |
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| doxycycline | 50S ribosomal protein L10 (Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809), class: Ribosomal protein, accessions: P15825, gene: rpl10, swissprot: RL10_HALMA) Tetracycline resistance protein, class B (Organism: Escherichia coli, class: Transporter, accessions: P02980, gene: tetA, swissprot: TCR2_ECOLX) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) Neutrophil collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P22894, gene: MMP8, swissprot: MMP8_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Stromelysin-1 (Organism: Homo sapiens, class: Enzyme, accessions: P08254, gene: MMP3, swissprot: MMP3_HUMAN) Collagenase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P45452, gene: MMP13, swissprot: MMP13_HUMAN) Matrilysin (Organism: Homo sapiens, class: Unclassified, accessions: P09237, gene: MMP7, swissprot: MMP7_HUMAN) | A synthetic tetracycline derivative with similar antimicrobial activity. | Tetracycline-class Drug (Code: N0000175882) Tetracyclines (Code: N0000007948) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antimalarial (Code: CHEBI:38068) antibacterial drug (Code: CHEBI:36047) | 1967-12-05 FDA | 2O7O 2XRL |
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| mitoxantrone | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) Serine/threonine-protein kinase pim-1 (Organism: Homo sapiens, class: Kinase, accessions: P11309, gene: PIM1, swissprot: PIM1_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) DNA-3-methyladenine glycosylase (Organism: Homo sapiens, class: Enzyme, accessions: P29372, gene: MPG, swissprot: 3MG_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63470, gene: Dyrk1a, swissprot: DYR1A_RAT) | An anthracenedione-derived antineoplastic agent. | Topoisomerase Inhibitor (Code: N0000175609) Analgesics (Code: D000700) Antineoplastic Agents (Code: D000970) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) analgesic (Code: CHEBI:35480) antineoplastic agent (Code: CHEBI:35610) | 1987-12-23 FDA | 2FUM 4G0V 4I41 |
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| emepronium | A muscarinic antagonist used mainly in the treatment of urinary syndromes. It is incompletely absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. | Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) Urological Agents (Code: D064804) | |
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| menatetrenone | Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) | None | Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) bone density conservation agent (Code: CHEBI:50646) | |
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| halometasone | None | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Dermatologic Agents (Code: D003879) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| glisentide | None | |
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| glipizide | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. | Sulfonylurea (Code: N0000175608) Sulfonylurea Compounds (Code: N0000008054) Hypoglycemic Agents (Code: D007004) hypoglycemic agent (Code: CHEBI:35526) | 1984-05-08 FDA | |
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| metopimazine | None | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) | |
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| thiopropazate | minor descriptor (66-72); major descriptor (73-85); on-line search PHENOTHIAZINES (66-85); Index Medicus search PHENOTHIAZINES (66-72); THIOPROPAZATE (73-85); RN given refers to parent cpd | phenothiazine antipsychotic drug (Code: CHEBI:37930) dopaminergic antagonist (Code: CHEBI:48561) | |
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| spiclomazine | None | |
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| baicalin | GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) Prolyl endopeptidase (Organism: Homo sapiens, class: Enzyme, accessions: P48147, gene: PREP, swissprot: PPCE_HUMAN) Cyclin-dependent kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P06493, gene: CDK1, swissprot: CDK1_HUMAN) | has iron chelating activity; chemical component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis); do not confuse with baicalein | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Asthmatic Agents (Code: D018927) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sensory System Agents (Code: D018689) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) prodrug (Code: CHEBI:50266) | 4H2B 4Q2V |
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| fluocortin butyl | None | Adrenal Cortex Hormones (Code: D000305) Dermatologic Agents (Code: D003879) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| dalfopristin | component of RP-59500 | Streptogramin Antibacterial (Code: N0000175502) Streptogramins (Code: N0000011418) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1999-09-21 FDA | |
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| carpipramine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| thioproperazine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | phenothiazine antipsychotic drug (Code: CHEBI:37930) | |
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| gefitinib | Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Tubulin alpha-1A chain (Organism: Rattus norvegicus, class: Structural, accessions: P68370, gene: Tuba1a, swissprot: TBA1A_RAT) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Casein kinase I isoform delta (Organism: Homo sapiens, class: Kinase, accessions: P48730, gene: CSNK1D, swissprot: KC1D_HUMAN) Serine/threonine-protein kinase pim-3 (Organism: Homo sapiens, class: Kinase, accessions: Q86V86, gene: PIM3, swissprot: PIM3_HUMAN) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Mus musculus, class: Kinase, accessions: Q3U3Q1, gene: Ulk3, swissprot: ULK3_MOUSE) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Organism: Homo sapiens, class: Kinase, accessions: Q8TBX8, gene: PIP4K2C, swissprot: PI42C_HUMAN) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Mitogen-activated protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P31152, gene: MAPK4, swissprot: MK04_HUMAN) Mitogen-activated protein kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q16659, gene: MAPK6, swissprot: MK06_HUMAN) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) Serine/threonine-protein kinase NLK (Organism: Homo sapiens, class: Kinase, accessions: Q9UBE8, gene: NLK, swissprot: NLK_HUMAN) | Gefitinib reversibly inhibits the kinase activity of wild-type and certain activating mutations of EGFR, preventing autophosphorylation of tyrosine residues associated with the receptor, thereby inhibiting further downstream signalling and blocking EGFR-dependent proliferation. | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2003-05-05 FDA | |
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| propyliodone | Radiopaque medium usually in oil; used in bronchography. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | None FDA | |
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| teclozan | None | |
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| tioclomarol | None | |
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| ampiroxicam | prodrug of piroxicam; structure given in first source | analgesic (Code: CHEBI:35480) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antirheumatic drug (Code: CHEBI:35842) prodrug (Code: CHEBI:50266) | |
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| sisomicin | 30S ribosomal protein S12 (Organism: Escherichia coli (strain K12), class: Cytosolic other, accessions: P0A7S3, gene: rpsL, swissprot: RS12_ECOLI) | Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS). | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1977-01-01 YEAR INTRODUCED | 4F8U 4F8V 5C4L 5U08 6BBZ 6BC3 6BC7 |
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| aripiprazole | D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) | An antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. | Atypical Antipsychotic (Code: N0000175430) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) second generation antipsychotic (Code: CHEBI:65191) H1-receptor antagonist (Code: CHEBI:37955) serotonergic agonist (Code: CHEBI:35941) | 2004-06-04 EMA 2002-11-15 FDA | |
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| algestone acetophenide | A progesterone that has been used in ESTRUS SYNCHRONIZATION and has been evaluated as an injectable contraceptive in combination with estradiol enanthate. It is also used therapeutically as a topical anti-inflammatory and is applied topically in the treatment of ACNE. | Anti-Inflammatory Agents (Code: D000893) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Oral (Code: D003276) Contraceptives, Oral, Synthetic (Code: D003280) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) Reproductive Control Agents (Code: D012102) anti-inflammatory drug (Code: CHEBI:35472) synthetic oral contraceptive (Code: CHEBI:49326) | |
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| tolvaptan | Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Vasopressin V1a receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560, gene: Avpr1a, swissprot: V1AR_RAT) Vasopressin V2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q00788, gene: Avpr2, swissprot: V2R_RAT) | None | Antidiuretic Hormone Receptor Antagonists (Code: D065092) Natriuretic Agents (Code: D045283) Vasopressin V2 Receptor Antagonist (Code: N0000193181) Vasopressin V2 Receptor Antagonists (Code: N0000193178) | 2015-02-26 EMA 2009-05-19 FDA | |
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| glisoxepide | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | oral sulfonylurea hypoglycemic agent which stimulates insulin secretion; minor descriptor (75-85); on-line & Index Medicus search SULFONYLUREA COMPOUNDS (75-85); RN given refers to parent cpd | |
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| sofalcone | None | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | |
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| tiomesterone | None | |
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| phytomenadione | A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K. | Increased Prothrombin Activity (Code: N0000175965) Reversed Anticoagulation Activity (Code: N0000175982) Vitamin K (Code: N0000006290) Warfarin Reversal Agent (Code: N0000175966) Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Fibrin Modulating Agents (Code: D050299) Growth Substances (Code: D006133) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Micronutrients (Code: D018977) Vitamins (Code: D014815) | 2000-05-18 FDA | 1C51 1JB0 1QZV 2O01 2PPS 2WSC 2WSE 2WSF 3LW5 3PCQ 4FE1 4KT0 4L6V 4RKU 4XK8 4Y28 5L8R 5OY0 5ZF0 6FOS |
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| doxazosin | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A prazosin-related compound that is a selective alpha-1-adrenergic blocker. | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic antagonist (Code: CHEBI:37890) antineoplastic agent (Code: CHEBI:35610) vasodilator agent (Code: CHEBI:35620) antihyperplasia drug (Code: CHEBI:59844) | 1990-11-02 FDA | |
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| dibekacin | Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Organism: Escherichia coli, class: Enzyme, accessions: O32553, gene: mphB, swissprot: O32553_ECOLX) | Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1979-01-01 YEAR INTRODUCED | 6CAV |
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| homofenazine | None | phenothiazine antipsychotic drug (Code: CHEBI:37930) anxiolytic drug (Code: CHEBI:35474) | |
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| cabergoline | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) | also acts as prolactin antagonist | Ergolines (Code: N0000007618) Ergot Derivative (Code: N0000175827) Anti-Dyskinesia Agents (Code: D018726) Antineoplastic Agents (Code: D000970) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) dopamine agonist (Code: CHEBI:51065) antiparkinson drug (Code: CHEBI:48407) antineoplastic agent (Code: CHEBI:35610) | 1996-12-23 FDA | |
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| glucosaminylmuramyl dipeptide | None | |
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| mannite hexanitrate | None | |
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| fluocinolone acetonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732) | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) antipruritic drug (Code: CHEBI:59683) anti-inflammatory drug (Code: CHEBI:35472) | 1963-02-15 FDA | |
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| delapril | Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | |
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| repaglinide | Solute carrier organic anion transporter family member 1B1 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y6L6, gene: SLCO1B1, swissprot: SO1B1_HUMAN) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) ATP-binding cassette sub-family C member 8 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428, gene: ABCC8, swissprot: ABCC8_HUMAN) | None | Glinide (Code: N0000175428) Potassium Channel Antagonists (Code: N0000175448) Hypoglycemic Agents (Code: D007004) | 1997-12-22 FDA | |
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| diphenoxylate | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Potassium voltage-gated channel subfamily A member 3 (Organism: Homo sapiens, class: Ion channel, accessions: P22001, gene: KCNA3, swissprot: KCNA3_HUMAN) | A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. | Antidiarrheal (Code: N0000178374) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Antidiarrheals (Code: D000930) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Gastrointestinal Agents (Code: D005765) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) antidiarrhoeal drug (Code: CHEBI:55323) | 1960-09-15 FDA | |
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| butropium | None | |
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| cefixime | Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) drug allergen (Code: CHEBI:88188) antibacterial drug (Code: CHEBI:36047) | 1989-04-28 FDA | 4KOU |
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| floxacillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) | Antibiotic analog of CLOXACILLIN. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1962-01-01 YEAR INTRODUCED | |
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| methotrexate | Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Leishmania major, class: Enzyme, accessions: P07382, gene: None, swissprot: DRTS_LEIMA) Thymidylate synthase (Organism: Escherichia coli, class: Enzyme, accessions: C3SWJ7, gene: thyA, swissprot: C3SWJ7_ECOLX) Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Dihydrofolate reductase (Organism: Enterococcus faecium, class: Unclassified, accessions: P00380, gene: folA, swissprot: DYR_ENTFC) Thymidylate synthase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00469, gene: thyA, swissprot: TYSY_LACCA) Dihydrofolate reductase (Organism: Bos taurus, class: Unclassified, accessions: P00376, gene: DHFR, swissprot: DYR_BOVIN) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) Dihydrofolate reductase (Organism: Bacillus anthracis, class: Enzyme, accessions: Q81R22, gene: dfrA, swissprot: Q81R22_BACAN) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Thymidylate synthase (Organism: Mus musculus, class: Enzyme, accessions: P07607, gene: Tyms, swissprot: TYSY_MOUSE) Dihydrofolate reductase (Organism: Mus musculus, class: Enzyme, accessions: P00375, gene: Dhfr, swissprot: DYR_MOUSE) Dihydrofolate reductase (Organism: Gallus gallus, class: Enzyme, accessions: P00378, gene: DHFR, swissprot: DYR_CHICK) Folylpolyglutamate synthase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q05932, gene: FPGS, swissprot: FOLC_HUMAN) Pteridine reductase 1 (Organism: Leishmania major, class: Enzyme, accessions: Q01782, gene: PTR1, swissprot: PTR1_LEIMA) Folate transporter 1 (Organism: Homo sapiens, class: Unclassified, accessions: P41440, gene: SLC19A1, swissprot: S19A1_HUMAN) Folate receptor alpha (Organism: Homo sapiens, class: Membrane receptor, accessions: P15328, gene: FOLR1, swissprot: FOLR1_HUMAN) Proton-coupled folate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q96NT5, gene: SLC46A1, swissprot: PCFT_HUMAN) Folate receptor beta (Organism: Homo sapiens, class: Membrane receptor, accessions: P14207, gene: FOLR2, swissprot: FOLR2_HUMAN) | An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. | Folate Analog Metabolic Inhibitor (Code: N0000175584) Folic Acid Metabolism Inhibitors (Code: N0000000111) Abortifacient Agents (Code: D000019) Abortifacient Agents, Nonsteroidal (Code: D000020) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Antirheumatic Agents (Code: D018501) Dermatologic Agents (Code: D003879) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reproductive Control Agents (Code: D012102) | 1953-12-07 FDA | 1AXW 1D1G 1DDR 1DDS 1DF7 1DHI 1DHJ 1DLS 1DRA 1DRB 1DRE 1E7W 1MXF 1P33 1RA3 1RB3 1RG7 1RH3 1RX3 1TDR 1U70 1U72 2C7V 2DRC 2OIP 2QK8 3CD2 3CL9 3DAT 3DAU 3DFR 3DRC 3EIG 3HJ3 3IA4 3IX9 3QXT 3QXV 3TQ9 4DFR 4GH8 4KN0 4KY8 4L6H 4L8F 4L8W 4OCX 4P66 4P68 4Q0D 4QI9 5HI6 5J7W 5X66 |
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| cetrimonium | Dynamin-1 (Organism: Homo sapiens, class: Structural, accessions: Q05193, gene: DNM1, swissprot: DYN1_HUMAN) | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Detergents (Code: D003902) Surface-Active Agents (Code: D013501) | 1KPG 1TPY 3B00 3HF0 3P73 5HXW |
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| ribostamycin | A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1M4G 1S3Z 2BUE 2ET5 2FCZ 3C3Z 3DVV 5IQD 6C5U |
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| carfecillin | The phenyl ester of CARBENICILLIN that, upon oral administration, is broken down in the intestinal mucosa to the active antibacterial. It is used for urinary tract infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) | |
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| cefazolin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1973-10-04 FDA | |
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| verapamil | Voltage-dependent L-type calcium channel subunit alpha-1S (Organism: Homo sapiens, class: Ion channel, accessions: Q13698, gene: CACNA1S, swissprot: CAC1S_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Potassium voltage-gated channel subfamily C member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q96PR1, gene: KCNC2, swissprot: KCNC2_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Potassium voltage-gated channel subfamily A member 7 (Organism: Homo sapiens, class: Ion channel, accessions: Q96RP8, gene: KCNA7, swissprot: KCNA7_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Potassium voltage-gated channel subfamily A member 10 (Organism: Homo sapiens, class: Ion channel, accessions: Q16322, gene: KCNA10, swissprot: KCA10_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) G protein-activated inward rectifier potassium channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: P48051, gene: KCNJ6, swissprot: KCNJ6_HUMAN) Equilibrative nucleoside transporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q7RTT9, gene: SLC29A4, swissprot: S29A4_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Oryctolagus cuniculus, class: Ion channel, accessions: P15381, gene: CACNA1C, swissprot: CAC1C_RABIT) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1S (Organism: Rattus norvegicus, class: Ion channel, accessions: Q02485, gene: Cacna1s, swissprot: CAC1S_RAT) Translocator protein (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P16257, gene: Tspo, swissprot: TSPO_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Chloroquine resistance transporter (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q9N623, gene: CRT, swissprot: CRT_PLAFA) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Voltage-gated L-type calcium channel (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002|P27732|Q02485, gene: Cacna1c|Cacna1d|Cacna1s, swissprot: CAC1C_RAT|CAC1D_RAT|CAC1S_RAT) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002, gene: Cacna1c, swissprot: CAC1C_RAT) Potassium voltage-gated channel subfamily A member 3 (Organism: Homo sapiens, class: Ion channel, accessions: P22001, gene: KCNA3, swissprot: KCNA3_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Sus scrofa, class: GPCR, accessions: P06199, gene: CHRM2, swissprot: ACM2_PIG) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Potassium voltage-gated channel subfamily C member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P22462, gene: Kcnc2, swissprot: KCNC2_RAT) Two pore calcium channel protein 2 (Organism: Homo sapiens, class: Unclassified, accessions: Q8NHX9, gene: TPCN2, swissprot: TPC2_HUMAN) Two pore calcium channel protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9ULQ1, gene: TPCN1, swissprot: TPC1_HUMAN) | A calcium channel blocker that is a class IV anti-arrhythmia agent. | Calcium Channel Antagonists (Code: N0000000069) Calcium Channel Blocker (Code: N0000175566) Anti-Arrhythmia Agents (Code: D000889) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A Inhibitors (Code: N0000190114) P-Glycoprotein Inhibitors (Code: N0000185503) Vasodilator Agents (Code: D014665) anti-arrhythmia drug (Code: CHEBI:38070) vasodilator agent (Code: CHEBI:35620) antihypertensive agent (Code: CHEBI:35674) | 1981-08-12 FDA | 5C6O 5C6P |
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| lindane | Gamma-aminobutyric acid receptor subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: P28472, gene: GABRB3, swissprot: GBRB3_HUMAN) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) Gamma-aminobutyric acid receptor subunit rho-1 (Organism: Homo sapiens, class: Ion channel, accessions: P24046, gene: GABRR1, swissprot: GBRR1_HUMAN) Gamma-aminobutyric acid receptor subunit beta (Organism: Musca domestica, class: Ion channel, accessions: Q75NA5, gene: Rdl, swissprot: GBRB_MUSDO) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) GABA A receptor alpha-1/beta-1/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18505|P18507, gene: GABRA1|GABRB1|GABRG2, swissprot: GBRA1_HUMAN|GBRB1_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-6/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|Q16445, gene: GABRA6|GABRB3|GABRG2, swissprot: GBRA6_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor (Organism: Tetranychus urticae, class: Ion channel, accessions: H9U2V9|H9U2W0|H9U2W1, gene: Rdl1|Rdl2|Rdl3, swissprot: H9U2V9_TETUR|H9U2W0_TETUR|H9U2W1_TETUR) GABA-A receptor (Organism: Pediculus humanus subsp. corporis, class: Ion channel, accessions: E0V9W2|E0VY07|E0W492, gene: None, swissprot: E0V9W2_PEDHC|E0VY07_PEDHC|E0W492_PEDHC) | An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer. | rodenticide (Code: CHEBI:33288) agrochemical (Code: CHEBI:33286) fungicide (Code: CHEBI:24127) pediculicide (Code: CHEBI:38706) Insecticides (Code: D007306) Pesticides (Code: D010575) | 1974-12-19 FDA | |
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| sitaxentan | Endothelin-1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P26684, gene: Ednra, swissprot: EDNRA_RAT) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) Endothelin B receptor (Organism: Homo sapiens, class: GPCR, accessions: P24530, gene: EDNRB, swissprot: EDNRB_HUMAN) | endothelin A receptor antagonist | Endothelin Receptor Antagonists (Code: D065128) | 2006-08-10 EMA | |
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| fenticonazole | None | Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) antibacterial drug (Code: CHEBI:36047) | |
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| cefotaxime | Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) Peptidoglycan synthase FtsI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD68, gene: ftsI, swissprot: FTSI_ECOLI) Penicillin-binding protein 2 (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD65, gene: mrdA, swissprot: PBP2_ECOLI) Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Beta-lactamase (Organism: Acinetobacter baumannii, class: Enzyme, accessions: B2ZTR6, gene: None, swissprot: B2ZTR6_ACIBA) Beta-lactamase (Organism: Acinetobacter baumannii, class: Enzyme, accessions: D6NSM8, gene: ampC, swissprot: D6NSM8_ACIBA) | Semisynthetic broad-spectrum cephalosporin. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) drug allergen (Code: CHEBI:88188) antibacterial drug (Code: CHEBI:36047) | 1981-03-11 FDA | 3HLW 4KOT 4PM5 4PM7 4PM9 5NZY 6C79 |
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| lacidipine | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| clevidipine | Voltage-dependent L-type calcium channel subunit alpha-1D (Organism: Homo sapiens, class: Ion channel, accessions: Q01668, gene: CACNA1D, swissprot: CAC1D_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) | a calcium channel blocker and antihypertensive agent | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | 2008-08-01 FDA | |
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| riboflavin phosphate | A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues. | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | 1953-02-20 FDA | |
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| delavirdine | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Malate dehydrogenase cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P40925, gene: MDH1, swissprot: MDHC_HUMAN) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175463) Non-Nucleoside Analog (Code: N0000175460) Non-Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009948) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) antiviral drug (Code: CHEBI:36044) | 1997-04-04 FDA | 1KLM |
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| xenytropium | None | |
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| detajmium | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| testosterone undecanoate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | None | Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 2014-03-05 FDA | |
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| minocycline | 30S ribosomal protein S9 (Organism: Chlamydia pneumoniae, class: Unclassified, accessions: Q9Z8T8, gene: rpsI, swissprot: RS9_CHLPN) 30S ribosomal protein S4 (Organism: Chlamydia pneumoniae, class: Unclassified, accessions: Q9Z7H2, gene: rpsD, swissprot: RS4_CHLPN) Tetracycline resistance protein, class B (Organism: Escherichia coli, class: Transporter, accessions: P02980, gene: tetA, swissprot: TCR2_ECOLX) | A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections. | Tetracycline-class Drug (Code: N0000175882) Tetracyclines (Code: N0000007948) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1971-06-30 FDA | 2DRD 2WQ5 2XPV 3AOD 3V3N 4A99 4AC0 4DX5 4U8V 4U8Y 4U95 5ENT |
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| ormeloxifene | A non-steroidal anti-fertility agent with anti-hormonal properties. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Contraceptives, Postcoital (Code: D003281) Contraceptives, Postcoital, Synthetic (Code: D003283) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) | |
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| azimilide | Potassium voltage-gated channel subfamily KQT member 1 (Organism: Mus musculus, class: Unclassified, accessions: P97414, gene: Kcnq1, swissprot: KCNQ1_MOUSE) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Cavia porcellus, class: Ion channel, accessions: O08703, gene: KCNH2, swissprot: KCNH2_CAVPO) Potassium voltage-gated channel subfamily KQT member 1 (Organism: Cavia porcellus, class: Ion channel, accessions: O70344, gene: KCNQ1, swissprot: KCNQ1_CAVPO) | None | Anti-Arrhythmia Agents (Code: D000889) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| raltitrexed | Folate receptor alpha (Organism: Homo sapiens, class: Membrane receptor, accessions: P15328, gene: FOLR1, swissprot: FOLR1_HUMAN) Thymidylate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A884, gene: thyA, swissprot: TYSY_ECOLI) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Toxoplasma gondii, class: Enzyme, accessions: Q07422, gene: None, swissprot: DRTS_TOXGO) Thymidylate synthase (Organism: Escherichia coli, class: Enzyme, accessions: C3SWJ7, gene: thyA, swissprot: C3SWJ7_ECOLX) Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Thymidylate synthase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00469, gene: thyA, swissprot: TYSY_LACCA) Thymidylate synthase (Organism: Rattus norvegicus, class: Enzyme, accessions: P45352, gene: Tyms, swissprot: TYSY_RAT) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Thymidylate synthase (Organism: Mus musculus, class: Enzyme, accessions: P07607, gene: Tyms, swissprot: TYSY_MOUSE) Folate transporter 1 (Organism: Homo sapiens, class: Unclassified, accessions: P41440, gene: SLC19A1, swissprot: S19A1_HUMAN) Proton-coupled folate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q96NT5, gene: SLC46A1, swissprot: PCFT_HUMAN) Folate receptor beta (Organism: Homo sapiens, class: Membrane receptor, accessions: P14207, gene: FOLR2, swissprot: FOLR2_HUMAN) | None | Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) Noxae (Code: D009676) | 1996-01-01 YEAR INTRODUCED | 1HVY 1I00 1RTS 2KCE 2TSR 3NRR 4EB4 4FOX 4GTB 4IQQ 5H3A 5NOO 5X5Q |
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| prifinium | None | |
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| fumagillin | Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) | empirical formula C25-27H34-37O7, a monoester of decatetraenedioic acid (HOOC-(C=CH)4-COOH and fumagillin (C16-17H25-26O3); FR 65814 lacks the fat | Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) angiogenesis inhibitor (Code: CHEBI:48422) antiprotozoal drug (Code: CHEBI:35820) antibacterial drug (Code: CHEBI:36047) | |
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| astemizole | Potassium voltage-gated channel subfamily H member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O95259, gene: KCNH1, swissprot: KCNH1_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) Somatostatin receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P35346, gene: SSTR5, swissprot: SSR5_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Protein farnesyltransferase (Organism: Bos taurus, class: Enzyme, accessions: P29702|P49355, gene: FNTA|FNTB, swissprot: FNTA_BOVIN|FNTB_BOVIN) Polycomb protein EED (Organism: Homo sapiens, class: Unclassified, accessions: O75530, gene: EED, swissprot: EED_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects. | Anti-Allergic Agents (Code: D018926) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) | 1988-12-31 FDA | |
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| prednisolone tebutate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1956-07-25 FDA | |
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| fluazacort | None | |
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| cerivastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) | cerivastatin is the ((E)-(+))-isomer; structure given in first source | Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 1997-06-26 FDA | |
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| fenoverine | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| oxytetracycline | 30S ribosomal protein S9 (Organism: Escherichia coli (strain K12), class: Ribosomal protein, accessions: P0A7X3, gene: rpsI, swissprot: RS9_ECOLI) 30S ribosomal protein S4 (Organism: Escherichia coli (strain K12), class: Ribosomal protein, accessions: P0A7V8, gene: rpsD, swissprot: RS4_ECOLI) | A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions. | Tetracycline-class Antimicrobial (Code: N0000175505) Tetracyclines (Code: N0000007948) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1964-09-08 FDA | 2XPW |
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| prednisolone succinate | None | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| cefotiam hexetil | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) prodrug (Code: CHEBI:50266) | |
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| hydrocortisone aceponate | None | |
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| loxiglumide | Cholecystokinin receptor type A (Organism: Homo sapiens, class: GPCR, accessions: P32238, gene: CCKAR, swissprot: CCKAR_HUMAN) Cholecystokinin receptor type A (Organism: Rattus norvegicus, class: GPCR, accessions: P30551, gene: Cckar, swissprot: CCKAR_RAT) | cholecystokinin receptor antagonist; RN refers to (+-)-isomer | Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| dexloxiglumide | Cholecystokinin receptor type A (Organism: Homo sapiens, class: GPCR, accessions: P32238, gene: CCKAR, swissprot: CCKAR_HUMAN) | a CCK receptor antagonist; structure given in first source | |
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| prulifloxacin | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| bunamiodyl | None | |
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| loprazolam | GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-2/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P47869, gene: GABRA2|GABRB3|GABRG2, swissprot: GBRA2_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-3/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P34903, gene: GABRA3|GABRB3|GABRG2, swissprot: GBRA3_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-5/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P28472|P31644, gene: GABRA5|GABRB3|GABRG2, swissprot: GBRA5_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) | None | 1983-01-01 YEAR INTRODUCED | |
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| lenampicillin | None | |
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| cinnoxicam | None | |
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| azlocillin | Penicillin-binding protein (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: Q07806|Q51504|Q51505|Q9X6V3|Q9X6V7|Q9X6W0, gene: dacA|mrcA|pbpA|pbpB|pbpC|ponB, swissprot: PBPA_PSEAE|Q51504_PSEAI|Q51505_PSEAI|Q9X6V3_PSEAI|Q9X6V7_PSEAI|Q9X6W0_PSEAI) | A semisynthetic ampicillin-derived acylureido penicillin. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1982-09-03 FDA | |
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| cefalexin pivoxil | None | |
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| pimozide | Ubiquitin carboxyl-terminal hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O94782, gene: USP1, swissprot: UBP1_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1I (Organism: Homo sapiens, class: Ion channel, accessions: Q9P0X4, gene: CACNA1I, swissprot: CAC1I_HUMAN) Potassium voltage-gated channel subfamily A member 10 (Organism: Homo sapiens, class: Ion channel, accessions: Q16322, gene: KCNA10, swissprot: KCA10_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Rattus norvegicus, class: Unclassified, accessions: O54898, gene: Cacna1g, swissprot: CAC1G_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) G protein-activated inward rectifier potassium channel 2 (Organism: Mus musculus, class: Unclassified, accessions: P48542, gene: Kcnj6, swissprot: KCNJ6_MOUSE) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Rattus norvegicus, class: Unclassified, accessions: Q9EQ60, gene: Cacna1h, swissprot: CAC1H_RAT) | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403) | Typical Antipsychotic (Code: N0000180182) Anti-Dyskinesia Agents (Code: D018726) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) H1-receptor antagonist (Code: CHEBI:37955) serotonergic antagonist (Code: CHEBI:48279) antidyskinesia agent (Code: CHEBI:66956) dopaminergic antagonist (Code: CHEBI:48561) first generation antipsychotic (Code: CHEBI:65190) | 1984-07-31 FDA | |
||
| tobuterol | None | |
|||||
| bitolterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) | a short-acting beta2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-2 Receptor Agonists (Code: D058666) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) bronchodilator agent (Code: CHEBI:35523) anti-asthmatic drug (Code: CHEBI:49167) beta-adrenergic agonist (Code: CHEBI:35522) prodrug (Code: CHEBI:50266) | 1984-12-28 FDA | |
||
| cefatrizine | Orally active semisynthetic cephalosporin antibiotic with broad-spectrum activity. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | |
||||
| cefamandole | Solute carrier family 15 member 1 (Organism: Homo sapiens, class: Transporter, accessions: P46059, gene: SLC15A1, swissprot: S15A1_HUMAN) | Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 3NY4 |
|
||
| tixocortol | 21-thiol derivative of hydrocortisone | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anti-Allergic Agents (Code: D018926) | |
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| tafenoquine | None | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | |
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| dibrompropamidine | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Urokinase-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00749, gene: PLAU, swissprot: UROK_HUMAN) Acrosin (Organism: Sus scrofa, class: Unclassified, accessions: P08001, gene: ACR, swissprot: ACRO_PIG) Suppressor of tumorigenicity 14 protein (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y5Y6, gene: ST14, swissprot: ST14_HUMAN) | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | |
|||
| pivampicillin | Pivalate ester analog of AMPICILLIN. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) prodrug (Code: CHEBI:50266) | |
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| micronomicin | DE 020 & DE 020 eyedrops both consist of KW 1062, benzalkonium chloride, sodium chloride, sodium hydroxide & distilled water pH 7.4; RN given refers to parent cpd; see also record for gentamicin C; structure | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
||||
| asulacrine | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) | derivative of amsacrine; structure given in first source | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| sorafenib | Cyclin-dependent kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P49336, gene: CDK8, swissprot: CDK8_HUMAN) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Muscle, skeletal receptor tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: O15146, gene: MUSK, swissprot: MUSK_HUMAN) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Myosin-IIIb (Organism: Homo sapiens, class: Kinase, accessions: Q8WXR4, gene: MYO3B, swissprot: MYO3B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Cyclin-dependent kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q96Q40, gene: CDK15, swissprot: CDK15_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Danio rerio, class: Kinase, accessions: Q5GIT4, gene: kdr, swissprot: VGFR2_DANRE) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Cyclin-dependent kinase-like 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVW4, gene: CDKL3, swissprot: CDKL3_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) Mitogen-activated protein kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q8TD08, gene: MAPK15, swissprot: MK15_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Mus musculus, class: Kinase, accessions: P00520, gene: Abl1, swissprot: ABL1_MOUSE) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Ephrin type-A receptor 7 (Organism: Homo sapiens, class: Kinase, accessions: Q15375, gene: EPHA7, swissprot: EPHA7_HUMAN) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) LIM domain kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53667, gene: LIMK1, swissprot: LIMK1_HUMAN) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Tyrosine-protein kinase Srms (Organism: Homo sapiens, class: Kinase, accessions: Q9H3Y6, gene: SRMS, swissprot: SRMS_HUMAN) Casein kinase I isoform alpha (Organism: Homo sapiens, class: Kinase, accessions: P48729, gene: CSNK1A1, swissprot: KC1A_HUMAN) Cyclin-dependent kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q00526, gene: CDK3, swissprot: CDK3_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Cyclin-dependent kinase 17 (Organism: Homo sapiens, class: Kinase, accessions: Q00537, gene: CDK17, swissprot: CDK17_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) Cyclin-dependent kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: O94921, gene: CDK14, swissprot: CDK14_HUMAN) TGF-beta receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: P37173, gene: TGFBR2, swissprot: TGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Mitogen-activated protein kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O15264, gene: MAPK13, swissprot: MK13_HUMAN) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) Ephrin type-B receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29323, gene: EPHB2, swissprot: EPHB2_HUMAN) Mitogen-activated protein kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q15759, gene: MAPK11, swissprot: MK11_HUMAN) LIM domain kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P53671, gene: LIMK2, swissprot: LIMK2_HUMAN) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Cyclin-dependent-like kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q00535, gene: CDK5, swissprot: CDK5_HUMAN) Cyclin-dependent kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q9BWU1, gene: CDK19, swissprot: CDK19_HUMAN) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) Serine/threonine-protein kinase NLK (Organism: Homo sapiens, class: Kinase, accessions: Q9UBE8, gene: NLK, swissprot: NLK_HUMAN) Mitogen-activated protein kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: P53778, gene: MAPK12, swissprot: MK12_HUMAN) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Purine nucleoside phosphorylase (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q8T9Z7, gene: PNP, swissprot: Q8T9Z7_PLAFA) Platelet-derived growth factor receptor beta (Organism: Mus musculus, class: Unclassified, accessions: P05622, gene: Pdgfrb, swissprot: PGFRB_MOUSE) Vascular endothelial growth factor receptor 3 (Organism: Mus musculus, class: Unclassified, accessions: P35917, gene: Flt4, swissprot: VGFR3_MOUSE) | inhibits tumor cell proliferation and angiogenesis by targeting RAF KINASES and VEGF RECEPTORS; multikinase inhibitor that targets serine/threonine and receptor tyrosine kinases to decrease tumor growth and angiogenesis; FDA approved orphan drug indication for hepatocellular carcinoma in 2006 | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) angiogenesis inhibitor (Code: CHEBI:48422) | 2005-12-20 FDA | 1UWH 1UWJ 3GCS 3HEG 3RGF 3WZE 4ASD 5HI2 |
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| demeclocycline | 30S ribosomal protein S4 (Organism: Escherichia coli (strain K12), class: Ribosomal protein, accessions: P0A7V8, gene: rpsD, swissprot: RS4_ECOLI) 30S ribosomal protein S9 (Organism: Escherichia coli (strain K12), class: Ribosomal protein, accessions: P0A7X3, gene: rpsI, swissprot: RS9_ECOLI) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) | The tetracyclines are primarily bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis. The tetracyclines, including demeclocycline have a similar antimicrobial spectrum of activity against a wide range of gram-negative and gram-positive organisms. | Tetracycline-class Antimicrobial (Code: N0000175505) Tetracyclines (Code: N0000007948) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1960-01-14 FDA | |
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| bacampicillin | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract; RN given refers to parent cpd; structure | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) prodrug (Code: CHEBI:50266) | 1980-12-22 FDA | |
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| sulprostone | Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Mus musculus, class: GPCR, accessions: P30557, gene: Ptger3, swissprot: PE2R3_MOUSE) Prostaglandin E2 receptor EP3 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P34980, gene: Ptger3, swissprot: PE2R3_RAT) Prostaglandin E2 receptor EP1 subtype (Organism: Mus musculus, class: GPCR, accessions: P35375, gene: Ptger1, swissprot: PE2R1_MOUSE) Prostaglandin E2 receptor EP1 subtype (Organism: Rattus norvegicus, class: Unclassified, accessions: P70597, gene: Ptger1, swissprot: PE2R1_RAT) | None | Abortifacient Agents (Code: D000019) Abortifacient Agents, Nonsteroidal (Code: D000020) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Menstruation-Inducing Agents (Code: D008600) Reproductive Control Agents (Code: D012102) | |
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| cisapride | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) 5-hydroxytryptamine receptor 2A (Organism: Bos taurus, class: GPCR, accessions: Q75Z89, gene: HTR2A, swissprot: 5HT2A_BOVIN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) Serotonin 3 (5-HT3) receptor (Organism: Homo sapiens, class: Ion channel, accessions: A5X5Y0|O95264|P46098|Q70Z44|Q8WXA8, gene: HTR3A|HTR3B|HTR3C|HTR3D|HTR3E, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN|5HT3C_HUMAN|5HT3D_HUMAN|5HT3E_HUMAN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) 5-hydroxytryptamine receptor 4 (Organism: Mus musculus, class: Unclassified, accessions: P97288, gene: Htr4, swissprot: 5HT4R_MOUSE) | A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed) | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) serotonergic agonist (Code: CHEBI:35941) anti-ulcer drug (Code: CHEBI:49201) gastrointestinal drug (Code: CHEBI:55324) | 1993-07-29 FDA | |
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| carumonam | Peptidoglycan synthase FtsI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD68, gene: ftsI, swissprot: FTSI_ECOLI) | None | antibacterial drug (Code: CHEBI:36047) | 1988-01-01 YEAR INTRODUCED | |
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| benfotiamine | None | immunological adjuvant (Code: CHEBI:50847) nutraceutical (Code: CHEBI:50733) protective agent (Code: CHEBI:50267) | |
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| spirapril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P47820, gene: Ace, swissprot: ACE_RAT) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1994-12-29 FDA | |
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| loteprednol etabonate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | An androstadiene derivative corticosteroid that is used as an ANTI-ALLERGIC AGENT for the treatment of inflammatory and allergic eye conditions. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Allergic Agents (Code: D018926) | 1998-03-09 FDA | |
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| edatrexate | Folylpolyglutamate synthase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q05932, gene: FPGS, swissprot: FOLC_HUMAN) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) Dihydrofolate reductase (Organism: Mus musculus, class: Enzyme, accessions: P00375, gene: Dhfr, swissprot: DYR_MOUSE) | None | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) | 1978-01-01 YEAR INTRODUCED | |
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| tobramycin | Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Organism: Escherichia coli, class: Enzyme, accessions: O32553, gene: mphB, swissprot: O32553_ECOLX) | An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species. | Aminoglycoside Antibacterial (Code: N0000175477) Aminoglycosides (Code: N0000007853) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1975-06-11 FDA | 1LC4 1M4D 3SG8 3VET 4EBK 4EVY 4JD6 4LFC 4XJE 5CFS |
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| buprenorphine | Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Nociceptin receptor (Organism: Homo sapiens, class: GPCR, accessions: P41146, gene: OPRL1, swissprot: OPRX_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) | A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. | Partial Opioid Agonist (Code: N0000175689) Partial Opioid Agonists (Code: N0000175685) Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotic Antagonists (Code: D009292) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) kappa-opioid receptor agonist (Code: CHEBI:59282) delta-opioid receptor antagonist (Code: CHEBI:59283) | 1981-12-29 FDA | |
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| oxetacaine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | isolated from bioactive leaf extracts of Rollinia mucosa | Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| tiropramide | None | Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| adamexine | mucolytic molecule in which cyclohexyl ring of bromhexine is replaced with adamantane | |
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| cromoglicic acid | Protein S100-P (Organism: Homo sapiens, class: Unclassified, accessions: P25815, gene: S100P, swissprot: S100P_HUMAN) G-protein coupled receptor 35 (Organism: Mus musculus, class: GPCR, accessions: Q9ES90, gene: Gpr35, swissprot: GPR35_MOUSE) G protein-coupled receptor GPR35 (Organism: Rattus norvegicus, class: GPCR, accessions: Q33BM1, gene: Gpr35, swissprot: Q33BM1_RAT) G-protein coupled receptor 35 (Organism: Homo sapiens, class: GPCR, accessions: Q9HC97, gene: GPR35, swissprot: GPR35_HUMAN) | A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. | Decreased Histamine Release (Code: N0000175628) Mast Cell Stabilizer (Code: N0000175630) Anti-Asthmatic Agents (Code: D018927) Respiratory System Agents (Code: D019141) anti-asthmatic drug (Code: CHEBI:49167) | 1982-05-28 FDA | |
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| tartrazine | An anionic, hydrophilic azo dye with an orange-yellow color used in fabrics, foods and cosmetics, and as a biological stain. | Coloring Agents (Code: D004396) Food Additives (Code: D005503) Food Coloring Agents (Code: D005505) histological dye (Code: CHEBI:77178) food colouring (Code: CHEBI:77182) | |
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| lomerizine | Voltage-dependent N-type calcium channel subunit alpha-1B (Organism: Homo sapiens, class: Ion channel, accessions: Q00975, gene: CACNA1B, swissprot: CAC1B_HUMAN) | used to treat migraines | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| ruboxistaurin | Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Protein kinase C theta type (Organism: Homo sapiens, class: Kinase, accessions: Q04759, gene: PRKCQ, swissprot: KPCT_HUMAN) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) Cyclin-dependent kinase-like 5 (Organism: Homo sapiens, class: Kinase, accessions: O76039, gene: CDKL5, swissprot: CDKL5_HUMAN) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) Serine/threonine-protein kinase pim-3 (Organism: Homo sapiens, class: Kinase, accessions: Q86V86, gene: PIM3, swissprot: PIM3_HUMAN) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) Protein kinase C iota type (Organism: Homo sapiens, class: Kinase, accessions: P41743, gene: PRKCI, swissprot: KPCI_HUMAN) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) Serine/threonine-protein kinase ICK (Organism: Homo sapiens, class: Kinase, accessions: Q9UPZ9, gene: ICK, swissprot: ICK_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) cAMP-dependent protein kinase catalytic subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P17612, gene: PRKACA, swissprot: KAPCA_HUMAN) Mitogen-activated protein kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q8TD08, gene: MAPK15, swissprot: MK15_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) Serine/threonine-protein kinase Sgk3 (Organism: Homo sapiens, class: Kinase, accessions: Q96BR1, gene: SGK3, swissprot: SGK3_HUMAN) Protein kinase C gamma type (Organism: Homo sapiens, class: Kinase, accessions: P05129, gene: PRKCG, swissprot: KPCG_HUMAN) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: Q13555, gene: CAMK2G, swissprot: KCC2G_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) Serine/threonine-protein kinase MARK2 (Organism: Homo sapiens, class: Kinase, accessions: Q7KZI7, gene: MARK2, swissprot: MARK2_HUMAN) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) Serine/threonine-protein kinase pim-1 (Organism: Homo sapiens, class: Kinase, accessions: P11309, gene: PIM1, swissprot: PIM1_HUMAN) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Ribosomal protein S6 kinase alpha-3 (Organism: Homo sapiens, class: Kinase, accessions: P51812, gene: RPS6KA3, swissprot: KS6A3_HUMAN) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) Serine/threonine-protein kinase pim-2 (Organism: Homo sapiens, class: Kinase, accessions: Q9P1W9, gene: PIM2, swissprot: PIM2_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) Death-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UIK4, gene: DAPK2, swissprot: DAPK2_HUMAN) Serine/threonine-protein kinase 3 (Organism: Mus musculus, class: Kinase, accessions: Q9JI10, gene: Stk3, swissprot: STK3_MOUSE) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) RAC-gamma serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9Y243, gene: AKT3, swissprot: AKT3_HUMAN) RAC-beta serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31751, gene: AKT2, swissprot: AKT2_HUMAN) Serine/threonine-protein kinase STK11 (Organism: Homo sapiens, class: Kinase, accessions: Q15831, gene: STK11, swissprot: STK11_HUMAN) Rhodopsin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q15835, gene: GRK1, swissprot: RK_HUMAN) CaM kinase II (Organism: Homo sapiens, class: Kinase, accessions: Q13554|Q13555|Q13557|Q9UQM7, gene: CAMK2A|CAMK2B|CAMK2D|CAMK2G, swissprot: KCC2A_HUMAN|KCC2B_HUMAN|KCC2D_HUMAN|KCC2G_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Serine/threonine-protein kinase LATS2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRM7, gene: LATS2, swissprot: LATS2_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Organism: Homo sapiens, class: Kinase, accessions: Q9Y463, gene: DYRK1B, swissprot: DYR1B_HUMAN) Serine/threonine-protein kinase PRP4 homolog (Organism: Homo sapiens, class: Kinase, accessions: Q13523, gene: PRPF4B, swissprot: PRP4B_HUMAN) Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Organism: Homo sapiens, class: Kinase, accessions: O60331, gene: PIP5K1C, swissprot: PI51C_HUMAN) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Death-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53355, gene: DAPK1, swissprot: DAPK1_HUMAN) Protein kinase C delta type (Organism: Homo sapiens, class: Kinase, accessions: Q05655, gene: PRKCD, swissprot: KPCD_HUMAN) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Serine/threonine-protein kinase LATS1 (Organism: Homo sapiens, class: Kinase, accessions: O95835, gene: LATS1, swissprot: LATS1_HUMAN) Protein kinase C (PKC) (Organism: Rattus norvegicus, class: Kinase, accessions: P05696|P09215|P09216|P09217|P63319|P68403|Q64617|Q9WTQ0, gene: Prkca|Prkcb|Prkcd|Prkce|Prkcg|Prkch|Prkcq|Prkcz, swissprot: KPCA_RAT|KPCB_RAT|KPCD_RAT|KPCE_RAT|KPCG_RAT|KPCL_RAT|KPCT_RAT|KPCZ_RAT) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Organism: Homo sapiens, class: Kinase, accessions: P78356, gene: PIP4K2B, swissprot: PI42B_HUMAN) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) Serine/threonine-protein kinase D2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZL6, gene: PRKD2, swissprot: KPCD2_HUMAN) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) SRSF protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P78362, gene: SRPK2, swissprot: SRPK2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) Serine/threonine-protein kinase tousled-like 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UKI8, gene: TLK1, swissprot: TLK1_HUMAN) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) Dual specificity mitogen-activated protein kinase kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: P52564, gene: MAP2K6, swissprot: MP2K6_HUMAN) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit delta (Organism: Homo sapiens, class: Kinase, accessions: Q13557, gene: CAMK2D, swissprot: KCC2D_HUMAN) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) cGMP-dependent protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13237, gene: PRKG2, swissprot: KGP2_HUMAN) cAMP-dependent protein kinase catalytic subunit beta (Organism: Homo sapiens, class: Kinase, accessions: P22694, gene: PRKACB, swissprot: KAPCB_HUMAN) Protein kinase C eta type (Organism: Homo sapiens, class: Kinase, accessions: P24723, gene: PRKCH, swissprot: KPCL_HUMAN) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Protein kinase C beta type (Organism: Homo sapiens, class: Kinase, accessions: P05771, gene: PRKCB, swissprot: KPCB_HUMAN) Protein kinase C alpha type (Organism: Homo sapiens, class: Kinase, accessions: P17252, gene: PRKCA, swissprot: KPCA_HUMAN) | inhibits protein kinase C beta | Enzyme Inhibitors (Code: D004791) | 1UU3 2J2I |
|
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| clinofibrate | None | |
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| ivabradine | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: O60741, gene: HCN1, swissprot: HCN1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UL51, gene: HCN2, swissprot: HCN2_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9P1Z3, gene: HCN3, swissprot: HCN3_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Organism: Mus musculus, class: Ion channel, accessions: O88703, gene: Hcn2, swissprot: HCN2_MOUSE) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Organism: Mus musculus, class: Ion channel, accessions: O88704, gene: Hcn1, swissprot: HCN1_MOUSE) | Ivabradine is a pure heart rate lowering agent, acting by selective and specific inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarisation in the sinus node and regulates heart rate. The cardiac effects are specific to the sinus node with no effect on intra-atrial, atrioventricular or intraventricular conduction times, nor on myocardial contractility or ventricular repolarisation. | Cardiovascular Agents (Code: D002317) Hyperpolarization-activated Cyclic Nucleotide-gated Channel Blocker (Code: N0000191544) Hyperpolarization-activated Cyclic Nucleotide-gated Channel Antagonists (Code: N0000191546) cardiotonic drug (Code: CHEBI:38147) | 2015-04-15 FDA 2005-10-25 EMA | |
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| diethylaminoethoxyhexestrol | None | |
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| simfibrate | None | |
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| colforsin daropate | Adenylate cyclase type 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q08828, gene: ADCY1, swissprot: ADCY1_HUMAN) Solute carrier family 2, facilitated glucose transporter member 1 (Organism: Homo sapiens, class: Transporter, accessions: P11166, gene: SLC2A1, swissprot: GTR1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Adenylate cyclase type 1 (Organism: Bos taurus, class: Unclassified, accessions: P19754, gene: ADCY1, swissprot: ADCY1_BOVIN) | Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland. | Adjuvants, Immunologic (Code: D000276) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Immunologic Factors (Code: D007155) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) | |
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| bucladesine | A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed) | vasodilator agent (Code: CHEBI:35620) cardiotonic drug (Code: CHEBI:38147) | |
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| ebastine | D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | non-sedating second generation antihistamine which is used for allergic disorders | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1990-01-01 YEAR INTRODUCED | |
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| nefazodone | 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) | an antidepressant for oral administration with a chemical structure unrelated to selective serotonin reuptake inhibitors, tricyclics, tetracyclics, or monoamine oxidase inhibitors (MAOI), inhibits neuronal uptake of serotonin and norepinephrine | Serotonin Reuptake Inhibitor (Code: N0000175696) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) antidepressant (Code: CHEBI:35469) serotonergic antagonist (Code: CHEBI:48279) serotonin uptake inhibitor (Code: CHEBI:50949) alpha-adrenergic antagonist (Code: CHEBI:37890) analgesic (Code: CHEBI:35480) | 1994-12-22 FDA | |
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| troxerutin | used in treatment of venous disorders; structure; venoruton & oxerutin is a mixture of hydroxyethyl rutinosides | Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | |
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| dicloxacillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) cGMP-dependent 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O00408, gene: PDE2A, swissprot: PDE2A_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Penicillin-binding protein (Organism: Staphylococcus aureus, class: Enzyme, accessions: P72355|Q53707|Q53725|Q53729|Q9XDB3, gene: PBP2|mecA|pbp4|pbpA|pbpF, swissprot: P72355_STAAU|Q53707_STAAU|Q53725_STAAU|Q53729_STAAU|Q9XDB3_STAAU) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) | One of the PENICILLINS which is resistant to PENICILLINASE. | Penicillin-class Antibacterial (Code: N0000175497) Penicillins (Code: N0000011281) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1968-04-22 FDA | |
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| docarpamine | a dopamine prodrug; RN given refers to (S)-isomer; structure given in first source | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | |
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| enoxolone | Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Homo sapiens, class: Enzyme, accessions: P28845, gene: HSD11B1, swissprot: DHI1_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 2 (Organism: Rattus norvegicus, class: Enzyme, accessions: P50233, gene: Hsd11b2, swissprot: DHI2_RAT) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P16232, gene: Hsd11b1, swissprot: DHI1_RAT) Glycogen phosphorylase, muscle form (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P00489, gene: PYGM, swissprot: PYGM_RABIT) Aldo-keto reductase family 1 member B10 (Organism: Homo sapiens, class: Enzyme, accessions: O60218, gene: AKR1B10, swissprot: AK1BA_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Mus musculus, class: Enzyme, accessions: P50172, gene: Hsd11b1, swissprot: DHI1_MOUSE) Corticosteroid 11-beta-dehydrogenase isozyme 2 (Organism: Homo sapiens, class: Enzyme, accessions: P80365, gene: HSD11B2, swissprot: DHI2_HUMAN) Protein-tyrosine phosphatase 1C (Organism: Homo sapiens, class: Enzyme, accessions: P29350, gene: PTPN6, swissprot: PTN6_HUMAN) Tyrosine-protein phosphatase non-receptor type 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q06124, gene: PTPN11, swissprot: PTN11_HUMAN) Protein kinase C eta type (Organism: Homo sapiens, class: Kinase, accessions: P24723, gene: PRKCH, swissprot: KPCL_HUMAN) | An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. | Anti-Inflammatory Agents (Code: D000893) immunomodulator (Code: CHEBI:50846) | 2W4Q 4PV5 5C71 |
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| cefmetazole | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1989-12-11 FDA | 4KOS |
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| ebrotidine | Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) | an H2-receptor antagonist and gastric mucosa protector | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H2 Antagonists (Code: D006635) Neurotransmitter Agents (Code: D018377) | |
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| maraviroc | Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) C-C chemokine receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P51681, gene: CCR5, swissprot: CCR5_HUMAN) C-C chemokine receptor type 5 (Organism: Macaca mulatta, class: GPCR, accessions: P61813, gene: CCR5, swissprot: CCR5_MACMU) | Maraviroc is a member of a therapeutic class called CCR5 co-receptor antagonists. Maraviroc selectively binds to the human chemokine receptor CCR5 present on the cell membrane, preventing the interaction of HIV-1 gp120 and CCR5 necessary for CCR5-tropic HIV-1 to enter cells. CXCR4-tropic and dual-tropic HIV-1 entry is not inhibited by maraviroc. | CCR5 Co-receptor Antagonist (Code: N0000175572) Chemokine Co-receptor 5 Antagonists (Code: N0000175445) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) CCR5 Receptor Antagonists (Code: D065100) antiviral drug (Code: CHEBI:36044) HIV fusion inhibitor (Code: CHEBI:59886) | 2007-08-06 FDA | 4MBS |
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| terfenadine | Potassium voltage-gated channel subfamily H member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O95259, gene: KCNH1, swissprot: KCNH1_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) C-C chemokine receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P51681, gene: CCR5, swissprot: CCR5_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Heat shock protein HSP 90-alpha (Organism: Homo sapiens, class: Cytosolic other, accessions: P07900, gene: HSP90AA1, swissprot: HS90A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Transcriptional activator protein luxR (Organism: Aliivibrio fischeri, class: Unclassified, accessions: P12746, gene: luxR, swissprot: LUXR_ALIFS) Cytochrome P450 2J2 (Organism: Homo sapiens, class: Enzyme, accessions: P51589, gene: CYP2J2, swissprot: CP2J2_HUMAN) Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) | A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME. | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) | None FDA | |
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| dexamethasone phosphate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1959-09-02 FDA | 3TC5 |
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| methylprednisolone aceponate | None | Anti-Inflammatory Agents (Code: D000893) | |
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| clofazimine | Uncharacterized oxidoreductase CzcO-like (Organism: Geobacillus kaustophilus (strain HTA426), class: Enzyme, accessions: Q5L2G3, gene: None, swissprot: CZCO_GEOKA) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) | A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619) | Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Leprostatic Agents (Code: D007917) leprostatic drug (Code: CHEBI:35816) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) dye (Code: CHEBI:37958) | 1986-12-15 FDA | |
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| carbetocin | Oxytocin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30559, gene: OXTR, swissprot: OXYR_HUMAN) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) | carbetocin selectively binds to oxytocin receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the tone of the uterus musculature | Delayed-Action Preparations (Code: D003692) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) oxytocic (Code: CHEBI:36063) | 2007-11-05 UK Medicines and Healthcare Products Regulatory Agency (MHRA) | |
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| leucovorin | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) | The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS. | Folate Analog (Code: N0000178369) Folic Acid (Code: N0000007151) Antidotes (Code: D000931) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Analogs/Derivatives (Code: N0000175452) Vitamins (Code: D014815) Protective Agents (Code: D020011) Vitamin B Complex (Code: D014803) | 1952-06-20 FDA | 1DFO 1EQB 1JOL 1JOM 1KL2 1PJ7 1QD1 1VRQ 1WOP 1XZQ 2BLN 2VMY 3GEE 3GEH 3SD3 3SUH 3UWL 4GTA 4LVV 4LXQ 4LXT 4LXU 4LXX 4OYT 4XCZ 4XD0 4XD1 5ES7 5UIK 5UIM 5UIN 5VYQ 5VYT |
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| ximelagatran | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Vitamin K-dependent protein C (Organism: Homo sapiens, class: Enzyme, accessions: P04070, gene: PROC, swissprot: PROC_HUMAN) Tissue-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00750, gene: PLAT, swissprot: TPA_HUMAN) Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) Coagulation factor VII (Organism: Homo sapiens, class: Enzyme, accessions: P08709, gene: F7, swissprot: FA7_HUMAN) Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) Coagulation factor XI (Organism: Homo sapiens, class: Enzyme, accessions: P03951, gene: F11, swissprot: FA11_HUMAN) Cationic trypsin (Organism: Bos taurus, class: Enzyme, accessions: P00760, gene: None, swissprot: TRY1_BOVIN) | None | Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) prodrug (Code: CHEBI:50266) | 2004-01-01 YEAR INTRODUCED | |
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| raloxifene | Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Interleukin-6 (Organism: Homo sapiens, class: Cytokine, accessions: P05231, gene: IL6, swissprot: IL6_HUMAN) G-protein coupled estrogen receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q99527, gene: GPER1, swissprot: GPER1_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Phospholipase D2 (Organism: Homo sapiens, class: Enzyme, accessions: O14939, gene: PLD2, swissprot: PLD2_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211|Q62986, gene: Esr1|Esr2, swissprot: ESR1_RAT|ESR2_RAT) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211, gene: Esr1, swissprot: ESR1_RAT) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Phospholipase D1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13393, gene: PLD1, swissprot: PLD1_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Estrogen receptor beta (Organism: Rattus norvegicus, class: Transcription factor, accessions: Q62986, gene: Esr2, swissprot: ESR2_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue. | Estrogen Agonist/Antagonist (Code: N0000175826) Bone Density Conservation Agents (Code: D050071) Estrogen Antagonists (Code: D004965) Estrogen Receptor Modulators (Code: D020847) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Selective Estrogen Receptor Modulators (Code: D020845) bone density conservation agent (Code: CHEBI:50646) estrogen receptor modulator (Code: CHEBI:50739) estrogen antagonist (Code: CHEBI:50837) | 1997-12-09 FDA | 1ERR 1QKN 2JFA 2QXS 2Y05 |
|
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| prednisolamate | None | |
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| mitopodozide | an ethylhydrazide derivative of podophyllic acid; RN given refers to cpd without isomeric designation | Antineoplastic Agents (Code: D000970) | |
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| methylprednisolone succinate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Central Nervous System Agents (Code: D002491) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | 1959-05-18 FDA | |
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| sildenafil | cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Organism: Homo sapiens, class: Enzyme, accessions: P16499, gene: PDE6A, swissprot: PDE6A_HUMAN) Solute carrier organic anion transporter family member 1B3 (Organism: Homo sapiens, class: Transporter, accessions: Q9NPD5, gene: SLCO1B3, swissprot: SO1B3_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: O54735, gene: Pde5a, swissprot: PDE5A_RAT) High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Organism: Homo sapiens, class: Enzyme, accessions: Q13946, gene: PDE7A, swissprot: PDE7A_HUMAN) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Organism: Homo sapiens, class: Enzyme, accessions: O76083, gene: PDE9A, swissprot: PDE9A_HUMAN) Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Uncharacterized protein (Organism: Bos taurus, class: Enzyme, accessions: E1BN64, gene: PDE3B, swissprot: E1BN64_BOVIN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Canis familiaris, class: Enzyme, accessions: O77746, gene: PDE5A, swissprot: PDE5A_CANFA) Phosphodiesterase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q01066|Q63421|Q9EPR9, gene: Pde1a|Pde1b|Pde1c, swissprot: PDE1B_RAT|PDE1C_RAT|Q9EPR9_RAT) cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Organism: Homo sapiens, class: Enzyme, accessions: Q08499, gene: PDE4D, swissprot: PDE4D_HUMAN) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) Indoleamine 2,3-dioxygenase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q8R0V5, gene: Ido2, swissprot: I23O2_MOUSE) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Organism: Homo sapiens, class: Enzyme, accessions: P51160, gene: PDE6C, swissprot: PDE6C_HUMAN) Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Organism: Bos taurus, class: Enzyme, accessions: P11541, gene: PDE6A, swissprot: PDE6A_BOVIN) Phosphodiesterase 1 (Organism: Bos taurus, class: Enzyme, accessions: P14100|Q01061, gene: PDE1A|PDE1B, swissprot: PDE1A_BOVIN|PDE1B_BOVIN) Phosphodiesterase 6 (Organism: Bos taurus, class: Enzyme, accessions: P04972|P11541|P16586|P22571|P23439|Q95142, gene: PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H, swissprot: CNCG_BOVIN|CNRG_BOVIN|PDE6A_BOVIN|PDE6B_BOVIN|PDE6C_BOVIN|PDE6D_BOVIN) Phosphodiesterase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P54750|Q01064|Q14123, gene: PDE1A|PDE1B|PDE1C, swissprot: PDE1A_HUMAN|PDE1B_HUMAN|PDE1C_HUMAN) Phosphodiesterase 2A (Organism: Bos taurus, class: Unclassified, accessions: P14099, gene: PDE2A, swissprot: PDE2A_BOVIN) Phosphodiesterase 4 (Organism: Rattus norvegicus, class: Enzyme, accessions: P14270|P14644|P14646|P54748, gene: Pde4a|Pde4b|Pde4c|Pde4d, swissprot: PDE4A_RAT|PDE4B_RAT|PDE4C_RAT|PDE4D_RAT) Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Organism: Bos taurus, class: Enzyme, accessions: P16586, gene: PDE6C, swissprot: PDE6C_BOVIN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Bos taurus, class: Enzyme, accessions: Q28156, gene: PDE5A, swissprot: PDE5A_BOVIN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCR9, gene: PDE11A, swissprot: PDE11_HUMAN) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y233, gene: PDE10A, swissprot: PDE10_HUMAN) High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Organism: Homo sapiens, class: Enzyme, accessions: O60658, gene: PDE8A, swissprot: PDE8A_HUMAN) cGMP-dependent 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O00408, gene: PDE2A, swissprot: PDE2A_HUMAN) | A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION. | Phosphodiesterase 5 Inhibitor (Code: N0000175599) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase 5 Inhibitors (Code: D058986) Phosphodiesterase Inhibitors (Code: D010726) Urological Agents (Code: D064804) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) | 1998-03-27 FDA | 1TBF 1UDT 1XOS 2H42 3JWQ |
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| tibezonium | None | |
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| rilmazafone | None | Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) | |
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| picloxydine | None | |
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| ertapenem | Penicillin-binding protein 2 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q9X6V3, gene: pbpA, swissprot: Q9X6V3_PSEAI) Penicillin-binding protein 4 (Organism: Staphylococcus aureus, class: Enzyme, accessions: Q5D1E9, gene: None, swissprot: Q5D1E9_STAAU) D-ala-D-ala-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase family protein; Penicillin-binding protein 5 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: Q9X6V7, gene: dacA, swissprot: Q9X6V7_PSEAI) Penicillin-binding protein 1 (Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18), class: Enzyme, accessions: A1KS91, gene: ponA, swissprot: A1KS91_NEIMF) D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6 (Organism: Yersinia pestis, class: Enzyme, accessions: Q7CHG0, gene: dacC, swissprot: Q7CHG0_YERPE) Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) D-alanyl-D-alanine carboxypeptidase DacB (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P24228, gene: dacB, swissprot: DACB_ECOLI) | Ertapenem has in vitro activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. | Carbapenems (Code: N0000011294) Penem Antibacterial (Code: N0000175496) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 2002-04-18 EMA 2001-11-21 FDA | |
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| fluspirilene | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) Nociceptin receptor (Organism: Homo sapiens, class: GPCR, accessions: P41146, gene: OPRL1, swissprot: OPRX_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | A long-acting injectable antipsychotic agent used for chronic schizophrenia. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| gallopamil | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring. | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| netilmicin | Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. | Aminoglycoside Antibacterial (Code: N0000175477) Aminoglycosides (Code: N0000007853) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1983-02-28 FDA | |
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| hydrocortamate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | immunosuppressive agent (Code: CHEBI:35705) anti-inflammatory drug (Code: CHEBI:35472) | 1956-10-15 FDA | |
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| pipotiazine palmitate | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | |
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| dexamethasone valerate | Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | None | |
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| loperamide | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Glutamate receptor ionotropic, NMDA 2D (Organism: Homo sapiens, class: Ion channel, accessions: O15399, gene: GRIN2D, swissprot: NMDE4_HUMAN) Glutamate receptor ionotropic, NMDA 2C (Organism: Homo sapiens, class: Ion channel, accessions: Q14957, gene: GRIN2C, swissprot: NMDE3_HUMAN) Glutamate receptor ionotropic, NMDA 2B (Organism: Homo sapiens, class: Ion channel, accessions: Q13224, gene: GRIN2B, swissprot: NMDE2_HUMAN) Somatostatin receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P35346, gene: SSTR5, swissprot: SSR5_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Calmodulin (Organism: Homo sapiens, class: Cytosolic other, accessions: P62158, gene: CALM1, swissprot: CALM_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Organism: Homo sapiens, class: Ion channel, accessions: O00555, gene: CACNA1A, swissprot: CAC1A_HUMAN) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Glutamate receptor ionotropic, NMDA 2A (Organism: Homo sapiens, class: Ion channel, accessions: Q12879, gene: GRIN2A, swissprot: NMDE1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. | Opioid Agonist (Code: N0000175690) Opioid Agonists (Code: N0000000174) Antidiarrheals (Code: D000930) Gastrointestinal Agents (Code: D005765) mu-opioid receptor agonist (Code: CHEBI:55322) antidiarrhoeal drug (Code: CHEBI:55323) | 1976-12-28 FDA | |
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| betamethasone valerate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | Betamethasone valerate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1967-09-02 FDA | |
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| temocapril | Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1994-01-01 YEAR INTRODUCED | |
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| meclocycline | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | None FDA | |
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| feclobuzone | None | |
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| Streptomycin B | None | |
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| pralatrexate | Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) | Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase. It is also a competitive inhibitor for polyglutamylation by the enzyme folylpolyglutamyl synthetase. This inhibition results in the depletion of thymidine and other biological molecules the synthesis of which depends on single carbon transfer. | Folate Analog Metabolic Inhibitor (Code: N0000175584) antineoplastic agent (Code: CHEBI:35610) | 2009-09-24 FDA | |
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| almitrine | A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep. | Respiratory System Agents (Code: D019141) central nervous system stimulant (Code: CHEBI:35337) | |
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| dextrothyroxine | Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) Thyroid hormone receptor beta (Organism: Rattus norvegicus, class: Transcription factor, accessions: P18113, gene: Thrb, swissprot: THB_RAT) Thyroid hormone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827|P10828, gene: THRA|THRB, swissprot: THA_HUMAN|THB_HUMAN) | The dextrorotary isomer of the synthetic THYROXINE. | 1967-04-14 FDA | |
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| triamcinolone diacetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | lysyl oxidase antagonist; Polcortolon may also refers to triamcinolone | Enzyme Inhibitors (Code: D004791) | 1959-03-12 FDA | |
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| tribenoside | anti-inflammatory agent used in edema of extremities, varicose veins & phlebitis; minor descriptor (75-86); on-line & INDEX MEDICUS search GLYCOSIDES (75-86); RN given refers to parent cpd without isomeric designation | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| dihydroemetine | was MH 1991-94 (see under EMETINE 1976-90); use EMETINE to search DEHYDROEMETINE 1976-94; amebicide, derivative of emetine | |
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| lymecycline | A semisynthetic antibiotic related to TETRACYCLINE. It is more readily absorbed than TETRACYCLINE and can be used in lower doses. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antiprotozoal drug (Code: CHEBI:35820) antibacterial drug (Code: CHEBI:36047) | |
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| chlortetracycline | Major prion protein (Organism: Homo sapiens, class: Surface antigen, accessions: P04156, gene: PRNP, swissprot: PRIO_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Protein-arginine deiminase type-4 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UM07, gene: PADI4, swissprot: PADI4_HUMAN) | A TETRACYCLINE with a 7-chloro substitution. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) antiprotozoal drug (Code: CHEBI:35820) fluorescent probe (Code: CHEBI:39442) antibacterial drug (Code: CHEBI:36047) | 1950-01-23 FDA | 2FJ1 2TCT 2Y6R 3EGZ 4V2G 5TUI |
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| clobetasone butyrate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | None PMDA | |
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| mosapramine | None | None PMDA | |
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| cefteram | None | |
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| stallimycin | DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372|Q92731, gene: ESR1|ESR2, swissprot: ESR1_HUMAN|ESR2_HUMAN) GTPase HRas (Organism: Homo sapiens, class: Cytosolic other, accessions: P01112, gene: HRAS, swissprot: RASH_HUMAN) | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 159D 1JTL 1JUX 1K2Z 216D 217D 267D 2DND 304D 305D 306D 378D |
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| nicardipine | Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Malate dehydrogenase cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P40925, gene: MDH1, swissprot: MDHC_HUMAN) Equilibrative nucleoside transporter 1 (Organism: Rattus norvegicus, class: Transporter, accessions: O54698, gene: Slc29a1, swissprot: S29A1_RAT) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Adenosine receptor A3 (Organism: Rattus norvegicus, class: GPCR, accessions: P28647, gene: Adora3, swissprot: AA3R_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) Voltage-gated L-type calcium channel (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002|P27732|Q02485, gene: Cacna1c|Cacna1d|Cacna1s, swissprot: CAC1C_RAT|CAC1D_RAT|CAC1S_RAT) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) Potassium voltage-gated channel subfamily A member 4 (Organism: Rattus norvegicus, class: Unclassified, accessions: P15385, gene: Kcna4, swissprot: KCNA4_RAT) | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. | Calcium Channel Antagonists (Code: N0000000069) Dihydropyridine Calcium Channel Blocker (Code: N0000175421) Dihydropyridines (Code: N0000007556) Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) Vasodilator Agents (Code: D014665) | 1988-12-21 FDA | |
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| (S)-nicardipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | S-enantiomer of nicardipine is a calcium entry blocker (slow channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations | |
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| emetine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Putative hydrolase RBBP9 (Organism: Homo sapiens, class: Enzyme, accessions: O75884, gene: RBBP9, swissprot: RBBP9_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS. | Amebicides (Code: D000563) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Autonomic Agents (Code: D001337) Cathartics (Code: D002400) Central Nervous System Agents (Code: D002491) Emetics (Code: D004639) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Peripheral Nervous System Agents (Code: D018373) Protein Synthesis Inhibitors (Code: D011500) antiprotozoal drug (Code: CHEBI:35820) | |
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| clocapramine | None | |
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| pranlukast | Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) Cysteinyl leukotriene receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9NS75, gene: CYSLTR2, swissprot: CLTR2_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Cysteinyl leukotriene receptor 1 (Organism: Cavia porcellus, class: GPCR, accessions: Q2NNR5, gene: CYSLTR1, swissprot: CLTR1_CAVPO) Uracil nucleotide/cysteinyl leukotriene receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13304, gene: GPR17, swissprot: GPR17_HUMAN) | SRS-A antagonist; leukotriene D4 receptor antagonist | Anti-Asthmatic Agents (Code: D018927) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Leukotriene Antagonists (Code: D020024) Respiratory System Agents (Code: D019141) | 2007-03-15 PMDA | |
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| pheniodol sodium | None | |
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| talampicillin | An ester of AMPICILLIN which is readily hydrolyzed on absorption to release ampicillin. It is well absorbed from the gastrointestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) prodrug (Code: CHEBI:50266) | |
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| rosuvastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) Phosphodiesterase 6D (Organism: Homo sapiens, class: Enzyme, accessions: O43924, gene: PDE6D, swissprot: PDE6D_HUMAN) | A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES. | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) antilipemic drug (Code: CHEBI:35679) anti-inflammatory agent (Code: CHEBI:67079) cardioprotective agent (Code: CHEBI:77307) | 2003-08-12 FDA | |
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| cefepime | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | None | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1996-01-18 FDA | |
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| amrubicin | ; a 9-amino-anthracycline antibiotic | Antineoplastic Agents (Code: D000970) | |
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| bekanamycin | 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Organism: Escherichia coli, class: Enzyme, accessions: C3TDZ2, gene: fabH, swissprot: C3TDZ2_ECOLX) | kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 2QIR 5U1E |
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| otilonium bromide | None | |
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| uridine triphosphate | P2Y purinoceptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P41231, gene: P2RY2, swissprot: P2RY2_HUMAN) P2Y purinoceptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P51582, gene: P2RY4, swissprot: P2RY4_HUMAN) P2Y purinoceptor 6 (Organism: Homo sapiens, class: GPCR, accessions: Q15077, gene: P2RY6, swissprot: P2RY6_HUMAN) P2Y purinoceptor 11 (Organism: Homo sapiens, class: GPCR, accessions: Q96G91, gene: P2RY11, swissprot: P2Y11_HUMAN) P2X purinoceptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P56373, gene: P2RX3, swissprot: P2RX3_HUMAN) P2Y purinoceptor 4 (Organism: Rattus norvegicus, class: Unclassified, accessions: O35811, gene: P2ry4, swissprot: P2RY4_RAT) | Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. | 1GX6 1NB6 1R8C 1R9S 1TWF 1UEI 1V34 2B51 2B56 2BNF 2E9Z 2ICX 2IKF 2IM2 2IM3 2J4L 2JI5 2NVZ 2Q0F 2YU9 3HIY 3HJ1 3MX5 3OH0 3PKY 4AT9 4BLR 4BPW 4E7C 4E80 4EDR 4EP7 4F04 4FH5 4FHP 4FYX 4FYY 4HO6 4HO9 4HOS 4J6X 4JLZ 4JST 4KGZ 4KH1 4LIL 4O8E 4RY5 4ZDJ 4ZDK 5A2Y 5A9A 5IDO 5KAL 5VE7 5VZ8 5VZB 5VZE 5VZH 5W0O 5WU2 5WU3 |
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| nicergoline | An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It may ameliorate cognitive deficits in CEREBROVASCULAR DISORDERS. | Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Neurotransmitter Agents (Code: D018377) Nootropic Agents (Code: D018697) Vasodilator Agents (Code: D014665) | |
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| kanamycin | Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Organism: Escherichia coli, class: Enzyme, accessions: O32553, gene: mphB, swissprot: O32553_ECOLX) 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P0A6R0, gene: fabH, swissprot: FABH_ECOLI) | Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. | Aminoglycoside Antibacterial (Code: N0000175477) Aminoglycosides (Code: N0000007853) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1973-02-13 FDA | 1KNY 1L8T 1M4I 1ND4 2ESI 3KP5 3Q5R 3SG9 3U6T 4DFB 4DFU 4EM0 4FEU 4FEV 4FEW 4FEX 4GKH 4GKI 4OKN 4QC6 4WQL 5IQB 6BFH |
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| fentonium | less effect on eye, heart & gland functions than atropine; proposed for therapy of gastrointestinal ulcers; minor descriptor (78-84); on-line & Index Medicus search ATROPINE DERIVATIVES (78-84); RN given refers to bromide(3(S)-endo)-isomer | |
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| ulobetasol propionate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | used in ointment to treat psoriasis; Ulobetasol cream contains 0.05% 6-fluoroclobetasol 17-propionate | 1990-12-17 FDA | |
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| etiprednol dicloacetate | a soft corticosteroid | |
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| imiclopazine | None | |
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| prednisolone valerate acetate | topical steroid used for skin disease therapy | |
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| hydrocortisone cypionate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1955-05-10 FDA | |
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| fenoxedil | None | |
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| fluclorolone acetonide | synthetic glucocorticoid with anti-inflammatory properties; minor descriptor (75-83); on-line & Index Medicus search PREGNADIENETROLS (75-83); RN given refers to (6alpha,11beta,16alpha)-isomer; structure | |
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| riodoxol | None | |
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| dasatinib | Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Breakpoint cluster region protein (Organism: Homo sapiens, class: Kinase, accessions: P11274, gene: BCR, swissprot: BCR_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tubulin alpha-1A chain (Organism: Rattus norvegicus, class: Structural, accessions: P68370, gene: Tuba1a, swissprot: TBA1A_RAT) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) Serine/threonine-protein kinase mTOR (Organism: Homo sapiens, class: Kinase, accessions: P42345, gene: MTOR, swissprot: MTOR_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Gallus gallus, class: Kinase, accessions: P00523, gene: SRC, swissprot: SRC_CHICK) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Myelin transcription factor 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q01538, gene: MYT1, swissprot: MYT1_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) MAP kinase p38 (Organism: Homo sapiens, class: Kinase, accessions: O15264|P53778|Q15759|Q16539, gene: MAPK11|MAPK12|MAPK13|MAPK14, swissprot: MK11_HUMAN|MK12_HUMAN|MK13_HUMAN|MK14_HUMAN) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) Serine/threonine-protein kinase Nek11 (Organism: Homo sapiens, class: Kinase, accessions: Q8NG66, gene: NEK11, swissprot: NEK11_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Serine/threonine-protein kinase MRCK alpha (Organism: Homo sapiens, class: Kinase, accessions: Q5VT25, gene: CDC42BPA, swissprot: MRCKA_HUMAN) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) Tyrosine-protein kinase Blk (Organism: Mus musculus, class: Kinase, accessions: P16277, gene: Blk, swissprot: BLK_MOUSE) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Chaperone activity of bc1 complex-like, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q8NI60, gene: COQ8A, swissprot: COQ8A_HUMAN) Serine/threonine-protein kinase 25 (Organism: Homo sapiens, class: Kinase, accessions: O00506, gene: STK25, swissprot: STK25_HUMAN) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Proto-oncogene tyrosine-protein kinase LCK (Organism: Mus musculus, class: Kinase, accessions: P06240, gene: Lck, swissprot: LCK_MOUSE) Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Organism: Homo sapiens, class: Kinase, accessions: Q99640, gene: PKMYT1, swissprot: PMYT1_HUMAN) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) Protein-tyrosine kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q13882, gene: PTK6, swissprot: PTK6_HUMAN) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) Serine/threonine-protein kinase Nek2 (Organism: Homo sapiens, class: Kinase, accessions: P51955, gene: NEK2, swissprot: NEK2_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) LIM domain kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53667, gene: LIMK1, swissprot: LIMK1_HUMAN) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) Dual specificity testis-specific protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q15569, gene: TESK1, swissprot: TESK1_HUMAN) Activin receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: Q04771, gene: ACVR1, swissprot: ACVR1_HUMAN) Serine/threonine-protein kinase MRCK gamma (Organism: Homo sapiens, class: Kinase, accessions: Q6DT37, gene: CDC42BPG, swissprot: MRCKG_HUMAN) Serine/threonine-protein kinase MRCK beta (Organism: Homo sapiens, class: Kinase, accessions: Q9Y5S2, gene: CDC42BPB, swissprot: MRCKB_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) Activin receptor type-2B (Organism: Homo sapiens, class: Kinase, accessions: Q13705, gene: ACVR2B, swissprot: AVR2B_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Tyrosine-protein kinase Srms (Organism: Homo sapiens, class: Kinase, accessions: Q9H3Y6, gene: SRMS, swissprot: SRMS_HUMAN) Serine/threonine-protein kinase SIK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2K2, gene: SIK3, swissprot: SIK3_HUMAN) Dual specificity mitogen-activated protein kinase kinase; MEK1/2 (Organism: Homo sapiens, class: Kinase, accessions: P36507|Q02750, gene: MAP2K1|MAP2K2, swissprot: MP2K1_HUMAN|MP2K2_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Wee1-like protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P0C1S8, gene: WEE2, swissprot: WEE2_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Serine/threonine-protein kinase receptor R3 (Organism: Homo sapiens, class: Kinase, accessions: P37023, gene: ACVRL1, swissprot: ACVL1_HUMAN) Activin receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: P36896, gene: ACVR1B, swissprot: ACV1B_HUMAN) Bone morphogenetic protein receptor type-1A (Organism: Homo sapiens, class: Kinase, accessions: P36894, gene: BMPR1A, swissprot: BMR1A_HUMAN) TGF-beta receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: P36897, gene: TGFBR1, swissprot: TGFR1_HUMAN) TGF-beta receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: P37173, gene: TGFBR2, swissprot: TGFR2_HUMAN) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) Activin receptor type-2A (Organism: Homo sapiens, class: Kinase, accessions: P27037, gene: ACVR2A, swissprot: AVR2A_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Ephrin type-B receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29323, gene: EPHB2, swissprot: EPHB2_HUMAN) Mitogen-activated protein kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q15759, gene: MAPK11, swissprot: MK11_HUMAN) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) Serine/threonine-protein kinase VRK2 (Organism: Homo sapiens, class: Kinase, accessions: Q86Y07, gene: VRK2, swissprot: VRK2_HUMAN) LIM domain kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P53671, gene: LIMK2, swissprot: LIMK2_HUMAN) Ephrin type-B receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P54753, gene: EPHB3, swissprot: EPHB3_HUMAN) Tyrosine-protein kinase Tec (Organism: Homo sapiens, class: Kinase, accessions: P42680, gene: TEC, swissprot: TEC_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Serine/threonine-protein kinase NLK (Organism: Homo sapiens, class: Kinase, accessions: Q9UBE8, gene: NLK, swissprot: NLK_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Bcr/Abl fusion protein (Organism: Homo sapiens, class: Kinase, accessions: P00519|P11274, gene: ABL1|BCR, swissprot: ABL1_HUMAN|BCR_HUMAN) | A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2006-06-28 FDA | 2GQG 2Y6O 2ZVA 3G5D 3K54 3LFA 3OCT 3OHT 3QLG 3SXR 4QMS 4XEY 4XLI 5BVW 5H2U 5I9Y 5OWR 5VCV |
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| neltenexine | elastase inhibitor; may be useful for preventing pulmonary emphysema | 2001-10-16 Korean Food and Drug Administration (KFDA) | |
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| estriol succinate | Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Lanosterol 14-alpha demethylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPP9, gene: cyp51, swissprot: CP51_MYCTU) | None | |
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| prednicarbate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1991-09-23 FDA | |
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| vardenafil | cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Organism: Homo sapiens, class: Enzyme, accessions: P54750, gene: PDE1A, swissprot: PDE1A_HUMAN) Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Organism: Homo sapiens, class: Enzyme, accessions: P16499, gene: PDE6A, swissprot: PDE6A_HUMAN) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Organism: Homo sapiens, class: Enzyme, accessions: O76083, gene: PDE9A, swissprot: PDE9A_HUMAN) Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) Phosphodiesterase 1 (Organism: Bos taurus, class: Enzyme, accessions: P14100|Q01061, gene: PDE1A|PDE1B, swissprot: PDE1A_BOVIN|PDE1B_BOVIN) cGMP-dependent 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O00408, gene: PDE2A, swissprot: PDE2A_HUMAN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCR9, gene: PDE11A, swissprot: PDE11_HUMAN) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y233, gene: PDE10A, swissprot: PDE10_HUMAN) | A piperazine derivative, PHOSPHODIESTERASE 5 INHIBITOR and VASODILATOR AGENT that is used as a UROLOGICAL AGENT in the treatment of ERECTILE DYSFUNCTION. | Phosphodiesterase 5 Inhibitor (Code: N0000175599) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Phosphodiesterase 5 Inhibitors (Code: D058986) Phosphodiesterase Inhibitors (Code: D010726) Urological Agents (Code: D064804) Vasodilator Agents (Code: D014665) vasodilator agent (Code: CHEBI:35620) | 2003-08-19 FDA | 1UHO 1XOT 1XP0 3B2R |
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| citicoline | Donor of choline in biosynthesis of choline-containing phosphoglycerides. | Central Nervous System Agents (Code: D002491) Nootropic Agents (Code: D018697) psychotropic drug (Code: CHEBI:35471) neuroprotective agent (Code: CHEBI:63726) | 1JYL 3HL4 4BET 4MVC 4MVD 4ZCS |
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| cefamandole nafate | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) prodrug (Code: CHEBI:50266) antibacterial drug (Code: CHEBI:36047) | 1978-09-27 FDA | |
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| glimepiride | Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | None | Sulfonylurea (Code: N0000175608) Sulfonylurea Compounds (Code: N0000008054) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Hypoglycemic Agents (Code: D007004) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) hypoglycemic agent (Code: CHEBI:35526) | 1995-11-30 FDA | |
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| sulisatin | None | |
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| barnidipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| lidoflazine | Equilibrative nucleoside transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q99808, gene: SLC29A1, swissprot: S29A1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) | Coronary vasodilator with some antiarrhythmic action. | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) | |
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| teicoplanin aglycone | None | 1988-01-01 YEAR INTRODUCED | |
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| cilnidipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) Voltage-dependent N-type calcium channel subunit alpha-1B (Organism: Rattus norvegicus, class: Unclassified, accessions: Q02294, gene: Cacna1b, swissprot: CAC1B_RAT) | has excitatory & inhibitory action on the Ca+ channels in the rabbit basilar artery; structure given in first source; RN given is for (+-) isomer | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) antihypertensive agent (Code: CHEBI:35674) cardiovascular drug (Code: CHEBI:35554) | |
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| bezitramide | None | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| loperamide oxide | None | Antidiarrheals (Code: D000930) Gastrointestinal Agents (Code: D005765) | |
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| aspoxicillin | None | |
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| imatinib | Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Gallus gallus, class: Kinase, accessions: P00523, gene: SRC, swissprot: SRC_CHICK) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Mus musculus, class: Kinase, accessions: P00520, gene: Abl1, swissprot: ABL1_MOUSE) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Organism: Homo sapiens, class: Kinase, accessions: Q8TBX8, gene: PIP4K2C, swissprot: PI42C_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Lysine--tRNA ligase (Organism: Homo sapiens, class: Enzyme, accessions: Q15046, gene: KARS, swissprot: SYK_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Tyrosine-protein kinase ABL (Organism: Homo sapiens, class: Kinase, accessions: P00519|P42684, gene: ABL1|ABL2, swissprot: ABL1_HUMAN|ABL2_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Bcr/Abl fusion protein (Organism: Homo sapiens, class: Kinase, accessions: P00519|P11274, gene: ABL1|BCR, swissprot: ABL1_HUMAN|BCR_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Cyclin-dependent kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q9BWU1, gene: CDK19, swissprot: CDK19_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Platelet-derived growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P09619|P16234, gene: PDGFRA|PDGFRB, swissprot: PGFRA_HUMAN|PGFRB_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) | A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors. | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2001-05-10 FDA | 1IEP 1OPJ 1T46 1XBB 2HYY 2OIQ 2PL0 3FW1 3GVU 3HEC 3K5V 3MS9 3MSS 3OEZ 3PYY 4BKJ 4CSV 4R7I 5MQT |
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| glibenclamide | Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cystic fibrosis transmembrane conductance regulator (Organism: Homo sapiens, class: Ion channel, accessions: P13569, gene: CFTR, swissprot: CFTR_HUMAN) Sulfonylurea receptor 2, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: O60706|Q14654, gene: ABCC9|KCNJ11, swissprot: ABCC9_HUMAN|KCJ11_HUMAN) Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) ATP-sensitive inward rectifier potassium channel 11 (Organism: Mus musculus, class: Unclassified, accessions: Q61743, gene: Kcnj11, swissprot: KCJ11_MOUSE) | An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. | Sulfonylurea (Code: N0000175608) Sulfonylurea Compounds (Code: N0000008054) Hypoglycemic Agents (Code: D007004) anti-arrhythmia drug (Code: CHEBI:38070) hypoglycemic agent (Code: CHEBI:35526) | 1984-05-01 FDA | 4YVP 4YVV 5IFU |
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| fluocinonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | A topical glucocorticoid used in the treatment of ECZEMA. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Allergic Agents (Code: D018926) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1971-06-30 FDA | |
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| carindacillin | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer) | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1972-10-26 FDA | |
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| tiquizium | Muscarinic acetylcholine receptor (Organism: Canis familiaris, class: GPCR, accessions: F1PT23, gene: CHRM1, swissprot: F1PT23_CANFA) Muscarinic acetylcholine receptor (Organism: Canis familiaris, class: GPCR, accessions: F1PWR7, gene: CHRM2, swissprot: F1PWR7_CANFA) Muscarinic acetylcholine receptor (Organism: Canis familiaris, class: GPCR, accessions: F1PGZ2, gene: CHRM3, swissprot: F1PGZ2_CANFA) | antispasmodic; RN refers to bromide (trans)-isomer | |
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| flumetasone pivalate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) antipruritic drug (Code: CHEBI:59683) | None FDA | |
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| nicomorphine | None | Analgesics (Code: D000700) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| mibefradil | Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cation channel sperm-associated protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NEC5, gene: CATSPER1, swissprot: CTSR1_HUMAN) Cation channel sperm-associated protein 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q96P56, gene: CATSPER2, swissprot: CTSR2_HUMAN) Cation channel sperm-associated protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q86XQ3, gene: CATSPER3, swissprot: CTSR3_HUMAN) Cation channel sperm-associated protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q7RTX7, gene: CATSPER4, swissprot: CTSR4_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1I (Organism: Homo sapiens, class: Ion channel, accessions: Q9P0X4, gene: CACNA1I, swissprot: CAC1I_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Voltage-dependent N-type calcium channel subunit alpha-1B (Organism: Homo sapiens, class: Ion channel, accessions: Q00975, gene: CACNA1B, swissprot: CAC1B_HUMAN) Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Organism: Rattus norvegicus, class: Unclassified, accessions: P54282, gene: Cacna1a, swissprot: CAC1A_RAT) Voltage-dependent R-type calcium channel subunit alpha-1E (Organism: Rattus norvegicus, class: Unclassified, accessions: Q07652, gene: Cacna1e, swissprot: CAC1E_RAT) | A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE. | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Vasodilator Agents (Code: D014665) | 1997-08-01 FDA | |
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| orlistat | Monoacylglycerol lipase ABHD6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BV23, gene: ABHD6, swissprot: ABHD6_HUMAN) Pancreatic triacylglycerol lipase (Organism: Homo sapiens, class: Enzyme, accessions: P16233, gene: PNLIP, swissprot: LIPP_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) Monoacylglycerol lipase ABHD12 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N2K0, gene: ABHD12, swissprot: ABD12_HUMAN) Sn1-specific diacylglycerol lipase beta (Organism: Homo sapiens, class: Enzyme, accessions: Q8NCG7, gene: DAGLB, swissprot: DGLB_HUMAN) Sn1-specific diacylglycerol lipase alpha (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y4D2, gene: DAGLA, swissprot: DGLA_HUMAN) Pancreatic triacylglycerol lipase (Organism: Sus scrofa, class: Enzyme, accessions: P00591, gene: PNLIP, swissprot: LIPP_PIG) Abhydrolase domain-containing protein 16A (Organism: Homo sapiens, class: Enzyme, accessions: O95870, gene: ABHD16A, swissprot: ABHGA_HUMAN) Platelet-activating factor acetylhydrolase (Organism: Homo sapiens, class: Enzyme, accessions: Q13093, gene: PLA2G7, swissprot: PAFA_HUMAN) Gastric triacylglycerol lipase (Organism: Homo sapiens, class: Enzyme, accessions: P07098, gene: LIPF, swissprot: LIPG_HUMAN) | isolated from Streptomyces toxytricini; inhibits 3C protease, viral | Intestinal Lipase Inhibitor (Code: N0000175591) Lipase Inhibitors (Code: N0000009916) Anti-Obesity Agents (Code: D019440) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) | 1999-04-23 FDA | |
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| perflexane | None | Contrast Agent for Ultrasound Imaging (Code: N0000175864) Ultrasound Contrast Activity (Code: N0000010259) radioopaque medium (Code: CHEBI:37338) | 2002-05-31 FDA | |
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| betamethasone benzoate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | None FDA | |
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| idarubicin | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA. | Anthracycline Topoisomerase Inhibitor (Code: N0000175414) Anthracyclines (Code: N0000007530) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1990-09-27 FDA | 198D 1D38 1D67 3ARQ 4LB2 |
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| tebipenem pivoxil | an oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae | |
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| moexipril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | None | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 1995-04-19 FDA | |
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| zucapsaicin | Transient receptor potential cation channel subfamily V member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NER1, gene: TRPV1, swissprot: TRPV1_HUMAN) | the cis-isomer of alkyl vanillylamide | |
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| binifibrate | two nicotinic & one clofibiric radical esterified by glycerol moiety | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| clobenoside | None | |
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| halofantrine | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | used in treatment of mild to moderate acute malaria | Antimalarial (Code: N0000175482) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | 1992-07-24 FDA | |
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| tritoqualine | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | |
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| travoprost | Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) | A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. | Prostaglandin Analog (Code: N0000175454) Prostaglandins (Code: N0000007706) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) ophthalmology drug (Code: CHEBI:66981) antiglaucoma drug (Code: CHEBI:39456) antihypertensive agent (Code: CHEBI:35674) prodrug (Code: CHEBI:50266) | 2001-11-27 EMA 2001-03-16 FDA | |
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| fluticasone propionate | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Cytosolic phospholipase A2 (Organism: Homo sapiens, class: Enzyme, accessions: P47712, gene: PLA2G4A, swissprot: PA24A_HUMAN) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) | A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Allergic Agents (Code: D018926) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Dermatologic Agents (Code: D003879) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) anti-allergic agent (Code: CHEBI:50857) anti-asthmatic drug (Code: CHEBI:49167) anti-inflammatory drug (Code: CHEBI:35472) adrenergic agent (Code: CHEBI:37962) dermatologic drug (Code: CHEBI:50177) bronchodilator agent (Code: CHEBI:35523) | 1990-12-14 FDA | |
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| mupirocin | Isoleucine--tRNA ligase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00956, gene: ileS, swissprot: SYI_ECOLI) Isoleucine--tRNA ligase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P41972, gene: ileS, swissprot: SYI1_STAAU) Isoleucine--tRNA ligase, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P41252, gene: IARS, swissprot: SYIC_HUMAN) Isoleucine--tRNA ligase (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: Q99YW3, gene: ileS, swissprot: SYI_STRP1) | A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing. | RNA Synthetase Inhibitor Antibacterial (Code: N0000175515) RNA Synthetase Inhibitors (Code: N0000175516) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) antibacterial drug (Code: CHEBI:36047) | 1987-12-31 FDA | |
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| adefovir dipivoxil | DNA polymerase subunit gamma-1 (Organism: Homo sapiens, class: Enzyme, accessions: P54098, gene: POLG, swissprot: DPOG1_HUMAN) Protein P (Organism: Hepatitis B virus, class: Polyprotein, accessions: Q9IF40, gene: P, swissprot: Q9IF40_HBV) | inhibitor of African swine fever virus | Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175656) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) prodrug (Code: CHEBI:50266) antiviral drug (Code: CHEBI:36044) | 2003-03-06 EMA 2002-09-20 FDA | |
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| fexofenadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier organic anion transporter family member 1A2 (Organism: Homo sapiens, class: Unclassified, accessions: P46721, gene: SLCO1A2, swissprot: SO1A2_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; ; RN refers to HCl | Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) Anti-Allergic Agents (Code: D018926) Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Histamine H1 Antagonists, Non-Sedating (Code: D039563) Neurotransmitter Agents (Code: D018377) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) | 1996-07-25 FDA | |
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| amcinonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) | 1979-10-18 FDA | |
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| dexamethasone dipropionate | None | |
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| betamethasone dipropionate | Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1975-01-29 FDA | |
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| betamethasone acibutate | None | |
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| dipyridamole | cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Organism: Homo sapiens, class: Enzyme, accessions: O95263, gene: PDE8B, swissprot: PDE8B_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) Cyclic AMP-specific phosphodiesterase SSPDE4A1A (Organism: Sus scrofa, class: Enzyme, accessions: O77823, gene: PDE4A, swissprot: O77823_PIG) Protein prune homolog (Organism: Homo sapiens, class: Enzyme, accessions: Q86TP1, gene: PRUNE, swissprot: PRUNE_HUMAN) Equilibrative nucleoside transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q99808, gene: SLC29A1, swissprot: S29A1_HUMAN) Phosphodiesterase 6 (Organism: Homo sapiens, class: Enzyme, accessions: O43924|P16499|P18545|P35913|P51160|Q13956, gene: PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H, swissprot: CNCG_HUMAN|CNRG_HUMAN|PDE6A_HUMAN|PDE6B_HUMAN|PDE6C_HUMAN|PDE6D_HUMAN) cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Organism: Homo sapiens, class: Enzyme, accessions: Q9NP56, gene: PDE7B, swissprot: PDE7B_HUMAN) Phosphodiesterase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q13946|Q9NP56, gene: PDE7A|PDE7B, swissprot: PDE7A_HUMAN|PDE7B_HUMAN) Phosphodiesterase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P54750|Q01064|Q14123, gene: PDE1A|PDE1B|PDE1C, swissprot: PDE1A_HUMAN|PDE1B_HUMAN|PDE1C_HUMAN) cGMP-dependent 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O00408, gene: PDE2A, swissprot: PDE2A_HUMAN) Phosphodiesterase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q13370|Q14432, gene: PDE3A|PDE3B, swissprot: PDE3A_HUMAN|PDE3B_HUMAN) Cyclic nucleotide phosphodiesterase PDE3A (Organism: Sus scrofa, class: Enzyme, accessions: Q9XSW7, gene: None, swissprot: Q9XSW7_PIG) Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCR9, gene: PDE11A, swissprot: PDE11_HUMAN) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y233, gene: PDE10A, swissprot: PDE10_HUMAN) High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Organism: Homo sapiens, class: Enzyme, accessions: O60658, gene: PDE8A, swissprot: PDE8A_HUMAN) ORF 73 (Organism: Human herpesvirus 8, class: Unclassified, accessions: O40947, gene: None, swissprot: O40947_HHV8) Equilibrative nucleoside transporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q7RTT9, gene: SLC29A4, swissprot: S29A4_HUMAN) | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Decreased Platelet Aggregation (Code: N0000008832) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Phosphodiesterase Inhibitors (Code: D010726) Platelet Aggregation Inhibitors (Code: D010975) Vasodilator Agents (Code: D014665) platelet aggregation inhibitor (Code: CHEBI:50427) vasodilator agent (Code: CHEBI:35620) | 1961-12-06 FDA | |
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| clindamycin phosphate | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1972-10-02 FDA | |
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| chlorhexidine | Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) CAAX prenyl protease 2 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: Q03530, gene: RCE1, swissprot: RCE1_YEAST) | A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. | Decreased Cell Wall Integrity (Code: N0000008478) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Cosmetics (Code: D003358) Dermatologic Agents (Code: D003879) Disinfectants (Code: D004202) Mouthwashes (Code: D009067) antiinfective agent (Code: CHEBI:35441) | 1976-09-17 FDA | |
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| benidipine | Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Vasodilator Agents (Code: D014665) | 1991-01-01 YEAR INTRODUCED | |
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| hepronicate | None | |
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| amprenavir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Cathepsin D (Organism: Homo sapiens, class: Enzyme, accessions: P07339, gene: CTSD, swissprot: CATD_HUMAN) | ; RN refers to (3S-(3R*(1S*,2R*)))-isomer; fosamprenavir is a prodrug | Protease Inhibitor (Code: N0000175889) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A4 Inducers (Code: N0000185506) P-Glycoprotein Inducers (Code: N0000191264) Anti-Bacterial Agents (Code: D000900) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antibiotics, Antitubercular (Code: D000904) Antitubercular Agents (Code: D000995) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Protease Inhibitors (Code: D011480) antiviral drug (Code: CHEBI:36044) | 2000-10-20 EMA 1999-04-15 FDA | 1HPV 1T7J 3EKP 3EKV 3EM3 3NU3 3NU4 3NU5 3NU6 3NU9 3NUJ 3NUO 3OXV 3S43 3S45 3SM2 4J5J 4JEC 4RVJ 5KR0 5T8H |
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| tropesin | None | |
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| indocyanine green | A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output. | Diagnostic Dye (Code: N0000175536) Dyes (Code: N0000175533) Coloring Agents (Code: D004396) | 1959-02-09 FDA | |
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| ixabepilone | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) | has antineoplastic activity; epothilone B lactam analogue that induces cell cycle arrest at the G(2)-M phase | Microtubule Inhibition (Code: N0000175085) Microtubule Inhibitor (Code: N0000175592) antineoplastic agent (Code: CHEBI:35610) | 2007-10-16 FDA | |
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| adenosine triphosphate | P2X purinoceptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P49653, gene: P2rx2, swissprot: P2RX2_RAT) P2X purinoceptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P51575, gene: P2RX1, swissprot: P2RX1_HUMAN) P2X purinoceptor 5 (Organism: Rattus norvegicus, class: Unclassified, accessions: P51578, gene: P2rx5, swissprot: P2RX5_RAT) P2X purinoceptor 6 (Organism: Rattus norvegicus, class: Unclassified, accessions: P51579, gene: P2rx6, swissprot: P2RX6_RAT) Transient receptor potential cation channel subfamily M member 4 (Organism: Mus musculus, class: Unclassified, accessions: Q7TN37, gene: Trpm4, swissprot: TRPM4_MOUSE) P2X purinoceptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q99571, gene: P2RX4, swissprot: P2RX4_HUMAN) P2X purinoceptor 4 (Organism: Mus musculus, class: Unclassified, accessions: Q9JJX6, gene: P2rx4, swissprot: P2RX4_MOUSE) P2Y purinoceptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P41231, gene: P2RY2, swissprot: P2RY2_HUMAN) P2Y purinoceptor 13 (Organism: Homo sapiens, class: GPCR, accessions: Q9BPV8, gene: P2RY13, swissprot: P2Y13_HUMAN) Transient receptor potential cation channel subfamily M member 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8TD43, gene: TRPM4, swissprot: TRPM4_HUMAN) P2X purinoceptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P56373, gene: P2RX3, swissprot: P2RX3_HUMAN) Uracil nucleotide/cysteinyl leukotriene receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13304, gene: GPR17, swissprot: GPR17_HUMAN) P2Y purinoceptor 1 (Organism: Meleagris gallopavo, class: GPCR, accessions: P49652, gene: P2RY1, swissprot: P2RY1_MELGA) Endoplasmin (Organism: Canis familiaris, class: Membrane other, accessions: P41148, gene: HSP90B1, swissprot: ENPL_CANFA) Heat shock protein 75 kDa, mitochondrial (Organism: Homo sapiens, class: Unclassified, accessions: Q12931, gene: TRAP1, swissprot: TRAP1_HUMAN) P2Y purinoceptor 11 (Organism: Homo sapiens, class: GPCR, accessions: Q96G91, gene: P2RY11, swissprot: P2Y11_HUMAN) MAP kinase-activated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P49137, gene: MAPKAPK2, swissprot: MAPK2_HUMAN) Adenylate kinase 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P29410, gene: Ak2, swissprot: KAD2_RAT) P2Y purinoceptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P51582, gene: P2RY4, swissprot: P2RY4_HUMAN) P2Y purinoceptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P47900, gene: P2RY1, swissprot: P2RY1_HUMAN) Heat shock cognate 71 kDa protein (Organism: Homo sapiens, class: Unclassified, accessions: P11142, gene: HSPA8, swissprot: HSP7C_HUMAN) Heat shock 70 kDa protein 1A (Organism: Homo sapiens, class: Unclassified, accessions: P0DMV8, gene: HSPA1A, swissprot: HS71A_HUMAN) | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. | nutraceutical (Code: CHEBI:50733) | |
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| oxaflumazine | psychosedative | |
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| difluprednate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 2008-06-23 FDA | |
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| argatroban | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) Prothrombin (Organism: Bos taurus, class: Enzyme, accessions: P00735, gene: F2, swissprot: THRB_BOVIN) Tissue-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00750, gene: PLAT, swissprot: TPA_HUMAN) Cationic trypsin (Organism: Bos taurus, class: Enzyme, accessions: P00760, gene: None, swissprot: TRY1_BOVIN) | None | Anti-coagulant (Code: N0000175980) Direct Thrombin Inhibitor (Code: N0000175518) Thrombin Inhibitors (Code: N0000009963) Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) | 2000-06-30 FDA | 1DWC 1ETR 4HFP 4RN6 |
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| alexidine | Toll-like receptor 9 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q9NR96, gene: TLR9, swissprot: TLR9_HUMAN) | until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd | |
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| clomocycline | None | antibacterial drug (Code: CHEBI:36047) antiprotozoal drug (Code: CHEBI:35820) | |
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| landiolol | Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) | |
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| chlorisondamine | A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications. | Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | |
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| cefuroxime axetil | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1987-12-28 FDA | |
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| pinaverium | None | Autonomic Agents (Code: D001337) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373) | |
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| cefmenoxime | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1987-12-30 FDA | |
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| cefetamet pivoxil | Penicillin-binding protein 1 (Organism: Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18), class: Enzyme, accessions: A1KS91, gene: ponA, swissprot: A1KS91_NEIMF) Penicillin-binding protein 3 (Organism: Bacillus subtilis (strain 168), class: Enzyme, accessions: P42971, gene: pbpC, swissprot: PBPC_BACSU) | None | 1992-01-01 YEAR INTRODUCED | |
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| sobuzoxane | used in treatment of leukemia L1210 | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| flomoxef | None | antibacterial drug (Code: CHEBI:36047) | |
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| acetoxolone | Estradiol 17-beta-dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14061, gene: HSD17B1, swissprot: DHB1_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Homo sapiens, class: Enzyme, accessions: P28845, gene: HSD11B1, swissprot: DHI1_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 2 (Organism: Homo sapiens, class: Enzyme, accessions: P80365, gene: HSD11B2, swissprot: DHI2_HUMAN) Estradiol 17-beta-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P37059, gene: HSD17B2, swissprot: DHB2_HUMAN) | None | |
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| carubicin | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) | A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata. | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) | |
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| cefuzonam | article gives L-105 as synonym, however L 105 is a rifamycin derivative according to Chemline | antibacterial drug (Code: CHEBI:36047) | |
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| telmisartan | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) Type-2 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P50052, gene: AGTR2, swissprot: AGTR2_HUMAN) Type-1A angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095, gene: Agtr1, swissprot: AGTRA_RAT) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | angiotensin II receptor antagonist and antihypertensive agent; structure given in first source | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) antihypertensive agent (Code: CHEBI:35674) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) angiotensin receptor antagonist (Code: CHEBI:61016) | 1998-11-10 FDA | 3VN2 |
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| cefpirome | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1983-01-01 YEAR INTRODUCED | |
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| cynarine | Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) | active principle of the artichoke; functions primarily as a cholagogue and choleretic and also as antilipemic agent | Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) | |
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| cefozopran | None | |
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| probucol | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Arachidonate 15-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P16050, gene: ALOX15, swissprot: LOX15_HUMAN) ATP-binding cassette sub-family A member 1 (Organism: Homo sapiens, class: Transporter, accessions: O95477, gene: ABCA1, swissprot: ABCA1_HUMAN) | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Antioxidants (Code: D000975) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Protective Agents (Code: D020011) anti-inflammatory drug (Code: CHEBI:35472) cardiovascular drug (Code: CHEBI:35554) antilipemic drug (Code: CHEBI:35679) anticholesteremic drug (Code: CHEBI:35821) | 1977-02-01 FDA | |
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| piperacillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Streptokinase A (Organism: Streptococcus pyogenes serotype M1, class: Enzyme, accessions: P10520, gene: ska, swissprot: STRP_STRP1) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1981-12-29 FDA | 3Q07 |
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| retapamulin | None | pleuromutilin (Code: N0000175433) Pleuromutilin Antibacterial (Code: N0000175434) | 2007-05-24 EMA 2007-04-12 FDA | 2OGO |
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| benziodarone | Baculoviral IAP repeat-containing protein 5 (Organism: Homo sapiens, class: Unclassified, accessions: O15392, gene: BIRC5, swissprot: BIRC5_HUMAN) | minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74) | Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) | |
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| gossypol | Bcl-2-like protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q07817, gene: BCL2L1, swissprot: B2CL1_HUMAN) Kinesin-like protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: P52732, gene: KIF11, swissprot: KIF11_HUMAN) Malate dehydrogenase, mitochondrial (Organism: Sus scrofa, class: Enzyme, accessions: P00346, gene: MDH2, swissprot: MDHM_PIG) Apoptosis regulator Bcl-2 (Organism: Homo sapiens, class: Cytosolic other, accessions: P10415, gene: BCL2, swissprot: BCL2_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) Malate dehydrogenase, cytoplasmic (Organism: Sus scrofa, class: Enzyme, accessions: P11708, gene: MDH1, swissprot: MDHC_PIG) Malate dehydrogenase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q6VVP7, gene: None, swissprot: Q6VVP7_PLAFA) Lactate dehydrogenase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q0PJ46, gene: LDH, swissprot: Q0PJ46_PLAFA) Apoptosis regulator Bcl-W (Organism: Homo sapiens, class: Cytosolic other, accessions: Q92843, gene: BCL2L2, swissprot: B2CL2_HUMAN) Induced myeloid leukemia cell differentiation protein Mcl-1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q07820, gene: MCL1, swissprot: MCL1_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer. | Contraceptive Agents (Code: D003270) Contraceptive Agents, Male (Code: D003272) Reproductive Control Agents (Code: D012102) | |
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| betamethasone butyrate propionate | a topical corticosteroid | |
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| glucametacin | indomethacin analog; structure | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | |
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| tenofovir disoproxil | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2), class: Polyprotein, accessions: P03369, gene: gag-pol, swissprot: POL_HV1A2) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) | Tenofovir disoproxil fumarate is the fumarate salt of the prodrug tenofovir disoproxil. Tenofovir disoproxil is absorbed and converted to the active substance tenofovir, which is a nucleoside monophosphate (nucleotide) analogue. Tenofovir is then converted to the active metabolite, tenofovir diphosphate, an obligate chain terminator, by constitutively expressed cellular enzymes. Tenofovir diphosphate has an intracellular half-life of 10 hours in activated and 50 hours in resting peripheral blood mononuclear cells (PBMCs). Tenofovir diphosphate inhibits HIV-1 reverse transcriptase and the HBV polymerase by direct binding competition with the natural deoxyribonucleotide substrate and, after incorporation into DNA, by DNA chain termination. Tenofovir diphosphate is a weak inhibitor of cellular polymerases alpha, beta, and gamma. At concentrations of up to 300 umol/l, tenofovir has also shown no effect on the synthesis of mitochondrial DNA or the production of lactic acid in in vitro assays. | prodrug (Code: CHEBI:50266) antiviral drug (Code: CHEBI:36044) | 2001-10-26 FDA | |
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| ceforanide | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1984-05-24 FDA | |
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| cefminox | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| atosiban | Oxytocin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30559, gene: OXTR, swissprot: OXYR_HUMAN) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Vasopressin V1b receptor (Organism: Homo sapiens, class: GPCR, accessions: P47901, gene: AVPR1B, swissprot: V1BR_HUMAN) Oxytocin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P70536, gene: Oxtr, swissprot: OXYR_RAT) | Atosiban is a synthetic peptide which is a competitive antagonist of human oxytocin at receptor level. In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence. | Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) Tocolytic Agents (Code: D015149) | 2000-01-20 EMA | |
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| estramustine phosphate | Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) Protein-tyrosine phosphatase 1C (Organism: Homo sapiens, class: Enzyme, accessions: P29350, gene: PTPN6, swissprot: PTN6_HUMAN) Tyrosine-protein phosphatase non-receptor type 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q06124, gene: PTPN11, swissprot: PTN11_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) | None | 1981-12-24 FDA | |
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| latamoxef | Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) Peptidoglycan synthase FtsI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD68, gene: ftsI, swissprot: FTSI_ECOLI) | Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | None FDA | |
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| perfluamine | None | blood substitute (Code: CHEBI:38849) | |
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| apalcillin | None | |
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| cefoselis | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| penfluridol | 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) | One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | |
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| falecalcitriol | None | 2001-04-04 PMDA | |
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| cefotiam | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Vasoactive intestinal polypeptide receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P32241, gene: VIPR1, swissprot: VIPR1_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | None FDA | |
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| protoverine | None | |
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| pirozadil | None | |
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| daunorubicin | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) Multidrug resistance-associated protein 6 (Organism: Homo sapiens, class: Transporter, accessions: O95255, gene: ABCC6, swissprot: MRP6_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) ORF 73 (Organism: Human herpesvirus 8, class: Unclassified, accessions: O40947, gene: None, swissprot: O40947_HHV8) | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. | Anthracycline Topoisomerase Inhibitor (Code: N0000175414) Anthracyclines (Code: N0000007530) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) | 1979-12-19 FDA | 110D 152D 1D10 1D11 1D33 1DA0 1JO2 1O0K 1VTH 1VTI 2D34 308D 3F8F 3TVB 427D 4KR8 |
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| pibrentasvir | Pibrentasvir is an inhibitor of HCV NS5A, which is essential for viral RNA replication and virion assembly. The mechanism of action of pibrentasvir has been characterized based on cell culture antiviral activity and drug resistance mapping studies. | 2017-08-03 FDA | |
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| rolitetracycline | A pyrrolidinylmethyl TETRACYCLINE. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) antiprotozoal drug (Code: CHEBI:35820) prodrug (Code: CHEBI:50266) | |
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| gliquidone | Sulfonylurea receptor 1, Kir6.2 (Organism: Homo sapiens, class: Ion channel, accessions: Q09428|Q14654, gene: ABCC8|KCNJ11, swissprot: ABCC8_HUMAN|KCJ11_HUMAN) | None | Hypoglycemic Agents (Code: D007004) | |
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| dutasteride | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18405, gene: SRD5A1, swissprot: S5A1_HUMAN) 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P31213, gene: SRD5A2, swissprot: S5A2_HUMAN) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) | A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA. | 5-alpha Reductase Inhibitor (Code: N0000175836) 5-alpha Reductase Inhibitors (Code: D058891) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Steroid Synthesis Inhibitors (Code: D065088) | 2001-11-20 FDA | |
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| dexamethasone acefurate | None | |
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| lumefantrine | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Lumefantrine is an antimalarial agent. Available data suggest lumefantrine inhibits the formation of beta-hematin by forming a complex with hemin. | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antimalarial (Code: CHEBI:38068) | 2009-04-07 FDA | |
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| niceritrol | An ester of nicotinic acid that lowers cholesterol and triglycerides in total plasma and in the VLD- and LD-lipoprotein fractions. | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| davercin | None | |
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| nilotinib | Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Organism: Homo sapiens, class: Kinase, accessions: Q8TBX8, gene: PIP4K2C, swissprot: PI42C_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Serine/threonine-protein kinase MRCK beta (Organism: Homo sapiens, class: Kinase, accessions: Q9Y5S2, gene: CDC42BPB, swissprot: MRCKB_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) Ephrin type-B receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29323, gene: EPHB2, swissprot: EPHB2_HUMAN) Mitogen-activated protein kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q15759, gene: MAPK11, swissprot: MK11_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Ephrin type-B receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P54753, gene: EPHB3, swissprot: EPHB3_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Bcr/Abl fusion protein (Organism: Homo sapiens, class: Kinase, accessions: P00519|P11274, gene: ABL1|BCR, swissprot: ABL1_HUMAN|BCR_HUMAN) | Nilotinib is an inhibitor of the BCR-ABL kinase. Nilotinib binds to and stabilizes the inactive conformation of the kinase domain of ABL protein. In vitro, nilotinib inhibited BCR-ABL mediated proliferation of murine leukemic cell lines and human cell lines derived from patients with Ph+ CML. Under the conditions of the assays, nilotinib was able to overcome imatinib resistance resulting from BCR-ABL kinase mutations, in 32 out of 33 mutations tested. In vivo, nilotinib reduced the tumor size in a murine BCR-ABL xenograft model. | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) antineoplastic agent (Code: CHEBI:35610) | 2007-10-29 FDA | 3CS9 3GP0 5MO4 |
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| rocuronium | Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) | Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. | Neuromuscular Nondepolarizing Blockade (Code: N0000175732) Nondepolarizing Neuromuscular Blocker (Code: N0000175720) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Peripheral Nervous System Agents (Code: D018373) neuromuscular agent (Code: CHEBI:51372) muscle relaxant (Code: CHEBI:51371) | 1994-03-17 FDA | |
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| proscillaridin | Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) | A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill). | Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) | 1967-01-01 YEAR INTRODUCED | |
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| deslanoside | Sodium/potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P05023|P05026|P13637|P14415|P50993|P54709|P54710|Q13733, gene: ATP1A1|ATP1A2|ATP1A3|ATP1A4|ATP1B1|ATP1B2|ATP1B3|FXYD2, swissprot: AT1A1_HUMAN|AT1A2_HUMAN|AT1A3_HUMAN|AT1A4_HUMAN|AT1B1_HUMAN|AT1B2_HUMAN|AT1B3_HUMAN|ATNG_HUMAN) | Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata. | Anti-Arrhythmia Agents (Code: D000889) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) anti-arrhythmia drug (Code: CHEBI:38070) cardiotonic drug (Code: CHEBI:38147) | None FDA | |
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| cortivazol | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Anti-Inflammatory Agents (Code: D000893) | |
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| tocopherol succinate | None | None FDA | |
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| ketoconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Potassium voltage-gated channel subfamily A member 10 (Organism: Homo sapiens, class: Ion channel, accessions: Q16322, gene: KCNA10, swissprot: KCA10_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q07973, gene: CYP24A1, swissprot: CP24A_HUMAN) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Cytochrome P450 11A1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P14137, gene: Cyp11a1, swissprot: CP11A_RAT) Cytochrome P450 24A1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q09128, gene: Cyp24a1, swissprot: CP24A_RAT) Gonadotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30969, gene: Gnrhr, swissprot: GNRHR_RAT) Cytochrome P450 7A1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P18125, gene: Cyp7a1, swissprot: CP7A1_RAT) Cytochrome P450 51 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q64654, gene: Cyp51a1, swissprot: CP51A_RAT) Cytochrome P450 11B1 (Organism: Bos taurus, class: Unclassified, accessions: P15150, gene: CYP11B1, swissprot: C11B1_BOVIN) Cytochrome P450 21 (Organism: Homo sapiens, class: Enzyme, accessions: P08686, gene: CYP21A2, swissprot: CP21A_HUMAN) Cytochrome P450 17A1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P11715, gene: Cyp17a1, swissprot: CP17A_RAT) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Organism: Mus musculus, class: Unclassified, accessions: O35084, gene: Cyp27b1, swissprot: CP27B_MOUSE) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A5 Inhibitors (Code: N0000190115) P-Glycoprotein Inhibitors (Code: N0000185503) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) | 1981-06-12 FDA | 6AYB 1JIN 1JIP 2JJP 2V0M 3LD6 3OZW 5LI8 |
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| terconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | None | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 1987-12-31 FDA | |
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| cefsulodin | Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) Beta-adrenergic receptor kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P25098, gene: GRK2, swissprot: ARBK1_HUMAN) Protein-tyrosine phosphatase 1C (Organism: Homo sapiens, class: Enzyme, accessions: P29350, gene: PTPN6, swissprot: PTN6_HUMAN) Tyrosine-protein phosphatase non-receptor type 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q06124, gene: PTPN11, swissprot: PTN11_HUMAN) tRNA 2'-phosphotransferase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Unclassified, accessions: Q5A7N4, gene: TPT1, swissprot: Q5A7N4_CANAL) | A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1981-01-01 YEAR INTRODUCED | |
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| ciclesonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | nasal spray approved for seasonal and perennial allergic rhinitis | Adrenal Cortex Hormones (Code: D000305) Anti-Allergic Agents (Code: D018926) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 2006-10-20 FDA | |
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| aprepitant | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Neuromedin-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P29371, gene: TACR3, swissprot: NK3R_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Substance-P receptor (Organism: Meriones unguiculatus, class: Unclassified, accessions: Q5DUB1, gene: TACR1, swissprot: NK1R_MERUN) | Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV). Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurokinin-1 Receptor Antagonists (Code: D064729) Neurotransmitter Agents (Code: D018377) Neurokinin 1 Antagonists (Code: N0000010262) Substance P/Neurokinin-1 Receptor Antagonist (Code: N0000175786) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 3A4 Inducers (Code: N0000185506) Peripheral Nervous System Agents (Code: D018373) antidepressant (Code: CHEBI:35469) antiemetic (Code: CHEBI:50919) peripheral nervous system drug (Code: CHEBI:49110) | 2003-03-27 FDA | |
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| cetalkonium chloride | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Surface-Active Agents (Code: D013501) | |
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| tocopheryl nicotinate | None | |
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| ambenonium | Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | A quaternary ammonium compound that is an inhibitor of cholinesterase activity with actions similar to those of NEOSTIGMINE, but of longer duration. Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112) | Cholinesterase Inhibitor (Code: N0000175723) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | 1956-05-01 FDA | |
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| nafiverine | None | |
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| mezlocillin | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Serum albumin (Organism: Homo sapiens, class: Secreted, accessions: P02768, gene: ALB, swissprot: ALBU_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Interleukin-8 (Organism: Homo sapiens, class: Cytokine, accessions: P10145, gene: CXCL8, swissprot: IL8_HUMAN) Cytochrome P450 2C8 (Organism: Homo sapiens, class: Enzyme, accessions: P10632, gene: CYP2C8, swissprot: CP2C8_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Interleukin-1 receptor type 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: P14778, gene: IL1R1, swissprot: IL1R1_HUMAN) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cannabinoid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P34972, gene: CNR2, swissprot: CNR2_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin E2 receptor EP4 subtype (Organism: Homo sapiens, class: GPCR, accessions: P35408, gene: PTGER4, swissprot: PE2R4_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Prostaglandin-H2 D-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: P41222, gene: PTGDS, swissprot: PTGDS_HUMAN) Aldo-keto reductase family 1 member C3 (Organism: Homo sapiens, class: Enzyme, accessions: P42330, gene: AKR1C3, swissprot: AK1C3_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCR9, gene: PDE11A, swissprot: PDE11_HUMAN) Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1981-09-21 FDA | |
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| amenamevir | Amenamevir is an anti-herpes virus agent for the treatment of herpes zoster (shingles) with a novel mechanism of action. Amenamevir has been observed to inhibit the proliferation of the varicella-zoster virus by inhibiting the activity of the helicase-primase complex, which is essential for viral DNA replication. | 2016-07-03 PMDA | |
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| netarsudil | Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) | Netarsudil is a rho kinase inhibitor, which is believed to reduce IOP by increasing the outflow of aqueous humor through the trabecular meshwork route. | 2017-12-18 FDA | |
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| benzalkonium | A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics. | None FDA | |
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| romidepsin | Histone deacetylase (Organism: Homo sapiens, class: Enzyme, accessions: O15379|P56524|Q13547|Q8WUI4|Q92769|Q969S8|Q96DB2|Q9BY41|Q9UBN7|Q9UKV0|Q9UQL6, gene: HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9, swissprot: HDA10_HUMAN|HDA11_HUMAN|HDAC1_HUMAN|HDAC2_HUMAN|HDAC3_HUMAN|HDAC4_HUMAN|HDAC5_HUMAN|HDAC6_HUMAN|HDAC7_HUMAN|HDAC8_HUMAN|HDAC9_HUMAN) Histone deacetylase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P56524, gene: HDAC4, swissprot: HDAC4_HUMAN) Histone deacetylase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q8WUI4, gene: HDAC7, swissprot: HDAC7_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) Histone deacetylase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKV0, gene: HDAC9, swissprot: HDAC9_HUMAN) Histone deacetylase 5 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UQL6, gene: HDAC5, swissprot: HDAC5_HUMAN) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) Histone deacetylase 6 (Organism: Mus musculus, class: Unclassified, accessions: Q9Z2V5, gene: Hdac6, swissprot: HDAC6_MOUSE) Histone deacetylase 3/NCoR1 (Organism: Homo sapiens, class: Transcription factor, accessions: O15379|O75376, gene: HDAC3|NCOR1, swissprot: HDAC3_HUMAN|NCOR1_HUMAN) Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Organism: Homo sapiens, class: Transcription factor, accessions: O15379|Q9Y618, gene: HDAC3|NCOR2, swissprot: HDAC3_HUMAN|NCOR2_HUMAN) | a bicyclic depsipeptide and a potent histone deacetylase inhibitor from Chromobacterium violaceum | Histone Deacetylase Inhibitor (Code: N0000175588) Histone Deacetylase Inhibitors (Code: N0000175071) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) antineoplastic agent (Code: CHEBI:35610) | 2009-11-05 FDA | |
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| cefonicid | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | None FDA | |
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| pantethine | None | nutraceutical (Code: CHEBI:50733) | None FDA | |
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| epirubicin | Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) NS3 (Organism: Hepatitis C virus, class: Enzyme, accessions: A3EZI9, gene: NS3, swissprot: A3EZI9_9HEPC) DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Anthracycline Topoisomerase Inhibitor (Code: N0000175414) Anthracyclines (Code: N0000007530) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) | 1999-09-15 FDA | 1D15 1D54 1D58 1QDA |
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| doxorubicin | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Caspase-1 (Organism: Homo sapiens, class: Enzyme, accessions: P29466, gene: CASP1, swissprot: CASP1_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Multidrug resistance-associated protein 6 (Organism: Homo sapiens, class: Transporter, accessions: O95255, gene: ABCC6, swissprot: MRP6_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Telomerase reverse transcriptase (Organism: Homo sapiens, class: Enzyme, accessions: O14746, gene: TERT, swissprot: TERT_HUMAN) DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) Type-2 restriction enzyme HindIII (Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), class: Unclassified, accessions: P43870, gene: hindIIIR, swissprot: T2D3_HAEIN) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) Type-2 restriction enzyme ScaI (Organism: Streptomyces caespitosus, class: Unclassified, accessions: O52691, gene: scaIR, swissprot: T2S1_STRCS) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Ribonuclease pancreatic (Organism: Bos taurus, class: Enzyme, accessions: P61823, gene: RNASE1, swissprot: RNAS1_BOVIN) Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) ORF 73 (Organism: Human herpesvirus 8, class: Unclassified, accessions: O40947, gene: None, swissprot: O40947_HHV8) UDP-galactopyranose mutase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WIQ1, gene: glf, swissprot: GLF_MYCTU) | Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. | Anthracycline Topoisomerase Inhibitor (Code: N0000175414) Anthracyclines (Code: N0000007530) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1974-08-07 FDA | 151D 1D12 1DA9 1I1E 1P20 2DR6 4DX7 4ZVM 5MRA |
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| prednisolone sulfobenzoate | None | |
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| meproscillarin | Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) | semi-synthetic derivative of proscillaridin of Scilla (Liliaceae); structure in Negwer, 5th ed, #6625; RN given refers to (3beta)-isomer | |
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| octotiamine | None | |
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| everolimus | Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) Serine/threonine-protein kinase mTOR (Organism: Homo sapiens, class: Kinase, accessions: P42345, gene: MTOR, swissprot: MTOR_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT. | Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) mTOR Inhibitor Immunosuppressant (Code: N0000175625) mTOR Inhibitors (Code: N0000175624) Decreased Immunologic Activity (Code: N0000175550) immunosuppressive agent (Code: CHEBI:35705) antineoplastic agent (Code: CHEBI:35610) | 2011-09-02 EMA 2009-03-30 FDA | |
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| ceftazidime | Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) Peptidoglycan synthase FtsI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD68, gene: ftsI, swissprot: FTSI_ECOLI) | Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) drug allergen (Code: CHEBI:88188) | 1985-07-19 FDA | |
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| cefazedone | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | |
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| peruvoside | None | |
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| fluphenazine enanthate | Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1967-03-15 FDA | |
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| octenidine | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) | |
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| bufeniode | None | |
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| alpha-Ergocryptine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | a component of the ergotoxine complex; it is the main ergot alkaloid of Japanese & South American wid grasses; minor descriptor (76-86); on-line & INDEX MEDICUS search ERGOLINES (76-86); RN given refers to ((5'alpha)-isomer) | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | |
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| bosentan | Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Endothelin-1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P26684, gene: Ednra, swissprot: EDNRA_RAT) Endothelin-1 receptor (Organism: Sus scrofa, class: GPCR, accessions: Q29010, gene: EDNRA, swissprot: EDNRA_PIG) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) Endothelin B receptor (Organism: Homo sapiens, class: GPCR, accessions: P24530, gene: EDNRB, swissprot: EDNRB_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Endothelin B receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P21451, gene: Ednrb, swissprot: EDNRB_RAT) | a specific and competitive antagonist at endothelin receptor types ETA and ETB, has a slightly higher affinity for ETA receptors than for ETB receptors, indicated for the treatment of pulmonary arterial hypertension | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Endothelin Receptor Antagonists (Code: D065128) antihypertensive agent (Code: CHEBI:35674) endothelin receptor antagonist (Code: CHEBI:51451) | 2001-11-20 FDA | 5XPR |
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| aliskiren | Renin (Organism: Homo sapiens, class: Enzyme, accessions: P00797, gene: REN, swissprot: RENI_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Renin (Organism: Callithrix jacchus, class: Enzyme, accessions: Q9TSZ1, gene: REN, swissprot: RENI_CALJA) Renin (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: Q7M3D2, gene: None, swissprot: Q7M3D2_RABIT) Renin (Organism: Macaca fascicularis, class: Enzyme, accessions: Q6DLS0, gene: REN, swissprot: RENI_MACFA) Renin-1 (Organism: Mus musculus, class: Enzyme, accessions: P06281, gene: Ren1, swissprot: RENI1_MOUSE) Renin (Organism: Rattus norvegicus, class: Enzyme, accessions: P08424, gene: Ren1, swissprot: RENI_RAT) | Renin is secreted by the kidney in response to decreases in blood volume and renal perfusion. Renin cleaves angiotensinogen to form the inactive decapeptide angiotensin I (Ang I). Ang I is converted to the active octapeptide angiotensin II (Ang II) by ACE and non-ACE pathways. Ang II is a powerful vasoconstrictor and leads to the release of catecholamines from the adrenal medulla and prejunctional nerve endings. It also promotes aldosterone secretion and sodium reabsorption. Together, these effects increase blood pressure. Ang II also inhibits renin release, thus providing a negative feedback to the system. This cycle, from renin through angiotensin to aldosterone and its associated negative feedback loop, is known as the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a direct renin inhibitor, decreasing plasma renin activity (PRA) and inhibiting the conversion of angiotensinogen to Ang I. Whether aliskiren affects other RAAS components, e.g., ACE or non-ACE pathways, is not known. | Renin Inhibitor (Code: N0000175900) Renin Inhibitors (Code: N0000175899) antihypertensive agent (Code: CHEBI:35674) | 2007-03-05 FDA | 2V0Z |
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| arbekacin | None | Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 6CGG |
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| ceftriaxone | Penicillin-binding protein 2 (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD65, gene: mrdA, swissprot: PBP2_ECOLI) Penicillin-binding protein 1B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02919, gene: mrcB, swissprot: PBPB_ECOLI) Penicillin-binding protein 1A (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918, gene: mrcA, swissprot: PBPA_ECOLI) Peptidoglycan synthase FtsI (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AD68, gene: ftsI, swissprot: FTSI_ECOLI) D-amino-acid oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P14920, gene: DAO, swissprot: OXDA_HUMAN) | A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) drug allergen (Code: CHEBI:88188) | 1984-12-21 FDA | |
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| dronedarone | Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Potassium voltage-gated channel subfamily KQT member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O43526, gene: KCNQ2, swissprot: KCNQ2_HUMAN) Voltage-dependent calcium channel gamma-1 subunit (Organism: Homo sapiens, class: Ion channel, accessions: Q06432, gene: CACNG1, swissprot: CCG1_HUMAN) THAP domain-containing protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9NVV9, gene: THAP1, swissprot: THAP1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Organism: Homo sapiens, class: Ion channel, accessions: O60741, gene: HCN1, swissprot: HCN1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UL51, gene: HCN2, swissprot: HCN2_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9P1Z3, gene: HCN3, swissprot: HCN3_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Thyroid hormone receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827, gene: THRA, swissprot: THA_HUMAN) | Dronedarone has antiarrhythmic properties belonging to all four Vaughan-Williams classes, but the contribution of each of these activities to the clinical effect is unknown. | Antiarrhythmic (Code: N0000175426) anti-arrhythmia drug (Code: CHEBI:38070) | 2009-07-01 FDA | |
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| demecarium | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | major descriptor (65-85); on-line search AMMONIUM COMPOUNDS (66-85); Index Medicus search DEMECARIUM BROMIDE (65-85) | Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) | 1959-08-05 FDA | |
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| perflunafene | None | solvent (Code: CHEBI:46787) blood substitute (Code: CHEBI:38849) | |
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| acetrizoic acid | An iodinated radiographic contrast medium used as acetrizoate sodium in HYSTEROSALPINGOGRAPHY. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | None FDA | |
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| voacamine | None | |
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| ertugliflozin | Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) | SGLT2 is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. Ertugliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, ertugliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion. | 2017-12-19 FDA | |
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| cefpodoxime proxetil | None | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1992-08-07 FDA | |
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| vecuronium | Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) | Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. | Neuromuscular Nondepolarizing Blockade (Code: N0000175732) Nondepolarizing Neuromuscular Blocker (Code: N0000175720) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) nicotinic antagonist (Code: CHEBI:48878) neuromuscular agent (Code: CHEBI:51372) muscle relaxant (Code: CHEBI:51371) | 1984-04-30 FDA | |
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| phenobutiodil | None | |
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| alatrofloxacin | Topoisomerase IV (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AFI2|P20083, gene: parC|parE, swissprot: PARC_ECOLI|PARE_ECOLI) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) | prodrug of trovafloxacin | Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1997-12-18 FDA | |
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| deferoxamine | iron (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) Hypoxia-inducible factor 1-alpha (Organism: Homo sapiens, class: Transcription factor, accessions: Q16665, gene: HIF1A, swissprot: HIF1A_HUMAN) | Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. | Iron Chelating Activity (Code: N0000000144) Iron Chelator (Code: N0000175522) Chelating Agents (Code: D002614) Iron Chelating Agents (Code: D007502) Sequestering Agents (Code: D064449) Siderophores (Code: D017262) antidote (Code: CHEBI:50247) | 1968-04-01 FDA | |
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| olmesartan medoxomil | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1 angiotensin II receptor (Organism: Bos taurus, class: GPCR, accessions: P25104, gene: AGTR1, swissprot: AGTR1_BOVIN) | Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | 2002-04-25 FDA | |
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| lividomycin | None | 2ESJ 2FD0 3C5D 6CEY |
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| atorvastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P51639, gene: Hmgcr, swissprot: HMDH_RAT) 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Sus scrofa, class: Unclassified, accessions: Q1W675, gene: HMGCR, swissprot: HMDH_PIG) | A pyrrole and heptanoic acid derivative,HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; AND TRIGLYCERIDES and to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS and prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors. | HMG-CoA Reductase Inhibitor (Code: N0000175589) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 1996-12-17 FDA | 1HWK |
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| halopredone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | |
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| sulfamazone | None | antibacterial drug (Code: CHEBI:36047) antipyretic (Code: CHEBI:35493) | |
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| protoporphyrin | Cytoplasmic zinc-finger protein (Organism: Caenorhabditis elegans, class: Unclassified, accessions: G5EF15, gene: pos-1, swissprot: G5EF15_CAEEL) Zinc finger protein mex-5 (Organism: Caenorhabditis elegans, class: Cytosolic other, accessions: Q9XUB2, gene: mex-5, swissprot: MEX5_CAEEL) | None | Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) photosensitizing agent (Code: CHEBI:47868) | 1HRS 1Z53 2HRE 2QD1 2QD5 2Y4E 4KLA 4UC1 5DUO 5E9Z |
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| ecamsule | an organic chemical agent capable of absorbing light throughout the entire UVA spectrum | 2006-07-21 FDA | |
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| fosinopril | Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) | A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat. | Angiotensin Converting Enzyme Inhibitor (Code: N0000175562) Angiotensin-Converting Enzyme Inhibitors (Code: D000806) Anti-Arrhythmia Agents (Code: D000889) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor (Code: CHEBI:35457) prodrug (Code: CHEBI:50266) antihypertensive agent (Code: CHEBI:35674) | 1991-05-16 FDA | |
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| dihydroergocornine | A 9,10alpha-dihydro derivative of ERGOTAMINE that contains isopropyl sidechains at the 2' and 5' positions of the molecule. | Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) | None FDA | |
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| deserpidine | Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) | minor descriptor (66-84); on-line search RESERPINE/AA (75-84), RESERPINE (66-74); Index Medicus search RESERPINE/AA (75-84), YOHIMBANS (69-74), RESERPINE (66-68); RN given refers to (3beta,16beta,17alpha,18beta,20alpha)-isomer | Catecholamine-depleting Sympatholytic (Code: N0000175640) Decreased Sympathetic Activity (Code: N0000175650) | 1957-04-19 FDA | |
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| enocitabine | None | Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antiviral Agents (Code: D000998) | |
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| desoxymycin | None | |
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| cefcapene pivoxil | None | |
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| nelfinavir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) | A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. | Protease Inhibitor (Code: N0000175889) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Cytochrome P450 3A Inhibitors (Code: N0000190114) Protease Inhibitors (Code: D011480) antineoplastic agent (Code: CHEBI:35610) | 1997-03-14 FDA | 1OHR 2PYM 2PYN 2Q63 2Q64 2QAK 2R5Q 3EKX 3EL0 3EL5 |
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| brovanexine | None | |
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| zotarolimus | Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) | synthetic analog of rapamycin | |
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| cefuroxime pivoxetil | None | |
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| formocortal | None | |
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| isepamicin | Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Organism: Escherichia coli, class: Enzyme, accessions: O32553, gene: mphB, swissprot: O32553_ECOLX) | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1988-01-01 YEAR INTRODUCED | |
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| iodol | None | |
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| diathymosulfone | None | |
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| doxacurium | Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) | according to Unlisted Drugs, BW-A938U is a bis-benzylisoquinolinium diester and a highly potent neuromuscular blocker | Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Peripheral Nervous System Agents (Code: D018373) muscle relaxant (Code: CHEBI:51371) | 1991-03-07 FDA | |
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| carbenoxolone | Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Homo sapiens, class: Enzyme, accessions: P28845, gene: HSD11B1, swissprot: DHI1_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 2 (Organism: Mus musculus, class: Enzyme, accessions: P51661, gene: Hsd11b2, swissprot: DHI2_MOUSE) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Mus musculus, class: Enzyme, accessions: P50172, gene: Hsd11b1, swissprot: DHI1_MOUSE) | An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. | Anti-Ulcer Agents (Code: D000897) Gastrointestinal Agents (Code: D005765) | 1HDC 2BEL |
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| iopanoic acid | Radiopaque medium used as diagnostic aid. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1951-07-16 FDA | |
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| iophenoic acid | None | 2YDF |
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| myrophine | None | prodrug (Code: CHEBI:50266) opioid analgesic (Code: CHEBI:35482) | |
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| clodantoin | None | |
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| cytarabine ocfosfate | None | |
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| cefotetan | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1985-12-27 FDA | |
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| zafirlukast | Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Mitogen-activated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P28482, gene: MAPK1, swissprot: MK01_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Leukotriene B4 receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q15722, gene: LTB4R, swissprot: LT4R1_HUMAN) Cysteinyl leukotriene receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9NS75, gene: CYSLTR2, swissprot: CLTR2_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Cysteinyl leukotriene receptor 1 (Organism: Cavia porcellus, class: GPCR, accessions: Q2NNR5, gene: CYSLTR1, swissprot: CLTR1_CAVPO) Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Cytosolic phospholipase A2 (Organism: Homo sapiens, class: Enzyme, accessions: P47712, gene: PLA2G4A, swissprot: PA24A_HUMAN) | a leukotriene D4 receptor antagonist | Leukotriene Receptor Antagonist (Code: N0000175777) Leukotriene Receptor Antagonists (Code: N0000000083) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) Anti-Asthmatic Agents (Code: D018927) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Leukotriene Antagonists (Code: D020024) Respiratory System Agents (Code: D019141) leukotriene antagonist (Code: CHEBI:49159) anti-asthmatic agent (Code: CHEBI:65023) | 1996-09-26 FDA | |
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| oleandrin | None | |
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| difebarbamate | None | |
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| clofenotane | Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) | synthetic insecticide used to combat malaria, typhus, and the other insect-borne human diseases | endocrine disruptor (Code: CHEBI:138015) bridged diphenyl acaricide (Code: CHEBI:39412) | 5KRA |
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| prednisolone farnesylate | None | |
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| lapatinib | Solute carrier organic anion transporter family member 1B1 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y6L6, gene: SLCO1B1, swissprot: SO1B1_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tubulin alpha-1A chain (Organism: Rattus norvegicus, class: Structural, accessions: P68370, gene: Tuba1a, swissprot: TBA1A_RAT) Phosphatidylinositol 4-kinase beta (Organism: Homo sapiens, class: Kinase, accessions: Q9UBF8, gene: PI4KB, swissprot: PI4KB_HUMAN) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: O75747, gene: PIK3C2G, swissprot: P3C2G_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Organism: Homo sapiens, class: Kinase, accessions: O00750, gene: PIK3C2B, swissprot: P3C2B_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O14733, gene: MAP2K7, swissprot: MP2K7_HUMAN) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) | an EGFR-ErbB-2 inhibitor | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) | 2008-06-10 EMA 2007-03-13 FDA | 1XKK 3BBT |
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| streptomycin | 30S ribosomal protein S12 (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Ribosomal protein, accessions: P9WH62, gene: rpsL, swissprot: RS12_MYCTO) | An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis. | Aminoglycoside Antibacterial (Code: N0000175477) Aminoglycosides (Code: N0000007853) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1946-02-18 FDA | 1FJG 1NTA 1NTB 3HAV 4DR3 4DR5 4DR6 4DR7 4DUZ 4DV1 4DV3 4DV5 4DV7 4EJW 4JI1 4JI3 4JI8 4NXN 5LUH |
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| ergotamine | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Cholecystokinin A receptor (Organism: Mus musculus, class: GPCR, accessions: O08786, gene: Cckar, swissprot: CCKAR_MOUSE) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Adenylate cyclase (Organism: Arthrospira platensis, class: Unclassified, accessions: O32393, gene: cyaC, swissprot: O32393_ARTPT) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Gastrin/cholecystokinin type B receptor (Organism: Mus musculus, class: GPCR, accessions: P56481, gene: Cckbr, swissprot: GASR_MOUSE) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 1F (Organism: Rattus norvegicus, class: Unclassified, accessions: P30940, gene: Htr1f, swissprot: 5HT1F_RAT) 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) 5-hydroxytryptamine receptor 5A (Organism: Rattus norvegicus, class: Unclassified, accessions: P35364, gene: Htr5a, swissprot: 5HT5A_RAT) | A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS. | Ergotamine Derivative (Code: N0000175766) Ergotamines (Code: N0000007621) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Neurotransmitter Agents (Code: D018377) Oxytocics (Code: D010120) Peripheral Nervous System Agents (Code: D018373) Reproductive Control Agents (Code: D012102) Sensory System Agents (Code: D018689) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Vasoconstrictor Agents (Code: D014662) non-narcotic analgesic (Code: CHEBI:35481) vasoconstrictor agent (Code: CHEBI:50514) serotonergic agonist (Code: CHEBI:35941) alpha-adrenergic agonist (Code: CHEBI:35569) | 1948-11-26 FDA | 4IAR 4IB4 4NC3 5TUD 6BQG |
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| azelnidipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | |
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| dihydrostreptomycin | A semi-synthetic aminoglycoside antibiotic that is used in the treatment of TUBERCULOSIS. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| dihydroergotamine | 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1F (Organism: Homo sapiens, class: GPCR, accessions: P30939, gene: HTR1F, swissprot: 5HT1F_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Gastrin/cholecystokinin type B receptor (Organism: Mus musculus, class: GPCR, accessions: P56481, gene: Cckbr, swissprot: GASR_MOUSE) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) | A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS. | Ergotamine Derivative (Code: N0000175766) Ergotamines (Code: N0000007621) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Vasoconstrictor Agents (Code: D014662) serotonergic agonist (Code: CHEBI:35941) non-narcotic analgesic (Code: CHEBI:35481) vasoconstrictor agent (Code: CHEBI:50514) dopamine agonist (Code: CHEBI:51065) sympatholytic agent (Code: CHEBI:66991) | 1946-04-12 FDA | 4IAQ |
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| ouabain | Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Signal transducer and activator of transcription 3 (Organism: Homo sapiens, class: Transcription factor, accessions: P40763, gene: STAT3, swissprot: STAT3_HUMAN) | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE. | Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) cardiotonic drug (Code: CHEBI:38147) anti-arrhythmia drug (Code: CHEBI:38070) | 1865-01-01 YEAR INTRODUCED | 1IBG 3A3Y 3N23 4HYT 4XE5 |
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| cefodizime | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1991-01-01 YEAR INTRODUCED | |
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| dilazep | Equilibrative nucleoside transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q99808, gene: SLC29A1, swissprot: S29A1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Equilibrative nucleoside transporter 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: O54699, gene: Slc29a2, swissprot: S29A2_RAT) | Coronary vasodilator with some antiarrhythmic activity. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| amikacin | Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) (Organism: Escherichia coli, class: Enzyme, accessions: O32553, gene: mphB, swissprot: O32553_ECOLX) | A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics. | Aminoglycoside Antibacterial (Code: N0000175477) Aminoglycosides (Code: N0000007853) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1981-01-22 FDA | 4P20 6CGD |
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| fosamprenavir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) | a prodrug of the protease inhibitor amprenavir | Protease Inhibitor (Code: N0000175889) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Protease Inhibitors (Code: D011480) prodrug (Code: CHEBI:50266) | 2003-10-20 FDA | |
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| tigecycline | Tigecycline inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains. In general, tigecycline is considered bacteriostatic; however, tigecycline has demonstrated bactericidal activity against isolates of S. pneumoniae and L. pneumophila. | Tetracycline-class Antibacterial (Code: N0000175938) Tetracyclines (Code: N0000007948) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 2005-06-15 FDA | 3V3O 4A6N 4ABZ 4V9B 4YHH 5J8A 5J91 |
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| montelukast | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) Cytochrome P450 2C8 (Organism: Homo sapiens, class: Enzyme, accessions: P10632, gene: CYP2C8, swissprot: CP2C8_HUMAN) Cysteinyl leukotriene receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9NS75, gene: CYSLTR2, swissprot: CLTR2_HUMAN) Cysteinyl leukotriene receptor 1 (Organism: Cavia porcellus, class: GPCR, accessions: Q2NNR5, gene: CYSLTR1, swissprot: CLTR1_CAVPO) Uracil nucleotide/cysteinyl leukotriene receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13304, gene: GPR17, swissprot: GPR17_HUMAN) Cysteinyl leukotriene receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y271, gene: CYSLTR1, swissprot: CLTR1_HUMAN) Uracil nucleotide/cysteinyl leukotriene receptor (Organism: Mus musculus, class: Unclassified, accessions: Q6NS65, gene: Gpr17, swissprot: GPR17_MOUSE) | Montelukast is an orally active compound that binds with high affinity and selectivity to the CysLT1 receptor (in preference to other pharmacologically important airway receptors, such as the prostanoid, cholinergic, or beta-adrenergic receptor). Montelukast inhibits physiologic actions of cysteinyl leukotriene LTD4 at the CysLT1 receptor without any agonist activity. | Leukotriene Receptor Antagonist (Code: N0000175777) Leukotriene Receptor Antagonists (Code: N0000000083) Anti-Asthmatic Agents (Code: D018927) Cytochrome P-450 CYP1A2 Inducers (Code: D065694) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Leukotriene Antagonists (Code: D020024) Metabolic Side Effects of Drugs and Substances (Code: D065606) Respiratory System Agents (Code: D019141) anti-arrhythmia drug (Code: CHEBI:38070) anti-asthmatic drug (Code: CHEBI:49167) leukotriene antagonist (Code: CHEBI:49159) | 1998-02-20 FDA | 2NNI |
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| hidrosmin | a benzopyrone derivative; water-soluble flavonoid | |
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| irinotecan | DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) | Irinotecan is a derivative of camptothecin. Camptothecins act as specific inhibitors of the enzyme DNA topoisomerase I. Irinotecan and its active metabolite SN-38 bind reversibly to the topoisomerase I-DNA complex and induce single-strand DNA lesions which block the DNA replication fork and are responsible for the cytotoxicity. Irinotecan is metabolized by carboxylesterase to SN-38. SN-38 is approximately 1000 times as potent as irinotecan as an inhibitor of topoisomerase I purified from human and rodent tumour cell lines. | Topoisomerase Inhibitor (Code: N0000175609) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Enzyme Inhibitors (Code: D004791) Radiation-Sensitizing Agents (Code: D011838) Topoisomerase I Inhibitors (Code: D059004) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) | 1996-06-14 FDA | 1U65 |
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| antrafenine | None | |
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| etoposide | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Canalicular multispecific organic anion transporter 2 (Organism: Homo sapiens, class: Transporter, accessions: O15438, gene: ABCC3, swissprot: MRP3_HUMAN) Multidrug resistance-associated protein 6 (Organism: Homo sapiens, class: Transporter, accessions: O95255, gene: ABCC6, swissprot: MRP6_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. | Topoisomerase Inhibitor (Code: N0000175609) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) | 1983-11-10 FDA | 3QX3 4LB9 5CDN 5CDP 5GWK |
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| rescimetol | None | |
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| fluphenazine decanoate | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) | None | 1972-06-20 FDA | |
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| hexobendine | Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | A potent vasoactive agent that dilates cerebral and coronary arteries, but slightly constricts femoral arteries, without any effects on heart rate, blood pressure or cardiac output. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| rapacuronium | Muscle-type nicotinic acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q04844|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNE|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHE_HUMAN|ACHG_HUMAN) | a nondepolarizing neuromuscular blocking agent with a rapid onset of action acts by competing for cholinergic receptors at the motor end plate | Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Peripheral Nervous System Agents (Code: D018373) | 1999-08-18 FDA | |
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| cefteram pivoxil | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| sultamicillin | contains ampicillin & sulbactam | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| selenium (75Se) tauroselcholic acid | None | |
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| keracyanin | an anthocyanin compound | |
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| perflubron | potential anti-obesity compound; reduces food adsorption; 8-carbon perfluorocarbon radiopaque compound; an oral contrast agent for use with MRI to enhance delineation of the bowel distinguishing it from adjacent organs | Anti-Obesity Agents (Code: D019440) Central Nervous System Agents (Code: D002491) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) Radiation-Sensitizing Agents (Code: D011838) radioopaque medium (Code: CHEBI:37338) blood substitute (Code: CHEBI:38849) | 1993-08-13 FDA | |
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| iopodic acid | Ionic monomeric contrast media. Usually the sodium or calcium salts are used for examination of the gall bladder and biliary tract. (From Martindale, The Extra Pharmacopoeia, 30th ed, p704) | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1962-03-15 FDA | |
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| metofenazate | None | |
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| hematoporphyrin | Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS. | photosensitizing agent (Code: CHEBI:47868) | |
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| nicofuranose | derivative of nicotinic acid that produces fewer side effects than pure nicotinic acid; used in peripheral vascular disease; also proposed as anticholesteremic; minor descriptor (75-84); on-line search NIACIN/AA (75-84); Index Medicus search NIACIN/AA (83-84), NICOTINIC ACIDS (75-82) | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| fulvestrant | Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) G-protein coupled estrogen receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q99527, gene: GPER1, swissprot: GPER1_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211, gene: Esr1, swissprot: ESR1_RAT) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) Steroid hormone receptor ERR1 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11474, gene: ESRRA, swissprot: ERR1_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | None | Selective Estrogen Receptor Modulators (Code: N0000000168) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Estrogen Antagonists (Code: D004965) Estrogen Receptor Antagonists (Code: D065171) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) estrogen receptor antagonist (Code: CHEBI:50792) antineoplastic agent (Code: CHEBI:35610) estrogen antagonist (Code: CHEBI:50837) | 2004-03-10 EMA 2002-04-25 FDA | 4J03 |
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| anazolene | None | |
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| diosmin | A bioflavonoid that strengthens vascular walls. | anti-inflammatory agent (Code: CHEBI:67079) | |
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| reserpine | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Chromaffin granule amine transporter (Organism: Homo sapiens, class: Transporter, accessions: P54219, gene: SLC18A1, swissprot: VMAT1_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Quinolone resistance protein NorA (Organism: Staphylococcus aureus, class: Transporter, accessions: P0A0J7, gene: norA, swissprot: NORA_STAAU) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Synaptic vesicular amine transporter (Organism: Bos taurus, class: Transporter, accessions: Q27963, gene: SLC18A2, swissprot: VMAT2_BOVIN) | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. | Catecholamine-depleting Sympatholytic (Code: N0000175640) Decreased Sympathetic Activity (Code: N0000175650) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antihypertensive Agents (Code: D000959) Antipsychotic Agents (Code: D014150) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) first generation antipsychotic (Code: CHEBI:65190) adrenergic uptake inhibitor (Code: CHEBI:35640) antihypertensive agent (Code: CHEBI:35674) | 1955-10-12 FDA | |
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| methoserpidine | None | |
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| dexniguldipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Voltage-gated L-type calcium channel (Organism: Rattus norvegicus, class: Ion channel, accessions: P22002|P27732|Q02485, gene: Cacna1c|Cacna1d|Cacna1s, swissprot: CAC1C_RAT|CAC1D_RAT|CAC1S_RAT) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) | None | |
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| tubocurarine | Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|Q15822, gene: CHRNA2|CHRNB2, swissprot: ACHA2_HUMAN|ACHB2_HUMAN) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Small conductance calcium-activated potassium channel protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UGI6, gene: KCNN3, swissprot: KCNN3_HUMAN) Small conductance calcium-activated potassium channel protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q92952, gene: KCNN1, swissprot: KCNN1_HUMAN) Serotonin 3 receptor (5HT3) (Organism: Homo sapiens, class: Ion channel, accessions: O95264|P46098, gene: HTR3A|HTR3B, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN) Small conductance calcium-activated potassium channel protein 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9H2S1, gene: KCNN2, swissprot: KCNN2_HUMAN) Small conductance calcium-activated potassium channel protein 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P70605, gene: Kcnn3, swissprot: KCNN3_RAT) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Zinc-activated ligand-gated ion channel (Organism: Homo sapiens, class: Ion channel, accessions: Q401N2, gene: ZACN, swissprot: ZACN_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Nicotinic acetylcholine receptor alpha 5 subunit (Organism: Musca domestica, class: Ion channel, accessions: A9XFY4, gene: nAChRalpha5, swissprot: A9XFY4_MUSDO) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) | A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae. | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) nicotinic antagonist (Code: CHEBI:48878) muscle relaxant (Code: CHEBI:51371) | 1945-02-20 FDA | 2XYT |
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| candesartan cilexetil | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Type-1 angiotensin II receptor (Organism: Bos taurus, class: GPCR, accessions: P25104, gene: AGTR1, swissprot: AGTR1_BOVIN) Type-1 angiotensin II receptor (Organism: Oryctolagus cuniculus, class: GPCR, accessions: P34976, gene: AGTR1, swissprot: AGTR1_RABIT) | a nonpeptide angiotensin II receptor antagonist | Angiotensin 2 Receptor Antagonists (Code: N0000000070) Angiotensin 2 Receptor Blocker (Code: N0000175561) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | 1998-06-04 FDA | |
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| manidipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) | None | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| dihydroergocristine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) 5-hydroxytryptamine receptor 4 (Organism: Cavia porcellus, class: GPCR, accessions: O70528, gene: HTR4, swissprot: 5HT4R_CAVPO) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) | A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position of the molecule. | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) alpha-adrenergic antagonist (Code: CHEBI:37890) vasodilator agent (Code: CHEBI:35620) | 1975-01-01 YEAR INTRODUCED | |
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| novobiocin | ParE (Organism: Streptococcus pneumoniae, class: Enzyme, accessions: Q7X1P7, gene: parE, swissprot: Q7X1P7_STREE) DNA gyrase subunit B (Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4), class: Enzyme, accessions: P0A4L9, gene: gyrB, swissprot: GYRB_STRPN) DNA gyrase subunit B (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES6, gene: gyrB, swissprot: GYRB_ECOLI) DNA gyrase subunit B (Organism: Mycobacterium smegmatis, class: Unclassified, accessions: P0C559, gene: gyrB, swissprot: GYRB_MYCSM) DNA gyrase subunit B (Organism: Escherichia coli, class: Enzyme, accessions: C3SLN2, gene: gyrB, swissprot: C3SLN2_ECOLX) DNA gyrase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AES4|P0AES6, gene: gyrA|gyrB, swissprot: GYRA_ECOLI|GYRB_ECOLI) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) DNA gyrase (Organism: Staphylococcus epidermidis (strain ATCC 35984 / RP62A), class: Enzyme, accessions: Q5HK03|Q5HK04, gene: gyrA|gyrB, swissprot: GYRA_STAEQ|GYRB_STAEQ) DNA gyrase subunit B (Organism: Staphylococcus aureus, class: Unclassified, accessions: P0A0K8, gene: gyrB, swissprot: GYRB_STAAU) | An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1964-09-04 FDA | 1AJ6 1KIJ 1S14 3LPS 4URN 4URO 6B89 |
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| dexamethasone palmitate | Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Mineralocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P08235, gene: NR3C2, swissprot: MCR_HUMAN) Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | a liposteroid for treatment of hemophagocytic lymphohistiocytosis | |
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| cefpiramide | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | antipseudomonal cephalosporin derivative | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1989-01-31 FDA | |
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| indinavir | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Protease (Organism: Human rhinovirus sp, class: Enzyme, accessions: Q4U254, gene: protease, swissprot: Q4U254_9ENTO) Protease (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9YQ12, gene: protease, swissprot: Q9YQ12_9HIV1) | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. | Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Protease Inhibitors (Code: D011480) | 1996-03-13 FDA | 1C6Y 1HSG 1HSH 1K6C 1SDT 1SDU 1SDV 1SGU 2AVO 2AVS 2AVV 2B7Z 2BPX 2R5P 3WSJ |
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| iotalamic acid | A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1963-09-30 FDA | |
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| diatrizoate | A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1954-11-26 FDA | |
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| framycetin | Phenylalanine--tRNA ligase alpha subunit (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P08312, gene: pheS, swissprot: SYFA_ECOLI) Phenylalanine--tRNA ligase beta subunit (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P07395, gene: pheT, swissprot: SYFB_ECOLI) 30S ribosomal protein S12 (Organism: Escherichia coli (strain K12), class: Cytosolic other, accessions: P0A7S3, gene: rpsL, swissprot: RS12_ECOLI) Extracellular calcium-sensing receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P48442, gene: Casr, swissprot: CASR_RAT) | A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1I9V 2A04 2B0Q 2ET4 2FCY 3C7R 4LF6 4LFB 4V52 4V57 4V9C 4W29 5DV4 5IQE |
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| paromomycin | An oligosaccharide antibiotic produced by various STREPTOMYCES. | Antiprotozoal (Code: N0000175485) Amebicides (Code: D000563) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antibacterial drug (Code: CHEBI:36047) antiprotozoal drug (Code: CHEBI:35820) anthelminthic drug (Code: CHEBI:35443) antiparasitic agent (Code: CHEBI:35442) | 1969-03-24 FDA | 1FJG 1IBK 1IBL 1J7T 1N32 1N33 1VVJ 1XMO 1XMQ 1XNQ 1XNR 2O3W 2UU9 2UUA 2UUB 2UUC 2UXB 2UXC 2UXD 2VQE 2VQF 2VQY 3BNQ 3BNR 3C44 3T1H 3T1Y 4DR2 4DR4 4GKJ 4GKK 4JYA 4KHP 4L47 4L71 4LEL 4LF7 4LF8 4LNT 4LSK 4LT8 4P6F 4P70 4QB9 4TUA 4TUB 4TUD 4TUE 4V51 4V5C 4V5D 4V5G 4V5L 4V5Y 4V8C 4V8F 4V8J 4V97 4WOI 4WRA 4WSD 4WT8 4X62 4X64 4X65 4X66 4ZC7 5BR8 5EL6 5EL7 5IB7 5NDV 5ZEJ |
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| cefditoren pivoxil | Penicillin-binding protein (Organism: Streptococcus pyogenes, class: Unclassified, accessions: Q54906, gene: dacA, swissprot: Q54906_STRPY) Penicillin-binding protein 3 (Organism: Haemophilus influenzae, class: Unclassified, accessions: Q14TG6, gene: pbp3, swissprot: Q14TG6_HAEIF) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | None | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) prodrug (Code: CHEBI:50266) | 2001-08-29 FDA | |
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| butobendine | None | Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) | |
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| tiratricol | Proliferating cell nuclear antigen (Organism: Homo sapiens, class: Unclassified, accessions: P12004, gene: PCNA, swissprot: PCNA_HUMAN) Thyroid hormone receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827, gene: THRA, swissprot: THA_HUMAN) Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Thyroid hormone receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10828, gene: THRB, swissprot: THB_HUMAN) Thyroid hormone receptor beta (Organism: Rattus norvegicus, class: Transcription factor, accessions: P18113, gene: Thrb, swissprot: THB_RAT) | None | 1NQ0 1NQ1 1NQ2 1NUO 2PIN 2PIT 2PIU 2PKL 2QPY 3D57 3JZB 3JZC 4YX9 |
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| sulfobromophthalein | Hematopoietic prostaglandin D synthase (Organism: Homo sapiens, class: Enzyme, accessions: O60760, gene: HPGDS, swissprot: HPGDS_HUMAN) | A phenolphthalein that is used as a diagnostic aid in hepatic function determination. | Coloring Agents (Code: D004396) Indicators and Reagents (Code: D007202) dye (Code: CHEBI:37958) | 19GS |
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| triamcinolone benetonide | None | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| tirilazad | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) | a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox | Antioxidants (Code: D000975) Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) | |
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| guamecycline | None | |
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| tocofibrate | None | |
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| cefbuperazone | None | |
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| dabigatran etexilate | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Trypsin (Organism: Homo sapiens, class: Enzyme, accessions: P07477|P07478|P35030, gene: PRSS1|PRSS2|PRSS3, swissprot: TRY1_HUMAN|TRY2_HUMAN|TRY3_HUMAN) Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Vitamin K-dependent protein C (Organism: Homo sapiens, class: Enzyme, accessions: P04070, gene: PROC, swissprot: PROC_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Tissue-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00750, gene: PLAT, swissprot: TPA_HUMAN) Serine protease hepsin (Organism: Homo sapiens, class: Enzyme, accessions: P05981, gene: HPN, swissprot: HEPS_HUMAN) | A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation. | Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) prodrug (Code: CHEBI:50266) | 2010-10-19 FDA | |
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| bemotrizinol | None | None FDA | |
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| metrizoic acid | A diagnostic radiopaque that usually occurs as the sodium salt. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1973-11-17 FDA | |
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| iodamide | An ionic monomeric contrast medium. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1978-07-25 FDA | |
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| efonidipine | Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Diuretics (Code: D004232) Membrane Transport Modulators (Code: D049990) Natriuretic Agents (Code: D045283) | |
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| rescinnamine | Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) | None | antihypertensive agent (Code: CHEBI:35674) | 1956-10-31 FDA | |
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| cefoperazone | Penicillin-binding protein 1A (Organism: Clostridium perfringens (strain 13 / Type A), class: Enzyme, accessions: Q8XJ01, gene: pbpA, swissprot: PBPA_CLOPE) Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections. | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 1982-11-18 FDA | |
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| nicomol | None | |
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| tyropanoate | A diagnostic aid as a radiopaque medium in cholecystography. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1969-10-24 FDA | |
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| amiodarone | Sodium channel protein type 5 subunit alpha (Organism: Rattus norvegicus, class: Unclassified, accessions: P15389, gene: Scn5a, swissprot: SCN5A_RAT) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) C-C chemokine receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P41597, gene: CCR2, swissprot: CCR2_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) B2 bradykinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30411, gene: BDKRB2, swissprot: BKRB2_HUMAN) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) C-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P51679, gene: CCR4, swissprot: CCR4_HUMAN) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Thyroid hormone receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10828, gene: THRB, swissprot: THB_HUMAN) Thyroid hormone receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827, gene: THRA, swissprot: THA_HUMAN) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Organism: Homo sapiens, class: Enzyme, accessions: Q15125, gene: EBP, swissprot: EBP_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Potassium voltage-gated channel subfamily A member 7 (Organism: Homo sapiens, class: Ion channel, accessions: Q96RP8, gene: KCNA7, swissprot: KCNA7_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) Voltage-dependent T-type calcium channel subunit alpha-1H (Organism: Homo sapiens, class: Ion channel, accessions: O95180, gene: CACNA1H, swissprot: CAC1H_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) THAP domain-containing protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9NVV9, gene: THAP1, swissprot: THAP1_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Lethal factor (Organism: Bacillus anthracis, class: Enzyme, accessions: P15917, gene: lef, swissprot: LEF_BACAN) C-8 sterol isomerase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P32352, gene: ERG2, swissprot: ERG2_YEAST) Squalene monooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: Q14534, gene: SQLE, swissprot: ERG1_HUMAN) Squalene synthase (Organism: Homo sapiens, class: Enzyme, accessions: P37268, gene: FDFT1, swissprot: FDFT_HUMAN) | An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. | Antiarrhythmic (Code: N0000175426) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 1A2 Inhibitors (Code: N0000182138) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Cytochrome P-450 CYP1A2 Inhibitors (Code: D065609) Cytochrome P-450 CYP2C9 Inhibitors (Code: D065688) Cytochrome P-450 CYP2D6 Inhibitors (Code: D065690) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Metabolic Side Effects of Drugs and Substances (Code: D065606) Potassium Channel Blockers (Code: D026902) Sodium Channel Blockers (Code: D026941) Vasodilator Agents (Code: D014665) cardiovascular drug (Code: CHEBI:35554) | 1985-12-24 FDA | 4O8Z 5H4D |
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| acarbose | Maltase-glucoamylase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: O43451, gene: MGAM, swissprot: MGA_HUMAN) Sucrase-isomaltase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: P14410, gene: SI, swissprot: SUIS_HUMAN) Lysosomal alpha-glucosidase (Organism: Homo sapiens, class: Enzyme, accessions: P10253, gene: GAA, swissprot: LYAG_HUMAN) Oligo-1,6-glucosidase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Unclassified, accessions: P53051, gene: IMA1, swissprot: MALX3_YEAST) Lysosomal alpha-glucosidase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q6P7A9, gene: Gaa, swissprot: LYAG_RAT) Alpha-amylase (Organism: Geobacillus stearothermophilus, class: Enzyme, accessions: P94451, gene: None, swissprot: P94451_GEOSE) Sucrase-isomaltase, intestinal (Organism: Rattus norvegicus, class: Enzyme, accessions: P23739, gene: Si, swissprot: SUIS_RAT) Alpha-amylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P04745, gene: AMY1A, swissprot: AMY1_HUMAN) Pancreatic alpha-amylase (Organism: Sus scrofa, class: Unclassified, accessions: P00690, gene: AMY2, swissprot: AMYP_PIG) Pancreatic alpha-amylase (Organism: Homo sapiens, class: Enzyme, accessions: P04746, gene: AMY2A, swissprot: AMYP_HUMAN) | An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE. | alpha Glucosidase Inhibitors (Code: N0000000166) alpha-Glucosidase Inhibitor (Code: N0000175559) Enzyme Inhibitors (Code: D004791) Glycoside Hydrolase Inhibitors (Code: D065089) Hypoglycemic Agents (Code: D007004) hypoglycemic agent (Code: CHEBI:35526) | 1995-09-06 FDA | 1AGM 1DED 1ESW 1GAH 1K1Y 1KXH 1LF9 1MXD 1MXG 1ULV 2ECP 2F6D 2OWC 2OWW 2QMJ 2QPU 2X2I 2XFF 2ZQ0 3AIC 3BC9 3JYR 3JZJ 3K8M 3PHA 3POC 3TOP 3W37 3WEL 3WEM 3WEN 3WEO 3ZOA 4B9Z 4BQF 4UAC 5CLT 5CSY 5HQA 5LRB 5NN8 5X7P 5X7Q 5X7R |
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| metildigoxin | Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) | A semisynthetic digitalis glycoside with the general properties of DIGOXIN but more rapid onset of action. Its cardiotonic action is prolonged by its demethylation to DIGOXIN in the liver. It has been used in the treatment of congestive heart failure (HEART FAILURE). | Anti-Arrhythmia Agents (Code: D000889) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) | |
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| zorubicin | None | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) | |
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| prednimustine | Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) | |
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| liothyronine | Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) THAP domain-containing protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9NVV9, gene: THAP1, swissprot: THAP1_HUMAN) Proliferating cell nuclear antigen (Organism: Homo sapiens, class: Unclassified, accessions: P12004, gene: PCNA, swissprot: PCNA_HUMAN) Thyroid hormone receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827, gene: THRA, swissprot: THA_HUMAN) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) Thyroid hormone receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10828, gene: THRB, swissprot: THB_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) Thyroid hormone receptor beta (Organism: Rattus norvegicus, class: Transcription factor, accessions: P18113, gene: Thrb, swissprot: THB_RAT) | A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. | l-Triiodothyronine (Code: N0000175946) Triiodothyronine (Code: N0000006165) | 1956-05-08 FDA | 1BSX 1SN5 1XZX 2H77 2H79 2PIV 2PIW 3GWS 3UVV 3VKX 4BVA 4LNW 4LNX 4ZO1 |
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| methylprednisolone suleptanate | prodrug of methylprednisolone | |
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| dimethyltubocurarinium | Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|Q15822, gene: CHRNA2|CHRNB2, swissprot: ACHA2_HUMAN|ACHB2_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) | from Chinese herb Cyclea hainanensis Mrr | Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Peripheral Nervous System Agents (Code: D018373) | None FDA | 3PEO |
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| bromocriptine | Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Cerebral cortex alpha adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130|Q28838, gene: ADRA1A|ADRA2A, swissprot: ADA1A_BOVIN|ADA2A_BOVIN) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) Vesicular glutamate transporter 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q7TSF2, gene: Slc17a8, swissprot: VGLU3_RAT) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) | A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion. | Ergolines (Code: N0000007618) Ergot Derivative (Code: N0000175827) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Neurotransmitter Agents (Code: D018377) hormone antagonist (Code: CHEBI:49020) antiparkinson drug (Code: CHEBI:48407) antidyskinesia agent (Code: CHEBI:66956) dopamine agonist (Code: CHEBI:51065) | 1978-06-28 FDA | 3UA1 5VCG |
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| nicofetamide | None | |
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| teniposide | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) Canalicular multispecific organic anion transporter 2 (Organism: Homo sapiens, class: Transporter, accessions: O15438, gene: ABCC3, swissprot: MRP3_HUMAN) Multidrug resistance-associated protein 6 (Organism: Homo sapiens, class: Transporter, accessions: O95255, gene: ABCC6, swissprot: MRP6_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. | Topoisomerase Inhibitor (Code: N0000175609) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) antineoplastic agent (Code: CHEBI:35610) | 1992-07-14 FDA | 4L9Q |
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| bisoctrizole | None | None FDA | |
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| fytic acid | Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent. | 1BQ3 1DKP 1DKQ 1HG5 1NIH 1THB 1ZSH 1ZY7 2FVV 2P1M 2P1N 2P1O 2P1P 2P1Q 2Q9P 2VGL 2XAL 2XAM 2XAR 3C6N 3C6O 3C6P 3EEB 3FZY 3GCD 3HO6 3HXN 3MMJ 3NTL 3PA8 3PEE 3PEU 3PEV 3RRM 3RRN 3T9C 3UDZ 3W8L 4AIW 4AQK 4HNW 4LV7 4O4F 4UQI 4WPC 4XNH 4Y94 5CVH 5ED1 5ED2 5HDT 5HP2 5HP3 5ICN 5IJJ 5IJP 5KLP 5KLQ 5MOE 5MPJ 5MWM 5MZA 5OQU 5ORJ 5TV1 5W3T 5W3X 5W3Y 5W40 |
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| syrosingopine | None | |
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| zinostatin | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic. | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Cytotoxins (Code: D003603) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1NCO |
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| iobenzamic acid | None | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | |
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| clindamycin palmitate | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) | 1986-04-07 FDA | |
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| natamycin | Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. | Polyene Antimicrobial (Code: N0000175936) Polyenes (Code: N0000007672) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antifungal Agents (Code: D000935) | 1978-10-30 FDA | |
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| alcuronium | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Sus scrofa, class: GPCR, accessions: P06199, gene: CHRM2, swissprot: ACM2_PIG) | A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant. | Adjuvants, Anesthesia (Code: D000759) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | 1963-01-01 YEAR INTRODUCED | |
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| etoposide phosphate | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) | Etoposide phosphate is a prodrug that is converted to its active moiety, etoposide, by dephosphorylation. Etoposide causes the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals, leading to cell cycle arrest, primarily at the G2 stage of the cell cycle, and cell death. | Antineoplastic Agents (Code: D000970) antineoplastic agent (Code: CHEBI:35610) | 1996-05-17 FDA | |
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| pentamycin | None | |
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| saquinavir | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Chloroquine resistance transporter (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q9N623, gene: CRT, swissprot: CRT_PLAFA) Protease (Organism: Human rhinovirus sp, class: Enzyme, accessions: Q4U254, gene: protease, swissprot: Q4U254_9ENTO) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A. | Protease Inhibitor (Code: N0000175889) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Metabolic Side Effects of Drugs and Substances (Code: D065606) Cytochrome P450 3A Inhibitors (Code: N0000190114) Protease Inhibitors (Code: D011480) antiviral drug (Code: CHEBI:36044) | 1995-12-06 FDA | 1C6Z 1FB7 1HXB 2NMY 2NMZ 2NNK 2NNP 3CYX 3D1X 3D1Y 3EKQ 3EL4 3K4V 3N3I 3NDT 3NDU 3OXC 3PWR 3PWW 3S56 3TKG 3TL9 3UFN 4Q5M 4QGI 5KQX 5KR2 |
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| thymopentin | Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies. | Adjuvants, Immunologic (Code: D000276) Immunologic Factors (Code: D007155) | |
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| temoporfin | used as PHOTOCHEMOTHERAPY | Antineoplastic Agents (Code: D000970) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) photosensitizing agent (Code: CHEBI:47868) | 2001-10-24 EMA | |
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| prednisolone steaglate | None | |
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| enviomycin | Cyclic basic peptide related to VIOMYCIN. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antitubercular (Code: D000904) Antitubercular Agents (Code: D000995) | |
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| viomycin | A strongly basic peptide, antibiotic complex from several strains of Streptomyces. It is allergenic and toxic to kidneys and the labyrinth. Viomycin is used in tuberculosis as several different salts and in combination with other agents. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antitubercular (Code: D000904) Antitubercular Agents (Code: D000995) Enzyme Inhibitors (Code: D004791) Protein Synthesis Inhibitors (Code: D011500) antitubercular agent (Code: CHEBI:33231) | None FDA | |
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| posaconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 14-alpha sterol demethylase (Organism: Neosartorya fumigata, class: Enzyme, accessions: Q96W81, gene: cyp51B, swissprot: Q96W81_ASPFM) 14-alpha sterol demethylase Cyp51A (Organism: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100), class: Enzyme, accessions: Q4WNT5, gene: None, swissprot: Q4WNT5_ASPFU) | an antifungal medicine that belongs to the triazole group, it works by preventing the formation of ergosterol, which is an important part of fungal cell walls | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) Trypanocidal Agents (Code: D014344) trypanocidal drug (Code: CHEBI:36335) | 2006-09-15 FDA | 2X2N 4J14 4ZE1 5FSA 5TL8 |
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| sulbutiamine | a glutamatergic, dopaminergic, and neurotropic agent which in animals improved learning ability & resistance to fatigue | |
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| atazanavir | UDP-glucuronosyltransferase 1-1 (Organism: Homo sapiens, class: Enzyme, accessions: P22309, gene: UGT1A1, swissprot: UD11_HUMAN) Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Protease (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9YQ12, gene: protease, swissprot: Q9YQ12_9HIV1) | An azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. | Protease Inhibitor (Code: N0000175889) UGT1A1 Inhibitors (Code: N0000191272) UDP Glucuronosyltransferases Inhibitors (Code: N0000191269) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Protease Inhibitors (Code: D011480) antiviral drug (Code: CHEBI:36044) | 2004-03-02 EMA 2003-06-20 FDA | 2AQU 2FXD 2FXE 2O4K 3EKW 3EKY 3EL1 3EL9 3EM4 3OXX |
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| itraconazole | Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Cruzipain (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P25779, gene: None, swissprot: CYSP_TRYCR) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) 14-alpha sterol demethylase (Organism: Neosartorya fumigata, class: Enzyme, accessions: Q96W81, gene: cyp51B, swissprot: Q96W81_ASPFM) 14-alpha sterol demethylase Cyp51A (Organism: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100), class: Enzyme, accessions: Q4WNT5, gene: None, swissprot: Q4WNT5_ASPFU) C-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P51679, gene: CCR4, swissprot: CCR4_HUMAN) C-X-C chemokine receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P25024, gene: CXCR1, swissprot: CXCR1_HUMAN) | A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. | Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) 14-alpha Demethylase Inhibitors (Code: D058888) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) | 1992-09-11 FDA | 4ZDY 4ZE2 5EQB 5ESG 5ESH 5ESK 5ESL 5JLC 5V5Z 6AYC |
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| benproperine | None | antitussive (Code: CHEBI:51177) | |
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| lucimycin | A macrolide antibiotic isolated from cultures of Streptomyces lucensis. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | |
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| bietaserpine | hypotensive agent; structure | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | |
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| talaporfin | effective tumor localizer that brings about the selective degradation of tumor tissue following light exposure; structure given in first source | Antineoplastic Agents (Code: D000970) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) | 2003-10-26 PMDA | |
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| digitalin | None | |
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| erythromycin | Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Motilin receptor (Organism: Homo sapiens, class: GPCR, accessions: O43193, gene: MLNR, swissprot: MTLR_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) | A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. | Decreased Sebaceous Gland Activity (Code: N0000009982) Macrolide (Code: N0000175877) Macrolide Antimicrobial (Code: N0000175935) Macrolides (Code: N0000007529) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Protein Synthesis Inhibitors (Code: D011500) | 1964-06-24 FDA | 1JZY 1YI2 2IYF 2J0D 3AOC 3FRQ 4M83 4V7U 4V7X 4WFN 4ZJL 4ZJO 4ZJQ 5IGP 5IGT 5IGY 5IH0 5IWU 5YK2 |
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| tretinoin tocoferil | a hybrid compound composed of alpha-tocopherol esterified with retinoic acid; RN refers to (2R*(4R*,8R*)-(+-))-isomer | |
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| ritonavir | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) | Ritonavir is a peptidomimetic inhibitor of the HIV-1 protease. Inhibition of HIV protease renders the enzyme incapable of processing the Gag-Pol polyprotein precursor which leads to production of non-infectious immature HIV particles. | Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Metabolic Side Effects of Drugs and Substances (Code: D065606) Cytochrome P450 3A Inhibitor (Code: N0000191001) Protease Inhibitor (Code: N0000175889) Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Cytochrome P450 2C19 Inducers (Code: N0000185607) Cytochrome P450 3A Inducers (Code: N0000190118) P-Glycoprotein Inhibitors (Code: N0000185503) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 1A2 Inducers (Code: N0000191266) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 2B6 Inducers (Code: N0000187064) UDP Glucuronosyltransferases Inducers (Code: N0000190117) Protease Inhibitors (Code: D011480) antiviral drug (Code: CHEBI:36044) | 1996-03-01 FDA | 1HXW 1N49 1RL8 1SH9 2B60 3NDW 3NDX 3NXU 3PRS 3Q70 3TNE 4EYR 4NJV 5VC0 5VCE 5VEU |
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| valrubicin | DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) | None | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 1998-09-25 FDA | |
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| petrichloral | None | |
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| dexchlorpheniramine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) Membrane-associated progesterone receptor component 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: P70580, gene: Pgrmc1, swissprot: PGRC1_RAT) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) | 1981-07-14 FDA | |
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| colfosceril palmitate | used in the treatment of unilateral pulmonary interstitial emphysema; component of Exosurf | 1990-08-02 FDA | 1KB9 2AZQ 2YGN 2YGO 2YGP 2YGQ |
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| glucosulfone | None | |
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| clarithromycin | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation. | Macrolide Antimicrobial (Code: N0000175935) Macrolides (Code: N0000007529) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A Inhibitors (Code: N0000190114) P-Glycoprotein Inhibitors (Code: N0000185503) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) Protein Synthesis Inhibitors (Code: D011500) antibacterial drug (Code: CHEBI:36047) | 1991-10-31 FDA | 1J5A 5IGJ 5IGW |
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| azithromycin | Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Motilin receptor (Organism: Homo sapiens, class: GPCR, accessions: O43193, gene: MLNR, swissprot: MTLR_HUMAN) | A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. | Macrolide Antimicrobial (Code: N0000175935) Macrolides (Code: N0000007529) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1991-11-01 FDA | 1M1K 1NWY 1YHQ 4V7Y 5IGI 5IGV 5UXC 5UXD |
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| ciclosporin | Peptidyl-prolyl cis-trans isomerase A (Organism: Homo sapiens, class: Enzyme, accessions: P62937, gene: PPIA, swissprot: PPIA_HUMAN) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q02127, gene: DHODH, swissprot: PYRD_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Sodium/bile acid cotransporter (Organism: Homo sapiens, class: Transporter, accessions: Q14973, gene: SLC10A1, swissprot: NTCP_HUMAN) Solute carrier organic anion transporter family member 1B3 (Organism: Homo sapiens, class: Transporter, accessions: Q9NPD5, gene: SLCO1B3, swissprot: SO1B3_HUMAN) fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Organism: Homo sapiens, class: Enzyme, accessions: Q08209, gene: PPP3CA, swissprot: PP2BA_HUMAN) Peptidyl-prolyl cis-trans isomerase D (Organism: Homo sapiens, class: Enzyme, accessions: Q08752, gene: PPID, swissprot: PPID_HUMAN) Peptidyl-prolyl cis-trans isomerase B (Organism: Homo sapiens, class: Enzyme, accessions: P23284, gene: PPIB, swissprot: PPIB_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP1B (Organism: Homo sapiens, class: Enzyme, accessions: P68106, gene: FKBP1B, swissprot: FKB1B_HUMAN) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) Peptidyl-prolyl cis-trans isomerase FKBP4 (Organism: Homo sapiens, class: Enzyme, accessions: Q02790, gene: FKBP4, swissprot: FKBP4_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Solute carrier organic anion transporter family member 1B1 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y6L6, gene: SLCO1B1, swissprot: SO1B1_HUMAN) | A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed). | Calcineurin Inhibitor Immunosuppressant (Code: N0000175457) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antirheumatic Agents (Code: D018501) Calcineurin Inhibitors (Code: D065095) Dermatologic Agents (Code: D003879) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) antirheumatic drug (Code: CHEBI:35842) dermatologic drug (Code: CHEBI:50177) immunosuppressive agent (Code: CHEBI:35705) anti-asthmatic drug (Code: CHEBI:49167) | 1983-11-14 FDA | |
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| flurithromycin | fluorine derivative of erythromycin | Enzyme Inhibitors (Code: D004791) antibacterial drug (Code: CHEBI:36047) | |
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| benzquercin | None | |
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| vindesine | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) | Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS). | Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) antineoplastic agent (Code: CHEBI:35610) | 1979-01-01 YEAR INTRODUCED | |
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| digitoxin | Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Homo sapiens, class: Transporter, accessions: P05023, gene: ATP1A1, swissprot: AT1A1_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Canis familiaris, class: Transporter, accessions: P50997, gene: ATP1A1, swissprot: AT1A1_CANFA) Sodium/potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P05023|P05026|P13637|P14415|P50993|P54709|P54710|Q13733, gene: ATP1A1|ATP1A2|ATP1A3|ATP1A4|ATP1B1|ATP1B2|ATP1B3|FXYD2, swissprot: AT1A1_HUMAN|AT1A2_HUMAN|AT1A3_HUMAN|AT1A4_HUMAN|AT1B1_HUMAN|AT1B2_HUMAN|AT1B3_HUMAN|ATNG_HUMAN) Signal transducer and activator of transcription 3 (Organism: Homo sapiens, class: Transcription factor, accessions: P40763, gene: STAT3, swissprot: STAT3_HUMAN) | A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Anti-Arrhythmia Agents (Code: D000889) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) | None FDA | |
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| iopamidol | A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1985-12-31 FDA | |
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| pentagastrin | Gastrin/cholecystokinin type B receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30553, gene: Cckbr, swissprot: GASR_RAT) Cholecystokinin receptor type A (Organism: Rattus norvegicus, class: GPCR, accessions: P30551, gene: Cckar, swissprot: CCKAR_RAT) Gastrin/cholecystokinin type B receptor (Organism: Homo sapiens, class: GPCR, accessions: P32239, gene: CCKBR, swissprot: GASR_HUMAN) Gastrin/cholecystokinin type B receptor (Organism: Mus musculus, class: GPCR, accessions: P56481, gene: Cckbr, swissprot: GASR_MOUSE) | A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. | 1974-07-26 FDA | |
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| bisbentiamine | None | |
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| erythromycin acistrate | prodrug of erythromycin; 2'-acetyl ester & stearate salt of erythromycin | |
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| levothyroxine | Thyroid hormone receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10828, gene: THRB, swissprot: THB_HUMAN) THAP domain-containing protein 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9NVV9, gene: THAP1, swissprot: THAP1_HUMAN) Thyroid hormone receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10827, gene: THRA, swissprot: THA_HUMAN) Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) | The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism. | l-Thyroxine (Code: N0000175945) Thyroxine (Code: N0000007632) | 2000-08-21 FDA | 1ETA 1ETB 1F86 1HK1 1HK2 1HK3 1HK4 1HK5 1ICT 1IE4 1SN0 1Y0X 2CEO 2RIW 2ROX 2XN6 2XN7 3OZK 3Q1E 4LNX 4X30 5CR1 |
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| iomeprol | None | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | |
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| vinorelbine | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) | None | Vinca Alkaloid (Code: N0000175612) Vinca Alkaloids (Code: N0000007780) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) photosensitizing agent (Code: CHEBI:47868) antineoplastic agent (Code: CHEBI:35610) | 1994-12-23 FDA | |
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| gitoxin | an isomer of digoxin; the OH group which is in the C16 position while it is in the C12 position for Digoxin | |
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| digoxin | Sodium/potassium-transporting ATPase subunit alpha-2 (Organism: Sus scrofa, class: Ion channel, accessions: D2WKD8, gene: ATP1A2, swissprot: AT1A2_PIG) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Sodium/potassium-transporting ATPase subunit alpha-1 (Organism: Canis familiaris, class: Transporter, accessions: P50997, gene: ATP1A1, swissprot: AT1A1_CANFA) Nuclear receptor ROR-gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P51449, gene: RORC, swissprot: RORG_HUMAN) Nuclear receptor ROR-gamma (Organism: Mus musculus, class: Unclassified, accessions: P51450, gene: Rorc, swissprot: RORG_MOUSE) Sodium/potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P05023|P05026|P13637|P14415|P50993|P54709|P54710|Q13733, gene: ATP1A1|ATP1A2|ATP1A3|ATP1A4|ATP1B1|ATP1B2|ATP1B3|FXYD2, swissprot: AT1A1_HUMAN|AT1A2_HUMAN|AT1A3_HUMAN|AT1A4_HUMAN|AT1B1_HUMAN|AT1B2_HUMAN|AT1B3_HUMAN|ATNG_HUMAN) Signal transducer and activator of transcription 3 (Organism: Homo sapiens, class: Transcription factor, accessions: P40763, gene: STAT3, swissprot: STAT3_HUMAN) | A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666) | Cardiac Glycoside (Code: N0000175568) Cardiac Glycosides (Code: N0000008157) Anti-Arrhythmia Agents (Code: D000889) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protective Agents (Code: D020011) anti-arrhythmia drug (Code: CHEBI:38070) cardiotonic drug (Code: CHEBI:38147) | 1975-10-24 FDA | 1IGJ 3B0W 4RET |
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| rifaximin | Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Bacterial DNA-directed RNA polymerase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A7Z4|P0A800|P0A8T7|P0A8V2, gene: rpoA|rpoB|rpoC|rpoZ, swissprot: RPOA_ECOLI|RPOB_ECOLI|RPOC_ECOLI|RPOZ_ECOLI) | None | Rifamycin Antibacterial (Code: N0000175500) Rifamycins (Code: N0000007911) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Nucleic Acid Synthesis Inhibitors (Code: D019384) orphan drug (Code: CHEBI:71031) gastrointestinal drug (Code: CHEBI:55324) | 2004-05-25 FDA | |
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| canfosfamide | a glutathione-based glutathione S-transferase-activated cytotoxin; TLK-286 is the ((R)-(-))-isomer | |
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| meradimate | None | None FDA | |
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| estradiol mustard | Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211, gene: Esr1, swissprot: ESR1_RAT) | None | |
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| metrizamide | A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1978-08-23 FDA | |
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| erythromycin propionate | Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) | A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Protein Synthesis Inhibitors (Code: D011500) | |
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| ioxilan | None | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1995-12-21 FDA | |
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| iopromide | None | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1995-05-10 FDA | |
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| anhydrovinblastine | Tubulin beta-4B chain (Organism: Homo sapiens, class: Structural, accessions: P68371, gene: TUBB4B, swissprot: TBB4B_HUMAN) Multidrug resistance-associated protein 7 (Organism: Homo sapiens, class: Transporter, accessions: Q5T3U5, gene: ABCC10, swissprot: MRP7_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | None | 1965-01-01 YEAR INTRODUCED | |
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| bisdequalinium chloride | None | |
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| tacrolimus | Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (Organism: Homo sapiens, class: Enzyme, accessions: P48454, gene: PPP3CC, swissprot: PP2BC_HUMAN) Interleukin-2 (Organism: Homo sapiens, class: Cytokine, accessions: P60568, gene: IL2, swissprot: IL2_HUMAN) Interferon gamma (Organism: Homo sapiens, class: Cytokine, accessions: P01579, gene: IFNG, swissprot: IFNG_HUMAN) Interleukin-5 (Organism: Homo sapiens, class: Cytokine, accessions: P05113, gene: IL5, swissprot: IL5_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP10 (Organism: Homo sapiens, class: Enzyme, accessions: Q96AY3, gene: FKBP10, swissprot: FKB10_HUMAN) Serine/threonine-protein kinase mTOR (Organism: Homo sapiens, class: Kinase, accessions: P42345, gene: MTOR, swissprot: MTOR_HUMAN) Splicing factor 3B subunit 3 (Organism: Homo sapiens, class: Unclassified, accessions: Q15393, gene: SF3B3, swissprot: SF3B3_HUMAN) Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Organism: Homo sapiens, class: Enzyme, accessions: Q08209, gene: PPP3CA, swissprot: PP2BA_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP5 (Organism: Homo sapiens, class: Enzyme, accessions: Q13451, gene: FKBP5, swissprot: FKBP5_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP1B (Organism: Homo sapiens, class: Enzyme, accessions: P68106, gene: FKBP1B, swissprot: FKB1B_HUMAN) | A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. | Calcineurin Inhibitor Immunosuppressant (Code: N0000175457) Calcineurin Inhibitors (Code: D065095) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) immunosuppressive agent (Code: CHEBI:35705) | 1994-04-08 FDA | |
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| solasulfone | used in drug therapy of leprosy; structure | |
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| acetyldigitoxin | Sodium/potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P05023|P05026|P13637|P14415|P50993|P54709|P54710|Q13733, gene: ATP1A1|ATP1A2|ATP1A3|ATP1A4|ATP1B1|ATP1B2|ATP1B3|FXYD2, swissprot: AT1A1_HUMAN|AT1A2_HUMAN|AT1A3_HUMAN|AT1A4_HUMAN|AT1B1_HUMAN|AT1B2_HUMAN|AT1B3_HUMAN|ATNG_HUMAN) | Cardioactive derivatives of lanatoside A or of DIGITOXIN. They are used for fast digitalization in congestive heart failure. | anti-arrhythmia drug (Code: CHEBI:38070) cardiotonic drug (Code: CHEBI:38147) | 1975-04-24 FDA | |
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| ioversol | None | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1988-12-30 FDA | |
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| apatinib | Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) | Apatinib is an oral tyrosine kinase inhibitor approved in China for the treatment of patients with advanced metastatic gastric cancer. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) | None China Food and Drug Administration (CFDA) | |
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| docetaxel | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Multidrug resistance-associated protein 7 (Organism: Homo sapiens, class: Transporter, accessions: Q5T3U5, gene: ABCC10, swissprot: MRP7_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Growth hormone-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q02643, gene: GHRHR, swissprot: GHRHR_HUMAN) | semisynthetic analog of taxol | Microtubule Inhibition (Code: N0000175085) Microtubule Inhibitor (Code: N0000175592) Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) antimalarial (Code: CHEBI:38068) | 1996-05-14 FDA | |
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| pimecrolimus | Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (Organism: Homo sapiens, class: Enzyme, accessions: P48454, gene: PPP3CC, swissprot: PP2BC_HUMAN) Interleukin-2 (Organism: Homo sapiens, class: Cytokine, accessions: P60568, gene: IL2, swissprot: IL2_HUMAN) Interferon gamma (Organism: Homo sapiens, class: Cytokine, accessions: P01579, gene: IFNG, swissprot: IFNG_HUMAN) Interleukin-5 (Organism: Homo sapiens, class: Cytokine, accessions: P05113, gene: IL5, swissprot: IL5_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62658, gene: Fkbp1a, swissprot: FKB1A_RAT) | an ascomycin derivative; mechanism of action involves calcineurin inhibition, blockage of T cell activation, blocking signal transduction pathways in T cells, and inhibition of the synthesis of inflammatory cytokines, specifically Th1- and Th2-type cytokines | Calcineurin Inhibitor Immunosuppressant (Code: N0000175457) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Calcineurin Inhibitors (Code: D065095) Dermatologic Agents (Code: D003879) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2001-12-13 FDA | |
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| inositol nicotinate | None | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | None FDA | |
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| vinblastine | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) Thromboxane-A synthase (Organism: Homo sapiens, class: Enzyme, accessions: P24557, gene: TBXAS1, swissprot: THAS_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Multidrug resistance-associated protein 7 (Organism: Homo sapiens, class: Transporter, accessions: Q5T3U5, gene: ABCC10, swissprot: MRP7_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Amine oxidase [flavin-containing] B (Organism: Bos taurus, class: Enzyme, accessions: P56560, gene: MAOB, swissprot: AOFB_BOVIN) | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Vinca Alkaloid (Code: N0000175612) Vinca Alkaloids (Code: N0000007780) Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) | 1965-11-05 FDA | |
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| aclarubicin | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) | An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity. | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | |
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| telithromycin | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | a ketolide; semisynthetic derivative of erythromycin with cycling of the C11-12 positions to form a carbamate ring to avoid acquired resistance to macrolides; binds 70S bacterial rRNA, specifically to the 23S part (23S RIBOSOMAL RNA), preventing protein synthesis | Ketolide Antibacterial (Code: N0000175492) Ketolides (Code: N0000011414) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 2004-04-01 FDA | |
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| sorbinicate | None | |
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| troleandomycin | A macrolide antibiotic that is similar to ERYTHROMYCIN. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1969-05-27 FDA | |
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| delafloxacin | Delafloxacin belongs to the fluoroquinolone class of antibacterial drugs and is anionic in nature. The antibacterial activity of delafloxacin is due to the inhibition of both bacterial topoisomerase IV and DNA gyrase (topoisomerase II) enzymes which are required for bacterial DNA replication, transcription, repair, and recombination. Delafloxacin exhibits a concentration-dependent bactericidal activity against gram-positive and gram-negative bacteria in vitro. | Anti-Infective Agents (Code: D000890) Fluoroquinolone Antibacterial (Code: N0000193223) Fluoroquinolones (Code: N0000011190) | 2017-06-19 FDA | |
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| mydecamycin | macrolide antibiotic from Streptomyces hygroscopicus JA 6599; structure | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| vinflunine | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) | inhibits tubulin assembly | antineoplastic agent (Code: CHEBI:35610) | |
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| cystine | A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine. | |
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| pralmorelin | Growth hormone secretagogue receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: Q92847, gene: GHSR, swissprot: GHSR_HUMAN) Growth hormone secretagogue receptor type 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: O08725, gene: Ghsr, swissprot: GHSR_RAT) | None | 2004-10-22 PMDA | |
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| evogliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) | Evogliptin is an orally bioavailable, selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus. DPP-4 inhibitors control glucose levels by preventing the breakdown of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), which stimulate insulin secretion in response to the increased levels of glucose in the period following meals. | 2015-10-02 Korean Food and Drug Administration (KFDA) | |
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| etiroxate | None | Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | |
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| iohexol | An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1985-12-26 FDA | |
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| glycyrrhizic acid | Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Homo sapiens, class: Enzyme, accessions: P28845, gene: HSD11B1, swissprot: DHI1_HUMAN) Corticosteroid 11-beta-dehydrogenase isozyme 1 (Organism: Mus musculus, class: Enzyme, accessions: P50172, gene: Hsd11b1, swissprot: DHI1_MOUSE) Corticosteroid 11-beta-dehydrogenase isozyme 2 (Organism: Homo sapiens, class: Enzyme, accessions: P80365, gene: HSD11B2, swissprot: DHI2_HUMAN) | A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system. | Anti-Inflammatory Agents (Code: D000893) | None FDA | |
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| rifampicin | DNA-directed RNA polymerase subunit beta (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A8V2, gene: rpoB, swissprot: RPOB_ECOLI) Caspase-1 (Organism: Homo sapiens, class: Enzyme, accessions: P29466, gene: CASP1, swissprot: CASP1_HUMAN) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) Solute carrier organic anion transporter family member 1B3 (Organism: Homo sapiens, class: Transporter, accessions: Q9NPD5, gene: SLCO1B3, swissprot: SO1B3_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Lanosterol 14-alpha demethylase (Organism: Homo sapiens, class: Enzyme, accessions: Q16850, gene: CYP51A1, swissprot: CP51A_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGR1, gene: inhA, swissprot: INHA_MYCTU) Solute carrier organic anion transporter family member 1A2 (Organism: Homo sapiens, class: Unclassified, accessions: P46721, gene: SLCO1A2, swissprot: SO1A2_HUMAN) Solute carrier organic anion transporter family member 1B1 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y6L6, gene: SLCO1B1, swissprot: SO1B1_HUMAN) | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) | Rifamycin Antibacterial (Code: N0000175500) Rifamycins (Code: N0000007911) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antitubercular (Code: D000904) Antitubercular Agents (Code: D000995) Cytochrome P-450 CYP2B6 Inducers (Code: D065695) Cytochrome P-450 CYP2C19 Inducers (Code: D065697) Cytochrome P-450 CYP2C8 Inducers (Code: D065696) Cytochrome P-450 CYP2C9 Inducers (Code: D065698) Cytochrome P-450 CYP3A Inducers (Code: D065701) Enzyme Inhibitors (Code: D004791) Leprostatic Agents (Code: D007917) Metabolic Side Effects of Drugs and Substances (Code: D065606) Nucleic Acid Synthesis Inhibitors (Code: D019384) | 1971-05-21 FDA | 1I6V 1SKX 1YNN 2HW2 3AOB 3AOD 4KMU 5HV1 5KOX 5UAC 5UAH 5UAL 5UH6 5UHB 5UHC 5UHD 5UHG 6BRD |
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| polmacoxib | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It is a selective COX-2 inhibitor. | 2015-02-05 Korean Food and Drug Administration (KFDA) | 5GMM 5GMN |
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| betrixaban | Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) | Betrixaban is an oral FXa inhibitor that selectively blocks the active site of FXa and does not require a cofactor (such as Anti-thrombin III) for activity. Betrixaban inhibits free FXa and prothrombinase activity. By directly inhibiting FXa, betrixaban decreases thrombin generation. Betrixaban has no direct effect on platelet aggregation. | Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Factor Xa Inhibitors (Code: D065427) Hematologic Agents (Code: D006401) Factor Xa Inhibitor (Code: N0000175637) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) | 2017-06-23 FDA | |
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| acetyldigoxin | Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure. | |
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| vincristine | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) Multidrug resistance-associated protein 7 (Organism: Homo sapiens, class: Transporter, accessions: Q5T3U5, gene: ABCC10, swissprot: MRP7_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Canalicular multispecific organic anion transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q92887, gene: ABCC2, swissprot: MRP2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Tubulin (Organism: Bos taurus, class: Structural, accessions: Q6B856|Q862F3|Q862L2, gene: TUBB2B, swissprot: Q862F3_BOVIN|Q862L2_BOVIN|TBB2B_BOVIN) | An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.) | Vinca Alkaloid (Code: N0000175612) Vinca Alkaloids (Code: N0000007780) Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) | 1963-07-10 FDA | |
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| rokitamycin | None | |
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| josamycin | A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | |
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| eptifibatide | Integrin alpha-IIb/beta-3 (Organism: Homo sapiens, class: Adhesion, accessions: P05106|P08514, gene: ITGA2B|ITGB3, swissprot: ITA2B_HUMAN|ITB3_HUMAN) | used in clinical studies as a platelet glycoprotein IIB/IIIA antagonist | Decreased Platelet Aggregation (Code: N0000008832) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) platelet aggregation inhibitor (Code: CHEBI:50427) anticoagulant (Code: CHEBI:50249) | 1998-05-18 FDA | |
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| dirithromycin | None | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) prodrug (Code: CHEBI:50266) | 1995-06-19 FDA | |
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| iopentol | None | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | |
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| iobitridol | a nonionic monomeric low-osmolality contrast medium; structure given in second source | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | |
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| roxithromycin | 50S ribosomal protein L10 (Organism: Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809), class: Ribosomal protein, accessions: P15825, gene: rpl10, swissprot: RL10_HALMA) Motilin receptor (Organism: Homo sapiens, class: GPCR, accessions: O43193, gene: MLNR, swissprot: MTLR_HUMAN) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) | Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1987-01-01 YEAR INTRODUCED | 1JZZ |
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| Spiramycin I | None | antibacterial drug (Code: CHEBI:36047) | 1KD1 5IGZ |
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| dodeclonium bromide | None | |
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| proglumetacin | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) prodrug (Code: CHEBI:50266) | |
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| rifabutin | DNA-directed RNA polymerase subunit beta (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGY9, gene: rpoB, swissprot: RPOB_MYCTU) Bacterial DNA-directed RNA polymerase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A7Z4|P0A800|P0A8T7|P0A8V2, gene: rpoA|rpoB|rpoC|rpoZ, swissprot: RPOA_ECOLI|RPOB_ECOLI|RPOC_ECOLI|RPOZ_ECOLI) | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Rifamycin Antimycobacterial (Code: N0000175501) Rifamycins (Code: N0000007911) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antitubercular (Code: D000904) Antitubercular Agents (Code: D000995) antitubercular agent (Code: CHEBI:33231) | 1992-12-23 FDA | |
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| paclitaxel | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Cholecystokinin receptor type A (Organism: Homo sapiens, class: GPCR, accessions: P32238, gene: CCKAR, swissprot: CCKAR_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) Multidrug resistance-associated protein 7 (Organism: Homo sapiens, class: Transporter, accessions: Q5T3U5, gene: ABCC10, swissprot: MRP7_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Tubulin beta chain (Organism: Homo sapiens, class: Structural, accessions: P07437, gene: TUBB, swissprot: TBB5_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Botulinum neurotoxin type A (Organism: Clostridium botulinum, class: Enzyme, accessions: P10845, gene: botA, swissprot: BXA1_CLOBO) Tubulin beta-3 chain (Organism: Homo sapiens, class: Structural, accessions: Q13509, gene: TUBB3, swissprot: TBB3_HUMAN) | A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death. | Microtubule Inhibition (Code: N0000175085) Microtubule Inhibitor (Code: N0000175592) Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) antineoplastic agent (Code: CHEBI:35610) | 1992-12-29 FDA | |
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| erythromycin ethyl succinate | A macrolide antibiotic, produced by Streptomyces erythreus. This compound is an ester of erythromycin base and succinic acid. It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Protein Synthesis Inhibitors (Code: D011500) | 1965-04-02 FDA | |
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| evans blue | Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) Tyrosine-protein phosphatase 1 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P25044, gene: PTP1, swissprot: PTP1_YEAST) Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q13822, gene: ENPP2, swissprot: ENPP2_HUMAN) Vesicular glutamate transporter 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q7TSF2, gene: Slc17a8, swissprot: VGLU3_RAT) | An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly. | Coloring Agents (Code: D004396) histological dye (Code: CHEBI:77178) fluorochrome (Code: CHEBI:51217) | None FDA | |
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| rifapentine | Bacterial DNA-directed RNA polymerase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A7Z4|P0A800|P0A8T7|P0A8V2, gene: rpoA|rpoB|rpoC|rpoZ, swissprot: RPOA_ECOLI|RPOB_ECOLI|RPOC_ECOLI|RPOZ_ECOLI) | cyclopentyl derivative of rifampicin | Rifamycin Antimycobacterial (Code: N0000175501) Rifamycins (Code: N0000007911) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antitubercular (Code: D000904) Antitubercular Agents (Code: D000995) Leprostatic Agents (Code: D007917) antitubercular agent (Code: CHEBI:33231) leprostatic drug (Code: CHEBI:35816) | 1998-06-22 FDA | 2A69 |
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| Spiramycin II | None | antibacterial drug (Code: CHEBI:36047) | |
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| romurtide | a synthetic muramyl dipeptide analog; stimulates chemotactic mobility, phagocytic activity & superoxide production by neutrophils in mice; used for the prophylaxis of leukocytopenia during radiation therapy; structure given in first source | Adjuvants, Immunologic (Code: D000276) Immunologic Factors (Code: D007155) | |
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| miocamycin | A macrolide antibiotic that has a wide antimicrobial spectrum and is particularly effective in respiratory and genital infections. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | |
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| ioglycamic acid | A radiopaque medium. It is a mixture of its meglumine and sodium salts and is used to visualize the biliary tract. | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | |
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| Spiramycin III | None | |
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| saralasin | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) Type-2 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P50052, gene: AGTR2, swissprot: AGTR2_HUMAN) Angiotensin II receptor (AT-1) type-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25095|P29089, gene: Agtr1|Agtr1b, swissprot: AGTRA_RAT|AGTRB_RAT) Type-2 angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P35351, gene: Agtr2, swissprot: AGTR2_RAT) | An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION. | Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) | None FDA | |
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| sirolimus | Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Sodium/nucleoside cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: O00337, gene: SLC28A1, swissprot: S28A1_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP3 (Organism: Homo sapiens, class: Enzyme, accessions: Q00688, gene: FKBP3, swissprot: FKBP3_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Serine/threonine-protein kinase mTOR (Organism: Homo sapiens, class: Kinase, accessions: P42345, gene: MTOR, swissprot: MTOR_HUMAN) Eukaryotic translation initiation factor 4E (Organism: Homo sapiens, class: Nuclear other, accessions: P06730, gene: EIF4E, swissprot: IF4E_HUMAN) Programmed cell death protein 4 (Organism: Homo sapiens, class: Unclassified, accessions: Q53EL6, gene: PDCD4, swissprot: PDCD4_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP5 (Organism: Homo sapiens, class: Enzyme, accessions: Q13451, gene: FKBP5, swissprot: FKBP5_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP1B (Organism: Homo sapiens, class: Enzyme, accessions: P68106, gene: FKBP1B, swissprot: FKB1B_HUMAN) | A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. | Decreased Immunologic Activity (Code: N0000175550) mTOR Inhibitor Immunosuppressant (Code: N0000175625) mTOR Inhibitors (Code: N0000175624) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antineoplastic (Code: D000903) Antifungal Agents (Code: D000935) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) immunosuppressive agent (Code: CHEBI:35705) antineoplastic agent (Code: CHEBI:35610) antibacterial drug (Code: CHEBI:36047) | 1999-09-15 FDA | 1C9H 1FAP 1FKB 1FKL 1PBK 1Z58 2DG3 2DG4 2DG9 3KZ7 4DRH 4DRI 4DRJ 4QT2 4QT3 5GPG 5HKG |
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| cargutocin | None | |
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| ceruletide | Cholecystokinin receptor type A (Organism: Homo sapiens, class: GPCR, accessions: P32238, gene: CCKAR, swissprot: CCKAR_HUMAN) | A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. | diagnostic agent (Code: CHEBI:33295) gastrointestinal drug (Code: CHEBI:55324) | None FDA | |
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| gitoformate | None | |
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| amphotericin B | Ergosterol (Organism: None, class: Metabolite, accessions: None, gene: None, swissprot: None) | Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela. | Lipid-based Polyene Antifungal (Code: N0000175510) Polyene Antifungal (Code: N0000175498) Polyenes (Code: N0000007672) Amebicides (Code: D000563) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antiprotozoal drug (Code: CHEBI:35820) | 1964-11-12 FDA | |
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| nystatin | Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3. | Polyene Antifungal (Code: N0000175498) Polyenes (Code: N0000007672) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Ionophores (Code: D007476) Membrane Transport Modulators (Code: D049990) | 1964-07-08 FDA | |
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| cisatracurium | Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) | None | Neuromuscular Nondepolarizing Blockade (Code: N0000175732) Nondepolarizing Neuromuscular Blocker (Code: N0000175720) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Peripheral Nervous System Agents (Code: D018373) muscle relaxant (Code: CHEBI:51371) nicotinic antagonist (Code: CHEBI:48878) | 1995-12-15 FDA | |
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| atracurium | Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Small conductance calcium-activated potassium channel protein 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P70605, gene: Kcnn3, swissprot: KCNN3_RAT) | A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents. | Neuromuscular Nondepolarizing Blockade (Code: N0000175732) Nondepolarizing Neuromuscular Blocker (Code: N0000175720) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) muscle relaxant (Code: CHEBI:51371) nicotinic antagonist (Code: CHEBI:48878) | 1983-11-23 FDA | |
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| cangrelor | P2Y purinoceptor 12 (Organism: Homo sapiens, class: GPCR, accessions: Q9H244, gene: P2RY12, swissprot: P2Y12_HUMAN) P2Y purinoceptor 13 (Organism: Homo sapiens, class: GPCR, accessions: Q9BPV8, gene: P2RY13, swissprot: P2Y13_HUMAN) Uracil nucleotide/cysteinyl leukotriene receptor (Organism: Mus musculus, class: Unclassified, accessions: Q6NS65, gene: Gpr17, swissprot: GPR17_MOUSE) | Cangrelor is a direct P2Y12 platelet receptor inhibitor that blocks ADP-induced platelet activation and aggregation. Cangrelor binds selectively and reversibly to the P2Y12 receptor to prevent further signaling and platelet activation. | P2Y12 Platelet Inhibitor (Code: N0000182142) Decreased Platelet Aggregation (Code: N0000008832) P2Y12 Receptor Antagonists (Code: N0000182143) Hematologic Agents (Code: D006401) Neurotransmitter Agents (Code: D018377) Platelet Aggregation Inhibitors (Code: D010975) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P2 Receptor Antagonists (Code: D058919) Purinergic P2Y Receptor Antagonists (Code: D058921) platelet aggregation inhibitor (Code: CHEBI:50427) | 2015-06-22 FDA 2015-03-23 EMA | |
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| oxytocin | Oxytocin-neurophysin 1 (Organism: Homo sapiens, class: Secreted, accessions: P01178, gene: OXT, swissprot: NEU1_HUMAN) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1b receptor (Organism: Homo sapiens, class: GPCR, accessions: P47901, gene: AVPR1B, swissprot: V1BR_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Vasopressin V2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q00788, gene: Avpr2, swissprot: V2R_RAT) Oxytocin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30559, gene: OXTR, swissprot: OXYR_HUMAN) Oxytocin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P70536, gene: Oxtr, swissprot: OXYR_RAT) Vasopressin V1a receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560, gene: Avpr1a, swissprot: V1AR_RAT) | A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION. | Increased Uterine Smooth Muscle Contraction or Tone (Code: N0000009705) Oxytocin (Code: N0000006473) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) oxytocic (Code: CHEBI:36063) vasodilator agent (Code: CHEBI:35620) | 1980-04-17 FDA | |
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| demoxytocin | Oxytocin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P70536, gene: Oxtr, swissprot: OXYR_RAT) | octa-peptide lacking free amino group on cystine residue; RN given refers to cpd without isomeric designation | Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102) | |
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| octreotide | Somatostatin receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P35346, gene: SSTR5, swissprot: SSR5_HUMAN) Somatostatin receptor type 3 (Organism: Homo sapiens, class: GPCR, accessions: P32745, gene: SSTR3, swissprot: SSR3_HUMAN) Somatostatin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P30874, gene: SSTR2, swissprot: SSR2_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Somatostatin receptor type 5 (Organism: Rattus norvegicus, class: GPCR, accessions: P30938, gene: Sstr5, swissprot: SSR5_RAT) Somatostatin receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P30872, gene: SSTR1, swissprot: SSR1_HUMAN) Somatostatin receptor type 3 (Organism: Mus musculus, class: GPCR, accessions: P30935, gene: Sstr3, swissprot: SSR3_MOUSE) Somatostatin receptor type 2 (Organism: Mus musculus, class: GPCR, accessions: P30875, gene: Sstr2, swissprot: SSR2_MOUSE) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) Somatostatin receptor type 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P30680, gene: Sstr2, swissprot: SSR2_RAT) Somatostatin receptor type 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: P30936, gene: Sstr3, swissprot: SSR3_RAT) | A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula. | Somatostatin Analog (Code: N0000175904) Somatostatin Receptor Agonists (Code: N0000000194) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Gastrointestinal Agents (Code: D005765) hormone agonist (Code: CHEBI:51060) | 1988-10-21 FDA | |
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| quinupristin | component of RP 59500 | Streptogramin Antibacterial (Code: N0000175502) Streptogramins (Code: N0000011418) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1999-09-21 FDA | |
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| mivacurium | Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) | a short-acting nondepolarizing agent; RN from Toxlit 6/88 | Neuromuscular Agents (Code: D009465) Neuromuscular Blocking Agents (Code: D009466) Neuromuscular Nondepolarizing Agents (Code: D003473) Peripheral Nervous System Agents (Code: D018373) | 1992-01-22 FDA | |
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| sonidegib | Smoothened homolog (Organism: Homo sapiens, class: GPCR, accessions: Q99835, gene: SMO, swissprot: SMO_HUMAN) Sonic hedgehog protein (Organism: Mus musculus, class: Enzyme, accessions: Q62226, gene: Shh, swissprot: SHH_MOUSE) | specific Smoothened/Smo antagonist | Hedgehog Pathway Inhibitor (Code: N0000184149) Smoothened Receptor Antagonists (Code: N0000184148) antineoplastic agent (Code: CHEBI:35610) | 2015-07-24 FDA 2015-06-25 EMA | |
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| lumacaftor | Cystic fibrosis transmembrane conductance regulator (Organism: Homo sapiens, class: Ion channel, accessions: P13569, gene: CFTR, swissprot: CFTR_HUMAN) | Lumacaftor improves the conformational stability of F508del-CFTR, resulting in increased processing and trafficking of mature protein to the cell surface. | Cystic Fibrosis Transmembrane Conductance Regulator Potentiator (Code: N0000184146) Chloride Channel Activation Potentiators (Code: N0000184145) Cytochrome P450 3A Inducers (Code: N0000190118) Cytochrome P450 2B6 Inducers (Code: N0000187064) Cytochrome P450 2C8 Inducers (Code: N0000187063) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 2C19 Inducers (Code: N0000185607) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) orphan drug (Code: CHEBI:71031) | 2015-07-02 FDA | |
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| desmopressin | Oxytocin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30559, gene: OXTR, swissprot: OXYR_HUMAN) Vasopressin V1b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P48974, gene: Avpr1b, swissprot: V1BR_RAT) Vasopressin V2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q00788, gene: Avpr2, swissprot: V2R_RAT) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Vasopressin V1b receptor (Organism: Homo sapiens, class: GPCR, accessions: P47901, gene: AVPR1B, swissprot: V1BR_HUMAN) Vasopressin V1a receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560, gene: Avpr1a, swissprot: V1AR_RAT) Oxytocin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P70536, gene: Oxtr, swissprot: OXYR_RAT) | A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR. | Factor VIII Activator (Code: N0000175916) Increased Coagulation Factor VIII Activity (Code: N0000175914) Increased Coagulation Factor VIII Concentration (Code: N0000175915) Vasopressin Analog (Code: N0000175905) Vasopressins (Code: N0000006320) vasopressin receptor agonist (Code: CHEBI:59727) renal agent (Code: CHEBI:35846) diagnostic agent (Code: CHEBI:33295) | 1978-02-21 FDA | |
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| vasopressin | Vasopressin V2 receptor (Organism: Sus scrofa, class: GPCR, accessions: P32307, gene: AVPR2, swissprot: V2R_PIG) Vasopressin V2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q00788, gene: Avpr2, swissprot: V2R_RAT) Oxytocin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30559, gene: OXTR, swissprot: OXYR_HUMAN) Vasopressin V2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518, gene: AVPR2, swissprot: V2R_HUMAN) Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) Vasopressin V1b receptor (Organism: Homo sapiens, class: GPCR, accessions: P47901, gene: AVPR1B, swissprot: V1BR_HUMAN) Vasopressin V2 receptor (Organism: Bos taurus, class: GPCR, accessions: P48044, gene: AVPR2, swissprot: V2R_BOVIN) Vasopressin V1b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P48974, gene: Avpr1b, swissprot: V1BR_RAT) Vasopressin V1a receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560, gene: Avpr1a, swissprot: V1AR_RAT) Vasopressin V1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30560|P48974, gene: Avpr1a|Avpr1b, swissprot: V1AR_RAT|V1BR_RAT) Oxytocin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P70536, gene: Oxtr, swissprot: OXYR_RAT) | None | Antidiuretic Agents (Code: D050034) Cardiovascular Agents (Code: D002317) Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Natriuretic Agents (Code: D045283) Vasoconstrictor Agents (Code: D014662) | None FDA | |
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| plicamycin | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies. | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Coloring Agents (Code: D004396) Enzyme Inhibitors (Code: D004791) Fluorescent Dyes (Code: D005456) Indicators and Reagents (Code: D007202) Luminescent Agents (Code: D049408) Nucleic Acid Synthesis Inhibitors (Code: D019384) Protein Synthesis Inhibitors (Code: D011500) antineoplastic agent (Code: CHEBI:35610) | 1970-05-05 FDA | |
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| lypressin | Vasopressin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30518|P37288|P47901, gene: AVPR1A|AVPR1B|AVPR2, swissprot: V1AR_HUMAN|V1BR_HUMAN|V2R_HUMAN) | The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE. | Antidiuretic Agents (Code: D050034) Cardiovascular Agents (Code: D002317) Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Natriuretic Agents (Code: D045283) Vasoconstrictor Agents (Code: D014662) | None FDA | |
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| lanreotide | Somatostatin receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P30872, gene: SSTR1, swissprot: SSR1_HUMAN) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) Somatostatin receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P35346, gene: SSTR5, swissprot: SSR5_HUMAN) Somatostatin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P30874, gene: SSTR2, swissprot: SSR2_HUMAN) Somatostatin receptor type 3 (Organism: Homo sapiens, class: GPCR, accessions: P32745, gene: SSTR3, swissprot: SSR3_HUMAN) Somatostatin receptor type 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P30680, gene: Sstr2, swissprot: SSR2_RAT) Somatostatin receptor type 3 (Organism: Mus musculus, class: GPCR, accessions: P30935, gene: Sstr3, swissprot: SSR3_MOUSE) Somatostatin receptor type 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: P30936, gene: Sstr3, swissprot: SSR3_RAT) Somatostatin receptor type 5 (Organism: Rattus norvegicus, class: GPCR, accessions: P30938, gene: Sstr5, swissprot: SSR5_RAT) | synthetic octapeptide analog of somatostatin; inhibits accelerated transplant atherosclerosis in rabbit heart arteries | Somatostatin Analog (Code: N0000175904) Somatostatin Receptor Agonists (Code: N0000000194) Antineoplastic Agents (Code: D000970) Cardiovascular Agents (Code: D002317) | 2007-08-30 FDA | |
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| caspofungin | Beta-1,3-glucan synthase catalytic subunit 1 (Organism: Candida albicans, class: Enzyme, accessions: O13428, gene: GSC1, swissprot: O13428_CANAX) 1,3-beta-glucan synthase catalytic subunit FksP (Organism: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100), class: Enzyme, accessions: Q4WLT4, gene: None, swissprot: Q4WLT4_ASPFU) | Caspofungin, an echinocandin, inhibits the synthesis of beta (1,3)-D-glucan, an essential component of the cell wall of susceptible Aspergillus species and Candida species. Beta (1,3)-D-glucan is not present in mammalian cells. Caspofungin has shown activity against Candida species and in regions of active cell growth of the hyphae of Aspergillus fumigatus. | Echinocandin Antifungal (Code: N0000175507) Lipopeptides (Code: N0000175508) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) antiinfective agent (Code: CHEBI:35441) | 2001-01-26 FDA | |
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| adipiodone | A water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1954-04-27 FDA | 2BXN |
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| dapagliflozin | Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) Low affinity sodium-glucose cotransporter (Organism: Homo sapiens, class: Transporter, accessions: Q9NY91, gene: SLC5A4, swissprot: SC5A4_HUMAN) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) Sodium/myo-inositol cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: Q8WWX8, gene: SLC5A11, swissprot: SC5AB_HUMAN) Sodium/glucose cotransporter 2 (Organism: Rattus norvegicus, class: Transporter, accessions: P53792, gene: Slc5a2, swissprot: SC5A2_RAT) | an Sodium-glucose cotransporter 2 (SGLT2) inhibitor, SGLT2 expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen, by inhibiting SGLT2, dapagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion | Sodium-Glucose Cotransporter 2 Inhibitor (Code: N0000187059) Sodium-Glucose Transporter 2 Inhibitors (Code: N0000187058) hypoglycemic agent (Code: CHEBI:35526) | 2014-01-08 FDA 2012-11-12 EMA | |
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| gonadorelin | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) Gonadotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30969, gene: Gnrhr, swissprot: GNRHR_RAT) Lutropin-choriogonadotropic hormone receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P16235, gene: Lhcgr, swissprot: LSHR_RAT) | A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND. | gonadotropin releasing hormone agonist (Code: CHEBI:63533) | 1982-09-30 FDA | |
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| eledoisin | Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) Neuromedin-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P29371, gene: TACR3, swissprot: NK3R_HUMAN) | A peptide extracted from the posterior salivary glands of certain small octopi (Eledone spp., Mollusca), or obtained by synthesis. Its actions resemble those of SUBSTANCE P; it is a potent vasodilator and increases capillary permeability. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1364) | Neurotransmitter Agents (Code: D018377) | |
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| leuprorelin | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) Gonadotropin-releasing hormone receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30969, gene: Gnrhr, swissprot: GNRHR_RAT) | A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. | Gonadotropin Releasing Hormone Receptor Agonist (Code: N0000175655) Gonadotropin Releasing Hormone Receptor Agonists (Code: N0000175654) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Fertility Agents (Code: D005299) Fertility Agents, Female (Code: D005300) Reproductive Control Agents (Code: D012102) antineoplastic agent (Code: CHEBI:35610) gonadotropin releasing hormone agonist (Code: CHEBI:63533) | 1985-04-09 FDA | |
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| iotroxic acid | Contrast media for intravenous cholecystography | |
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| terlipressin | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662) | |
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| mifamurtide | Nucleotide-binding oligomerization domain-containing protein 2 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9HC29, gene: NOD2, swissprot: NOD2_HUMAN) | Mifamurtide (muramyl tripeptide phosphatidyl ethanolamine, MTP-PE) is a fully synthetic derivative of muramyl dipeptide (MDP), the smallest naturally-occurring immune stimulatory component of cell walls from Mycobacterium sp. It has similar immunostimulatory effects as natural MDP with the additional advantage of a longer half-life in plasma. Mifamurtide liposomal formulation is specifically designed for in vivo targeting to macrophages by intravenous infusion. MTP-PE is a specific ligand of NOD2, a receptor found primarily on monocytes, dendritic cells and macrophages. MTP-PE is a potent activator of monocytes and macrophages. Activation of human macrophages by mifamurtide is associated with production of cytokines, including tumour necrosis factor (TNF-alfa), interleukin-1 (IL-1beta), IL-6, IL-8, and IL-12 and adhesion molecules, including lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1). In vitro-treated human monocytes killed allogeneic and autologous tumour cells (including melanoma, ovarian, colon, and renal carcinoma), but had no toxicity towards normal cells. | Adjuvants, Immunologic (Code: D000276) Immunologic Factors (Code: D007155) | 2009-03-06 EMA | |
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| buserelin | Lutropin-choriogonadotropic hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P22888, gene: LHCGR, swissprot: LSHR_HUMAN) Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications. | Fertility Agents (Code: D005299) Fertility Agents, Female (Code: D005300) Reproductive Control Agents (Code: D012102) | 1984-01-01 YEAR INTRODUCED | |
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| abarelix | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | None | Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) hormone antagonist (Code: CHEBI:49020) antineoplastic agent (Code: CHEBI:35610) | 2003-11-25 FDA | |
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| iocarmic acid | see also iocarmate meglumine | |
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| dactinomycin | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Growth factor receptor-bound protein 2 (Organism: Homo sapiens, class: Cytosolic other, accessions: P62993, gene: GRB2, swissprot: GRB2_HUMAN) Growth factor receptor-bound protein 2 (Organism: Mus musculus, class: Cytosolic other, accessions: Q60631, gene: Grb2, swissprot: GRB2_MOUSE) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) | A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) | Actinomycin (Code: N0000180850) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Protein Synthesis Inhibitors (Code: D011500) | 1964-12-10 FDA | |
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| ioxaglic acid | A low-osmolar, ionic contrast medium used in various radiographic procedures. | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1985-07-26 FDA | |
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| goserelin | Lutropin-choriogonadotropic hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P22888, gene: LHCGR, swissprot: LSHR_HUMAN) Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer. | Gonadotropin Releasing Hormone Receptor Agonist (Code: N0000175655) Gonadotropin Releasing Hormone Receptor Agonists (Code: N0000175654) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) | 1989-12-29 FDA | |
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| micafungin | Beta-1,3-glucan synthase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Unclassified, accessions: Q5AIC4, gene: GSC1, swissprot: Q5AIC4_CANAL) Beta-1,3-glucan synthase catalytic subunit 1 (Organism: Candida albicans, class: Enzyme, accessions: O13428, gene: GSC1, swissprot: O13428_CANAX) | a cyclic hexapeptide echinocandin lipopeptide | Echinocandin Antifungal (Code: N0000175507) Lipopeptides (Code: N0000175508) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) antiinfective agent (Code: CHEBI:35441) | 2005-03-16 FDA | |
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| cetrorelix | Lutropin-choriogonadotropic hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P22888, gene: LHCGR, swissprot: LSHR_HUMAN) Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | LHRH antagonist | Decreased GnRH Secretion (Code: N0000008638) Gonadotropin Releasing Hormone Antagonist (Code: N0000175839) Gonadotropin Releasing Hormone Receptor Antagonists (Code: N0000175084) Fertility Agents (Code: D005299) Fertility Agents, Female (Code: D005300) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Reproductive Control Agents (Code: D012102) GnRH antagonist (Code: CHEBI:59229) antineoplastic agent (Code: CHEBI:35610) | 2000-08-11 FDA | |
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| iodoxamic acid | radiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt; minor descriptor (81-86); on-line & INDEX MEDICUS search TRIIODOBENZOIC ACIDS (81-86) | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | 1981-08-14 FDA | |
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| suramin | P2Y purinoceptor 11 (Organism: Homo sapiens, class: GPCR, accessions: Q96G91, gene: P2RY11, swissprot: P2Y11_HUMAN) P2Y purinoceptor 13 (Organism: Homo sapiens, class: GPCR, accessions: Q9BPV8, gene: P2RY13, swissprot: P2Y13_HUMAN) P2Y purinoceptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P47900, gene: P2RY1, swissprot: P2RY1_HUMAN) P2Y purinoceptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P41231, gene: P2RY2, swissprot: P2RY2_HUMAN) P2X purinoceptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q99571, gene: P2RX4, swissprot: P2RX4_HUMAN) P2X purinoceptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P56373, gene: P2RX3, swissprot: P2RX3_HUMAN) Nucleoside triphosphate diphosphohydrolase 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q80Z26, gene: Entpd3, swissprot: Q80Z26_RAT) ATP-dependent 6-phosphofructokinase (Organism: Trypanosoma brucei brucei, class: Kinase, accessions: O15648, gene: pfk, swissprot: PFKA_TRYBB) Protein kinase C (PKC) (Organism: Homo sapiens, class: Kinase, accessions: O94806|P05129|P05771|P17252|P24723|P41743|Q02156|Q04759|Q05513|Q05655|Q15139, gene: PRKCA|PRKCB|PRKCD|PRKCE|PRKCG|PRKCH|PRKCI|PRKCQ|PRKCZ|PRKD1|PRKD3, swissprot: KPCA_HUMAN|KPCB_HUMAN|KPCD1_HUMAN|KPCD3_HUMAN|KPCD_HUMAN|KPCE_HUMAN|KPCG_HUMAN|KPCI_HUMAN|KPCL_HUMAN|KPCT_HUMAN|KPCZ_HUMAN) RmtA (Organism: Emericella nidulans, class: Enzyme, accessions: Q5VLE3, gene: rmtA, swissprot: Q5VLE3_EMEND) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) DNA-dependent protein kinase catalytic subunit (Organism: Homo sapiens, class: Kinase, accessions: P78527, gene: PRKDC, swissprot: PRKDC_HUMAN) Ectonucleoside triphosphate diphosphohydrolase 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: O35795, gene: Entpd2, swissprot: ENTP2_RAT) NAD-dependent protein deacylase sirtuin-5, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9NXA8, gene: SIRT5, swissprot: SIR5_HUMAN) Protein arginine N-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q99873, gene: PRMT1, swissprot: ANM1_HUMAN) NAD-dependent protein deacetylase sirtuin-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q8IXJ6, gene: SIRT2, swissprot: SIR2_HUMAN) NAD-dependent protein deacetylase sirtuin-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q96EB6, gene: SIRT1, swissprot: SIR1_HUMAN) P2X purinoceptor 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: P47824, gene: P2rx1, swissprot: P2RX1_RAT) P2X purinoceptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P49653, gene: P2rx2, swissprot: P2RX2_RAT) P2X purinoceptor 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: P49654, gene: P2rx3, swissprot: P2RX3_RAT) P2X purinoceptor 5 (Organism: Rattus norvegicus, class: Unclassified, accessions: P51578, gene: P2rx5, swissprot: P2RX5_RAT) P2Y purinoceptor 6 (Organism: Homo sapiens, class: GPCR, accessions: Q15077, gene: P2RY6, swissprot: P2RY6_HUMAN) | A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Trypanocidal Agents (Code: D014344) antinematodal drug (Code: CHEBI:35444) trypanocidal drug (Code: CHEBI:36335) | 1Y4L 1Y8E 2H9T 2NYR 3BF6 3BJW 3GAN 3PP7 3UR0 4J4V 4X3U 4YV5 |
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| triptorelin | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE with D-tryptophan substitution at residue 6. | Gonadotropin Releasing Hormone Receptor Agonist (Code: N0000175655) Gonadotropin Releasing Hormone Receptor Agonists (Code: N0000175654) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Hormonal (Code: D018931) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Luteolytic Agents (Code: D008186) Reproductive Control Agents (Code: D012102) gonadotropin releasing hormone agonist (Code: CHEBI:63533) antineoplastic agent (Code: CHEBI:35610) contraceptive drug (Code: CHEBI:49323) | 2000-06-15 FDA | |
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| eritoran | Toll-like receptor 4 (Organism: Homo sapiens, class: Membrane receptor, accessions: O00206, gene: TLR4, swissprot: TLR4_HUMAN) | None | |
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| nafarelin | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | A potent synthetic agonist of GONADOTROPIN-RELEASING HORMONE with 3-(2-naphthyl)-D-alanine substitution at residue 6. Nafarelin has been used in the treatments of central PRECOCIOUS PUBERTY and ENDOMETRIOSIS. | Gonadotropin Releasing Hormone Receptor Agonist (Code: N0000175655) Gonadotropin Releasing Hormone Receptor Agonists (Code: N0000175654) Fertility Agents (Code: D005299) Fertility Agents, Female (Code: D005300) Reproductive Control Agents (Code: D012102) | 1990-02-13 FDA | |
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| histrelin | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | gonadotropin releasing hormone agonist | Gonadotropin Releasing Hormone Receptor Agonist (Code: N0000175655) Gonadotropin Releasing Hormone Receptor Agonists (Code: N0000175654) antineoplastic agent (Code: CHEBI:35610) gonadotropin releasing hormone agonist (Code: CHEBI:63533) | 1991-12-24 FDA | |
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| depreotide | None | |
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| vancomycin | D-alanyl-D-alanine dipeptidase (Organism: Enterococcus faecium, class: Unclassified, accessions: Q06241, gene: vanX, swissprot: VANX_ENTFC) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P17443, gene: murG, swissprot: MURG_ECOLI) | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. | Glycopeptide Antibacterial (Code: N0000175491) Glycopeptides (Code: N0000007889) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1964-11-06 FDA | |
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| peplomycin | An antineoplastic agent derived from BLEOMYCIN. | Antibiotics, Antineoplastic (Code: D000903) Antineoplastic Agents (Code: D000970) | |
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| fondaparinux | Antithrombin-III (Organism: Homo sapiens, class: Secreted, accessions: P01008, gene: SERPINC1, swissprot: ANT3_HUMAN) | MW 1714 daltons; synthetic pentasaccharide representing minimum binding sequence of heparin to antithrombin III | Factor Xa Inhibitor (Code: N0000175637) Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Factor Xa Inhibitors (Code: D065427) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) | 2001-12-07 FDA | 2GD4 3EVJ 4R9W 4X7R 5WD7 |
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| betadex | None | Food Additives (Code: D005503) Sequestering Agents (Code: D064449) | 1DMB 1G1Y 1GVI 1JL8 1Z0M 1Z0N 2Y4S 2ZYN 3C6G 3CGT 3CK8 3CZH 3DL9 3EDJ 3JUS 3JUV 3LD6 3M3R 3M4E 3QGV 3ZBY 3ZT7 4D5D 4RER 5AB1 5E6Z 5MK9 |
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| iodixanol | dimeric contrast media; structure given in first source | Radiographic Contrast Agent (Code: N0000180185) X-Ray Contrast Activity (Code: N0000010258) Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | 1996-03-22 FDA | |
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| ganirelix | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | None | Decreased GnRH Secretion (Code: N0000008638) Gonadotropin Releasing Hormone Antagonist (Code: N0000175839) Gonadotropin Releasing Hormone Receptor Antagonists (Code: N0000175084) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1999-07-29 FDA | |
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| daptomycin | Outer membrane porin protein OmpD (Organism: Salmonella choleraesuis (strain SC-B67), class: Unclassified, accessions: Q57P83, gene: ompD, swissprot: OMPD_SALCH) | A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA. | Lipopeptide Antibacterial (Code: N0000175509) Lipopeptides (Code: N0000175508) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 2003-09-12 FDA | |
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| iotrolan | nonionic, isotonic contrast medium designed for intrathecal use; RN given refers to cpd without isomeric designation; DL-3-117 refers to stereoisomer; structure given in first source | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) | None FDA | |
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| lercanidipine | Voltage-gated L-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: Q01668|Q13936, gene: CACNA1C|CACNA1D, swissprot: CAC1C_HUMAN|CAC1D_HUMAN) | None | Antihypertensive Agents (Code: D000959) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) | |
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| somatostatin | Somatostatin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P30874, gene: SSTR2, swissprot: SSR2_HUMAN) Somatostatin receptor type 5 (Organism: Rattus norvegicus, class: GPCR, accessions: P30938, gene: Sstr5, swissprot: SSR5_RAT) Somatostatin receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P30872, gene: SSTR1, swissprot: SSR1_HUMAN) Somatostatin receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P35346, gene: SSTR5, swissprot: SSR5_HUMAN) Somatostatin receptor type 3 (Organism: Mus musculus, class: GPCR, accessions: P30935, gene: Sstr3, swissprot: SSR3_MOUSE) Somatostatin receptor type 3 (Organism: Homo sapiens, class: GPCR, accessions: P32745, gene: SSTR3, swissprot: SSR3_HUMAN) Somatostatin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P28646|P30680|P30936|P30937|P30938, gene: Sstr1|Sstr2|Sstr3|Sstr4|Sstr5, swissprot: SSR1_RAT|SSR2_RAT|SSR3_RAT|SSR4_RAT|SSR5_RAT) Somatostatin receptor (Organism: Mus musculus, class: GPCR, accessions: O08858|P30873|P30875|P30935|P49660, gene: Sstr1|Sstr2|Sstr3|Sstr4|Sstr5, swissprot: SSR1_MOUSE|SSR2_MOUSE|SSR3_MOUSE|SSR4_MOUSE|SSR5_MOUSE) Somatostatin receptor type 2 (Organism: Mus musculus, class: GPCR, accessions: P30875, gene: Sstr2, swissprot: SSR2_MOUSE) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Somatostatin receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P31391, gene: SSTR4, swissprot: SSR4_HUMAN) | A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. | Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | |
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| telavancin | an anti-infective agent | Lipoglycopeptide Antibacterial (Code: N0000191281) Lipoglycopeptides (Code: N0000191280) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 2009-09-11 FDA | |
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| artenimol | Artenimol is able to reach high concentrations within the parasitized erythrocytes. Its endoperoxide bridge is thought to be essential for its antimalarial activity, causing free-radical damage to parasite membrane systems. | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | 2011-10-27 EMA | |
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| dalbavancin | Dalbavancin, a semisynthetic lipoglycopeptide, interferes with cell wall synthesis by binding to the D-alanyl-D-alanine terminus of the stem pentapeptide in nascent cell wall peptidoglycan, thus preventing cross-linking. Dalbavancin is bactericidal in vitro against Staphylococcus aureus and Streptococcus pyogenes at concentrations similar to those sustained throughout treatment in humans treated according to the recommended dosage regimen. | Lipoglycopeptide Antibacterial (Code: N0000191281) Lipoglycopeptides (Code: N0000191280) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 2014-12-18 EMA 2014-05-23 FDA | |
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| alsactide | None | |
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| bivalirudin | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) | designed to bind to the alpha-thrombin catalytic site and anion-binding exosite for fibrin(ogen) recognition | Anti-coagulant (Code: N0000175980) Direct Thrombin Inhibitor (Code: N0000175518) Thrombin Inhibitors (Code: N0000009963) Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) | 2000-12-15 FDA | |
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| ziconotide | Voltage-dependent N-type calcium channel subunit alpha-1B (Organism: Homo sapiens, class: Ion channel, accessions: Q00975, gene: CACNA1B, swissprot: CAC1B_HUMAN) Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Organism: Rattus norvegicus, class: Unclassified, accessions: P54282, gene: Cacna1a, swissprot: CAC1A_RAT) | Ziconotide binds to N-type calcium channels located on the primary nociceptive (A-delta and C) afferent nerves in the superficial layers (Rexed laminae I and II) of the dorsal horn in the spinal cord. Although the mechanism of action of ziconotide has not been established in humans, results in animals suggest that its binding blocks N-type calcium channels, which leads to a blockade of excitatory neurotransmitter release from the primary afferent nerve terminals and antinociception. | N-Calcium Channel Receptor Antagonists (Code: N0000020069) N-type Calcium Channel Antagonist (Code: N0000175697) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neuroprotective Agents (Code: D018696) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sensory System Agents (Code: D018689) | 2004-12-28 FDA | |
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| alpha-tocopherol acetate | None | 2000-05-18 FDA | |
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| secretin human | Secretin receptor (Organism: Homo sapiens, class: GPCR, accessions: P47872, gene: SCTR, swissprot: SCTR_HUMAN) | A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597) | Secretin (Code: N0000006078) Secretin-class Hormone (Code: N0000175813) Gastrointestinal Agents (Code: D005765) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 2002-04-04 FDA | |
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| carperitide | None | |
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| telotristat ethyl | Tryptophan 5-hydroxylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P17752, gene: TPH1, swissprot: TPH1_HUMAN) | Telotristat, the active metabolite of telotristat ethyl, is an inhibitor of tryptophan hydroxylase, which mediates the rate limiting step in serotonin biosynthesis. The in vitro inhibitory potency of telotristat towards tryptophan hydroxylase is 29 times higher than that of telotristat ethyl. Serotonin plays a role in mediating secretion, motility, inflammation, and sensation of the gastrointestinal tract, and is over-produced in patients with carcinoid syndrome. Through inhibition of tryptophan hydroxylase, telotristat and telotristat ethyl reduce the production of peripheral serotonin, and the frequency of carcinoid syndrome diarrhea. | 2017-02-28 FDA | |
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| beclabuvir | Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | None | 2016-12-19 PMDA | 4NLD |
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| thymalfasin | isolated from thymus gland; octaeicosapeptide; one of the polypeptides of thymosin fraction V; see also record for thymosin fraction V; FDA approved orphan drug status for malignant melanoma although mechanism uncertain | Adjuvants, Immunologic (Code: D000276) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) | |
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| sermorelin | Growth hormone-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q02643, gene: GHRHR, swissprot: GHRHR_HUMAN) | The biologically active fragment of human growth hormone-releasing factor, consisting of GHRH(1-29)-amide. This N-terminal sequence is identical in several mammalian species, such as human, pig, and cattle. It is used to diagnose or treat patients with GROWTH HORMONE deficiency. | 1990-12-28 FDA | |
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| ribociclib | Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) Cyclin-dependent kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q00534, gene: CDK6, swissprot: CDK6_HUMAN) | Ribociclib is an inhibitor of cyclin-dependent kinase (CDK) 4 and 6. These kinases are activated upon binding to D-cyclins and play a crucial role in signaling pathways which lead to cell cycle progression and cellular proliferation. The cyclin D-CDK4/6 complex regulates cell cycle progression through phosphorylation of the retinoblastoma protein (pRb). In vitro, ribociclib decreased pRb phosphorylation leading to arrest in the G1 phase of the cell cycle and reduced cell proliferation in breast cancer cell lines. In vivo, treatment with single agent ribociclib in a rat xenograft model with human tumor cells led to decreased tumor volumes, which correlated with inhibition of pRb phosphorylation. In studies using patient-derived estrogen receptor positive breast cancer xenograft models, combination of ribociclib and antiestrogen (e.g. letrozole) resulted in increased tumor growth inhibition compared to each drug alone. | Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) Cytochrome P450 3A Inhibitors (Code: N0000190114) | 2017-03-13 FDA | 5L2T |
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| naldemedine | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) | Naldemedine is an opioid antagonist with binding affinities for mu-, delta-, and kappa-opioid receptors. Naldemedine functions as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids. | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) | 2017-03-23 FDA | |
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| hydrocortisone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) | None | Anti-Inflammatory Agents (Code: D000893) | 1951-12-21 FDA | |
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| calcitonin (salmon synthetic) | Calcitonin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30988, gene: CALCR, swissprot: CALCR_HUMAN) Amylin receptor AMY1 (Organism: Homo sapiens, class: GPCR, accessions: O60894|P30988, gene: CALCR|RAMP1, swissprot: CALCR_HUMAN|RAMP1_HUMAN) Amylin receptor AMY2 (Organism: Homo sapiens, class: GPCR, accessions: O60895|P30988, gene: CALCR|RAMP2, swissprot: CALCR_HUMAN|RAMP2_HUMAN) Amylin receptor AMY3 (Organism: Homo sapiens, class: GPCR, accessions: O60896|P30988, gene: CALCR|RAMP3, swissprot: CALCR_HUMAN|RAMP3_HUMAN) | None | Calcitonin (Code: N0000006509) Bone Density Conservation Agents (Code: D050071) bone density conservation agent (Code: CHEBI:50646) | 1978-04-17 FDA | |
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| calcitonin (pork natural) | None | |
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| chidamide | Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) Histone deacetylase 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q96DB2, gene: HDAC11, swissprot: HDA11_HUMAN) | An orally bioavailable benzamide-type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide binds to and inhibits HDACs, leading to an increase of acetylation levels of histone proteins. This agent also inhibits the expression of kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide-type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. | 2014-12-23 China Food and Drug Administration (CFDA) | |
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| nesiritide | Atrial natriuretic peptide receptor 1 (Organism: Homo sapiens, class: Enzyme, accessions: P16066, gene: NPR1, swissprot: ANPRA_HUMAN) | None | Natriuretic Peptide (Code: N0000175593) Natriuretic Peptides (Code: N0000011465) | 2001-08-10 FDA | |
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| isopropanol | An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic. | Solvents (Code: D012997) protic solvent (Code: CHEBI:48356) | None FDA | |
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| deutetrabenazine | Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) | The precise mechanism by which deutetrabenazine exerts its anti-chorea effects is unknown but is believed to be related to its effect as a reversible depletor of monoamines (such as dopamine, serotonin, norepinephrine, and histamine) from nerve terminals. The major circulating metabolites (alpha-dihydrotetrabenazine [HTBZ] and beta-HTBZ) of deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake of monoamines into synaptic vesicles and depletion of monoamine stores. | 2017-04-03 FDA | |
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| glucagon | Glucagon-like peptide 1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P43220, gene: GLP1R, swissprot: GLP1R_HUMAN) Glucagon receptor (Organism: Homo sapiens, class: GPCR, accessions: P47871, gene: GCGR, swissprot: GLR_HUMAN) Glucagon receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30082, gene: Gcgr, swissprot: GLR_RAT) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) | A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511) | Antihypoglycemic Agent (Code: N0000190852) Gastrointestinal Motility Inhibitor (Code: N0000190853) Increased Gluconeogenesis (Code: N0000009340) Increased Glycogenolysis (Code: N0000009345) Decreased GI Smooth Muscle Tone (Code: N0000008636) Decreased GI Motility (Code: N0000008635) Decreased Glycolysis (Code: N0000008652) Gastrointestinal Agents (Code: D005765) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1960-11-14 FDA | |
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| ruxolitinib | Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Phosphatidylinositol 4-kinase beta (Organism: Homo sapiens, class: Kinase, accessions: Q9UBF8, gene: PI4KB, swissprot: PI4KB_HUMAN) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92630, gene: DYRK2, swissprot: DYRK2_HUMAN) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) Serine/threonine-protein kinase Nek3 (Organism: Homo sapiens, class: Kinase, accessions: P51956, gene: NEK3, swissprot: NEK3_HUMAN) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit beta (Organism: Homo sapiens, class: Kinase, accessions: Q13554, gene: CAMK2B, swissprot: KCC2B_HUMAN) Death-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UIK4, gene: DAPK2, swissprot: DAPK2_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) Mitogen-activated protein kinase kinase kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q6ZN16, gene: MAP3K15, swissprot: M3K15_HUMAN) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) JAK2/TYK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674|P29597, gene: JAK2|TYK2, swissprot: JAK2_HUMAN|TYK2_HUMAN) JAK1/JAK2/TYK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674|P23458|P29597, gene: JAK1|JAK2|TYK2, swissprot: JAK1_HUMAN|JAK2_HUMAN|TYK2_HUMAN) JAK1/TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P23458|P29597, gene: JAK1|TYK2, swissprot: JAK1_HUMAN|TYK2_HUMAN) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) Serine/threonine-protein kinase PLK1 (Organism: Homo sapiens, class: Kinase, accessions: P53350, gene: PLK1, swissprot: PLK1_HUMAN) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) Serine/threonine-protein kinase Nek7 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDX7, gene: NEK7, swissprot: NEK7_HUMAN) Serine/threonine-protein kinase/endoribonuclease IRE1 (Organism: Homo sapiens, class: Kinase, accessions: O75460, gene: ERN1, swissprot: ERN1_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Serine/threonine-protein kinase OSR1 (Organism: Homo sapiens, class: Kinase, accessions: O95747, gene: OXSR1, swissprot: OXSR1_HUMAN) STE20/SPS1-related proline-alanine-rich protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UEW8, gene: STK39, swissprot: STK39_HUMAN) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) JAK3/JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458|P52333, gene: JAK1|JAK3, swissprot: JAK1_HUMAN|JAK3_HUMAN) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) JAK2/JAK1 (Organism: Homo sapiens, class: Kinase, accessions: O60674|P23458, gene: JAK1|JAK2, swissprot: JAK1_HUMAN|JAK2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: Q13555, gene: CAMK2G, swissprot: KCC2G_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) Serine/threonine-protein kinase MARK2 (Organism: Homo sapiens, class: Kinase, accessions: Q7KZI7, gene: MARK2, swissprot: MARK2_HUMAN) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) Serine/threonine-protein kinase 25 (Organism: Homo sapiens, class: Kinase, accessions: O00506, gene: STK25, swissprot: STK25_HUMAN) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) Serine/threonine-protein kinase DCLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8N568, gene: DCLK2, swissprot: DCLK2_HUMAN) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) Serine/threonine-protein kinase PAK 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9NQU5, gene: PAK6, swissprot: PAK6_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) Serine/threonine-protein kinase PAK 7 (Organism: Homo sapiens, class: Kinase, accessions: Q9P286, gene: PAK5, swissprot: PAK5_HUMAN) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) Calcium/calmodulin-dependent protein kinase type 1G (Organism: Homo sapiens, class: Kinase, accessions: Q96NX5, gene: CAMK1G, swissprot: KCC1G_HUMAN) Inhibitor of nuclear factor kappa-B kinase subunit beta (Organism: Homo sapiens, class: Kinase, accessions: O14920, gene: IKBKB, swissprot: IKKB_HUMAN) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) Rhodopsin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q15835, gene: GRK1, swissprot: RK_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) Serine/threonine-protein kinase PLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NYY3, gene: PLK2, swissprot: PLK2_HUMAN) Bone morphogenetic protein receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: Q13873, gene: BMPR2, swissprot: BMPR2_HUMAN) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) Peripheral plasma membrane protein CASK (Organism: Homo sapiens, class: Kinase, accessions: O14936, gene: CASK, swissprot: CSKP_HUMAN) Serine/threonine-protein kinase PknB (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WI81, gene: pknB, swissprot: PKNB_MYCTU) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Casein kinase I isoform alpha (Organism: Homo sapiens, class: Kinase, accessions: P48729, gene: CSNK1A1, swissprot: KC1A_HUMAN) Mitogen-activated protein kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13233, gene: MAP3K1, swissprot: M3K1_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Serine/threonine-protein kinase SIK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2K2, gene: SIK3, swissprot: SIK3_HUMAN) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Death-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53355, gene: DAPK1, swissprot: DAPK1_HUMAN) Uncharacterized serine/threonine-protein kinase SBK3 (Organism: Homo sapiens, class: Kinase, accessions: P0C264, gene: SBK3, swissprot: SBK3_HUMAN) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) Serine/threonine-protein kinase PAK 4 (Organism: Homo sapiens, class: Kinase, accessions: O96013, gene: PAK4, swissprot: PAK4_HUMAN) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Serine/threonine-protein kinase PLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H4B4, gene: PLK3, swissprot: PLK3_HUMAN) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) Serine/threonine-protein kinase VRK2 (Organism: Homo sapiens, class: Kinase, accessions: Q86Y07, gene: VRK2, swissprot: VRK2_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) Serine/threonine-protein kinase RIO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BVS4, gene: RIOK2, swissprot: RIOK2_HUMAN) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit delta (Organism: Homo sapiens, class: Kinase, accessions: Q13557, gene: CAMK2D, swissprot: KCC2D_HUMAN) cGMP-dependent protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13237, gene: PRKG2, swissprot: KGP2_HUMAN) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) | a kinase inhibitor, inhibits Janus Associated Kinases (JAKs) JAK1 and JAK2 which mediate the signaling of a number of cytokines and growth factors that are important for hematopoiesis and immune function | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) antineoplastic agent (Code: CHEBI:35610) | 2011-11-16 FDA | 4U5J |
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| fesoterodine | Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) | a muscarinic antagonist for treatment of overactive bladder | Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) | 2008-10-31 FDA | |
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| tafamidis | Transthyretin (Organism: Homo sapiens, class: Secreted, accessions: P02766, gene: TTR, swissprot: TTHY_HUMAN) | may be effective in treating transthyretin amyloid polyneuropathy | central nervous system drug (Code: CHEBI:35470) | 2011-11-16 EMA | 3TCT 4HIS |
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| piperaquine | The exact mechanism of action of piperaquine is unknown, but it likely mirrors that of chloroquine, a close structural analogue. Chloroquine binds to toxic haeme (derived from the patient's haemoglobin) within the malaria parasite, preventing its detoxification via a polymerisation step. | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) antimalarial (Code: CHEBI:38068) | 2011-10-27 EMA | |
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| domiphen | None | |
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| pramlintide | Amylin receptor AMY1 (Organism: Homo sapiens, class: GPCR, accessions: O60894|P30988, gene: CALCR|RAMP1, swissprot: CALCR_HUMAN|RAMP1_HUMAN) Amylin receptor AMY3 (Organism: Homo sapiens, class: GPCR, accessions: O60896|P30988, gene: CALCR|RAMP3, swissprot: CALCR_HUMAN|RAMP3_HUMAN) Amylin receptor AMY2 (Organism: Homo sapiens, class: GPCR, accessions: O60895|P30988, gene: CALCR|RAMP2, swissprot: CALCR_HUMAN|RAMP2_HUMAN) | Pramlintide is an analog of human amylin. Amylin is colocated with insulin in secretory granules and cosecreted with insulin by pancreatic beta cells in response to food intake. Amylin and insulin show similar fasting and postprandial patterns in healthy individuals. In patients with type 1 and type 2 diabetes, there is reduced secretion from pancreatic beta cells of both insulin and amylin in response to food. Amylin affects the rate of postprandial glucose appearance through a variety of mechanisms, as determined by nonclinical studies. Amylin slows gastric emptying (i.e., the rate at which food is released from the stomach to the small intestine) without altering the overall absorption of nutrients. In addition, amylin suppresses glucagon secretion (not normalized by insulin alone), which leads to suppression of endogenous glucose output from the liver. Amylin also regulates food intake due to centrally-mediated modulation of appetite. In human studies, pramlintide, acting as an amylin analog, slows gastric emptying, reduces the postprandial rise in plasma glucagon, and modulates satiety leading to decreased caloric intake. | Amylin Agonists (Code: N0000020064) Amylin Analog (Code: N0000177910) Hypoglycemic Agents (Code: D007004) | 2005-03-16 FDA | |
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| exenatide | Glucagon-like peptide 1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P32301, gene: Glp1r, swissprot: GLP1R_RAT) Glucagon-like peptide 1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P43220, gene: GLP1R, swissprot: GLP1R_HUMAN) | amino acid sequence given in first source; isolated from the venom of the lizard Heloderma suspectum; increases pancreatic acinar cAMP; identical to exendin-3 except that Gly(2)-Glu(3) replaces Ser(2)-Asp(3); exenatide is a synthetic version of exendin-4; has antidiabetic and antiobesity activities; binds to GLP-1 receptor as GLP-1 agonist | GLP-1 Receptor Agonist (Code: N0000178480) Glucagon-Like Peptide 1 (Code: N0000170335) Glucagon-like Peptide-1 (GLP-1) Agonists (Code: N0000020058) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Incretins (Code: D054795) Hypoglycemic Agents (Code: D007004) hypoglycemic agent (Code: CHEBI:35526) | 2005-04-28 FDA | |
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| enfuvirtide | Envelope glycoprotein (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q53I07, gene: gp41, swissprot: Q53I07_9HIV1) Transmembrane glycoprotein gp41 (Organism: Human immunodeficiency virus, class: Membrane other, accessions: O40239, gene: env, swissprot: O40239_9PLVG) GP41 (Organism: Human immunodeficiency virus 1, class: Unclassified, accessions: Q76270, gene: HIV1 ENV, swissprot: Q76270_9HIV1) | Enfuvirtide interferes with the entry of HIV-1 into cells by inhibiting fusion of viral and cellular membranes. Enfuvirtide binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion of viral and cellular membranes. | Fusion Protein Inhibitors (Code: N0000175615) Human Immunodeficiency Virus 1 Fusion Inhibitor (Code: N0000175616) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) HIV Fusion Inhibitors (Code: D023581) HIV fusion inhibitor (Code: CHEBI:59886) | 2003-03-13 FDA | |
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| vitamin A palmitate | Retinol-binding protein 4 (Organism: Homo sapiens, class: Secreted, accessions: P02753, gene: RBP4, swissprot: RET4_HUMAN) Beta-lactoglobulin (Organism: Bos taurus, class: Unclassified, accessions: P02754, gene: LGB, swissprot: LACB_BOVIN) | None | Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Antioxidants (Code: D000975) Protective Agents (Code: D020011) | 1949-05-18 FDA | |
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| prazosin | 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) Interstitial collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P03956, gene: MMP1, swissprot: MMP1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Alpha-2A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P22909, gene: Adra2a, swissprot: ADA2A_RAT) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) Alpha-2A adrenergic receptor (Organism: Sus scrofa, class: GPCR, accessions: P18871, gene: ADRA2A, swissprot: ADA2A_PIG) Alpha-2 adrenergic receptor (Organism: Mus musculus, class: GPCR, accessions: P30545|Q01337|Q01338, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_MOUSE|ADA2B_MOUSE|ADA2C_MOUSE) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Multidrug and toxin extrusion protein 2 (Organism: Homo sapiens, class: Transporter, accessions: Q86VL8, gene: SLC47A2, swissprot: S47A2_HUMAN) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) Alpha-2A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28838, gene: ADRA2A, swissprot: ADA2A_BOVIN) Ribosyldihydronicotinamide dehydrogenase [quinone] (Organism: Homo sapiens, class: Enzyme, accessions: P16083, gene: NQO2, swissprot: NQO2_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) Beta-casein (Organism: Rattus norvegicus, class: Unclassified, accessions: P02665, gene: Csn2, swissprot: CASB_RAT) | A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION. | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) antihypertensive agent (Code: CHEBI:35674) alpha-adrenergic antagonist (Code: CHEBI:37890) | 1976-06-23 FDA | 3OWX |
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| acetic acid | Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) | Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) | Indicators and Reagents (Code: D007202) food acidity regulator (Code: CHEBI:64049) protic solvent (Code: CHEBI:48356) antimicrobial food preservative (Code: CHEBI:65256) | 1960-05-17 FDA | |
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| migalastat | Alpha-galactosidase A (Organism: Homo sapiens, class: Enzyme, accessions: P06280, gene: GLA, swissprot: AGAL_HUMAN) Beta-galactosidase (Organism: Homo sapiens, class: Enzyme, accessions: P16278, gene: GLB1, swissprot: BGAL_HUMAN) Lactase-phlorizin hydrolase (Organism: Homo sapiens, class: Enzyme, accessions: P09848, gene: LCT, swissprot: LPH_HUMAN) Glycogen debranching enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P35573, gene: AGL, swissprot: GDE_HUMAN) Sucrase-isomaltase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: P14410, gene: SI, swissprot: SUIS_HUMAN) Non-lysosomal glucosylceramidase (Organism: Homo sapiens, class: Enzyme, accessions: Q9HCG7, gene: GBA2, swissprot: GBA2_HUMAN) Lysosomal alpha-glucosidase (Organism: Homo sapiens, class: Enzyme, accessions: P10253, gene: GAA, swissprot: LYAG_HUMAN) Maltase-glucoamylase, intestinal (Organism: Homo sapiens, class: Enzyme, accessions: O43451, gene: MGAM, swissprot: MGA_HUMAN) Beta-galactosidase (Organism: Rattus norvegicus, class: Unclassified, accessions: D3ZUM4, gene: Glb1, swissprot: D3ZUM4_RAT) Lactase-phlorizin hydrolase (Organism: Rattus norvegicus, class: Unclassified, accessions: Q02401, gene: Lct, swissprot: LPH_RAT) Alpha-galactosidase (Organism: Coffea arabica, class: Unclassified, accessions: Q42656, gene: None, swissprot: AGAL_COFAR) Beta-galactosidase (Organism: Rhizobium meliloti, class: Unclassified, accessions: Q59750, gene: lacZ, swissprot: BGAL_RHIML) Alpha-galactosidase C (Organism: Aspergillus niger, class: Unclassified, accessions: Q9UUZ4, gene: aglC, swissprot: AGALC_ASPNG) | Migalastat is a pharmacological chaperone that is designed to selectively and reversibly bind with high affinity to the active sites of certain mutant forms of alpha-Gal A, the genotypes of which are referred to as amenable mutations. Migalastat binding stabilizes these mutant forms of alpha-Gal A in the endoplasmic reticulum and facilitates their proper trafficking to lysosomes where dissociation of migalastat restores alpha-Gal A activity, leading to the catabolism of GL-3 and related substrates. | 2016-05-26 EMA | 3S5Y 3THD 3TV8 4CU8 4D1J 4DO5 4FNS 4UFM |
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| amfecloral | None | |
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| dexfosfoserine | Metabotropic glutamate receptor 8 (Organism: Homo sapiens, class: GPCR, accessions: O00222, gene: GRM8, swissprot: GRM8_HUMAN) Metabotropic glutamate receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: O15303, gene: GRM6, swissprot: GRM6_HUMAN) Metabotropic glutamate receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: Q14831, gene: GRM7, swissprot: GRM7_HUMAN) Metabotropic glutamate receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: P31423, gene: Grm4, swissprot: GRM4_RAT) Metabotropic glutamate receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q14833, gene: GRM4, swissprot: GRM4_HUMAN) Metabotropic glutamate receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P35349, gene: Grm6, swissprot: GRM6_RAT) | The phosphoric acid ester of serine. | |
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| lubiprostone | Chloride channel protein 2 (Organism: Homo sapiens, class: Ion channel, accessions: P51788, gene: CLCN2, swissprot: CLCN2_HUMAN) | Member of a bicyclic fatty acid class of compounds derived from PROSTAGLANDIN E1 involved in chloride channel gating. | Chloride Channel Activator (Code: N0000175573) Chloride Channel Activators (Code: N0000175456) Chloride Channel Agonists (Code: D065101) Membrane Transport Modulators (Code: D049990) | 2006-01-31 FDA | |
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| proline | Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) Angiotensin-converting enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P12821, gene: ACE, swissprot: ACE_HUMAN) | A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. | None FDA | |
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| asparagine | A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) | nutraceutical (Code: CHEBI:50733) | |
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| serine | Gamma-glutamyltranspeptidase 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: P07314, gene: Ggt1, swissprot: GGT1_RAT) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) | A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. | None FDA | |
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| valine | A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway. | nutraceutical (Code: CHEBI:50733) | None FDA | |
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| isoleucine | An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels. | None FDA | |
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| silodosin | Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) | an alpha(1a)-adrenoceptor-selective antagonist; structure given in first source | alpha-Adrenergic Blocker (Code: N0000175553) Adrenergic Agents (Code: D018663) Adrenergic alpha-1 Receptor Antagonists (Code: D058668) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) | 2008-10-08 FDA 2010-01-29 EMA | |
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| pyridoxal | Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) | The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | 1TD2 2DDW 2Z9W 2Z9X 3FHX 3MBH 4C5L 4C5N |
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| lisdexamfetamine | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) | A dextroamphetamine drug precursor that also functions as a CENTRAL NERVOUS SYSTEM STIMULANT and DOPAMINE UPTAKE INHIBITOR and is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. | Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) | 2007-02-23 FDA | |
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| paliperidone | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) 5-hydroxytryptamine receptor 1E (Organism: Homo sapiens, class: GPCR, accessions: P28566, gene: HTR1E, swissprot: 5HT1E_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | None | Atypical Antipsychotic (Code: N0000175430) dopaminergic antagonist (Code: CHEBI:48561) serotonergic antagonist (Code: CHEBI:48279) alpha-adrenergic antagonist (Code: CHEBI:37890) H1-receptor antagonist (Code: CHEBI:37955) psychotropic drug (Code: CHEBI:35471) second generation antipsychotic (Code: CHEBI:65191) neuroprotective agent (Code: CHEBI:63726) | 2007-06-25 EMA 2006-12-19 FDA | |
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| gentian violet | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Substance-K receptor (Organism: Homo sapiens, class: GPCR, accessions: P21452, gene: TACR2, swissprot: NK2R_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) | A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) histological dye (Code: CHEBI:77178) antiseptic drug (Code: CHEBI:48218) anthelminthic drug (Code: CHEBI:35443) | None FDA | 1JTX 3VW1 5OV9 |
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| nadide | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) | None FDA | |
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| udenafil | Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) | a pyrazolo-pyrimidinone similar to sildenafil; phosphodiesterase type 5 inhibitor | Enzyme Inhibitors (Code: D004791) Phosphodiesterase 5 Inhibitors (Code: D058986) Phosphodiesterase Inhibitors (Code: D010726) | 2005-12-31 Korean Food and Drug Administration (KFDA) | |
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| darunavir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Pol polyprotein (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72874, gene: pol, swissprot: Q72874_9HIV1) Protease (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9YQ12, gene: protease, swissprot: Q9YQ12_9HIV1) | An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS. | Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Protease Inhibitors (Code: D017320) Protease Inhibitor (Code: N0000175889) Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Protease Inhibitors (Code: D011480) antiviral drug (Code: CHEBI:36044) | 2007-02-12 EMA 2006-06-23 FDA | 1T3R 1T7I 2F80 2F81 2F8G 2HS1 2HS2 2IDW 2IEN 2IEO 3BVB 3CYW 3D1Z 3D20 3EBZ 3EKT 3EM6 3GGU 3JVY 3JW2 3LZS 3LZU 3LZV 3MWS 3OGP 3OXW 3OY4 3PWM 3S53 3S54 3SO9 3T3C 3TKW 3TTP 3U7S 3UCB 4DQB 4DQC 4DQE 4DQF 4DQH 4HLA 4LL3 4NJT 4NPT 4Q1W 4Q1X 4Q1Y 4YOA 5E5J 5E5K 5KQY 5KR1 5T2Z |
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| lutein | A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA. | food colouring (Code: CHEBI:77182) | None FDA | |
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| testosterone propionate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) | An ester of TESTOSTERONE with a propionate substitution at the 17-beta position. | 1974-05-02 FDA | |
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| epicriptine | a sec-butyl group replaces the isobutyl group of dihydroergocryptine | None FDA | |
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| doripenem | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | has antibacterial activity; structure given in first source | Carbapenems (Code: N0000011294) Penem Antibacterial (Code: N0000175496) | 2007-10-12 FDA | |
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| liraglutide | Glucagon-like peptide 1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P43220, gene: GLP1R, swissprot: GLP1R_HUMAN) | An analog of GLUCAGON-LIKE PEPTIDE 1 and agonist of the GLUCAGON-LIKE PEPTIDE 1 RECEPTOR that is used as a HYPOGLYCEMIC AGENT and supplemental therapy in the treatment of DIABETES MELLITUS by patients who do not respond to METFORMIN. | GLP-1 Receptor Agonist (Code: N0000178480) Glucagon-Like Peptide 1 (Code: N0000170335) Glucagon-like Peptide-1 (GLP-1) Agonists (Code: N0000020058) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Hypoglycemic Agents (Code: D007004) Incretins (Code: D054795) neuroprotective agent (Code: CHEBI:63726) | 2009-06-30 EMA 2010-01-25 FDA | |
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| permethrin | Sodium channel protein (Organism: Sarcoptes scabiei type hominis, class: Ion channel, accessions: Q2VKV7, gene: vssc, swissprot: Q2VKV7_SARSC) | A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES. | Pyrethrins (Code: N0000006014) Pyrethroid (Code: N0000175847) Enzyme Inhibitors (Code: D004791) Insecticides (Code: D007306) Pesticides (Code: D010575) scabicide (Code: CHEBI:73333) pyrethroid ester insecticide (Code: CHEBI:39116) agrochemical (Code: CHEBI:33286) ectoparasiticide (Code: CHEBI:38956) | 1986-03-31 FDA | |
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| rimonabant | Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Cannabinoid receptor 2 (Organism: Mus musculus, class: GPCR, accessions: P47936, gene: Cnr2, swissprot: CNR2_MOUSE) G-protein coupled receptor 55 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y2T6, gene: GPR55, swissprot: GPR55_HUMAN) Cannabinoid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P34972, gene: CNR2, swissprot: CNR2_HUMAN) N-arachidonyl glycine receptor (Organism: Homo sapiens, class: GPCR, accessions: Q14330, gene: GPR18, swissprot: GPR18_HUMAN) Cannabinoid receptor 1 (Organism: Mus musculus, class: GPCR, accessions: P47746, gene: Cnr1, swissprot: CNR1_MOUSE) Cannabinoid receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: P20272, gene: Cnr1, swissprot: CNR1_RAT) | a potent & selective antagonist of the brain cannabinoid receptor | Cannabinoid Receptor Antagonists (Code: D063387) Cannabinoid Receptor Modulators (Code: D063385) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Neurotransmitter Agents (Code: D018377) | 2006-06-19 EMA | |
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| sodium stibogluconate | Antimony complex where the metal may exist in either the pentavalent or trivalent states. The pentavalent gluconate is used in leishmaniasis. The trivalent gluconate is most frequently used in schistosomiasis. | antineoplastic agent (Code: CHEBI:35610) antileishmanial agent (Code: CHEBI:70868) | |
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| cabazitaxel | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) | a microtubule inhibitor, cabazitaxel binds to tubulin and promotes its assembly into microtubules while simultaneously inhibiting disassembly. This leads to the stabilization of microtubules, which results in the inhibition of mitotic and interphase cellular functions | Microtubule Inhibition (Code: N0000175085) Microtubule Inhibitor (Code: N0000175592) antineoplastic agent (Code: CHEBI:35610) | 2010-06-17 FDA | |
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| edaravone | reactive chemical species (Organism: None, class: Reactive chemical species, accessions: None, gene: None, swissprot: None) | Edaravone protects neurons from oxidative stress by scavenging free radicals that may cause cellular damage, and this mechanism is expected to be effective both in patients with acute cerebral infarction and in those with ALS | 2017-05-05 FDA None PMDA | |
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| cefcapene | None | antibacterial drug (Code: CHEBI:36047) | |
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| carbocisteine | A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) mucolytic (Code: CHEBI:77034) | |
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| temsirolimus | Peptidyl-prolyl cis-trans isomerase FKBP3 (Organism: Homo sapiens, class: Enzyme, accessions: Q00688, gene: FKBP3, swissprot: FKBP3_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Serine/threonine-protein kinase mTOR (Organism: Homo sapiens, class: Kinase, accessions: P42345, gene: MTOR, swissprot: MTOR_HUMAN) Peptidyl-prolyl cis-trans isomerase FKBP1A (Organism: Homo sapiens, class: Enzyme, accessions: P62942, gene: FKBP1A, swissprot: FKB1A_HUMAN) | an inhibitor of mTOR (mammalian target of rapamycin), temsirolimus binds to an intracellular protein (FKBP-12), and the protein-drug complex inhibits the activity of mTOR that controls cell division. Inhibition of mTOR activity resulted in a G1 growth arrest in treated tumor cells | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) | 2007-11-19 EMA 2007-05-30 FDA | |
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| dexlansoprazole | Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) | The R-isomer of lansoprazole that is used to treat severe GASTROESOPHAGEAL REFLUX DISEASE. | Proton Pump Inhibitor (Code: N0000175525) Anti-Ulcer Agents (Code: D000897) Enzyme Inhibitors (Code: D004791) Gastrointestinal Agents (Code: D005765) Proton Pump Inhibitors (Code: D054328) | 2009-01-30 FDA | |
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| fampridine | Voltage-gated potassium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43525|O43526|O95259|P16389|P17658|P22001|P22459|P22460|P48547|P51787|P56696|Q03721|Q09470|Q12809|Q14003|Q14721|Q16322|Q6PIU1|Q8NCM2|Q8TAE7|Q8TDN1|Q8TDN2|Q92953|Q96KK3|Q96L42|Q96PR1|Q96RP8|Q9BQ31|Q9H252|Q9H3M0|Q9NR82|Q9NS40|Q9NSA2|Q9NZV8|Q9UIX4|Q9UJ96|Q9UK17|Q9ULD8|Q9ULS6|Q9UQ05, gene: KCNA1|KCNA10|KCNA2|KCNA3|KCNA4|KCNA5|KCNA6|KCNA7|KCNB1|KCNB2|KCNC1|KCNC2|KCNC3|KCNC4|KCND1|KCND2|KCND3|KCNF1|KCNG1|KCNG2|KCNG3|KCNG4|KCNH1|KCNH2|KCNH3|KCNH4|KCNH5|KCNH6|KCNH7|KCNH8|KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5|KCNS1|KCNS2|KCNS3|KCNV1|KCNV2, swissprot: KCA10_HUMAN|KCNA1_HUMAN|KCNA2_HUMAN|KCNA3_HUMAN|KCNA4_HUMAN|KCNA5_HUMAN|KCNA6_HUMAN|KCNA7_HUMAN|KCNB1_HUMAN|KCNB2_HUMAN|KCNC1_HUMAN|KCNC2_HUMAN|KCNC3_HUMAN|KCNC4_HUMAN|KCND1_HUMAN|KCND2_HUMAN|KCND3_HUMAN|KCNF1_HUMAN|KCNG1_HUMAN|KCNG2_HUMAN|KCNG3_HUMAN|KCNG4_HUMAN|KCNH1_HUMAN|KCNH2_HUMAN|KCNH3_HUMAN|KCNH4_HUMAN|KCNH5_HUMAN|KCNH6_HUMAN|KCNH7_HUMAN|KCNH8_HUMAN|KCNQ1_HUMAN|KCNQ2_HUMAN|KCNQ3_HUMAN|KCNQ4_HUMAN|KCNQ5_HUMAN|KCNS1_HUMAN|KCNS2_HUMAN|KCNS3_HUMAN|KCNV1_HUMAN|KCNV2_HUMAN) Potassium voltage-gated channel subfamily C member 1 (Organism: Mus musculus, class: Unclassified, accessions: P15388, gene: Kcnc1, swissprot: KCNC1_MOUSE) Potassium voltage-gated channel subfamily C member 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P22462, gene: Kcnc2, swissprot: KCNC2_RAT) | One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes. | Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Potassium Channel Blocker (Code: N0000192795) Potassium Channel Antagonists (Code: N0000175448) Potassium Channel Blockers (Code: D026902) orphan drug (Code: CHEBI:71031) avicide (Code: CHEBI:33289) | 2010-01-22 FDA | 1AEG 3RXF |
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| methyldopate | Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) | None | 1962-12-20 FDA | |
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| alcaftadine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | an H1 histamine receptor antagonist and inhibitor of the release of histamine from mast cells indicated for the prevention of itching associated with allergic conjunctivitis | Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Histamine H1 Antagonists (Code: D006634) Neurotransmitter Agents (Code: D018377) Histamine H1 Receptor Antagonists (Code: N0000000190) Histamine-1 Receptor Antagonist (Code: N0000175587) H1-receptor antagonist (Code: CHEBI:37955) anti-allergic agent (Code: CHEBI:50857) | 2010-07-28 FDA | |
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| ulipristal | Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) | a selective progesterone receptor modulator with antagonistic and partial agonistic effects, delays of ovulation for emergency contraception | Progesterone Agonist/Antagonist (Code: N0000191263) Selective Progesterone Receptor Modulators (Code: N0000191262) Contraceptive Agents (Code: D003270) Contraceptive Agents, Female (Code: D003271) Reproductive Control Agents (Code: D012102) contraceptive drug (Code: CHEBI:49323) progesterone receptor modulator (Code: CHEBI:71027) | 2009-05-15 EMA 2010-08-13 FDA | 4OAR |
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| fingolimod | Sphingosine 1-phosphate receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: Q99500, gene: S1PR3, swissprot: S1PR3_HUMAN) Sphingosine 1-phosphate receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: Q9H228, gene: S1PR5, swissprot: S1PR5_HUMAN) Sphingosine-1-phosphate lyase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O95470, gene: SGPL1, swissprot: SGPL1_HUMAN) Sphingosine 1-phosphate receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: O95977, gene: S1PR4, swissprot: S1PR4_HUMAN) Sphingosine 1-phosphate receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21453, gene: S1PR1, swissprot: S1PR1_HUMAN) Transient receptor potential cation channel subfamily M member 7 (Organism: Mus musculus, class: Unclassified, accessions: Q923J1, gene: Trpm7, swissprot: TRPM7_MOUSE) | A sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS. | Sphingosine 1-Phosphate Receptor Modulators (Code: N0000181815) Sphingosine 1-phosphate Receptor Modulator (Code: N0000181816) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) prodrug (Code: CHEBI:50266) | 2010-09-21 FDA | |
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| lurasidone | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | A thiazole derivative and atypical ANTIPSYCHOTIC AGENT that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST; SEROTONIN 5-HT2 RECEPTOR ANTAGONIST, serotonin 5-HT7 receptor antagonist, and antagonist of the adrenergic alpha-2A and alpha-2C receptors, as well as a partial SEROTONIN 5-HT1A RECEPTOR AGONIST. It is used in the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER. | Atypical Antipsychotic (Code: N0000175430) Adrenergic Agents (Code: D018663) Adrenergic alpha-2 Receptor Antagonists (Code: D058669) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Dopamine D2 Receptor Antagonists (Code: D065127) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin 5-HT2 Receptor Antagonists (Code: D058830) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) adrenergic antagonist (Code: CHEBI:37887) dopaminergic antagonist (Code: CHEBI:48561) serotonergic antagonist (Code: CHEBI:48279) second generation antipsychotic (Code: CHEBI:65191) | 2010-10-28 FDA | |
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| ceftaroline fosamil | Bacterial penicillin-binding protein (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P02918|P02919|P08506|P0AD65|P0AD68|P0AEB2|P24228, gene: dacA|dacB|dacC|ftsI|mrcA|mrcB|mrdA, swissprot: DACA_ECOLI|DACB_ECOLI|DACC_ECOLI|FTSI_ECOLI|PBP2_ECOLI|PBPA_ECOLI|PBPB_ECOLI) | an N-phosphono water-soluble prodrug of T-91825; broad-spectrum activity, including beta-lactam-resistant Streptococcus; do not confuse with TAK-559 | Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) prodrug (Code: CHEBI:50266) antibacterial drug (Code: CHEBI:36047) | 2010-10-29 FDA | |
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| droxypropine | None | |
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| eribulin | Tubulin beta (Organism: Homo sapiens, class: Structural, accessions: P04350|P07437|P68371|Q13509|Q13885|Q3ZCM7|Q9BUF5|Q9BVA1|Q9H4B7, gene: TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8, swissprot: TBB1_HUMAN|TBB2A_HUMAN|TBB2B_HUMAN|TBB3_HUMAN|TBB4A_HUMAN|TBB4B_HUMAN|TBB5_HUMAN|TBB6_HUMAN|TBB8_HUMAN) | a halichondrin B derivative that suppresses microtubule growth and acts as an antimitotic agent | Microtubule Inhibition (Code: N0000175085) Microtubule Inhibitor (Code: N0000175592) antineoplastic agent (Code: CHEBI:35610) | 2011-03-17 EMA 2010-11-15 FDA | 5JH7 |
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| boceprevir | Hepatitis C virus serine protease, NS3/NS4A (Organism: Hepatitis C virus, class: Enzyme, accessions: A3EZI9|D2K2A8, gene: NS3|NS4A, swissprot: A3EZI9_9HEPC|D2K2A8_9HEPC) Lysosomal protective protein (Organism: Homo sapiens, class: Enzyme, accessions: P10619, gene: CTSA, swissprot: PPGB_HUMAN) Cathepsin F (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBX1, gene: CTSF, swissprot: CATF_HUMAN) Cathepsin K (Organism: Homo sapiens, class: Enzyme, accessions: P43235, gene: CTSK, swissprot: CATK_HUMAN) Cathepsin B (Organism: Homo sapiens, class: Enzyme, accessions: P07858, gene: CTSB, swissprot: CATB_HUMAN) Cathepsin L2 (Organism: Homo sapiens, class: Enzyme, accessions: O60911, gene: CTSV, swissprot: CATL2_HUMAN) Neutrophil elastase (Organism: Homo sapiens, class: Enzyme, accessions: P08246, gene: ELANE, swissprot: ELNE_HUMAN) Chymase (Organism: Homo sapiens, class: Enzyme, accessions: P23946, gene: CMA1, swissprot: CMA1_HUMAN) Cathepsin S (Organism: Homo sapiens, class: Enzyme, accessions: P25774, gene: CTSS, swissprot: CATS_HUMAN) Cathepsin L1 (Organism: Homo sapiens, class: Enzyme, accessions: P07711, gene: CTSL, swissprot: CATL1_HUMAN) Nonstructural protein NS3-4A (Organism: Hepatitis C virus, class: Unclassified, accessions: A0A0K1CY61, gene: None, swissprot: A0A0K1CY61_9HEPC) | Boceprevir is an inhibitor of the HCV NS3/4A protease that is necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS4A, NS4B, NS5A and NS5B proteins. Boceprevir covalently, yet reversibly, binds to the NS3 protease active site serine (S139) through an (alpha)-ketoamide functional group to inhibit viral replication in HCV-infected host cells. In a biochemical assay, boceprevir inhibited the activity of recombinant HCV genotype 1a and 1b NS3/4A protease enzymes, with Ki values of 14 nM for each subtype. | HCV NS3/4A Protease Inhibitors (Code: N0000182638) Hepatitis C Virus NS3/4A Protease Inhibitor (Code: N0000182639) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A5 Inhibitors (Code: N0000190115) antiviral drug (Code: CHEBI:36044) | 2011-05-13 FDA | 2OC8 |
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| telaprevir | Lysosomal protective protein (Organism: Homo sapiens, class: Enzyme, accessions: P10619, gene: CTSA, swissprot: PPGB_HUMAN) Cathepsin S (Organism: Homo sapiens, class: Enzyme, accessions: P25774, gene: CTSS, swissprot: CATS_HUMAN) Cathepsin L1 (Organism: Homo sapiens, class: Enzyme, accessions: P07711, gene: CTSL, swissprot: CATL1_HUMAN) Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) Cathepsin K (Organism: Homo sapiens, class: Enzyme, accessions: P43235, gene: CTSK, swissprot: CATK_HUMAN) Cathepsin B (Organism: Homo sapiens, class: Enzyme, accessions: P07858, gene: CTSB, swissprot: CATB_HUMAN) Cathepsin L2 (Organism: Homo sapiens, class: Enzyme, accessions: O60911, gene: CTSV, swissprot: CATL2_HUMAN) Chymotrypsin-like elastase family member 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UNI1, gene: CELA1, swissprot: CELA1_HUMAN) Neutrophil elastase (Organism: Homo sapiens, class: Enzyme, accessions: P08246, gene: ELANE, swissprot: ELNE_HUMAN) Chymase (Organism: Homo sapiens, class: Enzyme, accessions: P23946, gene: CMA1, swissprot: CMA1_HUMAN) Hepatitis C virus serine protease, NS3/NS4A (Organism: Hepatitis C virus, class: Enzyme, accessions: A3EZI9|D2K2A8, gene: NS3|NS4A, swissprot: A3EZI9_9HEPC|D2K2A8_9HEPC) | a hepatitis C virus serine protease inhibitor | HCV NS3/4A Protease Inhibitors (Code: N0000182638) Hepatitis C Virus NS3/4A Protease Inhibitor (Code: N0000182639) Cytochrome P450 3A Inhibitors (Code: N0000190114) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 2B1 Inhibitors (Code: N0000190109) antiviral drug (Code: CHEBI:36044) | 2011-09-19 EMA 2011-05-23 FDA | |
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| rilpivirine | Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) | A diarylpyrimidine derivative and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 that is used in the treatment of HIV INFECTIONS. It is also used in combination with other ANTI-HIV AGENTS, since ANTIVIRAL DRUG RESISTANCE emerges rapidly when it is used alone. | Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175463) Non-Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009948) Non-Nucleoside Analog (Code: N0000175460) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) | 2011-05-20 FDA | 2ZD1 2ZE2 3BGR 3MEE 3MEG 3QLH 4G1Q 4ICL 4ID5 4IDK 4IFV 4IFY 4IG3 4KFB 5CYM 5CYQ 6ELI |
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| ivacaftor | Cystic fibrosis transmembrane conductance regulator (Organism: Homo sapiens, class: Ion channel, accessions: P13569, gene: CFTR, swissprot: CFTR_HUMAN) | Ivacaftor is a potentiator of the CFTR protein. The CFTR protein is a chloride channel present at the surface of epithelial cells in multiple organs. Ivacaftor facilitates increased chloride transport by potentiating the channel-open probability (or gating) of the CFTR protein. | Chloride Channel Agonists (Code: D065101) Membrane Transport Modulators (Code: D049990) Cystic Fibrosis Transmembrane Conductance Regulator Potentiator (Code: N0000184146) Chloride Channel Activation Potentiators (Code: N0000184145) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 3A Inhibitors (Code: N0000190114) orphan drug (Code: CHEBI:71031) | 2012-01-31 FDA | |
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| linagliptin | Prolyl endopeptidase FAP (Organism: Homo sapiens, class: Enzyme, accessions: Q12884, gene: FAP, swissprot: SEPR_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Prolyl endopeptidase FAP (Organism: Mus musculus, class: Enzyme, accessions: P97321, gene: Fap, swissprot: SEPR_MOUSE) Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) | A purine and quinazoline derivative that functions as an INCRETIN and DIPEPTIDYL-PEPTIDASE IV INHIBTOR. It is used as a HYPOGLYCEMIC AGENT in the treatment of TYPE II DIABETES MELLITUS. | Dipeptidyl Peptidase 4 Inhibitors (Code: N0000175912) Dipeptidyl Peptidase 4 Inhibitor (Code: N0000175913) Dipeptidyl-Peptidase IV Inhibitors (Code: D054873) Enzyme Inhibitors (Code: D004791) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Hypoglycemic Agents (Code: D007004) Incretins (Code: D054795) Protease Inhibitors (Code: D011480) hypoglycemic agent (Code: CHEBI:35526) | 2011-05-02 FDA | 2RGU |
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| abiraterone acetate | Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN) Steroid 17-alpha-hydroxylase/17,20 lyase (Organism: Homo sapiens, class: Enzyme, accessions: P05093, gene: CYP17A1, swissprot: CP17A_HUMAN) Cytochrome P450 17A1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P11715, gene: Cyp17a1, swissprot: CP17A_RAT) | An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER. | Cytochrome P450 17A1 Inhibitors (Code: N0000182632) Cytochrome P450 17A1 Inhibitor (Code: N0000182633) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Antineoplastic Agents (Code: D000970) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Metabolic Side Effects of Drugs and Substances (Code: D065606) Steroid Synthesis Inhibitors (Code: D065088) prodrug (Code: CHEBI:50266) antineoplastic agent (Code: CHEBI:35610) | 2011-09-05 EMA 2011-04-28 FDA | |
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| gabapentin enacarbil | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Homo sapiens, class: Ion channel, accessions: P54289, gene: CACNA2D1, swissprot: CA2D1_HUMAN) Voltage-dependent calcium channel subunit alpha-2/delta-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY47, gene: CACNA2D2, swissprot: CA2D2_HUMAN) | Gabapentin enacarbil is a prodrug of gabapentin and, accordingly, its therapeutic effects in restless legs syndrome and postherpetic neuralgia are attributable to gabapentin. In animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). | prodrug (Code: CHEBI:50266) anticonvulsant (Code: CHEBI:35623) | 2011-04-06 FDA | |
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| vandetanib | Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Tubulin alpha-1A chain (Organism: Rattus norvegicus, class: Structural, accessions: P68370, gene: Tuba1a, swissprot: TBA1A_RAT) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) AarF domain-containing protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96D53, gene: COQ8B, swissprot: COQ8B_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) Serine/threonine-protein kinase MRCK alpha (Organism: Homo sapiens, class: Kinase, accessions: Q5VT25, gene: CDC42BPA, swissprot: MRCKA_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Chaperone activity of bc1 complex-like, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q8NI60, gene: COQ8A, swissprot: COQ8A_HUMAN) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) Macrophage-stimulating protein receptor (Organism: Homo sapiens, class: Kinase, accessions: Q04912, gene: MST1R, swissprot: RON_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Ephrin type-A receptor 7 (Organism: Homo sapiens, class: Kinase, accessions: Q15375, gene: EPHA7, swissprot: EPHA7_HUMAN) Protein-tyrosine kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q13882, gene: PTK6, swissprot: PTK6_HUMAN) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) Dual specificity testis-specific protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q15569, gene: TESK1, swissprot: TESK1_HUMAN) Activin receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: Q04771, gene: ACVR1, swissprot: ACVR1_HUMAN) Serine/threonine-protein kinase MRCK gamma (Organism: Homo sapiens, class: Kinase, accessions: Q6DT37, gene: CDC42BPG, swissprot: MRCKG_HUMAN) Serine/threonine-protein kinase MRCK beta (Organism: Homo sapiens, class: Kinase, accessions: Q9Y5S2, gene: CDC42BPB, swissprot: MRCKB_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Tyrosine-protein kinase Srms (Organism: Homo sapiens, class: Kinase, accessions: Q9H3Y6, gene: SRMS, swissprot: SRMS_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Serine/threonine-protein kinase 32A (Organism: Homo sapiens, class: Kinase, accessions: Q8WU08, gene: STK32A, swissprot: ST32A_HUMAN) Serine/threonine-protein kinase SIK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2K2, gene: SIK3, swissprot: SIK3_HUMAN) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) Hormonally up-regulated neu tumor-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: P57058, gene: HUNK, swissprot: HUNK_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Mitogen-activated protein kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q16659, gene: MAPK6, swissprot: MK06_HUMAN) Serine/threonine-protein kinase receptor R3 (Organism: Homo sapiens, class: Kinase, accessions: P37023, gene: ACVRL1, swissprot: ACVL1_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) Ephrin type-B receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29323, gene: EPHB2, swissprot: EPHB2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) | inhibits the tyrosine kinase activity involved in both normal cellular function and pathologic processes such as oncogenesis, metastasis, tumor angiogenesis, and maintenance of the tumor microenvironment | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) antineoplastic agent (Code: CHEBI:35610) | 2011-04-06 FDA | 2IVU |
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| fidaxomicin | DNA-directed RNA polymerase (Organism: Peptoclostridium difficile (strain 630), class: Enzyme, accessions: Q182S6|Q18CF1|Q18CF3|Q18CI5, gene: rpoA|rpoB|rpoC|rpoZ, swissprot: RPOA_PEPD6|RPOB_PEPD6|RPOC_PEPD6|RPOZ_PEPD6) | antibiotic from strain of Actinoplanes which inhibits nucleic acid polymerases; Rn given refers to lipiarmycin A3 | Macrolides (Code: N0000007529) Macrolide Antibacterial (Code: N0000175431) antibacterial drug (Code: CHEBI:36047) | 2011-05-27 FDA | |
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| retigabine | Potassium voltage-gated channel subfamily KQT member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O43526, gene: KCNQ2, swissprot: KCNQ2_HUMAN) Potassium voltage-gated channel subfamily KQT member 4 (Organism: Homo sapiens, class: Ion channel, accessions: P56696, gene: KCNQ4, swissprot: KCNQ4_HUMAN) Potassium voltage-gated channel subfamily KQT member 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NR82, gene: KCNQ5, swissprot: KCNQ5_HUMAN) Potassium voltage-gated channel subfamily KQT member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O43525, gene: KCNQ3, swissprot: KCNQ3_HUMAN) Potassium voltage-gated channel subfamily KQT member 2 (Organism: Mus musculus, class: Ion channel, accessions: Q9Z351, gene: Kcnq2, swissprot: KCNQ2_MOUSE) | In vitro studies indicate that ezogabine enhances transmembrane potassium currents mediated by the KCNQ (Kv7.2 to 7.5) family of ion channels. By activating KCNQ channels, ezogabine is thought to stabilize the resting membrane potential and reduce brain excitability. | Potassium Channel Openers (Code: N0000182728) Potassium Channel Opener (Code: N0000182729) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) anticonvulsant (Code: CHEBI:35623) | 2011-03-28 EMA 2011-06-10 FDA | |
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| rivaroxaban | Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) Suppressor of tumorigenicity 14 protein (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y5Y6, gene: ST14, swissprot: ST14_HUMAN) Coagulation factor X (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: O19045, gene: F10, swissprot: FA10_RABIT) | A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME. | Factor Xa Inhibitor (Code: N0000175637) Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Factor Xa Inhibitors (Code: D065427) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) | 2011-07-01 FDA | 2W26 |
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| indacaterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) | Indacaterol is a long-acting beta2-adrenergic agonist. The pharmacological effects of beta2-adrenoceptor agonist drugs, including indacaterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cyclic monophosphate). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle. | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) | 2011-07-01 FDA | |
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| ticagrelor | P2Y purinoceptor 12 (Organism: Homo sapiens, class: GPCR, accessions: Q9H244, gene: P2RY12, swissprot: P2Y12_HUMAN) P2Y purinoceptor 12 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q9EPX4, gene: P2ry12, swissprot: P2Y12_RAT) Equilibrative nucleoside transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: Q99808, gene: SLC29A1, swissprot: S29A1_HUMAN) | a cyclopentyltriazolopyrimidine, inhibitor of platelet activation and aggregation mediated by the P2Y12 ADP-receptor indicated to reduce the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction | P2Y12 Platelet Inhibitor (Code: N0000182142) Phenylalanine Hydroxylase Activators (Code: N0000190482) Decreased Platelet Aggregation (Code: N0000008832) P2Y12 Receptor Antagonists (Code: N0000182143) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Cytochrome P450 3A5 Inhibitors (Code: N0000190115) P-Glycoprotein Inhibitors (Code: N0000185503) Neurotransmitter Agents (Code: D018377) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P2 Receptor Antagonists (Code: D058919) Purinergic P2Y Receptor Antagonists (Code: D058921) platelet aggregation inhibitor (Code: CHEBI:50427) | 2011-07-20 FDA | 5ALB 5ALC |
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| vemurafenib | RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) Serine/threonine-protein kinase A-Raf (Organism: Homo sapiens, class: Kinase, accessions: P10398, gene: ARAF, swissprot: ARAF_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) | analog of PLX4720; a specific inhibitor of Raf protein kinases; used for tretment of metastatic melanoma | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Cytochrome P450 1A2 Inhibitors (Code: N0000182138) P-Glycoprotein Inhibitors (Code: N0000185503) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) antineoplastic agent (Code: CHEBI:35610) | 2011-08-17 FDA | 3OG7 4RZV 5HES |
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| vismodegib | Sonic hedgehog protein (Organism: Homo sapiens, class: Enzyme, accessions: Q15465, gene: SHH, swissprot: SHH_HUMAN) Sonic hedgehog protein (Organism: Mus musculus, class: Enzyme, accessions: Q62226, gene: Shh, swissprot: SHH_MOUSE) Smoothened homolog (Organism: Homo sapiens, class: GPCR, accessions: Q99835, gene: SMO, swissprot: SMO_HUMAN) Smoothened homolog (Organism: Mus musculus, class: GPCR, accessions: P56726, gene: Smo, swissprot: SMO_MOUSE) | inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity | Hedgehog Pathway Inhibitor (Code: N0000184149) Smoothened Receptor Antagonists (Code: N0000184148) antineoplastic agent (Code: CHEBI:35610) | 2013-07-12 EMA 2012-01-30 FDA | 5L7I |
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| sugammadex | a reversal agent for neuromuscular blocker rocuronium bromide | gamma-Cyclodextrins (Code: N0000168522) neuromuscular agent (Code: CHEBI:51372) | 2015-12-15 FDA | |
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| threonine | An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins. | None FDA | |
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| alanine | A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM. | Amino Acid (Code: N0000175780) Amino Acids (Code: N0000006806) | None FDA | |
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| bismuth subsalicylate | Cyclooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P23219|P35354, gene: PTGS1|PTGS2, swissprot: PGH1_HUMAN|PGH2_HUMAN) | bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter | Bismuth (Code: N0000007888) Antidiarrheals (Code: D000930) Gastrointestinal Agents (Code: D005765) | 1996-08-15 FDA | |
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| thymol | Transient receptor potential cation channel subfamily M member 8 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q8R455, gene: Trpm8, swissprot: TRPM8_RAT) Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) | A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent. It was formerly used as a vermifuge. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antifungal Agents (Code: D000935) | None FDA | 1E06 |
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| cineole | 1,4-cineole is also available; solvent for gutta-percha; main constituent of oil of Eucalyptus (ingalipt) | Anti-Infective Agents (Code: D000890) Solvents (Code: D012997) flavouring agent (Code: CHEBI:35617) | None FDA | 1T2B 3BE0 4FMX 4FYZ 4L6G 4L77 4LHT |
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| carbamide | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | flour treatment agent (Code: CHEBI:64577) fertilizer (Code: CHEBI:33287) | 1966-10-05 FDA | |
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| phenol | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Endolysin (Organism: Enterobacteria phage T4, class: Enzyme, accessions: P00720, gene: E, swissprot: ENLYS_BPT4) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase (Organism: Dicentrarchus labrax, class: Unclassified, accessions: Q2PCB5, gene: ca, swissprot: Q2PCB5_DICLA) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) | An antiseptic and disinfectant aromatic alcohol. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Cardiovascular Agents (Code: D002317) Disinfectants (Code: D004202) Pharmaceutical Solutions (Code: D019999) Sclerosing Solutions (Code: D012597) antiseptic drug (Code: CHEBI:48218) | None FDA | |
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| allantoin | A urea hydantoin that is found in URINE and PLANTS and is used in dermatological preparations. | Dermatologic Agents (Code: D003879) vulnerary (Code: CHEBI:73336) | None FDA | 2Q37 |
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| Padimate O | None | None FDA | |
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| hydroxyproline | A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. | None FDA | |
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| piperonyl butoxide | Cytochrome P450 (Organism: Pediculus humanus subsp. corporis, class: Enzyme, accessions: E0V9R7|E0VAD1|E0VBK5|E0VCA5|E0VCW8|E0VCW9|E0VDM3|E0VDR0|E0VED4|E0VGV6|E0VHL8|E0VHZ1|E0VJJ0|E0VM29|E0VMV6|E0VMV7|E0VMW9|E0VQ45|E0VQ46|E0VQ47|E0VRD2|E0VSD4|E0VSD5|E0VUR0|E0VUR1|E0VV39|E0VV52|E0VV70|E0VV72|E0VXT9|E0VZW4|E0W115|E0W2B1|E0W389|E0W4F7, gene: None, swissprot: E0V9R7_PEDHC|E0VAD1_PEDHC|E0VBK5_PEDHC|E0VCA5_PEDHC|E0VCW8_PEDHC|E0VCW9_PEDHC|E0VDM3_PEDHC|E0VDR0_PEDHC|E0VED4_PEDHC|E0VGV6_PEDHC|E0VHL8_PEDHC|E0VHZ1_PEDHC|E0VJJ0_PEDHC|E0VM29_PEDHC|E0VMV6_PEDHC|E0VMV7_PEDHC|E0VMW9_PEDHC|E0VQ45_PEDHC|E0VQ46_PEDHC|E0VQ47_PEDHC|E0VRD2_PEDHC|E0VSD4_PEDHC|E0VSD5_PEDHC|E0VUR0_PEDHC|E0VUR1_PEDHC|E0VV39_PEDHC|E0VV52_PEDHC|E0VV70_PEDHC|E0VV72_PEDHC|E0VXT9_PEDHC|E0VZW4_PEDHC|E0W115_PEDHC|E0W2B1_PEDHC|E0W389_PEDHC|E0W4F7_PEDHC) | An insecticide synergist, especially for pyrethroids and ROTENONE. | Pesticide Synergists (Code: D010574) Pesticides (Code: D010575) pesticide synergist (Code: CHEBI:25943) | 2000-03-07 FDA | |
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| tocofersolan | A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture. | Antioxidants (Code: D000975) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Protective Agents (Code: D020011) Vitamins (Code: D014815) | None FDA | 1OIP 1R5L 3W67 3W68 5MUE 5MUG |
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| tapentadol | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) | None | Opioid Agonist (Code: N0000175690) Opioid Agonists (Code: N0000000174) | 2008-11-20 FDA | |
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| Florbetapir F-18 | Amyloid beta A4 protein (Organism: Homo sapiens, class: Unclassified, accessions: P05067, gene: APP, swissprot: A4_HUMAN) | a PET agent for Abeta plaques | Radioactive Diagnostic Agent (Code: N0000177914) Positron Emitting Activity (Code: N0000175869) | 2012-04-06 FDA | |
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| doconexent | Free fatty acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: O14842, gene: FFAR1, swissprot: FFAR1_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Oxoeicosanoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS5, gene: OXER1, swissprot: OXER1_HUMAN) Transient receptor potential cation channel subfamily A member 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q6RI86, gene: Trpa1, swissprot: TRPA1_RAT) | a mixture of fish oil and primrose oil; used as a high-docosahexaenoic acid fatty acid supplement | nutraceutical (Code: CHEBI:50733) antineoplastic agent (Code: CHEBI:35610) | None FDA | 1FDQ 1MV9 2BYO 2G7Z 2VV0 3HS7 5J0Z |
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| enzacamene | camphor derivative used as sunscreen | None FDA | |
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| sincalide | Cholecystokinin receptor type A (Organism: Homo sapiens, class: GPCR, accessions: P32238, gene: CCKAR, swissprot: CCKAR_HUMAN) Cholecystokinin receptor type A (Organism: Cavia porcellus, class: GPCR, accessions: Q63931, gene: CCKAR, swissprot: CCKAR_CAVPO) Gastrin/cholecystokinin type B receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30553, gene: Cckbr, swissprot: GASR_RAT) Cholecystokinin receptor (Organism: Mus musculus, class: GPCR, accessions: O08786|P56481, gene: Cckar|Cckbr, swissprot: CCKAR_MOUSE|GASR_MOUSE) Cholecystokinin receptor type A (Organism: Rattus norvegicus, class: GPCR, accessions: P30551, gene: Cckar, swissprot: CCKAR_RAT) Gastrin/cholecystokinin type B receptor (Organism: Homo sapiens, class: GPCR, accessions: P32239, gene: CCKBR, swissprot: GASR_HUMAN) Gastrin/cholecystokinin type B receptor (Organism: Mus musculus, class: GPCR, accessions: P56481, gene: Cckbr, swissprot: GASR_MOUSE) | An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas. | Cholecystokinin (Code: N0000007750) Cholecystokinin Analog (Code: N0000175798) | 1976-07-21 FDA | |
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| apixaban | Prothrombin (Organism: Homo sapiens, class: Enzyme, accessions: P00734, gene: F2, swissprot: THRB_HUMAN) Coagulation factor X (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: O19045, gene: F10, swissprot: FA10_RABIT) Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) | Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development. | Factor Xa Inhibitor (Code: N0000175637) Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Factor Xa Inhibitors (Code: D065427) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) | 2011-05-18 EMA 2012-12-28 FDA | 2P16 |
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| cobicistat | Cytochrome P450 3A (Organism: Homo sapiens, class: Enzyme, accessions: P08684|P20815|P24462|Q9HB55, gene: CYP3A4|CYP3A43|CYP3A5|CYP3A7, swissprot: CP343_HUMAN|CP3A4_HUMAN|CP3A5_HUMAN|CP3A7_HUMAN) | A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS. | Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 3A Inhibitor (Code: N0000191001) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Cytochrome P-450 CYP3A Inhibitors (Code: D065692) Cytochrome P-450 Enzyme Inhibitors (Code: D065607) Enzyme Inhibitors (Code: D004791) Metabolic Side Effects of Drugs and Substances (Code: D065606) | 2012-08-27 FDA | |
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| elvitegravir | Gag-Pol polyprotein (Organism: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI), class: Polyprotein, accessions: P03367, gene: gag-pol, swissprot: POL_HV1BR) Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) | Elvitegravir inhibits the strand transfer activity of HIV-1 integrase (integrase strand transfer inhibitor; INSTI), an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the viral infection. Elvitegravir does not inhibit human topoisomerases I or II. | HIV Integrase Inhibitors (Code: N0000000127) Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor (Code: N0000175887) Cytochrome P450 2C9 Inducers (Code: N0000185507) | 2012-08-27 FDA | 3L2U 3L2W |
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| Flutemetamol (18F) | used for PET imaging of brain fibrillar amyloid beta | Radioactive Diagnostic Agent (Code: N0000177914) Radiopharmaceutical Activity (Code: N0000000205) | 2013-10-25 FDA | |
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| glycopyrronium bromide | Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | Glycopyrrolate is a long-acting muscarinic antagonist, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation. The competitive and reversible nature of antagonism was shown with human and animal origin receptors and isolated organ preparations. In preclinical in vitro as well as in vivo studies, prevention of methacholine and acetylcholine induced bronchoconstrictive effects was dose-dependent and lasted longer than 24 hours. The clinical relevance of these findings is unknown. The bronchodilation following inhalation of glycopyrrolate is predominantly a site-specific effect. | Anticholinergic (Code: N0000175574) Adjuvants, Anesthesia (Code: D000759) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Muscarinic Antagonists (Code: D018727) Neurotransmitter Agents (Code: D018377) | 1961-08-11 FDA | |
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| eslicarbazepine acetate | Sodium channel alpha subunit (Organism: Homo sapiens, class: Ion channel, accessions: P35498|P35499|Q01118|Q14524|Q15858|Q99250|Q9NY46|Q9UI33|Q9UQD0|Q9Y5Y9, gene: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN|SCN4A_HUMAN|SCN5A_HUMAN|SCN7A_HUMAN|SCN8A_HUMAN|SCN9A_HUMAN|SCNAA_HUMAN|SCNBA_HUMAN) | Eslicarbazepine acetate is extensively converted to eslicarbazepine, which is considered to be responsible for therapeutic effects in humans. The precise mechanism(s) by which eslicarbazepine exerts anticonvulsant activity is unknown but is thought to involve inhibition of voltage-gated sodium channels. | Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) | 2013-11-08 FDA | |
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| avanafil | cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Organism: Homo sapiens, class: Enzyme, accessions: P51160, gene: PDE6C, swissprot: PDE6C_HUMAN) cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Canis familiaris, class: Enzyme, accessions: O77746, gene: PDE5A, swissprot: PDE5A_CANFA) | a selective inhibitor of cGMP-specific PDE5 has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP in the corpus cavernosum | Phosphodiesterase 5 Inhibitor (Code: N0000175599) Phosphodiesterase 5 Inhibitors (Code: N0000020026) vasodilator agent (Code: CHEBI:35620) | 2013-06-21 EMA 2012-04-27 FDA | |
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| DL-Alanine | None | |
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| lasofoxifene | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06211|Q62986, gene: Esr1|Esr2, swissprot: ESR1_RAT|ESR2_RAT) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) | a SERM whose biological actions are largely mediated through binding to estrogen receptors, this binding results in the activation of some estrogenic pathways and a blockade of others, Lasofoxifene produces tissue and cell-specific effects in estrogen-responsive tissues | 2009-02-24 EMA | 2OUZ |
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| lacosamide | Dihydropyrimidinase-related protein 2 (Organism: Homo sapiens, class: Unclassified, accessions: Q16555, gene: DPYSL2, swissprot: DPYL2_HUMAN) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) Sodium channel protein type X alpha subunit (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62968, gene: Scn10a, swissprot: SCNAA_RAT) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) Sodium channel protein type 3 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P08104, gene: Scn3a, swissprot: SCN3A_RAT) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) Sodium channel protein type 2 subunit alpha (Organism: Rattus norvegicus, class: Ion channel, accessions: P04775, gene: Scn2a, swissprot: SCN2A_RAT) | a functionalized amino acid, selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing, indicated for partial-onset seizures | Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) | 2008-08-29 EMA 2008-10-28 FDA | |
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| olaflur | cariostatic agent | Cariostatic Agents (Code: D002327) Protective Agents (Code: D020011) | |
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| 4-dimethylaminophenol | in combination with SODIUM NITRITE antagonizes experimental cyanide poisoning; RN given refers to parent cpd | Antidotes (Code: D000931) Protective Agents (Code: D020011) | |
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| aceclidine | Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) | cholinomimetic used to reduce intraocular pressure in glaucoma | Autonomic Agents (Code: D001337) Miotics (Code: D008916) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) | |
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| afatinib | Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92630, gene: DYRK2, swissprot: DYRK2_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BUB5, gene: MKNK1, swissprot: MKNK1_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Organism: Homo sapiens, class: Kinase, accessions: Q9Y463, gene: DYRK1B, swissprot: DYR1B_HUMAN) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) | a radiation sensitizing agent and an ErbB2 tyrosine kinase inhibitor | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Radiation-Sensitizing Agents (Code: D011838) antineoplastic agent (Code: CHEBI:35610) | 2013-09-25 EMA 2013-07-12 FDA | 4G5J |
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| alanyl glutamine | None | |
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| azilsartan medoxomil | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) Type-1 angiotensin II receptor (Organism: Bos taurus, class: GPCR, accessions: P25104, gene: AGTR1, swissprot: AGTR1_BOVIN) | an angiotensin type 1 receptor blocker; receptor blocker | Angiotensin 2 Type 1 Receptor Antagonists (Code: N0000180999) Angiotensin 2 Receptor Blocker (Code: N0000175561) Decreased Blood Pressure (Code: N0000178477) Angiotensin II Type 1 Receptor Blockers (Code: D047228) Angiotensin Receptor Antagonists (Code: D057911) prodrug (Code: CHEBI:50266) angiotensin receptor antagonist (Code: CHEBI:61016) antihypertensive agent (Code: CHEBI:35674) | 2011-02-25 FDA | |
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| laropiprant | Prostaglandin D2 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q13258, gene: PTGDR, swissprot: PD2R_HUMAN) Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostaglandin E2 receptor EP2 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43116, gene: PTGER2, swissprot: PE2R2_HUMAN) Prostaglandin E2 receptor EP3 subtype (Organism: Homo sapiens, class: GPCR, accessions: P43115, gene: PTGER3, swissprot: PE2R3_HUMAN) Prostaglandin D2 receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5Y4, gene: PTGDR2, swissprot: PD2R2_HUMAN) Thromboxane A2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P21731, gene: TBXA2R, swissprot: TA2R_HUMAN) Prostaglandin E2 receptor EP1 subtype (Organism: Homo sapiens, class: GPCR, accessions: P34995, gene: PTGER1, swissprot: PE2R1_HUMAN) | a potent orally active human prostaglandin D(2) receptor 1 antagonist | |
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| (2-benzhydryloxyethyl)diethyl-methylammonium iodide | None | |
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| 2-(4-chlorphenoxy)-ethanol | None | |
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| pasireotide | Somatostatin receptor type 3 (Organism: Homo sapiens, class: GPCR, accessions: P32745, gene: SSTR3, swissprot: SSR3_HUMAN) Somatostatin receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: P30872, gene: SSTR1, swissprot: SSR1_HUMAN) Somatostatin receptor type 5 (Organism: Homo sapiens, class: GPCR, accessions: P35346, gene: SSTR5, swissprot: SSR5_HUMAN) Somatostatin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P30874, gene: SSTR2, swissprot: SSR2_HUMAN) Somatostatin receptor type 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P30680, gene: Sstr2, swissprot: SSR2_RAT) | a somatostatin analog with pharmacologic properties mimicking those of the natural hormone somatostatin binds and activates the SSTRs resulting in inhibition of ACTH secretion, which leads to decreased cortisol secretion | Somatostatin Analog (Code: N0000175904) Somatostatin Receptor Agonists (Code: N0000000194) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) antineoplastic agent (Code: CHEBI:35610) | 2012-12-14 FDA | |
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| pixantrone | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) | an immunosuppressant; structure given in first source | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Topoisomerase II Inhibitors (Code: D059005) Topoisomerase Inhibitors (Code: D059003) | 2012-05-10 EMA | |
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| trinitrophenol | used as antiseptic, astringent & stimulant for epitheliazation; structure | Enzyme Inhibitors (Code: D004791) Indicators and Reagents (Code: D007202) Uncoupling Agents (Code: D014475) | None FDA | 1GVS 1VYP 1VYR 1VYS 4JEW 4JEX 5K1U 5K1W |
|
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| bazedoxifene | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) | an estrogen agonist/antagonist that acts as an agonist in some estrogen-sensitive tissues and an antagonist in others | Estrogen Agonist/Antagonist (Code: N0000175826) Bone Density Conservation Agents (Code: D050071) Estrogen Receptor Modulators (Code: D020847) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Selective Estrogen Receptor Modulators (Code: D020845) | 2013-10-03 FDA | 4XI3 |
|
|
| amifampridine | Voltage-gated potassium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43525|O43526|O95259|P16389|P17658|P22001|P22459|P22460|P48547|P51787|P56696|Q03721|Q09470|Q12809|Q14003|Q14721|Q16322|Q6PIU1|Q8NCM2|Q8TAE7|Q8TDN1|Q8TDN2|Q92953|Q96KK3|Q96L42|Q96PR1|Q96RP8|Q9BQ31|Q9H252|Q9H3M0|Q9NR82|Q9NS40|Q9NSA2|Q9NZV8|Q9UIX4|Q9UJ96|Q9UK17|Q9ULD8|Q9ULS6|Q9UQ05, gene: KCNA1|KCNA10|KCNA2|KCNA3|KCNA4|KCNA5|KCNA6|KCNA7|KCNB1|KCNB2|KCNC1|KCNC2|KCNC3|KCNC4|KCND1|KCND2|KCND3|KCNF1|KCNG1|KCNG2|KCNG3|KCNG4|KCNH1|KCNH2|KCNH3|KCNH4|KCNH5|KCNH6|KCNH7|KCNH8|KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5|KCNS1|KCNS2|KCNS3|KCNV1|KCNV2, swissprot: KCA10_HUMAN|KCNA1_HUMAN|KCNA2_HUMAN|KCNA3_HUMAN|KCNA4_HUMAN|KCNA5_HUMAN|KCNA6_HUMAN|KCNA7_HUMAN|KCNB1_HUMAN|KCNB2_HUMAN|KCNC1_HUMAN|KCNC2_HUMAN|KCNC3_HUMAN|KCNC4_HUMAN|KCND1_HUMAN|KCND2_HUMAN|KCND3_HUMAN|KCNF1_HUMAN|KCNG1_HUMAN|KCNG2_HUMAN|KCNG3_HUMAN|KCNG4_HUMAN|KCNH1_HUMAN|KCNH2_HUMAN|KCNH3_HUMAN|KCNH4_HUMAN|KCNH5_HUMAN|KCNH6_HUMAN|KCNH7_HUMAN|KCNH8_HUMAN|KCNQ1_HUMAN|KCNQ2_HUMAN|KCNQ3_HUMAN|KCNQ4_HUMAN|KCNQ5_HUMAN|KCNS1_HUMAN|KCNS2_HUMAN|KCNS3_HUMAN|KCNV1_HUMAN|KCNV2_HUMAN) | potassium channel blocker in membranes | 2009-12-23 EMA | 5NOW |
|
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| ambrisentan | Endothelin B receptor (Organism: Homo sapiens, class: GPCR, accessions: P24530, gene: EDNRB, swissprot: EDNRB_HUMAN) Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) | an endothelin receptor antagonist that is selective for the endothelin type-A (ETA) receptor | Endothelin Receptor Antagonist (Code: N0000175581) Endothelin Receptor Antagonists (Code: N0000175364) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) | 2007-06-15 FDA | |
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| angiotensinamide | None | |
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| pyronaridine | None | Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) | |
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| alogliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) | a selective, orally bioavailable inhibitor of the enzymatic activity of dipeptidyl peptidase-4 (DPP-4) that slows the inactivation of the incretin hormones, thereby increasing their bloodstream concentrations and reducing fasting and postprandial glucose concentrations in a glucose-dependent manner in patients with type 2 diabetes mellitus | Dipeptidyl-Peptidase IV Inhibitors (Code: D054873) Enzyme Inhibitors (Code: D004791) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Hypoglycemic Agents (Code: D007004) Incretins (Code: D054795) Dipeptidyl Peptidase 4 Inhibitors (Code: N0000175912) Dipeptidyl Peptidase 4 Inhibitor (Code: N0000175913) Protease Inhibitors (Code: D011480) hypoglycemic agent (Code: CHEBI:35526) | 2013-01-25 FDA | 3G0B |
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|
| bibrocathol | eye ointment; structure | |
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| bilastine | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) | None | None PMDA | |
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| bioallethrin | Synthetic analogs of the naturally occurring insecticides cinerin, jasmolin, and pyrethrin. (From Merck Index, 11th ed) | Insecticides (Code: D007306) Pesticides (Code: D010575) pyrethroid ester insecticide (Code: CHEBI:39116) | |
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| bisoxatin | None | |
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| anidulafungin | Beta-1,3-glucan synthase catalytic subunit 1 (Organism: Candida albicans, class: Enzyme, accessions: O13428, gene: GSC1, swissprot: O13428_CANAX) | a cyclic hexapeptide echinocandin; antifungal by noncompetitively inhibiting 1,3-beta-D-glucan synthase | Echinocandin Antifungal (Code: N0000175507) Lipopeptides (Code: N0000175508) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | 2007-09-20 EMA 2006-02-17 FDA | |
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| bosutinib | Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Protein kinase C theta type (Organism: Homo sapiens, class: Kinase, accessions: Q04759, gene: PRKCQ, swissprot: KPCT_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) Myosin-IIIb (Organism: Homo sapiens, class: Kinase, accessions: Q8WXR4, gene: MYO3B, swissprot: MYO3B_HUMAN) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) Serine/threonine-protein kinase PAK 3 (Organism: Homo sapiens, class: Kinase, accessions: O75914, gene: PAK3, swissprot: PAK3_HUMAN) Cyclin-dependent kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q96Q40, gene: CDK15, swissprot: CDK15_HUMAN) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Serine/threonine-protein kinase NIM1 (Organism: Homo sapiens, class: Kinase, accessions: Q8IY84, gene: NIM1K, swissprot: NIM1_HUMAN) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) Casein kinase I isoform delta (Organism: Homo sapiens, class: Kinase, accessions: P48730, gene: CSNK1D, swissprot: KC1D_HUMAN) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) Serine/threonine-protein kinase PLK1 (Organism: Homo sapiens, class: Kinase, accessions: P53350, gene: PLK1, swissprot: PLK1_HUMAN) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) Serine/threonine-protein kinase Nek11 (Organism: Homo sapiens, class: Kinase, accessions: Q8NG66, gene: NEK11, swissprot: NEK11_HUMAN) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) STE20/SPS1-related proline-alanine-rich protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UEW8, gene: STK39, swissprot: STK39_HUMAN) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) Dual specificity protein kinase CLK3 (Organism: Homo sapiens, class: Kinase, accessions: P49761, gene: CLK3, swissprot: CLK3_HUMAN) Tyrosine-protein kinase Blk (Organism: Mus musculus, class: Kinase, accessions: P16277, gene: Blk, swissprot: BLK_MOUSE) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) Serine/threonine-protein kinase tousled-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q86UE8, gene: TLK2, swissprot: TLK2_HUMAN) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: Q13555, gene: CAMK2G, swissprot: KCC2G_HUMAN) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) Citron Rho-interacting kinase (Organism: Homo sapiens, class: Kinase, accessions: O14578, gene: CIT, swissprot: CTRO_HUMAN) Ribosomal protein S6 kinase alpha-3 (Organism: Homo sapiens, class: Kinase, accessions: P51812, gene: RPS6KA3, swissprot: KS6A3_HUMAN) Myosin-IIIa (Organism: Homo sapiens, class: Kinase, accessions: Q8NEV4, gene: MYO3A, swissprot: MYO3A_HUMAN) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) Serine/threonine-protein kinase 25 (Organism: Homo sapiens, class: Kinase, accessions: O00506, gene: STK25, swissprot: STK25_HUMAN) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) Casein kinase I isoform alpha-like (Organism: Homo sapiens, class: Kinase, accessions: Q8N752, gene: CSNK1A1L, swissprot: KC1AL_HUMAN) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) Megakaryocyte-associated tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P42679, gene: MATK, swissprot: MATK_HUMAN) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Organism: Homo sapiens, class: Kinase, accessions: Q99640, gene: PKMYT1, swissprot: PMYT1_HUMAN) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) Macrophage-stimulating protein receptor (Organism: Homo sapiens, class: Kinase, accessions: Q04912, gene: MST1R, swissprot: RON_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Serine/threonine-protein kinase PAK 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13153, gene: PAK1, swissprot: PAK1_HUMAN) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) Serine/threonine-protein kinase Nek2 (Organism: Homo sapiens, class: Kinase, accessions: P51955, gene: NEK2, swissprot: NEK2_HUMAN) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Organism: Homo sapiens, class: Kinase, accessions: P06748|Q9UM73, gene: ALK|NPM1, swissprot: ALK_HUMAN|NPM_HUMAN) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) Eukaryotic translation initiation factor 2-alpha kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BQI3, gene: EIF2AK1, swissprot: E2AK1_HUMAN) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) Serine/threonine-protein kinase PLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NYY3, gene: PLK2, swissprot: PLK2_HUMAN) Bone morphogenetic protein receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: Q13873, gene: BMPR2, swissprot: BMPR2_HUMAN) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) Dual specificity mitogen-activated protein kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O14733, gene: MAP2K7, swissprot: MP2K7_HUMAN) Peripheral plasma membrane protein CASK (Organism: Homo sapiens, class: Kinase, accessions: O14936, gene: CASK, swissprot: CSKP_HUMAN) Dual serine/threonine and tyrosine protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q6XUX3, gene: DSTYK, swissprot: DUSTY_HUMAN) Serine/threonine-protein kinase PknB (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WI81, gene: pknB, swissprot: PKNB_MYCTU) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) Tyrosine-protein kinase Srms (Organism: Homo sapiens, class: Kinase, accessions: Q9H3Y6, gene: SRMS, swissprot: SRMS_HUMAN) Casein kinase I isoform alpha (Organism: Homo sapiens, class: Kinase, accessions: P48729, gene: CSNK1A1, swissprot: KC1A_HUMAN) Mitogen-activated protein kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13233, gene: MAP3K1, swissprot: M3K1_HUMAN) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) Serine/threonine-protein kinase 32A (Organism: Homo sapiens, class: Kinase, accessions: Q8WU08, gene: STK32A, swissprot: ST32A_HUMAN) Serine/threonine-protein kinase SIK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2K2, gene: SIK3, swissprot: SIK3_HUMAN) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Serine/threonine-protein kinase 24 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6E0, gene: STK24, swissprot: STK24_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Tyrosine-protein kinase ABL (Organism: Homo sapiens, class: Kinase, accessions: P00519|P42684, gene: ABL1|ABL2, swissprot: ABL1_HUMAN|ABL2_HUMAN) Wee1-like protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P0C1S8, gene: WEE2, swissprot: WEE2_HUMAN) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) Hormonally up-regulated neu tumor-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: P57058, gene: HUNK, swissprot: HUNK_HUMAN) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) Protein kinase C delta type (Organism: Homo sapiens, class: Kinase, accessions: Q05655, gene: PRKCD, swissprot: KPCD_HUMAN) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) Cyclin-dependent kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: O94921, gene: CDK14, swissprot: CDK14_HUMAN) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) Serine/threonine-protein kinase PAK 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13177, gene: PAK2, swissprot: PAK2_HUMAN) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) Ephrin type-B receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29323, gene: EPHB2, swissprot: EPHB2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) Serine/threonine-protein kinase tousled-like 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UKI8, gene: TLK1, swissprot: TLK1_HUMAN) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) Serine/threonine-protein kinase VRK2 (Organism: Homo sapiens, class: Kinase, accessions: Q86Y07, gene: VRK2, swissprot: VRK2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: P52564, gene: MAP2K6, swissprot: MP2K6_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Ephrin type-B receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P54753, gene: EPHB3, swissprot: EPHB3_HUMAN) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) Tyrosine-protein kinase Tec (Organism: Homo sapiens, class: Kinase, accessions: P42680, gene: TEC, swissprot: TEC_HUMAN) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) Bcr/Abl fusion protein (Organism: Homo sapiens, class: Kinase, accessions: P00519|P11274, gene: ABL1|BCR, swissprot: ABL1_HUMAN|BCR_HUMAN) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) Serine/threonine-protein kinase NLK (Organism: Homo sapiens, class: Kinase, accessions: Q9UBE8, gene: NLK, swissprot: NLK_HUMAN) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) Mitogen-activated protein kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q13164, gene: MAPK7, swissprot: MK07_HUMAN) | a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) P-Glycoprotein Inhibitors (Code: N0000185503) antineoplastic agent (Code: CHEBI:35610) | 2012-09-04 FDA | 5AJQ 5I9X 3SOA 3UE4 4MXO 4MXX 4MXY 4MXZ 4OTW 4QMN 5VC3 5VCY |
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| chenodiol | fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) | A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones. | Cathartics (Code: D002400) Gastrointestinal Agents (Code: D005765) | 1983-07-28 FDA | 3O02 4QE6 |
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| vernakalant | Potassium voltage-gated channel subfamily A member 5 (Organism: Homo sapiens, class: Ion channel, accessions: P22460, gene: KCNA5, swissprot: KCNA5_HUMAN) | Vernakalant is an antiarrhythmic medicine that acts preferentially in the atria to prolong atrial refractoriness and to rate-dependently slow impulse conduction. These anti-fibrillatory actions on refractoriness and conduction are thought to suppress re-entry, and are potentiated in the atria during atrial fibrillation. The relative selectivity of vernakalant on atrial versus ventricular refractoriness is postulated to result from the block of currents that are expressed in the atria, but not in the ventricles, as well as the unique electrophysiologic condition of the fibrillating atria. However, blockade of cationic currents, including hERG channels and cardiac voltage-dependent sodium channels, which are present in the ventricles has been documented. | 2010-09-01 EMA | |
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| voclosporin | semi-synthetic cyclosporine A analog & calcineurin inhibitor | |
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| xantinol | A vasodilator used in peripheral vascular disorders and insufficiency. It may cause gastric discomfort and hypotension. | Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) | |
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| triaziquone | Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) antineoplastic agent (Code: CHEBI:35610) | |
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| amiloxate | None | None FDA | |
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| lorcaserin | 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) | a serotonin 2C receptor agonist for oral administration used for chronic weight management | Serotonin-2c Receptor Agonist (Code: N0000185010) Serotonin 2c Receptor Agonists (Code: N0000185009) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) appetite depressant (Code: CHEBI:50507) | 2012-06-27 FDA | |
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| demecolcine | An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic. | Antimitotic Agents (Code: D050256) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Mitosis Modulators (Code: D050258) Tubulin Modulators (Code: D050257) antineoplastic agent (Code: CHEBI:35610) | |
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| dequalinium | Small conductance calcium-activated potassium channel protein 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q92952, gene: KCNN1, swissprot: KCNN1_HUMAN) Small conductance calcium-activated potassium channel protein 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P70605, gene: Kcnn3, swissprot: KCNN3_RAT) Small conductance calcium-activated potassium channel protein 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UGI6, gene: KCNN3, swissprot: KCNN3_HUMAN) Protein kinase C alpha type (Organism: Homo sapiens, class: Kinase, accessions: P17252, gene: PRKCA, swissprot: KPCA_HUMAN) cGMP-gated cation channel alpha-1 (Organism: Homo sapiens, class: Unclassified, accessions: P29973, gene: CNGA1, swissprot: CNGA1_HUMAN) Cyclic nucleotide-gated olfactory channel (Organism: Homo sapiens, class: Unclassified, accessions: Q16280, gene: CNGA2, swissprot: CNGA2_HUMAN) | A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration. | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) antineoplastic agent (Code: CHEBI:35610) antiseptic drug (Code: CHEBI:48218) | 1JT6 1OYD 3ARP 3ART 3BR1 3BR2 3BT9 3BTJ 3VW0 |
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| desaspidin | None | |
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| decamethrin | A synthetic pyrethroid insecticide with contact and residual activity, also used as an acaricide. | Insecticides (Code: D007306) Pesticides (Code: D010575) pyrethroid ester insecticide (Code: CHEBI:39116) agrochemical (Code: CHEBI:33286) | |
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| degarelix | Gonadotropin-releasing hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: P30968, gene: GNRHR, swissprot: GNRHR_HUMAN) | FE-200486 is the acetate salt | 2008-12-24 FDA | |
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| desvenlafaxine | Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) | The exact mechanism of the antidepressant action of desvenlafaxine is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system, through inhibition of their reuptake. Non-clinical studies have shown that desvenlafaxine is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). | Norepinephrine Uptake Inhibitors (Code: N0000000102) Serotonin and Norepinephrine Reuptake Inhibitor (Code: N0000175749) Serotonin Uptake Inhibitors (Code: N0000000109) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin and Noradrenaline Reuptake Inhibitors (Code: D000068760) antidepressant (Code: CHEBI:35469) | 2008-02-29 FDA | 4MM7 4MMC |
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| dapoxetine | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) | selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation | |
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| mirabegron | Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) | a beta-3 adrenergic agonist, relaxes the detrusor smooth muscle during the storage phase of the urinary bladder fill-void cycle by activation of beta-3 AR which increases bladder capacity | beta3-Adrenergic Agonist (Code: N0000185008) Adrenergic beta3-Agonists (Code: N0000185007) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-3 Receptor Agonists (Code: D058667) Adrenergic beta-Agonists (Code: D000318) Neurotransmitter Agents (Code: D018377) Urological Agents (Code: D064804) beta-adrenergic agonist (Code: CHEBI:35522) | 2012-06-28 FDA | |
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| levofolinic acid | A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN. | Antidotes (Code: D000931) Protective Agents (Code: D020011) antineoplastic agent (Code: CHEBI:35610) | 2008-03-07 FDA | 1DFO 1EQB 1JOL 1JOM 1PJ7 1WOP 2VMY 3SD3 3SUH 3UWL 4GTA 4LVV |
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| clefamide | None | |
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| clevudine | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | |
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| clopenthixol | A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) first generation antipsychotic (Code: CHEBI:65190) H1-receptor antagonist (Code: CHEBI:37955) serotonergic antagonist (Code: CHEBI:48279) alpha-adrenergic antagonist (Code: CHEBI:37890) dopaminergic antagonist (Code: CHEBI:48561) | |
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| tegafur | Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms. | Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | 2011-03-14 EMA | |
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| eltrombopag | Thrombopoietin receptor (Organism: Homo sapiens, class: Membrane receptor, accessions: P40238, gene: MPL, swissprot: TPOR_HUMAN) | an oral, nonpeptide thrombopoietin receptor agonist | Increased Megakaryocyte Maturation (Code: N0000175969) Increased Platelet Production (Code: N0000175970) Thrombopoiesis Stimulating Agent (Code: N0000178368) Thrombopoietin Receptor Agonists (Code: N0000175968) Thrombopoietin Receptor Interactions (Code: N0000175967) Thrombopoietin Receptor Agonist (Code: N0000175973) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) UGT1A1 Inhibitors (Code: N0000191272) UGT1A3 Inhibitors (Code: N0000191275) UGT1A4 Inhibitors (Code: N0000191276) UGT1A6 Inhibitors (Code: N0000191277) UGT1A9 Inhibitors (Code: N0000191278) UGT2B7 Inhibitors (Code: N0000191273) UGT2B15 Inhibitors (Code: N0000191274) | 2010-03-11 EMA 2008-11-20 FDA | |
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| carisbamate | experimental anticonvulsant and neuromodulator | |
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| cyfluthrin | effective against mosquitoes | Insecticides (Code: D007306) Pesticides (Code: D010575) pyrethroid ester insecticide (Code: CHEBI:39116) agrochemical (Code: CHEBI:33286) | |
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| candicidin | Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component. | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) | None FDA | |
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| casopitant | Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) | None | Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurokinin-1 Receptor Antagonists (Code: D064729) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) | |
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| ceftobiprole medocaril | MecA (Organism: Staphylococcus aureus, class: Unclassified, accessions: Q7DHH4, gene: mecA, swissprot: Q7DHH4_STAAU) | a ceftobiprole prodrug | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) prodrug (Code: CHEBI:50266) | |
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| cymarin | None | |
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| cypermethrin | None | Insecticides (Code: D007306) Pesticides (Code: D010575) molluscicide (Code: CHEBI:33904) pyrethroid ester insecticide (Code: CHEBI:39116) agrochemical (Code: CHEBI:33286) | |
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| plerixafor | Stromal cell-derived factor 1 (Organism: Homo sapiens, class: Cytokine, accessions: P48061, gene: CXCL12, swissprot: SDF1_HUMAN) C-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P51679, gene: CCR4, swissprot: CCR4_HUMAN) Atypical chemokine receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P25106, gene: ACKR3, swissprot: ACKR3_HUMAN) C-X-C chemokine receptor type 4 (Organism: Homo sapiens, class: GPCR, accessions: P61073, gene: CXCR4, swissprot: CXCR4_HUMAN) C-X-C chemokine receptor type 4 (Organism: Rattus norvegicus, class: GPCR, accessions: O08565, gene: Cxcr4, swissprot: CXCR4_RAT) C-C chemokine receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: P41597, gene: CCR2, swissprot: CCR2_HUMAN) | Plerixafor is an inhibitor of the CXCR4 chemokine receptor and blocks binding of its cognate ligand, stromal cell-derived factor-1alpha (SDF-1alpha). SDF-1alpha and CXCR4 are recognized to play a role in the trafficking and homing of human hematopoietic stem cells (HSCs) to the marrow compartment. Once in the marrow, stem cell CXCR4 can act to help anchor these cells to the marrow matrix, either directly via SDF-1alpha or through the induction of other adhesion molecules. Treatment with plerixafor resulted in leukocytosis and elevations in circulating hematopoietic progenitor cells in mice, dogs and humans. CD34+ cells mobilized by plerixafor were capable of engraftment with long-term repopulating capacity up to one year in canine transplantation models. | Hematopoietic Stem Cell Mobilizer (Code: N0000178326) Increased Hematopoietic Stem Cell Mobilization (Code: N0000178324) | 2008-12-15 FDA | |
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| diamorphine | A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) | Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) opioid analgesic (Code: CHEBI:35482) mu-opioid receptor agonist (Code: CHEBI:55322) prodrug (Code: CHEBI:50266) | |
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| dibromotyrosine | None | 1EBA 4TPG 4TPH |
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| dibutylphthalate | A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure. | Plasticizers (Code: D010968) plasticiser (Code: CHEBI:79056) | 4G5I |
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| dibutylsuccinate | None | |
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| diethyl ether | None | refrigerant (Code: CHEBI:78433) inhalation anaesthetic (Code: CHEBI:38870) | |
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| etybenzatropine | minor descriptor (65-66); major descriptor (66-79); on-line search ETHYBENZTROPINE (65-79); Index Medicus search ETHYBENZTROPINE (66-79); RN given refers to (endo)-isomer of parent cpd | |
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| diethyltoluamide | A compound used as a topical insect repellent that may cause irritation to eyes and mucous membranes, but not to the skin. | Insect Repellents (Code: D007302) Pesticides (Code: D010575) Protective Agents (Code: D020011) insect repellent (Code: CHEBI:71692) | None FDA | 3N7H |
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| difetarsone | None | |
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| dihydroergocryptine | 5-hydroxytryptamine receptor 7 (Organism: Mus musculus, class: GPCR, accessions: P32304, gene: Htr7, swissprot: 5HT7R_MOUSE) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) | A 9,10alpha-dihydro derivative of ERGOTAMINE that contains an isopropyl sidechain at the 2' position and an alpha-isobutyl sidechain at 5'alpha position of the molecule. | Cardiovascular Agents (Code: D002317) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) | None FDA | |
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| diiodohydroxypropane | None | |
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| etilevodopa | is the ethyl ester of levodopa; an antiparkinson drug | |
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| calcitonin human | Calcitonin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30988, gene: CALCR, swissprot: CALCR_HUMAN) Amylin receptor AMY1 (Organism: Homo sapiens, class: GPCR, accessions: O60894|P30988, gene: CALCR|RAMP1, swissprot: CALCR_HUMAN|RAMP1_HUMAN) Amylin receptor AMY2 (Organism: Homo sapiens, class: GPCR, accessions: O60895|P30988, gene: CALCR|RAMP2, swissprot: CALCR_HUMAN|RAMP2_HUMAN) Amylin receptor AMY3 (Organism: Homo sapiens, class: GPCR, accessions: O60896|P30988, gene: CALCR|RAMP3, swissprot: CALCR_HUMAN|RAMP3_HUMAN) | None | 1986-10-31 FDA | |
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| diphenadione | major descriptor (66-86); on-line search PHENINDIONE (66-74); PHENINDIONE/AA (75-86); INDEX MEDICUS search DIPHENADIONE (66-86); RN given refers to parent cpd | |
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| prednisolone sodium phosphate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1973-12-19 FDA | |
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| clobetasol propionate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) Annexin A1 (Organism: Homo sapiens, class: Cytosolic other, accessions: P04083, gene: ANXA1, swissprot: ANXA1_HUMAN) Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) | A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) | 1985-12-27 FDA | |
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| testosterone cypionate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | cypionate ester of the androgenic hormone testosterone | 1978-06-23 FDA | |
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| eosin | RmtA (Organism: Emericella nidulans, class: Enzyme, accessions: Q5VLE3, gene: rmtA, swissprot: Q5VLE3_EMEND) Protein arginine N-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q99873, gene: PRMT1, swissprot: ANM1_HUMAN) | None | fluorochrome (Code: CHEBI:51217) histological dye (Code: CHEBI:77178) | |
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| fludeoxyglucose (18F) | None | Radioactive Diagnostic Agent (Code: N0000177914) Radiopharmaceutical Activity (Code: N0000000205) | 1994-08-19 FDA | |
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| hydrocortisone succinate | Glucocorticoid receptor (Organism: Mus musculus, class: Transcription factor, accessions: P06537, gene: Nr3c1, swissprot: GCR_MOUSE) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1955-04-27 FDA | |
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| sulfisoxazole acetyl | Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) | None | 1953-12-04 FDA | |
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| efaproxiral | None | Antisickling Agents (Code: D000986) Hematologic Agents (Code: D006401) Radiation-Sensitizing Agents (Code: D011838) | 1G9V 5E29 |
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| epanolol | None | Adrenergic Agents (Code: D018663) Adrenergic Antagonists (Code: D018674) Adrenergic beta-Antagonists (Code: D000319) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) | |
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| esketamine | None | analgesic (Code: CHEBI:35480) intravenous anaesthetic (Code: CHEBI:38877) | |
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| fosaprepitant | Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) | a pro-drug form of aprepitant | Neurokinin 1 Antagonists (Code: N0000010262) Substance P/Neurokinin-1 Receptor Antagonist (Code: N0000175786) Antiemetics (Code: D000932) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Neurokinin-1 Receptor Antagonists (Code: D064729) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) antiemetic (Code: CHEBI:50919) prodrug (Code: CHEBI:50266) | 2003-03-27 FDA | |
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| N-Acetyltyrosine | None | biomarker (Code: CHEBI:59163) | None FDA | 3NFZ |
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| corbadrine | Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) | None | 1960-01-06 FDA | |
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| carfilzomib | Proteasome subunit beta type-5 (Organism: Homo sapiens, class: Enzyme, accessions: P28074, gene: PSMB5, swissprot: PSB5_HUMAN) Cathepsin B (Organism: Homo sapiens, class: Enzyme, accessions: P07858, gene: CTSB, swissprot: CATB_HUMAN) Proteasome subunit beta type-8 (Organism: Homo sapiens, class: Enzyme, accessions: P28062, gene: PSMB8, swissprot: PSB8_HUMAN) | epoxomicin derivative proteasome inhibitor with antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells | Proteasome Inhibitors (Code: N0000175075) antineoplastic agent (Code: CHEBI:35610) proteasome inhibitor (Code: CHEBI:52726) | 2012-07-20 FDA | |
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| aclidinium bromide | Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) | a long-acting, inhaled antimuscarinic; in phase I trial 8/2008 | Anticholinergic (Code: N0000175574) Cholinergic Antagonists (Code: N0000175370) muscarinic antagonist (Code: CHEBI:48876) bronchodilator agent (Code: CHEBI:35523) | 2012-07-20 EMA 2012-07-23 FDA | |
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| diflorasone diacetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | topical corticosteroid has anti-inflammatory, anti-pruritic, and vasoconstrictive actions | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1977-09-14 FDA | |
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| taurine | A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids. | None FDA | |
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| alclometasone dipropionate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) | 1982-12-14 FDA | |
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| haloperidol decanoate | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(1A) dopamine receptor (Organism: Sus scrofa, class: GPCR, accessions: P50130, gene: DRD1, swissprot: DRD1_PIG) | None | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) | 1986-01-14 FDA | |
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| estradiol acetate | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) | None | 2003-03-20 FDA | |
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| paliperidone palmitate | D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | A benzisoxazole derivative and active metabolite of RISPERIDONE that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST and SEROTONIN 5-HT2 RECEPTOR ANTAGONIST. It is an ANTIPSYCHOTIC AGENT used in the treatment of SCHIZOPHRENIA. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Dopamine Agents (Code: D015259) Dopamine Antagonists (Code: D018492) Dopamine D2 Receptor Antagonists (Code: D065127) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin 5-HT2 Receptor Antagonists (Code: D058830) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Tranquilizing Agents (Code: D014149) alpha-adrenergic antagonist (Code: CHEBI:37890) dopaminergic antagonist (Code: CHEBI:48561) H1-receptor antagonist (Code: CHEBI:37955) neuroprotective agent (Code: CHEBI:63726) psychotropic drug (Code: CHEBI:35471) second generation antipsychotic (Code: CHEBI:65191) serotonergic antagonist (Code: CHEBI:48279) | 2009-07-31 FDA | |
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| armodafinil | Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) | the R-enantiomer of modafinil | Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Wakefulness-Promoting Agents (Code: D064690) central nervous system stimulant (Code: CHEBI:35337) eugeroic (Code: CHEBI:77567) | 2007-06-05 FDA | |
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| hydrocortisone valerate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | used in treatment of atopic dermatitis; RN given refers to 11beta-isomer | 1978-03-17 FDA | |
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| choline fenofibrate | Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Fatty acid-binding protein, liver (Organism: Rattus norvegicus, class: Unclassified, accessions: P02692, gene: Fabp1, swissprot: FABPL_RAT) Fatty acid-binding protein, intestinal (Organism: Homo sapiens, class: Cytosolic other, accessions: P12104, gene: FABP2, swissprot: FABPI_HUMAN) | metabolite of lipantyl; structure; salt of cholesterylamine & 2-(4-(p-chlorobenzoyl)phenoxy)2-methylpropionic acid | Peroxisome Proliferator Receptor alpha Agonist (Code: N0000175596) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) | 2008-12-15 FDA | |
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| halcinonide | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) | A glucocorticoid used topically in the treatment of DERMATITIS; ECZEMA; or PSORIASIS. It may cause skin irritation. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Inflammatory Agents (Code: D000893) | 1974-11-27 FDA | |
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| linolenic acid | Fatty acid-binding protein, heart (Organism: Homo sapiens, class: Cytosolic other, accessions: P05413, gene: FABP3, swissprot: FABPH_HUMAN) Aromatase (Organism: Homo sapiens, class: Enzyme, accessions: P11511, gene: CYP19A1, swissprot: CP19A_HUMAN) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) Tissue factor (Organism: Homo sapiens, class: Membrane receptor, accessions: P13726, gene: F3, swissprot: TF_HUMAN) | A fatty acid that is found in plants and involved in the formation of prostaglandins. | nutraceutical (Code: CHEBI:50733) | None FDA | 1FK6 2BYO 4E1G |
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| racepinefrine | Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) | A racemic mixture of d-epinephrine and l-epinephrine. | Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) | None FDA | 2HKK 3PAH 4A7U 4LDO |
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| tetracosactide | Adrenocorticotropic hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q01718, gene: MC2R, swissprot: ACTHR_HUMAN) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) | A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX. | Adrenocorticotropic Hormone (Code: N0000006478) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) diagnostic agent (Code: CHEBI:33295) | 1970-04-22 FDA | |
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| teriparatide | Parathyroid hormone/parathyroid hormone-related peptide receptor (Organism: Homo sapiens, class: GPCR, accessions: Q03431, gene: PTH1R, swissprot: PTH1R_HUMAN) Parathyroid hormone 2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P49190, gene: PTH2R, swissprot: PTH2R_HUMAN) Parathyroid hormone 2 receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P70555, gene: Pth2r, swissprot: PTH2R_RAT) | A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) | Parathyroid Hormone (Code: N0000011221) Parathyroid Hormone Analog (Code: N0000180852) Bone Density Conservation Agents (Code: D050071) | 2003-06-10 EMA 2002-11-26 FDA | |
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| quinine | Hemoglobin subunit alpha (Organism: Homo sapiens, class: Secreted, accessions: P69905, gene: HBA1, swissprot: HBA_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) Equilibrative nucleoside transporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q7RTT9, gene: SLC29A4, swissprot: S29A4_HUMAN) Potassium voltage-gated channel subfamily B member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q92953, gene: KCNB2, swissprot: KCNB2_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Homo sapiens, class: Ion channel, accessions: P35498|Q99250|Q9NY46, gene: SCN1A|SCN2A|SCN3A, swissprot: SCN1A_HUMAN|SCN2A_HUMAN|SCN3A_HUMAN) | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. | Antimalarial (Code: N0000175482) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-narcotic analgesic (Code: CHEBI:35481) antimalarial (Code: CHEBI:38068) muscle relaxant (Code: CHEBI:51371) | 2005-08-12 FDA | 4UIL 4UIN 4WNV |
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| bismuth subgallate | None | Anti-Infective Agents (Code: D000890) Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) astringent (Code: CHEBI:74783) | |
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| fazadinium | FAZADINIUM BROMIDE was heading 1991-94; was FAZADINIUM see under PYRIDINIUM COMPOUNDS 1979-90; was AH 8165 see under PYRIDINIUM COMPOUNDS 1975-78; AH 8165 was see FAZADINIUM BROMIDE 1979-94; use PYRIDINIUM COMPOUNDS to search FAZADINIUM BROMIDE 1991-94, FAZADINIUM 1979-90 & AH 8165 1975-78; a rapid-acting, short-lasting, competitive nondepolarizing neuromuscular blocking agent; its action is rapidly and completely reversed by neostigmine | |
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| fluclorolone | None | |
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| fenbendazole | Mitogen-activated protein kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: Q16539, gene: MAPK14, swissprot: MK14_HUMAN) Beta-lactamase 1 (Organism: Bacillus cereus, class: Enzyme, accessions: P10424, gene: penPC, swissprot: BLA1_BACCE) | Antinematodal benzimidazole used in veterinary medicine. | Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) antinematodal drug (Code: CHEBI:35444) | |
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| fluprednidene | None | |
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| flumedroxone | used for treatment of migraine & premenstrual tension; RN given refers to parent cpd; structure | |
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| flumetasone | An anti-inflammatory glucocorticoid used in veterinary practice. | Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) anti-inflammatory drug (Code: CHEBI:35472) | |
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| fluorodopa (18F) | None | |
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| fluoroethylcholine (18F) | None | |
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| gepirone | 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) | None | Anti-Anxiety Agents (Code: D014151) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Tranquilizing Agents (Code: D014149) | |
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| fluticasone furoate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) Glucocorticoid receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P06536, gene: Nr3c1, swissprot: GCR_RAT) | Fluticasone furoate is a synthetic trifluorinated corticosteroid with anti'inflammatory activity. Fluticasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor. The precise mechanism of corticosteroid action on asthma is not known. Inflammation is an important component in the pathogenesis of asthma. Corticosteroids have been shown to have a wide range of actions on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. These anti-inflammatory actions of corticosteroids contribute to their efficacy in asthma. | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Anti-Allergic Agents (Code: D018926) Anti-Asthmatic Agents (Code: D018927) Anti-Inflammatory Agents (Code: D000893) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Dermatologic Agents (Code: D003879) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) prodrug (Code: CHEBI:50266) anti-allergic agent (Code: CHEBI:50857) anti-asthmatic drug (Code: CHEBI:49167) | 2007-04-27 FDA | 3CLD |
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| gestonorone | None | |
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| guanoclor | None | |
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| nomegestrol | 19-nor-progesterone derivative; structure given in UD | |
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| hydrocortisone probutate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1997-02-28 FDA | |
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| hydroquinine | None | |
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| hydroxyethylpromethazine | None | |
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| iclaprim | Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) Dihydrofolate reductase (Organism: Escherichia coli, class: Unclassified, accessions: B0BL08, gene: dfrA17, swissprot: B0BL08_ECOLX) Dihydrofolate reductase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P0A017, gene: folA, swissprot: DYR_STAAU) | has antiviral activity | Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) | 3FRA 3FRF 3FY8 3FY9 3FYV 3FYW |
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| idanpramine | None | |
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| indigo carmine | Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk. | Coloring Agents (Code: D004396) food colouring (Code: CHEBI:77182) histological dye (Code: CHEBI:77178) two-colour indicator (Code: CHEBI:50412) | None FDA | |
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| iobenguane (131I) | A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase. | |
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| iodocholesterol (131I) | None | |
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| ioglicic acid | None | |
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| testosterone enantate | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | None | Androgens (Code: D000728) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1953-12-24 FDA | |
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| iopydol | None | |
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| ioxitalamic acid | None | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | |
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| itramin tosilate | None | |
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| levomethadone | Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) | None | |
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| levoverbenone | None | expectorant (Code: CHEBI:77035) | |
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| linopirdine | Potassium voltage-gated channel subfamily KQT member 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NR82, gene: KCNQ5, swissprot: KCNQ5_HUMAN) Potassium voltage-gated channel subfamily KQT member 4 (Organism: Homo sapiens, class: Ion channel, accessions: P56696, gene: KCNQ4, swissprot: KCNQ4_HUMAN) Potassium voltage-gated channel subfamily KQT member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O43526, gene: KCNQ2, swissprot: KCNQ2_HUMAN) Potassium voltage-gated channel subfamily KQT member 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: O88944, gene: Kcnq3, swissprot: KCNQ3_RAT) Potassium voltage-gated channel subfamily KQT member 1 (Organism: Mus musculus, class: Unclassified, accessions: P97414, gene: Kcnq1, swissprot: KCNQ1_MOUSE) | acetylcholine releasing drug | Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neuroprotective Agents (Code: D018696) Potassium Channel Blockers (Code: D026902) Protective Agents (Code: D020011) | |
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| linsidomine | None | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Nitric Oxide Donors (Code: D020030) Platelet Aggregation Inhibitors (Code: D010975) Vasodilator Agents (Code: D014665) | |
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| diazolidinylurea | None | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) | |
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| mannosulfan | minor descriptor (75-84); on-line & Index Medicus search METHANESULFONATES (75-84) | |
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| diosmetin | Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) Cytochrome P450 1B1 (Organism: Homo sapiens, class: Enzyme, accessions: Q16678, gene: CYP1B1, swissprot: CP1B1_HUMAN) | a 5,7-dihydroxyflavone | antineoplastic agent (Code: CHEBI:35610) | None FDA | |
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| diethylamino hydroxybenzoyl hexyl benzoate | a UV filtering agent | None FDA | |
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| morniflumate | None | |
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| xylitol | A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. | Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) sweetening agent (Code: CHEBI:50505) | None FDA | 1FX5 1LTE 1NJR 1S5N 1W3Y 1XIG 1XIM 1XIN 1XLC 1XLD 1XLG 1XLJ 1XLM 2B4C 2VFS 2XIM 2XIS 3GNX 3IAG 3LBW 3M1C 3MJ4 3OXH 4DUO 4F2D 4GNA 4Q0S 4RS3 4XWH 5IAI 5NH6 5XIA 5Y4J |
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| tonzonium | Insulin-degrading enzyme (Organism: Homo sapiens, class: Enzyme, accessions: P14735, gene: IDE, swissprot: IDE_HUMAN) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63470, gene: Dyrk1a, swissprot: DYR1A_RAT) | a surfactant with antifungal activity; also inhibits osteoclast formation | 1962-05-17 FDA | |
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| clocortolone pivalate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | topical, anti-inflammatory glucocorticoid; structure | Corticosteroid (Code: N0000175576) Corticosteroid Hormone Receptor Agonists (Code: N0000175450) Adrenal Cortex Hormones (Code: D000305) Anti-Inflammatory Agents (Code: D000893) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1977-08-22 FDA | |
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| ubidecarenone | prevents hemorrhagic state | None FDA | |
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| trypan blue | Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) Tyrosine-protein phosphatase 1 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P25044, gene: PTP1, swissprot: PTP1_YEAST) | A diazo-naphthalene sulfonate that is widely used as a stain. | Diagnostic Dye (Code: N0000175536) Dyes (Code: N0000175533) Coloring Agents (Code: D004396) dye (Code: CHEBI:37958) | 2004-12-16 FDA | |
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| sucrose | A nonreducing disaccharide composed of GLUCOSE and FRUCTOSE linked via their anomeric carbons. It is obtained commercially from SUGARCANE, sugar beet (BETA VULGARIS), and other plants and used extensively as a food and a sweetener. | Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) sweetening agent (Code: CHEBI:50505) | None FDA | |
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| stearic acid | Fatty acid-binding protein, adipocyte (Organism: Homo sapiens, class: Cytosolic other, accessions: P15090, gene: FABP4, swissprot: FABP4_HUMAN) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) | None | None FDA | |
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| protocatechualdehyde | found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure | Anticoagulants (Code: D000925) Hematologic Agents (Code: D006401) | None FDA | |
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| 1-Octacosanol | None | None FDA | 5TVI |
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| polydatin | from Polygonum cuspidatum | anti-arrhythmia drug (Code: CHEBI:38070) hepatoprotective agent (Code: CHEBI:62868) nephroprotective agent (Code: CHEBI:76595) | None FDA | |
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| N-Acetylglucosamine | The N-acetyl derivative of glucosamine. | None FDA | |
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| methylnaltrexone | Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) | a selective antagonist of opioid binding at the mu-opioid receptor with restricted ability to cross the blood-brain barrier, function as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids without impacting opioid-mediated analgesic effects on the central nervous system | Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) Quaternary Ammonium Compounds (Code: N0000166489) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) | 2008-07-02 EMA 2008-04-24 FDA | |
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| levomenol | drug combination containing chamomile and bisabolol; used to treat dermatitis | None FDA | |
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| diacetyl benzoyl lathyrol | None | None FDA | |
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| levomefolic acid | Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) | an ingredient in Contraceptives, Oral, Combined | 2010-09-24 FDA | 1B02 1Q8J 1TLS 1TSN 1U1J 1XPG 1XR2 1ZP4 2E7F 2IDK 2OGY 2YCJ 3A8I 3FSU 3IJD 3THR 4DJE 4DJF 4FOG 4L64 4L65 4O1E 5FCT 5VOO 5VOP |
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| linaclotide | Heat-stable enterotoxin receptor (Organism: Homo sapiens, class: Enzyme, accessions: P25092, gene: GUCY2C, swissprot: GUC2C_HUMAN) Heat-stable enterotoxin receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P23897, gene: Gucy2c, swissprot: GUC2C_RAT) | Linaclotide is a guanylate cyclase-C (GC-C) agonist. Both linaclotide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP). Elevation in intracellular cGMP stimulates secretion of chloride and bicarbonate into the intestinal lumen, mainly through activation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, resulting in increased intestinal fluid and accelerated transit. In animal models, linaclotide has been shown to both accelerate GI transit and reduce intestinal pain. The linaclotide-induced reduction in visceral pain in animals is thought to be mediated by increased extracellular cGMP, which was shown to decrease the activity of pain-sensing nerves. | Guanylate Cyclase-C Agonist (Code: N0000185500) Guanylate Cyclase Activators (Code: N0000185499) Enzyme Activators (Code: D020536) Gastrointestinal Agents (Code: D005765) Guanylyl Cyclase C Agonists (Code: D000074268) | 2012-08-30 FDA | |
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| panobinostat | Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) Histone deacetylase 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q96DB2, gene: HDAC11, swissprot: HDA11_HUMAN) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) Histone deacetylase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKV0, gene: HDAC9, swissprot: HDAC9_HUMAN) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) Histone deacetylase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P56524, gene: HDAC4, swissprot: HDAC4_HUMAN) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) Histone deacetylase (Organism: Plasmodium falciparum, class: Enzyme, accessions: Q9XYC7, gene: HDAC1, swissprot: Q9XYC7_PLAFA) Histone deacetylase 5 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UQL6, gene: HDAC5, swissprot: HDAC5_HUMAN) Histone deacetylase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q8WUI4, gene: HDAC7, swissprot: HDAC7_HUMAN) | a hydroxamic acid analog histone deacetylase inhibitor from Novartis | Histone Deacetylase Inhibitor (Code: N0000175588) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Histone Deacetylase Inhibitors (Code: D056572) angiogenesis modulating agent (Code: CHEBI:50926) antineoplastic agent (Code: CHEBI:35610) | 2015-08-28 EMA 2015-02-23 FDA | 5EF8 |
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| phenylacetic acid | glutamine (Organism: None, class: Amino acid, accessions: None, gene: None, swissprot: None) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) | None | Ammonium Ion Binding Activity (Code: N0000175806) Nitrogen Binding Agent (Code: N0000175807) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) | 1987-12-23 FDA | 1FXH 1K5Q 1PNL 2INE 2ISF 2Y4N 3IXL 4YFB |
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| enzalutamide | Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) | Enzalutamide is an androgen receptor inhibitor that acts on different steps in the androgen receptor signaling pathway. Enzalutamide has been shown to competitively inhibit androgen binding to androgen receptors and inhibit androgen receptor nuclear translocation and interaction with DNA. A major metabolite, N'desmethyl enzalutamide, exhibited similar in vitro activity to enzalutamide. Enzalutamide decreased proliferation and induced cell death of prostate cancer cells in vitro, and decreased tumor volume in a mouse prostate cancer xenograft model. | Androgen Receptor Inhibitor (Code: N0000175560) Androgen Receptor Antagonists (Code: N0000000243) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 2C19 Inducers (Code: N0000185607) antineoplastic agent (Code: CHEBI:35610) androgen antagonist (Code: CHEBI:35497) | 2012-08-31 FDA | |
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| trabectedin | DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Nuclear receptor subfamily 1 group I member 2 (Organism: Mus musculus, class: Nuclear hormone receptor, accessions: O54915, gene: Nr1i2, swissprot: NR1I2_MOUSE) | a complex structure that includes isoquinolines joined by a cyclic ester; Guanine N2 alkylator with potent antiproliferative activity; a marine natural product from Ecteinascidia turbinata; ecteinascidin-729 is a metabolite; cells induced to tolerance for this have defective XP6 protein | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Noxae (Code: D009676) angiogenesis modulating agent (Code: CHEBI:50926) antineoplastic agent (Code: CHEBI:35610) anti-inflammatory agent (Code: CHEBI:67079) | 2015-09-04 PMDA 2015-10-23 FDA 2007-09-17 EMA | |
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| teriflunomide | Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q02127, gene: DHODH, swissprot: PYRD_HUMAN) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63707, gene: Dhodh, swissprot: PYRD_RAT) Dihydroorotate dehydrogenase (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q54A96, gene: dhod, swissprot: Q54A96_PLAFA) Dihydroorotate dehydrogenase (quinone), mitochondrial (Organism: Mus musculus, class: Enzyme, accessions: O35435, gene: Dhodh, swissprot: PYRD_MOUSE) | Teriflunomide, an immunomodulatory agent with anti-inflammatory properties, inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme involved in de novo pyrimidine synthesis. The exact mechanism by which teriflunomide exerts its therapeutic effect in multiple sclerosis is unknown but may involve a reduction in the number of activated lymphocytes in CNS. | Pyrimidine Synthesis Inhibitor (Code: N0000185502) Dihydroorotate Dehydrogenase Inhibitors (Code: N0000185501) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | 2013-08-26 EMA 2012-09-12 FDA | 1D3H 1TV5 |
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| Choline C-11 | High affinity choline transporter 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BGY9, gene: Slc5a7, swissprot: SC5A7_MOUSE) | None | Radioactive Diagnostic Agent (Code: N0000177914) Radiopharmaceutical Activity (Code: N0000000205) radioactive tracer (Code: CHEBI:35207) | 2012-09-12 FDA | |
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| oxabolone cipionate | None | |
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| eugenol | Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) | A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS. | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anti-Infective Agents (Code: D000890) Solvents (Code: D012997) | None FDA | 3S0E |
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| dipyrithione | None | None FDA | |
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| dimyristoylphosphatidylglycerol | None | None FDA | |
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| Padimate A | combined with PABA in Spectraban 15 lotion & with indomethacin in Spectraban 5.6 lotion | None FDA | |
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| oftasceine | None | Coloring Agents (Code: D004396) Fluorescent Dyes (Code: D005456) Indicators and Reagents (Code: D007202) Luminescent Agents (Code: D049408) fluorochrome (Code: CHEBI:51217) | None FDA | |
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| octyltriethoxysilane | None | None FDA | |
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| levmetamfetamine | Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) | sympathomimetic vasoconstrictor used as nasal decongestant | None FDA | |
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| dodecanoic acid | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) | None | None FDA | 1AYM 1AYN 1E7F 1EK4 1FK1 1FPN 1HZP 1M7W 1MA0 1QFF 1QFG 1S8G 1TJJ 1V9U 2AF9 2AG2 2AGC 2ALG 2B5S 2BYX 2BYZ 2BZ3 2EVD 2GFY 2GRX 2OVD 2QHD 2WYB 2WYD 2X5I 3ANP 3B18 3DPR 3FXI 3RBQ 3UEU 3UIL 3VQ2 4AED 4CU4 4DOO 4G8A 4IB6 4KJX 4KU5 4S0X 4TKB 4XRF 5C9J 5CWE 5FUS 5FVN 5HCN 5IJD 5NUA 5NUB 5UCA 5VNW 5W78 5W7C 5W7F |
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| glycolic acid | None | Dermatologic Agents (Code: D003879) Keratolytic Agents (Code: D007641) keratolytic drug (Code: CHEBI:50176) | None FDA | |
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| fluorometholone acetate | Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | None | 1986-02-11 FDA | |
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| dimyristoylphosphatidylcholine | A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. | Indicators and Reagents (Code: D007202) | 2002-05-31 FDA | 4C00 2XTV 3EMN 3UTV 3UTW 4C69 5KLB 5KLG 5KLS 5KMD 5KMF 5KMH |
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| chloramphenicol succinate | inactive precursor (PRODRUGS) of chloramphenicol; used for parenteral administration of chloramphenicol; RN given refers to (R-(R*,R*))-isomer | Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) | 1950-12-08 FDA | |
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| benzoic acid | Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) D-amino-acid oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P14920, gene: DAO, swissprot: OXDA_HUMAN) glycine (Organism: None, class: Amino acid, accessions: None, gene: None, swissprot: None) | A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. | Ammonium Ion Binding Activity (Code: N0000175806) Nitrogen Binding Agent (Code: N0000175807) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Food Additives (Code: D005503) Food Preservatives (Code: D005520) antimicrobial food preservative (Code: CHEBI:65256) drug allergen (Code: CHEBI:88188) | None FDA | |
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| brilliant green | None | Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Coloring Agents (Code: D004396) | None FDA | |
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| betiatide | None | None FDA | |
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| betamethasone phosphate | Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) | phosphate ester of betamethasone; RN given refers to the di-Na salt (11beta,16beta)-isomer; structure in Negwer,5th ed, 4975 | Adrenal Cortex Hormones (Code: D000305) Glucocorticoids (Code: D005938) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) | 1965-03-03 FDA | |
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| methylrosaniline | None | |
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| metizoline | Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) Nischarin (Organism: Rattus norvegicus, class: Unclassified, accessions: Q4G017, gene: Nisch, swissprot: NISCH_RAT) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) | None | |
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| nalfurafine | Nociceptin receptor (Organism: Homo sapiens, class: GPCR, accessions: P41146, gene: OPRL1, swissprot: OPRX_HUMAN) Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) Delta-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P32300, gene: Oprd1, swissprot: OPRD_MOUSE) Mu-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P97266, gene: OPRM1, swissprot: OPRM_CAVPO) Mu-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P42866, gene: Oprm1, swissprot: OPRM_MOUSE) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) Kappa-type opioid receptor (Organism: Mus musculus, class: GPCR, accessions: P33534, gene: Oprk1, swissprot: OPRK_MOUSE) | None | 2009-01-21 PMDA | |
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| naproxcinod | a nitric oxide-releasing NSAID derivative | non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) prodrug (Code: CHEBI:50266) | |
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| obidoxime | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | Cholinesterase reactivator occurring in two interchangeable isomeric forms, syn and anti. | Cholinergic Agents (Code: D018678) Cholinesterase Reactivators (Code: D002801) Enzyme Reactivators (Code: D004793) Neurotransmitter Agents (Code: D018377) | 2GYW |
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| omacetaxine mepesuccinate | alkaloid from Cephalotaxus harringtonia; RN given refers to (3(R))-isomer; FDA approved orphan drug status for Ceflatonin in the treatment of chronic myeloid leukemia due to being an inducer of apoptosis in myeloid cells and inhibitor of angiogenesis | Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Phytogenic (Code: D000972) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) antineoplastic agent (Code: CHEBI:35610) | 2012-10-26 FDA | 3G6E 4U4Q |
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| oritavancin | Staphylococcus aureus subsp. aureus (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) Streptococcus pneumoniae (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) Enterococcus faecalis ATCC 29212 (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) | None | Lipoglycopeptide Antibacterial (Code: N0000191281) Lipoglycopeptides (Code: N0000191280) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 2D6 Inducers (Code: N0000191267) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) antibacterial drug (Code: CHEBI:36047) | 2015-03-19 EMA 2014-08-06 FDA | |
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| ornipressin | A synthetic analog of vasopressin with ORNITHINE substitution at residue 8 of the cyclic nonapeptide. It is used as a local vasoconstrictor and hemostatic. | Cardiovascular Agents (Code: D002317) Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Vasoconstrictor Agents (Code: D014662) | |
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| paraoxon | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) Monoglyceride lipase (Organism: Mus musculus, class: Enzyme, accessions: O35678, gene: Mgll, swissprot: MGLL_MOUSE) Fatty-acid amide hydrolase 1 (Organism: Mus musculus, class: Enzyme, accessions: O08914, gene: Faah, swissprot: FAAH1_MOUSE) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) Cannabinoid receptor 1 (Organism: Mus musculus, class: GPCR, accessions: P47746, gene: Cnr1, swissprot: CNR1_MOUSE) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) | An organophosphate cholinesterase inhibitor that is used as a pesticide. | Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Insecticides (Code: D007306) Neurotransmitter Agents (Code: D018377) Pesticides (Code: D010575) | |
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| perampanel | Glutamate receptor ionotropic AMPA (Organism: Homo sapiens, class: Ion channel, accessions: P42261|P42262|P42263|P48058, gene: GRIA1|GRIA2|GRIA3|GRIA4, swissprot: GRIA1_HUMAN|GRIA2_HUMAN|GRIA3_HUMAN|GRIA4_HUMAN) | a non-competitive AMPA glutamate receptor antagonist indicated as adjunctive therapy for the treatment of seizures | Noncompetitive AMPA Glutamate Receptor Antagonist (Code: N0000186106) AMPA Receptor Antagonists (Code: N0000020016) anticonvulsant (Code: CHEBI:35623) | 2012-10-22 FDA | 5L1F |
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| pleconaril | Nuclear receptor subfamily 1 group I member 2 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: O75469, gene: NR1I2, swissprot: NR1I2_HUMAN) Protease (Organism: Human rhinovirus sp, class: Enzyme, accessions: Q4U254, gene: protease, swissprot: Q4U254_9ENTO) | None | Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) | 1C8M 1NA1 1NCQ 1NCR 1ND3 4WM7 |
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| phenothrin | None | Insecticides (Code: D007306) Pesticides (Code: D010575) pyrethroid ester insecticide (Code: CHEBI:39116) | |
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| phenylmercuric nitrate | None | |
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| picodralazine | None | |
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| remikiren | Renin (Organism: Homo sapiens, class: Enzyme, accessions: P00797, gene: REN, swissprot: RENI_HUMAN) | renin inhibitor under development for the treatment of hypertension | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) | 3D91 |
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| semustine | Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) | 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent. | Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) antineoplastic agent (Code: CHEBI:35610) | |
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| ritiometan | None | |
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| esatenolol | None | beta-adrenergic antagonist (Code: CHEBI:35530) | |
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| tofacitinib | Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) JAK2/TYK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674|P29597, gene: JAK2|TYK2, swissprot: JAK2_HUMAN|TYK2_HUMAN) JAK1/JAK2/TYK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674|P23458|P29597, gene: JAK1|JAK2|TYK2, swissprot: JAK1_HUMAN|JAK2_HUMAN|TYK2_HUMAN) JAK1/TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P23458|P29597, gene: JAK1|TYK2, swissprot: JAK1_HUMAN|TYK2_HUMAN) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) Serine/threonine-protein kinase PknB (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WI81, gene: pknB, swissprot: PKNB_MYCTU) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) Protein kinase C delta type (Organism: Homo sapiens, class: Kinase, accessions: Q05655, gene: PRKCD, swissprot: KPCD_HUMAN) Tyrosine-protein kinase JAK3 (Organism: Mus musculus, class: Kinase, accessions: Q62137, gene: Jak3, swissprot: JAK3_MOUSE) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) Tyrosine-protein kinase JAK2 (Organism: Mus musculus, class: Kinase, accessions: Q62120, gene: Jak2, swissprot: JAK2_MOUSE) Calcium/calmodulin-dependent protein kinase type II subunit delta (Organism: Homo sapiens, class: Kinase, accessions: Q13557, gene: CAMK2D, swissprot: KCC2D_HUMAN) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) JAK2/JAK1 (Organism: Homo sapiens, class: Kinase, accessions: O60674|P23458, gene: JAK1|JAK2, swissprot: JAK1_HUMAN|JAK2_HUMAN) JAK3/JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458|P52333, gene: JAK1|JAK3, swissprot: JAK1_HUMAN|JAK3_HUMAN) | Tofacitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function. Within the signaling pathway, JAKs phosphorylate and activate Signal Transducers and Activators of Transcription (STATs) which modulate intracellular activity including gene expression. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. | Janus Kinase Inhibitor (Code: N0000190858) Janus Kinase Inhibitors (Code: N0000190857) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antirheumatic drug (Code: CHEBI:35842) | 2012-11-06 FDA | 3EYG 3FUP 3LXK 3LXN 4OTI |
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| cabozantinib | Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Macrophage-stimulating protein receptor (Organism: Homo sapiens, class: Kinase, accessions: Q04912, gene: MST1R, swissprot: RON_HUMAN) | Cabozantinib inhibits the tyrosine kinase activity of MET, VEGFR-1, -2 and -3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, FLT-3, and TIE-2. These receptor tyrosine kinases are involved in both normal cellular function and pathologic processes such as oncogenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor microenvironment. | Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) | 2014-03-21 EMA 2012-11-29 FDA | |
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| ponatinib | Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Gallus gallus, class: Kinase, accessions: P00523, gene: SRC, swissprot: SRC_CHICK) Breakpoint cluster region protein (Organism: Homo sapiens, class: Kinase, accessions: P11274, gene: BCR, swissprot: BCR_HUMAN) Bcr/Abl fusion protein (Organism: Homo sapiens, class: Kinase, accessions: P00519|P11274, gene: ABL1|BCR, swissprot: ABL1_HUMAN|BCR_HUMAN) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) Cyclin-dependent kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P49336, gene: CDK8, swissprot: CDK8_HUMAN) Cyclin-dependent kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q9BWU1, gene: CDK19, swissprot: CDK19_HUMAN) | a pan-Bcr-Abl protein kinase Inhibitor | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2012-12-14 FDA | 3IK3 3OXZ 3ZOS 4C8B 4QRC 4TYJ 4U0I 4UXQ 4V01 4V04 |
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| teduglutide | Glucagon-like peptide 2 receptor (Organism: Homo sapiens, class: GPCR, accessions: O95838, gene: GLP2R, swissprot: GLP2R_HUMAN) | an analogue of human glucagon-like peptide-2 (GLP-2) preserves mucosal integrity by promoting repair and normal growth of the intestine through an increase of villus height and crypt depth | Gastrointestinal Agents (Code: D005765) GLP-2 Analog (Code: N0000190992) Glucagon-like Peptide-2 (GLP-2) Agonists (Code: N0000190990) Glucagon-Like Peptide 2 (Code: N0000175140) Analogs/Derivatives (Code: N0000175452) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) protective agent (Code: CHEBI:50267) | 2012-08-30 EMA 2012-12-21 FDA | |
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| daunorubicinol | Multidrug resistance-associated protein 6 (Organism: Homo sapiens, class: Transporter, accessions: O95255, gene: ABCC6, swissprot: MRP6_HUMAN) ATP-binding cassette sub-family G member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UNQ0, gene: ABCG2, swissprot: ABCG2_HUMAN) Multidrug resistance-associated protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P33527, gene: ABCC1, swissprot: MRP1_HUMAN) DNA topoisomerase 2-alpha (Organism: Homo sapiens, class: Enzyme, accessions: P11388, gene: TOP2A, swissprot: TOP2A_HUMAN) Multidrug resistance protein 1 (Organism: Homo sapiens, class: Transporter, accessions: P08183, gene: ABCB1, swissprot: MDR1_HUMAN) | main metabolite of daunomycin | 1964-01-01 YEAR INTRODUCED | |
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| lomitapide | Microsomal triglyceride transfer protein large subunit (Organism: Homo sapiens, class: Cytosolic other, accessions: P55157, gene: MTTP, swissprot: MTP_HUMAN) | an anticholesteremic agent and microsomal triglycide transfer protein inhibitor | Microsomal Triglyceride Transfer Protein Inhibitor (Code: N0000186779) Microsomal Triglyceride Transfer Protein Inhibitors (Code: N0000186778) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) anticholesteremic drug (Code: CHEBI:35821) | 2012-12-21 FDA | |
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| succinimide | None | |
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| tacalcitol | Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) | None | |
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| tenidap | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) Cytochrome P450 1A2 (Organism: Homo sapiens, class: Enzyme, accessions: P05177, gene: CYP1A2, swissprot: CP1A2_HUMAN) Inward rectifier potassium channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: P48050, gene: KCNJ4, swissprot: KCNJ4_HUMAN) Prostaglandin G/H synthase 1 (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: O97554, gene: PTGS1, swissprot: PGH1_RABIT) Prostaglandin G/H synthase 2 (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: O02768, gene: PTGS2, swissprot: PGH2_RABIT) Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) Cyclooxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P35355|Q63921, gene: Ptgs1|Ptgs2, swissprot: PGH1_RAT|PGH2_RAT) | None | Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) | |
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| trimethyldiphenylpropylamine | None | |
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| tetragalacturonic acid hydroxymethylester | None | |
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| tetramethrin | None | Insecticides (Code: D007306) Pesticides (Code: D010575) pyrethroid ester insecticide (Code: CHEBI:39116) | |
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| thiocolchicoside | GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA A receptor alpha-1/beta-1/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18505|P18507, gene: GABRA1|GABRB1|GABRG2, swissprot: GBRA1_HUMAN|GBRB1_HUMAN|GBRG2_HUMAN) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) | used in combination with glafenine and meprobamate to tranquilize patients undergoing hysterosalpingography; structure | |
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| thioctic acid | Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) SUMO-activating enzyme (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBE0|Q9UBT2, gene: SAE1|UBA2, swissprot: SAE1_HUMAN|SAE2_HUMAN) Bifunctional protein GlmU (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WMN3, gene: glmU, swissprot: GLMU_MYCTU) | An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS. | Antioxidants (Code: D000975) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Protective Agents (Code: D020011) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) | None FDA | 1DP2 1HPC 1X2H 2ART 2C8M 2IQD 5IBY 5IJ6 5T8U |
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| ticlatone | None | |
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| trimegestone | ligand for progesterone receptor | |
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| bedaquiline | ATP synthase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPS1|P9WPU5|P9WPU7|P9WPU9|P9WPV1|P9WPV3|P9WPV5|P9WPV7, gene: atpA|atpB|atpC|atpD|atpE|atpF|atpFH|atpG, swissprot: ATP6_MYCTU|ATPA_MYCTU|ATPB_MYCTU|ATPE_MYCTU|ATPFD_MYCTU|ATPF_MYCTU|ATPG_MYCTU|ATPL_MYCTU) ATP synthase subunit c (Organism: Mycobacterium smegmatis, class: Unclassified, accessions: Q5TIX5, gene: atpE, swissprot: Q5TIX5_MYCSM) | Bedaquiline is a diarylquinoline antimycobacterial drug that inhibits mycobacterial ATP (adenosine 5'-triphosphate) synthase, by binding to subunit c of the enzyme that is essential for the generation of energy in M. tuberculosis. | Diarylquinoline Antimycobacterial (Code: N0000186775) Diarylquinolines (Code: N0000186774) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) antitubercular agent (Code: CHEBI:33231) | 2012-12-28 FDA | 4V1F |
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| etallobarbital | None | |
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| biphenylol | None | 5BRT |
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| dimethylaminopropionylphenothiazine | None | |
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| dimethylcarbate | None | |
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| dimethylphthalate | used as plasticizer in computer mouse; structure | Fixatives (Code: D005404) Insect Repellents (Code: D007302) Pesticides (Code: D010575) Protective Agents (Code: D020011) | |
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| dipiperonylaminoethanol | None | |
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| ethyl hydroxybenzoate | Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) | None | Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) | 3VPK |
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| etohexadiol | insect repellent, moderately irritating to eyes, mucous membranes, but not to skin; RN given refers to cpd without isomeric designation; structure | |
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| fluoromethylcholine (18F) | None | |
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| seractide | Adrenocorticotropic hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q01718, gene: MC2R, swissprot: ACTHR_HUMAN) | None | 1978-02-21 FDA | |
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| vilanterol | Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) | Vilanterol is a long-acting beta2-adrenergic agonist. The clinical relevance of this in vitro finding is unknown. Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the heart, there are also beta2-receptors in the human heart comprising 10% to 50% of the total beta-adrenergic receptors. The precise function of these receptors has not been established, but they raise the possibility that even highly selective beta2-agonists may have cardiac effects. The pharmacologic effects of beta2-adrenergic agonist drugs, including vilanterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. | Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) | 2013-05-10 FDA | |
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| ridaforolimus | Serine/threonine-protein kinase mTOR (Organism: Homo sapiens, class: Kinase, accessions: P42345, gene: MTOR, swissprot: MTOR_HUMAN) | an mTOR inhibitor for the treatment of cancer | antineoplastic agent (Code: CHEBI:35610) | |
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| dabrafenib | Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) TGF-beta receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: P36897, gene: TGFBR1, swissprot: TGFR1_HUMAN) RAF proto-oncogene serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P04049, gene: RAF1, swissprot: RAF1_HUMAN) Serine/threonine-protein kinase A-Raf (Organism: Homo sapiens, class: Kinase, accessions: P10398, gene: ARAF, swissprot: ARAF_HUMAN) | an antineoplastic agent that inhibits BRAF kinase; InChIKey: BFSMGDJOXZAERB-UHFFFAOYSA-N | Kinase Inhibitor (Code: N0000175605) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 2B6 Inducers (Code: N0000187064) Cytochrome P450 2C8 Inducers (Code: N0000187063) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 2C19 Inducers (Code: N0000185607) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Organic Anion Transporter 1 Inhibitors (Code: N0000190110) Organic Anion Transporter 3 Inhibitors (Code: N0000190111) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2013-08-26 EMA 2013-05-29 FDA | 4XV2 5CSW 5HIE |
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| trametinib | Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) | a reversible inhibitor of mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 activation and of MEK1 and MEK2 kinase activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation | Kinase Inhibitor (Code: N0000175605) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) antineoplastic agent (Code: CHEBI:35610) | 2013-05-29 FDA | |
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| sequifenadine | None | |
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| corticotropin | Melanocyte-stimulating hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q01726, gene: MC1R, swissprot: MSHR_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Adrenocorticotropic hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q01718, gene: MC2R, swissprot: ACTHR_HUMAN) | A hormone made in the pituitary gland. ACTH acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More ACTH is made during times of stress. | Adrenocorticotropic Hormone (Code: N0000006478) diagnostic agent (Code: CHEBI:33295) | 1950-07-03 FDA | |
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| afamelanotide | Melanocyte-stimulating hormone receptor (Organism: Homo sapiens, class: GPCR, accessions: Q01726, gene: MC1R, swissprot: MSHR_HUMAN) Melanocortin receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P32245, gene: MC4R, swissprot: MC4R_HUMAN) Melanocortin receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P41968, gene: MC3R, swissprot: MC3R_HUMAN) Melanocortin receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P33032, gene: MC5R, swissprot: MC5R_HUMAN) | observations suggest that afamelanotide has beneficial effects in patients with erythropoietic protoporphyria, induces epidermal melanin formation | Dermatologic Agents (Code: D003879) | 2014-12-12 EMA | |
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| vorapaxar | Proteinase-activated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P25116, gene: F2R, swissprot: PAR1_HUMAN) | has antiplatelet activity | Protease-activated Receptor-1 Antagonist (Code: N0000190996) Protease-activated Receptor-1 Antagonists (Code: N0000190995) Hematologic Agents (Code: D006401) Platelet Aggregation Inhibitors (Code: D010975) platelet aggregation inhibitor (Code: CHEBI:50427) cardiovascular drug (Code: CHEBI:35554) | 2014-05-08 FDA 2014-11-20 EMA | 3VW7 |
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| albiglutide | Glucagon-like peptide 1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P43220, gene: GLP1R, swissprot: GLP1R_HUMAN) Glucagon-like peptide 1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P32301, gene: Glp1r, swissprot: GLP1R_RAT) | A long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, with antihyperglycemic activity. Albiglutide is composed of a GLP-1 (7-36) dimer fused to recombinant human albumin. Upon subcutaneous administration, this agent has a half-life of 4-7 days and resists degradation by dipeptidyl peptidase-4 (DPP-4). | GLP-1 Receptor Agonist (Code: N0000178480) Glucagon-like Peptide-1 (GLP-1) Agonists (Code: N0000020058) | 2014-04-15 FDA | |
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| glycobiarsol | None | |
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| levomilnacipran | Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) | a selective serotonin and norepinephrine reuptake inhibitor (SNRI), mechanism of the antidepressant action of levomilnacipran is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system | Norepinephrine Uptake Inhibitors (Code: N0000000102) Serotonin and Norepinephrine Reuptake Inhibitor (Code: N0000175749) Serotonin Uptake Inhibitors (Code: N0000000109) | 2013-07-25 FDA | |
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| cridanimod | Trypsin (Organism: Sus scrofa, class: Unclassified, accessions: P00761, gene: None, swissprot: TRYP_PIG) | A small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy. | 4JC5 |
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| sodium thiosalicylate | a degradation product of thimerosal; RN given refers to parent cpd | 3LK1 4E4A |
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| estrone sulphate | Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) Estrogen receptor beta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q92731, gene: ESR2, swissprot: ESR2_HUMAN) Steryl-sulfatase (Organism: Homo sapiens, class: Enzyme, accessions: P08842, gene: STS, swissprot: STS_HUMAN) Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) | used therapeutically in menopausal patients | Contraceptive Agents (Code: D003270) Reproductive Control Agents (Code: D012102) | 1977-05-19 FDA | |
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| corticorelin | Corticotropin-releasing factor receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P34998, gene: CRHR1, swissprot: CRFR1_HUMAN) Corticotropin-releasing factor receptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P47866, gene: Crhr2, swissprot: CRFR2_RAT) Corticotropin-releasing factor receptor 2 (Organism: Mus musculus, class: Unclassified, accessions: Q60748, gene: Crhr2, swissprot: CRFR2_MOUSE) | None | |
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| mebicar | None | Analgesics (Code: D000700) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) | |
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| nicotinyl methylamide | None | |
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| phenibut | GABA-B receptor (Organism: Homo sapiens, class: GPCR, accessions: O75899|Q9UBS5, gene: GABBR1|GABBR2, swissprot: GABR1_HUMAN|GABR2_HUMAN) | phenyl deriv of GABA; RN given refers to cpd without isomeric designation; structure | |
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| tofogliflozin | Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) | inhibits sodium-glucose cotransporter 2 | 2014-03-24 PMDA | |
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| tipiracil | Thymidine phosphorylase (Organism: Homo sapiens, class: Enzyme, accessions: P19971, gene: TYMP, swissprot: TYPH_HUMAN) Thymidine phosphorylase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P07650, gene: deoA, swissprot: TYPH_ECOLI) | tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase | Thymidine Phosphorylase Inhibitor (Code: N0000191870) Thymidine Phosphorylase Inhibitors (Code: N0000191869) antineoplastic agent (Code: CHEBI:35610) | 2015-09-22 FDA 2014-03-24 PMDA | 1UOU |
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| iguratimod | a methanesulfonanilide disease-modifying antirheumatic drug that has been developed exclusively in Japan and China | 2012-06-29 PMDA | |
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| teneligliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Dipeptidyl peptidase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q6V1X1, gene: DPP8, swissprot: DPP8_HUMAN) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) Dipeptidyl peptidase 4 (Organism: Rattus norvegicus, class: Enzyme, accessions: P14740, gene: Dpp4, swissprot: DPP4_RAT) | A long-acting, orally bioavailable, pyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Teneligliptin may also reduce plasma triglyceride levels through a sustained increase in GLP-1 levels. | 2012-06-29 PMDA | 3VJK |
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| anagliptin | Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) Dipeptidyl peptidase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q6V1X1, gene: DPP8, swissprot: DPP8_HUMAN) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) Prolyl endopeptidase FAP (Organism: Homo sapiens, class: Enzyme, accessions: Q12884, gene: FAP, swissprot: SEPR_HUMAN) | anagliptin hydrochloride salt is the active compound | Dipeptidyl-Peptidase IV Inhibitors (Code: D054873) Enzyme Inhibitors (Code: D004791) Hypoglycemic Agents (Code: D007004) Protease Inhibitors (Code: D011480) | 2012-09-28 PMDA | 3WQH |
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| edoxaban | Coagulation factor X (Organism: Homo sapiens, class: Enzyme, accessions: P00742, gene: F10, swissprot: FA10_HUMAN) | An orally active inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Edoxaban is administered as edoxaban tosylate. This agent has an elimination half-life of 9-11 hours and undergoes renal excretion. | Factor Xa Inhibitor (Code: N0000175637) Anticoagulants (Code: D000925) Antithrombins (Code: D000991) Enzyme Inhibitors (Code: D004791) Factor Xa Inhibitors (Code: D065427) Hematologic Agents (Code: D006401) Protease Inhibitors (Code: D011480) Serine Proteinase Inhibitors (Code: D015842) anticoagulant (Code: CHEBI:50249) platelet aggregation inhibitor (Code: CHEBI:50427) | 2015-06-19 EMA 2015-01-08 FDA 2011-04-22 PMDA | |
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| fimasartan | Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) | an angiotensin II receptor antagonist | 2010-09-01 Korean Food and Drug Administration (KFDA) | |
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| olaparib | Poly [ADP-ribose] polymerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P09874, gene: PARP1, swissprot: PARP1_HUMAN) Poly [ADP-ribose] polymerase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UGN5, gene: PARP2, swissprot: PARP2_HUMAN) Tankyrase-1 (Organism: Homo sapiens, class: Enzyme, accessions: O95271, gene: TNKS, swissprot: TNKS1_HUMAN) Poly [ADP-ribose] polymerase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6F1, gene: PARP3, swissprot: PARP3_HUMAN) | Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. PARP enzymes are involved in normal cellular homeostasis, such as DNA transcription, cell cycle regulation, and DNA repair. Olaparib has been shown to inhibit growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer both as monotherapy or following platinum-based chemotherapy. Increased cytotoxicity and anti-tumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complex, resulting in disruption of cellular homeostasis and cell death. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Poly(ADP-Ribose) Polymerase Inhibitor (Code: N0000191623) Poly(ADP-ribose) Polymerase Inhibitors (Code: D000067856) antineoplastic agent (Code: CHEBI:35610) | 2014-12-19 FDA 2014-10-23 EMA | 3U9Y 4TKG 4TVJ 5DS3 |
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| paritaprevir | inhibits HCV NS3 protease | HCV NS3/4A Protease Inhibitors (Code: N0000182638) Hepatitis C Virus NS3/4A Protease Inhibitor (Code: N0000182639) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) UGT1A1 Inhibitors (Code: N0000191272) P-Glycoprotein Inhibitors (Code: N0000185503) antiviral drug (Code: CHEBI:36044) | 2014-12-19 FDA 2014-11-20 EMA | |
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| dasabuvir | Dasabuvir is a non-nucleoside inhibitor of the HCV RNA-dependent RNA polymerase encoded by the NS5B gene, which is essential for replication of the viral genome. In a biochemical assay, dasabuvir inhibited a panel of genotype 1a and 1b NS5B polymerases. Based on drug resistance mapping studies of HCV genotypes 1a and 1b, dasabuvir targets the palm domain of the NS5B polymerase, and is therefore referred to as a non-nucleoside NS5B-palm polymerase inhibitor. | Hepatitis C Virus Non-Nucleoside NS5B Palm Polymerase Inhibitor (Code: N0000191257) RNA Replicase Inhibitors (Code: N0000191258) UGT1A1 Inhibitors (Code: N0000191272) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) antiviral drug (Code: CHEBI:36044) | 2014-12-19 FDA 2014-11-20 EMA | |
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| alectinib | Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) | Alectinib is a tyrosine kinase inhibitor that targets ALK and RET. In nonclinical studies, alectinib inhibited ALK phosphorylation and ALK-mediated activation of the downstream signaling proteins STAT3 and AKT, and decreased tumor cell viability in multiple cell lines harboring ALK fusions, amplifications, or activating mutations. The major active metabolite of alectinib, M4, showed similar in vitro potency and activity. | Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) antineoplastic agent (Code: CHEBI:35610) | 2017-02-16 EMA 2015-12-11 FDA 2014-07-04 PMDA | 3AOX 5XV7 |
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| ripasudil | Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) | Rho-associated kinase inhibitor for the treatment of glaucoma and ocular hypertension | 2014-09-26 PMDA | |
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| vaniprevir | Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) Genome polyprotein (Organism: Hepatitis C virus genotype 2a (isolate JFH-1), class: Polyprotein, accessions: Q99IB8, gene: None, swissprot: POLG_HCVJF) Cathepsin S (Organism: Homo sapiens, class: Enzyme, accessions: P25774, gene: CTSS, swissprot: CATS_HUMAN) Nonstructural protein NS3-4A (Organism: Hepatitis C virus, class: Unclassified, accessions: A0A0K1CY61, gene: None, swissprot: A0A0K1CY61_9HEPC) | inhibits hepatitis C virus NS3/4a protease | 2014-09-26 PMDA | |
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| vonoprazan | Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) | a potassium-competitive proton pump blocker for the treatment of acid-related disorders | 2014-12-26 PMDA | 5YLU |
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| mirodenafil | cGMP-specific 3',5'-cyclic phosphodiesterase (Organism: Homo sapiens, class: Enzyme, accessions: O76074, gene: PDE5A, swissprot: PDE5A_HUMAN) | phosphodiesterase type V inhibitor | Enzyme Inhibitors (Code: D004791) Phosphodiesterase 5 Inhibitors (Code: D058986) Phosphodiesterase Inhibitors (Code: D010726) | 2007-07-18 Korean Food and Drug Administration (KFDA) | |
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| cariprazine | D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) | The efficacy of cariprazine could be mediated through a combination of partial agonist activity at central dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. | Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Atypical Antipsychotic (Code: N0000175430) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) dopamine agonist (Code: CHEBI:51065) second generation antipsychotic (Code: CHEBI:65191) serotonergic antagonist (Code: CHEBI:48279) | 2015-09-17 FDA | |
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| ozenoxacin | Ozenoxacin is a quinolone antimicrobial drug. The mechanism of action involves the inhibition of bacterial DNA replication enzymes, DNA gyrase A and topoisomerase IV. Ozenoxacin has been shown to be bactericidal against S. aureus and S. pyogenes organisms. Ozenoxacin is used as topical treatment for impetigo and other infectious dermatological conditions. | 2017-12-11 FDA 2015-09-28 PMDA | |
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| lusutrombopag | Thrombopoietin receptor (Organism: Homo sapiens, class: Membrane receptor, accessions: P40238, gene: MPL, swissprot: TPOR_HUMAN) | a thrombopoietin receptor agonist | 2015-09-28 PMDA | |
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| esflurbiprofen | Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) Prostaglandin G/H synthase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63921, gene: Ptgs1, swissprot: PGH1_RAT) | None | 2015-09-28 PMDA | 1CQE 1DVT 1EQH 1R9O 2AYL 3N8W 3N8Z 3PGH 4FOR 4JTQ 5JVZ |
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| osimertinib | Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) | Osimertinib is a kinase inhibitor of the epidermal growth factor receptor (EGFR), which binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion) at approximately 9-fold lower concentrations than wild-type. In cultured cells and animal tumor implantation models, osimertinib exhibited anti-tumor activity against NSCLC lines harboring EGFR-mutations (T790M/L858R, L858R, T790M/exon 19 deletion, and exon 19 deletion) and, to a lesser extent, wild-type EGFR amplifications. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 3A4 Inducers (Code: N0000185506) Cytochrome P450 1A2 Inducers (Code: N0000191266) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) Protein Kinase Inhibitors (Code: D047428) | 2016-02-02 EMA 2015-11-13 FDA | 4ZAU |
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| lesinurad | Solute carrier family 22 member 12 (Organism: Homo sapiens, class: Transporter, accessions: Q96S37, gene: SLC22A12, swissprot: S22AC_HUMAN) Solute carrier family 22 member 11 (Organism: Homo sapiens, class: Transporter, accessions: Q9NSA0, gene: SLC22A11, swissprot: S22AB_HUMAN) | Lesinurad reduces serum uric acid levels by inhibiting the function of transporter proteins involved in uric acid reabsorption in the kidney. Lesinurad inhibited the function of two apical transporters responsible for uric acid reabsorption, uric acid transporter 1 (URAT1) and organic anion transporter 4 (OAT4), with IC50 values of 7.3 and 3.7 muM, respectively. URAT1 is responsible for the majority of the reabsorption of filtered uric acid from the renal tubular lumen. OAT4 is a uric acid transporter associated with diuretic-induced hyperuricemia. | Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074) Urate Transporter 1 Inhibitor (Code: N0000192341) Urate Transporter 1 Inhibitors (Code: N0000192340) Cytochrome P450 3A Inducers (Code: N0000190118) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) uricosuric drug (Code: CHEBI:35841) | 2016-02-18 EMA 2015-12-22 FDA | |
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| selexipag | Prostacyclin receptor (Organism: Homo sapiens, class: GPCR, accessions: P43119, gene: PTGIR, swissprot: PI2R_HUMAN) Prostacyclin receptor (Organism: Rattus norvegicus, class: Unclassified, accessions: P43253, gene: Ptgir, swissprot: PI2R_RAT) | an oral prostacyclin receptor (IP receptor) agonist that is structurally distinct from prostacyclin, indicated for the treatment of pulmonary arterial hypertension, selexipag is hydrolyzed by carboxylesterase 1 to yield its active metabolite, which is approximately 37-fold as potent as selexipag, selexipag and the active metabolite are selective for the IP receptor versus other prostanoid receptors (EP1-4, DP, FP and TP) | Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Prostacyclin Receptor Agonist (Code: N0000192339) Prostacyclin Receptor Agonists (Code: N0000020068) orphan drug (Code: CHEBI:71031) platelet aggregation inhibitor (Code: CHEBI:50427) vasodilator agent (Code: CHEBI:35620) prodrug (Code: CHEBI:50266) | 2015-12-21 FDA | |
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| lobeglitazone | Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) | putative antidiabetic agent for type 2 diabetes | 2013-07-04 Korean Food and Drug Administration (KFDA) | 5Y2T |
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| nemonoxacin | Streptococcus pneumoniae (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) Staphylococcus aureus subsp. aureus (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) | has antibacterial activity | |
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| arterolane | a trioxolane with antimalarial activity | 2012-03-09 CDSCO (INDIA) | |
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| hydracarbazine | A hydrazinopyridazine-based diuretic with antihypertensive activity. Hydracarbazine is no longer marketed. | |
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| cytisine | None | nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) | 4BQT 5SYO |
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| valbenazine | Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) Synaptic vesicular amine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q01827, gene: Slc18a2, swissprot: VMAT2_RAT) | The mechanism of action of valbenazine in the treatment of tardive dyskinesia is unknown, but is thought to be mediated through the reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release. | Vesicular Monoamine Transporter 2 Inhibitor (Code: N0000190856) Vesicular Monoamine Transporter 2 Inhibitors (Code: N0000190855) | 2017-04-11 FDA | |
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| plecanatide | Heat-stable enterotoxin receptor (Organism: Homo sapiens, class: Enzyme, accessions: P25092, gene: GUCY2C, swissprot: GUC2C_HUMAN) | Plecanatide is structurally related to human uroguanylin, and similar to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP). Elevation of intracellular cGMP stimulates secretion of chloride and bicarbonate into the intestinal lumen, mainly through activation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, resulting in increased intestinal fluid and accelerated transit. | Enzyme Activators (Code: D020536) Gastrointestinal Agents (Code: D005765) Guanylyl Cyclase C Agonists (Code: D000074268) Guanylate Cyclase-C Agonist (Code: N0000185500) Guanylate Cyclase Activators (Code: N0000185499) | 2017-01-19 FDA | |
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| niraparib | Poly [ADP-ribose] polymerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P09874, gene: PARP1, swissprot: PARP1_HUMAN) Poly [ADP-ribose] polymerase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UGN5, gene: PARP2, swissprot: PARP2_HUMAN) | Niraparib is an inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, PARP-1 and PARP-2, which play a role in DNA repair. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death. Increased niraparib-induced cytotoxicity was observed in tumor cell lines with or without deficiencies in BRCA1/2. Niraparib decreased tumor growth in mouse xenograft models of human cancer cell lines with deficiencies in BRCA1/2 and in human patient-derived xenograft tumor models with homologous recombination deficiency that had either mutated or wild type BRCA1/2. | Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Poly(ADP-Ribose) Polymerase Inhibitor (Code: N0000191623) Poly(ADP-ribose) Polymerase Inhibitors (Code: D000067856) | 2017-03-27 FDA | 4R6E |
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| abaloparatide | Parathyroid hormone/parathyroid hormone-related peptide receptor (Organism: Homo sapiens, class: GPCR, accessions: Q03431, gene: PTH1R, swissprot: PTH1R_HUMAN) | Abaloparatide is a PTHrP(1-34) analog which acts as an agonist at the PTH1 receptor (PTH1R). This results in activation of the cAMP signaling pathway in target cells. In rats and monkeys, abaloparatide had an anabolic effect on bone, demonstrated by increases in BMD and bone mineral content (BMC) that correlated with increases in bone strength at vertebral and/or nonvertebral sites. | Bone Density Conservation Agents (Code: D050071) | 2017-04-28 FDA | |
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| brigatinib | ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) | Brigatinib is a tyrosine kinase inhibitor with in vitro activity at clinically achievable concentrations against multiple kinases including ALK, ROS1, insulin-like growth factor-1 receptor (IGF-1R), and FLT-3 as well as EGFR deletion and point mutations. Brigatinib inhibited autophosphorylation of ALK and ALK-mediated phosphorylation of the downstream signaling proteins STAT3, AKT, ERK1/2, and S6 in in vitro and in vivo assays. Brigatinib also inhibited the in vitro proliferation of cell lines expressing EML4-ALK and NPM-ALK fusion proteins and demonstrated dose-dependent inhibition of EML4-ALK-positive NSCLC xenograft growth in mice. At clinically achievable concentrations (<= 500 nM), brigatinib inhibited the in vitro viability of cells expressing EML4-ALK and 17 mutant forms associated with resistance to ALK inhibitors including crizotinib, as well as EGFR-Del (E746-A750), ROS1-L2026M, FLT3-F691L, and FLT3-D835Y. Brigatinib exhibited in vivo anti-tumor activity against 4 mutant forms of EML4-ALK, including G1202R and L1196M mutants identified in NSCLC tumors in patients who have progressed on crizotinib. Brigatinib also reduced tumor burden and prolonged survival in mice implanted intracranially with an ALK-driven tumor cell line. | Kinase Inhibitor (Code: N0000175605) Tyrosine Kinase Inhibitors (Code: N0000020001) Cytochrome P450 3A Inducers (Code: N0000190118) | 2017-04-28 FDA | 5J7H |
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| voxilaprevir | Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) Genome polyprotein (Organism: Hepatitis C virus genotype 3a (isolate k3a) (HCV), class: Polyprotein, accessions: Q81495, gene: None, swissprot: POLG_HCVK3) | Voxilaprevir is a noncovalent, reversible inhibitor of the NS3/4A protease, which is necessary for the proteolytic cleavage of the HCV encoded polyprotein (into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins) and is essential for viral replication. In a biochemical inhibition assay, voxilaprevir inhibited the proteolytic activity of recombinant NS3/4A enzymes from clinical isolates of HCV genotypes 1b and 3a with Ki values of 38 and 66 pM, respectively. | 2017-07-18 FDA | |
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| glecaprevir | Glecaprevir is an inhibitor of the HCV NS3/4A protease, which is necessary for the proteolytic cleavage of the HCV encoded polyprotein (into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins) and is essential for viral replication. In a biochemical assay, glecaprevir inhibited the proteolytic activity of recombinant NS3/4A enzymes from clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a with IC50 values ranging from 3.5 to 11.3 nM. | 2017-08-03 FDA | |
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| butylphthalide | Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) | 3-N-Butylphthalide (NBP) is a compound found in Chinese celery seed extracts that can improve cognitive functions and may decrease Amyloid-beta levels in Alzheimer's disease. NBP has antioxidant activities and may protect against oxidative/nitrosative stress, mitochondrial impairment and apoptosis. | 2002-09-30 China Food and Drug Administration (CFDA) | |
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| halothane | Glycine receptor (alpha-1/beta) (Organism: Homo sapiens, class: Ion channel, accessions: P23415|P48167, gene: GLRA1|GLRB, swissprot: GLRA1_HUMAN|GLRB_HUMAN) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178) | inhalation anaesthetic (Code: CHEBI:38870) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) | 1958-03-12 FDA | |
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| abemaciclib | Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) Cyclin-dependent kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q00534, gene: CDK6, swissprot: CDK6_HUMAN) | Abemaciclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). These kinases are activated upon binding to D-cyclins. In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4/6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation. In vitro, continuous exposure to abemaciclib inhibited Rb phosphorylation and blocked progression from G1 into S phase of the cell cycle, resulting in senescence and apoptosis. In breast cancer xenograft models, abemaciclib dosed daily without interruption as a single agent or in combination with antiestrogens resulted in reduction of tumor size. | 2017-09-28 FDA | 5L2S |
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| semaglutide | Glucagon-like peptide 1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P43220, gene: GLP1R, swissprot: GLP1R_HUMAN) | Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1. Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor, the target for native GLP-1. GLP-1 is a physiological hormone that has multiple actions on glucose, mediated by the GLP-1 receptors. The principal mechanism of protraction resulting in the long half-life of semaglutide is albumin binding, which results in decreased renal clearance and protection from metabolic degradation. Furthermore, semaglutide is stabilized against degradation by the DPP-4 enzyme. Semaglutide reduces blood glucose through a mechanism where it stimulates insulin secretion and lowers glucagon secretion, both in a glucose-dependent manner. Thus, when blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited. The mechanism of blood glucose lowering also involves a minor delay in gastric emptying in the early postprandial phase. | 2017-12-05 FDA | |
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| guaiazulen | None | |
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| hexamethonium | Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) Acetylcholine receptor (Organism: Torpedo californica, class: Ion channel, accessions: P02710|P02712|P02714|P02718, gene: CHRNA1|CHRNB1|CHRNG|chrnd, swissprot: ACHA_TORCA|ACHB_TORCA|ACHD_TORCA|ACHG_TORCA) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Homo sapiens, class: Ion channel, accessions: P43681, gene: CHRNA4, swissprot: ACHA4_HUMAN) Neuronal acetylcholine receptor subunit alpha-6 (Organism: Homo sapiens, class: Ion channel, accessions: Q15825, gene: CHRNA6, swissprot: ACHA6_HUMAN) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) | A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool. | Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) | |
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| hexafluronium | Butyrylcholinesterase (Organism: Equus caballus, class: Enzyme, accessions: Q9N1N9, gene: BCHE, swissprot: Q9N1N9_HORSE) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) | curarimimetic agent for use with succinylcholine; muscle relaxant; structure; RN given refers to parent cpd | None FDA | |
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| betacarotene | Core protein (Organism: Hepatitis C virus, class: Unclassified, accessions: Q2Q167, gene: None, swissprot: Q2Q167_9HEPC) | A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). | Growth Substances (Code: D006133) Micronutrients (Code: D018977) Provitamins (Code: D000072664) Vitamins (Code: D014815) | None FDA | |
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| chloroform | A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity. | Solvents (Code: D012997) refrigerant (Code: CHEBI:78433) central nervous system drug (Code: CHEBI:35470) inhalation anaesthetic (Code: CHEBI:38870) | |
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| iodoform | None | |
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| lycopene | None | Anticarcinogenic Agents (Code: D016588) Antineoplastic Agents (Code: D000970) Antioxidants (Code: D000975) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) | None FDA | 1LGH |
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| perflenapent | a phase shift contrast agent that uses dodecafluoropentane as the enhancing gas | Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) radioopaque medium (Code: CHEBI:37338) | |